MCID: ADS001
MIFTS: 29

Adiaspiromycosis

Categories: Infectious diseases, Respiratory diseases, Skin diseases

Aliases & Classifications for Adiaspiromycosis

MalaCards integrated aliases for Adiaspiromycosis:

Name: Adiaspiromycosis 12 15 71

Classifications:



External Ids:

Disease Ontology 12 DOID:0050072
UMLS 71 C0259737

Summaries for Adiaspiromycosis

Disease Ontology : 12 A primary systemic mycosis that is a fungal infection located in lungs, or located in skin, which results in disseminated granulomatous pulmonary process and cutaneous infection in rodents, small wild mammals and humans, has material basis in Chrysosporium parvum or Emmonsia crescens.

MalaCards based summary : Adiaspiromycosis is related to blastomycosis and tinea manuum. An important gene associated with Adiaspiromycosis is KCNB1 (Potassium Voltage-Gated Channel Subfamily B Member 1), and among its related pathways/superpathways are ATP/ITP metabolism and Transcription Ligand-dependent activation of the ESR1/SP pathway. Affiliated tissues include lungs, skin and liver, and related phenotypes are Decreased viability and Decreased viability

Related Diseases for Adiaspiromycosis

Diseases related to Adiaspiromycosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 67)
# Related Disease Score Top Affiliating Genes
1 blastomycosis 30.2 KCNB1 CD4
2 tinea manuum 10.3 SQLE RPL10
3 tinea capitis 10.3 SQLE CD4
4 sporotrichosis 10.3 KCNB1 CD4
5 tinea barbae 10.2 SQLE RPL10
6 dermatophytosis 10.2 SQLE CD4
7 tungiasis 10.1 RRM1 CD4
8 retinitis pigmentosa 46 10.1 FBN1 CD4
9 actinomycosis 10.1 PAICS CD4 ACTB
10 autoimmune atherosclerosis 10.1 HSPD1 CD4
11 bacillary angiomatosis 10.1 HSPD1 CD4
12 opportunistic bacterial infectious disease 10.1 HSPD1 CD4
13 nocardiosis 10.1 HSPD1 CD4
14 chancroid 10.1 HSPD1 CD4
15 glanders 10.1 HSPD1 CD4
16 cat-scratch disease 10.1 HSPD1 CD4
17 respiratory failure 10.1
18 miliary tuberculosis 10.1
19 tenosynovitis 10.1 HSPD1 CD4
20 cervical adenitis 10.1 HSPD1 CD4
21 bartonellosis 10.1 HSPD1 CD4
22 orbital disease 10.1 FBN1 CD4
23 whipple disease 10.0 HSPD1 CD4
24 salpingitis 10.0 HSPD1 CD4
25 mucormycosis 10.0 PPIG CD4
26 hypotrichosis 2 10.0 PPIG CD4 ACTB
27 immune deficiency disease 10.0
28 histoplasmosis 10.0
29 hypotrichosis 1 10.0 PPIG CD4 ACTB
30 chlamydia pneumonia 10.0 HSPD1 CD4
31 smarca4-deficient sarcoma of thorax 9.9 SMARCA4 SMARCA2
32 tick infestation 9.9 HSPD1 CD4
33 basan syndrome 9.9 SMARCA4 SMARCA2
34 juvenile type testicular granulosa cell tumor 9.9 SMARCA4 SMARCA2
35 testicular granulosa cell tumor 9.9 SMARCA4 SMARCA2
36 inclusion body myopathy with early-onset paget disease of bone with or without frontotemporal dementia 2 9.9 HSPD1 CD4
37 developmental and epileptic encephalopathy 14 9.8 SMARCA4 SMARCA2
38 mesothelioma, malignant 9.8
39 sarcoidosis 1 9.8
40 aspergillosis 9.8
41 osteomyelitis 9.8
42 asbestosis 9.8
43 silicosis 9.8
44 anthracosis 9.8
45 siderosis 9.8
46 acute conjunctivitis 9.8
47 uveitis 9.8
48 fungal infectious disease 9.8
49 constipation 9.8
50 benign mesothelioma 9.8

Graphical network of the top 20 diseases related to Adiaspiromycosis:



Diseases related to Adiaspiromycosis

Symptoms & Phenotypes for Adiaspiromycosis

GenomeRNAi Phenotypes related to Adiaspiromycosis according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00249-S 9.58 KCNB1 PAICS POLR3G RPL10 RRM1 SH3BP5
2 Decreased viability GR00342-S-2 9.58 CD4
3 Decreased viability GR00381-A-1 9.58 ACTB RPL10 RRM1
4 Decreased viability GR00386-A-1 9.58 HPD RPL10 RRM1 TET1
5 Decreased viability GR00402-S-2 9.58 ACTB FBN1 POLR3C RRM1

MGI Mouse Phenotypes related to Adiaspiromycosis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 embryo MP:0005380 9.28 ACTB FBN1 HSPD1 PAICS POLR3G RRM1

Drugs & Therapeutics for Adiaspiromycosis

Search Clinical Trials , NIH Clinical Center for Adiaspiromycosis

Genetic Tests for Adiaspiromycosis

Anatomical Context for Adiaspiromycosis

The Foundational Model of Anatomy Ontology organs/tissues related to Adiaspiromycosis:

19
Lungs, Skin

MalaCards organs/tissues related to Adiaspiromycosis:

40
Liver, Skin

Publications for Adiaspiromycosis

Articles related to Adiaspiromycosis:

(show top 50) (show all 156)
# Title Authors PMID Year
1
Pulmonary adiaspiromycosis in armadillos killed by motor vehicle collisions in Brazil. 61
33432031 2021
2
Endemic mycoses: epidemiology and diagnostic strategies. 61
32620065 2020
3
Adiaspore development and morphological characteristics in a mouse adiaspiromycosis model. 61
32933583 2020
4
Intraspecific Diversity and Taxonomy of Emmonsia crescens. 61
32710392 2020
5
Causes of Mortality and Lesions Observed Post mortem in European Moles (Talpa europaea) in Cornwall, South-west England. 61
30898293 2019
6
Adiaspiromycosis in a wild European rabbit, and a review of the literature. 61
29717642 2018
7
Pulmonary adiaspiromycosis in critically endangered northern hairy-nosed wombats (Lasiorhinus krefftii). 61
29076222 2017
8
Pulmonary adiaspiromycosis in the Eurasian beaver (Castor fiber) inhabiting Poland. 61
29166284 2017
9
First detection of adiaspiromycosis in the lungs of a deer. 61
25787928 2015
10
Invasive pulmonary infection caused by Chrysosporium articulatum: the first case report. 61
25366105 2015
11
First description of adiaspiromycosis in an Eurasian otter (Lutra lutra) in Italy. 61
25273962 2014
12
Causes of mortality and pathological lesions observed post-mortem in red squirrels (Sciurus vulgaris) in Great Britain. 61
24238087 2013
13
A dimorphic fungus causing disseminated infection in South Africa. 61
24106934 2013
14
Disseminated pulmonary adiaspiromycosis in a crested porcupine (Hystrix cristata Linnaeus, 1758). 61
22493137 2012
15
Adiaspiromycosis causing respiratory failure and a review of human infections due to Emmonsia and Chrysosporium spp. 61
22259200 2012
16
Adiaspiromycosis of an Apodemus agrarius captured wild rodent in Korea. 61
22474477 2012
17
Disseminated adiaspiromycosis: case report of a liver transplant patient with human immunodeficiency infection, and literature review. 61
21323828 2011
18
[Pulmonary adiaspiromycosis treated without antifungal drugs]. 61
20305978 2010
19
Adiaspiromycosis due to Emmonsia crescens is widespread in native British mammals. 61
19533414 2009
20
Adiaspiromycosis mimicking widespread malignancy in a patient with pulmonary adenocarcinoma. 61
19734484 2009
21
Molecular diagnosis of disseminated adiaspiromycosis due to Emmonsia crescens. 61
19244459 2009
22
Acute conjunctivitis with episcleritis and anterior uveitis linked to adiaspiromycosis and freshwater sponges, Amazon region, Brazil, 2005. 61
19331759 2009
23
Aleutian disease serology, protein electrophoresis, and pathology of the European mink (Mustela lutreola) from Navarra, Spain. 61
18816991 2008
24
Fine needle aspiration of pulmonary adiaspiromycosis: a case report. 61
17425208 2007
25
Pulmonary adiaspiromycosis in a European hedgehog (Erinaceus europaeus) in Portugal. 61
16501161 2006
26
Cutaneous adiaspiromycosis: a distinct dermatologic entity associated with Chrysosporium species. 61
15577766 2004
27
[Human adiaspiromycosis: cicatricial lesions in mediastinal lymph nodes]. 61
15094906 2004
28
Disseminated pulmonary adiaspiromycosis caused by Emmonsia crescens in a horse. 61
12462193 2002
29
[Pulmonary adiaspiromycosis: casual finding in a patient who died of yellow fever]. 61
11340501 2001
30
Pulmonary adiaspiromycosis: report of two cases. 61
11064585 2000
31
[Contribution to the morphologic diagnosis of lung adiaspiromycosis]. 61
11064587 2000
32
Fatal adiaspiromycosis in a wild Eurasian otter (Lutra lutra). 61
11014486 2000
33
Pulmonary adiaspiromycosis in a patient with acquired immunodeficiency syndrome. 61
10691202 1999
34
[Adiaspiromycosis, 2 cases of incidental finding]. 61
10617808 1999
35
Pulmonary adiaspiromycosis in raccoons (Procyon lotor) from Oregon. 61
12968748 1999
36
Adiaspiromycosis in a European beaver from Sweden. 61
10231764 1999
37
Molecular genetic variation in Emmonsia crescens and Emmonsia parva, etiologic agents of adiaspiromycosis, and their phylogenetic relationship to Blastomyces dermatitidis (Ajellomyces dermatitidis) and other systemic fungal pathogens. 61
9738044 1998
38
Acute pulmonary adiaspiromycosis. Report of three cases and a review of 16 other cases collected from the literature. 61
15538822 1997
39
[Human adiaspiromycosis. A report of a case treated with ketoconazole]. 61
9463198 1997
40
[Disseminated pulmonary adiaspiromycosis. A case report]. 61
9380900 1997
41
Pulmonary adiaspiromycosis in a two year old girl. 61
9059367 1997
42
Adiaspiromycosis in bullfrogs (Rana catesbeiana). 61
8953541 1996
43
Ajellomyces crescens sp. nov., taxonomy of Emmonsia spp., and relatedness with Blastomyces dermatitidis (teleomorph Ajellomyces dermatitidis). 61
8912163 1996
44
Adiaspiromycosis in suspected cases of pulmonary tuberculosis in the common brushtail possum (Trichosurus vulpecula). 61
16031725 1993
45
Adiaspiromycosis: an unusual fungal infection of the lung. Report of 11 cases. 61
8352373 1993
46
Disseminated adiaspiromycosis in a patient with AIDS. 61
8483061 1993
47
Fulminant disseminated pulmonary adiaspiromycosis in humans. 61
1539748 1992
48
[Pulmonary adiaspiromycosis]. 61
1766990 1991
49
Review of animal mycoses in Australia. 61
2233984 1990
50
[Human pulmonary adiaspiromycosis. A new case of disseminated form]. 61
2131496 1990

Variations for Adiaspiromycosis

Expression for Adiaspiromycosis

Search GEO for disease gene expression data for Adiaspiromycosis.

Pathways for Adiaspiromycosis

Pathways related to Adiaspiromycosis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.06 RRM1 POLR3G POLR3C
2
Show member pathways
10.64 SMARCA4 SMARCA2 ACTB

GO Terms for Adiaspiromycosis

Cellular components related to Adiaspiromycosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 SWI/SNF complex GO:0016514 9.26 SMARCA4 SMARCA2
2 RNA polymerase III complex GO:0005666 9.16 POLR3G POLR3C
3 nBAF complex GO:0071565 8.96 SMARCA4 SMARCA2
4 npBAF complex GO:0071564 8.62 SMARCA4 SMARCA2

Biological processes related to Adiaspiromycosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of transcription by RNA polymerase III GO:0006359 8.96 POLR3G POLR3C
2 ATP-dependent chromatin remodeling GO:0043044 8.8 SMARCA4 SMARCA2 ACTB

Molecular functions related to Adiaspiromycosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 Tat protein binding GO:0030957 8.96 SMARCA4 ACTB
2 hydrolase activity, acting on acid anhydrides GO:0016817 8.62 SMARCA4 SMARCA2

Sources for Adiaspiromycosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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