MCID: ADH001
MIFTS: 36

Adhesions of Uterus

Categories: Reproductive diseases

Aliases & Classifications for Adhesions of Uterus

MalaCards integrated aliases for Adhesions of Uterus:

Name: Adhesions of Uterus 12 15 71
Intrauterine Adhesions 12 71
Intrauterine Synechiae 12 32
Asherman Syndrome 71
Band of Uterus 12

Classifications:



External Ids:

Disease Ontology 12 DOID:13812
SNOMED-CT 67 301789000
ICD10 32 N85.6
UMLS 71 C0156372 C0241593 C1704274

Summaries for Adhesions of Uterus

Disease Ontology : 12 A uterine disease that is characterized by the presence of scar tissue which attaches the uterus to another structure.

MalaCards based summary : Adhesions of Uterus, also known as intrauterine adhesions, is related to myoma and adenomyosis. An important gene associated with Adhesions of Uterus is MFN2 (Mitofusin 2). The drugs Dimenhydrinate and Estradiol have been mentioned in the context of this disorder. Affiliated tissues include uterus, bone marrow and bone, and related phenotypes are decreased fertility in females and oligomenorrhea

Related Diseases for Adhesions of Uterus

Diseases related to Adhesions of Uterus via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 45)
# Related Disease Score Top Affiliating Genes
1 myoma 29.8 PGR MFN2 HOXA10 AMH
2 adenomyosis 29.2 PGR HOXA10
3 asherman's syndrome 11.5
4 amenorrhea 10.4
5 infertility 10.4
6 salpingo-oophoritis 10.3 MFN2 AMH
7 salpingitis isthmica nodosa 10.3 MFN2 AMH
8 salpingitis 10.2 MFN2 AMH
9 endometrial cancer 10.1
10 endometritis 10.1
11 placenta disease 10.1
12 subserous uterine fibroid 10.1 PGR AMH
13 constricting bands, congenital 10.0
14 endometrial adenocarcinoma 10.0
15 endometrial disease 10.0 PGR MFN2
16 endometriosis of ovary 10.0 PGR AMH
17 fibrosis of extraocular muscles, congenital, 1 10.0
18 leukemia, acute lymphoblastic 3 10.0
19 placenta accreta 10.0
20 48,xyyy 10.0
21 sex cord-gonadal stromal tumor 10.0 PGR AMH
22 gonadoblastoma 9.9 POU5F1 AMH
23 uterine anomalies 9.9
24 ectopic pregnancy 9.9
25 leiomyoma 9.9
26 myofibroma 9.9
27 ovarian clear cell adenocarcinoma 9.8 PGR HOXA10
28 cryptorchidism, unilateral or bilateral 9.8 POU5F1 HOXA10 AMH
29 ocular motor apraxia 9.7
30 premature ovarian failure 1 9.7
31 endometrial hyperplasia 9.7
32 vaginal cancer 9.7
33 reproductive system disease 9.7
34 endometriosis 9.7
35 hyperglycemia 9.7
36 keratinizing squamous cell carcinoma 9.7
37 severe combined immunodeficiency 9.7
38 cervical incompetence 9.7
39 hemometra 9.7
40 cytokine deficiency 9.7
41 rapidly involuting congenital hemangioma 9.7
42 overgrowth syndrome 9.7
43 pelvic organ prolapse 9.7 PGR MFN2
44 uterine benign neoplasm 9.6 PGR MFN2 HOXA10 AMH
45 reproductive organ benign neoplasm 9.6 PGR MFN2 HOXA10 AMH

Graphical network of the top 20 diseases related to Adhesions of Uterus:



Diseases related to Adhesions of Uterus

Symptoms & Phenotypes for Adhesions of Uterus

Human phenotypes related to Adhesions of Uterus:

31 (show all 10)
# Description HPO Frequency HPO Source Accession
1 decreased fertility in females 31 frequent (33%) HP:0000868
2 oligomenorrhea 31 frequent (33%) HP:0000876
3 secondary amenorrhea 31 occasional (7.5%) HP:0000869
4 infertility 31 occasional (7.5%) HP:0000789
5 dysmenorrhea 31 occasional (7.5%) HP:0100607
6 spontaneous abortion 31 occasional (7.5%) HP:0005268
7 metrorrhagia 31 occasional (7.5%) HP:0100608
8 episodic abdominal pain 31 occasional (7.5%) HP:0002574
9 abnormality of the placenta 31 very rare (1%) HP:0100767
10 chronic infection 31 very rare (1%) HP:0031035

MGI Mouse Phenotypes related to Adhesions of Uterus:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.5 CCN2 HOXA10 KDM6A MCAM MFN2 NUS1
2 embryo MP:0005380 9.17 ARHGAP29 CCN2 KDM6A MFN2 NUS1 PGR

Drugs & Therapeutics for Adhesions of Uterus

Drugs for Adhesions of Uterus (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 44)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dimenhydrinate Approved Phase 4 523-87-5 441281
2
Estradiol Approved, Investigational, Vet_approved Phase 4 50-28-2 5757
3
Polyestradiol phosphate Approved Phase 4 28014-46-2
4 Carboxymethylcellulose Sodium Phase 4
5 Progestins Phase 4
6 Estradiol 17 beta-cypionate Phase 4
7 Hormone Antagonists Phase 4
8 Estradiol 3-benzoate Phase 4
9 Contraceptive Agents Phase 4
10 Hormones Phase 4
11
Tacrolimus Approved, Investigational Phase 3 104987-11-3 445643 439492 6473866
12 Immunologic Factors Phase 3
13 Immunosuppressive Agents Phase 3
14 Calcineurin Inhibitors Phase 3
15 Estrogens Phase 1
16 Pharmaceutical Solutions Phase 1
17 Anesthetics Phase 1
18 Anti-Bacterial Agents Phase 1
19 Antibiotics, Antitubercular Phase 1
20
Lenograstim Approved, Investigational 135968-09-1
21
Aspirin Approved, Vet_approved 50-78-2 2244
22
Ethanol Approved Early Phase 1 64-17-5 702
23
Hyaluronic acid Approved, Vet_approved 9004-61-9 53477741
24
Progesterone Approved, Vet_approved 57-83-0 5994
25
Zaleplon Approved, Illicit, Investigational 151319-34-5 5719
26
Iodine Approved, Investigational 7553-56-2 807
27
Povidone Approved 9003-39-8
28
Sargramostim Approved, Investigational 83869-56-1, 123774-72-1
29
carbamide peroxide Approved 124-43-6
30
Povidone-iodine Approved 25655-41-8
31
Lidocaine Approved, Vet_approved 137-58-6 3676
32
Medroxyprogesterone acetate Approved, Investigational 71-58-9
33
Prednisone Approved, Vet_approved 53-03-2 5865
34
Mycophenolic acid Approved 24280-93-1 446541
35
Azathioprine Approved 446-86-6 2265
36 Molgramostim Investigational 99283-10-0
37
Imidacloprid Vet_approved 105827-78-9 86418
38 Adjuvants, Immunologic
39 Viscosupplements
40 Protective Agents
41 Calamus
42 cadexomer iodine
43
Medroxyprogesterone 520-85-4 10631
44 Thymoglobulin

Interventional clinical trials:

(show top 50) (show all 57)
# Name Status NCT ID Phase Drugs
1 The Role of Seprafilm Bioresorbable Slurry in the Prevention of Intrauterine Synechiae in Patients Undergoing Hysteroscopic Myomectomy Unknown status NCT01632202 Phase 4
2 Effectiveness of Self-cross-linked Hyaluronic Acid Gel in the Prevention of Intrauterine Adhesions After Second Trimester Abortion Unknown status NCT02868437 Phase 4
3 Clinical Study of the Treatment of Infertility Caused by Severe Intrauterine Adhesions by Collagen Scaffold Loaded With Autologous Bone Marrow Stem Cells Unknown status NCT02204358 Phase 4
4 New Therapeutic Approaches to Treat Asherman's Syndrome and Endometrial Atrophy Based in BM Stem Cells Autologous Transplantation Completed NCT02144987 Phase 4
5 The Effect of Estrogen in the Prevention of Adhesion Reformation After Hysteroscopic Adhesiolysis Enrolling by invitation NCT03620929 Phase 4 Estradiol Valerate
6 Uterus Transplantation From Live Donors and From Deceased Donors - Clinical Study Recruiting NCT03277430 Phase 3 Tacrolimus
7 A Multi-center, Randomized, Single-blind, Controlled Clinical Trial of Treatment of Severe Asherman Syndrome by Collagen Scaffold Loaded With Autologous Bone Marrow Mononuclear Cells Unknown status NCT02680366 Phase 2
8 Platelet-Rich Plasma in the Management of Asherman Syndrome Completed NCT04308811 Phase 2
9 A Prospective, Randomized, Controlled Trial Comparing 2 Different Doses of Estrogen Therapy After Hysteroscopic Adhesiolysis as an Adjuvant to Prevent Recurrence of Intrauterine Adhesions Completed NCT02726971 Phase 1, Phase 2 Femoston
10 Platelet-rich Plasma (PRP) for Endometrial Regeneration and Repair: a Prospective Randomised Pilot Study Completed NCT02825849 Phase 2
11 Cesarean Myomectomy : Safety and Risk of Intrauterine Synechiae Completed NCT03095014 Phase 1
12 Clinical Safety Study of Human Embryonic Stem Cell Derived Mesenchymal Cells in the Treatment of Moderate and Severe Intrauterine Adhesions Not yet recruiting NCT04232592 Phase 1
13 Safety and Therapeutic Effect of Human Amniotic Epithelial Cells in Severe Refractory Asherman's Syndrome Not yet recruiting NCT03223454 Phase 1
14 Randomized, Controlled Trial to Assess the Efficacy of Disposable Balloon Uterine Stent Combined With Estrogen or Dried Biological Amnion Graft for the Therapy of Uterine Adhesion Unknown status NCT03346317 estradiol valerate tablets+dydrogesterone tablets
15 Randomized, Controlled Trial to Assess the Efficacy of Estrogen Therapy Combined With Disposable Balloon Uterine Stent and Dried Biological Amnion Graft in the Prevention of Adhesion Reformation After Hysteroscopic Adhesiolysis Unknown status NCT03351205 estradiol valerate tablets+dydrogesterone tablets
16 Randomized, Controlled Trial to Assess the Efficacy of Disposable Balloon Uterine Stent and Foley Catheter in the Prevention of Adhesion Reformation After Hysteroscopic Adhesiolysis Unknown status NCT03330873
17 Randomized, Controlled Trial to Assess the Efficacy of Disposable Balloon Uterine Stent Combined With Estrogen or Dried Biological Amnion Graft in the Prevention of Adhesion Reformation After Hysteroscopic Adhesiolysis Unknown status NCT03329898 estradiol valerate tablets;dydrogesterone Tablets
18 Amnion Graft for Preventing Intrauterine Adhesions Following Hysteroscopic Surgery Unknown status NCT02132104 Femoston
19 The Efficacy of G-CSF Against Adhesion Reformation After Hysteroscopic Adhesiolysis Unknown status NCT02855632 G-CSF;Normal saline;hormone therapy
20 The Efficacy and Safety of the Dried Biological Amnion Graft Following Hysteroscopic Lysis for the Prevention of Postoperative Adhesions in Patients With Intrauterine Adhesions Unknown status NCT02496052 estradiol valerate tablets+dydrogesterone Tablets
21 Prevention of Intrauterine Adhesions After Hysteroscopic Metroplasty With Autocross-linked Hyaluronic Acid Gel Unknown status NCT02404454
22 Randomized, Controlled Trial Comparing Immediate and Delayed Intrauterine Balloon Therapy in the Prevention of Adhesion Reformation After Hysteroscopic Adhesiolysis Unknown status NCT03171454
23 Efficiency of INTERCOAT (Oxiplex/AP Gel) in Preventing Intrauterine Adhesion Formation in Hysteroscopic Surgery - a Prospective Double Blind Randomized Study Unknown status NCT01637974 INTERCOAT administration
24 Effect of Pelvic Floor Muscle Electrophysiologic Therapy on Enhanced Recovery After Gynecologic Surgery Unknown status NCT03524807
25 The Efficacy of Intrauterine Balloon Dilatation Therapy in the Prevention of Adhesion Formation After Hysteroscopicremovalof Multiple Fibroids Unknown status NCT03169478
26 Description of the Uterine Cavity in Patients With Recurrent Miscarriages Unknown status NCT02746588
27 Use Of Hyaluronic Acid Gel To Prevent Intrauterine Adhesions In Hysteroscopic Surgery Unknown status NCT01464528 Early Phase 1 Hyaluronan
28 The Value of Diagnostic Hysterolaparoscopy in Infertile Patients With Normal Hysterosalpingography Unknown status NCT03106012
29 Intercoat (Oxiplex/AP Gel) for Preventing Intrauterine Adhesions Following Operative Hysteroscopy for Suspected Retained Products of Conception - a Prospective Randomized Pilot Study Completed NCT01377779 Oxiplex/AP gel;Normal Saline
30 Impact of Mindfulness Based Stress Reduction on Anxiety, Depression and Quality of Life in Women With Intrauterine Adhesion:a Randomized Controlled Trial. Completed NCT02746679
31 A Randomized Clinical Trial to Assess the Efficacy of Intrauterine Balloon Compared to Intrauterine Contraceptive Device Plus Foley Catheter in the Therapy for Uterine Adhesion After Hysteroscopic Adhesiolysis Completed NCT02867202
32 Reproductive Outcome Affected by Two Adjunctive Treatments in Patients With Infertility Due to Severe Intrauterine Adhesions. Completed NCT02708277
33 Prevention of Postoperative Adhesion Reformation by Intrauterine Balloon Therapy: a Randomized Controlled Trial Completed NCT03131596
34 Prevalence of Chronic Endometritis in Severe Intrauterine Adhesions and Role of Chronic Endometritis in Postoperative Recurrence of Severe Intrauterine Completed NCT02744807
35 The Value of Using Platelet Rich Plasma After Hysteroscopic Lysis of Severe Intrauterine Adhesions (A Randomized Controlled Trial) Completed NCT03541746
36 Autocrosslinked Hyaluronic Acid Gel in Prevention of Intrauterine Adhesions After Bipolar Radiofrequency Endometrial Ablation: a Randomised, Controlled and Double Blind Study Completed NCT01829451
37 Evaluation of Uterine Patency Following Sonography-guided Transcervical Ablation of Fibroids Completed NCT02844920
38 Clinical Study of the Treatment of Infertility Caused by Recurrent Intrauterine Adhesions by Collagen Scaffold Loaded With Umbilical Cord -Derived Mesenchymal Stem Cells (UC-MSCs) Completed NCT02313415
39 The Efficacy of A New Crosslinked Hyaluronan Gel in the Prevention of Postoperative Intrauterine Adhesion After Dilatation and Curettage in Women With Delayed Miscarriage: A Prospective, Randomized, Controlled Trial Completed NCT03353909
40 A Post-Market Clinical Follow-up Study to Investigate the Usability of the CollaGUARD Adhesion Barrier Following Hysteroscopic Adhesiolysis Completed NCT02348541 Early Phase 1
41 Sonohysterography and 3D Ultrasonography Versus Diagnostic Hysteroscopy in Assessment of Uterine Factor in Cases of Female Infertility Completed NCT02399501
42 Biomedical Study of Toxicity, Biodistribution, Expression and Cellular Characterization of Autologous CD133+ Stem Cells From Donors of Hematopoietic Progenitors (IGX1) in Murine Model With Asherman-induced Syndrome. Recruiting NCT03665649
43 Effects of Probiotics and Pelvic Floor Muscle Electrophysiologic Therapy on Endometrium Repair in Patients With Intrauterine Adhesion. Recruiting NCT03969472 probiotics
44 PREvention of Intrauterine Adhesion After Hysteroscopic Surgery With Novel deGradable Film Recruiting NCT04381728
45 Treatment of Intrauterine Adhesions and Its Distribution of Genital Tract Flora Recruiting NCT03731689 Intrauterine lavage therapy;Intrauterine gel-injection therapy
46 Early Outpatient Hysteroscopy Can Prevent Intrauterine Adhesion After Induced Abortion: a Randomized Controlled Trial Recruiting NCT04166500
47 The Cost-effectiveness of Anti-adhesion Treatment With HYALOBARRIER® GEL ENDO Versus no Gel Following the Removal by Hysteroscopy of Endometrial Polyps, Fibroids With Uterine Cavity Deformation, Uterine Septa, Intrauterine Adhesions or Retained Products of Conception for Improving Reproductive Outcome in Women Wishing to Become Pregnant: a Multi-centre, Parallel Group, Superiority, Double-blind, Randomized Controlled Trial Recruiting NCT03880435
48 Endometrial Reconstruction by Human Regenerative Factors Derived From Platelet-Rich Plasma in Mice Models Recruiting NCT03249415
49 Clinical Study of Stem Cells in the Treatment of Thin Endometrium Recruiting NCT03724617 umbilical cord mesenchymal stem cells combined with collagen scaffold
50 Clinical Advantages of Performing Concomitant Office Hysteroscopy and Endometrial Biopsy in Patients With Oligomenorrhea Seeking Infertility Treatment as Compared to Only Endometrial Biopsy: A Prospective Randomized Study Recruiting NCT03545945

Search NIH Clinical Center for Adhesions of Uterus

Genetic Tests for Adhesions of Uterus

Anatomical Context for Adhesions of Uterus

MalaCards organs/tissues related to Adhesions of Uterus:

40
Uterus, Bone Marrow, Bone, Placenta, Cervix

Publications for Adhesions of Uterus

Articles related to Adhesions of Uterus:

(show top 50) (show all 62)
# Title Authors PMID Year
1
Diagnostic and therapeutic options in recurrent implantation failure. 61
32266059 2020
2
The importance of pseudocapsule preservation during hysteroscopic myomectomy. 61
31585677 2019
3
Early Second-Look Hysteroscopy: Prevention and Treatment of Intrauterine Post-surgical Adhesions. 61
31475154 2019
4
Diagnostic significance of chronic endometritis macrotypes differentiation among women with reproductive losses. 61
29264986 2017
5
Hysteroscopic metroplasty for the septate uterus with diode laser: a pilot study. 61
27632410 2016
6
Ultrasound guidance during hysteroscopic myomectomy in G1 and G2 Submucous Myomas: for a safer one step surgery. 61
27267872 2016
7
[Uterine anomalies in women with recurrent pregnancy loss]. 61
26122902 2015
8
[Intrauterine synechiae after use of monopolar resectoscope]. 61
26285485 2015
9
Intrauterine synechiae after myomectomy; laparotomy versus laparoscopy: Non-randomized interventional trial. 61
26000007 2015
10
Role of hysteroscopy and endometrial biopsy in women with unexplained infertility. 61
23872980 2014
11
Does cold loop hysteroscopic myomectomy reduce intrauterine adhesions? A retrospective study. 61
24182410 2014
12
Risk of postpartum uterine synechiae following uterine compression suturing during postpartum haemorrhage. 61
23163583 2013
13
Ultrasound is the optimal choice for guidance in difficult hysteroscopy. 61
22173892 2012
14
Hysteroscopy after uterine fibroid embolization: evaluation of intrauterine findings in 127 patients. 61
22413922 2012
15
Reproduction after myomectomy: comparison of patients with and without second-look laparoscopy. 61
21745136 2012
16
Operative hysteroscopy in a Jamaican cohort. 61
22512221 2011
17
Concomitant NovaSure endometrial ablation and Essure tubal sterilization: a review of 100 cases. 61
21501541 2011
18
Fertility and pregnancy outcomes following conservative treatment for placenta accreta. 61
20833739 2010
19
Pregnancy after hysteroscopic endometrial ablation without endometrial preparation: a report of five cases and a literature review. 61
21056317 2010
20
[Surgical management of intrauterine adhesions: is benefice bigger than risk?]. 61
20728396 2010
21
[Hysteroscopic evaluation in patients with infertility]. 61
21180876 2010
22
AAGL practice report: practice guidelines for management of intrauterine synechiae. 61
20129325 2010
23
The management of intrauterine synechiae. 61
19550326 2009
24
Uterine rupture resulting from the pressure of an intrauterine balloon. 61
19761638 2009
25
Balloon fluoroscopy as treatment for intrauterine adhesions: a novel approach. 61
18793771 2008
26
Efficiency and pregnancy outcome of serial intrauterine device-guided hysteroscopic adhesiolysis of intrauterine synechiae. 61
18774563 2008
27
Intrauterine adhesions. 61
18756412 2008
28
The uterus and fertility. 61
18155200 2008
29
Radiofrequency global endometrial ablation followed by hysteroscopic sterilization. 61
17630170 2007
30
The evaluation of uterine cavity with saline infusion sonohysterography and hysteroscopy in infertile patients. 61
16891990 2006
31
Uterine devascularization and subsequent major intrauterine synechiae and ovarian failure. 61
15749510 2005
32
Intrapartum spontaneous uterine rupture following uncomplicated resectoscopic treatment of Asherman's syndrome. 61
15880989 2005
33
Vesicouterine fistula and blind vagina. 61
12718783 2003
34
Screening for uterine abnormalities by three-dimensional ultrasound improves perinatal outcome. 61
11933661 2002
35
Three-dimensional ultrasound for routine check-up in in vitro fertilization patients. 61
10962044 2000
36
TRANSVAGINAL SALINE INFUSION SONOHYSTEROGRAPHY: INITIAL RESULTS. 61
28790677 2000
37
Total corporal synechiae due to tuberculosis carry a very poor prognosis following hysteroscopic synechialysis. 61
10438408 1999
38
Transvaginal sonohysterographic evaluation of intrauterine adhesions. 61
10064410 1999
39
The assessment of uterine and ovarian perfusion in infertile patients. 61
9138958 1997
40
Three-dimensional saline contrast hysterosonography and surface rendering of uterine cavity pathology. 61
8916383 1996
41
Comparative Hysteroscopic Findings in Women with Primary and Secondary Infertility 61
9074081 1996
42
Comparison of Operative and Fertility Outcome Between Groups of Women with Intrauterine Adhesions after Adhesiolysis 61
9074216 1996
43
Intrauterine adhesions: hysteroscopic lysis and adjunctive methods. 61
8798308 1996
44
Endometrial carcinoma arising within extensive intrauterine synechiae. 61
7805969 1994
45
Magnetic resonance imaging of intrauterine synechiae. 61
8125415 1994
46
[Diagnostic and therapeutic value of hysteroscopy in intrauterine synechiae]. 61
1491769 1992
47
Ultrasonography's role in detection of intrauterine synechiae. 61
2206063 1990
48
[Hysterographic follow-up of the results of treating uterine synechiae with an intrauterine contraceptive pessary]. 61
2205118 1990
49
Endometrial abnormalities: evaluation with transvaginal sonography. 61
3275446 1988
50
[Model for studying the effect of intrauterine synechiae on the estrous cycle]. 61
4041026 1985

Variations for Adhesions of Uterus

Expression for Adhesions of Uterus

Search GEO for disease gene expression data for Adhesions of Uterus.

Pathways for Adhesions of Uterus

GO Terms for Adhesions of Uterus

Biological processes related to Adhesions of Uterus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 angiogenesis GO:0001525 9.13 NUS1 MCAM CCN2
2 positive regulation of gene expression GO:0010628 8.92 POU5F1 KDM6A CCN2 AMH

Molecular functions related to Adhesions of Uterus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 sequence-specific DNA binding GO:0043565 8.92 POU5F1 PGR KDM6A HOXA10

Sources for Adhesions of Uterus

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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