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MCID: ADR009
MIFTS: 40

Adrenal Cortex Disease

Categories: Endocrine diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Adrenal Cortex Disease

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MalaCards integrated aliases for Adrenal Cortex Disease:

Name: Adrenal Cortex Disease 12 15
Adrenal Cortex Diseases 44 73

Classifications:

MalaCards categories:
Anatomical: Endocrine diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:3952
MeSH 44 D000303
SNOMED-CT 68 129636003
UMLS 73 C0001614
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Summaries for Adrenal Cortex Disease

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MalaCards based summary : Adrenal Cortex Disease, also known as adrenal cortex diseases, is related to primary pigmented nodular adrenocortical disease and acute adrenal insufficiency. An important gene associated with Adrenal Cortex Disease is POMC (Proopiomelanocortin), and among its related pathways/superpathways are Aldosterone synthesis and secretion and Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways. The drugs Cisplatin and Doxorubicin have been mentioned in the context of this disorder. Affiliated tissues include adrenal cortex, cortex and adrenal gland, and related phenotypes are Reduced mammosphere formation and behavior/neurological

Wikipedia : 76 Situated along the perimeter of the adrenal gland, the adrenal cortex mediates the stress response... more...

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Related Diseases for Adrenal Cortex Disease

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Diseases related to Adrenal Cortex Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 89)
# Related Disease Score Top Affiliating Genes
1 primary pigmented nodular adrenocortical disease 31.2 NR3C1 PDE11A POMC PRKAR1A
2 acute adrenal insufficiency 10.9 POMC REN
3 inappropriate adh syndrome 10.8 POMC REN
4 bronchus adenoma 10.7 POMC SST
5 acth deficiency, isolated 10.7 CRH POMC
6 acidophil adenoma 10.7 POMC SST
7 allergic urticaria 10.7 CRH NR3C1
8 hypoaldosteronism 10.7 CYP11B2 POMC REN
9 hypoadrenalism 10.6 CRH POMC
10 familial glucocorticoid deficiency 10.6 NR0B1 POMC REN
11 gonadal disease 10.6 CRH NR0B1 POMC
12 postural hypotension 10.6 REN SST
13 urinary system disease 10.6 CRH POMC REN
14 adrenal rest tumor 10.6 CYP11B1 CYP11B2 POMC
15 arthrogryposis, distal, type 3 10.5 NR3C2 REN
16 mental depression 10.5 CRH NR3C1 POMC
17 persistent fetal circulation syndrome 10.5 CRH HSD11B2 POMC
18 adrenal cortical adenoma 10.5 CYP11B1 POMC PRKAR1A
19 chronic fatigue syndrome 10.5 CRH NR3C1 POMC
20 fasting hypoglycemia 10.5 CRH POMC
21 hormone producing pituitary cancer 10.5 PRKAR1A SST
22 ectopic cushing syndrome 10.4 CRH POMC SST
23 pseudohypoaldosteronism, type i, autosomal dominant 10.4 NR3C2 REN
24 mood disorder 10.4 CRH NR3C1 POMC
25 corticosteroid-binding globulin deficiency 10.4 HSD11B2 NR3C1 POMC
26 adenohypophysitis 10.4 POMC PRL
27 glucose metabolism disease 10.4 POMC REN SST
28 pseudohyperkalemia, familial, 2, due to red cell leak 10.3 CYP11B2 NR3C2 REN
29 lipoid congenital adrenal hyperplasia 10.3 CYP11B1 CYP11B2 POMC REN
30 pituitary apoplexy 10.3 POMC PRL
31 aldosterone-producing adenoma 10.3 CYP11B2 KCNJ5 REN
32 sella turcica neoplasm 10.3 POMC PRL
33 anuria 10.2 HSD11B2 NR3C2 REN
34 tuberculum sellae meningioma 10.2 POMC PRL
35 familial hyperaldosteronism 10.2 CYP11B1 CYP11B2 KCNJ5
36 hypothalamic disease 10.2 CRH POMC PRL
37 sheehan syndrome 10.2 CRH POMC PRL
38 carney complex variant 10.2 PDE11A POMC PRKAR1A
39 steroid inherited metabolic disorder 10.2 CYP11B1 CYP11B2 HSD11B2 POMC
40 melancholia 10.2 CRH PRL
41 empty sella syndrome 10.2 POMC PRL
42 hypokalemia 10.2 HSD11B2 NR3C1 POMC REN
43 tsh producing pituitary tumor 10.2 PRL SST
44 amenorrhea 10.2 CRH POMC PRL
45 hypopituitarism 10.1 CRH POMC PRL
46 pituitary adenoma 1, multiple types 10.1 PRL SST
47 hypothyroidism, congenital, nongoitrous, 4 10.1 POMC PRL
48 anorexia nervosa 10.1 CRH POMC PRL
49 prolactin producing pituitary tumor 10.1 PRL SST
50 pituitary infarct 10.0 POMC PRL SST

Graphical network of the top 20 diseases related to Adrenal Cortex Disease:



Diseases related to Adrenal Cortex Disease
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Symptoms & Phenotypes for Adrenal Cortex Disease

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GenomeRNAi Phenotypes related to Adrenal Cortex Disease according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Reduced mammosphere formation GR00396-S 9.17 CYP11B1 HSD11B2 KCNJ5 NR0B1 NR3C1 NR3C2

MGI Mouse Phenotypes related to Adrenal Cortex Disease:

46 (show all 11)
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.27 NR3C2 AIRE HSD11B2 CRH NR3C1 CYP11B1
2 homeostasis/metabolism MP:0005376 10.22 CYP11B1 CYP11B2 NR3C2 AIRE HSD11B2 CRH
3 cardiovascular system MP:0005385 10.13 NR3C1 CYP11B1 NR3C2 CYP11B2 HSD11B2 KCNJ5
4 growth/size/body region MP:0005378 10.13 NR3C1 CYP11B1 CYP11B2 AIRE CRH NR3C2
5 endocrine/exocrine gland MP:0005379 10.11 CYP11B1 CYP11B2 AIRE NR0B1 CRH NR3C1
6 immune system MP:0005387 10.02 NR3C1 CYP11B2 AIRE CRH PRL REN
7 liver/biliary system MP:0005370 9.87 CYP11B2 AIRE CRH NR3C1 POMC PRKAR1A
8 nervous system MP:0003631 9.85 NR3C1 CYP11B2 AIRE CRH PDE11A REN
9 neoplasm MP:0002006 9.73 AIRE HSD11B2 NR0B1 POMC PRKAR1A PRL
10 normal MP:0002873 9.5 NR3C1 AIRE HSD11B2 CRH REN SST
11 renal/urinary system MP:0005367 9.23 CYP11B1 CYP11B2 NR3C2 HSD11B2 CRH NR3C1
Sources

Drugs & Therapeutics for Adrenal Cortex Disease

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Drugs for Adrenal Cortex Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 150)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cisplatin Approved Phase 3,Phase 2,Phase 1 15663-27-1 84093 441203 2767
2
Doxorubicin Approved, Investigational Phase 3,Phase 2,Phase 1 23214-92-8 31703
3
Etoposide Approved Phase 3,Phase 2 33419-42-0 36462
4
Lenograstim Approved, Investigational Phase 3 135968-09-1
5
Mitotane Approved Phase 3,Phase 2 53-19-0 4211
6
Streptozocin Approved, Investigational Phase 3 18883-66-4 29327
7
Doxil Approved June 1999 Phase 3,Phase 2,Phase 1 31703
8 Antineoplastic Agents, Phytogenic Phase 3,Phase 2,Phase 1
9 insulin Phase 3,Phase 2
10 Insulin, Globin Zinc Phase 3,Phase 2
11 Mitogens Phase 3,Phase 2
12 Adjuvants, Immunologic Phase 3,Phase 2,Phase 1
13 Anti-Bacterial Agents Phase 3,Phase 2,Phase 1
14 Antibiotics, Antitubercular Phase 3,Phase 2,Phase 1
15 Antineoplastic Agents, Hormonal Phase 3,Phase 2
16 Etoposide phosphate Phase 3,Phase 2
17 Topoisomerase Inhibitors Phase 3,Phase 2,Phase 1
18
Paclitaxel Approved, Vet_approved Phase 2,Phase 1 33069-62-4 36314
19
Sorafenib Approved, Investigational Phase 2 284461-73-0 216239 406563
20
Epinephrine Approved, Vet_approved Phase 2,Phase 1,Not Applicable 51-43-4 5816
21
Racepinephrine Approved Phase 2,Phase 1,Not Applicable 329-65-7 838
22
Sunitinib Approved, Investigational Phase 2 341031-54-7, 557795-19-4 5329102
23
Dexamethasone Approved, Investigational, Vet_approved Phase 2,Phase 1 50-02-2 5743
24
Hydrocortisone Approved, Vet_approved Phase 2,Phase 1,Not Applicable 50-23-7 5754
25
Axitinib Approved, Investigational Phase 2 319460-85-0 6450551
26
Etomidate Approved Phase 1, Phase 2 33125-97-2 36339 667484
27
Vincristine Approved, Investigational Phase 2 2068-78-2, 57-22-7 5978
28
Docetaxel Approved, Investigational Phase 2 114977-28-5 148124
29
Gefitinib Approved, Investigational Phase 2 184475-35-2 123631
30
Oxaliplatin Approved, Investigational Phase 2 61825-94-3 5310940 9887054 43805 6857599
31
Tamoxifen Approved Phase 2 10540-29-1 2733526
32
Suramin Approved, Investigational Phase 2,Phase 1 145-63-1 5361
33
nivolumab Approved Phase 2,Phase 1 946414-94-4
34
Pembrolizumab Approved Phase 2 1374853-91-4
35
Folic Acid Approved, Nutraceutical, Vet_approved Phase 2 59-30-3 6037
36
Niacin Approved, Investigational, Nutraceutical Phase 2 59-67-6 938
37
Nicotinamide Approved, Investigational, Nutraceutical Phase 2 98-92-0 936
38
acetic acid Approved, Nutraceutical Phase 2 64-19-7 176
39
Vitamin A Approved, Nutraceutical, Vet_approved Phase 2 11103-57-4, 68-26-8 445354
40
Citric Acid Approved, Nutraceutical, Vet_approved Phase 2 77-92-9 311
41
Lactitol Investigational Phase 2 585-86-4 3871
42 Gossypol Investigational Phase 2 303-45-7
43
Butyric Acid Experimental, Investigational Phase 2 107-92-6 264
44 Albumin-Bound Paclitaxel Phase 2,Phase 1
45 Antimitotic Agents Phase 2,Phase 1
46 Micronutrients Phase 2
47 Nicotinic Acids Phase 2
48 Protein Kinase Inhibitors Phase 2
49 Trace Elements Phase 2
50 Vitamin B Complex Phase 2

Interventional clinical trials:

(show top 50) (show all 68)
# Name Status NCT ID Phase Drugs
1 A Study of OSI-906 in Patients With Locally Advanced or Metastatic Adrenocortical Carcinoma Completed NCT00924989 Phase 3 OSI-906
2 Cisplatin-Based Chemotherapy and/or Surgery in Treating Young Patients With Adrenocortical Tumor Completed NCT00304070 Phase 3 doxorubicin hydrochloride;cisplatin;mitotane;etoposide
3 Trial in Locally Advanced and Metastatic Adrenocortical Carcinoma Treatment (FIRM-ACT) Completed NCT00094497 Phase 3 Etoposide;Doxorubicin;Cisplatin;Streptozotocin;Mitotane
4 Efficacy of Adjuvant Mitotane Treatment (ADIUVO) Recruiting NCT00777244 Phase 3 MITOTANE
5 Mitotane With or Without Cisplatin and Etoposide After Surgery in Treating Participants With Stage I-III Adrenocortical Cancer With High Risk of Recurrence Not yet recruiting NCT03583710 Phase 3 Cisplatin;Etoposide;Mitotane
6 Sorafenib Plus Paclitaxel in Adreno-Cortical-Cancer Patients Unknown status NCT00786110 Phase 2 Sorafenib;Paclitaxel
7 Sunitinib in Refractory Adrenocortical Carcinoma Unknown status NCT00453895 Phase 2 Sunitinib
8 Medical Safety Follow-up Study for Patients Who Received More Than 28 Days of Total Exposure to BGG492 Completed NCT02150213 Phase 2 BGG492
9 Phase II Study of Axitinib (AG-013736) With Evaluation of the VEGF-Pathway in Metastatic, Recurrent or Primary Unresectable Adrenocortical Cancer Completed NCT01255137 Phase 2 Axitinib
10 Clinical Trial of Dovitinib in First-line Metastatic or Locally Advanced Non-resectable Adrenocortical Carcinoma Completed NCT01514526 Phase 2 Dovitinib
11 A Study to Determine Safety, Pharmacokinetics and Pharmacodynamics of Intravenous TKM 080301 in Neuroendocrine Tumors (NET) and Adrenocortical Carcinoma (ACC) Patients Completed NCT01262235 Phase 1, Phase 2 TKM-080301
12 Gossypol Acetic Acid in Treating Patients With Recurrent, Metastatic, or Primary Adrenocortical Cancer That Cannot Be Removed By Surgery Completed NCT00848016 Phase 2 R-(-)-gossypol acetic acid
13 Cixutumumab in Treating Patients With Relapsed or Refractory Solid Tumors Completed NCT00831844 Phase 2
14 Evaluation of 123I-Iodometomidate for Adrenal Scintigraphy Completed NCT00454103 Phase 1, Phase 2 123I-Iodometomidate
15 Surgery Plus Chemotherapy (Doxorubicin, Vincristine and Etoposide), Mitotane, and Tariquidar to Treat Adrenocortical Cancer Completed NCT00071058 Phase 2 XR9576 (Tariquidar)
16 Trial With Taxotere and Cisplatin in Non-operable Adrenocortical Carcinoma Completed NCT00324012 Phase 2 cisplatin, taxotere
17 Phase II Trial of ZD1839 (Iressa) in Patients With Nonresectable Adrenocortical Carcinoma (ACC) Completed NCT00215202 Phase 2 Iressa (ZD1839)
18 Oxaliplatin in Treating Young Patients With Recurrent Solid Tumors That Have Not Responded to Previous Treatment Completed NCT00091182 Phase 2 oxaliplatin
19 Combination Chemotherapy and Tamoxifen in Treating Patients With Solid Tumors Completed NCT00002608 Phase 2 cisplatin;doxorubicin hydrochloride;tamoxifen citrate
20 A Study of Combination Chemotherapy and Surgical Resection in the Treatment of Adrenocortical Carcinoma: Continuous Infusion Doxorubicin, Vincristine and Etoposide With Daily Mitotane Before and After Surgical Resection Completed NCT00001339 Phase 2 doxorubicin, vincristine, and etoposide with mitotane
21 Cabozantinib in Unresectable/Metastatic Adrenocortical Carcinoma Recruiting NCT03370718 Phase 2 Cabozantinib
22 Nivolumab Combined With Ipilimumab for Patients With Advanced Rare Genitourinary Tumors Recruiting NCT03333616 Phase 2 Ipilimumab;Nivolumab
23 Cabazitaxel Activity in Patients With Advanced AdrenoCortical-Carcinoma Progressing After Previous Chemotherapy Lines Recruiting NCT03257891 Phase 2 Cabazitaxel
24 Surgery and Heated Intraperitoneal Chemotherapy for Adrenocortical Carcinoma Recruiting NCT03127774 Phase 2 Cisplatin;Sodium thiosulfate
25 Cabozantinib-S-Malate in Treating Younger Patients With Recurrent, Refractory, or Newly Diagnosed Sarcomas, Wilms Tumor, or Other Rare Tumors Recruiting NCT02867592 Phase 2 Cabozantinib S-malate
26 Nivolumab and Ipilimumab in Treating Patients With Rare Tumors Recruiting NCT02834013 Phase 2
27 Single Agent Pembrolizumab in Subjects With Advanced Adrenocortical Carcinoma Recruiting NCT02673333 Phase 2 Pembrolizumab
28 Study of Efficacy and Safety of Osilodrostat in Cushing's Syndrome Recruiting NCT02468193 Phase 2 Osilodrostat
29 Activity of Abiraterone Acetate in the Management of Cushing's Syndrome in Patients With Adrenocortical Carcinoma Active, not recruiting NCT03145285 Phase 2 Abiraterone Acetate
30 Nivolumab in Treating Patients With Metastatic Adrenocortical Cancer Active, not recruiting NCT02720484 Phase 2 Nivolumab
31 Surgery and Heated Chemotherapy for Adrenocortical Carcinoma Active, not recruiting NCT01833832 Phase 2 Cisplatin;sodium thiosulfate
32 IMC-A12 With Mitotane vs Mitotane Alone in Recurrent, Metastatic, or Primary ACC That Cannot Be Removed by Surgery Terminated NCT00778817 Phase 2 mitotane
33 S9427, Suramin in Treating Patients With Stage III or Stage IV Adrenocortical Cancer Incurable by Surgery Terminated NCT00002921 Phase 2 suramin;therapeutic hydrocortisone
34 Antineoplaston Therapy in Treating Patients With Stage IV Adrenal Gland Cancer Terminated NCT00003453 Phase 2 Antineoplaston therapy (Atengenal + Astugenal)
35 Treatment Study Using Bevacizumab for Patients With Adrenocortical Carcinoma Withdrawn NCT00469469 Phase 2 Bevacizumab
36 Adrenal Responsiveness During the Perioperative Period in Children Undergoing Congenital Cardiac Surgery Completed NCT01839812 Phase 1 Cosyntropin
37 Phase 1 Study of ATR-101 in Subjects With Advanced Adrenocortical Carcinoma Completed NCT01898715 Phase 1 ATR-101
38 Seneca Valley Virus-001 and Cyclophosphamide in Treating Young Patients With Relapsed or Refractory Neuroblastoma, Rhabdomyosarcoma, or Rare Tumors With Neuroendocrine Features Completed NCT01048892 Phase 1 cyclophosphamide
39 Continuous Hyperthermic Peritoneal Perfusion (CHPP) With Cisplatin for Children With Peritoneal Cancer Completed NCT00436657 Phase 1 CHPP of Cisplatin
40 Combination Chemotherapy With Suramin Plus Doxorubicin in Treating Patients With Advanced Solid Tumors Completed NCT00003038 Phase 1 doxorubicin hydrochloride;suramin
41 Interleukin-12 and Trastuzumab in Treating Patients With Cancer That Has High Levels of HER2/Neu Completed NCT00004074 Phase 1
42 A Dose-Escalation Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of IPI-549 Recruiting NCT02637531 Phase 1 IPI-549;Nivolumab
43 Possible New Therapy for Advanced Cancer Terminated NCT01832974 Phase 1 IL-13-PE
44 Veliparib, Capecitabine, and Temozolomide in Patients With Advanced, Metastatic, and Recurrent Neuroendocrine Tumor Withdrawn NCT02831179 Phase 1 Capecitabine;Temozolomide;Veliparib
45 The Effects of Case Management in a Medicaid Managed Care Plan Unknown status NCT00385879 Not Applicable
46 Long-term Beneficial Metabolic Effects of Adrenalectomy in Subclinical Cushing's Syndrome of Adrenal Incidentaloma Unknown status NCT01382420 Not Applicable
47 Primary Pigmented Nodular Adrenocortical Disease (PPNAD) and the CARNEY Complex (CNC) Completed NCT00668291
48 Cardiovascular Risk in Patients With Non-Functional Adrenal Incidentaloma Completed NCT00768365
49 Natural History and Tissue Acquisition Study of Adrenocortical Carcinoma Completed NCT02015026
50 Studying Genes in Samples From Younger Patients With Adrenocortical Tumor Completed NCT01528956

Search NIH Clinical Center for Adrenal Cortex Disease

Cochrane evidence based reviews: adrenal cortex diseases

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Genetic Tests for Adrenal Cortex Disease

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Anatomical Context for Adrenal Cortex Disease

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MalaCards organs/tissues related to Adrenal Cortex Disease:

41
Adrenal Cortex, Cortex, Adrenal Gland, Testes, Liver, Bone
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Publications for Adrenal Cortex Disease

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Articles related to Adrenal Cortex Disease:

# Title Authors Year
1
Hypertension and adrenal cortex disease. A review of 100 autopsied cases. ( 5491407 )
1970
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Variations for Adrenal Cortex Disease

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Expression for Adrenal Cortex Disease

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Search GEO for disease gene expression data for Adrenal Cortex Disease.
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Pathways for Adrenal Cortex Disease

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Pathways related to Adrenal Cortex Disease according to GeneCards Suite gene sharing:

(show all 11)
# Super pathways Score Top Affiliating Genes
1
Aldosterone synthesis and secretion 37
Show member pathways
 12.03 ARMC5 CRH CYP11B1 CYP11B2 KCNJ5 PDE11A
2
Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways 1
11.88 NR3C1 PRKAR1A SST
3
G alpha (s) signalling events 66
11.82 CRH PDE11A POMC
4
Corticotropin-releasing hormone signaling pathway 1
11.58 CRH CYP11B1 POMC
5
Nuclear Receptor transcription pathway 66
Show member pathways
 11.53 NR0B1 NR3C1 NR3C2
6
Glucocorticoid receptor regulatory network 1
11.46 NR3C1 POMC PRL
7
Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics 61
Show member pathways
 11.4 CYP11B2 NR3C2 REN
8
Steroid hormone biosynthesis 37
Show member pathways
 11.25 CYP11B1 CYP11B2 HSD11B2
9
Metabolism of steroid hormones 66
Show member pathways
 11.2 CYP11B1 CYP11B2 HSD11B2 POMC
10
superpathway of steroid hormone biosynthesis 1
Show member pathways
 10.78 CYP11B1 CYP11B2
11
Glucocorticoid Pathway (HPA Axis), Pharmacodynamics 61
10 CRH POMC
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GO Terms for Adrenal Cortex Disease

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Biological processes related to Adrenal Cortex Disease according to GeneCards Suite gene sharing:

(show all 23)
# Name GO ID Score Top Affiliating Genes
1 response to drug GO:0042493 9.88 CRH HSD11B2 REN SST
2 steroid metabolic process GO:0008202 9.77 CRH CYP11B1 CYP11B2
3 female pregnancy GO:0007565 9.74 CRH HSD11B2 PRL
4 regulation of blood pressure GO:0008217 9.7 CYP11B1 POMC REN
5 steroid biosynthetic process GO:0006694 9.69 CYP11B1 CYP11B2 NR0B1
6 steroid hormone mediated signaling pathway GO:0043401 9.67 NR0B1 NR3C1 NR3C2
7 sterol metabolic process GO:0016125 9.61 CYP11B1 CYP11B2
8 cellular response to peptide hormone stimulus GO:0071375 9.61 CYP11B1 CYP11B2
9 adrenal gland development GO:0030325 9.6 CRH NR0B1
10 hypothalamus development GO:0021854 9.58 CRH NR0B1
11 C21-steroid hormone biosynthetic process GO:0006700 9.56 CYP11B1 CYP11B2
12 small molecule metabolic process GO:0044281 9.55 CYP11B1 CYP11B2
13 cellular response to potassium ion GO:0035865 9.54 CYP11B1 CYP11B2
14 hormone-mediated apoptotic signaling pathway GO:0008628 9.48 CRH SST
15 secondary metabolite biosynthetic process GO:0044550 9.46 CYP11B1 CYP11B2
16 dehydroaustinol biosynthetic process GO:1900563 9.43 CYP11B1 CYP11B2
17 cortisol metabolic process GO:0034650 9.4 CYP11B1 CYP11B2
18 aldosterone biosynthetic process GO:0032342 9.37 CYP11B1 CYP11B2
19 austinol biosynthetic process GO:1900560 9.32 CYP11B1 CYP11B2
20 cortisol biosynthetic process GO:0034651 9.26 CYP11B1 CYP11B2
21 regulation of blood volume by renal aldosterone GO:0002017 9.16 CYP11B2 HSD11B2
22 response to immobilization stress GO:0035902 9.13 CRH NR0B1 REN
23 glucocorticoid biosynthetic process GO:0006704 8.92 CRH CYP11B1 CYP11B2 HSD11B2

Molecular functions related to Adrenal Cortex Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 steroid hormone receptor activity GO:0003707 9.5 NR0B1 NR3C1 NR3C2
2 steroid binding GO:0005496 9.43 HSD11B2 NR3C1 NR3C2
3 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen GO:0016709 9.37 CYP11B1 CYP11B2
4 corticosterone 18-monooxygenase activity GO:0047783 9.16 CYP11B1 CYP11B2
5 steroid 11-beta-monooxygenase activity GO:0004507 8.96 CYP11B1 CYP11B2
6 hormone activity GO:0005179 8.92 CRH POMC PRL SST
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Sources for Adrenal Cortex Disease

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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