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MCID: ADR009
MIFTS: 37

Adrenal Cortex Disease

Categories: Endocrine diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Adrenal Cortex Disease

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MalaCards integrated aliases for Adrenal Cortex Disease:

Name: Adrenal Cortex Disease 12 15
Adrenal Cortex Diseases 44 70

Classifications:

MalaCards categories:
Anatomical: Endocrine diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:3952
MeSH 44 D000303
SNOMED-CT 67 129636003
UMLS 70 C0001614
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Summaries for Adrenal Cortex Disease

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MalaCards based summary : Adrenal Cortex Disease, also known as adrenal cortex diseases, is related to primary pigmented nodular adrenocortical disease and familial glucocorticoid deficiency. An important gene associated with Adrenal Cortex Disease is MIR483 (MicroRNA 483), and among its related pathways/superpathways are Aldosterone synthesis and secretion and G alpha (s) signalling events. The drugs Epinephrine and Dexamethasone have been mentioned in the context of this disorder. Affiliated tissues include cortex, adrenal cortex and pituitary, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Wikipedia : 73 The adrenal cortex is the outer region and also the largest part of an adrenal gland. It is divided into... more...

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Related Diseases for Adrenal Cortex Disease

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Diseases related to Adrenal Cortex Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 168)
# Related Disease Score Top Affiliating Genes
1 primary pigmented nodular adrenocortical disease 32.0 PRKAR1A POMC PDE11A MIR483 MC2R CYP11B1
2 familial glucocorticoid deficiency 31.5 POMC NR5A1 NR0B1 MC2R CYP21A2 CYP11B2
3 conn's syndrome 29.7 PRKAR1A POMC PDE11A MC2R CYP21A2 CYP11B2
4 wissler-fanconi syndrome 10.5 POMC AIRE
5 nonsyndromic disorders of testicular development 10.5 NR5A1 NR0B1
6 breast ductal adenoma 10.5 PRKAR1A PDE11A
7 hypoaldosteronism 10.5 POMC CYP11B2
8 basophil adenoma 10.5 PRKAR1A POMC PDE11A
9 autoimmune hepatitis type 2 10.4 CYP21A2 CYP11A1
10 melanotic neurilemmoma 10.4 PRKAR1A POMC PDE11A
11 hormone producing pituitary cancer 10.4 PRKAR1A POMC PDE11A
12 autoimmune polyendocrine syndrome, type ii 10.4 NUDT10 CCR6 AIRE
13 cytochrome p450 oxidoreductase deficiency 10.4 POMC CYP21A2
14 pernicious anemia 10.4 NUDT10 CCR6 AIRE
15 atrophy of prostate 10.4 TP53 EPPIN
16 acth-independent cushing syndrome 10.4 PRKAR1A PDE11A
17 ectopic cushing syndrome 10.4 POMC CRH
18 aldosterone-producing adenoma 10.4 CYP21A2 CYP11B2
19 aromatase excess syndrome 10.4 POMC NR5A1 EPPIN
20 fasting hypoglycemia 10.4 POMC IGF2 CRH
21 waterhouse-friderichsen syndrome 10.4 POMC MC2R CYP21A2
22 pleuropulmonary blastoma 10.4 TP53 MIR483 IGF2
23 precocious puberty, male-limited 10.4 POMC NR0B1 CYP21A2
24 sebaceous gland disease 10.4 POMC CYP21A2 CCR6
25 testicular sex cord-stromal neoplasm 10.4 PDE11A CYP11A1
26 functioning pituitary adenoma 10.4 PRKAR1A POMC CRH
27 autoimmune disease of endocrine system 10.4 NUDT10 CCR6 AIRE
28 cardiovascular organ benign neoplasm 10.4 TP53 MIR139 CCR6
29 pituitary carcinoma 10.4 TP53 POMC CRH
30 acute adrenal insufficiency 10.4 POMC CYP21A2 CYP11A1
31 testicular leydig cell tumor 10.4 PDE11A CYP21A2
32 thymus gland disease 10.4 TP53 CCR6 AIRE
33 persistent fetal circulation syndrome 10.4 POMC IGF2 CRH
34 thymus cancer 10.4 TP53 CCR6 AIRE
35 persistent mullerian duct syndrome 10.4 NR5A1 NR0B1 CYP21A2
36 pre-malignant neoplasm 10.4 TP53 MIR139 CCR6
37 adult syndrome 10.4 POMC IGF2 CRH
38 testicular disease 10.4 TP53 EPPIN CCR6
39 skeletal muscle cancer 10.4 TP53 MIR675 IGF2
40 muscle cancer 10.4 TP53 MIR675 IGF2
41 breast adenoma 10.4 PRKAR1A PDE11A
42 pituitary infarct 10.4 POMC CRH
43 vitiligo-associated multiple autoimmune disease susceptibility 1 10.4 POMC CCR6 AIRE
44 x-linked monogenic disease 10.4 NR0B1 MIR675 MIR483 CCR6
45 inherited metabolic disorder 10.4 POMC MIR483 CYP21A2 CCR6
46 ovarian serous adenofibroma 10.4 TP53 POMC
47 androgen insensitivity syndrome 10.4 NR5A1 NR0B1 IGF2
48 hair disease 10.4 POMC CCR6 AIRE
49 mental depression 10.4 POMC CRH CCR6
50 polyendocrinopathy 10.4 CYP11A1 AIRE

Graphical network of the top 20 diseases related to Adrenal Cortex Disease:



Diseases related to Adrenal Cortex Disease
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Symptoms & Phenotypes for Adrenal Cortex Disease

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GenomeRNAi Phenotypes related to Adrenal Cortex Disease according to GeneCards Suite gene sharing:

26 (show all 30)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-100 10.21 CYP11A1 CYP21A2
2 Increased shRNA abundance (Z-score > 2) GR00366-A-102 10.21 NR5A1
3 Increased shRNA abundance (Z-score > 2) GR00366-A-105 10.21 CYP21A2
4 Increased shRNA abundance (Z-score > 2) GR00366-A-11 10.21 CYP11A1
5 Increased shRNA abundance (Z-score > 2) GR00366-A-12 10.21 TP53
6 Increased shRNA abundance (Z-score > 2) GR00366-A-120 10.21 CYP11A1 TP53
7 Increased shRNA abundance (Z-score > 2) GR00366-A-132 10.21 NR5A1 TP53
8 Increased shRNA abundance (Z-score > 2) GR00366-A-139 10.21 CYP21A2
9 Increased shRNA abundance (Z-score > 2) GR00366-A-145 10.21 CYP21A2
10 Increased shRNA abundance (Z-score > 2) GR00366-A-161 10.21 CYP21A2
11 Increased shRNA abundance (Z-score > 2) GR00366-A-166 10.21 CYP11A1
12 Increased shRNA abundance (Z-score > 2) GR00366-A-169 10.21 TP53
13 Increased shRNA abundance (Z-score > 2) GR00366-A-173 10.21 NR5A1
14 Increased shRNA abundance (Z-score > 2) GR00366-A-184 10.21 CYP11A1 CYP21A2 NR5A1 TP53
15 Increased shRNA abundance (Z-score > 2) GR00366-A-185 10.21 CYP21A2
16 Increased shRNA abundance (Z-score > 2) GR00366-A-19 10.21 TP53
17 Increased shRNA abundance (Z-score > 2) GR00366-A-190 10.21 TP53
18 Increased shRNA abundance (Z-score > 2) GR00366-A-20 10.21 TP53
19 Increased shRNA abundance (Z-score > 2) GR00366-A-202 10.21 NR5A1
20 Increased shRNA abundance (Z-score > 2) GR00366-A-203 10.21 CYP21A2
21 Increased shRNA abundance (Z-score > 2) GR00366-A-206 10.21 CYP21A2
22 Increased shRNA abundance (Z-score > 2) GR00366-A-208 10.21 CYP21A2
23 Increased shRNA abundance (Z-score > 2) GR00366-A-213 10.21 CYP21A2
24 Increased shRNA abundance (Z-score > 2) GR00366-A-35 10.21 TP53
25 Increased shRNA abundance (Z-score > 2) GR00366-A-39 10.21 TP53
26 Increased shRNA abundance (Z-score > 2) GR00366-A-42 10.21 CYP11A1 NR5A1
27 Increased shRNA abundance (Z-score > 2) GR00366-A-62 10.21 TP53
28 Increased shRNA abundance (Z-score > 2) GR00366-A-63 10.21 CYP21A2
29 Increased shRNA abundance (Z-score > 2) GR00366-A-8 10.21 CYP21A2
30 Reduced mammosphere formation GR00396-S 9.17 CCR6 CYP11B1 CYP21A2 IGF2 MC2R NR0B1

MGI Mouse Phenotypes related to Adrenal Cortex Disease:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.18 AIRE CRH CYP11A1 CYP11B1 CYP21A2 IGF2
2 endocrine/exocrine gland MP:0005379 10.18 AIRE CRH CYP11A1 CYP11B1 CYP11B2 IGF2
3 hematopoietic system MP:0005397 10.1 AIRE CCR6 CRH CYP11A1 CYP11B2 CYP21A2
4 homeostasis/metabolism MP:0005376 10.07 AIRE CCR6 CRH CYP11A1 CYP11B1 CYP11B2
5 immune system MP:0005387 9.9 AIRE CCR6 CRH CYP11A1 CYP11B2 CYP21A2
6 liver/biliary system MP:0005370 9.56 AIRE CRH CYP11A1 CYP11B2 IGF2 POMC
7 nervous system MP:0003631 9.36 AIRE CCR6 CRH CYP11A1 CYP11B2 IGF2
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Drugs & Therapeutics for Adrenal Cortex Disease

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Drugs for Adrenal Cortex Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 17)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Epinephrine Approved, Vet_approved Phase 1 51-43-4 5816
2
Dexamethasone Approved, Investigational, Vet_approved Phase 1 50-02-2 5743
3
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 1 1177-87-3
4
Racepinephrine Approved Phase 1 329-65-7 838
5
Hydrocortisone Approved, Vet_approved Phase 1 50-23-7 5754
6
Hydrocortisone acetate Approved, Vet_approved Phase 1 50-03-3
7
Cosyntropin Approved Phase 1 16960-16-0 16129617
8 Hormones Phase 1
9 Epinephryl borate Phase 1
10 Adrenocorticotropic Hormone Phase 1
11 Hormone Antagonists Phase 1
12 Melanocyte-Stimulating Hormones Phase 1
13 Hydrocortisone 17-butyrate 21-propionate Phase 1
14 Neurotransmitter Agents Phase 1
15 Hydrocortisone hemisuccinate Phase 1
16 Endorphins Phase 1
17 beta-Endorphin Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Adrenal Responsiveness During the Perioperative Period in Children Undergoing Congenital Cardiac Surgery Completed NCT01839812 Phase 1 Cosyntropin
2 Expression of Different Proliferation Biomarkers in Adreno-cortical Tumors Unknown status NCT02747355
3 The Effects of Case Management in a Medicaid Managed Care Plan Unknown status NCT00385879

Search NIH Clinical Center for Adrenal Cortex Disease

Cochrane evidence based reviews: adrenal cortex diseases

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Genetic Tests for Adrenal Cortex Disease

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Anatomical Context for Adrenal Cortex Disease

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MalaCards organs/tissues related to Adrenal Cortex Disease:

40
Cortex, Adrenal Cortex, Pituitary, Adrenal Gland, Breast, Thymus, Bone Marrow
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Publications for Adrenal Cortex Disease

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Articles related to Adrenal Cortex Disease:

(show all 26)
# Title Authors PMID Year
1
Tips for management of arrhythmias in endocrine disorders from an European Heart Rhythm Association position paper. 61
30297583 2018
2
[Therapy of adrenal cortex diseases]. 61
9581170 1998
3
[Diagnosis of adrenal cortex diseases]. 61
9556695 1998
4
[Perioperative steroid substitution in patients with adrenal cortex diseases]. 61
8504241 1993
5
[A literature review of adrenal cortex diseases in the cat and a description of a case of primary adrenal cortex insufficiency]. 61
3726515 1986
6
[Diagnosis of adrenal cortex diseases using radioimmunoassay of hormone levels in blood samples from the inferior vena cava and its tributaries]. 61
6321880 1984
7
[Intravenous metopiron test in normal persons and patients with adrenal cortex diseases]. 61
6298558 1982
8
[Diseases of the endocrine organs during pregnancy. 2. Thyroid and adrenal cortex diseases]. 61
6815040 1982
9
[Adrenal cortex diseases and acid-base imbalance]. 61
7334634 1981
10
[Reserve capacity of hypophyseal trophic hormones. Plasma ACTH levels and ACTH reserve in adrenal cortex diseases]. 61
6270611 1981
11
[Radionuclide scintigraphy in the differential diagnosis of adrenal cortex diseases in hypertension]. 61
7292299 1981
12
[Adrenal cortex diseases and hypertension]. 61
392139 1979
13
[Surgical treatment of adrenal cortex diseases]. 61
657421 1978
14
[Progress and present status of the surgical management of adrenal cortex diseases]. 61
908160 1977
15
[Production, metabolic clearance and mean plasma concentration of cortisol in normal subjects and in adrenal cortex diseases]. 61
950877 1976
16
Hypertension and adrenal cortex disease. A review of 100 autopsied cases. 61
5491407 1970
17
[The use of modified stimulation test in the diagnosis of adrenal cortex diseases]. 61
4310037 1969
18
[Occurrence of adrenal cortex diseases, pathologic serum albumin particles and vasculitis in chronic vegetating and fistulous pyoderma]. 61
5662277 1968
19
[Diagnosis of adrenal cortex diseases]. 61
5863929 1965
20
[CORTICOSTEROID CLEARANCE IN ADRENAL CORTEX DISEASES. INVESTIGATIONS WITH ACTH, CORTISONE, ALDOSTERONE AND HYDROCHLOROTHIAZIDE]. 61
14265046 1964
21
[ON THE CLASSIFICATION OF ADRENAL CORTEX DISEASES]. 61
14087975 1963
22
[Pregnancy in adrenal cortex diseases]. 61
13970640 1963
23
[ON THE TREATMENT OF ADRENAL CORTEX DISEASES]. 61
14068050 1963
24
[Determination of 17-ketosteroids & 17-hydroxycorticoids in urine as an aid for the diagnosis of adrenal cortex diseases]. 61
13625258 1958
25
[Indications for surgery of adrenal cortex diseases]. 61
13599952 1958
26
[Changes in blood & urinary adrenocortical steroid levels induced by ACTH & cortisone; their physiopathological significance in normal subjects & in adrenal cortex diseases]. 61
13490572 1957
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Variations for Adrenal Cortex Disease

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Expression for Adrenal Cortex Disease

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Search GEO for disease gene expression data for Adrenal Cortex Disease.
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Pathways for Adrenal Cortex Disease

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Pathways related to Adrenal Cortex Disease according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Aldosterone synthesis and secretion 36
Show member pathways
 12.09 POMC PDE11A NR5A1 NR0B1 MC2R CYP21A2
2
G alpha (s) signalling events 65
11.83 POMC PDE11A MC2R CRH
3
Diseases of metabolism 65
Show member pathways
 11.58 POMC MC2R CYP11A1
4
Corticotropin-releasing hormone signaling pathway 1
11.52 POMC CYP21A2 CYP11B1 CYP11A1 CRH
5
Steroid hormone biosynthesis 36
Show member pathways
 11.38 CYP21A2 CYP11B2 CYP11B1 CYP11A1
6
Metabolism of steroid hormones 65
Show member pathways
 11.26 POMC CYP21A2 CYP11B2 CYP11B1 CYP11A1
7
superpathway of steroid hormone biosynthesis 1
Show member pathways
 10.82 CYP21A2 CYP11B2 CYP11B1
8
Glucocorticoid Pathway (HPA Axis), Pharmacodynamics 60
10.25 POMC CRH
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GO Terms for Adrenal Cortex Disease

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Cellular components related to Adrenal Cortex Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 sperm plasma membrane GO:0097524 8.62 EPPIN CCR6

Biological processes related to Adrenal Cortex Disease according to GeneCards Suite gene sharing:

(show all 15)
# Name GO ID Score Top Affiliating Genes
1 steroid metabolic process GO:0008202 9.76 CYP21A2 CYP11B2 CYP11A1 CRH
2 cholesterol metabolic process GO:0008203 9.72 CYP11B2 CYP11B1 CYP11A1
3 steroid biosynthetic process GO:0006694 9.62 CYP21A2 CYP11B2 CYP11B1 CYP11A1
4 hypothalamus development GO:0021854 9.54 NR0B1 CRH
5 cellular response to peptide hormone stimulus GO:0071375 9.54 CYP11B2 CYP11B1 CYP11A1
6 cellular response to potassium ion GO:0035865 9.52 CYP11B2 CYP11B1
7 male sex determination GO:0030238 9.51 NR5A1 NR0B1
8 sex determination GO:0007530 9.49 NR5A1 NR0B1
9 mineralocorticoid biosynthetic process GO:0006705 9.48 CYP21A2 CYP11B2
10 sterol metabolic process GO:0016125 9.46 CYP21A2 CYP11B2 CYP11B1 CYP11A1
11 cortisol biosynthetic process GO:0034651 9.43 CYP11B2 CYP11B1
12 C21-steroid hormone biosynthetic process GO:0006700 9.43 CYP11B2 CYP11B1 CYP11A1
13 aldosterone biosynthetic process GO:0032342 9.4 CYP11B2 CYP11B1
14 cortisol metabolic process GO:0034650 9.13 CYP11B2 CYP11B1 CYP11A1
15 glucocorticoid biosynthetic process GO:0006704 8.92 CYP21A2 CYP11B2 CYP11B1 CYP11A1

Molecular functions related to Adrenal Cortex Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 heme binding GO:0020037 9.67 CYP21A2 CYP11B2 CYP11B1 CYP11A1
2 iron ion binding GO:0005506 9.62 CYP21A2 CYP11B2 CYP11B1 CYP11A1
3 corticosterone 18-monooxygenase activity GO:0047783 9.26 CYP11B2 CYP11B1
4 monooxygenase activity GO:0004497 9.26 CYP21A2 CYP11B2 CYP11B1 CYP11A1
5 steroid 11-beta-monooxygenase activity GO:0004507 9.16 CYP11B2 CYP11B1
6 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen GO:0016705 8.92 CYP21A2 CYP11B2 CYP11B1 CYP11A1
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Sources for Adrenal Cortex Disease

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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