MCID: ADH001
MIFTS: 28

Adhesions of Uterus

Categories: Reproductive diseases

Aliases & Classifications for Adhesions of Uterus

MalaCards integrated aliases for Adhesions of Uterus:

Name: Adhesions of Uterus 12 15 73
Intrauterine Adhesions 12 73
Intrauterine Synechiae 12
Asherman Syndrome 73
Band of Uterus 12

Classifications:



External Ids:

Disease Ontology 12 DOID:13812
ICD10 33 N85.6

Summaries for Adhesions of Uterus

MalaCards based summary : Adhesions of Uterus, also known as intrauterine adhesions, is related to asherman's syndrome. An important gene associated with Adhesions of Uterus is ARHGAP29 (Rho GTPase Activating Protein 29). The drugs Dimenhydrinate and Hyaluronic acid have been mentioned in the context of this disorder. Affiliated tissues include uterus, bone and bone marrow, and related phenotype is digestive/alimentary.

Related Diseases for Adhesions of Uterus

Diseases related to Adhesions of Uterus via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 asherman's syndrome 11.1

Symptoms & Phenotypes for Adhesions of Uterus

MGI Mouse Phenotypes related to Adhesions of Uterus:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 8.92 ARHGAP29 CTGF HOXA10 POU5F1

Drugs & Therapeutics for Adhesions of Uterus

Drugs for Adhesions of Uterus (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 56)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dimenhydrinate Approved Phase 4 523-87-5 441281
2
Hyaluronic acid Approved, Vet_approved Phase 4,Phase 3,Not Applicable,Early Phase 1 9004-61-9 53477741
3 Adjuvants, Immunologic Phase 4,Not Applicable,Early Phase 1
4 Carboxymethylcellulose Sodium Phase 4
5 Pharmaceutical Solutions Phase 4,Not Applicable
6 Protective Agents Phase 4,Not Applicable,Early Phase 1
7 Viscosupplements Phase 4,Not Applicable,Early Phase 1
8
Mifepristone Approved, Investigational Phase 3 84371-65-3 55245
9
Misoprostol Approved Phase 3 59122-46-2 5282381
10 Antacids Phase 3
11 Anti-Ulcer Agents Phase 3
12 Contraceptive Agents Phase 3,Not Applicable
13 Contraceptives, Oral Phase 3
14 Contraceptives, Postcoital Phase 3
15 Gastrointestinal Agents Phase 3
16 Hormone Antagonists Phase 3,Phase 1,Phase 2,Not Applicable
17 Hormones Phase 3,Phase 1,Phase 2,Not Applicable
18 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3,Phase 1,Phase 2,Not Applicable
19 Luteolytic Agents Phase 3
20 Oxytocics Phase 3
21
Estradiol Approved, Investigational, Vet_approved Phase 1, Phase 2,Not Applicable 50-28-2 5757
22 Estradiol valerate Approved, Investigational, Vet_approved Phase 1, Phase 2,Not Applicable 979-32-8
23
Polyestradiol phosphate Approved Phase 1, Phase 2,Not Applicable 28014-46-2
24 Estradiol 17 beta-cypionate Phase 1, Phase 2,Not Applicable
25 Estradiol 3-benzoate Phase 1, Phase 2,Not Applicable
26 Estrogens Phase 1, Phase 2,Phase 2,Not Applicable
27 Progestins Phase 1, Phase 2,Not Applicable
28 Anesthetics Phase 2,Not Applicable
29 Anti-Bacterial Agents Phase 2
30 Antibiotics, Antitubercular Phase 2
31
Ethanol Approved Early Phase 1 64-17-5 702
32
Aspirin Approved, Vet_approved Not Applicable 50-78-2 2244
33
Progesterone Approved, Vet_approved Not Applicable 57-83-0 5994
34
Tetracaine Approved, Vet_approved Not Applicable 94-24-6 5411
35
Iodine Approved, Investigational Not Applicable 7553-56-2 807
36
Povidone Approved Not Applicable 9003-39-8
37
Povidone-iodine Approved Not Applicable 25655-41-8
38
Copper Approved, Investigational Not Applicable 7440-50-8 27099
39
Lenograstim Approved, Investigational Not Applicable 135968-09-1
40
Medroxyprogesterone acetate Approved, Investigational Not Applicable 71-58-9
41
Zaleplon Approved, Illicit, Investigational 151319-34-5 5719
42 Analgesics Not Applicable
43 Analgesics, Non-Narcotic Not Applicable
44 Anti-Inflammatory Agents Not Applicable
45 Anti-Inflammatory Agents, Non-Steroidal Not Applicable
46 Antipyretics Not Applicable
47 Antirheumatic Agents Not Applicable
48 Cyclooxygenase Inhibitors Not Applicable
49 Fibrinolytic Agents Not Applicable
50 Peripheral Nervous System Agents Not Applicable

Interventional clinical trials:

(show all 49)
# Name Status NCT ID Phase Drugs
1 Treatment of Infertility by Collagen Scaffold Loaded With Autologous Bone Marrow Stem Cells Unknown status NCT02204358 Phase 4
2 Seprafilm Slurry in the Prevention of Uterine Scarring in Patients Undergoing Hysteroscopic Myomectomy Unknown status NCT01632202 Phase 4
3 Safety of Leaving Cook Balloon Uterine Stent in Uterus for One Month Completed NCT01167296 Phase 4
4 Effectiveness of Hyaluronic Acid Gel in the Prevention of Intrauterine Adhesions After Second Trimester Abortion Not yet recruiting NCT02868437 Phase 4
5 Cervical Preparation for Surgical Abortion at 12-14 Weeks: a Prospective, Randomized, Evaluator-blinded, Multicenter, Controlled Comparison Between Mifepristone, Misoprostol and Their Combination Unknown status NCT01795599 Phase 3 Mifegyne ®;Gymiso®
6 Hyaluronic Acid and Uterine Synechiae Active, not recruiting NCT02248376 Phase 3 Gel
7 Comparison of Different Doses of Oestrogen Therapy for Preventing Intrauterine Adhesion Completed NCT02726971 Phase 1, Phase 2 Femoston
8 Platelet-rich Plasma (PRP) for Endometrial Regeneration and Repair Recruiting NCT02825849 Phase 2
9 Treatment of Severe Asherman Syndrome by Collagen Scaffold Loaded With Autologous Bone Marrow Mononuclear Cells Recruiting NCT02680366 Phase 2
10 the Safety/Efficacy of Umbilical Cord Mesenchymal Stem Cell Therapy for Patients With Healing Poor After Uterus Injury Not yet recruiting NCT03386708 Phase 2 Normal saline (NS)
11 Myomectomy During Cesarean Section Completed NCT03095014 Phase 1
12 Efficiency of Amnion Graft to Prevent Intrauterine Adhesions After Hysteroscopic Surgery Unknown status NCT02132104 Not Applicable Femoston
13 The Efficacy and Safety of the Dried Biological Amnion Graft in Patients With Intrauterine Adhesions Unknown status NCT02496052 Not Applicable estradiol valerate tablets+dydrogesterone Tablets
14 Efficiency of INTERCOAT (Oxiplex/AP Gel) in Preventing Intrauterine Adhesion Formation in Hysteroscopic Surgery Unknown status NCT01637974 Not Applicable INTERCOAT administration
15 Prevention of Intrauterine Adhesions After Hysteroscopic Metroplasty With Autocross-linked Hyaluronic Acid Gel Unknown status NCT02404454 Not Applicable
16 Safety Study of Use of Hyaluronic Acid Gel To Prevent Intrauterine Adhesions In Hysteroscopic Surgery Unknown status NCT01464528 Early Phase 1 Hyaluronan
17 The Efficacy of A New Crosslinked Hyaluronan Gel in Prevention of Intrauterine Adhesion Completed NCT03353909 Not Applicable
18 The Value of Using Platelet Rich Plasma After Hysteroscopic Lysis of Severe Intrauterine Adhesions Completed NCT03541746 Not Applicable
19 Role of Chronic Endometritis in Postoperative Recurrence of Severe Intrauterine Adhesions Completed NCT02744807
20 Effects of Aspirin on Uterine Endometrial Repair Severe Intrauterine Adhesion Completed NCT02744716 Not Applicable Aspirin
21 Efficacy and Safety of Crosslinked Hyaluronan Gel for Preventing Intrauterine Adhesion Completed NCT02220621 Not Applicable
22 Hyaluronic Acid Gel in Prevention of Intrauterine Adhesions After Endometrial Ablation Completed NCT01829451 Not Applicable
23 Efficiency of Intercoat (Oxiplex/AP Gel)in Decreasing Intrauterine Adhesions Completed NCT01377779 Not Applicable Oxiplex/AP gel;Normal Saline
24 Treatment of Infertility by Collagen Scaffold Loaded With Umbilical Cord Derived Mesenchyma Stem Cells Completed NCT02313415 Not Applicable
25 Intrauterine Adhesion Rate After Hysteroscopic Myomectomy and Application of HYALOBARRIER Gel Completed NCT01412489 Not Applicable
26 Impact of Mindfulness Based Stress Reduction on Anxiety, Depression and QOL in Women With Intrauterine Adhesion. Completed NCT02746679 Not Applicable
27 Reproductive Outcome Affected by Two Adjunctive Treatments in Patients With Severe Intrauterine Adhesions Completed NCT02708277 Not Applicable
28 Postoperative Analgesic Efficacy of Tetracaine Hydrochloride Gel Completed NCT02863679 Not Applicable Tetracaine hydrochloride gel
29 UACE Followed by Uterine Suction Curettage for the Treatment of Caesarean Scar Pregnancy Completed NCT02357095 Not Applicable
30 Sonohysterography , 3D Ultrasonography and Hysteroscopy in Assessment of Uterine Factor in Cases of Female Infertility Completed NCT02399501 Not Applicable
31 Comparing Intra Uterine Synechiae Occurence Using Bipolar Energy Compared With Monopolar Energy in Myoma Resection on Women Having Menorraghia and/or Infertility Recruiting NCT02661087 Not Applicable
32 Intrauterine Balloon Dilatation Therapy in the Prevention of Adhesion Formation After Hysteroscopic Myomectomy Recruiting NCT03169478 Not Applicable
33 Comparing the Efficacy of Two Methods in the Prevention of Adhesion Reformation After Hysteroscopic Adhesiolysis Recruiting NCT03346317 Not Applicable estradiol valerate tablets+dydrogesterone tablets
34 Comparing the Efficacy of Intrauterine Balloon and Intrauterine Contraceptive Device for the Therapy of Uterine Adhesion Recruiting NCT02867202 Not Applicable
35 Comparing the Efficacy of Two Methods for the Therapy of Uterine Adhesion Recruiting NCT03329898 Not Applicable estradiol valerate tablets;dydrogesterone Tablets
36 Intrauterine Balloon Therapy to Prevent the Recurrence of Intrauterine Adhesions Recruiting NCT03131596 Not Applicable
37 HMG Stimulation Versus HRT for Endometrial Preparation Prior to Blastocyst Transfer in Moderate to Severe IUA Patients Recruiting NCT03578172 Not Applicable human menopausal gonadotrophin;hormone replacement therapy
38 The Efficacy of Estrogen Therapy Against Adhesion Reformation After Hysteroscopic Adhesiolysis Recruiting NCT03351205 Not Applicable estradiol valerate tablets+dydrogesterone tablets
39 The Efficacy and Safety of Disposable Balloon Uterine Stent in Patients With Asherman Syndrome Recruiting NCT03330873 Not Applicable
40 The Efficacy of G-CSF Against Adhesion Reformation After Hysteroscopic Adhesiolysis Recruiting NCT02855632 Not Applicable G-CSF;Normal saline;hormone therapy
41 Immediate and Delayed Intrauterine Balloon in the Prevention of Adhesion Reformation After Hysteroscopic Adhesiolysis Recruiting NCT03171454 Not Applicable
42 Effect of Pelvic Floor Muscle Electrophysiologic Therapy on Enhanced Recovery After Gynecologic Surgery Recruiting NCT03524807 Not Applicable
43 Use of an Intra Uterine Balloon to Prevent Recurrent Adhesions (REpAIR) Recruiting NCT03446755 Not Applicable
44 The Hysteroscopic Morcellator (HM). Recruiting NCT01537822 Not Applicable
45 Evaluation of Uterine Patency Following Sonography-guided Transcervical Ablation of Fibroids Active, not recruiting NCT02844920
46 Human Amniotic Epithelial Cell in Treatment of Refractory Severe Intrauterine Adhesion Not yet recruiting NCT03381807 Early Phase 1
47 Foley Balloon Therapy for Preventing Post-operative Adhesion Following Transection of Uterine Septum Not yet recruiting NCT02617108 Not Applicable
48 ExAblate Treatment of Uterine Fibroids for Fertility Enhancement Terminated NCT00730886 Not Applicable
49 Development of a Bioabsorbable Medical Device for the Prevention of Postoperative Intra-uterine Adhesions. Withdrawn NCT02328742

Search NIH Clinical Center for Adhesions of Uterus

Genetic Tests for Adhesions of Uterus

Anatomical Context for Adhesions of Uterus

MalaCards organs/tissues related to Adhesions of Uterus:

41
Uterus, Bone, Bone Marrow

Publications for Adhesions of Uterus

Articles related to Adhesions of Uterus:

(show all 12)
# Title Authors Year
1
Expression of SOX2, NANOG and OCT4 in a mouse model of lipopolysaccharide-induced acute uterine injury and intrauterine adhesions. ( 28253866 )
2017
2
Prevalence and Impact of Chronic Endometritis in Patients With Intrauterine Adhesions: A Prospective Cohort Study. ( 27773811 )
2017
3
Role of Transforming Growth Factor-I^1 and Smads Signaling Pathway in Intrauterine Adhesion. ( 26997760 )
2016
4
The Overexpression of TGF-I^ and CCN2 in Intrauterine Adhesions Involves the NF-I_B Signaling Pathway. ( 26719893 )
2015
5
Hysteroscopic Procedure for Type I Myoma With Intrauterine Adhesions. ( 27678645 )
2015
6
Intercoat (Oxiplex/AP gel) for preventing intrauterine adhesions after operative hysteroscopy for suspected retained products of conception: double-blind, prospective, randomized pilot study. ( 23954387 )
2014
7
Molecular implication of ADAM-15 and -17 in intrauterine adhesions. ( 23910172 )
2013
8
A pilot study of Foley's catheter balloon for prevention of intrauterine adhesions following breach of uterine cavity in complex myoma surgery. ( 23580010 )
2013
9
Postoperative adhesiolysis therapy for intrauterine adhesions (Asherman's syndrome). ( 18571166 )
2008
10
Secondary amenorrhea with severe intrauterine adhesions and chronic uterine torsion after Cesarean section in a teenage girl. ( 9593609 )
1998
11
[Intrauterine adhesion and ovulatory disorder following induced abortion]. ( 1748421 )
1991
12
Treatment of minimal and moderate intrauterine adhesions (Asherman's syndrome). ( 4067948 )
1985

Variations for Adhesions of Uterus

Expression for Adhesions of Uterus

Search GEO for disease gene expression data for Adhesions of Uterus.

Pathways for Adhesions of Uterus

GO Terms for Adhesions of Uterus

Biological processes related to Adhesions of Uterus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 response to wounding GO:0009611 9.16 CTGF POU5F1
2 positive regulation of gene expression GO:0010628 9.13 CTGF KDM6A POU5F1
3 regulation of gene expression GO:0010468 8.8 HOXA10 KDM6A POU5F1

Molecular functions related to Adhesions of Uterus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 sequence-specific DNA binding GO:0043565 8.8 HOXA10 KDM6A POU5F1

Sources for Adhesions of Uterus

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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