MCID: ADH001
MIFTS: 31

Adhesions of Uterus

Categories: Reproductive diseases

Aliases & Classifications for Adhesions of Uterus

MalaCards integrated aliases for Adhesions of Uterus:

Name: Adhesions of Uterus 12 15 70
Intrauterine Adhesions 12 70
Intrauterine Synechiae 12 32
Asherman Syndrome 70
Band of Uterus 12

Classifications:



External Ids:

Disease Ontology 12 DOID:13812
SNOMED-CT 67 301789000
ICD10 32 N85.6
UMLS 70 C0156372 C0241593 C1704274

Summaries for Adhesions of Uterus

Disease Ontology : 12 A uterine disease that is characterized by the presence of scar tissue which attaches the uterus to another structure.

MalaCards based summary : Adhesions of Uterus, also known as intrauterine adhesions, is related to asherman's syndrome and amenorrhea. An important gene associated with Adhesions of Uterus is ARHGAP29 (Rho GTPase Activating Protein 29), and among its related pathways/superpathways is Mesodermal Commitment Pathway. The drugs Polyestradiol phosphate and Estradiol have been mentioned in the context of this disorder. Affiliated tissues include uterus, cervix and bone marrow, and related phenotype is digestive/alimentary.

Related Diseases for Adhesions of Uterus

Graphical network of the top 20 diseases related to Adhesions of Uterus:



Diseases related to Adhesions of Uterus

Symptoms & Phenotypes for Adhesions of Uterus

MGI Mouse Phenotypes related to Adhesions of Uterus:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.17 ARHGAP17 ARHGAP29 CCN2 HOXA10 NTSR1 POU5F1

Drugs & Therapeutics for Adhesions of Uterus

Drugs for Adhesions of Uterus (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 46)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Polyestradiol phosphate Approved Phase 4 28014-46-2
2
Estradiol Approved, Investigational, Vet_approved Phase 4 50-28-2 5757
3
Dydrogesterone Approved, Investigational, Withdrawn Phase 4 152-62-5 9051
4
Dimenhydrinate Approved Phase 4 523-87-5 441281
5
Hyaluronic acid Approved, Vet_approved Phase 4 9004-61-9 53477741
6 Hormones Phase 4
7 Estradiol 17 beta-cypionate Phase 4
8 Estradiol 3-benzoate Phase 4
9 Estrogens Phase 4
10 Contraceptive Agents Phase 4
11 Hormone Antagonists Phase 4
12 Progestins Phase 4
13 Protective Agents Phase 4
14 Immunologic Factors Phase 4
15 Viscosupplements Phase 4
16 Adjuvants, Immunologic Phase 4
17 Pharmaceutical Solutions Phase 4
18 Carboxymethylcellulose Sodium Phase 4
19 Antibiotics, Antitubercular Phase 2
20 Anti-Bacterial Agents Phase 2
21
Lenograstim Approved, Investigational 135968-09-1
22
Ethanol Approved Early Phase 1 64-17-5 702
23
Progesterone Approved, Vet_approved 57-83-0 5994
24
Aspirin Approved, Vet_approved 50-78-2 2244
25
Povidone Approved 9003-39-8 131751496
26
Povidone-iodine Approved 25655-41-8
27
Iodine Approved, Investigational 7553-56-2 807
28
Menotropins Approved 9002-68-0, 61489-71-2 5360545
29
Sargramostim Approved, Investigational 123774-72-1, 83869-56-1
30
carbamide peroxide Approved 124-43-6
31
Medroxyprogesterone acetate Approved, Investigational 71-58-9
32
Molgramostim Investigational 99283-10-0
33
Cadexomer iodine Experimental 94820-09-4
34 Analgesics, Non-Narcotic
35 Analgesics
36 Antirheumatic Agents
37 Fibrinolytic Agents
38 Cyclooxygenase Inhibitors
39 Anti-Inflammatory Agents
40 Antipyretics
41 Anti-Inflammatory Agents, Non-Steroidal
42 Platelet Aggregation Inhibitors
43 Calamus
44 Chorionic Gonadotropin
45 Anesthetics
46
Medroxyprogesterone 520-85-4 10631

Interventional clinical trials:

(show top 50) (show all 59)
# Name Status NCT ID Phase Drugs
1 Clinical Study of the Treatment of Infertility Caused by Severe Intrauterine Adhesions by Collagen Scaffold Loaded With Autologous Bone Marrow Stem Cells Unknown status NCT02204358 Phase 4
2 Effectiveness of Self-cross-linked Hyaluronic Acid Gel in the Prevention of Intrauterine Adhesions After Second Trimester Abortion Unknown status NCT02868437 Phase 4
3 Safety of Leaving Cook Balloon Uterine Stent in Uterus for One Month Completed NCT01167296 Phase 4
4 New Therapeutic Approaches to Treat Asherman's Syndrome and Endometrial Atrophy Based in BM Stem Cells Autologous Transplantation Completed NCT02144987 Phase 4
5 The Effect of Estrogen in the Prevention of Adhesion Reformation After Hysteroscopic Adhesiolysis Enrolling by invitation NCT03620929 Phase 4 Estradiol Valerate
6 Prevalence of Intrauterine Adhesions After the Application of Hyaluronic Acid Gel After Dilatation and Curettage in Women With Spontaneous Abortion or Induction of Abortion From 12+0 Till 23+6 Week of Pregnancy. Not yet recruiting NCT04671914 Phase 4 Hyaluronic Acid 20 MG/ML Injectable Solution
7 The Role of Seprafilm Bioresorbable Slurry in the Prevention of Intrauterine Synechiae in Patients Undergoing Hysteroscopic Myomectomy Terminated NCT01632202 Phase 4
8 A Multi-center, Randomized, Single-blind, Controlled Clinical Trial of Treatment of Severe Asherman Syndrome by Collagen Scaffold Loaded With Autologous Bone Marrow Mononuclear Cells Unknown status NCT02680366 Phase 2
9 Platelet-Rich Plasma in the Management of Asherman Syndrome Completed NCT04308811 Phase 2
10 A Prospective, Randomized, Controlled Trial Comparing 2 Different Doses of Estrogen Therapy After Hysteroscopic Adhesiolysis as an Adjuvant to Prevent Recurrence of Intrauterine Adhesions Completed NCT02726971 Phase 1, Phase 2 Femoston
11 Open Randomized Trial of Clinical Efficiency and Safety of Cell Product of Autologous Bone Marrow-derived Mesenchymal Stem Cells for Reparative Treatment of Destructively Changed Endometrium in Patients With Repeated IVF Failures Completed NCT03166189 Phase 2
12 Safety and Therapeutic Effect of Human Amniotic Epithelial Cells in Severe Refractory Asherman's Syndrome Unknown status NCT03223454 Phase 1
13 Cesarean Myomectomy : Safety and Risk of Intrauterine Synechiae Completed NCT03095014 Phase 1
14 Clinical Safety Study of Human Embryonic Stem Cell Derived Mesenchymal Cells in the Treatment of Moderate and Severe Intrauterine Adhesions Not yet recruiting NCT04232592 Phase 1
15 Efficiency of INTERCOAT (Oxiplex/AP Gel) in Preventing Intrauterine Adhesion Formation in Hysteroscopic Surgery - a Prospective Double Blind Randomized Study Unknown status NCT01637974 INTERCOAT administration
16 The Efficacy and Safety of the Dried Biological Amnion Graft Following Hysteroscopic Lysis for the Prevention of Postoperative Adhesions in Patients With Intrauterine Adhesions Unknown status NCT02496052 estradiol valerate tablets+dydrogesterone Tablets
17 Amnion Graft for Preventing Intrauterine Adhesions Following Hysteroscopic Surgery Unknown status NCT02132104 Femoston
18 Prevention of Intrauterine Adhesions After Hysteroscopic Metroplasty With Autocross-linked Hyaluronic Acid Gel Unknown status NCT02404454
19 Randomized, Controlled Trial Comparing Immediate and Delayed Intrauterine Balloon Therapy in the Prevention of Adhesion Reformation After Hysteroscopic Adhesiolysis Unknown status NCT03171454
20 Randomized, Controlled Trial to Assess the Efficacy of Estrogen Therapy Combined With Disposable Balloon Uterine Stent and Dried Biological Amnion Graft in the Prevention of Adhesion Reformation After Hysteroscopic Adhesiolysis Unknown status NCT03351205 estradiol valerate tablets+dydrogesterone tablets
21 The Efficacy of Intrauterine Balloon Dilatation Therapy in the Prevention of Adhesion Formation After Hysteroscopicremovalof Multiple Fibroids Unknown status NCT03169478
22 The Efficacy of G-CSF Against Adhesion Reformation After Hysteroscopic Adhesiolysis Unknown status NCT02855632 G-CSF;Normal saline;hormone therapy
23 Platelet-rich Plasma(PRP) Prevents Recurrence of Intrauterine Adhesions Unknown status NCT03629132
24 Randomized, Controlled Trial to Assess the Efficacy of Disposable Balloon Uterine Stent Combined With Estrogen or Dried Biological Amnion Graft in the Prevention of Adhesion Reformation After Hysteroscopic Adhesiolysis Unknown status NCT03329898 estradiol valerate tablets;dydrogesterone Tablets
25 Randomized, Controlled Trial to Assess the Efficacy of Disposable Balloon Uterine Stent and Foley Catheter in the Prevention of Adhesion Reformation After Hysteroscopic Adhesiolysis Unknown status NCT03330873
26 Randomized, Controlled Trial to Assess the Efficacy of Disposable Balloon Uterine Stent Combined With Estrogen or Dried Biological Amnion Graft for the Therapy of Uterine Adhesion Unknown status NCT03346317 estradiol valerate tablets+dydrogesterone tablets
27 Effect of Pelvic Floor Muscle Electrophysiologic Therapy on Enhanced Recovery After Gynecologic Surgery Unknown status NCT03524807
28 Clinical Study of Stem Cells in the Treatment of Thin Endometrium Unknown status NCT03724617 umbilical cord mesenchymal stem cells combined with collagen scaffold
29 Use Of Hyaluronic Acid Gel To Prevent Intrauterine Adhesions In Hysteroscopic Surgery Unknown status NCT01464528 Early Phase 1 Hyaluronan
30 Prevalence of Chronic Endometritis in Severe Intrauterine Adhesions and Role of Chronic Endometritis in Postoperative Recurrence of Severe Intrauterine Completed NCT02744807
31 Intercoat (Oxiplex/AP Gel) for Preventing Intrauterine Adhesions Following Operative Hysteroscopy for Suspected Retained Products of Conception - a Prospective Randomized Pilot Study Completed NCT01377779 Oxiplex/AP gel;Normal Saline
32 Reproductive Outcome Affected by Two Adjunctive Treatments in Patients With Infertility Due to Severe Intrauterine Adhesions. Completed NCT02708277
33 Impact of Mindfulness Based Stress Reduction on Anxiety, Depression and Quality of Life in Women With Intrauterine Adhesion:a Randomized Controlled Trial. Completed NCT02746679
34 A Placebo Comparative, Evaluator Blinded, Randomized, Multi-center Study to Evaluate the Efficacy and Safety of Medicurtain® in Patients With Hysteroscopy Completed NCT04638855
35 A Randomized, Multi-center, Evaluator and Subject Blind, Active-controlled, Parallel, Medical Device Pivotal Clinical Study to Assess the Anti-adhesive Effect and Safety of ABT13107 Compared to Hyalobarrier Applied to Postoperative Intrauterine Completed NCT04007211
36 Prevention of Postoperative Adhesion Reformation by Intrauterine Balloon Therapy: a Randomized Controlled Trial Completed NCT03131596
37 The Value of Using Platelet Rich Plasma After Hysteroscopic Lysis of Severe Intrauterine Adhesions (A Randomized Controlled Trial) Completed NCT03541746
38 Effects of Aspirin and Intrauterine Balloon on the Post-operative Uterine Endometrial Repair and Reproductive Prognosis in Patients With Severe Intrauterine Adhesion: a Prospective Cohort Study Completed NCT02744716 Aspirin
39 The Efficacy of A New Crosslinked Hyaluronan Gel in the Prevention of Postoperative Intrauterine Adhesion After Dilatation and Curettage in Women With Delayed Miscarriage: A Prospective, Randomized, Controlled Trial Completed NCT03353909
40 PREvention of Intrauterine Adhesion After Hysteroscopic Surgery With Novel deGradable Film Completed NCT04381728
41 A Prospective, Multi-center, Randomized, Controlled Clinical Study on Self-crosslinked Sodium Hyaluronate Gel for Prevention of Intrauterine Adhesion Completed NCT02220621
42 Clinical Study of the Treatment of Infertility Caused by Recurrent Intrauterine Adhesions by Collagen Scaffold Loaded With Umbilical Cord -Derived Mesenchymal Stem Cells (UC-MSCs) Completed NCT02313415
43 Sonohysterography and 3D Ultrasonography Versus Diagnostic Hysteroscopy in Assessment of Uterine Factor in Cases of Female Infertility Completed NCT02399501
44 Autocrosslinked Hyaluronic Acid Gel in Prevention of Intrauterine Adhesions After Bipolar Radiofrequency Endometrial Ablation: a Randomised, Controlled and Double Blind Study Completed NCT01829451
45 A Randomized Clinical Trial to Assess the Efficacy of Intrauterine Balloon Compared to Intrauterine Contraceptive Device Plus Foley Catheter in the Therapy for Uterine Adhesion After Hysteroscopic Adhesiolysis Completed NCT02867202
46 Randomized, Controlled Trial to Assess the Efficacy of Human Menopausal Gonadotrophin Stimulation and Hormone Replacement Therapy for Endometrial Preparation Prior to Blastocyst Transfer in Moderate to Severe Intrauterine Adhesion Patients Completed NCT03578172 human menopausal gonadotrophin;hormone replacement therapy
47 Hysteroscopy Assisted Suction Curettage for Early Pregnancy Loss: Does it Reduce Retained Products of Conception and Postoperative Intrauterine Adhesions? Recruiting NCT04637373
48 Treatment of Intrauterine Adhesions and Its Distribution of Genital Tract Flora Recruiting NCT03731689 Intrauterine lavage therapy;Intrauterine gel-injection therapy
49 Human Amniotic Epithelial Stem Cell in Treatment of Refractory Severe Intrauterine Adhesion Recruiting NCT03381807 Early Phase 1
50 Assessment of Uterine Access, Uterine Patency and Intrauterine Adhesions (IUA) 3, 6 and 12 Months Following Endometrial Ablation: A Prospective Single-Center Observational Study Recruiting NCT04824430

Search NIH Clinical Center for Adhesions of Uterus

Genetic Tests for Adhesions of Uterus

Anatomical Context for Adhesions of Uterus

MalaCards organs/tissues related to Adhesions of Uterus:

40
Uterus, Cervix, Bone Marrow, Bone, Placenta

Publications for Adhesions of Uterus

Articles related to Adhesions of Uterus:

(show top 50) (show all 64)
# Title Authors PMID Year
1
Outcome of using vaginal misoprostol for treatment of retained products of conception after first trimester miscarriage: a retrospective cohort study. 61
32869658 2020
2
Conservatively treated endometrial intraepithelial neoplasia/cancer: Risk of intrauterine synechiae. 61
33022448 2020
3
Diagnostic and therapeutic options in recurrent implantation failure. 61
32266059 2020
4
The importance of pseudocapsule preservation during hysteroscopic myomectomy. 61
31585677 2019
5
Early Second-Look Hysteroscopy: Prevention and Treatment of Intrauterine Post-surgical Adhesions. 61
31475154 2019
6
Diagnostic significance of chronic endometritis macrotypes differentiation among women with reproductive losses. 61
29264986 2017
7
Hysteroscopic metroplasty for the septate uterus with diode laser: a pilot study. 61
27632410 2016
8
Ultrasound guidance during hysteroscopic myomectomy in G1 and G2 Submucous Myomas: for a safer one step surgery. 61
27267872 2016
9
[Uterine anomalies in women with recurrent pregnancy loss]. 61
26122902 2015
10
[Intrauterine synechiae after use of monopolar resectoscope]. 61
26285485 2015
11
Intrauterine synechiae after myomectomy; laparotomy versus laparoscopy: Non-randomized interventional trial. 61
26000007 2015
12
Role of hysteroscopy and endometrial biopsy in women with unexplained infertility. 61
23872980 2014
13
Does cold loop hysteroscopic myomectomy reduce intrauterine adhesions? A retrospective study. 61
24182410 2014
14
Risk of postpartum uterine synechiae following uterine compression suturing during postpartum haemorrhage. 61
23163583 2013
15
Ultrasound is the optimal choice for guidance in difficult hysteroscopy. 61
22173892 2012
16
Hysteroscopy after uterine fibroid embolization: evaluation of intrauterine findings in 127 patients. 61
22413922 2012
17
Reproduction after myomectomy: comparison of patients with and without second-look laparoscopy. 61
21745136 2012
18
Operative hysteroscopy in a Jamaican cohort. 61
22512221 2011
19
Concomitant NovaSure endometrial ablation and Essure tubal sterilization: a review of 100 cases. 61
21501541 2011
20
Fertility and pregnancy outcomes following conservative treatment for placenta accreta. 61
20833739 2010
21
Pregnancy after hysteroscopic endometrial ablation without endometrial preparation: a report of five cases and a literature review. 61
21056317 2010
22
[Surgical management of intrauterine adhesions: is benefice bigger than risk?]. 61
20728396 2010
23
[Hysteroscopic evaluation in patients with infertility]. 61
21180876 2010
24
AAGL practice report: practice guidelines for management of intrauterine synechiae. 61
20129325 2010
25
The management of intrauterine synechiae. 61
19550326 2009
26
Uterine rupture resulting from the pressure of an intrauterine balloon. 61
19761638 2009
27
Balloon fluoroscopy as treatment for intrauterine adhesions: a novel approach. 61
18793771 2008
28
Efficiency and pregnancy outcome of serial intrauterine device-guided hysteroscopic adhesiolysis of intrauterine synechiae. 61
18774563 2008
29
Intrauterine adhesions. 61
18756412 2008
30
The uterus and fertility. 61
18155200 2008
31
Radiofrequency global endometrial ablation followed by hysteroscopic sterilization. 61
17630170 2007
32
The evaluation of uterine cavity with saline infusion sonohysterography and hysteroscopy in infertile patients. 61
16891990 2006
33
Uterine devascularization and subsequent major intrauterine synechiae and ovarian failure. 61
15749510 2005
34
Intrapartum spontaneous uterine rupture following uncomplicated resectoscopic treatment of Asherman's syndrome. 61
15880989 2005
35
Vesicouterine fistula and blind vagina. 61
12718783 2003
36
Screening for uterine abnormalities by three-dimensional ultrasound improves perinatal outcome. 61
11933661 2002
37
Three-dimensional ultrasound for routine check-up in in vitro fertilization patients. 61
10962044 2000
38
TRANSVAGINAL SALINE INFUSION SONOHYSTEROGRAPHY: INITIAL RESULTS. 61
28790677 2000
39
Total corporal synechiae due to tuberculosis carry a very poor prognosis following hysteroscopic synechialysis. 61
10438408 1999
40
Transvaginal sonohysterographic evaluation of intrauterine adhesions. 61
10064410 1999
41
The assessment of uterine and ovarian perfusion in infertile patients. 61
9138958 1997
42
Three-dimensional saline contrast hysterosonography and surface rendering of uterine cavity pathology. 61
8916383 1996
43
Comparative Hysteroscopic Findings in Women with Primary and Secondary Infertility 61
9074081 1996
44
Comparison of Operative and Fertility Outcome Between Groups of Women with Intrauterine Adhesions after Adhesiolysis 61
9074216 1996
45
Intrauterine adhesions: hysteroscopic lysis and adjunctive methods. 61
8798308 1996
46
Endometrial carcinoma arising within extensive intrauterine synechiae. 61
7805969 1994
47
Magnetic resonance imaging of intrauterine synechiae. 61
8125415 1994
48
[Diagnostic and therapeutic value of hysteroscopy in intrauterine synechiae]. 61
1491769 1992
49
Ultrasonography's role in detection of intrauterine synechiae. 61
2206063 1990
50
[Hysterographic follow-up of the results of treating uterine synechiae with an intrauterine contraceptive pessary]. 61
2205118 1990

Variations for Adhesions of Uterus

Expression for Adhesions of Uterus

Search GEO for disease gene expression data for Adhesions of Uterus.

Pathways for Adhesions of Uterus

Pathways related to Adhesions of Uterus according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.28 POU5F1 KDM6A AMH

GO Terms for Adhesions of Uterus

Biological processes related to Adhesions of Uterus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 8.92 POU5F1 KDM6A CCN2 AMH

Sources for Adhesions of Uterus

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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