MCID: ADR008
MIFTS: 56

Adrenal Adenoma

Categories: Cancer diseases, Endocrine diseases, Rare diseases
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Aliases & Classifications for Adrenal Adenoma

MalaCards integrated aliases for Adrenal Adenoma:

Name: Adrenal Adenoma 11 19 53 14
Adenoma of the Adrenal Gland 11 19 75 5
Adrenal Incidentaloma 19 75 71
Adrenal Cortical Adenoma 19 71
Adrenocortical Adenoma 19

Classifications:



External Ids:

Disease Ontology 11 DOID:656
UMLS 71 C0206667 C2609247

Summaries for Adrenal Adenoma

GARD: 19 "Adenomas of the adrenal gland are non-cancerous (benign) tumors on the adrenal gland. Most do not cause any signs or symptoms. However, some may become ""active"" or ""functioning"" which means they produce hormones, often in excess of what the adrenal glands typically produce. High levels of these hormones may lead to complications, including primary aldosteronism, Cushing's syndrome and other medical conditions."

MalaCards based summary: Adrenal Adenoma, also known as adenoma of the adrenal gland, is related to adenoma and amenorrhea. An important gene associated with Adrenal Adenoma is MEN1 (Menin 1), and among its related pathways/superpathways are Metabolism and Disease. The drugs Racepinephrine and Dexamethasone acetate have been mentioned in the context of this disorder. Affiliated tissues include adrenal gland, prostate and pituitary, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Reduced mammosphere formation

Disease Ontology: 11 An endocrine organ benign neoplasm that is a benign tumor of the glandular type (adenoma) in the adrenal gland.

Wikipedia 75 Adenoma of the adrenal gland: An adenoma is a benign tumor of epithelial tissue with glandular origin, glandular characteristics, or... more...

Adrenal incidentaloma: In medical or research imaging, an incidental imaging finding (also called an incidentaloma) is an... more...

Related Diseases for Adrenal Adenoma

Diseases related to Adrenal Adenoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 466)
# Related Disease Score Top Affiliating Genes
1 adenoma 31.2 REN PRKAR1A POMC MEN1 MC2R HSD11B2
2 amenorrhea 30.9 POMC CYP17A1 CRH
3 premature ovarian failure 7 30.9 POMC CRH
4 pheochromocytoma 30.8 REN POMC MEN1 IGF2 CRH
5 pituitary-dependent cushing's disease 30.8 POMC MC2R CRH
6 adrenal cortical adenoma 30.8 REN PRKAR1A POMC MIR483 MEN1 MC2R
7 hypokalemia 30.6 REN POMC KCNJ5 HSD11B2 CYP17A1 CYP11B2
8 multiple endocrine neoplasia 30.5 PRKAR1A POMC MEN1 GNAS
9 intracranial hypertension 30.4 REN POMC HSD11B1
10 acne 30.4 POMC CYP21A2 CYP17A1 CRH
11 acth-independent cushing syndrome 30.4 PRKAR1A GNAS
12 hyperandrogenism 30.4 POMC IGF2 HSD11B1 CYP21A2 CYP17A1 CYP11A1
13 leydig cell tumor 30.4 CYP21A2 CYP17A1 CYP11A1
14 multiple endocrine neoplasia, type i 30.4 PRKAR1A POMC MIR483 MEN1 GNAS
15 gangliocytoma 30.3 POMC CRH
16 hemihyperplasia, isolated 30.3 IGF2 CDKN1C
17 acute adrenal insufficiency 30.3 POMC CYP21A2 CYP11A1
18 parathyroid adenoma 30.3 PRKAR1A MEN1 GNAS
19 pituitary adenoma 30.2 PRKAR1A POMC MEN1 GNAS CRH
20 prolactinoma 30.2 PRKAR1A POMC MEN1 GNAS
21 conn's syndrome 30.1 REN PRKAR1A POMC MIR483 MEN1 MC2R
22 polycystic ovary syndrome 30.1 POMC IGF2 HSD11B1 CYP21A2 CYP17A1 CYP11A1
23 precocious puberty, male-limited 30.1 POMC GNAS CYP21A2
24 46,xy sex reversal 2 30.1 MC2R CYP21A2 CYP17A1 CYP11B1 CYP11A1
25 hypopituitarism 30.1 POMC HSD11B1 CRH
26 chronic fatigue syndrome 30.0 POMC IGF2 CRH
27 pseudohermaphroditism 30.0 POMC CYP21A2 CYP17A1 CYP11B1 CYP11A1
28 mccune-albright syndrome 30.0 PRKAR1A POMC MEN1 MC2R GNAS
29 anovulation 30.0 MIR483 CYP21A2 CYP17A1 CRH
30 intrauterine growth retardation, metaphyseal dysplasia, adrenal hypoplasia congenita, and genital anomalies 30.0 MC2R CYP11A1 CDKN1C
31 pituitary gland disease 30.0 PRKAR1A POMC MEN1 GNAS CRH
32 adrenal hypoplasia, congenital 30.0 POMC MC2R CYP21A2 CYP11A1 CDKN1C
33 liddle syndrome 1 30.0 REN POMC KCNJ5 HSD11B2 CYP11B2 CYP11B1
34 growth hormone secreting pituitary adenoma 29.9 PRKAR1A POMC MEN1 GNAS
35 hyperthyroidism 29.9 REN POMC GNAS
36 functioning pituitary adenoma 29.9 PRKAR1A POMC MEN1 GNAS CRH
37 paraganglioma 29.9 REN POMC MEN1 IGF2
38 islet cell tumor 29.9 POMC MIR483 MEN1 IGF2
39 hypoglycemia 29.9 POMC KCNJ5 IGF2 CRH
40 lipid metabolism disorder 29.8 REN POMC MIR483 HSD11B1 CYP21A2 CYP17A1
41 beckwith-wiedemann syndrome 29.8 PRKAR1A MIR483 MEN1 IGF2 GNAS CDKN1C
42 acromegaly 29.8 POMC MEN1 IGF2 HSD11B1 GNAS CRH
43 wilms tumor 1 29.8 REN MIR483 IGF2 CDKN1C
44 hypoadrenocorticism, familial 29.8 REN POMC MC2R CYP21A2 CYP17A1 CYP11B2
45 osteoporosis 29.6 PRKAR1A MIR483 IGF2 HSD11B2 HSD11B1 GNAS
46 lipoid congenital adrenal hyperplasia 29.6 REN POMC MC2R HSD11B2 HSD11B1 CYP21A2
47 diabetes mellitus 29.5 REN POMC MEN1 KCNJ5 IGF2 HSD11B1
48 familial glucocorticoid deficiency 29.5 REN POMC MC2R CYP21A2 CYP17A1 CYP11B2
49 primary pigmented nodular adrenocortical disease 29.2 PRKAR1A POMC MIR483 MEN1 MC2R KCNJ5
50 acth-independent macronodular adrenal hyperplasia 29.1 PRKAR1A POMC MEN1 MC2R KCNJ5 GNAS

Graphical network of the top 20 diseases related to Adrenal Adenoma:



Diseases related to Adrenal Adenoma

Symptoms & Phenotypes for Adrenal Adenoma

GenomeRNAi Phenotypes related to Adrenal Adenoma according to GeneCards Suite gene sharing:

25 (show all 34)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-101 10.21 HSD11B2
2 Increased shRNA abundance (Z-score > 2) GR00366-A-104 10.21 HSD11B2
3 Increased shRNA abundance (Z-score > 2) GR00366-A-105 10.21 GIPR
4 Increased shRNA abundance (Z-score > 2) GR00366-A-113 10.21 GIPR
5 Increased shRNA abundance (Z-score > 2) GR00366-A-114 10.21 GIPR
6 Increased shRNA abundance (Z-score > 2) GR00366-A-119 10.21 GIPR
7 Increased shRNA abundance (Z-score > 2) GR00366-A-120 10.21 HSD11B2
8 Increased shRNA abundance (Z-score > 2) GR00366-A-121 10.21 GIPR
9 Increased shRNA abundance (Z-score > 2) GR00366-A-147 10.21 HSD11B2
10 Increased shRNA abundance (Z-score > 2) GR00366-A-16 10.21 CDKN1C
11 Increased shRNA abundance (Z-score > 2) GR00366-A-161 10.21 HSD11B2
12 Increased shRNA abundance (Z-score > 2) GR00366-A-177 10.21 GIPR
13 Increased shRNA abundance (Z-score > 2) GR00366-A-179 10.21 GIPR
14 Increased shRNA abundance (Z-score > 2) GR00366-A-191 10.21 HSD11B2
15 Increased shRNA abundance (Z-score > 2) GR00366-A-195 10.21 GIPR
16 Increased shRNA abundance (Z-score > 2) GR00366-A-199 10.21 GIPR
17 Increased shRNA abundance (Z-score > 2) GR00366-A-205 10.21 CDKN1C
18 Increased shRNA abundance (Z-score > 2) GR00366-A-216 10.21 GIPR
19 Increased shRNA abundance (Z-score > 2) GR00366-A-29 10.21 GIPR
20 Increased shRNA abundance (Z-score > 2) GR00366-A-30 10.21 GIPR
21 Increased shRNA abundance (Z-score > 2) GR00366-A-43 10.21 GIPR
22 Increased shRNA abundance (Z-score > 2) GR00366-A-50 10.21 HSD11B2
23 Increased shRNA abundance (Z-score > 2) GR00366-A-51 10.21 CDKN1C GIPR HSD11B2
24 Increased shRNA abundance (Z-score > 2) GR00366-A-52 10.21 CDKN1C
25 Increased shRNA abundance (Z-score > 2) GR00366-A-56 10.21 CDKN1C
26 Increased shRNA abundance (Z-score > 2) GR00366-A-57 10.21 CDKN1C HSD11B2
27 Increased shRNA abundance (Z-score > 2) GR00366-A-59 10.21 GIPR
28 Increased shRNA abundance (Z-score > 2) GR00366-A-63 10.21 HSD11B2
29 Increased shRNA abundance (Z-score > 2) GR00366-A-66 10.21 GIPR
30 Increased shRNA abundance (Z-score > 2) GR00366-A-72 10.21 CDKN1C
31 Increased shRNA abundance (Z-score > 2) GR00366-A-87 10.21 GIPR
32 Increased shRNA abundance (Z-score > 2) GR00366-A-91 10.21 CDKN1C
33 Increased shRNA abundance (Z-score > 2) GR00366-A-98 10.21 GIPR
34 Reduced mammosphere formation GR00396-S 9.32 CYP11B1 CYP21A2 GIPR GNAS HSD11B2 IGF2

MGI Mouse Phenotypes related to Adrenal Adenoma:

45 (show all 15)
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.39 CDKN1C CRH CYP11A1 CYP11B1 CYP11B2 CYP17A1
2 growth/size/body region MP:0005378 10.34 CDKN1C CRH CYP11A1 CYP11B1 CYP11B2 CYP17A1
3 nervous system MP:0003631 10.31 CDKN1C CRH CYP11A1 CYP11B1 CYP11B2 GNAS
4 muscle MP:0005369 10.25 CDKN1C CYP11A1 CYP11B1 CYP11B2 GNAS HSD11B1
5 endocrine/exocrine gland MP:0005379 10.25 CDKN1C CRH CYP11A1 CYP11B1 CYP11B2 GADD45GIP1
6 renal/urinary system MP:0005367 10.22 CDKN1C CRH CYP11B1 CYP11B2 GNAS HSD11B2
7 cellular MP:0005384 10.21 CDKN1C CRH CYP11A1 CYP11B1 CYP11B2 CYP17A1
8 cardiovascular system MP:0005385 10.2 CDKN1C CYP11A1 CYP11B1 CYP11B2 CYP17A1 GNAS
9 liver/biliary system MP:0005370 10.19 CRH CYP11A1 CYP11B1 CYP11B2 GNAS HSD11B1
10 adipose tissue MP:0005375 10.18 CDKN1C CRH CYP11B1 CYP11B2 CYP17A1 GNAS
11 behavior/neurological MP:0005386 10.16 CDKN1C CRH CYP11A1 CYP11B1 CYP11B2 CYP17A1
12 normal MP:0002873 10.15 CDKN1C CRH CYP11A1 GNAS HSD11B2 MEN1
13 immune system MP:0005387 10 CDKN1C CRH CYP11A1 CYP11B1 CYP11B2 CYP21A2
14 hematopoietic system MP:0005397 9.77 CDKN1C CRH CYP11A1 CYP11B1 CYP11B2 CYP21A2
15 mortality/aging MP:0010768 9.5 CDKN1C CYP11A1 CYP11B1 CYP11B2 CYP17A1 CYP21A2

Drugs & Therapeutics for Adrenal Adenoma

Drugs for Adrenal Adenoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 51)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Racepinephrine Approved, Vet_approved Phase 4 51-43-4, 329-65-7 838 5816
2
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 4 1177-87-3 3680
3
Dexamethasone Approved, Investigational, Vet_approved Phase 4 50-02-2 3003 5743
4
Hydrocortisone succinate Approved Phase 4 2203-97-6 3643
5
Hydrocortisone acetate Approved, Vet_approved Phase 4 50-03-3
6
Hydrocortisone Approved, Vet_approved Phase 4 50-23-7 3640 5754
7
Nutmeg Approved Phase 4
8 Epinephryl borate Phase 4
9 Hydrocortisone 17-butyrate 21-propionate Phase 4
10 Mace Phase 4
11 Adrenocorticotropic Hormone Phase 3
12 Hormones Phase 3
13 glucocorticoids Phase 3
14 Melanocyte-Stimulating Hormones Phase 3
15
beta-Endorphin Phase 3
16 Hormone Antagonists Phase 2
17 Antineoplastic Agents, Hormonal Phase 2
18 Antiemetics Phase 2
19 Anti-Inflammatory Agents Phase 2
20 Gastrointestinal Agents Phase 2
21
Dopamine Approved 62-31-7, 51-61-6 681
22
Ethanol Approved 64-17-5 702
23
Zinc cation Approved, Experimental, Investigational 7440-66-6, 23713-49-7 32051
24
Amlodipine Approved 88150-42-9 2162
25
Diltiazem Approved, Investigational 42399-41-7 39186
26
Prazosin Approved 19216-56-9 4893
27
Angiotensin II Approved, Investigational 68521-88-0, 11128-99-7, 4474-91-3 172198
28
Spironolactone Approved 1952-01-7, 52-01-7 5833
29
Bisoprolol Approved 66722-44-9 2405
30
Indapamide Approved 26807-65-8 3702
31
Prasterone Approved, Investigational, Nutraceutical 53-43-0 5881
32 Insulin, Globin Zinc
33
Insulin
34 Hypoglycemic Agents
35 DHEA (Dehydroepiandrosterone)
36 Antihypertensive Agents
37 Bronchodilator Agents
38 Neurotransmitter Agents
39 Adrenergic beta-Agonists
40 Adrenergic alpha-Agonists
41 Anti-Asthmatic Agents
42 Adrenergic Agonists
43 Adrenergic Agents
44 Vasoconstrictor Agents
45 Respiratory System Agents
46 Mydriatics
47 Sympathomimetics
48
Angiotensinogen 16133225
49 Angiotensin-Converting Enzyme Inhibitors
50 Angiotensin Receptor Antagonists

Interventional clinical trials:

(show all 31)
# Name Status NCT ID Phase Drugs
1 An Oral GnRH Antagonist to Treat Mild Autonomous Cortisol Excess (MACE) Due to Adrenal Adenomas in Postmenopausal Women Recruiting NCT05038878 Phase 4 Elagolix
2 Glucocorticoid Receptor Antagonism in the Treatment of Hypercortisolism in Patients With Cortisol-Secreting Adrenal Adenomas or Hyperplasia: A Phase 3, Randomized, Double-Blind, Placebo-Controlled Study of the Efficacy and Safety of Relacorilant Recruiting NCT04308590 Phase 3 relacorilant
3 A Phase II, Open-label, Dose Titration, Multi-center Study to Assess the Safety/Tolerability and Efficacy of Osilodrostat in Patients With All Types of Endogenous Cushing's Syndrome Except Cushing's Disease Completed NCT02468193 Phase 2 Osilodrostat
4 A Multicenter Medical Safety Follow-up Study for Patients With Partial Onset Seizures Who Received More Than 28 Days of Total Exposure to BGG492 in Studies CBGG492A2207 and/or CBGG492A2212 Completed NCT02150213 Phase 2 BGG492
5 Feasibility Study of RadioFrequency Endoscopic ABlation, With ULtrasound Guidance, as a Non-surgical, Adrenal Sparing Treatment for Aldosterone-producing Adenomas Unknown status NCT03405025
6 Natural History of Benign Nonfunctioning Adrenal Tumors: 10 Year Follow-up Results Unknown status NCT04616703
7 Laparoscopic Adrenalectomy Versus Radiofrequency Ablation for Aldosterone-producing Adenoma: a Prospective Randomized Controlled Trial Unknown status NCT02030587
8 Expression of D2-Like Dopamine Receptor of Human Aldosterone-Producing Adenoma and Its Role in Regulation of Aldosterone Secretion and Cell Proliferation Unknown status NCT00173446
9 Evaluation of the Diagnostic Utility of Serum Dexamethasone Measurements in the Overnight 1mg Dexamethasone Suppression Test in Patients Investigated for Cushing's Syndrome and Incidentalomas Unknown status NCT01504555
10 Radiofrequency Ablation for Aldosterone-producting Adenoma in Patients With Primary Aldosteronism: Evaluation of the Blood Pressure Control and of Its Safety. Completed NCT02756754
11 Is There Anything New in the Field of Large Adrenal Tumors ? Completed NCT03830593
12 Studies of 18F-CETO as a Tracer for Adrenal PET Diagnostics Completed NCT05361083 Early Phase 1 F18CETO
13 Cardiovascular Risk in Patients With Non-Functional Adrenal Incidentaloma: Myth or Reality? Completed NCT00768365
14 The Prevalence and Characteristics of Adrenal Incidentaloma: A Prospective Study Completed NCT04682938
15 Effect of Chronic Catecholamine Overproduction on Brown Adipose Tissue Completed NCT01949714
16 Morbidity and Mortality in Patients With Adrenal Incidentalomas With and Without Autonomous Cortisol Secretion Completed NCT03919734
17 Complex Cystic Benign Adrenal Incidentalomas Mimicking Non-adenomatous Masses; Rare Pathologies: Clinical Features and Outcomes. Case Series With Short Review of Literature. Completed NCT03739918
18 Characteristics Predicting Clinically Relevant Reduction of Hypertension Following Adrenalectomy for Primary Aldosteronism: a Multicenter Analysis Completed NCT04761354
19 Prevention of Conversion in Posterior Retroperitoneal Adrenalectomy by Measuring Preoperative Anatomical Conditions on Cross-sectional Imaging (CT or MRI) Completed NCT04071561
20 China Adrenal Disease Registry Study Recruiting NCT04890444
21 Long-term Effects of Adrenalectomy on Metabolic Syndrome, Glucose Metabolism, Lipid Metabolism, and Bone Metabolism in Subclinical Cushing's Syndrome of Adrenal Incidentaloma Recruiting NCT01382420
22 Comparison of Imaging Quality Between Spectral Photon Counting Computed Tomography (SPCCT) and Dual Energy Computed Tomography (DECT) Recruiting NCT04328181
23 Impact of Adrenal IncidenTalomas and Possible Autonomous Cortisol Secretion on Cardiovascular and Metabolic Alterations (ITACA Study) Recruiting NCT04127552
24 The Cross-sectional Study and Longitudinal Study of the Diagnostic Efficiency of Serum Dehydroepiandrosterone Sulfate in Subclinical Hypercortisolism Recruiting NCT04833192
25 If Adrenal Incidentalomas Have the Influences to Occur and Progress in Patients With Stroke Recruiting NCT05237817
26 Structured Evaluation of adRENal Tumors Discovered Incidentally - Prospectively Investigating the Testing Yield Recruiting NCT02324647
27 A Single Center, Prospective, Observational Study to Explore and Evaluate the Differences of Cognitive Function and Brain Function Between Non-functioning Adrenal Adenomas and Autonomous Cortisol Secretion Patients, and the Different Treatments Methods on Cognitive Function and Brain Function in Patients With Autonomous Cortisol Secretion Recruiting NCT05357456
28 Effect of Surgical or Conservative Approach in Patients With Adrenal Incidentalomas on Cardiovascular, Metabolic, Neuropsychological and Bone Manifestations: Respective Roles of Cortisol Secretion and Glucocorticoid Sensitivity Active, not recruiting NCT04860180
29 Clinical Outcome of Autonomous Cortisol Secretion in Adrenal Incidentalomas - Substudy of the ENSAT (European Network for the Study of Adrenal Tumor) Registry Active, not recruiting NCT04917757
30 Surgery of Subclinical Cortisol Secreting Adrenal Incidentalomas Active, not recruiting NCT02364089 Standardized medical treatment of hypertension by SAHR
31 A Prospective Cohort Study for Patients With Adrenal Diseases Enrolling by invitation NCT03474237

Search NIH Clinical Center for Adrenal Adenoma

Genetic Tests for Adrenal Adenoma

Anatomical Context for Adrenal Adenoma

Organs/tissues related to Adrenal Adenoma:

MalaCards : Adrenal Gland, Prostate, Pituitary, Thyroid, Bone, Adrenal Cortex, Brain

Publications for Adrenal Adenoma

Articles related to Adrenal Adenoma:

(show top 50) (show all 3014)
# Title Authors PMID Year
1
MEN I gene mutations in sporadic adrenal adenomas. 62 5
10647896 1999
2
8Cl-cAMP modifies the balance between PKAR1 and PKAR2 and modulates the cell cycle, growth and apoptosis in human adrenocortical H295R cells. 53 62
20237143 2010
3
Estrogen biosynthesis in human H295 adrenocortical carcinoma cells. 53 62
19026713 2009
4
Diagnosis by serendipity: Cushing syndrome attributable to cortisol-producing adrenal adenoma as the initial manifestation of multiple endocrine neoplasia type 1 due to a rare splicing site MEN1 gene mutation. 53 62
18753104 2008
5
Elevated expression of luteinizing hormone receptor in aldosterone-producing adenomas. 53 62
16332935 2006
6
Prevalence of primary hyperaldosteronism assessed by aldosterone/renin ratio and spironolactone testing. 53 62
15745200 2005
7
Mild cutaneous manifestation in two young women with extraordinary hyperandrogenemia. 53 62
15604546 2005
8
Postoperative differentiation between unilateral adrenal adenoma and bilateral adrenal hyperplasia in primary aldosteronism by mRNA expression of the gene CYP11B2. 53 62
15248825 2004
9
Parental origin of Gsalpha mutations in the McCune-Albright syndrome and in isolated endocrine tumors. 53 62
15181091 2004
10
Adrenocortical adenoma associated with inadequately treated congenital adrenal hyperplasia. 53 62
14714757 2003
11
Clinical and molecular aspects of adrenocortical tumourigenesis. 53 62
12956790 2003
12
Characteristics of Cushing's syndrome in Taiwanese. 53 62
12874666 2003
13
The ectopic expression of the gastric inhibitory polypeptide receptor is frequent in adrenocorticotropin-independent bilateral macronodular adrenal hyperplasia, but rare in unilateral tumors. 53 62
11994328 2002
14
Circulating adrenomedullin is increased in patients with corticotropin-dependent Cushing's syndrome due to pituitary adenoma. 53 62
10877203 2000
15
The aldosterone/renin ratio as a screening test for primary aldosteronism. 53 62
10957926 2000
16
Virilizing adrenocortical adenoma: in vitro steroidogenesis, immunohistochemical studies of steroidogenic enzymes, and gene expression of corticotropin receptor. 53 62
10216530 1999
17
Diagnosis and management of Cushing's syndrome: results of an Italian multicentre study. Study Group of the Italian Society of Endocrinology on the Pathophysiology of the Hypothalamic-Pituitary-Adrenal Axis. 53 62
10022398 1999
18
Adrenomedullin levels are high in primary aldosteronism due to adenoma and decline after surgical cure. 53 62
9551873 1998
19
Adrenocorticotropin- and cortisol-releasing effect of hexarelin, a synthetic growth hormone-releasing peptide, in normal subjects and patients with Cushing's syndrome. 53 62
9253314 1997
20
Food-dependent Cushing's syndrome resulting from abundant expression of gastric inhibitory polypeptide receptors in adrenal adenoma cells. 53 62
8784063 1996
21
Cholera toxin can ADP-ribosylate Gs as well as Gi in ACTH-unresponsive human adrenocortical cancer. 53 62
7889122 1994
22
Virilizing adrenal tumour mimicking congenital adrenal hyperplasia with P450c11 (11 beta-hydroxylase) deficiency. 53 62
8088295 1994
23
Conn's syndrome due to a renin-responsive adrenal adenoma. 53 62
8505755 1993
24
[Does the captopril test improve the diagnosis of primary hyperaldosteronism?]. 53 62
1644014 1992
25
Cushing's syndrome induced by hypersecretion of cortisol from only one of bilateral adrenocortical tumors. 53 62
1542264 1992
26
Testosterone-secreting virilizing adrenal adenoma with human chorionic gonadotrophin receptors and 21-hydroxylase deficiency. 53 62
1848485 1991
27
Nonclassic Adrenal Hyperplasia (NCAH) due to 21-hydroxylase deficiency: A cohort of 78 patients. 62
36167262 2023
28
68Ga-DOTANOC PET/CT in Adrenal Schwannoma. 62
36469076 2023
29
68Ga-DOTATATE PET/CT of ACTH-Independent Cushing Syndrome Due to Ectopic Adrenocortical Adenoma. 62
36469068 2023
30
Evaluation of the T2-weighted (T2W) adrenal MRI calculator to differentiate adrenal pheochromocytoma from lipid-poor adrenal adenoma. 62
35680653 2022
31
Impact of dedicated multidisciplinary service on patient selection and outcomes for surgical treatment of primary aldosteronism. 62
36123178 2022
32
Adrenocortical adenoma arising from adreno-hepatic fusion: A pitfall for an overdiagnosis. 62
36468827 2022
33
Single-port robot-assisted retroperitoneal surgery: A feasible approach. 62
36272961 2022
34
Cardio-metabolic effects of mild glucocorticoid excess: Implications for management of adrenal incidentaloma. 62
36367077 2022
35
Detection of incidental adrenal nodules on computed tomography by radiographers. 62
35939961 2022
36
Approach to Fine Needle Aspiration of Adrenal Gland Lesions. 62
35878423 2022
37
Left adrenal aldosteronism coexisting with left paraaortic paraganglioma presenting as bilateral adrenal and left paraaortic tumors- comprehensive adrenal evaluation aiding perfect management: a case report. 62
36371163 2022
38
Adrenal Cushing's Syndrome Treated With Preoperative Osilodrostat and Adrenalectomy. 62
36447826 2022
39
Susceptibility and characteristics of infections in patients with glucocorticoid excess or insufficiency: the ICARO tool. 62
36102827 2022
40
Cost Analysis of Radiofrequency Ablation for Adrenal Adenoma in Patients with Primary Aldosteronism and Hypertension: Results from the ADERADHTA Pilot Study and Comparison with Surgical Adrenalectomy. 62
36380152 2022
41
Recurrent Cushing Syndrome From Metastatic Adrenocortical Carcinoma With Fumarate Hydratase Allelic Variant. 62
36447829 2022
42
Imaging of C-X-C Motif Chemokine Receptor 4 Expression in 690 Patients with Solid or Hematologic Neoplasms Using 68Ga-Pentixafor PET. 62
35241482 2022
43
Altered expression of the IGF2‑H19 locus and mitochondrial respiratory complexes in adrenocortical carcinoma. 62
36169175 2022
44
Mixed ganglioneuroma and cortical adenoma in adrenal gland: A case report. 62
36451378 2022
45
French AFU Cancer Committee Guidelines Update 2022-2024: Adrenal tumor -  Assessment of an adrenal incidetaloma and oncological management. 62
36400477 2022
46
Prevalence and Characteristics of Adrenal Tumors in an Unselected Screening Population : A Cross-Sectional Study. 62
36095315 2022
47
Automated extraction of incidental adrenal nodules from electronic health records. 62
36207197 2022
48
The combination of early identification, chemotherapy, and autologous stem cell transplantation obtained favorable outcomes in unilateral primary adrenal lymphoma: A case report. 62
36242752 2022
49
Diagnostic and prognostic utility of SF-1 in adrenal cortical tumours. 62
36308186 2022
50
Prevalence and phenotype of primary bilateral macronodular adrenal hyperplasia with autonomous cortisol secretion: a study of 98 patients. 62
35597729 2022

Variations for Adrenal Adenoma

ClinVar genetic disease variations for Adrenal Adenoma:

5
# Gene Name Type Significance ClinVarId dbSNP ID Position
1 MEN1 NM_001370259.2(MEN1):c.1654A>T (p.Thr552Ser) SNV Pathogenic
16698 rs121913035 GRCh37: 11:64571985-64571985
GRCh38: 11:64804513-64804513

Cosmic variations for Adrenal Adenoma:

8 (show top 50) (show all 874)
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM142561722 TP53 adrenal gland,adrenal gland,adrenal cortical adenoma,NS c.619A>G p.M207V 17:7674227-7674227 7
2 COSM142839625 TP53 adrenal gland,adrenal gland,adrenal cortical adenoma,NS c.587G>T p.R196L 17:7674944-7674944 7
3 COSM112301864 TP53 adrenal gland,adrenal gland,adrenal cortical adenoma,NS c.305C>T p.T102I 17:7676064-7676064 7
4 COSM142838509 TP53 adrenal gland,adrenal gland,adrenal cortical adenoma,NS c.736A>G p.M246V 17:7674227-7674227 7
5 COSM111765171 TP53 adrenal gland,adrenal gland,adrenal cortical adenoma,NS c.775G>T p.D259Y 17:7674188-7674188 7
6 COSM144658124 TP53 adrenal gland,adrenal gland,adrenal cortical adenoma,NS c.658G>T p.D220Y 17:7674188-7674188 7
7 COSM93233747 TP53 adrenal gland,adrenal gland,adrenal cortical adenoma,NS c.305C>T p.T102I 17:7676064-7676064 7
8 COSM105679498 TP53 adrenal gland,adrenal gland,adrenal cortical adenoma,NS c.305C>T p.T102I 17:7676064-7676064 7
9 COSM145062246 TP53 adrenal gland,adrenal gland,adrenal cortical adenoma,NS c.188C>T p.T63I 17:7676064-7676064 7
10 COSM93186843 TP53 adrenal gland,adrenal gland,adrenal cortical adenoma,NS c.587G>T p.R196L 17:7674944-7674944 7
11 COSM121883757 TP53 adrenal gland,adrenal gland,adrenal cortical adenoma,NS c.379G>T p.D127Y 17:7674188-7674188 7
12 COSM144058329 TP53 adrenal gland,adrenal gland,adrenal cortical adenoma,NS c.305C>T p.T102I 17:7676064-7676064 7
13 COSM143159410 TP53 adrenal gland,adrenal gland,adrenal cortical adenoma,NS c.110G>T p.R37L 17:7674944-7674944 7
14 COSM144654685 TP53 adrenal gland,adrenal gland,adrenal cortical adenoma,NS c.470G>T p.R157L 17:7674944-7674944 7
15 COSM106100323 TP53 adrenal gland,adrenal gland,adrenal cortical adenoma,NS c.305C>T p.T102I 17:7676064-7676064 7
16 COSM112256303 TP53 adrenal gland,adrenal gland,adrenal cortical adenoma,NS c.587G>T p.R196L 17:7674944-7674944 7
17 COSM143417242 TP53 adrenal gland,adrenal gland,adrenal cortical adenoma,NS c.188C>T p.T63I 17:7676064-7676064 7
18 COSM112255048 TP53 adrenal gland,adrenal gland,adrenal cortical adenoma,NS c.736A>G p.M246V 17:7674227-7674227 7
19 COSM144701288 TP53 adrenal gland,adrenal gland,adrenal cortical adenoma,NS c.188C>T p.T63I 17:7676064-7676064 7
20 COSM122277678 TP53 adrenal gland,adrenal gland,adrenal cortical adenoma,NS c.379G>T p.D127Y 17:7674188-7674188 7
21 COSM144313019 TP53 adrenal gland,adrenal gland,adrenal cortical adenoma,NS c.470G>T p.R157L 17:7674944-7674944 7
22 COSM111807159 TP53 adrenal gland,adrenal gland,adrenal cortical adenoma,NS c.305C>T p.T102I 17:7676064-7676064 7
23 COSM122740139 TP53 adrenal gland,adrenal gland,adrenal cortical adenoma,NS c.379G>T p.D127Y 17:7674188-7674188 7
24 COSM143162027 TP53 adrenal gland,adrenal gland,adrenal cortical adenoma,NS c.298G>T p.D100Y 17:7674188-7674188 7
25 COSM93185288 TP53 adrenal gland,adrenal gland,adrenal cortical adenoma,NS c.736A>G p.M246V 17:7674227-7674227 7
26 COSM144315359 TP53 adrenal gland,adrenal gland,adrenal cortical adenoma,NS c.658G>T p.D220Y 17:7674188-7674188 7
27 COSM87955161 TP53 adrenal gland,adrenal gland,adrenal cortical adenoma,NS c.305C>T p.T102I 17:7676064-7676064 7
28 COSM121878377 TP53 adrenal gland,adrenal gland,adrenal cortical adenoma,NS c.340A>G p.M114V 17:7674227-7674227 7
29 COSM112259562 TP53 adrenal gland,adrenal gland,adrenal cortical adenoma,NS c.775G>T p.D259Y 17:7674188-7674188 7
30 COSM144349981 TP53 adrenal gland,adrenal gland,adrenal cortical adenoma,NS c.188C>T p.T63I 17:7676064-7676064 7
31 COSM144089266 TP53 adrenal gland,adrenal gland,adrenal cortical adenoma,NS c.110G>T p.R37L 17:7674944-7674944 7
32 COSM122274519 TP53 adrenal gland,adrenal gland,adrenal cortical adenoma,NS c.191G>T p.R64L 17:7674944-7674944 7
33 COSM122273238 TP53 adrenal gland,adrenal gland,adrenal cortical adenoma,NS c.340A>G p.M114V 17:7674227-7674227 7
34 COSM144311602 TP53 adrenal gland,adrenal gland,adrenal cortical adenoma,NS c.619A>G p.M207V 17:7674227-7674227 7
35 COSM143949177 TP53 adrenal gland,adrenal gland,adrenal cortical adenoma,NS c.298G>T p.D100Y 17:7674188-7674188 7
36 COSM106059381 TP53 adrenal gland,adrenal gland,adrenal cortical adenoma,NS c.775G>T p.D259Y 17:7674188-7674188 7
37 COSM142876232 TP53 adrenal gland,adrenal gland,adrenal cortical adenoma,NS c.305C>T p.T102I 17:7676064-7676064 7
38 COSM143374128 TP53 adrenal gland,adrenal gland,adrenal cortical adenoma,NS c.470G>T p.R157L 17:7674944-7674944 7
39 COSM111762017 TP53 adrenal gland,adrenal gland,adrenal cortical adenoma,NS c.587G>T p.R196L 17:7674944-7674944 7
40 COSM142610553 TP53 adrenal gland,adrenal gland,adrenal cortical adenoma,NS c.188C>T p.T63I 17:7676064-7676064 7
41 COSM87905712 TP53 adrenal gland,adrenal gland,adrenal cortical adenoma,NS c.775G>T p.D259Y 17:7674188-7674188 7
42 COSM105627143 TP53 adrenal gland,adrenal gland,adrenal cortical adenoma,NS c.775G>T p.D259Y 17:7674188-7674188 7
43 COSM142562947 TP53 adrenal gland,adrenal gland,adrenal cortical adenoma,NS c.470G>T p.R157L 17:7674944-7674944 7
44 COSM144088172 TP53 adrenal gland,adrenal gland,adrenal cortical adenoma,NS c.259A>G p.M87V 17:7674227-7674227 7
45 COSM145024418 TP53 adrenal gland,adrenal gland,adrenal cortical adenoma,NS c.658G>T p.D220Y 17:7674188-7674188 7
46 COSM144015059 TP53 adrenal gland,adrenal gland,adrenal cortical adenoma,NS c.703A>G p.M235V 17:7674227-7674227 7
47 COSM111760179 TP53 adrenal gland,adrenal gland,adrenal cortical adenoma,NS c.736A>G p.M246V 17:7674227-7674227 7
48 COSM144016557 TP53 adrenal gland,adrenal gland,adrenal cortical adenoma,NS c.554G>T p.R185L 17:7674944-7674944 7
49 COSM143945685 TP53 adrenal gland,adrenal gland,adrenal cortical adenoma,NS c.259A>G p.M87V 17:7674227-7674227 7
50 COSM145021138 TP53 adrenal gland,adrenal gland,adrenal cortical adenoma,NS c.470G>T p.R157L 17:7674944-7674944 7

Expression for Adrenal Adenoma

Search GEO for disease gene expression data for Adrenal Adenoma.

Pathways for Adrenal Adenoma

Pathways related to Adrenal Adenoma according to GeneCards Suite gene sharing:

(show all 16)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.65 PRKAR1A POMC HSD11B2 HSD11B1 GNAS CYP21A2
2
Show member pathways
13.56 PRKAR1A POMC MC2R GNAS CYP21A2 CYP17A1
3
Show member pathways
12.77 POMC CYP21A2 CYP17A1 CYP11B2 CYP11B1 CYP11A1
4
Show member pathways
12.56 POMC MC2R CYP21A2 CYP17A1 CYP11B2 CYP11B1
5
Show member pathways
12.52 CYP11A1 CYP11B1 CYP11B2 CYP17A1 CYP21A2 POMC
6
Show member pathways
12.46 CRH GNAS KCNJ5 POMC PRKAR1A
7
Show member pathways
12.42 CYP11A1 CYP11B1 CYP11B2 CYP17A1 CYP21A2 HSD11B1
8
Show member pathways
12.34 PRKAR1A KCNJ5 GNAS CRH
9
Show member pathways
12 PRKAR1A POMC MC2R GNAS GIPR CRH
10
Show member pathways
11.6 HSD11B2 HSD11B1 CYP11A1
11 11.59 POMC GNAS CYP21A2 CYP11B1 CYP11A1 CRH
12
Show member pathways
11.21 POMC HSD11B2 HSD11B1 CYP21A2 CYP17A1 CYP11B2
13 10.89 CYP21A2 CYP17A1 CYP11B2 CYP11B1 CYP11A1
14 10.59 CYP17A1 CYP11A1
15
Show member pathways
10.43 CYP11B2 CYP11A1
16 10.36 POMC CRH

GO Terms for Adrenal Adenoma

Biological processes related to Adrenal Adenoma according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 lipid metabolic process GO:0006629 10 CYP11A1 CYP11B1 CYP11B2 CYP17A1 CYP21A2 HSD11B1
2 sterol metabolic process GO:0016125 9.97 CYP11A1 CYP11B1 CYP11B2 CYP21A2
3 cellular response to peptide hormone stimulus GO:0071375 9.92 MEN1 CYP11B2 CYP11B1 CYP11A1
4 C21-steroid hormone biosynthetic process GO:0006700 9.88 CYP11B2 CYP11B1 CYP11A1
5 embryonic placenta morphogenesis GO:0060669 9.84 IGF2 CDKN1C
6 cortisol biosynthetic process GO:0034651 9.83 CYP11B2 CYP11B1
7 positive regulation of cAMP-mediated signaling GO:0043950 9.83 POMC GNAS GIPR
8 aldosterone biosynthetic process GO:0032342 9.81 CYP11B2 CYP11B1
9 mineralocorticoid biosynthetic process GO:0006705 9.8 CYP21A2 CYP11B2
10 steroid biosynthetic process GO:0006694 9.8 CYP21A2 CYP17A1 CYP11B2 CYP11B1 CYP11A1
11 regulation of blood volume by renal aldosterone GO:0002017 9.78 HSD11B2 CYP11B2
12 cortisol metabolic process GO:0034650 9.76 CYP11A1 CYP11B1 CYP11B2 HSD11B2
13 steroid metabolic process GO:0008202 9.65 HSD11B2 HSD11B1 CYP21A2 CYP17A1 CYP11B2 CYP11B1
14 glucocorticoid biosynthetic process GO:0006704 9.4 CYP21A2 CYP17A1 CYP11B2 CYP11B1 CYP11A1 CRH

Molecular functions related to Adrenal Adenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 heme binding GO:0020037 10.02 CYP11A1 CYP11B1 CYP11B2 CYP17A1 CYP21A2
2 iron ion binding GO:0005506 9.96 CYP21A2 CYP17A1 CYP11B2 CYP11B1 CYP11A1
3 steroid binding GO:0005496 9.93 HSD11B2 HSD11B1 CYP21A2
4 insulin-like growth factor receptor binding GO:0005159 9.85 REN IGF2 GNAS
5 oxidoreductase activity GO:0016491 9.81 HSD11B2 HSD11B1 CYP21A2 CYP17A1 CYP11B2 CYP11B1
6 corticosterone 18-monooxygenase activity GO:0047783 9.73 CYP11B2 CYP11B1
7 steroid 11-beta-monooxygenase activity GO:0004507 9.71 CYP11B2 CYP11B1
8 monooxygenase activity GO:0004497 9.35 CYP21A2 CYP17A1 CYP11B2 CYP11B1 CYP11A1
9 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen GO:0016705 9.02 CYP21A2 CYP17A1 CYP11B2 CYP11B1 CYP11A1

Sources for Adrenal Adenoma

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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