Adiaspiromycosis disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: ADS001 MIFTS: 30	Adiaspiromycosis Categories: Infectious diseases, Respiratory diseases, Skin diseases
Genes Tissues Related diseases Publications Pathways Expand all tables

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Aliases & Classifications for Adiaspiromycosis

MalaCards integrated aliases for Adiaspiromycosis:

Name: Adiaspiromycosis ¹² ¹⁵ ⁷⁰

Classifications:

MalaCards categories:
Global: Infectious diseases
Anatomical: Skin diseases Respiratory diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:0050072

UMLS ⁷⁰ C0259737

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Summaries for Adiaspiromycosis

Disease Ontology : ¹² A primary systemic mycosis that is a fungal infection located in lungs, or located in skin, which results in disseminated granulomatous pulmonary process and cutaneous infection in rodents, small wild mammals and humans, has material basis in Chrysosporium parvum or Emmonsia crescens.

MalaCards based summary : Adiaspiromycosis is related to blastomycosis and tinea manuum. An important gene associated with Adiaspiromycosis is KCNB1 (Potassium Voltage-Gated Channel Subfamily B Member 1), and among its related pathways/superpathways are ATP/ITP metabolism and Transcription Ligand-dependent activation of the ESR1/SP pathway. Affiliated tissues include lungs, skin and bone, and related phenotypes are Decreased viability and Decreased viability

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Related Diseases for Adiaspiromycosis

Diseases related to Adiaspiromycosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 70)

#	Related Disease	Score	Top Affiliating Genes
1	blastomycosis	30.2	KCNB1 CD4
2	tinea manuum	10.3	SQLE RPL10
3	tinea capitis	10.3	SQLE CD4
4	sporotrichosis	10.3	KCNB1 CD4
5	tinea barbae	10.2	SQLE RPL10
6	tungiasis	10.1	RRM1 CD4
7	retinitis pigmentosa 46	10.1	FBN1 CD4
8	actinomycosis	10.1	PAICS CD4 ACTB
9	autoimmune atherosclerosis	10.1	HSPD1 CD4
10	dermatophytosis	10.1	SQLE CD4
11	bacillary angiomatosis	10.1	HSPD1 CD4
12	opportunistic bacterial infectious disease	10.1	HSPD1 CD4
13	nocardiosis	10.1	HSPD1 CD4
14	chancroid	10.1	HSPD1 CD4
15	glanders	10.1	HSPD1 CD4
16	cat-scratch disease	10.1	HSPD1 CD4
17	tenosynovitis	10.1	HSPD1 CD4
18	respiratory failure	10.1
19	miliary tuberculosis	10.1
20	cervical adenitis	10.1	HSPD1 CD4
21	orbital disease	10.1	FBN1 CD4
22	bartonellosis	10.1	HSPD1 CD4
23	whipple disease	10.1	HSPD1 CD4
24	mucormycosis	10.0	PPIG CD4
25	salpingitis	10.0	HSPD1 CD4
26	chlamydia pneumonia	10.0	HSPD1 CD4
27	hypotrichosis 2	10.0	PPIG CD4 ACTB
28	hypotrichosis 1	10.0	PPIG CD4 ACTB
29	histoplasmosis	10.0
30	tick infestation	10.0	HSPD1 CD4
31	inclusion body myopathy with early-onset paget disease of bone with or without frontotemporal dementia 2	9.9	HSPD1 CD4
32	smarca4-deficient sarcoma of thorax	9.9	SMARCA4 SMARCA2
33	basan syndrome	9.9	SMARCA4 SMARCA2
34	juvenile type testicular granulosa cell tumor	9.9	SMARCA4 SMARCA2
35	testicular granulosa cell tumor	9.9	SMARCA4 SMARCA2
36	urethritis	9.9	HSPD1 CD4
37	developmental and epileptic encephalopathy 14	9.9	SMARCA4 SMARCA2
38	non-syndromic intellectual disability	9.8	SMARCA4 SMARCA2 KCNB1
39	mesothelioma, malignant	9.8
40	sarcoidosis 1	9.8
41	immune deficiency disease	9.8
42	aspergillosis	9.8
43	ifap syndrome 2	9.8
44	osteomyelitis	9.8
45	asbestosis	9.8
46	silicosis	9.8
47	anthracosis	9.8
48	siderosis	9.8
49	acute conjunctivitis	9.8
50	uveitis	9.8

Graphical network of the top 20 diseases related to Adiaspiromycosis:

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Symptoms & Phenotypes for Adiaspiromycosis

GenomeRNAi Phenotypes related to Adiaspiromycosis according to GeneCards Suite gene sharing:

²⁶

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Decreased viability	GR00249-S	9.58	KCNB1 PAICS POLR3G RPL10 RRM1 SH3BP5
2	Decreased viability	GR00342-S-2	9.58	CD4
3	Decreased viability	GR00381-A-1	9.58	ACTB RPL10 RRM1
4	Decreased viability	GR00386-A-1	9.58	HPD RPL10 RRM1 TET1
5	Decreased viability	GR00402-S-2	9.58	ACTB FBN1 POLR3C RRM1

MGI Mouse Phenotypes related to Adiaspiromycosis:

⁴⁶

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	embryo	MP:0005380	9.28	ACTB FBN1 HSPD1 PAICS POLR3G RRM1

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Drugs & Therapeutics for Adiaspiromycosis

Search Clinical Trials , NIH Clinical Center for Adiaspiromycosis

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Genetic Tests for Adiaspiromycosis

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Anatomical Context for Adiaspiromycosis

The Foundational Model of Anatomy Ontology organs/tissues related to Adiaspiromycosis:

¹⁹

Lungs, Skin

MalaCards organs/tissues related to Adiaspiromycosis:

⁴⁰

Bone, Lung, Skin

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Publications for Adiaspiromycosis

Articles related to Adiaspiromycosis:

(show top 50) (show all 156)

#	Title	Authors	PMID	Year
1	Pulmonary adiaspiromycosis in armadillos killed by motor vehicle collisions in Brazil. ⁶¹	Navas-Suarez PE...Catao-Dias JL	33432031	2021
2	Endemic mycoses: epidemiology and diagnostic strategies. ⁶¹	Tirado-Sanchez A...Bonifaz A	32620065	2020
3	Adiaspore development and morphological characteristics in a mouse adiaspiromycosis model. ⁶¹	Takeshige A...Toyotome T	32933583	2020
4	Intraspecific Diversity and Taxonomy of Emmonsia crescens. ⁶¹	Jiang Y...de Hoog GS	32710392	2020
5	Causes of Mortality and Lesions Observed Post mortem in European Moles (Talpa europaea) in Cornwall, South-west England. ⁶¹	Simpson VR...Dagleish MP	30898293	2019
6	Adiaspiromycosis in a wild European rabbit, and a review of the literature. ⁶¹	Hughes K...Borman AM	29717642	2018
7	Pulmonary adiaspiromycosis in critically endangered northern hairy-nosed wombats (Lasiorhinus krefftii). ⁶¹	Schaffer-White AB...Allavena RE	29076222	2017
8	Pulmonary adiaspiromycosis in the Eurasian beaver (Castor fiber) inhabiting Poland. ⁶¹	Dolka I...Klucinski W	29166284	2017
9	First detection of adiaspiromycosis in the lungs of a deer. ⁶¹	Matsuda K...Taniyama H	25787928	2015
10	Invasive pulmonary infection caused by Chrysosporium articulatum: the first case report. ⁶¹	Suankratay C...Chindamporn A	25366105	2015
11	First description of adiaspiromycosis in an Eurasian otter (Lutra lutra) in Italy. ⁶¹	Malatesta D...Della Salda L	25273962	2014
12	Causes of mortality and pathological lesions observed post-mortem in red squirrels (Sciurus vulgaris) in Great Britain. ⁶¹	Simpson VR...Everest DJ	24238087	2013
13	A dimorphic fungus causing disseminated infection in South Africa. ⁶¹	Kenyon C...Govender NP	24106934	2013
14	Disseminated pulmonary adiaspiromycosis in a crested porcupine (Hystrix cristata Linnaeus, 1758). ⁶¹	Morandi F...Sarli G	22493137	2012
15	Adiaspiromycosis causing respiratory failure and a review of human infections due to Emmonsia and Chrysosporium spp. ⁶¹	Anstead GM...Graybill JR	22259200	2012
16	Adiaspiromycosis of an Apodemus agrarius captured wild rodent in Korea. ⁶¹	Kim TH...Park JH	22474477	2012
17	Disseminated adiaspiromycosis: case report of a liver transplant patient with human immunodeficiency infection, and literature review. ⁶¹	Pelegrin I...Cabellos C	21323828	2011
18	[Pulmonary adiaspiromycosis treated without antifungal drugs]. ⁶¹	Silva RM...Cunha Junior W	20305978	2010
19	Adiaspiromycosis due to Emmonsia crescens is widespread in native British mammals. ⁶¹	Borman AM...Johnson EM	19533414	2009
20	Adiaspiromycosis mimicking widespread malignancy in a patient with pulmonary adenocarcinoma. ⁶¹	Denson JL...Borman AM	19734484	2009
21	Acute conjunctivitis with episcleritis and anterior uveitis linked to adiaspiromycosis and freshwater sponges, Amazon region, Brazil, 2005. ⁶¹	Mendes MO...Hatch DL	19331759	2009
22	Molecular diagnosis of disseminated adiaspiromycosis due to Emmonsia crescens. ⁶¹	Dot JM...Machouart M	19244459	2009
23	Aleutian disease serology, protein electrophoresis, and pathology of the European mink (Mustela lutreola) from Navarra, Spain. ⁶¹	Sanchez-Migallon Guzman D...Cena JC	18816991	2008
24	Fine needle aspiration of pulmonary adiaspiromycosis: a case report. ⁶¹	Sun Y...Wasserman PG	17425208	2007
25	Pulmonary adiaspiromycosis in a European hedgehog (Erinaceus europaeus) in Portugal. ⁶¹	Seixas F...Pires MA	16501161	2006
26	Cutaneous adiaspiromycosis: a distinct dermatologic entity associated with Chrysosporium species. ⁶¹	Stebbins WG...Cohen S	15577766	2004
27	[Human adiaspiromycosis: cicatricial lesions in mediastinal lymph nodes]. ⁶¹	Moraes MA...Gomes MI	15094906	2004
28	Disseminated pulmonary adiaspiromycosis caused by Emmonsia crescens in a horse. ⁶¹	Pusterla N...Magdesian KG	12462193	2002
29	[Pulmonary adiaspiromycosis: casual finding in a patient who died of yellow fever]. ⁶¹	Moraes MA...Vianna LM	11340501	2001
30	[Contribution to the morphologic diagnosis of lung adiaspiromycosis]. ⁶¹	dos Santos VM...Teixeira VP	11064587	2000
31	Pulmonary adiaspiromycosis: report of two cases. ⁶¹	dos Santos VM...Adad SJ	11064585	2000
32	Fatal adiaspiromycosis in a wild Eurasian otter (Lutra lutra). ⁶¹	Simpson VR...Gavier-Widen D	11014486	2000
33	Pulmonary adiaspiromycosis in a patient with acquired immunodeficiency syndrome. ⁶¹	Turner D...Yust I	10691202	1999
34	[Adiaspiromycosis, 2 cases of incidental finding]. ⁶¹	Thomas De Montpreville V...Dulmet E	10617808	1999
35	Pulmonary adiaspiromycosis in raccoons (Procyon lotor) from Oregon. ⁶¹	Hamir AN	12968748	1999
36	Adiaspiromycosis in a European beaver from Sweden. ⁶¹	Morner T...Mattsson R	10231764	1999
37	Molecular genetic variation in Emmonsia crescens and Emmonsia parva, etiologic agents of adiaspiromycosis, and their phylogenetic relationship to Blastomyces dermatitidis (Ajellomyces dermatitidis) and other systemic fungal pathogens. ⁶¹	Peterson SW...Sigler L	9738044	1998
38	Acute pulmonary adiaspiromycosis. Report of three cases and a review of 16 other cases collected from the literature. ⁶¹	de Almeida Barbosa A...Severo LC	15538822	1997
39	[Human adiaspiromycosis. A report of a case treated with ketoconazole]. ⁶¹	Martins RL...Moraes MA	9463198	1997
40	[Disseminated pulmonary adiaspiromycosis. A case report]. ⁶¹	dos Santos VM...Fatureto Mda C	9380900	1997
41	Pulmonary adiaspiromycosis in a two year old girl. ⁶¹	Nuorva K...Juhola M	9059367	1997
42	Adiaspiromycosis in bullfrogs (Rana catesbeiana). ⁶¹	Hill JE...Parnell PG	8953541	1996
43	Ajellomyces crescens sp. nov., taxonomy of Emmonsia spp., and relatedness with Blastomyces dermatitidis (teleomorph Ajellomyces dermatitidis). ⁶¹	Sigler L	8912163	1996
44	Adiaspiromycosis in suspected cases of pulmonary tuberculosis in the common brushtail possum (Trichosurus vulpecula). ⁶¹	Johnstone AC...Woodgyer A	16031725	1993
45	Adiaspiromycosis: an unusual fungal infection of the lung. Report of 11 cases. ⁶¹	England DM...Hochholzer L	8352373	1993
46	Disseminated adiaspiromycosis in a patient with AIDS. ⁶¹	Echavarria E...Restrepo A	8483061	1993
47	Fulminant disseminated pulmonary adiaspiromycosis in humans. ⁶¹	Peres LC...Soares FA	1539748	1992
48	[Pulmonary adiaspiromycosis]. ⁶¹	Eri Z...Pavlovic S	1766990	1991
49	Review of animal mycoses in Australia. ⁶¹	Connole MD	2233984	1990
50	[Human pulmonary adiaspiromycosis. A new case of disseminated form]. ⁶¹	Moraes MA...Raick AN	2131496	1990

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Genes for Adiaspiromycosis

Genes related to Adiaspiromycosis (0 elite genes):

(show all 19)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	KCNB1	Potassium Voltage-Gated Channel Subfamily B Member 1	Protein Coding	6.18	DISEASES inferred ¹⁵
2	POLR3G	RNA Polymerase III Subunit G	Protein Coding	5.8	DISEASES inferred ¹⁵
3	POLR3C	RNA Polymerase III Subunit C	Protein Coding	5.75	DISEASES inferred ¹⁵
4	RPL10	Ribosomal Protein L10	Protein Coding	5.73	DISEASES inferred ¹⁵
5	HPD	4-Hydroxyphenylpyruvate Dioxygenase	Protein Coding	5.1	DISEASES inferred ¹⁵
6	SH3BP5	SH3 Domain Binding Protein 5	Protein Coding	4.99	DISEASES inferred ¹⁵
7	CD4	CD4 Molecule	Protein Coding	4.91	DISEASES inferred ¹⁵
8	CCL16	C-C Motif Chemokine Ligand 16	Protein Coding	4.82	DISEASES inferred ¹⁵
9	SQLE	Squalene Epoxidase	Protein Coding	4.66	DISEASES inferred ¹⁵
10	PAICS	Phosphoribosylaminoimidazole Carboxylase And Phosphoribosylaminoimidazolesuccinocarboxamide Synthase	Protein Coding	4.61	DISEASES inferred ¹⁵
11	ACTB	Actin Beta	Protein Coding	4.47	DISEASES inferred ¹⁵
12	ZNF569	Zinc Finger Protein 569	Protein Coding	4.38	DISEASES inferred ¹⁵
13	SMARCA2	SWI/SNF Related, Matrix Associated, Actin Dependent Regulator Of Chromatin, Subfamily A, Member 2	Protein Coding	4.08	DISEASES inferred ¹⁵
14	TET1	Tet Methylcytosine Dioxygenase 1	Protein Coding	3.99	DISEASES inferred ¹⁵
15	RRM1	Ribonucleotide Reductase Catalytic Subunit M1	Protein Coding	3.93	DISEASES inferred ¹⁵
16	FBN1	Fibrillin 1	Protein Coding	3.78	DISEASES inferred ¹⁵
17	HSPD1	Heat Shock Protein Family D (Hsp60) Member 1	Protein Coding	3.71	DISEASES inferred ¹⁵
18	SMARCA4	SWI/SNF Related, Matrix Associated, Actin Dependent Regulator Of Chromatin, Subfamily A, Member 4	Protein Coding	3.58	DISEASES inferred ¹⁵
19	PPIG	Peptidylprolyl Isomerase G	Protein Coding	3.29	DISEASES inferred ¹⁵

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Variations for Adiaspiromycosis

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Expression for Adiaspiromycosis

Search GEO for disease gene expression data for Adiaspiromycosis.

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Pathways for Adiaspiromycosis

Pathways related to Adiaspiromycosis according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	ATP/ITP metabolism ²³	11.06	RRM1 POLR3G POLR3C
2	Transcription Ligand-dependent activation of the ESR1/SP pathway ²³ Show member pathways Development Ligand-dependent activation of the ESR1/AP-1 pathway ²³	10.64	SMARCA4 SMARCA2 ACTB

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GO Terms for Adiaspiromycosis

Cellular components related to Adiaspiromycosis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	SWI/SNF complex	GO:0016514	9.26	SMARCA4 SMARCA2
2	RNA polymerase III complex	GO:0005666	9.16	POLR3G POLR3C
3	nBAF complex	GO:0071565	8.96	SMARCA4 SMARCA2
4	npBAF complex	GO:0071564	8.62	SMARCA4 SMARCA2

Biological processes related to Adiaspiromycosis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	positive regulation of T cell activation	GO:0050870	9.16	HSPD1 CD4
2	regulation of transcription by RNA polymerase III	GO:0006359	8.96	POLR3G POLR3C
3	ATP-dependent chromatin remodeling	GO:0043044	8.8	SMARCA4 SMARCA2 ACTB

Molecular functions related to Adiaspiromycosis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	Tat protein binding	GO:0030957	8.96	SMARCA4 ACTB
2	hydrolase activity, acting on acid anhydrides	GO:0016817	8.62	SMARCA4 SMARCA2

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