MCID: ADJ001
MIFTS: 36

Adjustment Disorder

Categories: Mental diseases

Aliases & Classifications for Adjustment Disorder

MalaCards integrated aliases for Adjustment Disorder:

Name: Adjustment Disorder 12 15
Adjustment Disorders 55 73
Adjustment Reaction 12 73
Adjustment Disease 12

Classifications:



External Ids:

Disease Ontology 12 DOID:507
ICD9CM 35 309 309.9
ICD10 33 F43.2

Summaries for Adjustment Disorder

Disease Ontology : 12 A disease of mental health that is an abnormal and excessive emotional and behavioral reaction to a life stress that develops within 3 months of a life stress, and which is stronger or greater than what would be expected for the type of event that occurred.

MalaCards based summary : Adjustment Disorder, also known as adjustment disorders, is related to neurotic disorder and post-traumatic stress disorder. An important gene associated with Adjustment Disorder is GAL (Galanin And GMAP Prepropeptide). The drugs Dopamine and Risperidone have been mentioned in the context of this disorder. Affiliated tissues include brain, breast and bone.

Wikipedia : 76 An adjustment disorder (AD)—sometimes called exogenous, reactive, or situational depression—occurs when... more...

Related Diseases for Adjustment Disorder

Diseases related to Adjustment Disorder via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 16)
# Related Disease Score Top Affiliating Genes
1 neurotic disorder 11.6
2 post-traumatic stress disorder 10.4
3 depression 10.3
4 anxiety 10.1
5 major depressive disorder 9.8
6 status epilepticus 9.7 GAL NPY
7 alexithymia 9.7
8 mood disorder 9.7
9 neuronitis 9.7
10 conduct disorder 9.5
11 aging 9.5
12 myocardial infarction 9.5
13 acute myocardial infarction 9.5
14 diabetes mellitus 9.5
15 generalized anxiety disorder 9.5
16 personality disorder 9.5

Comorbidity relations with Adjustment Disorder via Phenotypic Disease Network (PDN):


Acute Cystitis Anxiety
Deficiency Anemia Dysthymic Disorder
Heart Disease Hypertension, Essential
Ischemic Heart Disease Major Depressive Disorder
Schizophreniform Disorder

Graphical network of the top 20 diseases related to Adjustment Disorder:



Diseases related to Adjustment Disorder

Symptoms & Phenotypes for Adjustment Disorder

Drugs & Therapeutics for Adjustment Disorder

Drugs for Adjustment Disorder (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 24)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dopamine Approved Phase 3 51-61-6, 62-31-7 681
2
Risperidone Approved, Investigational Phase 3 106266-06-2 5073
3
Propranolol Approved, Investigational Phase 2, Phase 3 525-66-6 4946
4 Psychotropic Drugs Phase 3,Not Applicable
5 Central Nervous System Depressants Phase 3
6 Serotonin Agents Phase 3
7 Serotonin Antagonists Phase 3
8 Neurotransmitter Agents Phase 3,Phase 2
9 Tranquilizing Agents Phase 3
10 Dopamine Agents Phase 3
11 Dopamine Antagonists Phase 3
12 Antipsychotic Agents Phase 3
13 Adrenergic Agents Phase 2, Phase 3
14 Adrenergic Antagonists Phase 2, Phase 3
15 Adrenergic beta-Antagonists Phase 2, Phase 3
16 Anti-Arrhythmia Agents Phase 2, Phase 3
17 Vasodilator Agents Phase 2, Phase 3
18 Antihypertensive Agents Phase 2, Phase 3
19
Serotonin Investigational, Nutraceutical Phase 3 50-67-9 5202
20 Pharmaceutical Solutions Phase 1,Not Applicable
21
Nicotine Approved Not Applicable 54-11-5 942 89594
22
Menthol Approved Not Applicable 2216-51-5 16666
23
Benzocaine Approved, Investigational Not Applicable 1994-09-7, 94-09-7 2337
24 tannic acid Approved, Nutraceutical Not Applicable

Interventional clinical trials:

(show all 41)
# Name Status NCT ID Phase Drugs
1 Study to Determine Whether There Are Any Cognitive or Motor Effects From Taking the Medicine Risperidone. Completed NCT00399698 Phase 3 Risperdal
2 The Trauma of Betrayal: Treating Adjustment Disorder With Reconsolidation Blockade Under Propranolol Active, not recruiting NCT03151681 Phase 2, Phase 3 Propranolol Pill
3 Depression Prevention for Pregnant Women on Public Assistance Completed NCT00601757 Phase 2
4 The Efficacy of Parent Involvement in the Treatment of Adolescent Depression Completed NCT00883519 Phase 1, Phase 2
5 Group Interpersonal Psychotherapy for Depressed Adolescents in School-based Clinics Completed NCT00270244 Phase 2
6 Improve: Integrating Emotion Focused Components Into Psychological Therapy Recruiting NCT02822443 Phase 2
7 Posttraumatic Stress Disorders in Police, Correctional Service Officers, and 911 Operators Recruiting NCT03152175 Phase 2 Propranolol Hydrochloride;Placebo
8 Psychological First Aid With Children in a High Risk Group - a Repeated Single Case Design Completed NCT01612104 Phase 1
9 Interpersonal Psychotherapy for Depressed Adolescents and Parents Completed NCT00619411 Phase 1
10 Does an Integrative Neuro-psychotherapy Program Foster the Adjustment in Depressed Stroke Patients? A Randomized Controlled Study. Terminated NCT01039857 Phase 1
11 Psychological Flexibility and Effectiveness of Psychotherapy Unknown status NCT02291068 Not Applicable
12 Neuropattern - Assessment of a Translational Diagnostic Tool for Depression, Adjustment- and Somatoform-disorders Unknown status NCT01062880 Not Applicable
13 Efficacy of Two Ways of Applying Homework Assignments in the Treatment of Adjustment Disorders Completed NCT02452411 Not Applicable
14 Outcome Study of the ReDO Intervention for Women With Stress-related Disorders Completed NCT01234961 Not Applicable
15 Return to Work: Promoting Health and Productivity in Workers With Common Mental Disorders Completed NCT01805583 Not Applicable
16 Registry of Mastectomy for Breast Cancer Risk Reduction Completed NCT00555503
17 Psychiatric Day Hospital Treatment Completed NCT00153959 Not Applicable
18 A Randomized Controlled Trial of PCIT-ED for Preschool Depression Completed NCT02076425 Not Applicable
19 Cognitive and Psychosocial Outcome After Mild Traumatic Brain Injury Completed NCT02161172
20 Neurobiological Effects of Work-related Adjustment Disorder Recruiting NCT03334045
21 Development and Validation of an Online Treatment Program for Adjustment Disorders Recruiting NCT02758418 Not Applicable
22 Internet-based Self-help for Negative Life Events Recruiting NCT03379155 Not Applicable
23 Integrated Mental Health Care and Vocational Rehabilitation to Individuals on Sick Leave Due to Stress Disorders Recruiting NCT02885519 Not Applicable
24 Effectiveness of Two Stress Management Programs in Adaptation Disorder With Anxiety (ADA) Recruiting NCT02621775 Not Applicable
25 Validation of a Scale of Well-being at Work Recruiting NCT02905071 Not Applicable
26 Efficacy of Two Internet Delivered Intervention Programs for Depression: Behavioral Activation vs Physical Activity Recruiting NCT02369393 Not Applicable
27 A Problem Solving Based Intervention for Facilitating Return-to-work Among People Suffering From Common Mental Disorders Recruiting NCT03346395 Not Applicable
28 Effects of Mindfulness Based Cognitive Therapy on Emotional Processing Recruiting NCT03358056 Not Applicable
29 Open Clinical Trial of CBT-based Multiprofessional Rehabilitation for Exhaustion Disorder Recruiting NCT03360136 Not Applicable
30 MINDFUL-PC: Integrating Mindfulness Into the Patient-Centered Medical Home Recruiting NCT03265600 Not Applicable
31 Reducing Distress and Depressive-symptoms in Rural Women Recruiting NCT03465813 Not Applicable
32 Multidimensional Assessment of Fatigue in Multiple Sclerosis- Observational Study - Ticino Recruiting NCT02082002
33 Internet-based Cognitive Behavior Therapy for Stress Disorders: a Randomized Trial Active, not recruiting NCT02540317 Not Applicable
34 Creating Meaning Following Cancer: An Intervention to Improve Existential and Global Quality of Life Active, not recruiting NCT01141933 Not Applicable
35 Return to Work Among Patients With Stress Related Mental Disorders - An Intervention in the Swedish Primary Care Active, not recruiting NCT03022760 Not Applicable
36 MINDFUL-PC: Integrating Mindfulness Into the Patient-Centered Medical Home Active, not recruiting NCT02972203 Not Applicable
37 Couples Coping With Multiple Chronic Medical Conditions Active, not recruiting NCT01912157 Not Applicable
38 Stress and Mental Ill-health in the Workplace: Evaluation of an Intervention for the Prevention of Sick Leave Active, not recruiting NCT02563743 Not Applicable
39 Lower Urinary Tract Symptoms in Women and Adjustment Disorder Not yet recruiting NCT03444740
40 Outpatient Nurse Monitoring Under the Prevention of Recurrent Suicidal Not yet recruiting NCT02721316 Not Applicable
41 Integrated Behavioral Health Innovations in Childhood Chronic Illness Care Delivery Systems Withdrawn NCT02740309 Not Applicable

Search NIH Clinical Center for Adjustment Disorder

Genetic Tests for Adjustment Disorder

Anatomical Context for Adjustment Disorder

MalaCards organs/tissues related to Adjustment Disorder:

41
Brain, Breast, Bone, Bone Marrow

Publications for Adjustment Disorder

Articles related to Adjustment Disorder:

(show top 50) (show all 135)
# Title Authors Year
1
Adjustment disorder and type-specific cancer incidence: a Danish cohort study. ( 29688114 )
2018
2
Adjustment disorder: A diagnosis whose time has come. ( 29107817 )
2018
3
An internet-based intervention for adjustment disorder (TAO): study protocol for a randomized controlled trial. ( 29855281 )
2018
4
Altered autonomic reactivity in Korean military soldiers with adjustment disorder. ( 29353770 )
2018
5
A Brief Measure of the International Classification of Diseases-11 Adjustment Disorder: Investigation of Psychometric Properties in an Adult Help-Seeking Sample. ( 29301130 )
2018
6
Latent class analysis differentiation of adjustment disorder and demoralization, more severe depressive and anxiety disorders, and somatic symptoms in patients with cancer. ( 29761579 )
2018
7
A Systematic Review of Psychological and Pharmacological Treatments for Adjustment Disorder in Adults. ( 29958336 )
2018
8
Screening of adjustment disorder: Scale based on the ICD-11 and the Adjustment Disorder New Module. ( 29803077 )
2018
9
An empirical assessment of adjustment disorder as proposed for ICD-11 in a general population sample of Israel. ( 29426030 )
2018
10
Efficacy of synchronous telepsychology interventions for people with anxiety, depression, posttraumatic stress disorder, and adjustment disorder: A rapid evidence assessment. ( 29809025 )
2018
11
Adjustment disorder: current perspectives. ( 29416339 )
2018
12
Evoked Death-Related Thoughts in the Aftermath of Terror Attack: The Associations Between Mortality Salience Effect and Adjustment Disorder. ( 29271826 )
2018
13
The role of therapist support on effectiveness of an internet-based modular self-help intervention for adjustment disorder: a randomized controlled trial. ( 28984157 )
2018
14
A socio-interpersonal approach to adjustment disorder: the example of involuntary job loss. ( 29410777 )
2018
15
Adjustment disorder: Prevalence, sociodemographic risk factors, and its subtypes in outpatient psychiatric clinic. ( 28784404 )
2017
16
A scoping review of ICD-11 adjustment disorder research. ( 29372011 )
2017
17
Internet-Based Self-Help Intervention for ICD-11 Adjustment Disorder: Preliminary Findings. ( 29124500 )
2017
18
Is adjustment disorder unidimensional or multidimensional? Implications for ICD-11. ( 28990345 )
2017
19
Do previous experience and geographic proximity matter? Possible predictors for diagnosing Adjustment disorder vs. PTSD. ( 28951140 )
2017
20
Psychopathological characteristics of adjustment disorder among outpatients with and without work related stress. ( 29916595 )
2017
21
Nail-extracting behaviour as an unusual manifestation of adjustment disorder, confused with onychotillomania. ( 29206306 )
2017
22
Exploratory examination of the utility of demoralization as a diagnostic specifier for adjustment disorder and major depression. ( 28622810 )
2017
23
Integrated mental health care and vocational rehabilitation to improve return to work rates for people on sick leave because of exhaustion disorder, adjustment disorder, and distress (the Danish IBBIS trial): study protocol for a randomized controlled trial. ( 29197404 )
2017
24
Efficacy of Seren@ctif, a Computer-Based Stress Management Program for Patients With Adjustment Disorder With Anxiety: Protocol for a Controlled Trial. ( 28970192 )
2017
25
Abnormal regional homogeneity and functional connectivity in adjustment disorder of new recruits: a resting-state fMRI study. ( 28144895 )
2017
26
Prevalence and predictors of post-stroke mood disorders: A meta-analysis and meta-regression of depression, anxiety and adjustment disorder. ( 28807138 )
2017
27
The Adjustment Disorder--New Module 20 as a Screening Instrument: Cluster Analysis and Cut-off Values. ( 27651082 )
2016
28
Self-help interventions for adjustment disorder problems: a randomized waiting-list controlled study in a sample of burglary victims. ( 27299909 )
2016
29
Measuring the ICD-11 adjustment disorder concept: Validity and sensitivity to change of the Adjustment Disorder - New Module questionnaire in a clinical intervention study. ( 27862575 )
2016
30
Adjustment disorder and risk of Parkinson's disease. ( 26756302 )
2016
31
Decreased medial frontal gyrus in patients with adjustment disorder. ( 26630395 )
2016
32
A longitudinal study on anxiety, depressive and adjustment disorder, suicide ideation and symptoms of emotional distress in patients with cancer undergoing radiotherapy. ( 27411747 )
2016
33
Adjustment disorder: Empirical study of a new diagnostic concept for ICD-11 in the general population in Lithuania. ( 27837668 )
2016
34
Psychological defense mechanisms among individuals with SCI with adjustment disorder. ( 27077569 )
2016
35
The bimodal P300 oddball component is decreased in patients with an adjustment disorder: An event-related potentials study. ( 27521621 )
2016
36
Demographic variables, clinical aspects, and medicolegal implications in a population of patients with adjustment disorder. ( 27099504 )
2016
37
Internet-based modular program BADI for adjustment disorder: protocol of a randomized controlled trial. ( 27456085 )
2016
38
A Longitudinal Study of Adjustment Disorder After Trauma Exposure. ( 27771970 )
2016
39
Adjustment Disorder as an Occupational Disease: Our Experience in Italy. ( 26772598 )
2016
40
Suicidal behaviours in adjustment disorder and depressive episode. ( 25553405 )
2015
41
Suicidal Tendency Among Adolescents With Adjustment Disorder. ( 26088824 )
2015
42
Validity of reaction to severe stress and adjustment disorder diagnoses in the Danish Psychiatric Central Research Registry. ( 25870515 )
2015
43
Adjustment Disorder in Pregnant Women: Prevalence and Correlates in a Northern Mexican City. ( 26346070 )
2015
44
Etifoxine versus alprazolam for the treatment of adjustment disorder with anxiety: a randomized controlled trial. ( 25620535 )
2015
45
STRESSORS, SYMPTOM PROFILE, AND PREDICTORS OF ADJUSTMENT DISORDER IN CANCER PATIENTS. RESULTS FROM AN EPIDEMIOLOGICAL STUDY WITH THE COMPOSITE INTERNATIONAL DIAGNOSTIC INTERVIEW, ADAPTATION FOR ONCOLOGY (CIDI-O). ( 26474266 )
2015
46
Subarachnoid hemorrhage misdiagnosed as adjustment disorder. ( 25806556 )
2015
47
Adjustment disorder as proposed for ICD-11: Dimensionality and symptom differentiation. ( 26272020 )
2015
48
Suicidal tendency in a sample of adolescent outpatients with adjustment disorder: gender differences. ( 24889338 )
2014
49
Development and validation of the Diagnostic Interview Adjustment Disorder (DIAD). ( 24478059 )
2014
50
Severe stress and adjustment disorder diagnoses in the population of denmark. ( 24948539 )
2014

Variations for Adjustment Disorder

Expression for Adjustment Disorder

Search GEO for disease gene expression data for Adjustment Disorder.

Pathways for Adjustment Disorder

GO Terms for Adjustment Disorder

Cellular components related to Adjustment Disorder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytoplasm GO:0005737 9.5 ANKS1A CPS1 GAL KIAA1217 NPY PRKCD
2 secretory granule GO:0030141 8.62 GAL TRH

Biological processes related to Adjustment Disorder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 neuropeptide signaling pathway GO:0007218 9.16 GAL NPY
2 feeding behavior GO:0007631 8.96 GAL NPY
3 regulation of signaling receptor activity GO:0010469 8.92 GAL NPY PRKCD TRH

Molecular functions related to Adjustment Disorder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 neuropeptide hormone activity GO:0005184 8.96 GAL NPY
2 hormone activity GO:0005179 8.8 GAL NPY TRH

Sources for Adjustment Disorder

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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