MCID: ADN005
MIFTS: 26

Adenosquamous Gallbladder Carcinoma

Categories: Cancer diseases, Gastrointestinal diseases

Aliases & Classifications for Adenosquamous Gallbladder Carcinoma

MalaCards integrated aliases for Adenosquamous Gallbladder Carcinoma:

Name: Adenosquamous Gallbladder Carcinoma 12 15
Adenosquamous Carcinoma of the Gallbladder 12
Adenosquamous Carcinoma of Gallbladder 12
Gallbladder Adenosquamous Carcinoma 17

Classifications:



External Ids:

Disease Ontology 12 DOID:5627
NCIt 51 C7356
UMLS 74 C1333741

Summaries for Adenosquamous Gallbladder Carcinoma

Disease Ontology : 12 A gallbladder carcinoma that derives from squamous cells and gland-like cells.

MalaCards based summary : Adenosquamous Gallbladder Carcinoma, also known as adenosquamous carcinoma of the gallbladder, is related to gallbladder cancer and adenocarcinoma. An important gene associated with Adenosquamous Gallbladder Carcinoma is SERPINA3 (Serpin Family A Member 3), and among its related pathways/superpathways is Autophagy - animal. Affiliated tissues include colon, bone and breast, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Related Diseases for Adenosquamous Gallbladder Carcinoma

Diseases related to Adenosquamous Gallbladder Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 12)
# Related Disease Score Top Affiliating Genes
1 gallbladder cancer 10.2
2 adenocarcinoma 10.1
3 adenosquamous carcinoma 10.1
4 xanthogranulomatous cholecystitis 10.0 CEACAM5 SERPINA3
5 breast cyst 9.9 CTSD SERPINA3
6 testicular yolk sac tumor 9.9 CEACAM5 SERPINA3
7 alzheimer disease 2 9.9 CTSD SERPINA3
8 colonic disease 9.8 CEACAM5 CTSD
9 fibrosarcoma of bone 9.8 PDGFRA SERPINA3
10 rosai-dorfman disease 9.7 CTSD PDGFRA
11 dermatofibrosarcoma protuberans 9.7 PDGFRA SERPINA3
12 gastrointestinal system cancer 9.5 CEACAM5 PDGFRA

Graphical network of the top 20 diseases related to Adenosquamous Gallbladder Carcinoma:



Diseases related to Adenosquamous Gallbladder Carcinoma

Symptoms & Phenotypes for Adenosquamous Gallbladder Carcinoma

GenomeRNAi Phenotypes related to Adenosquamous Gallbladder Carcinoma according to GeneCards Suite gene sharing:

27 (show all 11)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-105 9.4 CTSD
2 Increased shRNA abundance (Z-score > 2) GR00366-A-115 9.4 CTSD
3 Increased shRNA abundance (Z-score > 2) GR00366-A-146 9.4 CTSD
4 Increased shRNA abundance (Z-score > 2) GR00366-A-163 9.4 HMGB1
5 Increased shRNA abundance (Z-score > 2) GR00366-A-176 9.4 HMGB1
6 Increased shRNA abundance (Z-score > 2) GR00366-A-6 9.4 CTSD HMGB1
7 Increased shRNA abundance (Z-score > 2) GR00366-A-69 9.4 HMGB1
8 Increased shRNA abundance (Z-score > 2) GR00366-A-73 9.4 CTSD
9 Increased shRNA abundance (Z-score > 2) GR00366-A-81 9.4 HMGB1
10 Increased shRNA abundance (Z-score > 2) GR00366-A-85 9.4 CTSD
11 Increased shRNA abundance (Z-score > 2) GR00366-A-99 9.4 CTSD

Drugs & Therapeutics for Adenosquamous Gallbladder Carcinoma

Search Clinical Trials , NIH Clinical Center for Adenosquamous Gallbladder Carcinoma

Genetic Tests for Adenosquamous Gallbladder Carcinoma

Anatomical Context for Adenosquamous Gallbladder Carcinoma

MalaCards organs/tissues related to Adenosquamous Gallbladder Carcinoma:

42
Colon, Bone, Breast

Publications for Adenosquamous Gallbladder Carcinoma

Articles related to Adenosquamous Gallbladder Carcinoma:

(show all 12)
# Title Authors Year
1
Adenosquamous gallbladder carcinoma: Multigene hotspot mutational profiling reveals a monoclonal origin of the two components. ( 28698100 )
2017
2
Surgical resection of splenic metastasis from the adenosquamous gallbladder carcinoma: A case report. ( 26852359 )
2016
3
Squamous/adenosquamous carcinoma of the gallbladder: Analysis of 34 cases and comparison of clinicopathologic features and surgical outcomes with adenocarcinoma. ( 26458491 )
2015
4
Long-term survival of a patient with advanced adenosquamous carcinoma of the gallbladder after radical resection. ( 15868080 )
2005
5
Adenosquamous carcinoma of the gallbladder. ( 12239911 )
2002
6
Adenosquamous carcinoma of the gallbladder warrants resection only if curative resection is feasible. ( 12115390 )
2002
7
Advanced adenosquamous carcinoma of the gallbladder with bilio-biliary fistula: an uncommon case treated by hepatopancreatoduodenectomy. ( 10430314 )
1999
8
MRI findings in adenosquamous carcinoma of the gallbladder. ( 9543592 )
1998
9
Hepatopancreatoduodenectomy for squamous and adenosquamous carcinoma of the gallbladder. ( 7782034 )
1995
10
Adenosquamous carcinoma of the gallbladder: a clinicopathological, immunohistochemical and flow-cytometric study of twenty cases. ( 7911122 )
1994
11
Stromal osteoclast-like giant cells in an adenosquamous carcinoma of the gallbladder. ( 1592394 )
1992
12
Adenosquamous carcinoma of the gallbladder with spindle cell features. A light microscopic and immunocytochemical study of a case. ( 2437004 )
1987

Variations for Adenosquamous Gallbladder Carcinoma

Expression for Adenosquamous Gallbladder Carcinoma

Search GEO for disease gene expression data for Adenosquamous Gallbladder Carcinoma.

Pathways for Adenosquamous Gallbladder Carcinoma

Pathways related to Adenosquamous Gallbladder Carcinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.73 CTSD HMGB1

GO Terms for Adenosquamous Gallbladder Carcinoma

Cellular components related to Adenosquamous Gallbladder Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.56 CEACAM5 CTSD HMGB1 SERPINA3
2 ficolin-1-rich granule lumen GO:1904813 9.16 CTSD HMGB1
3 secretory granule lumen GO:0034774 8.96 HMGB1 SERPINA3
4 cell surface GO:0009986 8.8 CEACAM5 HMGB1 PDGFRA

Biological processes related to Adenosquamous Gallbladder Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 chemotaxis GO:0006935 9.37 HMGB1 PDGFRA
2 positive regulation of cytosolic calcium ion concentration GO:0007204 9.32 HMGB1 PDGFRA
3 positive regulation of MAPK cascade GO:0043410 9.26 HMGB1 PDGFRA
4 cell chemotaxis GO:0060326 8.96 HMGB1 PDGFRA
5 lung development GO:0030324 8.85 PDGFRA
6 neutrophil degranulation GO:0043312 8.8 CTSD HMGB1 SERPINA3

Sources for Adenosquamous Gallbladder Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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