MCID: ADH006
MIFTS: 30

Adhesive Otitis Media

Categories: Ear diseases

Aliases & Classifications for Adhesive Otitis Media

MalaCards integrated aliases for Adhesive Otitis Media:

Name: Adhesive Otitis Media 12 15
Adhesive Middle Ear Disease 71 32
Chronic Adhesive Otitis Media 12

Classifications:



External Ids:

Disease Ontology 12 DOID:11235
ICD9CM 34 385.1 385.10
SNOMED-CT 67 7699004
ICD10 32 H74.1
UMLS 71 C0155478

Summaries for Adhesive Otitis Media

Disease Ontology : 12 An auditory system disease that is characterized by a thin retracted ear drum becomes sucked into the middle-ear space and stuck (i.e., adherent) to the ossicles and other bones of the middle ear.

MalaCards based summary : Adhesive Otitis Media, also known as adhesive middle ear disease, is related to otitis media and cholesteatoma of middle ear. An important gene associated with Adhesive Otitis Media is FLNA (Filamin A), and among its related pathways/superpathways are Folate Metabolism and Transcriptional misregulation in cancer. Affiliated tissues include bone and testes, and related phenotype is cardiovascular system.

Wikipedia : 74 Tympanic membrane retraction describes a condition in which a part of the eardrum lies deeper within the... more...

Related Diseases for Adhesive Otitis Media

Diseases related to Adhesive Otitis Media via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 66)
# Related Disease Score Top Affiliating Genes
1 otitis media 30.4 RNASE3 MPO CCL11
2 cholesteatoma of middle ear 10.4
3 ataxia, combined cerebellar and peripheral, with hearing loss and diabetes mellitus 10.3
4 dacryocystitis 10.3 FLNA DCT
5 acute inflammation of lacrimal passage 10.3 FLNA DCT
6 otosclerosis 10.2
7 thrombophilia due to activated protein c resistance 10.2 PLAT F9
8 sensorineural hearing loss 10.1
9 neuritis 10.1
10 chronic maxillary sinusitis 10.0 RNASE3 MPO
11 maxillary sinusitis 10.0 RNASE3 MPO
12 thrombophlebitis 10.0 PLAT F7
13 vernal conjunctivitis 10.0 RNASE3 MPO
14 prothrombin deficiency 10.0 F9 F7
15 chronic rhinitis 10.0 RNASE3 MPO
16 acquired von willebrand syndrome 10.0 F9 F7
17 coronary thrombosis 10.0 PLAT F7
18 vitamin k deficiency bleeding 10.0 F9 F7
19 cleft palate, isolated 10.0
20 branchiootic syndrome 1 10.0
21 mastoiditis 10.0
22 hyperacusis 10.0
23 scabies 10.0 FLNA CCL11
24 hemarthrosis 10.0 F9 F7
25 hemophilia 10.0 F9 F7
26 henoch-schoenlein purpura 9.9 RNASE3 MPO
27 factor x deficiency 9.9 F9 F7
28 factor v deficiency 9.9 F9 F7
29 factor xiii deficiency 9.9 F9 F7
30 collagenous colitis 9.9 RNASE3 MPO
31 factor viii deficiency 9.9 F9 F7
32 hemophilia a 9.9 F9 F7
33 pulmonary embolism 9.9 PLAT MPO F9
34 acute frontal sinusitis 9.9 DCT CCL11
35 pulmonary artery disease 9.9 PLAT F7
36 factor xi deficiency 9.8 F9 F7
37 cardiac tamponade 9.8 PLAT F9 F7
38 disseminated intravascular coagulation 9.8 PLAT F9 F7
39 blepharoconjunctivitis 9.8 RNASE3 CCL11
40 pemphigoid gestationis 9.8 RNASE3 CCL11
41 vernal keratoconjunctivitis 9.8 RNASE3 CCL11
42 inherited blood coagulation disease 9.8 F9 F7
43 pollen allergy 9.8 RNASE3 MPO
44 intrinsic asthma 9.8 RNASE3 CCL11
45 thrombophilia 9.8 PLAT F9 F7
46 giant papillary conjunctivitis 9.8 RNASE3 CCL11
47 chronic conjunctivitis 9.8 RNASE3 CCL11
48 kimura disease 9.7 RNASE3 CCL11
49 chronic eosinophilic pneumonia 9.7 RNASE3 CCL11
50 eosinophilic gastroenteritis 9.7 RNASE3 CCL11

Graphical network of the top 20 diseases related to Adhesive Otitis Media:



Diseases related to Adhesive Otitis Media

Symptoms & Phenotypes for Adhesive Otitis Media

MGI Mouse Phenotypes related to Adhesive Otitis Media:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.17 ATM F7 F9 FGF2 FLNA MPO

Drugs & Therapeutics for Adhesive Otitis Media

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Comparison of Half-thickness Tragal Cartilage Graft to Temporalis Fascia Graft Completed NCT03817242

Search NIH Clinical Center for Adhesive Otitis Media

Genetic Tests for Adhesive Otitis Media

Anatomical Context for Adhesive Otitis Media

MalaCards organs/tissues related to Adhesive Otitis Media:

40
Bone, Testes

Publications for Adhesive Otitis Media

Articles related to Adhesive Otitis Media:

(show top 50) (show all 127)
# Title Authors PMID Year
1
Transcanal Endoscopic Tympanoplasty for Pediatric Patients Under 15 Years of Age With Chronic Otitis Media. 61
31370387 2020
2
Cochlear Implantation in Patients with Chronic Suppurative Otitis Media: Surgical Outcomes and a Management Algorithm. 61
32018243 2020
3
Prevalence of Otitis Media with Effusion in Children with Hearing Loss. 61
31750164 2019
4
Treatment of adhesive otitis media by tympanoplasty combined with fascia grafting catheterization. 61
31273447 2019
5
Cartilage tympanoplasty combined with eustachian tube balloon dilatation in the treatment of adhesive otitis media. 61
30485447 2019
6
[The application of cartilage in middle ear surgery]. 61
30550140 2018
7
Effect of esterified hyaluronic acid as middle ear packing in tympanoplasty for adhesive otitis media. 61
29073815 2018
8
Outcomes of type I tympanoplasty using a cartilage shield graft in patients with poor prognostic factors. 61
27955869 2017
9
Postoperative Mastoid Aeration Following Canal Wall Up Mastoidectomy according to Preoperative Middle Ear Disease: Analysis of Temporal Bone Computed Tomography Scans. 61
28942628 2017
10
Impact of pharyngofixation in cleft palate repair surgery on the development of chronic adhesive otitis media. 61
28325168 2017
11
Autologous human nasal epithelial cell sheet using temperature-responsive culture insert for transplantation after middle ear surgery. 61
25846100 2017
12
The effects of surgery type and different ossiculoplasty materials on the hearing results in cholesteatoma surgery. 61
27837423 2017
13
Presence of osteoclasts in middle ear cholesteatoma: a study of undecalcified bone sections. 61
27575923 2017
14
Middle ear mucosal regeneration by tissue-engineered cell sheet transplantation. 61
29302343 2017
15
Tympanoplasty in adhesive otitis media: A descriptive study. 61
27167089 2016
16
Middle ear mucosal regeneration with three-dimensionally tissue-engineered autologous middle ear cell sheets in rabbit model. 61
23894137 2016
17
[Cholesteatoma of the external and middle ear in the childhood]. 61
25909669 2015
18
[Hearing disorders in young subjects]. 61
24577027 2014
19
Alternative to canal wall-down mastoidectomy for sclerotic mastoid cavities: epitympanoplasty with mastoid obliteration. 61
24574423 2014
20
Is cartilage better than temporalis muscle fascia in type I tympanoplasty? Implications for current surgical practice. 61
23321796 2013
21
Outcomes of cochlear implantation in children with CHARGE syndrome. 61
24125186 2013
22
Improvement of eustachian tube function by tissue-engineered regeneration of mastoid air cells. 61
23086494 2013
23
A technique for concurrent procedure of mastoid obliteration and meatoplasty after canal wall down mastoidectomy. 61
22321811 2012
24
Radiologic analysis of high jugular bulb by computed tomography. 61
22722144 2012
25
Mastoid obliteration with silicone blocks after canal wall down mastoidectomy. 61
22468198 2012
26
[Transmeatal aerodynamical otoendoscopy for otitis media]. 61
23250522 2012
27
[Diagnosis and treatment of adhesive otitis media]. 61
21874685 2011
28
[Functional multispiral computed tomography of sound-transmitting structures in the middle ear]. 61
21720292 2011
29
Long-term middle-ear ventilation with subannular tubes. 61
20403228 2010
30
Cochlear implantation in patients with chronic otitis media. 61
20189327 2010
31
[Tragus cartilage tympanoplasty for treatment of adhesive otitis media]. 61
20584683 2010
32
New morphometric findings in adhesive otitis media: petroclival angle and eustachian tube-tympanic cavity ventilation angle. 61
19427144 2010
33
[Cartilage palisade tympanoplasty for adhesive otitis media]. 61
19610589 2009
34
Mastoid obliteration using calcium phosphate bone paste with an artificial dermis soaked with basic fibroblast growth factor: preliminary clinical report. 61
18485642 2009
35
Cochlear implantation in atelectasis and chronic otitis media: long-term follow-up. 61
18520585 2008
36
Eustachian tube function and the middle ear. 61
17097443 2006
37
Dehiscent high jugular bulb: a pitfall in middle ear surgery. 61
16788425 2006
38
The role of multifrequency tympanometry in otitis media. 61
16532097 2006
39
Practical use of MESNA in atelectatic ears and adhesive otitis media. 61
16479146 2006
40
[Clinical manifestation of attic retraction pocket]. 61
16320713 2005
41
Regeneration of mastoid air cells in clinical applications by in situ tissue engineering. 61
15689745 2005
42
[Computed tomography of the temporal bone in diagnosis of adhesive otitis media]. 61
16025931 2005
43
Management of hemorrhagic high jugular bulb with adhesive otitis media in an only hearing ear: transcatheter endovascular embolization using detachable coils. 61
15633900 2004
44
[Potentialities of temporal bone computed tomography in the identification of causes of hypoacusis of postinflammatory genesis]. 61
15626228 2004
45
Körner's septum (petrosquamosal lamina) and chronic ear disease. 61
14586561 2004
46
[Operative therapy of the adhesive otitis media]. 61
15127568 2004
47
Tympanostomy preceding tympanoplasty: could it be a new approach for the management of adhesive otitis media. 61
14967090 2003
48
[A method for preventing recurrent scarring of the tympatic cavity in surgical treatment of patients with suppurative otitis media]. 61
14605663 2003
49
Gross dehiscence of the bone covering the facial nerve in the light of otological surgery. 61
12437834 2002
50
[A rare case of the high jugular bulb associated with only hearing ear]. 61
12235884 2002

Variations for Adhesive Otitis Media

Expression for Adhesive Otitis Media

Search GEO for disease gene expression data for Adhesive Otitis Media.

Pathways for Adhesive Otitis Media

GO Terms for Adhesive Otitis Media

Cellular components related to Adhesive Otitis Media according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 collagen-containing extracellular matrix GO:0062023 9.56 PLAT LGALS9 F9 F7
2 extracellular space GO:0005615 9.56 RNASE3 PLAT MPO LGALS9 FGF2 F9
3 azurophil granule lumen GO:0035578 9.33 TUBB RNASE3 MPO
4 extracellular region GO:0005576 9.32 TUBB RNASE3 PLAT MPO LGALS9 FLNA

Biological processes related to Adhesive Otitis Media according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.5 LGALS9 FGF2 CCL11
2 blood coagulation GO:0007596 9.43 PLAT F9 F7
3 ERK1 and ERK2 cascade GO:0070371 9.16 LGALS9 CCL11
4 response to hypoxia GO:0001666 9.13 PLAT F7 ATM
5 chemotaxis GO:0006935 8.8 LGALS9 FGF2 CCL11

Molecular functions related to Adhesive Otitis Media according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 serine-type endopeptidase activity GO:0004252 9.13 PLAT F9 F7
2 serine-type peptidase activity GO:0008236 8.8 PLAT F9 F7

Sources for Adhesive Otitis Media

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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