MCID: ADN008
MIFTS: 38

Adenosquamous Pancreas Carcinoma

Categories: Cancer diseases, Endocrine diseases

Aliases & Classifications for Adenosquamous Pancreas Carcinoma

MalaCards integrated aliases for Adenosquamous Pancreas Carcinoma:

Name: Adenosquamous Pancreas Carcinoma 12 15
Adenosquamous Carcinoma of the Pancreas 12
Adenosquamous Carcinoma of Pancreas 12

Classifications:



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Disease Ontology 12 DOID:5637
NCIt 50 C5721
UMLS 73 C1335299

Summaries for Adenosquamous Pancreas Carcinoma

Disease Ontology : 12 A pancreatic ductal carcinoma that derives from squamous cells and gland-like cells.

MalaCards based summary : Adenosquamous Pancreas Carcinoma, also known as adenosquamous carcinoma of the pancreas, is related to adenosquamous carcinoma and sigmoid neoplasm. An important gene associated with Adenosquamous Pancreas Carcinoma is PTHLH (Parathyroid Hormone Like Hormone), and among its related pathways/superpathways are PEDF Induced Signaling and Developmental Biology. Affiliated tissues include pancreas, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Related Diseases for Adenosquamous Pancreas Carcinoma

Diseases related to Adenosquamous Pancreas Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 78)
# Related Disease Score Top Affiliating Genes
1 adenosquamous carcinoma 29.9 KRAS KRT5 KRT7 PTHLH
2 sigmoid neoplasm 10.8 HRAS KRAS
3 apocrine adenoma 10.7 HRAS KRAS
4 schimmelpenning-feuerstein-mims syndrome 10.7 HRAS KRAS
5 periampullary adenoma 10.7 HRAS KRAS
6 paronychia 10.7 HRAS KRAS
7 bile duct cysts 10.6 HRAS KRAS
8 aggressive digital papillary adenocarcinoma 10.5 HRAS KRAS
9 pyogenic granuloma 10.5 ANGPT1 TEK
10 mutyh-associated polyposis 10.5 KRAS SMAD4
11 st. louis encephalitis 10.4 IFNA2 KRAS
12 secondary hypertrophic osteoarthropathy 10.4 HRAS KRAS
13 inverted transitional papilloma 10.4 KRT5 KRT7
14 balloon cell malignant melanoma 10.4 KRT5 KRT7
15 benign breast adenomyoepithelioma 10.4 KRT5 KRT7
16 malignant spiradenoma 10.4 KRT5 KRT7
17 sensory organ benign neoplasm 10.3 KRT5 KRT7
18 colloid carcinoma of the pancreas 10.3 HRAS KRAS SMAD4
19 malignant conjunctival melanoma 10.3 HRAS IFNA2
20 bile duct mucoepidermoid carcinoma 10.3 KRT5 KRT7
21 middle ear adenoma 10.3 KRT5 KRT7
22 bronchiolo-alveolar adenocarcinoma 10.3 KRAS KRT7
23 large cell acanthoma 10.3 KRT5 KRT7
24 endocrine gland cancer 10.3 HRAS KRAS SMAD4
25 papillary adenoma 10.2 KRT5 KRT7
26 adenocarcinoma in situ 10.2 KRAS KRT7 TOP2A
27 apocrine sweat gland neoplasm 10.2 KRT5 KRT7
28 pancreas adenocarcinoma 10.2 HRAS KRAS SMAD4
29 nasal cavity adenocarcinoma 10.2 HRAS KRAS KRT7
30 anal canal adenocarcinoma 10.2 HRAS KRAS KRT7
31 ampulla of vater neoplasm 10.2 HRAS KRAS KRT7
32 biliary papillomatosis 10.2 HRAS KRAS KRT7
33 ovary adenocarcinoma 10.2 HRAS KRAS KRT7
34 duodenum cancer 10.2 HRAS KRAS KRT7
35 cecum adenocarcinoma 10.2 HRAS KRAS KRT7
36 pilocytic astrocytoma 10.2 HRAS KRAS MGMT
37 bile duct adenocarcinoma 10.2 HRAS KRAS KRT7
38 gastrointestinal system benign neoplasm 10.2 HRAS KRAS KRT7
39 lung benign neoplasm 10.2 HRAS KRAS KRT7
40 apocrine adenocarcinoma 10.2 KRT5 KRT7
41 chronic myocardial ischemia 10.2 ANGPT1 TEK
42 ovarian cancer 1 10.2 HRAS KRAS KRT7
43 malignant ovarian surface epithelial-stromal neoplasm 10.2 HRAS KRAS KRT7
44 ovary epithelial cancer 10.2 HRAS KRAS KRT7
45 cell type benign neoplasm 10.2 HRAS KRAS KRT7
46 colorectal adenocarcinoma 10.2 HRAS KRAS KRT7
47 rectal neoplasm 10.1 HRAS KRAS KRT7
48 anus cancer 10.1 KRAS KRT5 KRT7
49 large cell carcinoma 10.1 KRT5 KRT7 PTHLH
50 breast squamous cell carcinoma 10.1 KRT5 PTHLH

Graphical network of the top 20 diseases related to Adenosquamous Pancreas Carcinoma:



Diseases related to Adenosquamous Pancreas Carcinoma

Symptoms & Phenotypes for Adenosquamous Pancreas Carcinoma

GenomeRNAi Phenotypes related to Adenosquamous Pancreas Carcinoma according to GeneCards Suite gene sharing:

26 (show all 31)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-100 10.17 HIF1A
2 Increased shRNA abundance (Z-score > 2) GR00366-A-105 10.17 IFNA2
3 Increased shRNA abundance (Z-score > 2) GR00366-A-11 10.17 KRAS
4 Increased shRNA abundance (Z-score > 2) GR00366-A-120 10.17 KRAS
5 Increased shRNA abundance (Z-score > 2) GR00366-A-127 10.17 IFNA2
6 Increased shRNA abundance (Z-score > 2) GR00366-A-135 10.17 RRM1
7 Increased shRNA abundance (Z-score > 2) GR00366-A-161 10.17 HIF1A
8 Increased shRNA abundance (Z-score > 2) GR00366-A-168 10.17 KRAS HIF1A RRM1 IFNA2
9 Increased shRNA abundance (Z-score > 2) GR00366-A-174 10.17 HIF1A
10 Increased shRNA abundance (Z-score > 2) GR00366-A-177 10.17 KRAS
11 Increased shRNA abundance (Z-score > 2) GR00366-A-178 10.17 IFNA2
12 Increased shRNA abundance (Z-score > 2) GR00366-A-182 10.17 HIF1A
13 Increased shRNA abundance (Z-score > 2) GR00366-A-185 10.17 HIF1A
14 Increased shRNA abundance (Z-score > 2) GR00366-A-196 10.17 KRAS
15 Increased shRNA abundance (Z-score > 2) GR00366-A-199 10.17 HIF1A
16 Increased shRNA abundance (Z-score > 2) GR00366-A-201 10.17 RRM1
17 Increased shRNA abundance (Z-score > 2) GR00366-A-23 10.17 KRAS
18 Increased shRNA abundance (Z-score > 2) GR00366-A-25 10.17 IFNA2
19 Increased shRNA abundance (Z-score > 2) GR00366-A-29 10.17 IFNA2
20 Increased shRNA abundance (Z-score > 2) GR00366-A-43 10.17 RRM1
21 Increased shRNA abundance (Z-score > 2) GR00366-A-46 10.17 RRM1
22 Increased shRNA abundance (Z-score > 2) GR00366-A-49 10.17 KRAS
23 Increased shRNA abundance (Z-score > 2) GR00366-A-50 10.17 KRAS
24 Increased shRNA abundance (Z-score > 2) GR00366-A-57 10.17 RRM1
25 Increased shRNA abundance (Z-score > 2) GR00366-A-63 10.17 KRAS HIF1A
26 Increased shRNA abundance (Z-score > 2) GR00366-A-79 10.17 HIF1A
27 Increased shRNA abundance (Z-score > 2) GR00366-A-85 10.17 RRM1
28 Increased shRNA abundance (Z-score > 2) GR00366-A-90 10.17 RRM1
29 Increased shRNA abundance (Z-score > 2) GR00366-A-93 10.17 KRAS
30 Increased mitotic index GR00110-A-0 9.33 MET SMAD4 TEK
31 Reduced mammosphere formation GR00396-S 9.17 KRAS KRT7 RRM1 HRAS IFNA17 SMAD4

MGI Mouse Phenotypes related to Adenosquamous Pancreas Carcinoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.03 HRAS PTHLH KRAS ANGPT1 HIF1A MET
2 homeostasis/metabolism MP:0005376 10.02 HRAS PTHLH KRAS ANGPT1 KRT7 HIF1A
3 craniofacial MP:0005382 9.95 PTHLH KRAS SMAD4 KRT5 HIF1A MET
4 digestive/alimentary MP:0005381 9.91 PTHLH KRAS SMAD4 KRT5 HIF1A MET
5 mortality/aging MP:0010768 9.9 PTHLH KRAS RRM1 SMAD4 KRT5 ANGPT1
6 limbs/digits/tail MP:0005371 9.73 PTHLH KRAS KRT5 HIF1A MET SMAD4
7 neoplasm MP:0002006 9.43 HRAS KRAS HIF1A MET MGMT SMAD4
8 renal/urinary system MP:0005367 9.23 KRAS SMAD4 ANGPT1 KRT7 HIF1A MET

Drugs & Therapeutics for Adenosquamous Pancreas Carcinoma

Search Clinical Trials , NIH Clinical Center for Adenosquamous Pancreas Carcinoma

Genetic Tests for Adenosquamous Pancreas Carcinoma

Anatomical Context for Adenosquamous Pancreas Carcinoma

MalaCards organs/tissues related to Adenosquamous Pancreas Carcinoma:

41
Pancreas

Publications for Adenosquamous Pancreas Carcinoma

Articles related to Adenosquamous Pancreas Carcinoma:

(show all 48)
# Title Authors Year
1
Comparative outcomes of adenosquamous carcinoma of the pancreas: An analysis of the National Cancer Database. ( 29878370 )
2018
2
Adenosquamous Carcinoma of the Pancreas Demonstrated on 18F-FDG PET/CT Imaging. ( 28098663 )
2017
3
Clinical implications of the proliferative ability of the squamous component regarding tumor progression of adenosquamous carcinoma of the pancreas: A preliminary report. ( 28784574 )
2017
4
Recent advances in genomic profiling of adenosquamous carcinoma of the pancreas. ( 28816351 )
2017
5
Nab-paclitaxel+gemcitabine therapy for adenosquamous carcinoma of the pancreas: an autopsy case. ( 27725467 )
2016
6
Adenosquamous carcinoma of the pancreas: Molecular characterization of 23 patients along with a literature review. ( 26380056 )
2015
7
Efficacy of platinum chemotherapy agents in the adjuvant setting for adenosquamous carcinoma of the pancreas. ( 25830031 )
2015
8
Clinicopathological features and surgical outcomes of adenosquamous carcinoma of the pancreas: a retrospective analysis of patients with resectable stage tumors. ( 24973941 )
2014
9
A huge adenosquamous carcinoma of the pancreas with sarcomatoid change: an unusual case report. ( 25473201 )
2014
10
Ring-enhancement pattern on contrast-enhanced CT predicts adenosquamous carcinoma of the pancreas: a matched case-control study. ( 24854619 )
2014
11
Characteristics and outcomes of adenosquamous carcinoma of the pancreas. ( 23936547 )
2013
12
Adenosquamous carcinoma of the pancreas: multidetector-row computed tomographic manifestations and tumor characteristics. ( 23493198 )
2013
13
Contrast-enhanced multiphasic CT and MRI findings of adenosquamous carcinoma of the pancreas. ( 24035524 )
2013
14
415 patients with adenosquamous carcinoma of the pancreas: a population-based analysis of prognosis and survival. ( 21816433 )
2012
15
Massive upper gastrointestinal hemorrhage due to adenosquamous carcinoma of the pancreas: Case report and literature review. ( 22811837 )
2011
16
Adenosquamous carcinoma of the pancreas: a case report. ( 20205828 )
2010
17
Adenosquamous carcinoma of the pancreas: a distinct clinicopathologic entity. ( 20697320 )
2010
18
Electronic image of the month. Adenosquamous carcinoma of the pancreas. ( 20005983 )
2010
19
Adenosquamous carcinoma of the pancreas, a rare tumor entity: a case report. ( 20062646 )
2009
20
Adenosquamous carcinoma of the pancreas harbors KRAS2, DPC4 and TP53 molecular alterations similar to pancreatic ductal adenocarcinoma. ( 19270646 )
2009
21
Surgical outcome of adenosquamous carcinoma of the pancreas. ( 19058301 )
2008
22
Education of imaging. Hepatobiliary and pancreatic: adenosquamous carcinoma of the pancreas. ( 18410615 )
2008
23
Adenosquamous carcinoma of the pancreas: a single-institution experience comparing resection and palliative care. ( 18722942 )
2008
24
Adenosquamous carcinoma of the pancreas associated with humoral hypercalcemia of malignancy (HHM). ( 18836809 )
2008
25
Adenosquamous carcinoma of the pancreas with clear cell and rhabdoid components. A case report. ( 17495363 )
2007
26
Adenosquamous carcinoma of the pancreas. ( 16172546 )
2005
27
Adenosquamous carcinoma of the pancreas with an acantholytic pattern together with osteoclast-like and pleomorphic giant cells. ( 16126885 )
2005
28
Adenosquamous carcinoma of the pancreas: preoperative diagnosis and molecular alterations. ( 14714256 )
2003
29
Adenosquamous carcinoma of the pancreas: cytologic features in 14 cases. ( 14681946 )
2003
30
Adenosquamous Carcinoma of the Pancreas: Successful Treatment with Extended Radical Surgery, Intraoperative Radiation Therapy, and Locoregional Chemotherapy. ( 12754405 )
2001
31
Adenosquamous carcinoma of the pancreas: successful treatment with extended radical surgery, intraoperative radiation therapy, and locoregional chemotherapy. ( 11558633 )
2001
32
Adenosquamous carcinoma of the pancreas: a clinicopathologic series of 25 cases. ( 11353055 )
2001
33
Adenosquamous carcinoma of the pancreas: report of two cases. ( 10926197 )
2000
34
Adenosquamous carcinoma of the pancreas. ( 10367867 )
1999
35
Adenosquamous carcinoma of the pancreas: differentiation from pancreatic pseudocyst. ( 9609438 )
1998
36
Adenosquamous carcinoma of the pancreas: report of two cases. ( 9672355 )
1998
37
Intense Ga-67 uptake in adenosquamous carcinoma of the pancreas. ( 9095322 )
1997
38
Adenosquamous carcinoma of the pancreas. ( 8963403 )
1995
39
Response of adenosquamous carcinoma of the pancreas to interferon-alpha, tumor necrosis factor-alpha and 5-fluorouracil combined treatment. ( 7872711 )
1994
40
Pancreatic cytology and adenosquamous carcinoma of the pancreas. ( 8165013 )
1993
41
Adenosquamous carcinoma of the pancreas. ( 8355892 )
1993
42
Immunohistochemical characteristics of adenosquamous carcinoma of the pancreas. ( 1372374 )
1992
43
Adenosquamous carcinoma of the pancreas: a clinicopathologic study. ( 2062081 )
1991
44
Cytodiagnosis of adenosquamous carcinoma of the pancreas. Use of intraoperative fine needle aspiration. ( 6594886 )
1984
45
Adenosquamous carcinoma of the pancreas. ( 6879736 )
1983
46
Adenosquamous carcinoma of the pancreas: a light and electron microscopic study. ( 7071952 )
1982
47
Adenosquamous carcinoma of the pancreas: a clinicopathologic study and report of three cases. ( 7214302 )
1980
48
Adenoacanthoma (adenosquamous carcinoma) of the pancreas. ( 5021607 )
1972

Variations for Adenosquamous Pancreas Carcinoma

Expression for Adenosquamous Pancreas Carcinoma

Search GEO for disease gene expression data for Adenosquamous Pancreas Carcinoma.

Pathways for Adenosquamous Pancreas Carcinoma

Pathways related to Adenosquamous Pancreas Carcinoma according to GeneCards Suite gene sharing:

(show all 38)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.53 ANGPT1 HRAS IFNA17 IFNA2 KRAS MET
2
Show member pathways
13.29 ANGPT1 HRAS KRAS KRT5 KRT7 MET
3
Show member pathways
13.27 ANGPT1 HRAS IFNA17 IFNA2 KRAS MET
4
Show member pathways
13.2 ANGPT1 HRAS IFNA17 IFNA2 KRAS TEK
5
Show member pathways
13.17 ANGPT1 HRAS KRAS MET SMAD4 TEK
6
Show member pathways
13.08 ANGPT1 HIF1A HRAS IFNA17 IFNA2 KRAS
7 12.63 ANGPT1 HRAS KRAS MET TEK
8
Show member pathways
12.63 ANGPT1 HRAS IFNA17 IFNA2 KRAS MET
9
Show member pathways
12.59 ANGPT1 HRAS KRAS MET TEK
10
Show member pathways
12.48 ANGPT1 HRAS KRAS TEK
11
Show member pathways
12.39 HRAS IFNA17 IFNA2 KRAS
12
Show member pathways
12.35 HIF1A HRAS KRAS MET
13 12.22 HIF1A HRAS IFNA17 IFNA2 KRAS MET
14 12.16 HIF1A HRAS KRAS MET
15
Show member pathways
12.15 HIF1A HRAS IFNA17 IFNA2 KRAS SMAD4
16
Show member pathways
12.09 ANGPT1 HRAS KRAS TEK
17 12.03 HRAS KRAS MET TEK
18 11.99 HRAS KRAS SMAD4
19
Show member pathways
11.99 HRAS KRAS SMAD4
20 11.98 HRAS KRAS SMAD4
21
Show member pathways
11.96 KRAS MET TEK
22
Show member pathways
11.95 HIF1A HRAS KRAS
23 11.94 HIF1A HRAS KRAS
24
Show member pathways
11.93 ANGPT1 HRAS KRAS MET SMAD4
25 11.9 HIF1A HRAS KRAS
26 11.89 HRAS KRAS SMAD4
27 11.88 HRAS IFNA17 IFNA2 KRAS
28 11.86 HRAS KRAS MGMT
29 11.8 ANGPT1 HIF1A TEK
30 11.79 HRAS KRAS SMAD4
31 11.74 HRAS IFNA17 IFNA2 KRAS
32 11.57 HIF1A HRAS KRAS
33 11.44 HIF1A HRAS KRAS MET
34 11.25 ANGPT1 HRAS TEK
35 10.97 HRAS KRAS
36 10.96 ANGPT1 HIF1A TEK
37 10.74 HRAS KRAS
38 10.4 HRAS KRAS MET SMAD4

GO Terms for Adenosquamous Pancreas Carcinoma

Biological processes related to Adenosquamous Pancreas Carcinoma according to GeneCards Suite gene sharing:

(show all 17)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of apoptotic process GO:0043066 9.85 ANGPT1 HIF1A MET MGMT TEK
2 cytokine-mediated signaling pathway GO:0019221 9.8 HIF1A IFNA17 IFNA2 KRAS
3 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.73 ANGPT1 HRAS MET TEK
4 transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 9.71 ANGPT1 MET TEK
5 leukocyte migration GO:0050900 9.67 ANGPT1 HRAS KRAS TEK
6 regulation of long-term neuronal synaptic plasticity GO:0048169 9.57 HRAS KRAS
7 positive regulation of peptidyl-serine phosphorylation of STAT protein GO:0033141 9.56 IFNA17 IFNA2
8 positive regulation of nitric-oxide synthase activity GO:0051000 9.55 HIF1A KRAS
9 natural killer cell activation involved in immune response GO:0002323 9.52 IFNA17 IFNA2
10 positive regulation of actin cytoskeleton reorganization GO:2000251 9.51 HRAS TEK
11 DNA ligation GO:0006266 9.48 MGMT TOP2A
12 response to isolation stress GO:0035900 9.4 HRAS KRAS
13 glomerulus vasculature development GO:0072012 9.32 ANGPT1 TEK
14 regulation of transforming growth factor beta2 production GO:0032909 9.26 HIF1A SMAD4
15 negative regulation of neuron apoptotic process GO:0043524 9.26 ANGPT1 HIF1A HRAS KRAS
16 Tie signaling pathway GO:0048014 9.16 ANGPT1 TEK
17 MAPK cascade GO:0000165 9.02 ANGPT1 HRAS KRAS MET TEK

Molecular functions related to Adenosquamous Pancreas Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nucleotide binding GO:0000166 9.46 HRAS KRAS MET TEK
2 type I interferon receptor binding GO:0005132 8.96 IFNA17 IFNA2
3 Ras guanyl-nucleotide exchange factor activity GO:0005088 8.8 ANGPT1 MET TEK

Sources for Adenosquamous Pancreas Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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