MCID: ADR008
MIFTS: 51

Adrenal Adenoma

Categories: Cancer diseases, Endocrine diseases, Rare diseases

Aliases & Classifications for Adrenal Adenoma

MalaCards integrated aliases for Adrenal Adenoma:

Name: Adrenal Adenoma 12 54 56 15
Adenoma of the Adrenal Gland 12 77 54 6
Adrenal Cortical Adenoma 54 74
Adrenal Incidentaloma 54 74
Adrenocortical Adenoma 54

Classifications:



External Ids:

Disease Ontology 12 DOID:656

Summaries for Adrenal Adenoma

NIH Rare Diseases : 54 Adenomas of the adrenal gland are non-cancerous (benign) tumors on the adrenal gland. Most do not cause any signs or symptoms and rarely require treatment. However, some may become "active" or "functioning" which means they produce hormones, often in excess of what the adrenal glands typically produce. High levels of these hormones can lead to complications, including primary aldosteronism, Cushing's syndrome and other medical conditions. Functioning adrenal adenomas may be treated with surgery and/or medications.

MalaCards based summary : Adrenal Adenoma, also known as adenoma of the adrenal gland, is related to adenoma and adrenal cortical adenoma. An important gene associated with Adrenal Adenoma is MEN1 (Menin 1), and among its related pathways/superpathways are Cytochrome P450 - arranged by substrate type and Aldosterone synthesis and secretion. The drugs Racepinephrine and Epinephrine have been mentioned in the context of this disorder. Affiliated tissues include adrenal gland, pituitary and thyroid, and related phenotypes are Increased transferrin (TF) endocytosis and Reduced mammosphere formation

Disease Ontology : 12 An endocrine organ benign neoplasm that is a benign tumor of the glandular type (adenoma) in the adrenal gland.

Wikipedia : 77 An adenoma is a benign tumor of epithelial tissue with glandular origin, glandular characteristics, or... more...

Related Diseases for Adrenal Adenoma

Diseases related to Adrenal Adenoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 191)
# Related Disease Score Top Affiliating Genes
1 adenoma 31.0 CYP11B2 CYP21A2 KCNJ5 MEN1 POMC
2 adrenal cortical adenoma 30.6 CYP11A1 CYP11B1 CYP17A1 CYP21A2 GIPR MC2R
3 gangliocytoma 30.3 CRH POMC
4 aldosterone-producing adenoma 30.2 CYP11B2 CYP21A2 KCNJ5
5 leydig cell tumor 29.9 CYP11A1 CYP17A1 CYP21A2
6 hyperandrogenism 29.8 CYP17A1 CYP21A2 HSD11B1 POMC
7 adrenal carcinoma 29.5 CRH CYP11A1 CYP11B1 CYP11B2 CYP17A1 CYP21A2
8 pituitary gland disease 29.5 CRH MEN1 POMC
9 pheochromocytoma 29.4 CRH MEN1 POMC REN
10 hypertension, essential 29.1 CYP11B1 CYP11B2 MEN1 REN
11 hypoadrenocorticism, familial 28.9 CRH CYP11A1 CYP21A2 MC2R POMC
12 adrenocortical carcinoma, hereditary 28.2 CRH CYP11A1 CYP11B1 CYP11B2 CYP17A1 CYP21A2
13 lipoid congenital adrenal hyperplasia 28.1 CYP11A1 CYP11B1 CYP11B2 CYP17A1 CYP21A2 MC2R
14 conn's syndrome 27.6 CRH CYP11A1 CYP11B1 CYP11B2 CYP17A1 CYP21A2
15 primary pigmented nodular adrenocortical disease 11.5
16 hyperaldosteronism, familial, type ii 11.3
17 acth-independent macronodular adrenal hyperplasia 11.2
18 transsexualism 10.3 CYP17A1 CYP21A2
19 classic congenital adrenal hyperplasia due to 21-hydroxylase deficiency 10.3 CYP21A2 POMC
20 antley-bixler syndrome 10.2 CYP17A1 CYP21A2
21 adrenal gland pheochromocytoma 10.2
22 autoimmune polyendocrine syndrome, type i, with or without reversible metaphyseal dysplasia 10.2 CYP11A1 CYP17A1 CYP21A2
23 cytochrome p450 oxidoreductase deficiency 10.1 CYP17A1 CYP21A2 POMC
24 allergic encephalomyelitis 10.1 CRH POMC
25 polycystic ovary syndrome 10.1 CYP11A1 CYP17A1 CYP21A2
26 glucocorticoid deficiency 1 10.1 MC2R POMC
27 hypothalamic disease 10.1 CRH POMC
28 pituitary carcinoma 10.1 CRH POMC
29 acth deficiency, isolated 10.1 CRH POMC
30 nelson syndrome 10.1 CRH POMC
31 sheehan syndrome 10.1 CRH POMC
32 hypoadrenalism 10.1 CRH POMC
33 acth-secreting pituitary adenoma 10.1 CRH POMC
34 fasting hypoglycemia 10.1 CRH POMC
35 achalasia-addisonianism-alacrima syndrome 10.1 MC2R POMC
36 adrenal cortical carcinoma 10.1
37 ganglioneuroma 10.1
38 renal cell carcinoma, nonpapillary 10.1
39 amenorrhea 10.1
40 human immunodeficiency virus type 1 10.1
41 leiomyoma 10.1
42 neurilemmoma 10.1
43 extramedullary plasmacytoma 10.1
44 plasmacytoma 10.1
45 bronchogenic cyst 10.1
46 withdrawal disorder 10.0 CRH POMC
47 persistent fetal circulation syndrome 10.0 CRH POMC
48 oncocytoma 10.0
49 thyroid cancer 10.0
50 thyroiditis 10.0

Graphical network of the top 20 diseases related to Adrenal Adenoma:



Diseases related to Adrenal Adenoma

Symptoms & Phenotypes for Adrenal Adenoma

GenomeRNAi Phenotypes related to Adrenal Adenoma according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased transferrin (TF) endocytosis GR00363-A 9.65 CRH CYP11A1 CYP11B1 CYP11B2 CYP21A2 GIPR
2 Reduced mammosphere formation GR00396-S 9.17 CYP11B1 CYP21A2 GIPR KCNJ5 MC2R MEN1

MGI Mouse Phenotypes related to Adrenal Adenoma:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.09 CYP11A1 CYP11B1 CYP11B2 HSD11B1 KCNJ5 MC2R
2 growth/size/body region MP:0005378 10.07 CRH CYP11A1 CYP11B1 CYP11B2 CYP17A1 HSD11B1
3 behavior/neurological MP:0005386 10.06 CRH CYP11A1 CYP11B1 CYP17A1 HSD11B1 MC2R
4 endocrine/exocrine gland MP:0005379 10.06 CRH CYP11A1 CYP11B1 CYP11B2 GIPR HSD11B1
5 homeostasis/metabolism MP:0005376 10.06 CRH CYP11A1 CYP11B1 CYP11B2 CYP17A1 GIPR
6 adipose tissue MP:0005375 9.95 CRH CYP11B2 CYP17A1 HSD11B1 MC2R POMC
7 immune system MP:0005387 9.86 CRH CYP11A1 CYP11B2 HSD11B1 MC2R MEN1
8 liver/biliary system MP:0005370 9.63 CRH CYP11A1 CYP11B2 HSD11B1 MEN1 POMC
9 nervous system MP:0003631 9.56 CRH CYP11A1 CYP11B2 HSD11B1 MC2R MEN1
10 renal/urinary system MP:0005367 9.02 CRH CYP11B1 CYP11B2 POMC REN

Drugs & Therapeutics for Adrenal Adenoma

Drugs for Adrenal Adenoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 82)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Racepinephrine Approved Phase 4,Phase 3,Phase 2,Not Applicable 329-65-7 838
2
Epinephrine Approved, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 51-43-4 5816
3 Mydriatics Phase 4,Phase 3,Not Applicable
4 Adrenergic beta-Agonists Phase 4,Phase 3,Not Applicable
5 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Not Applicable
6 Adrenergic Agonists Phase 4,Phase 3,Not Applicable
7 Vasoconstrictor Agents Phase 4,Phase 3,Not Applicable
8 Anti-Asthmatic Agents Phase 4,Phase 3,Not Applicable
9 Autonomic Agents Phase 4,Phase 3,Phase 2,Not Applicable
10 Neurotransmitter Agents Phase 4,Phase 3,Not Applicable
11 Sympathomimetics Phase 4,Phase 3,Not Applicable
12 Adrenergic alpha-Agonists Phase 4,Phase 3,Not Applicable
13 Epinephryl borate Phase 4,Phase 3,Phase 2,Not Applicable
14 Bronchodilator Agents Phase 4,Phase 3,Not Applicable
15 Adrenergic Agents Phase 4,Phase 3,Not Applicable
16 Respiratory System Agents Phase 4,Phase 3,Not Applicable
17
Hydrocortisone Approved, Vet_approved Phase 3,Phase 2,Not Applicable 50-23-7 5754
18
Hydrocortisone acetate Approved, Vet_approved Phase 3,Phase 2,Not Applicable 50-03-3
19
Mifepristone Approved, Investigational Phase 3 84371-65-3 55245
20
Etomidate Approved Phase 3 33125-97-2 667484 36339
21 Hormone Antagonists Phase 3,Phase 2,Not Applicable
22 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3,Phase 2,Not Applicable
23 Hormones Phase 3,Phase 2,Not Applicable
24 glucocorticoids Phase 3,Phase 2
25 Melanocyte-Stimulating Hormones Phase 3
26 Luteolytic Agents Phase 3
27 Hydrocortisone hemisuccinate Phase 3,Phase 2,Not Applicable
28 Adrenocorticotropic Hormone Phase 3,Phase 2
29 beta-endorphin Phase 3
30 Contraceptives, Postcoital Phase 3
31 Contraceptives, Oral Phase 3
32 Contraceptive Agents Phase 3
33 Hydrocortisone 17-butyrate 21-propionate Phase 3,Phase 2,Not Applicable
34 Anesthetics, General Phase 3
35 Hypnotics and Sedatives Phase 3
36 Anesthetics Phase 3
37 Anesthetics, Intravenous Phase 3
38 Central Nervous System Depressants Phase 3
39 Fluorodeoxyglucose F18 Phase 3
40
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 2 1177-87-3
41
Dexamethasone Approved, Investigational, Vet_approved Phase 2 50-02-2 5743
42 Antiemetics Phase 2
43 Antineoplastic Agents, Hormonal Phase 2
44 Gastrointestinal Agents Phase 2
45 BB 1101 Phase 2
46
protease inhibitors Phase 2
47 Anti-Inflammatory Agents Phase 2,Not Applicable
48 HIV Protease Inhibitors Phase 2
49
Dopamine Approved 62-31-7, 51-61-6 681
50
Ethanol Approved 64-17-5 702

Interventional clinical trials:

(show all 36)
# Name Status NCT ID Phase Drugs
1 Influence of Synacthen Infusion on the Results of Adrenal Venous Sampling in Patient With Primary Aldosteronism Unknown status NCT02127840 Phase 4 Synacthen infusion during adrenal venous sampling
2 An Extension Study of CORLUX in the Treatment of Endogenous Cushing's Syndrome Completed NCT00936741 Phase 3 mifepristone
3 A Study of the Efficacy and Safety of CORLUX in the Treatment of Endogenous Cushing's Syndrome Completed NCT00569582 Phase 3 mifepristone
4 Combined FDG-PET and 123I-Iodometomidate Imaging for Adrenal Neoplasia Recruiting NCT02010957 Phase 3
5 A Study of the Efficacy and Safety of Relacorilant in Patients With Endogenous Cushing Syndrome Recruiting NCT03697109 Phase 3 Relacorilant
6 Medical Safety Follow-up Study for Patients Who Received More Than 28 Days of Total Exposure to BGG492 Completed NCT02150213 Phase 2 BGG492
7 Study of Efficacy and Safety of Osilodrostat in Cushing's Syndrome Completed NCT02468193 Phase 2 Osilodrostat
8 Study to Evaluate CORT125134 in Patients With Cushing's Syndrome Completed NCT02804750 Phase 2 CORT125134
9 Extension Study to Evaluate the Safety and Clinical Benefit of Long-Term Use of Relacorilant in Patients With Cushing Syndrome Recruiting NCT03604198 Phase 2 relacorilant
10 Study of Adrenalectomy Versus Observation for Subclinical Hypercortisolism Terminated NCT02001051 Phase 2
11 Laparoscopic Adrenalectomy Versus Radiofrequency Ablation Unknown status NCT02030587 Not Applicable
12 Does Serum-DXM Increase Diagnostic Accuracy of the Overnight DXM Suppression Test in the Work-up of Cushing's Syndrome? Unknown status NCT01504555
13 D2 Dopamine Receptor on Human Aldosterone-Producing Adenoma and Its Role in Aldosterone Secretion and Cell Proliferation Unknown status NCT00173446
14 Cardiovascular Risk in Patients With Non-Functional Adrenal Incidentaloma Completed NCT00768365
15 Rare Cystic Benign Adrenal Incidentalomas Completed NCT03739918
16 Laparoscopic Adrenalectomy for Large Adrenal Tumors. Completed NCT03830593
17 Comparison Between Posterior Retroperitoneoscopic Adrenalectomy and Laparoscopic Adrenalectomy Completed NCT01676025 Not Applicable
18 Surgery of Subclinical Cortisol Secreting Adrenal Incidentalomas Recruiting NCT02364089 Not Applicable Standardized medical treatment of hypertension by SAHR
19 Long-term Beneficial Metabolic Effects of Adrenalectomy in Subclinical Cushing's Syndrome of Adrenal Incidentaloma Recruiting NCT01382420 Not Applicable
20 Radiofrequency Endoscopic Ablation With Ultrasound Guidance: a Non-surgical Treatment for Aldosterone-producing Adenomas Recruiting NCT03405025 Not Applicable
21 Structured Evaluation of adRENal Tumors Discovered Incidentally - Prospectively Investigating the Testing Yield Recruiting NCT02324647
22 Effect of Chronic Catecholamine Overproduction on Brown Adipose Tissue Recruiting NCT01949714
23 Adrenalectomy Versus Follow-up in Patients With Subclinical Cushings Syndrome Recruiting NCT01246739 Not Applicable
24 Quality of Life, Fatigue and Cognitive, Affective and Emotional Dysfunction in Patients With Cushing's Syndrome Recruiting NCT03211624
25 Clinical and Molecular Characteristics of Primary Aldosteronism in Blacks Recruiting NCT03374215
26 Glucose Metabolism in Subjects With Aldosterone-Producing Adenomas Recruiting NCT02362308 Not Applicable mineralocorticoid receptor antagonist
27 Study of Adrenal Gland Tumors Recruiting NCT00005927
28 Renal Sympathetic Denervation From The Adventitia on Hypertension Recruiting NCT02642445 Not Applicable
29 Prospective Study Assessing Blood Pressure and Other Outcomes Post-treatment in Patients With Primary Aldosteronism Recruiting NCT03174847 Mineralocorticoid Receptor Antagonists
30 Morbidity and Mortality in Autonomous Cortisol Secretion Active, not recruiting NCT03919734
31 Radiofrequency Ablation for Aldosterone-producting Adenoma in Patients With Primary Aldosteronism Active, not recruiting NCT02756754 Not Applicable
32 Expression of Different Proliferation Biomarkers in Adreno-cortical Tumors Active, not recruiting NCT02747355
33 A Prospective Cohort Study for Patients With Adrenal Diseases Not yet recruiting NCT03474237
34 Rapid Cortisol Assay in Adrenal Vein Sampling Not yet recruiting NCT03449797 Not Applicable
35 Macrolides for KCNJ5 - Mutated Aldosterone-Producing Adenoma (MAPA) Not yet recruiting NCT03414918 Not Applicable Clarithromycin
36 A Study to Confirm Recurrent or Persistent Cushing's Syndrome in Patients With Signs or Symptoms of Hypercortisolemia Terminated NCT00796783 Cushing's syndrome confirmation

Search NIH Clinical Center for Adrenal Adenoma

Genetic Tests for Adrenal Adenoma

Anatomical Context for Adrenal Adenoma

MalaCards organs/tissues related to Adrenal Adenoma:

42
Adrenal Gland, Pituitary, Thyroid, Prostate, Kidney, Testes, Lung

Publications for Adrenal Adenoma

Articles related to Adrenal Adenoma:

(show top 50) (show all 342)
# Title Authors Year
1
Acromegaly associated with GIST, non-small cell lung carcinoma, clear cell renal carcinoma, multiple myeloma, medulla oblongata tumour, adrenal adenoma, and follicular thyroid nodules. ( 30742299 )
2019
2
Cardiovascular Outcomes in Autonomous Cortisol Secretion and Nonfunctioning Adrenal Adenoma: A Systematic Review. ( 31065617 )
2019
3
Non-surgically treated case of nonfunctioning ruptured adrenal adenoma in a patient on hemodialysis. ( 31073864 )
2019
4
Adrenal adenoma in von Hippel-Lindau syndrome: A case report with review of literature. ( 30900640 )
2019
5
A successful pregnancy in a patient with secondary hypertension caused by adrenal adenoma: a case report. ( 30943935 )
2019
6
A rare case of pure testosterone-secreting adrenal adenoma in a postmenopausal elderly woman. ( 30674304 )
2019
7
A Case of Primary Aldosteronism Due to A Primary Adrenal Adenoma Diagnosed by Segmental Adrenal Venous Sampling (S-AVS) Using a Modified Catheter System and Lateral Cine Angiography. ( 30710071 )
2019
8
Giant adrenal adenoma with hemorrhagic cystic degeneration. ( 30777257 )
2019
9
Central serous retinopathy as presentation of an adrenal adenoma. ( 30567268 )
2018
10
PREOPERATIVE TREATMENT WITH METYRAPONE IN PATIENTS WITH CUSHING'S SYNDROME DUE TO ADRENAL ADENOMA. ( 30352400 )
2018
11
Impact of body mass index on CT attenuation of adrenal adenoma. ( 30396653 )
2018
12
Adrenal incidentaloma: machine learning-based quantitative texture analysis of unenhanced CT can effectively differentiate sPHEO from lipid-poor adrenal adenoma. ( 30310515 )
2018
13
Visfatin levels in hormonally inactive adrenal adenoma and their association with metabolic parameters ( 29914251 )
2018
14
Lipid-poor adrenal adenoma versus metastasis in lung cancer: Diagnosis by "comparative enhancement" at multiphasic MR imaging. ( 29970786 )
2018
15
Relationship Among Tumor Attenuation Value of Pre-contrast Computed Tomography (CT), Washout Rate and Constituent Cells in Adrenal Adenoma: Proposition of a New Approach for Diagnosing Adrenal Adenoma on Dynamic CT. ( 30061247 )
2018
16
Clinical Characteristics of Aldosterone- and Cortisol-Coproducing Adrenal Adenoma in Primary Aldosteronism. ( 29770148 )
2018
17
A black adrenal adenoma with high FDG uptake on PET/CT scan in a patient with esophageal carcinoma: A case report. ( 29499515 )
2018
18
Secreting ectopic adrenal adenoma: A rare condition to be aware of. ( 29525561 )
2018
19
Integrated Imaging Characterization of Adrenal Adenoma: False-Positive Metaiodobenzylguanidine (MIBG) Findings of Adrenal Scintigraphy. ( 29662567 )
2017
20
Effects of Mifepristone on Nonalcoholic Fatty Liver Disease in a Patient with a Cortisol-Secreting Adrenal Adenoma. ( 29348947 )
2017
21
An exceedingly rare adrenal collision tumor: adrenal adenoma-metastatic breast cancer-myelolipoma. ( 29046752 )
2017
22
Reninoma coexisting with adrenal adenoma during pregnancy: A case report. ( 28521424 )
2017
23
Diagnostic accuracy of virtual non-contrast enhanced dual-energy CT for diagnosis of adrenal adenoma: A systematic review and meta-analysis. ( 28289937 )
2017
24
ADC histogram analysis for adrenal tumor histogram analysis of apparent diffusion coefficient in differentiating adrenal adenoma from pheochromocytoma. ( 27571307 )
2017
25
Comparison of Quantitative MRI and CT Washout Analysis for Differentiation of Adrenal Pheochromocytoma From Adrenal Adenoma. ( 27011100 )
2016
26
Characterization of Adrenal Adenoma by Gaussian Model-Based Algorithm. ( 27020253 )
2016
27
Cellular Pathophysiology of an Adrenal Adenoma-Associated Mutant of the Plasma Membrane Ca(2+)-ATPase ATP2B3. ( 27035656 )
2016
28
Increased 3β-hydroxysteroid dehydrogenase 2 and 17α-hydroxylase activities in a virilized adolescent female with adrenal adenoma: A case report. ( 26893641 )
2016
29
Adrenal Adenoma and Pheochromocytoma: Comparison of Multidetector CT Venous Enhancement Levels and Washout Characteristics. ( 26978001 )
2016
30
Gallium-68 PSMA uptake in adrenal adenoma. ( 26394552 )
2016
31
Bilateral Adrenal Adenoma Presented As Multiple Metatarsal And Phalangeal Fractures. ( 27299107 )
2015
32
The Importance of Exclusion of Obstructive Sleep Apnea During Screening for Adrenal Adenoma and Diagnosis of Pheochromocytoma. ( 26904704 )
2015
33
Robotic-assisted laparoscopic adrenalectomy for an adrenal adenoma. ( 26425459 )
2015
34
CT sensitivity for adrenal adenoma according to lesion size. ( 26254908 )
2015
35
Black adrenal adenoma causing Cushing's syndrome: 40 years ago and today. ( 26088906 )
2015
36
cAMP signaling in cortisol-producing adrenal adenoma. ( 26139209 )
2015
37
Poor head growth as a presenting sign of a cortisol-secreting adrenal adenoma in a 2-year-old boy. ( 25575422 )
2015
38
Rare anaphylaxis and functioning adrenal adenoma. ( 25583253 )
2015
39
A functioning adrenal adenoma and pheochromocytoma in the same adrenal gland: two discrete adrenal incidentalomas. ( 25589844 )
2015
40
Effectiveness of partial adrenalectomy for concomitant hypertension in patients with nonfunctional adrenal adenoma. ( 25305227 )
2015
41
A patient with pemphigus foliaceus and myasthenia gravis treated by a cortisol-secreting adrenal adenoma. ( 24931108 )
2015
42
CT sensitivities for large (≥3 cm) adrenal adenoma and cortical carcinoma. ( 25060750 )
2015
43
Posterior gastric diverticulum mimicking adrenal adenoma on imaging. ( 25535229 )
2014
44
Aldosterone- and cortisol-co-producing adrenal adenoma without clinical features of Cushing syndrome. ( 25228847 )
2014
45
Open-angle glaucoma secondary to Cushing syndrome related to an adrenal adenoma: case report. ( 25264153 )
2014
46
Spontaneous rupture of an adrenal adenoma managed by laparoscopic adrenalectomy: a case report. ( 24701740 )
2014
47
Characterization of lipid-poor adrenal adenoma: chemical-shift MRI and washout CT. ( 24758658 )
2014
48
Two rare cases of familial (mother and daughter) adrenocorticotropic hormone-independent Cushing's syndrome due to adrenal adenoma, as well as the asynchronous development of another contralateral adrenal adenoma in the mother. ( 24785891 )
2014
49
Imaging and management of a small cell lung cancer metastasis/adrenal adenoma collision tumor: a case report and review of the literature. ( 24571800 )
2014
50
Spironolactone interference in the immunoassay of androstenedione in a patient with a cortisol secreting adrenal adenoma. ( 24612380 )
2014

Variations for Adrenal Adenoma

ClinVar genetic disease variations for Adrenal Adenoma:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 MEN1 NM_000244.3(MEN1): c.1669A> T (p.Thr557Ser) single nucleotide variant Pathogenic rs121913035 GRCh37 Chromosome 11, 64571985: 64571985
2 MEN1 NM_000244.3(MEN1): c.1669A> T (p.Thr557Ser) single nucleotide variant Pathogenic rs121913035 GRCh38 Chromosome 11, 64804513: 64804513

Cosmic variations for Adrenal Adenoma:

9 (show top 50) (show all 93)
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM11552 TP53 adrenal gland,adrenal gland,adrenal cortical adenoma,NS c.775G>T p.D259Y 17:7674188-7674188 0
2 COSM45444 TP53 adrenal gland,adrenal gland,adrenal cortical adenoma,NS c.587G>T p.R196L 17:7674944-7674944 0
3 COSM43555 TP53 adrenal gland,adrenal gland,adrenal cortical adenoma,NS c.736A>G p.M246V 17:7674227-7674227 0
4 COSM43678 TP53 adrenal gland,adrenal gland,adrenal cortical adenoma,NS c.305C>T p.T102I 17:7676064-7676064 0
5 COSM43931 TP53 adrenal gland,adrenal gland,adrenal cortical carcinoma,functioning c.523C>A p.R175S 17:7675089-7675089 0
6 COSM11286 TP53 adrenal gland,adrenal gland,adrenal cortical carcinoma,functioning c.1015G>T p.E339* 17:7670694-7670694 0
7 COSM10801 TP53 adrenal gland,adrenal gland,adrenal cortical carcinoma,functioning c.404G>A p.C135Y 17:7675208-7675208 0
8 COSM10659 TP53 adrenal gland,adrenal gland,adrenal cortical carcinoma,functioning c.817C>T p.R273C 17:7673803-7673803 0
9 COSM11071 TP53 adrenal gland,adrenal gland,adrenal cortical carcinoma,functioning c.1009C>T p.R337C 17:7670700-7670700 0
10 COSM44175 TP53 adrenal gland,adrenal gland,adrenal cortical carcinoma,functioning c.644G>C p.S215T 17:7674887-7674887 0
11 COSM1367296 RB1 adrenal gland,adrenal gland,adrenal cortical adenoma,NS c.2094G>T p.R698S 13:48459821-48459821 0
12 COSM225014 RB1 adrenal gland,adrenal gland,adrenal cortical adenoma,NS c.1960G>A p.V654M 13:48456349-48456349 0
13 COSM26707 PRKAR1A adrenal gland,adrenal gland,adrenal cortical adenoma,NS c.664A>G p.K222E 17:68525868-68525868 0
14 COSM26708 PRKAR1A adrenal gland,adrenal gland,adrenal cortical adenoma,NS c.892-1G>A p.? 17:68529919-68529919 0
15 COSM4167506 PRKACA adrenal gland,adrenal gland,adrenal cortical adenoma,NS c.617T>G p.L206R 19:14097604-14097604 0
16 COSM5885970 PRKACA adrenal gland,adrenal gland,adrenal cortical adenoma,NS c.262C>G p.H88D 19:14102890-14102890 0
17 COSM6944239 PLCG2 adrenal gland,adrenal gland,adrenal cortical adenoma,NS c.615C>A p.F205L 16:81870902-81870902 0
18 COSM6944237 NUP93 adrenal gland,adrenal gland,adrenal cortical adenoma,NS c.2172G>T p.Q724H 16:56839556-56839556 0
19 COSM584 NRAS adrenal gland,adrenal gland,adrenal cortical adenoma,NS c.182A>G p.Q61R 1:114713908-114713908 0
20 COSM6944241 NF1 adrenal gland,adrenal gland,adrenal cortical adenoma,NS c.3265G>T p.E1089* 17:31232140-31232140 0
21 COSM22568 MEN1 adrenal gland,adrenal gland,adrenal cortical adenoma,NS c.325G>T p.E109* 11:64809785-64809785 0
22 COSM23025 MEN1 adrenal gland,adrenal gland,adrenal cortical adenoma,NS c.1654A>T p.T552S 11:64804513-64804513 0
23 COSM4445248 MEN1 adrenal gland,adrenal gland,adrenal cortical carcinoma,functioning c.1132G>T p.E378* 11:64805688-64805688 0
24 COSM4445249 MEN1 adrenal gland,adrenal gland,adrenal cortical carcinoma,functioning c.808C>A p.L270M 11:64807195-64807195 0
25 COSM4445247 MEN1 adrenal gland,adrenal gland,adrenal cortical carcinoma,functioning c.812G>C p.G271A 11:64807191-64807191 0
26 COSM4445246 MED12 adrenal gland,adrenal gland,adrenal cortical carcinoma,functioning c.4857G>T p.K1619N 23:71134842-71134842 0
27 COSM6944234 KMT2A adrenal gland,adrenal gland,adrenal cortical adenoma,NS c.8408C>A p.S2803* 11:118504309-118504309 0
28 COSM1684717 KCNJ5 adrenal gland,adrenal gland,adrenal cortical adenoma,NS c.451G>A p.G151R 11:128911724-128911724 0
29 COSM1684718 KCNJ5 adrenal gland,adrenal gland,adrenal cortical adenoma,NS c.503T>G p.L168R 11:128911776-128911776 0
30 COSM1684720 KCNJ5 adrenal gland,adrenal gland,adrenal cortical adenoma,NS c.451G>C p.G151R 11:128911724-128911724 0
31 COSM4745630 KCNJ5 adrenal gland,adrenal gland,adrenal cortical adenoma,NS c.343C>T p.R115W 11:128911616-128911616 0
32 COSM1732665 KCNJ5 adrenal gland,adrenal gland,adrenal cortical adenoma,NS c.376T>C p.W126R 11:128911649-128911649 0
33 COSM1717390 KCNJ5 adrenal gland,adrenal gland,adrenal cortical adenoma,NS c.433G>C p.E145Q 11:128911706-128911706 0
34 COSM1684719 KCNJ5 adrenal gland,adrenal gland,adrenal cortical adenoma,NS c.472A>G p.T158A 11:128911745-128911745 0
35 COSM4745631 KCNJ5 adrenal gland,adrenal gland,adrenal cortical adenoma,NS c.737A>G p.E246G 11:128912010-128912010 0
36 COSM5546565 KCNJ5 adrenal gland,adrenal gland,adrenal cortical adenoma,NS c.439G>C p.E147Q 11:128911712-128911712 0
37 COSM5990170 KCNJ5 adrenal gland,adrenal gland,adrenal cortical adenoma,NS c.461T>G p.F154C 11:128911734-128911734 0
38 COSM27887 GNAS adrenal gland,adrenal gland,adrenal cortical adenoma,NS c.601C>T p.R201C 20:58909365-58909365 0
39 COSM27899 GNAS adrenal gland,adrenal gland,adrenal cortical adenoma,NS c.601C>A p.R201S 20:58909365-58909365 0
40 COSM27895 GNAS adrenal gland,adrenal gland,adrenal cortical adenoma,NS c.602G>A p.R201H 20:58909366-58909366 0
41 COSM4962873 GNAS adrenal gland,adrenal gland,adrenal cortical adenoma,NS c.679C>G p.Q227E 20:58909540-58909540 0
42 COSM5667 CTNNB1 adrenal gland,adrenal gland,adrenal cortical adenoma,NS c.134C>T p.S45F 3:41224646-41224646 0
43 COSM5663 CTNNB1 adrenal gland,adrenal gland,adrenal cortical adenoma,NS c.133T>C p.S45P 3:41224645-41224645 0
44 COSM5692 CTNNB1 adrenal gland,adrenal gland,adrenal cortical adenoma,NS c.134C>A p.S45Y 3:41224646-41224646 0
45 COSM5689 CTNNB1 adrenal gland,adrenal gland,adrenal cortical adenoma,NS c.134C>G p.S45C 3:41224646-41224646 0
46 COSM17661 CTNNB1 adrenal gland,adrenal gland,adrenal cortical adenoma,NS c.130C>G p.P44A 3:41224642-41224642 0
47 COSM5678 CTNNB1 adrenal gland,adrenal gland,adrenal cortical adenoma,NS c.107A>C p.H36P 3:41224619-41224619 0
48 COSM5664 CTNNB1 adrenal gland,adrenal gland,adrenal cortical adenoma,NS c.121A>G p.T41A 3:41224633-41224633 0
49 COSM5686 CTNNB1 adrenal gland,adrenal gland,adrenal cortical adenoma,NS c.100G>A p.G34R 3:41224612-41224612 0
50 COSM5679 CTNNB1 adrenal gland,adrenal gland,adrenal cortical adenoma,NS c.110C>G p.S37C 3:41224622-41224622 0

Expression for Adrenal Adenoma

Search GEO for disease gene expression data for Adrenal Adenoma.

Pathways for Adrenal Adenoma

Pathways related to Adrenal Adenoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.88 CYP11A1 CYP11B1 CYP11B2 CYP17A1 CYP21A2 POMC
2
Show member pathways
12.62 CYP11A1 CYP11B1 CYP11B2 CYP17A1 CYP21A2 KCNJ5
3 11.83 CRH GIPR MC2R POMC
4 11.69 CRH CYP11A1 CYP11B1 CYP21A2 POMC
5
Show member pathways
11.6 CYP11A1 MC2R POMC
6
Show member pathways
11.25 CYP11A1 CYP11B1 CYP11B2 CYP17A1 CYP21A2 HSD11B1
7
Show member pathways
11.11 CYP11A1 CYP11B1 CYP11B2 CYP17A1 CYP21A2 HSD11B1
8 10.95 CYP11A1 HSD11B1
9
Show member pathways
10.9 CYP11B1 CYP11B2 CYP17A1 CYP21A2
10 10.28 CRH POMC

GO Terms for Adrenal Adenoma

Biological processes related to Adrenal Adenoma according to GeneCards Suite gene sharing:

(show all 16)
# Name GO ID Score Top Affiliating Genes
1 oxidation-reduction process GO:0055114 9.88 CYP11A1 CYP11B1 CYP11B2 CYP17A1 CYP21A2 HSD11B1
2 lipid metabolic process GO:0006629 9.86 CYP11A1 CYP11B1 CYP11B2 HSD11B1
3 cholesterol metabolic process GO:0008203 9.69 CYP11A1 CYP11B1 CYP11B2
4 regulation of blood pressure GO:0008217 9.67 CYP11B1 POMC REN
5 steroid biosynthetic process GO:0006694 9.65 CYP11A1 CYP11B1 CYP11B2 CYP17A1 CYP21A2
6 cellular response to peptide hormone stimulus GO:0071375 9.62 CYP11A1 CYP11B1 CYP11B2 MEN1
7 response to immobilization stress GO:0035902 9.55 CRH REN
8 positive regulation of cAMP-mediated signaling GO:0043950 9.54 CRH GIPR
9 C21-steroid hormone biosynthetic process GO:0006700 9.54 CYP11A1 CYP11B1 CYP11B2
10 cellular response to potassium ion GO:0035865 9.52 CYP11B1 CYP11B2
11 steroid metabolic process GO:0008202 9.5 CRH CYP11A1 CYP11B1 CYP11B2 CYP17A1 CYP21A2
12 mineralocorticoid biosynthetic process GO:0006705 9.48 CYP11B2 CYP21A2
13 aldosterone biosynthetic process GO:0032342 9.46 CYP11B1 CYP11B2
14 sterol metabolic process GO:0016125 9.46 CYP11A1 CYP11B1 CYP11B2 CYP21A2
15 cortisol biosynthetic process GO:0034651 9.43 CYP11B1 CYP11B2
16 glucocorticoid biosynthetic process GO:0006704 9.17 CRH CYP11A1 CYP11B1 CYP11B2 CYP17A1 CYP21A2

Molecular functions related to Adrenal Adenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 oxidoreductase activity GO:0016491 9.73 CYP11A1 CYP11B1 CYP11B2 CYP17A1 CYP21A2 HSD11B1
2 heme binding GO:0020037 9.55 CYP11A1 CYP11B1 CYP11B2 CYP17A1 CYP21A2
3 steroid binding GO:0005496 9.43 CYP21A2 HSD11B1
4 steroid hydroxylase activity GO:0008395 9.4 CYP11B2 CYP21A2
5 corticosterone 18-monooxygenase activity GO:0047783 9.37 CYP11B1 CYP11B2
6 iron ion binding GO:0005506 9.35 CYP11A1 CYP11B1 CYP11B2 CYP17A1 CYP21A2
7 steroid 11-beta-monooxygenase activity GO:0004507 9.32 CYP11B1 CYP11B2
8 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen GO:0016705 9.02 CYP11A1 CYP11B1 CYP11B2 CYP17A1 CYP21A2

Sources for Adrenal Adenoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
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52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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