MCID: ADR008
MIFTS: 51

Adrenal Adenoma

Categories: Cancer diseases, Endocrine diseases, Rare diseases

Aliases & Classifications for Adrenal Adenoma

MalaCards integrated aliases for Adrenal Adenoma:

Name: Adrenal Adenoma 12 53 55 15
Adenoma of the Adrenal Gland 12 76 53 6
Adrenal Cortical Adenoma 53 73
Adrenal Incidentaloma 53 73
Adrenocortical Adenoma 53

Classifications:



External Ids:

Disease Ontology 12 DOID:656

Summaries for Adrenal Adenoma

NIH Rare Diseases : 53 Adenomas of the adrenal gland are non-cancerous (benign) tumors on the adrenal gland. Most do not cause any signs or symptoms and rarely require treatment. However, some may become "active" or "functioning" which means they produce hormones, often in excess of what the adrenal glands typically produce. High levels of these hormones can lead to complications, including primary aldosteronism, Cushing's syndrome and other medical conditions. Functioning adrenal adenomas may be treated with surgery and/or medications.

MalaCards based summary : Adrenal Adenoma, also known as adenoma of the adrenal gland, is related to adenoma and adrenal cortical adenoma. An important gene associated with Adrenal Adenoma is MEN1 (Menin 1), and among its related pathways/superpathways are Cytochrome P450 - arranged by substrate type and Aldosterone synthesis and secretion. The drugs Racepinephrine and Epinephrine have been mentioned in the context of this disorder. Affiliated tissues include adrenal gland, pituitary and prostate, and related phenotypes are Increased transferrin (TF) endocytosis and Reduced mammosphere formation

Disease Ontology : 12 An endocrine organ benign neoplasm that is a benign tumor of the glandular type (adenoma) in the adrenal gland.

Wikipedia : 76 An adenoma (from Greek αδένα�?, adeno-, "gland" + -�?μα, -oma, "tumor") (/�?ædɪ�?no�?m�?/; plural... more...

Related Diseases for Adrenal Adenoma

Diseases related to Adrenal Adenoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 166)
# Related Disease Score Top Affiliating Genes
1 adenoma 31.1 CYP11B2 CYP21A2 KCNJ5 MEN1 POMC
2 adrenal cortical adenoma 31.1 CYP11A1 CYP11B1 CYP17A1 CYP21A2 GIPR MC2R
3 adrenal carcinoma 30.3 CRH CYP11A1 CYP11B1 CYP11B2 CYP17A1 CYP21A2
4 aldosterone-producing adenoma 30.1 CYP11B2 CYP21A2 KCNJ5
5 hyperandrogenism 29.8 CYP17A1 CYP21A2 HSD11B1 POMC
6 leydig cell tumor 29.8 CYP11A1 CYP17A1 CYP21A2
7 pheochromocytoma 29.7 CRH MEN1 POMC REN
8 pituitary gland disease 29.6 CRH MEN1 POMC
9 hypoadrenocorticism, familial 29.1 CRH CYP11A1 CYP21A2 MC2R POMC
10 hypertension, essential 28.9 CYP11B1 CYP11B2 MEN1 POMC REN
11 adrenocortical carcinoma, hereditary 28.8 CRH CYP11A1 CYP11B1 CYP11B2 CYP17A1 CYP21A2
12 conn's syndrome 28.8 CRH CYP11A1 CYP11B1 CYP11B2 CYP17A1 CYP21A2
13 lipoid congenital adrenal hyperplasia 28.7 CYP11A1 CYP11B1 CYP11B2 CYP17A1 CYP21A2 MC2R
14 hyperaldosteronism, familial, type ii 11.3
15 acth-independent macronodular adrenal hyperplasia 11.1
16 primary pigmented nodular adrenocortical disease 11.1
17 transsexualism 10.2 CYP17A1 CYP21A2
18 classic congenital adrenal hyperplasia due to 21-hydroxylase deficiency 10.2 CYP21A2 POMC
19 antley-bixler syndrome 10.2 CYP17A1 CYP21A2
20 autoimmune polyendocrine syndrome, type i, with or without reversible metaphyseal dysplasia 10.1 CYP11A1 CYP17A1 CYP21A2
21 cytochrome p450 oxidoreductase deficiency 10.1 CYP17A1 CYP21A2 POMC
22 sex differentiation disease 10.1 CYP17A1 CYP21A2 POMC
23 polycystic ovary syndrome 10.1 CYP11A1 CYP17A1 CYP21A2
24 glucocorticoid deficiency 1 10.1 MC2R POMC
25 hypothalamic disease 10.1 CRH POMC
26 gangliocytoma 10.1 CRH POMC
27 pituitary carcinoma 10.1 CRH POMC
28 acth deficiency, isolated 10.1 CRH POMC
29 nelson syndrome 10.1 CRH POMC
30 sheehan syndrome 10.1 CRH POMC
31 hypoadrenalism 10.1 CRH POMC
32 acth-secreting pituitary adenoma 10.1 CRH POMC
33 ganglioneuroma 10.1
34 fasting hypoglycemia 10.0 CRH POMC
35 renal cell carcinoma, nonpapillary 10.0
36 amenorrhea 10.0
37 achalasia-addisonianism-alacrima syndrome 10.0 MC2R POMC
38 extramedullary plasmacytoma 10.0
39 plasmacytoma 10.0
40 bronchogenic cyst 10.0
41 withdrawal disorder 10.0 CRH POMC
42 persistent fetal circulation syndrome 10.0 CRH POMC
43 thyroiditis 10.0
44 postpartum depression 10.0 CRH HSD11B1
45 hypothyroidism, congenital, nongoitrous, 4 10.0 CRH POMC
46 functioning pituitary adenoma 10.0 MEN1 POMC
47 multiple endocrine neoplasia, type i 10.0
48 lung cancer 10.0
49 hypokalemia 10.0
50 multiple endocrine neoplasia 10.0

Graphical network of the top 20 diseases related to Adrenal Adenoma:



Diseases related to Adrenal Adenoma

Symptoms & Phenotypes for Adrenal Adenoma

GenomeRNAi Phenotypes related to Adrenal Adenoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased transferrin (TF) endocytosis GR00363-A 9.65 CRH CYP11A1 CYP11B1 CYP11B2 CYP21A2 GIPR
2 Reduced mammosphere formation GR00396-S 9.17 CYP11B1 CYP21A2 GIPR KCNJ5 MC2R MEN1

MGI Mouse Phenotypes related to Adrenal Adenoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.09 CYP11A1 CYP11B1 CYP11B2 HSD11B1 KCNJ5 MC2R
2 growth/size/body region MP:0005378 10.07 CRH CYP11A1 CYP11B1 CYP11B2 CYP17A1 HSD11B1
3 behavior/neurological MP:0005386 10.06 CRH CYP11A1 CYP11B1 CYP17A1 HSD11B1 MC2R
4 endocrine/exocrine gland MP:0005379 10.06 CRH CYP11A1 CYP11B1 CYP11B2 GIPR HSD11B1
5 homeostasis/metabolism MP:0005376 10.06 CRH CYP11A1 CYP11B1 CYP11B2 CYP17A1 GIPR
6 adipose tissue MP:0005375 9.95 CRH CYP11B2 CYP17A1 HSD11B1 MC2R POMC
7 immune system MP:0005387 9.86 CRH CYP11A1 CYP11B2 HSD11B1 MC2R MEN1
8 liver/biliary system MP:0005370 9.63 CRH CYP11A1 CYP11B2 HSD11B1 MEN1 POMC
9 nervous system MP:0003631 9.56 CRH CYP11A1 CYP11B2 HSD11B1 MC2R MEN1
10 renal/urinary system MP:0005367 9.1 CRH CYP11B1 CYP11B2 CYP17A1 POMC REN

Drugs & Therapeutics for Adrenal Adenoma

Drugs for Adrenal Adenoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 81)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Racepinephrine Approved Phase 4,Phase 3,Phase 2,Not Applicable 329-65-7 838
2
Epinephrine Approved, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 51-43-4 5816
3 Neurotransmitter Agents Phase 4,Phase 3,Not Applicable
4 Anti-Asthmatic Agents Phase 4,Phase 3,Not Applicable
5 Adrenergic beta-Agonists Phase 4,Phase 3,Not Applicable
6 Respiratory System Agents Phase 4,Phase 3,Not Applicable
7 Autonomic Agents Phase 4,Phase 3,Phase 2,Not Applicable
8 Adrenergic alpha-Agonists Phase 4,Phase 3,Not Applicable
9 Mydriatics Phase 4,Phase 3,Not Applicable
10 Adrenergic Agonists Phase 4,Phase 3,Not Applicable
11 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Not Applicable
12 Adrenergic Agents Phase 4,Phase 3,Not Applicable
13 Epinephryl borate Phase 4,Phase 3,Phase 2,Not Applicable
14 Sympathomimetics Phase 4,Phase 3,Not Applicable
15 Bronchodilator Agents Phase 4,Phase 3,Not Applicable
16 Vasoconstrictor Agents Phase 4,Phase 3,Not Applicable
17
Hydrocortisone Approved, Vet_approved Phase 3,Phase 2,Not Applicable 50-23-7 5754
18
Hydrocortisone acetate Approved, Vet_approved Phase 3,Phase 2,Not Applicable 50-03-3
19
Mifepristone Approved, Investigational Phase 3 84371-65-3 55245
20
Etomidate Approved Phase 3 33125-97-2 667484 36339
21 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3,Phase 2,Not Applicable
22 Hormones Phase 3,Phase 2,Not Applicable
23 Hormone Antagonists Phase 3,Phase 2,Not Applicable
24 glucocorticoids Phase 3,Phase 2
25 Contraceptives, Oral Phase 3
26 Luteolytic Agents Phase 3
27 Contraceptive Agents Phase 3
28 beta-endorphin Phase 3
29 Contraceptives, Postcoital Phase 3
30 Melanocyte-Stimulating Hormones Phase 3
31 Hydrocortisone 17-butyrate 21-propionate Phase 3,Phase 2,Not Applicable
32 Cortisol succinate Phase 3,Phase 2,Not Applicable
33 Adrenocorticotropic Hormone Phase 3,Phase 2
34 Fluorodeoxyglucose F18 Phase 3
35 Central Nervous System Depressants Phase 3
36 Anesthetics Phase 3
37 Anesthetics, Intravenous Phase 3
38 Hypnotics and Sedatives Phase 3
39 Anesthetics, General Phase 3
40
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 2 1177-87-3
41
Dexamethasone Approved, Investigational, Vet_approved Phase 2 50-02-2 5743
42 Antineoplastic Agents, Hormonal Phase 2
43
protease inhibitors Phase 2
44 BB 1101 Phase 2
45 Antiemetics Phase 2
46 Anti-Inflammatory Agents Phase 2,Not Applicable
47 Gastrointestinal Agents Phase 2
48 HIV Protease Inhibitors Phase 2
49
Dopamine Approved 51-61-6, 62-31-7 681
50
Ethanol Approved 64-17-5 702

Interventional clinical trials:

(show all 34)
# Name Status NCT ID Phase Drugs
1 Influence of Synacthen Infusion on the Results of Adrenal Venous Sampling in Patient With Primary Aldosteronism Unknown status NCT02127840 Phase 4 Synacthen infusion during adrenal venous sampling
2 An Extension Study of CORLUX in the Treatment of Endogenous Cushing's Syndrome Completed NCT00936741 Phase 3 mifepristone
3 A Study of the Efficacy and Safety of CORLUX in the Treatment of Endogenous Cushing's Syndrome Completed NCT00569582 Phase 3 mifepristone
4 Combined FDG-PET and 123I-Iodometomidate Imaging for Adrenal Neoplasia Recruiting NCT02010957 Phase 3
5 A Study of the Efficacy and Safety of Relacorilant Recruiting NCT03697109 Phase 3 Relacorilant
6 Medical Safety Follow-up Study for Patients Who Received More Than 28 Days of Total Exposure to BGG492 Completed NCT02150213 Phase 2 BGG492
7 Study of Efficacy and Safety of Osilodrostat in Cushing's Syndrome Completed NCT02468193 Phase 2 Osilodrostat
8 Study to Evaluate CORT125134 in Patients With Cushing's Syndrome Completed NCT02804750 Phase 2 CORT125134
9 Extension Study to Evaluate the Safety and Clinical Benefit of Long-Term Use of Relacorilant in Patients With Cushing Syndrome Recruiting NCT03604198 Phase 2 relacorilant
10 Study of Adrenalectomy Versus Observation for Subclinical Hypercortisolism Terminated NCT02001051 Phase 2
11 Long-term Beneficial Metabolic Effects of Adrenalectomy in Subclinical Cushing's Syndrome of Adrenal Incidentaloma Unknown status NCT01382420 Not Applicable
12 Does Serum-DXM Increase Diagnostic Accuracy of the Overnight DXM Suppression Test in the Work-up of Cushing's Syndrome? Unknown status NCT01504555
13 D2 Dopamine Receptor on Human Aldosterone-Producing Adenoma and Its Role in Aldosterone Secretion and Cell Proliferation Unknown status NCT00173446
14 Cardiovascular Risk in Patients With Non-Functional Adrenal Incidentaloma Completed NCT00768365
15 Rare Cystic Benign Adrenal Incidentalomas Completed NCT03739918
16 Comparison Between Posterior Retroperitoneoscopic Adrenalectomy and Laparoscopic Adrenalectomy Completed NCT01676025 Not Applicable
17 Surgery of Subclinical Cortisol Secreting Adrenal Incidentalomas Recruiting NCT02364089 Not Applicable Standardized medical treatment of hypertension by SAHR
18 Radiofrequency Ablation for Aldosterone-producting Adenoma in Patients With Primary Aldosteronism Recruiting NCT02756754 Not Applicable
19 Radiofrequency Endoscopic Ablation With Ultrasound Guidance: a Non-surgical Treatment for Aldosterone-producing Adenomas Recruiting NCT03405025 Not Applicable
20 Structured Evaluation of adRENal Tumors Discovered Incidentally - Prospectively Investigating the Testing Yield Recruiting NCT02324647
21 Effect of Chronic Catecholamine Overproduction on Brown Adipose Tissue Recruiting NCT01949714
22 Adrenalectomy Versus Follow-up in Patients With Subclinical Cushings Syndrome Recruiting NCT01246739 Not Applicable
23 Quality of Life, Fatigue and Cognitive, Affective and Emotional Dysfunction in Patients With Cushing's Syndrome Recruiting NCT03211624
24 Clinical and Molecular Characteristics of Primary Aldosteronism in Blacks Recruiting NCT03374215
25 Glucose Metabolism in Subjects With Aldosterone-Producing Adenomas Recruiting NCT02362308 Not Applicable mineralocorticoid receptor antagonist
26 Study of Adrenal Gland Tumors Recruiting NCT00005927
27 Renal Sympathetic Denervation From The Adventitia on Hypertension Recruiting NCT02642445 Not Applicable
28 Prospective Study Assessing Blood Pressure and Other Outcomes Post-treatment in Patients With Primary Aldosteronism Recruiting NCT03174847 Mineralocorticoid Receptor Antagonists
29 Laparoscopic Adrenalectomy Versus Radiofrequency Ablation Active, not recruiting NCT02030587 Not Applicable
30 Expression of Different Proliferation Biomarkers in Adreno-cortical Tumors Active, not recruiting NCT02747355
31 A Prospective Cohort Study for Patients With Adrenal Diseases Not yet recruiting NCT03474237
32 Rapid Cortisol Assay in Adrenal Vein Sampling Not yet recruiting NCT03449797 Not Applicable
33 Macrolides for KCNJ5 - Mutated Aldosterone-Producing Adenoma (MAPA) Not yet recruiting NCT03414918 Not Applicable Clarithromycin
34 A Study to Confirm Recurrent or Persistent Cushing's Syndrome in Patients With Signs or Symptoms of Hypercortisolemia Terminated NCT00796783 Cushing's syndrome confirmation

Search NIH Clinical Center for Adrenal Adenoma

Genetic Tests for Adrenal Adenoma

Anatomical Context for Adrenal Adenoma

MalaCards organs/tissues related to Adrenal Adenoma:

41
Adrenal Gland, Pituitary, Prostate, Thyroid, Lung, Kidney, Liver

Publications for Adrenal Adenoma

Articles related to Adrenal Adenoma:

(show top 50) (show all 332)
# Title Authors Year
1
Lipid-poor adrenal adenoma versus metastasis in lung cancer: Diagnosis by "comparative enhancement" at multiphasic MR imaging. ( 29970786 )
2018
2
Visfatin levels in hormonally inactive adrenal adenoma and their association with metabolic parameters ( 29914251 )
2018
3
Secreting ectopic adrenal adenoma: A rare condition to be aware of. ( 29525561 )
2018
4
A black adrenal adenoma with high FDG uptake on PET/CT scan in a patient with esophageal carcinoma: A case report. ( 29499515 )
2018
5
Clinical Characteristics of Aldosterone- and Cortisol-Coproducing Adrenal Adenoma in Primary Aldosteronism. ( 29770148 )
2018
6
Adrenal incidentaloma: machine learning-based quantitative texture analysis of unenhanced CT can effectively differentiate sPHEO from lipid-poor adrenal adenoma. ( 30310515 )
2018
7
PREOPERATIVE TREATMENT WITH METYRAPONE IN PATIENTS WITH CUSHING'S SYNDROME DUE TO ADRENAL ADENOMA. ( 30352400 )
2018
8
Impact of body mass index on CT attenuation of adrenal adenoma. ( 30396653 )
2018
9
Relationship Among Tumor Attenuation Value of Pre-contrast Computed Tomography (CT), Washout Rate and Constituent Cells in Adrenal Adenoma: Proposition of a New Approach for Diagnosing Adrenal Adenoma on Dynamic CT. ( 30061247 )
2018
10
Reninoma coexisting with adrenal adenoma during pregnancy: A case report. ( 28521424 )
2017
11
An exceedingly rare adrenal collision tumor: adrenal adenoma-metastatic breast cancer-myelolipoma. ( 29046752 )
2017
12
Effects of Mifepristone on Nonalcoholic Fatty Liver Disease in a Patient with a Cortisol-Secreting Adrenal Adenoma. ( 29348947 )
2017
13
Diagnostic accuracy of virtual non-contrast enhanced dual-energy CT for diagnosis of adrenal adenoma: A systematic review and meta-analysis. ( 28289937 )
2017
14
Integrated Imaging Characterization of Adrenal Adenoma: False-Positive Metaiodobenzylguanidine (MIBG) Findings of Adrenal Scintigraphy. ( 29662567 )
2017
15
Comparison of Quantitative MRI and CT Washout Analysis for Differentiation of Adrenal Pheochromocytoma From Adrenal Adenoma. ( 27011100 )
2016
16
ADC histogram analysis for adrenal tumor histogram analysis of apparent diffusion coefficient in differentiating adrenal adenoma from pheochromocytoma. ( 27571307 )
2016
17
Cellular pathophysiology of an adrenal adenoma-associated mutant of the plasma membrane Ca(2+)-ATPase ATP2B3. ( 27035656 )
2016
18
Characterization of Adrenal Adenoma by Gaussian Model-Based Algorithm. ( 27020253 )
2016
19
Increased 3I^-hydroxysteroid dehydrogenase 2 and 17I+-hydroxylase activities in a virilized adolescent female with adrenal adenoma: A case report. ( 26893641 )
2016
20
Adrenal Adenoma and Pheochromocytoma: Comparison of Multidetector CT Venous Enhancement Levels and Washout Characteristics. ( 26978001 )
2016
21
cAMP signaling in cortisol-producing adrenal adenoma. ( 26139209 )
2015
22
Robotic-assisted laparoscopic adrenalectomy for an adrenal adenoma. ( 26425459 )
2015
23
Black adrenal adenoma causing Cushing's syndrome: 40 years ago and today. ( 26088906 )
2015
24
The Importance of Exclusion of Obstructive Sleep Apnea During Screening for Adrenal Adenoma and Diagnosis of Pheochromocytoma. ( 26904704 )
2015
25
Rare anaphylaxis and functioning adrenal adenoma. ( 25583253 )
2015
26
A functioning adrenal adenoma and pheochromocytoma in the same adrenal gland: two discrete adrenal incidentalomas. ( 25589844 )
2015
27
Gallium-68 PSMA uptake in adrenal adenoma. ( 26394552 )
2015
28
Poor head growth as a presenting sign of a cortisol-secreting adrenal adenoma in a 2-year-old boy. ( 25575422 )
2015
29
CT sensitivity for adrenal adenoma according to lesion size. ( 26254908 )
2015
30
Bilateral Adrenal Adenoma Presented As Multiple Metatarsal And Phalangeal Fractures. ( 27299107 )
2015
31
A patient with pemphigus foliaceus and myasthenia gravis treated by a cortisol-secreting adrenal adenoma. ( 24931108 )
2015
32
Spironolactone interference in the immunoassay of androstenedione in a patient with a cortisol secreting adrenal adenoma. ( 24612380 )
2014
33
CT sensitivities for large (a8Y3A cm) adrenal adenoma and cortical carcinoma. ( 25060750 )
2014
34
Posterior gastric diverticulum mimicking adrenal adenoma on imaging. ( 25535229 )
2014
35
Two rare cases of familial (mother and daughter) adrenocorticotropic hormone-independent Cushing's syndrome due to adrenal adenoma, as well as the asynchronous development of another contralateral adrenal adenoma in the mother. ( 24785891 )
2014
36
Effectiveness of partial adrenalectomy for concomitant hypertension in patients with nonfunctional adrenal adenoma. ( 25305227 )
2014
37
Periodic drop thumb, hypokalemia and adrenal adenoma. ( 23899956 )
2014
38
Open-angle glaucoma secondary to Cushing syndrome related to an adrenal adenoma: Case report. ( 25264153 )
2014
39
Characterization of lipid-poor adrenal adenoma: chemical-shift MRI and washout CT. ( 24758658 )
2014
40
Spontaneous rupture of an adrenal adenoma managed by laparoscopic adrenalectomy: a case report. ( 24701740 )
2014
41
Imaging and management of a small cell lung cancer metastasis/adrenal adenoma collision tumor: a case report and review of the literature. ( 24571800 )
2014
42
Aldosterone- and cortisol-co-producing adrenal adenoma without clinical features of Cushing syndrome. ( 25228847 )
2014
43
Giant non-functional adrenal adenoma: A case report. ( 23255953 )
2013
44
Differentiation of adrenal tumors in patients with hepatocellular carcinoma: adrenal adenoma versus metastasis. ( 23478006 )
2013
45
Reversibility of myocardial hypertrophy 8 years after adrenal adenoma excision and drugs and alcohol addiction withdrawal. ( 23674558 )
2013
46
Adrenal adenoma and metastasis from clear cell renal cell carcinoma: can they be differentiated using standard MR techniques? ( 24252816 )
2013
47
Dual-energy CT: clinical application in differentiating an adrenal adenoma from a metastasis. ( 23969261 )
2013
48
Dysplastic extramedullary haematopoeisis with ringed sideroblasts mimicking adrenal adenoma. ( 23944958 )
2013
49
Endogenous Cushing's Syndrome with Precocious Puberty in an 8-Year-Old Boy due to a Large Unilateral Adrenal Adenoma. ( 23533838 )
2013
50
Pure androgen-secreting adrenal adenoma associated with resistant hypertension. ( 23819074 )
2013

Variations for Adrenal Adenoma

ClinVar genetic disease variations for Adrenal Adenoma:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 MEN1 NM_000244.3(MEN1): c.1669A> T (p.Thr557Ser) single nucleotide variant Pathogenic rs121913035 GRCh37 Chromosome 11, 64571985: 64571985
2 MEN1 NM_000244.3(MEN1): c.1669A> T (p.Thr557Ser) single nucleotide variant Pathogenic rs121913035 GRCh38 Chromosome 11, 64804513: 64804513

Cosmic variations for Adrenal Adenoma:

9 (show top 50) (show all 80)
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM11552 TP53 adrenal gland,adrenal gland,adrenal cortical adenoma,NS c.775G>T p.D259Y 17:7674188-7674188 21
2 COSM43678 TP53 adrenal gland,adrenal gland,adrenal cortical adenoma,NS c.305C>T p.T102I 17:7676064-7676064 21
3 COSM45444 TP53 adrenal gland,adrenal gland,adrenal cortical adenoma,NS c.587G>T p.R196L 17:7674944-7674944 21
4 COSM43555 TP53 adrenal gland,adrenal gland,adrenal cortical adenoma,NS c.736A>G p.M246V 17:7674227-7674227 21
5 COSM1367296 RB1 adrenal gland,adrenal gland,adrenal cortical adenoma,NS c.2094G>T p.R698S 13:48459821-48459821 21
6 COSM225014 RB1 adrenal gland,adrenal gland,adrenal cortical adenoma,NS c.1960G>A p.V654M 13:48456349-48456349 21
7 COSM26707 PRKAR1A adrenal gland,adrenal gland,adrenal cortical adenoma,NS c.664A>G p.K222E 17:68525868-68525868 21
8 COSM26708 PRKAR1A adrenal gland,adrenal gland,adrenal cortical adenoma,NS c.892-1G>A p.? 17:68529919-68529919 21
9 COSM4167506 PRKACA adrenal gland,adrenal gland,adrenal cortical adenoma,NS c.617T>G p.L206R 19:14097604-14097604 21
10 COSM5885970 PRKACA adrenal gland,adrenal gland,adrenal cortical adenoma,NS c.262C>G p.H88D 19:14102890-14102890 21
11 COSM6944239 PLCG2 adrenal gland,adrenal gland,adrenal cortical adenoma,NS c.615C>A p.F205L 16:81870902-81870902 21
12 COSM6944237 NUP93 adrenal gland,adrenal gland,adrenal cortical adenoma,NS c.2172G>T p.Q724H 16:56839556-56839556 21
13 COSM584 NRAS adrenal gland,adrenal gland,adrenal cortical adenoma,NS c.182A>G p.Q61R 1:114713908-114713908 21
14 COSM6944241 NF1 adrenal gland,adrenal gland,adrenal cortical adenoma,NS c.3265G>T p.E1089* 17:31232140-31232140 21
15 COSM22568 MEN1 adrenal gland,adrenal gland,adrenal cortical adenoma,NS c.325G>T p.E109* 11:64809785-64809785 21
16 COSM23025 MEN1 adrenal gland,adrenal gland,adrenal cortical adenoma,NS c.1654A>T p.T552S 11:64804513-64804513 21
17 COSM6944234 KMT2A adrenal gland,adrenal gland,adrenal cortical adenoma,NS c.8408C>A p.S2803* 11:118504309-118504309 21
18 COSM1684718 KCNJ5 adrenal gland,adrenal gland,adrenal cortical adenoma,NS c.503T>G p.L168R 11:128911776-128911776 21
19 COSM1684717 KCNJ5 adrenal gland,adrenal gland,adrenal cortical adenoma,NS c.451G>A p.G151R 11:128911724-128911724 21
20 COSM1684720 KCNJ5 adrenal gland,adrenal gland,adrenal cortical adenoma,NS c.451G>C p.G151R 11:128911724-128911724 21
21 COSM4745630 KCNJ5 adrenal gland,adrenal gland,adrenal cortical adenoma,NS c.343C>T p.R115W 11:128911616-128911616 21
22 COSM1732665 KCNJ5 adrenal gland,adrenal gland,adrenal cortical adenoma,NS c.376T>C p.W126R 11:128911649-128911649 21
23 COSM1717390 KCNJ5 adrenal gland,adrenal gland,adrenal cortical adenoma,NS c.433G>C p.E145Q 11:128911706-128911706 21
24 COSM1684719 KCNJ5 adrenal gland,adrenal gland,adrenal cortical adenoma,NS c.472A>G p.T158A 11:128911745-128911745 21
25 COSM4745631 KCNJ5 adrenal gland,adrenal gland,adrenal cortical adenoma,NS c.737A>G p.E246G 11:128912010-128912010 21
26 COSM5546565 KCNJ5 adrenal gland,adrenal gland,adrenal cortical adenoma,NS c.439G>C p.E147Q 11:128911712-128911712 21
27 COSM5990170 KCNJ5 adrenal gland,adrenal gland,adrenal cortical adenoma,NS c.461T>G p.F154C 11:128911734-128911734 21
28 COSM27887 GNAS adrenal gland,adrenal gland,adrenal cortical adenoma,NS c.601C>T p.R201C 20:58909365-58909365 21
29 COSM27899 GNAS adrenal gland,adrenal gland,adrenal cortical adenoma,NS c.601C>A p.R201S 20:58909365-58909365 21
30 COSM27895 GNAS adrenal gland,adrenal gland,adrenal cortical adenoma,NS c.602G>A p.R201H 20:58909366-58909366 21
31 COSM4962873 GNAS adrenal gland,adrenal gland,adrenal cortical adenoma,NS c.679C>G p.Q227E 20:58909540-58909540 21
32 COSM5663 CTNNB1 adrenal gland,adrenal gland,adrenal cortical adenoma,NS c.133T>C p.S45P 3:41224645-41224645 21
33 COSM5686 CTNNB1 adrenal gland,adrenal gland,adrenal cortical adenoma,NS c.100G>A p.G34R 3:41224612-41224612 21
34 COSM5692 CTNNB1 adrenal gland,adrenal gland,adrenal cortical adenoma,NS c.134C>A p.S45Y 3:41224646-41224646 21
35 COSM5667 CTNNB1 adrenal gland,adrenal gland,adrenal cortical adenoma,NS c.134C>T p.S45F 3:41224646-41224646 21
36 COSM5689 CTNNB1 adrenal gland,adrenal gland,adrenal cortical adenoma,NS c.134C>G p.S45C 3:41224646-41224646 21
37 COSM17661 CTNNB1 adrenal gland,adrenal gland,adrenal cortical adenoma,NS c.130C>G p.P44A 3:41224642-41224642 21
38 COSM5678 CTNNB1 adrenal gland,adrenal gland,adrenal cortical adenoma,NS c.107A>C p.H36P 3:41224619-41224619 21
39 COSM5664 CTNNB1 adrenal gland,adrenal gland,adrenal cortical adenoma,NS c.121A>G p.T41A 3:41224633-41224633 21
40 COSM5679 CTNNB1 adrenal gland,adrenal gland,adrenal cortical adenoma,NS c.110C>G p.S37C 3:41224622-41224622 21
41 COSM1423013 CTNNB1 adrenal gland,adrenal gland,adrenal cortical adenoma,NS c.137T>C p.L46P 3:41224649-41224649 21
42 COSM5988492 CTNNB1 adrenal gland,adrenal gland,adrenal cortical adenoma,NS c.101G>C p.G34A 3:41224613-41224613 21
43 COSM5681 CTNNB1 adrenal gland,adrenal gland,adrenal cortical adenoma,NS c.95A>G p.D32G 3:41224607-41224607 21
44 COSM5677 CTNNB1 adrenal gland,adrenal gland,adrenal cortical adenoma,NS c.98C>G p.S33C 3:41224610-41224610 21
45 COSM6944226 CDC73 adrenal gland,adrenal gland,adrenal cortical adenoma,NS c.790G>T p.A264S 1:193147927-193147927 21
46 COSM1717762 CACNA1D adrenal gland,adrenal gland,adrenal cortical adenoma,NS c.776T>A p.V259D 3:53665669-53665669 21
47 COSM1738073 CACNA1D adrenal gland,adrenal gland,adrenal cortical adenoma,NS c.1207G>C p.G403R 3:53673803-53673803 21
48 COSM1738072 CACNA1D adrenal gland,adrenal gland,adrenal cortical adenoma,NS c.2301C>G p.F767L 3:53730461-53730461 21
49 COSM4745611 CACNA1D adrenal gland,adrenal gland,adrenal cortical adenoma,NS c.2024T>C p.L675P 3:53723863-53723863 21
50 COSM1717766 CACNA1D adrenal gland,adrenal gland,adrenal cortical adenoma,NS c.4112C>G p.P1371R 3:53772840-53772840 21

Expression for Adrenal Adenoma

Search GEO for disease gene expression data for Adrenal Adenoma.

Pathways for Adrenal Adenoma

Pathways related to Adrenal Adenoma according to GeneCards Suite gene sharing:

(show all 11)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.91 CYP11A1 CYP11B1 CYP11B2 CYP17A1 CYP21A2 POMC
2
Show member pathways
12.53 CYP11A1 CYP11B1 CYP11B2 CYP17A1 CYP21A2 KCNJ5
3
Show member pathways
11.96 CRH CYP11A1 CYP11B1 CYP17A1 CYP21A2 MC2R
4 11.87 CRH GIPR MC2R POMC
5 11.73 CRH CYP11A1 CYP11B1 CYP21A2 POMC
6
Show member pathways
11.62 CYP11A1 MC2R POMC
7
Show member pathways
11.45 CYP11A1 CYP11B1 CYP11B2 CYP17A1 CYP21A2 HSD11B1
8
Show member pathways
11.11 CYP11A1 CYP11B1 CYP11B2 CYP17A1 CYP21A2 HSD11B1
9 10.97 CYP11A1 HSD11B1
10
Show member pathways
10.94 CYP11B1 CYP11B2 CYP17A1 CYP21A2
11 10.3 CRH POMC

GO Terms for Adrenal Adenoma

Biological processes related to Adrenal Adenoma according to GeneCards Suite gene sharing:

(show all 16)
# Name GO ID Score Top Affiliating Genes
1 oxidation-reduction process GO:0055114 9.88 CYP11A1 CYP11B1 CYP11B2 CYP17A1 CYP21A2 HSD11B1
2 lipid metabolic process GO:0006629 9.86 CYP11A1 CYP11B1 CYP11B2 HSD11B1
3 cholesterol metabolic process GO:0008203 9.69 CYP11A1 CYP11B1 CYP11B2
4 regulation of blood pressure GO:0008217 9.67 CYP11B1 POMC REN
5 steroid biosynthetic process GO:0006694 9.65 CYP11A1 CYP11B1 CYP11B2 CYP17A1 CYP21A2
6 cellular response to peptide hormone stimulus GO:0071375 9.62 CYP11A1 CYP11B1 CYP11B2 MEN1
7 response to immobilization stress GO:0035902 9.55 CRH REN
8 sterol metabolic process GO:0016125 9.55 CYP11A1 CYP11B1 CYP11B2 CYP17A1 CYP21A2
9 positive regulation of cAMP-mediated signaling GO:0043950 9.54 CRH GIPR
10 C21-steroid hormone biosynthetic process GO:0006700 9.54 CYP11A1 CYP11B1 CYP11B2
11 cellular response to potassium ion GO:0035865 9.52 CYP11B1 CYP11B2
12 steroid metabolic process GO:0008202 9.5 CRH CYP11A1 CYP11B1 CYP11B2 CYP17A1 CYP21A2
13 mineralocorticoid biosynthetic process GO:0006705 9.48 CYP11B2 CYP21A2
14 aldosterone biosynthetic process GO:0032342 9.46 CYP11B1 CYP11B2
15 cortisol biosynthetic process GO:0034651 9.43 CYP11B1 CYP11B2
16 glucocorticoid biosynthetic process GO:0006704 9.17 CRH CYP11A1 CYP11B1 CYP11B2 CYP17A1 CYP21A2

Molecular functions related to Adrenal Adenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 oxidoreductase activity GO:0016491 9.73 CYP11A1 CYP11B1 CYP11B2 CYP17A1 CYP21A2 HSD11B1
2 heme binding GO:0020037 9.55 CYP11A1 CYP11B1 CYP11B2 CYP17A1 CYP21A2
3 steroid binding GO:0005496 9.43 CYP21A2 HSD11B1
4 steroid hydroxylase activity GO:0008395 9.4 CYP11B2 CYP21A2
5 corticosterone 18-monooxygenase activity GO:0047783 9.37 CYP11B1 CYP11B2
6 iron ion binding GO:0005506 9.35 CYP11A1 CYP11B1 CYP11B2 CYP17A1 CYP21A2
7 steroid 11-beta-monooxygenase activity GO:0004507 9.32 CYP11B1 CYP11B2
8 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen GO:0016705 9.02 CYP11A1 CYP11B1 CYP11B2 CYP17A1 CYP21A2

Sources for Adrenal Adenoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
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62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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