Adjustment Disorder

Categories: Mental diseases

Aliases & Classifications for Adjustment Disorder

MalaCards integrated aliases for Adjustment Disorder:

Name: Adjustment Disorder 12 15
Adjustment Disorders 54 71
Adjustment Reaction 12 71
Adjustment Disease 12


External Ids:

Disease Ontology 12 DOID:507
ICD9CM 34 309
UMLS 71 C0001546 C0040701

Summaries for Adjustment Disorder

Disease Ontology : 12 A disease of mental health that is an abnormal and excessive emotional and behavioral reaction to a life stress that develops within 3 months of a life stress, and which is stronger or greater than what would be expected for the type of event that occurred.

MalaCards based summary : Adjustment Disorder, also known as adjustment disorders, is related to neurotic disorder and post-traumatic stress disorder. An important gene associated with Adjustment Disorder is NPY (Neuropeptide Y). The drugs Dopamine and Risperidone have been mentioned in the context of this disorder. Affiliated tissues include eye, breast and brain, and related phenotypes are behavior/neurological and homeostasis/metabolism

Wikipedia : 74 An adjustment disorder (AjD) occurs when an individual has significant difficulty adjusting to or coping... more...

Related Diseases for Adjustment Disorder

Diseases related to Adjustment Disorder via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 115)
# Related Disease Score Top Affiliating Genes
1 neurotic disorder 33.2 SLC6A4 HTR2A FLNA BDNF
2 post-traumatic stress disorder 31.2 SLC6A4 NPY HTR2A BDNF
3 depression 30.7 SLC6A4 HTR2A BDNF
4 acute stress disorder 30.6 SLC6A4 CFI BDNF
5 mental depression 30.4 SLC6A4 SCLY HTR2A BDNF
6 personality disorder 30.4 SLC6A4 HTR2A BDNF
7 mood disorder 30.2 SLC6A4 NPY HTR2A BDNF
8 major depressive disorder 29.9 SLC6A4 NPY HTR2A HCRT GAL BDNF
9 hypochondriasis 29.7 SLC6A4 HTR2A CFI BDNF
10 antisocial personality disorder 29.7 SLC6A4 HTR2A CFI
11 melancholia 29.7 SLC6A4 HTR2A BDNF
12 borderline personality disorder 29.6 SLC6A4 HTR2A BDNF
13 substance abuse 29.6 SLC6A4 OGN NPY HTR2A BDNF
14 sleep disorder 29.6 SLC6A4 HTR2A HCRT BDNF
15 social phobia 29.6 SLC6A4 CGAS CFI BDNF
16 schizoaffective disorder 29.5 SLC6A4 HTR2A BDNF
17 alcohol use disorder 29.5 SLC6A4 HTR2A GAL BDNF
18 dysthymic disorder 29.3 SLC6A4 SCLY HTR2A HCRT CGAS CFI
19 psychotic disorder 29.3 SLC6A4 HTR2A CFI BDNF
20 generalized anxiety disorder 29.3 TSPO SLC6A4 NPY HTR2A BDNF
21 eating disorder 29.2 SLC6A4 NPY HTR2A HCRT BDNF
22 disease of mental health 29.2 SLC6A4 NPY HTR2A HCRT BDNF
23 somatization disorder 29.2 SLC6A4 SCLY HTR2A FLNA DCXR
24 agoraphobia 29.1 SLC6A4 SCLY HTR2A CFI BDNF
25 anxiety 29.1 TSPO SLC6A4 NPY HTR2A HCRT GAL
26 alcohol dependence 28.7 TSPO SLC6A4 NPY HTR2A HCRT BDNF
27 inhibited male orgasm 10.5 SLC6A4 OGN
28 uterine corpus sarcoma 10.5 INSRR FLNA
29 von economo's disease 10.4 HCRT GAL
30 narcissistic personality disorder 10.4 FLNA CFI
31 synovium neoplasm 10.3 FLNA EHD1
32 hematuria, benign familial 10.3 NPY HCRT GAL
33 alcoholic psychosis 10.3 SLC6A4 HTR2A
34 alzheimer disease 15 10.3 PPP2R3B INSRR
35 intermittent explosive disorder 10.3 SLC6A4 HTR2A
36 tendinosis 10.3 NPY BDNF
37 obsessive-compulsive personality disorder 10.3 SLC6A4 HTR2A
38 psychosexual disorder 10.3 SLC6A4 HTR2A
39 postpartum depression 10.3 SLC6A4 SCLY BDNF
40 drug dependence 10.3 SLC6A4 NPY BDNF
41 barbiturate dependence 10.2 SLC6A4 EHD1
42 normal pressure hydrocephalus 10.2 NPY HCRT BDNF
43 chronic dacryocystitis 10.2 FLNA DCXR
44 dacryocystitis 10.2 FLNA DCXR
45 senile entropion 10.2 FLNA DCXR
46 acute inflammation of lacrimal passage 10.2 FLNA DCXR
47 cyclothymic disorder 10.2 LAMB2 HTR2A CGAS
48 central hypoventilation syndrome, congenital 10.2 HCRT GAL BDNF
49 bruxism 10.2 SLC6A4 HTR2A HCRT
50 separation anxiety disorder 10.2 SLC6A4 LXN CGAS

Comorbidity relations with Adjustment Disorder via Phenotypic Disease Network (PDN):

Acute Cystitis Anxiety
Deficiency Anemia Dysthymic Disorder
Heart Disease Hypertension, Essential
Major Depressive Disorder Schizophreniform Disorder

Graphical network of the top 20 diseases related to Adjustment Disorder:

Diseases related to Adjustment Disorder

Symptoms & Phenotypes for Adjustment Disorder

MGI Mouse Phenotypes related to Adjustment Disorder:

# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.73 BDNF CGAS FLNA GAL HCRT HTR2A
2 homeostasis/metabolism MP:0005376 9.44 BDNF CFI CGAS EHD1 FLNA GAL

Drugs & Therapeutics for Adjustment Disorder

Drugs for Adjustment Disorder (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 28)
# Name Status Phase Clinical Trials Cas Number PubChem Id
Dopamine Approved Phase 3 51-61-6, 62-31-7 681
Risperidone Approved, Investigational Phase 3 106266-06-2 5073
Propranolol Approved, Investigational Phase 2, Phase 3 525-66-6 4946
Dexmedetomidine Approved, Vet_approved Phase 2, Phase 3 113775-47-6 5311068 68602
Sevoflurane Approved, Vet_approved Phase 2, Phase 3 28523-86-6 5206
6 Psychotropic Drugs Phase 3
7 Dopamine Agents Phase 3
8 Dopamine Antagonists Phase 3
9 Antipsychotic Agents Phase 3
10 Adrenergic beta-Antagonists Phase 2, Phase 3
11 Antihypertensive Agents Phase 2, Phase 3
12 Adrenergic Agents Phase 2, Phase 3
13 Adrenergic Antagonists Phase 2, Phase 3
14 Anti-Arrhythmia Agents Phase 2, Phase 3
15 Vasodilator Agents Phase 2, Phase 3
16 Neurotransmitter Agents Phase 2, Phase 3
17 Adrenergic alpha-Agonists Phase 2, Phase 3
18 Hypnotics and Sedatives Phase 2, Phase 3
19 Analgesics Phase 2, Phase 3
20 Anesthetics Phase 2, Phase 3
21 Analgesics, Non-Narcotic Phase 2, Phase 3
22 Adrenergic Agonists Phase 2, Phase 3
Serotonin Investigational, Nutraceutical Phase 3 50-67-9 5202
24 Pharmaceutical Solutions Phase 1
Nicotine Approved 54-11-5 942 89594
tannic acid Approved 1401-55-4
Benzocaine Approved, Investigational 94-09-7, 1994-09-7 2337
28 Antidepressive Agents

Interventional clinical trials:

(show top 50) (show all 60)
# Name Status NCT ID Phase Drugs
1 The Efficacy of Eye Movement Desensitization and Reprocessing (EMDR) in Patients With Post Traumatic Stress Disorder in Multiple Sclerosis. A Randomized Controlled Trial. Unknown status NCT01743664 Phase 3
2 Effects of Risperidone on Cognitive-Motor Performance and Motor Movements in Chronically Medicated Children Completed NCT00399698 Phase 3 Risperdal
3 Treating Adjustment Disorders Stemming From Romantic Betrayals: An Open-label Trial of Impairing Memory Reconsolidation Using Propranolol Recruiting NCT03151681 Phase 2, Phase 3 Propranolol Pill
4 Transbucal Dexmedetomidine for the Prevention of Emergence Agitation After Sevoflurane Anaesthesia in Pre-school Children Recruiting NCT02720705 Phase 2, Phase 3 Dexmedetomidine;saline
5 The Efficacy of Parent Involvement in the Treatment of Adolescent Depression Completed NCT00883519 Phase 1, Phase 2
6 The Impact of Integrating Emotion Focused Components Into Psychological Therapy Completed NCT02822443 Phase 2
7 Group Interpersonal Psychotherapy for Depressed Adolescents (IPT-AG) in School-based Clinics Completed NCT00270244 Phase 2
8 Post-traumatic Stress Disorders in Police, Correctional Service Officers, and 911 Operators: A Cost-effectiveness and Efficacy Comparison of Treatment as Usual and a Novel Intervention Recruiting NCT03152175 Phase 2 Propranolol Hydrochloride;Placebo
9 A Phase 2a Open-label Study of the Efficacy and Safety of PRN PH94B Neuroactive Nasal Spray in the Treatment of Adjustment Disorder With Anxiety (AjDA) Associated With COVID-19 Not yet recruiting NCT04404192 Phase 2 PH94B
10 An Open Clinical Trial of Interpersonal Psychotherapy for Depressed Adolescence and Parents Completed NCT00619411 Phase 1
11 Psychological First Aid With Children in a High Risk Group - a Repeated Single Case Design Completed NCT01612104 Phase 1
12 Does an Integrative Neuro-psychotherapy Program Foster the Adjustment in Depressed Stroke Patients? A Randomized Controlled Study. Terminated NCT01039857 Phase 1
13 Psychological Flexibility and Effectiveness of Psychotherapy Treatment in Patients With Adjustment Disorder Unknown status NCT02291068
14 Do Women Seeking Medical Assistance for Lower Urinary Tract Symptoms Have a High Prevalence of Adjustment Disorder?A Questionnaire Based Study Unknown status NCT03444740
15 Neuropattern - Clinical Trial of a Psychobiological Stress Diagnostic Tool (Neuropattern - Erprobung Einer Psychobiologischen Stressdiagnostik) Unknown status NCT01062880
16 Randomized Study of Ambulatory Monitoring Nurse Under the Prevention of Recurrent Suicidal Unknown status NCT02721316
17 Creating Meaning Following Cancer: An Cognitive-existential Intervention to Improve Existential and Global Quality of Life Unknown status NCT01141933
18 Effects of Mindfulness Based Cognitive Therapy on Emotional Processing Unknown status NCT03358056
19 Internet-based Cognitive Behavior Therapy for Stress Disorders: a Randomized Trial Completed NCT02540317
20 Study of the Psychometric Properties of the Scale of Well-being at Work: The Serenat Study Completed NCT02905071
21 Efficiency of Screening for Depression in Cancer Patients Receiving Radiotherapy Completed NCT00951184
22 Psychiatric Day Hospital Treatment Completed NCT00153959
23 Differential Efficacy of Two Ways of Applying Homework Assignments in the Treatment of Adjustment Disorders: Application Supported by Information and Communication Technologies Versus Traditional Application Completed NCT02452411
24 ZIEL - Zurück Ins Eigene Leben - Internet-based Self-help for Negative Life Events Completed NCT03379155
25 Effectiveness of Musical Training in Reducing Depressive Symptoms, Enhancing Self-esteem and Quality of Life Among Hong Kong Chinese Childhood Brain Tumor Survivors - A Pilot Randomized Controlled Trial Completed NCT03399864
26 Couples Coping With Multimorbidity: Does Solitary Expressive Writing Foster Psycho-social Adaptation? Completed NCT01912157
27 Registry of Mastectomy for Breast Cancer Risk Reduction Completed NCT00555503
28 Promoting Wellbeing in Military Spouses With Training Completed NCT03308344
29 Reducing Distress and Depressive-symptoms in Rural Women Using CaringGuidance™-After Breast Cancer Diagnosis: Randomized Controlled Pilot Study Completed NCT03465813
30 Return to Work Among Patients With Stress Related Mental Disorders - An Intervention in the Swedish Primary Care (PRIMA) Completed NCT03022760
31 Treating Cancer-Related Fatigue Through Systematic Light Exposure Completed NCT01873794
32 Outcomes of the Work Rehabilitation Method Redesigning Daily Occupations (ReDO) - a Quasi-experimental Study Among Women With Stress-related Disorders Completed NCT01234961
33 Therapeutic Termination of Pregnancy: Maternal and Paternal Mental Health Before and in the Long-term Completed NCT04080141
34 An Investigation to Examine a Telephone Based Stress Management and Coping Skills Intervention for Patients Waiting for Lung Transplant Completed NCT00113139
35 MINDFUL-PC: Integrating Mindfulness Into the Patient-Centered Medical Home - A Pilot Study Completed NCT02972203
36 SAFARI-Return to Work: Promoting Health and Productivity in Workers With Common Mental Disorders Completed NCT01805583
37 Effectiveness of Two Stress Management Programs in the Adaptation Disorder With Anxiety (ADA) : Computer-based or Face- to -Face to Face Versus Control Group.Open Multicenter Prospective Randomized Controlled Therapeutic 3 Parallel Groups Recruiting NCT02621775
38 Treatment of Depression: Efficacy and Efficiency of Two Self-administered Online Intervention Protocols Based on Behavioral Activation and Physical Activity Recruiting NCT02369393
39 A Problem Solving Based Intervention in Primary Health Care for Facilitating Return-to-work Among People Suffering From Common Mental Disorders - a Cluster-randomized Trial Recruiting NCT03346395
40 Development and Validation of a New Instrument to Evaluate Parents' Adjustment to Their Child's Chronic Disease: the Family Adjustment Inventory Recruiting NCT04049890
41 Randomized Controlled Trial (RCT) to Evaluate the Efficacy and Cost-effectiveness of an Internet-based Self-help Program for People With Adjustment Problems After an Accident Recruiting NCT03785912
42 MINDFUL-PC for Portuguese Speakers Pilot #2 Study 2020 (Integrating Mindfulness Into the Patient-Centered Medical Home) Recruiting NCT04268355
43 The Efficacy of a Depression Intervention for Adolescents With Depression and Sleep Disturbances Recruiting NCT02429674
44 Mindfulness Influences on Self-regulation: Mental and Physical Health Implications -- Integrating Mindfulness Into the Patient-Centered Medical Home (Phase 3) Recruiting NCT03609450
45 Effectiveness of a Mindfulness Smartphone App ("Staying Calm in the OR") to Reduce Distress in People With Cancer Waiting for Surgery: A Randomized Controlled Trial Recruiting NCT04184557
46 Bounce Back Now: A Low-Cost Intervention to Facilitate Post-Disaster Recovery Recruiting NCT03403738
47 Piloting an ICU Follow-up Clinic to Improve Health Related Quality of Life After a Prolonged Intensive Care Stay Recruiting NCT04186468
48 Efficacy of an Internet-based CBT Program for Adjustment Disorders: A Randomized Controlled Trial Active, not recruiting NCT02758418
49 Integrated Mental Health Care and Vocational Rehabilitation to Individuals on Sick Leave Due to Burnout, Adjustment Disorder or Psychological Stress in Denmark (the Danish IBBIS Study): A Multi-center Randomized Controlled Trial Active, not recruiting NCT02885519
50 Multiprofessional Rehabilitation for Exhaustion Disorder Active, not recruiting NCT03360136

Search NIH Clinical Center for Adjustment Disorder

Genetic Tests for Adjustment Disorder

Anatomical Context for Adjustment Disorder

MalaCards organs/tissues related to Adjustment Disorder:

Eye, Breast, Brain, Lung, Liver, Heart, Testes

Publications for Adjustment Disorder

Articles related to Adjustment Disorder:

(show top 50) (show all 1114)
# Title Authors PMID Year
A blended cognitive behavioral intervention for patients with adjustment disorder with anxiety: A randomized controlled trial. 61
32523873 2020
[Diagnosis of psychological aspects in chronic pruritus]. 61
32347353 2020
Is romantic partner betrayal a form of traumatic experience?: A qualitative study. 61
32533575 2020
Irritability Disorders in Adults: Diagnostic Categories Missing in Plain Sight? 61
32187127 2020
Postoperative Psychological Disorders Among Heart Transplant Recipients: A Meta-Analysis and Meta-regression. 61
32541547 2020
Increased incidence of stress-associated illnesses among elderly after Typhoon Morakot. 61
32505592 2020
Therapeutic Interventions for Adjustment Disorder: A Systematic Review. 61
32520732 2020
Symptoms of adjustment disorder and smoking predict long-term functional outcome after ankle and lower leg fracture. 61
32495846 2020
Factors Associated with Adjustment Disorder - the Different Contribution of Daily Stressors and Traumatic Events and the Mediating Role of Psychological Well-Being. 61
32562150 2020
Association of Early Treatment With Chronicity and Hazard of Hospitalization After New Adjustment Disorder. 61
31994408 2020
Adjustment and coronavirus: How to prepare for COVID-19 pandemic-related adjustment disorder worldwide? 61
32551753 2020
A Report of the Telepsychiatric Evaluation of SARS-CoV-2 Patients. 61
32525755 2020
Changing characteristics of a Psychiatric Emergency Care Centre. An eight year follow-up study. 61
29737196 2020
The efficacy, safety and acceptability of emergency embedded Psychiatry Assessment and Planning Units: An evaluation of Psychiatry Assessment and Planning Units in close proximity to their associated emergency departments. 61
31973563 2020
The validity and reliability of the PHQ-9 in screening for post-stroke depression. 61
32517743 2020
32574807 2020
Caffeinated Coffee and Tea Consumption, Genetic Variation and Cognitive Function in the UK Biobank. 61
32495843 2020
Querulant delusion and post-traumatic embitterment disorder. 61
32427007 2020
Adjustment Disorder in Female Breast Cancer Patients: Prevalence and Its Accessory Symptoms. 61
32474858 2020
Psychological Morbidity and Chronic Disease Among Adults With Traumatic Spinal Cord Injuries: A Longitudinal Cohort Study of Privately Insured Beneficiaries. 61
32299672 2020
Associations between adjustment disorder and hospital-based infections in the Danish population. 61
32142971 2020
Rapamycin increases the incidence of neuropsychiatric illness in kidney transplant patients through the suppression of neural stem cells. 61
32424120 2020
How do adolescents with Adjustment Disorder cope with stressful situations? Relationship with suicidal risk. 61
30558955 2020
Audit of Gastrointestinal Manifestations in Patients with Loeys-Dietz Syndrome and Vascular Ehlers-Danlos Syndrome. 61
32306189 2020
Depression in the medically ill. 61
31749372 2020
One-Year Postpartum Mental Health Outcomes of Mothers of Infants with Neonatal Abstinence Syndrome. 61
31925632 2020
Association of Stress-Related Disorders With Subsequent Neurodegenerative Diseases. 61
32150226 2020
A Cohort Study of Psychotropic Prescription Drug Use in Pregnancy in British Columbia, Canada from 1997 to 2010. 61
32176573 2020
Measuring ICD-11 adjustment disorder: the development and initial validation of the International Adjustment Disorder Questionnaire. 61
31721147 2020
A Comparison of Self-Harm Presentations to Emergency Services. 61
32141332 2020
Pediatric fibrocartilaginous embolism inducing paralysis. 61
31659479 2020
Outreach Psychiatric Emergency Service. 61
32036703 2020
Pharmacotherapy of psychiatric inpatients with adjustment disorder: current status and changes between 2000 and 2016. 61
31440829 2020
Alcohol Consumption or Excessive Use of Psychotropic Medication Prior to Suicidal Self-injury in Patients with Adjustment Disorder, Depression, and Schizophrenia: A Cross-sectional Study. 61
32099248 2020
Assessing and treating complex mental health needs among homeless youth in a shelter-based clinic. 61
32046711 2020
Positive and Negative Affect Schedule (PANAS): psychometric properties of the online Spanish version in a clinical sample with emotional disorders. 61
32039720 2020
Mental health conditions in bereaved military service widows: A prospective, case-controlled, and longitudinal study. 61
31765052 2020
Clinical Features and Long-Term Outcomes of Living Donors of Liver Transplantation Who Developed Psychiatric Disorders. 61
32001667 2020
The Unholy Trinity: Childhood Trauma, Adulthood Anxiety, and Long-Term Pain. 61
31936285 2020
Metacognitive Therapy for Adjustment Disorder in a Patient With Newly Diagnosed Pulmonary Arterial Hypertension: A Case Report. 61
32116944 2020
Adherence Predictors in Internet-Delivered Self-Help Intervention for Life Stressors-Related Adjustment Disorder. 61
32231597 2020
Risk factors of ICD-11 adjustment disorder in the Lithuanian general population exposed to life stressors. 61
32002141 2020
A cross-country psychiatric screening of ICD-11 disorders specifically associated with stress in Kenya, Nigeria and Ghana. 61
32128047 2020
Prevalence of adjustment disorder among cancer patients, and the reach, effectiveness, cost-utility and budget impact of tailored psychological treatment: study protocol of a randomized controlled trial. 61
31870421 2019
[Post-traumatic stress disorder and psychogenic pain]. 61
31864517 2019
Somatization and Coping in Ethnic Minority Recruits. 61
30793179 2019
Social status and modern-type depression: A review. 61
31743626 2019
Treating a 16 Year Old with a History of Severe Bullying: Supplementing Cognitive Behavioural Therapy with EMDR within the Context of a Case Formulation Approach. 61
32318222 2019
Longitudinal associations between cardiorespiratory fitness and stress-related exhaustion, depression, anxiety and sleep disturbances. 61
31870352 2019
Self-Injury in Adolescents: A Five-Year Study of Characteristics and Trends. 61
31698397 2019

Variations for Adjustment Disorder

Expression for Adjustment Disorder

Search GEO for disease gene expression data for Adjustment Disorder.

Pathways for Adjustment Disorder

GO Terms for Adjustment Disorder

Cellular components related to Adjustment Disorder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 postsynapse GO:0098794 9.13 HCRT FLNA BDNF
2 secretory granule GO:0030141 8.8 HCRT GAL BDNF

Biological processes related to Adjustment Disorder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 neuropeptide signaling pathway GO:0007218 9.58 NPY HCRT GAL
2 memory GO:0007613 9.5 SLC6A4 HTR2A BDNF
3 temperature homeostasis GO:0001659 9.43 HTR2A HCRT
4 detection of temperature stimulus involved in sensory perception of pain GO:0050965 9.37 LXN HTR2A
5 response to drug GO:0042493 9.35 TSPO SLC6A4 HTR2A GAL BDNF
6 sleep GO:0030431 9.26 HTR2A HCRT
7 negative regulation of potassium ion transport GO:0043267 9.16 HTR2A HCRT
8 feeding behavior GO:0007631 8.92 NPY HCRT GAL BDNF

Molecular functions related to Adjustment Disorder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 serotonin binding GO:0051378 8.96 SLC6A4 HTR2A
2 neuropeptide hormone activity GO:0005184 8.8 NPY HCRT GAL

Sources for Adjustment Disorder

9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
31 HPO
32 ICD10
33 ICD10 via Orphanet
37 LifeMap
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
54 Novoseek
57 OMIM via Orphanet
61 PubMed
70 Tocris
72 UMLS via Orphanet
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