MCID: ADJ001
MIFTS: 36

Adjustment Disorder

Categories: Mental diseases

Aliases & Classifications for Adjustment Disorder

MalaCards integrated aliases for Adjustment Disorder:

Name: Adjustment Disorder 12 15
Adjustment Disorders 56 74
Adjustment Reaction 12 74
Adjustment Disease 12

Classifications:



External Ids:

Disease Ontology 12 DOID:507
ICD9CM 36 309 309.9
SNOMED-CT 69 17226007 63608001
ICD10 34 F43.2

Summaries for Adjustment Disorder

Disease Ontology : 12 A disease of mental health that is an abnormal and excessive emotional and behavioral reaction to a life stress that develops within 3 months of a life stress, and which is stronger or greater than what would be expected for the type of event that occurred.

MalaCards based summary : Adjustment Disorder, also known as adjustment disorders, is related to neurotic disorder and post-traumatic stress disorder. An important gene associated with Adjustment Disorder is GAL (Galanin And GMAP Prepropeptide). The drugs Risperidone and Dopamine have been mentioned in the context of this disorder. Affiliated tissues include brain, bone and breast.

Wikipedia : 77 An adjustment disorder (AD)—sometimes called exogenous, reactive, or situational depression—occurs when... more...

Related Diseases for Adjustment Disorder

Graphical network of the top 20 diseases related to Adjustment Disorder:



Diseases related to Adjustment Disorder

Symptoms & Phenotypes for Adjustment Disorder

Drugs & Therapeutics for Adjustment Disorder

Drugs for Adjustment Disorder (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 23)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Risperidone Approved, Investigational Phase 3 106266-06-2 5073
2
Dopamine Approved Phase 3 62-31-7, 51-61-6 681
3
Propranolol Approved, Investigational Phase 2, Phase 3 525-66-6 4946
4 Psychotropic Drugs Phase 3,Not Applicable
5 Central Nervous System Depressants Phase 3
6 Serotonin Antagonists Phase 3
7 Neurotransmitter Agents Phase 3,Phase 2
8 Tranquilizing Agents Phase 3
9 Dopamine Agents Phase 3
10 Antipsychotic Agents Phase 3
11 Serotonin Agents Phase 3
12 Dopamine Antagonists Phase 3
13 Adrenergic Agents Phase 2, Phase 3
14 Adrenergic Antagonists Phase 2, Phase 3
15 Anti-Arrhythmia Agents Phase 2, Phase 3
16 Antihypertensive Agents Phase 2, Phase 3
17 Adrenergic beta-Antagonists Phase 2, Phase 3
18 Vasodilator Agents Phase 2, Phase 3
19
Serotonin Investigational, Nutraceutical Phase 3 50-67-9 5202
20 Pharmaceutical Solutions Phase 1,Not Applicable
21
Nicotine Approved Not Applicable 54-11-5 89594 942
22
Benzocaine Approved, Investigational Not Applicable 1994-09-7, 94-09-7 2337
23
tannic acid Approved Not Applicable 1401-55-4

Interventional clinical trials:

(show all 45)
# Name Status NCT ID Phase Drugs
1 Study to Determine Whether There Are Any Cognitive or Motor Effects From Taking the Medicine Risperidone. Completed NCT00399698 Phase 3 Risperdal
2 The Trauma of Betrayal: Treating Adjustment Disorder With Reconsolidation Blockade Under Propranolol Recruiting NCT03151681 Phase 2, Phase 3 Propranolol Pill
3 Depression Prevention for Pregnant Women on Public Assistance Completed NCT00601757 Phase 2
4 The Efficacy of Parent Involvement in the Treatment of Adolescent Depression Completed NCT00883519 Phase 1, Phase 2
5 Group Interpersonal Psychotherapy for Depressed Adolescents in School-based Clinics Completed NCT00270244 Phase 2
6 Posttraumatic Stress Disorders in Police, Correctional Service Officers, and 911 Operators Recruiting NCT03152175 Phase 2 Propranolol Hydrochloride;Placebo
7 Improve: Integrating Emotion Focused Components Into Psychological Therapy Active, not recruiting NCT02822443 Phase 2
8 Psychological First Aid With Children in a High Risk Group - a Repeated Single Case Design Completed NCT01612104 Phase 1
9 Interpersonal Psychotherapy for Depressed Adolescents and Parents Completed NCT00619411 Phase 1
10 Does an Integrative Neuro-psychotherapy Program Foster the Adjustment in Depressed Stroke Patients? A Randomized Controlled Study. Terminated NCT01039857 Phase 1
11 Psychological Flexibility and Effectiveness of Psychotherapy Unknown status NCT02291068 Not Applicable
12 Internet-based Cognitive Behavior Therapy for Stress Disorders: a Randomized Trial Unknown status NCT02540317 Not Applicable
13 Neuropattern - Assessment of a Translational Diagnostic Tool for Depression, Adjustment- and Somatoform-disorders Unknown status NCT01062880 Not Applicable
14 Efficacy of Two Ways of Applying Homework Assignments in the Treatment of Adjustment Disorders Completed NCT02452411 Not Applicable
15 Validation of a Scale of Well-being at Work Completed NCT02905071 Not Applicable
16 Outcome Study of the ReDO Intervention for Women With Stress-related Disorders Completed NCT01234961 Not Applicable
17 Return to Work: Promoting Health and Productivity in Workers With Common Mental Disorders Completed NCT01805583 Not Applicable
18 MINDFUL-PC: Integrating Mindfulness Into the Patient-Centered Medical Home Completed NCT02972203 Not Applicable
19 Registry of Mastectomy for Breast Cancer Risk Reduction Completed NCT00555503
20 Psychiatric Day Hospital Treatment Completed NCT00153959 Not Applicable
21 Couples Coping With Multiple Chronic Medical Conditions Completed NCT01912157 Not Applicable
22 A Randomized Controlled Trial of PCIT-ED for Preschool Depression Completed NCT02076425 Not Applicable
23 Trends in Cohabitation Status, Academic Achievement and Socio-economic Indicators After Mild Traumatic Brain Injury Completed NCT03678077
24 Cognitive and Psychosocial Outcome After Mild Traumatic Brain Injury Completed NCT02161172
25 Multidimensional Assessment of Fatigue in Multiple Sclerosis- Observational Study - Ticino Completed NCT02082002
26 Neurobiological Effects of Work-related Adjustment Disorder Recruiting NCT03334045
27 Internet-based Self-help for Negative Life Events Recruiting NCT03379155 Not Applicable
28 Effectiveness of Two Stress Management Programs in Adaptation Disorder With Anxiety (ADA) Recruiting NCT02621775 Not Applicable
29 Efficacy of Two Internet Delivered Intervention Programs for Depression: Behavioral Activation vs Physical Activity Recruiting NCT02369393 Not Applicable
30 A Problem Solving Based Intervention for Facilitating Return-to-work Among People Suffering From Common Mental Disorders Recruiting NCT03346395 Not Applicable
31 Effects of Mindfulness Based Cognitive Therapy on Emotional Processing Recruiting NCT03358056 Not Applicable
32 Open Clinical Trial of CBT-based Multiprofessional Rehabilitation for Exhaustion Disorder Recruiting NCT03360136 Not Applicable
33 Reducing Distress and Depressive-symptoms in Rural Women Recruiting NCT03465813 Not Applicable
34 Integrating Mindfulness Into the Patient-Centered Medical Home (Phase 3) Recruiting NCT03609450 Not Applicable
35 Relevance of an Adapted and Supervised Physical Activity Program in Fibromyalgia Patients. The FIMOUV Study. Recruiting NCT03736733 Not Applicable
36 Development and Validation of an Online Treatment Program for Adjustment Disorders Active, not recruiting NCT02758418 Not Applicable
37 Integrated Mental Health Care and Vocational Rehabilitation to Individuals on Sick Leave Due to Stress Disorders Active, not recruiting NCT02885519 Not Applicable
38 Creating Meaning Following Cancer: An Intervention to Improve Existential and Global Quality of Life Active, not recruiting NCT01141933 Not Applicable
39 Return to Work Among Patients With Stress Related Mental Disorders - An Intervention in the Swedish Primary Care Active, not recruiting NCT03022760 Not Applicable
40 Integrating Mindfulness Into the Patient-Centered Medical Home (Phase 2) Active, not recruiting NCT03265600 Not Applicable
41 Stress and Mental Ill-health in the Workplace: Evaluation of an Intervention for the Prevention of Sick Leave Active, not recruiting NCT02563743 Not Applicable
42 Lower Urinary Tract Symptoms in Women and Adjustment Disorder Not yet recruiting NCT03444740
43 SelFIT: Internet-based Treatment for Adjustment Problems After an Accident Not yet recruiting NCT03785912 Not Applicable
44 Outpatient Nurse Monitoring Under the Prevention of Recurrent Suicidal Not yet recruiting NCT02721316 Not Applicable
45 Integrated Behavioral Health Innovations in Childhood Chronic Illness Care Delivery Systems Withdrawn NCT02740309 Not Applicable

Search NIH Clinical Center for Adjustment Disorder

Genetic Tests for Adjustment Disorder

Anatomical Context for Adjustment Disorder

MalaCards organs/tissues related to Adjustment Disorder:

42
Brain, Bone, Breast, Bone Marrow, Lung

Publications for Adjustment Disorder

Articles related to Adjustment Disorder:

(show top 50) (show all 226)
# Title Authors Year
1
An adaptive virtual reality system for the treatment of adjustment disorder and complicated grief: 1-year follow-up efficacy data. ( 30328216 )
2019
2
Prolonged grief disorder: Its co-occurrence with adjustment disorder and post-traumatic stress disorder in a bereaved Israeli general-population sample. ( 30797123 )
2019
3
Efficacy and feasibility of a humor training for people suffering from depression, anxiety, and adjustment disorder: a randomized controlled trial. ( 30894148 )
2019
4
Sleep Disturbance in Adjustment Disorder and Depressive Episode. ( 30917591 )
2019
5
The Role of Religion in Buffering the Impact of Stressful Life Events on Depressive Symptoms in Patients with Depressive Episodes or Adjustment Disorder. ( 30965549 )
2019
6
Revalidation of Adjustment Disorder-New Module-4 screening of adjustment disorder in a non-clinical sample: Psychometric reevaluation and correlates with other ICD-11 mental disorders. ( 30983131 )
2019
7
Relationship between induced abortion and the incidence of depression, anxiety disorder, adjustment disorder, and somatoform disorder in Germany. ( 31048110 )
2019
8
Reaction to Severe Stress and Adjustment Disorders After the September 2017 Earthquakes in a Psychiatric Emergency Department in Mexico City. ( 30602404 )
2019
9
Exploring the assessment of Adjustment Disorders: Differences between a general and a clinical sample. ( 30664406 )
2019
10
Adjustment disorder and type-specific cancer incidence: a Danish cohort study. ( 29688114 )
2018
11
Latent class analysis differentiation of adjustment disorder and demoralization, more severe depressive and anxiety disorders, and somatic symptoms in patients with cancer. ( 29761579 )
2018
12
Screening of adjustment disorder: Scale based on the ICD-11 and the Adjustment Disorder New Module. ( 29803077 )
2018
13
Efficacy of synchronous telepsychology interventions for people with anxiety, depression, posttraumatic stress disorder, and adjustment disorder: A rapid evidence assessment. ( 29809025 )
2018
14
An internet-based intervention for adjustment disorder (TAO): study protocol for a randomized controlled trial. ( 29855281 )
2018
15
A Systematic Review of Psychological and Pharmacological Treatments for Adjustment Disorder in Adults. ( 29958336 )
2018
16
Clinical features of a sample of inpatients with adjustment disorder referred to a consultation-liaison psychiatry service over 10 years. ( 30107936 )
2018
17
A comprehensive analysis of the factor structure of the Beck Depression Inventory-II in a sample of outpatients with adjustment disorder and depressive episode. ( 30115209 )
2018
18
Pharmacotherapy of adjustment disorder: A review. ( 30204560 )
2018
19
Adjustment disorder diagnosis: Improving clinical utility. ( 30204562 )
2018
20
New perspectives on adjustment disorder. ( 30204564 )
2018
21
Group Therapy for Patients with Adjustment Disorder in Primary Care. ( 30442217 )
2018
22
Prevalence and correlates of ICD-11 adjustment disorder: Findings from the Zurich Adjustment Disorder Study. ( 30487926 )
2018
23
How do adolescents with Adjustment Disorder cope with stressful situations? Relationship with suicidal risk. ( 30558955 )
2018
24
The role of therapist support on effectiveness of an internet-based modular self-help intervention for adjustment disorder: a randomized controlled trial. ( 28984157 )
2018
25
Is adjustment disorder unidimensional or multidimensional? Implications for ICD-11. ( 28990345 )
2018
26
Adjustment disorder: A diagnosis whose time has come. ( 29107817 )
2018
27
Internet-Based Self-Help Intervention for ICD-11 Adjustment Disorder: Preliminary Findings. ( 29124500 )
2018
28
Nail-extracting behaviour as an unusual manifestation of adjustment disorder, confused with onychotillomania. ( 29206306 )
2018
29
Evoked Death-Related Thoughts in the Aftermath of Terror Attack: The Associations Between Mortality Salience Effect and Adjustment Disorder. ( 29271826 )
2018
30
A Brief Measure of the International Classification of Diseases-11 Adjustment Disorder: Investigation of Psychometric Properties in an Adult Help-Seeking Sample. ( 29301130 )
2018
31
Altered autonomic reactivity in Korean military soldiers with adjustment disorder. ( 29353770 )
2018
32
A socio-interpersonal approach to adjustment disorder: the example of involuntary job loss. ( 29410777 )
2018
33
Adjustment disorder: current perspectives. ( 29416339 )
2018
34
An empirical assessment of adjustment disorder as proposed for ICD-11 in a general population sample of Israel. ( 29426030 )
2018
35
Economic evaluation of mindfulness group therapy for patients with depression, anxiety, stress and adjustment disorders compared with treatment as usual. ( 30468136 )
2018
36
Long-term improvements after mindfulness-based group therapy of depression, anxiety and stress and adjustment disorders: A randomized controlled trial. ( 29968371 )
2018
37
Insights Into Aspects Behind Internet-Related Disorders in Adolescents: The Interplay of Personality and Symptoms of Adjustment Disorders. ( 29174875 )
2018
38
Macrophage Migration Inhibitory Factor and microRNA-451a in Response to Mindfulness-based Therapy or Treatment as Usual in Patients with Depression, Anxiety, or Stress and Adjustment Disorders. ( 29373661 )
2018
39
The psychobiology of stress, depression, adjustment disorders and resilience. ( 30204561 )
2018
40
Psychotherapy of adjustment disorders: Current state and future directions. ( 30204563 )
2018
41
Psychopathological characteristics of adjustment disorder among outpatients with and without work related stress. ( 29916595 )
2017
42
Psychological defense mechanisms among individuals with SCI with adjustment disorder. ( 27077569 )
2017
43
Adjustment disorder: Empirical study of a new diagnostic concept for ICD-11 in the general population in Lithuania. ( 27837668 )
2017
44
Measuring the ICD-11 adjustment disorder concept: Validity and sensitivity to change of the Adjustment Disorder - New Module questionnaire in a clinical intervention study. ( 27862575 )
2017
45
Abnormal regional homogeneity and functional connectivity in adjustment disorder of new recruits: a resting-state fMRI study. ( 28144895 )
2017
46
Exploratory examination of the utility of demoralization as a diagnostic specifier for adjustment disorder and major depression. ( 28622810 )
2017
47
Adjustment disorder: Prevalence, sociodemographic risk factors, and its subtypes in outpatient psychiatric clinic. ( 28784404 )
2017
48
Prevalence and predictors of post-stroke mood disorders: A meta-analysis and meta-regression of depression, anxiety and adjustment disorder. ( 28807138 )
2017
49
Do previous experience and geographic proximity matter? Possible predictors for diagnosing Adjustment disorder vs. PTSD. ( 28951140 )
2017
50
Efficacy of Seren@ctif, a Computer-Based Stress Management Program for Patients With Adjustment Disorder With Anxiety: Protocol for a Controlled Trial. ( 28970192 )
2017

Variations for Adjustment Disorder

Expression for Adjustment Disorder

Search GEO for disease gene expression data for Adjustment Disorder.

Pathways for Adjustment Disorder

GO Terms for Adjustment Disorder

Cellular components related to Adjustment Disorder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 secretory granule GO:0030141 8.62 GAL TRH

Biological processes related to Adjustment Disorder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 neuron projection development GO:0031175 9.26 EHD1 NPY
2 neuropeptide signaling pathway GO:0007218 9.16 GAL NPY
3 regulation of signaling receptor activity GO:0010469 9.13 GAL NPY TRH
4 feeding behavior GO:0007631 8.62 GAL NPY

Molecular functions related to Adjustment Disorder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 neuropeptide hormone activity GO:0005184 8.96 GAL NPY
2 hormone activity GO:0005179 8.8 GAL NPY TRH

Sources for Adjustment Disorder

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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