Adrenal Cortex Disease disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Adrenal Cortex Disease

MalaCards integrated aliases for Adrenal Cortex Disease:

Name: Adrenal Cortex Disease ¹¹ ¹⁴

Adrenal Cortex Diseases ⁴³ ⁷¹

Classifications:

MalaCards categories:
Anatomical: Endocrine diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹¹ DOID:3952

MeSH ⁴³ D000303

SNOMED-CT ⁶⁸ 129636003

UMLS ⁷¹ C0001614

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Summaries for Adrenal Cortex Disease

MalaCards based summary: Adrenal Cortex Disease, also known as adrenal cortex diseases, is related to primary pigmented nodular adrenocortical disease and familial glucocorticoid deficiency. An important gene associated with Adrenal Cortex Disease is MIR483 (MicroRNA 483), and among its related pathways/superpathways are Diseases of glycosylation and Oxidation by cytochrome P450. The drugs Racepinephrine and Dexamethasone acetate have been mentioned in the context of this disorder. Affiliated tissues include adrenal cortex, cortex and heart, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Reduced mammosphere formation

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Related Diseases for Adrenal Cortex Disease

Diseases related to Adrenal Cortex Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 188)

#	Related Disease	Score	Top Affiliating Genes
1	primary pigmented nodular adrenocortical disease	32.0	PRKAR1A POMC PDE11A MIR483 MC2R CYP11B2
2	familial glucocorticoid deficiency	32.0	POMC NR5A1 NR0B1 MC2R CYP21A2 CYP11B2
3	acute adrenal insufficiency	30.5	POMC CYP21A2 CYP11A1
4	pituitary-dependent cushing's disease	30.5	POMC MC2R CRH
5	conn's syndrome	29.7	TP53 PRKAR1A POMC PDE11A NR5A1 NR0B1
6	wissler-fanconi syndrome	10.5	POMC AIRE
7	hypoaldosteronism	10.5	POMC CYP11B2
8	cutaneous candidiasis	10.5	NUDT10 CCR6 AIRE
9	basophil adenoma	10.5	PRKAR1A POMC PDE11A
10	hypoglycemic coma	10.5	POMC IGF2 EPPIN
11	autoimmune gastritis	10.5	NUDT10 CCR6 AIRE
12	melanotic neurilemmoma	10.4	PRKAR1A POMC PDE11A
13	prolactin producing pituitary tumor	10.4	TP53 POMC
14	premature ovarian failure 7	10.4	POMC NR5A1 CRH
15	autoimmune polyendocrine syndrome type 1	10.4	NUDT10 CCR6 AIRE
16	glycerol kinase deficiency	10.4	POMC NR5A1 NR0B1
17	androgen insensitivity, partial	10.4	NR5A1 NR0B1 EPPIN
18	pernicious anemia	10.4	NUDT10 CCR6 AIRE
19	mixed gonadal dysgenesis	10.4	NR5A1 NR0B1 CYP21A2
20	islet cell tumor	10.4	POMC MIR483 IGF2
21	waterhouse-friderichsen syndrome	10.4	POMC MC2R CRH
22	acth-secreting pituitary adenoma	10.4	PRKAR1A POMC CRH
23	pituitary cancer	10.4	TP53 PRKAR1A POMC
24	nail disease	10.4	NUDT10 CCR6 AIRE
25	hair disease	10.4	POMC CCR6 AIRE
26	mediastinal lipomatosis	10.4	POMC CRH
27	apparent mineralocorticoid excess	10.4	POMC CYP11B2 CYP11B1
28	functioning pituitary adenoma	10.4	PRKAR1A POMC CRH
29	ectopic cushing syndrome	10.4	POMC CRH
30	acth-independent cushing syndrome	10.4	PRKAR1A PDE11A
31	breast ductal adenoma	10.4	PRKAR1A PDE11A
32	multiple endocrine neoplasia, type i	10.4	PRKAR1A POMC MIR483 MIR139
33	colorectal adenoma	10.4	TP53 MIR139 CCR6
34	thymus gland disease	10.4	TP53 CCR6 AIRE
35	autoimmune polyendocrine syndrome, type ii	10.4	POMC NUDT10 CCR6 AIRE
36	leydig cell hypoplasia	10.4	NR5A1 EPPIN CYP11A1
37	thymus cancer	10.4	TP53 CCR6 AIRE
38	persistent mullerian duct syndrome	10.4	NR5A1 NR0B1 CYP21A2
39	vitiligo-associated multiple autoimmune disease susceptibility 1	10.4	POMC CCR6 AIRE
40	autoimmune polyendocrine syndrome, type i, with or without reversible metaphyseal dysplasia	10.4	CYP21A2 CYP11A1 AIRE
41	45,x/46,xy mixed gonadal dysgenesis	10.4	NR5A1 NR0B1
42	intellectual developmental disorder, x-linked, syndromic, wilson-turner type	10.4	TP53 MIR483 IGF2
43	persistent fetal circulation syndrome	10.4	POMC IGF2 CRH
44	bone resorption disease	10.4	MIR675 MIR483 MIR139 CCR6
45	pre-malignant neoplasm	10.4	TP53 MIR139 CCR6
46	autoimmune disease of endocrine system	10.4	POMC NUDT10 CCR6 AIRE
47	cardiovascular organ benign neoplasm	10.4	TP53 MIR139 CCR6
48	adult syndrome	10.4	POMC IGF2 CRH
49	reproductive system disease	10.4	MIR483 MIR139 EPPIN CCR6
50	liddle syndrome 1	10.4	POMC CYP11B2 CYP11B1

Graphical network of the top 20 diseases related to Adrenal Cortex Disease:

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Symptoms & Phenotypes for Adrenal Cortex Disease

GenomeRNAi Phenotypes related to Adrenal Cortex Disease according to GeneCards Suite gene sharing:

²⁵ (show all 30)

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Increased shRNA abundance (Z-score > 2)	GR00366-A-100	10.21	CYP11A1 CYP21A2
2	Increased shRNA abundance (Z-score > 2)	GR00366-A-102	10.21	NR5A1
3	Increased shRNA abundance (Z-score > 2)	GR00366-A-105	10.21	CYP21A2
4	Increased shRNA abundance (Z-score > 2)	GR00366-A-11	10.21	CYP11A1
5	Increased shRNA abundance (Z-score > 2)	GR00366-A-12	10.21	TP53
6	Increased shRNA abundance (Z-score > 2)	GR00366-A-120	10.21	CYP11A1 TP53
7	Increased shRNA abundance (Z-score > 2)	GR00366-A-132	10.21	NR5A1 TP53
8	Increased shRNA abundance (Z-score > 2)	GR00366-A-139	10.21	CYP21A2
9	Increased shRNA abundance (Z-score > 2)	GR00366-A-145	10.21	CYP21A2
10	Increased shRNA abundance (Z-score > 2)	GR00366-A-161	10.21	CYP21A2
11	Increased shRNA abundance (Z-score > 2)	GR00366-A-166	10.21	CYP11A1
12	Increased shRNA abundance (Z-score > 2)	GR00366-A-169	10.21	TP53
13	Increased shRNA abundance (Z-score > 2)	GR00366-A-173	10.21	NR5A1
14	Increased shRNA abundance (Z-score > 2)	GR00366-A-184	10.21	CYP11A1 CYP21A2 NR5A1 TP53
15	Increased shRNA abundance (Z-score > 2)	GR00366-A-185	10.21	CYP21A2
16	Increased shRNA abundance (Z-score > 2)	GR00366-A-19	10.21	TP53
17	Increased shRNA abundance (Z-score > 2)	GR00366-A-190	10.21	TP53
18	Increased shRNA abundance (Z-score > 2)	GR00366-A-20	10.21	TP53
19	Increased shRNA abundance (Z-score > 2)	GR00366-A-202	10.21	NR5A1
20	Increased shRNA abundance (Z-score > 2)	GR00366-A-203	10.21	CYP21A2
21	Increased shRNA abundance (Z-score > 2)	GR00366-A-206	10.21	CYP21A2
22	Increased shRNA abundance (Z-score > 2)	GR00366-A-208	10.21	CYP21A2
23	Increased shRNA abundance (Z-score > 2)	GR00366-A-213	10.21	CYP21A2
24	Increased shRNA abundance (Z-score > 2)	GR00366-A-35	10.21	TP53
25	Increased shRNA abundance (Z-score > 2)	GR00366-A-39	10.21	TP53
26	Increased shRNA abundance (Z-score > 2)	GR00366-A-42	10.21	CYP11A1 NR5A1
27	Increased shRNA abundance (Z-score > 2)	GR00366-A-62	10.21	TP53
28	Increased shRNA abundance (Z-score > 2)	GR00366-A-63	10.21	CYP21A2
29	Increased shRNA abundance (Z-score > 2)	GR00366-A-8	10.21	CYP21A2
30	Reduced mammosphere formation	GR00396-S	9.17	CCR6 CYP11B1 CYP21A2 IGF2 MC2R NR0B1

MGI Mouse Phenotypes related to Adrenal Cortex Disease:

⁴⁵ (show all 12)

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	homeostasis/metabolism	MP:0005376	10.31	AIRE CCR6 CRH CYP11A1 CYP11B1 CYP11B2
2	nervous system	MP:0003631	10.29	AIRE CCR6 CRH CYP11A1 CYP11B1 CYP11B2
3	growth/size/body region	MP:0005378	10.25	AIRE CRH CYP11A1 CYP11B1 CYP11B2 CYP21A2
4	endocrine/exocrine gland	MP:0005379	10.21	AIRE CRH CYP11A1 CYP11B1 CYP11B2 EPPIN
5	liver/biliary system	MP:0005370	10.13	AIRE CRH CYP11A1 CYP11B1 CYP11B2 IGF2
6	renal/urinary system	MP:0005367	10.1	CRH CYP11B1 CYP11B2 EPPIN IGF2 POMC
7	behavior/neurological	MP:0005386	10.07	AIRE CRH CYP11A1 CYP11B1 CYP11B2 CYP21A2
8	cardiovascular system	MP:0005385	10.06	CCR6 CYP11A1 CYP11B1 CYP11B2 EPPIN IGF2
9	adipose tissue	MP:0005375	10	CRH CYP11B1 CYP11B2 MC2R POMC PRKAR1A
10	immune system	MP:0005387	10	AIRE CCR6 CRH CYP11A1 CYP11B1 CYP11B2
11	reproductive system	MP:0005389	9.73	AIRE CYP11A1 CYP11B1 CYP11B2 EPPIN IGF2
12	hematopoietic system	MP:0005397	9.47	AIRE CCR6 CRH CYP11A1 CYP11B1 CYP11B2

Sources

Drugs & Therapeutics for Adrenal Cortex Disease

Drugs for Adrenal Cortex Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 16)

#

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

1

Racepinephrine

Approved, Vet_approved

Phase 1

51-43-4, 329-65-7

838 5816

Synonyms:

(−)-(R)-epinephrine

(-)-(R)-Epinephrine

(-)-3,4-Dihydroxy-a-((methylamino)methyl)benzyl alcohol

(-)-3,4-Dihydroxy-a-[(methylamino)methyl]-benzyl alcohol

(-)-3,4-Dihydroxy-a-[2-(methylamino)ethyl]benzyl alcohol

(-)-3,4-Dihydroxy-alpha-((methylamino)methyl)benzyl alcohol

(-)-3,4-Dihydroxy-alpha-[(methylamino)methyl]-benzyl alcohol

(-)-3,4-DIHYDROXY-ALPHA-[(METHYLAMINO)METHYL]BENZYL ALCOHOL(-)-3,4-DIHYDROXY-ALPHA-[(METHYLAMINO)METHYL]-BENZYL ALCOHOL

(-)-3,4-Dihydroxy-alpha-[2-(methylamino)ethyl]benzyl alcohol

(−)-3,4-dihydroxy-α-((methylamino)methyl)benzyl alcohol

(-)-3,4-Dihydroxy-α-((methylamino)methyl)benzyl alcohol

(-)-Adrenaline

(−)-ADRENALINE

(-)-Epinephrine

(+-)-Adrenaline

(+-)-Epinephrine

(R)-(-)-Adnephrine

(R)-(-)-Adrenaline

(R)-(−)-ADRENALINE

(R)-(-)-Epinephrine

(R)-(-)-Epirenamine

(R)-4-[1-Hydroxy-2-(methylamino)ethyl]-1,2-benzenediol

(R)-Adrenaline

(R)-Epinephrine

2-(Methylamino)-1-(3,4-dihydroxyphenyl)ethanol

4-(1-Hydroxy-2-(methylamino)ethyl)-1,2-benzenediol

4-[(1R)-1-Hydroxy-2-(methylamino)ethyl]-1,2-benzenediol

4-[(1R)-1-HYDROXY-2-METHYLAMINOETHYL]BENZENE-1,2-DIOL

4-[(1R)-1-HYDROXY-2-METHYLAMINO-ETHYL]BENZENE-1,2-DIOL

4-[(1R)-1-HYDROXY-2-METHYLAMINO-ETHYL]PYROCATECHOL

Acetate, epinephrine

Adnephrine

ADREN CO

ADRENACLICK

Adrenal

Adrenalin

Adrenaline

Adrénaline

Adrenaline acid tartrate

Adrenaline bitartrate

Adrenaline hydrochloride

Adrenaline hydrochloride, racemic mixture

Adrenaline, racemic

Adrenaline, racemic mixture

adrenaline|epinephrine

Adrenine

Adrin

Allergan brand OF adrenaline hydrochloride

ANA-GUARD

Ana-kit

ANAPEN

ANAPHYLACTIC SHOCK DRUG KIT

ASMA-VYDRIN

ASTHMAHALER

Auvi-Q

Bird brand OF racepinefrine hydrochloride

Bosmin

Bronkaid mist

BROVON

Chelafrin

DL-Adrenaline

EMERADE

EPI E Z PEN JR

Epifrin

Epiglaufrin

Epinefrin

Epinefrina

Epinephran

Epinephrin

EPINEPHRINE

Epinephrine acetate

Epinephrine bitartrate

EPINEPHRINE HCL

Epinephrine hydrochloride

Epinephrine hydrochloride, racemic mixture

Epinephrine hydrogen tartrate

Epinephrine racemic

Epinephrine, racemic

Epinephrine, racemic mixture

Epinephrinum

Epipen

EPIPEN E Z PEN

Epipen JR

EPIPEN JR.

Epirenan

Epitrate

Eppy

Exadrin

Glauposine

GPPE INH SOLN

Hemisine

Hemostasin

Hemostatin

Hydrochloride, racepinephrine

Hypernephrin

Isoptoepinal

JEXT

L-1-(3,4-Dihydroxyphenyl)-2-methylaminoethanol

L-Adrenaline

L-DETHYLAMINOETHANOLCATECHOL

L-Epinephrine

L-Epirenamine

Levoepinephrine

LEVO-METHYLAMINOETHANOLCATECHOL

Levorenen

Levorenin

Levorenine

Levoreninum

L-Methylaminoethanolcatechol

Lyodrin

Lyophrin

Medihaler-epi

Methylarterenol

Micronefrin

Micronephrine

Mixture adrenaline, racemic

Mixture epinephrine, racemic

Mucidrina

Nephridine

Nieraline

NSC-62786

Paranephrin

Primatene

Primatene mist

R-(-)-Epinephrine

Racemic adrenaline

Racemic epinephrine

Racemic mixture adrenaline

Racemic mixture epinephrine

Racepinefrina

Racepinefrine

Racepinefrinum

Racepinephrine

Racepinephrine hydrochloride

Renaglandin

Renaleptine

Renalina

Renoform

Renostypticin

Renostyptin

RIDDOBRON

RIDDOFAN

RYBARVIN

Scurenaline

Simplene

SOLN MADE TO RYBARVIN FOR

Styptirenal

Supracapsulin

Supranephrane

Suprarenaline

Suprarenin

Surrenine

Sus-phrine

SUS-PHRINE SULFITE FREE

SUS-PHRINE SULFITE-FREE

SYMJEPI

Takamina

TWINJECT

TWINJECT 0.15

TWINJECT 0.3

Vaponefrin

Vasoconstrictine

Vasotonin

2

Dexamethasone acetate

Approved, Investigational, Vet_approved

Phase 1

1177-87-3

3680

3

Dexamethasone

Approved, Investigational, Vet_approved

Phase 1

50-02-2

3003 5743

Synonyms:

[<sup>3</sup>H]-dexamethasone

16alpha -Methyl-9alpha -fluoro-1-dehydrocortisol

16alpha -Methyl-9alpha -fluoroprednisolone

16alpha-Methyl-9alpha-fluoro-1-dehydrocortisol

16-alpha-Methyl-9-alpha-fluoro-1-dehydrocortisol

16-alpha-Methyl-9-alpha-fluoro-delta1-hydrocortisone

16alpha-Methyl-9alpha-fluoroprednisolone

16-alpha-Methyl-9-alpha-fluoroprednisolone

16a-Methyl-9a-fluoro-1-dehydrocortisol

16Α-methyl-9α-fluoro-1-dehydrocortisol

1-Dehydro-16alpha -methyl-9alpha -fluorohydrocortisone

1-Dehydro-16alpha-methyl-9alpha-fluorohydrocortisone

1-Dehydro-16a-methyl-9a-fluorohydrocortisone

1-Dehydro-16α-methyl-9α-fluorohydrocortisone

9a-Fluoro-16a-methylprednisolone

9a-Fluoro-16BETA-methylprednisolone

9alpha -Fluoro-16alpha -methylprednisolone

9alpha-Fluoro-16alpha-methylprednisolone

9alpha-Fluoro-16alpha-methyl-prednisolone

9-alpha-Fluoro-16-alpha-methylprednisolone

9-Fluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione

9-Fluoro-11alpha -methylpregna-1,4-diene-3,20-dione

9-Fluoro-16-methylprednisolone

9Α-fluoro-16α-methylprednisolone

Adexone

Aeroseb-D

Aeroseb-dex

Ak dex OPH otic soln 0.1%

Alcon brand OF dexamethasone

alpha -Fluoro-16-alpha -methylcortisol

Anaflogistico

Aphtasolon

Aphthasolone

Apo-dexamethasone

Auxiron

Azimycin (veterinary)

Azium

Azium (veterinary)

Bisu DS

Calonat

Corson

Corsone

Cortisumman

DALALONE

Decacort

Decacortin

Decaderm

Decadron

Decadron Tablets, Elixir

Decadron®|desametasone|fluormethylprednisolone

DECADRON-75

DECADRON-LA

Decagel

Decaject

Decaject l.a.

Decaject-l.a.

Decalix

Decameth

Decasone

Decaspray

Dectancyl

Dekacort

Delta1-9alpha-Fluoro-16alpha-methylcortisol

Deltafluorene

Dergramin

Deronil

Desadrene

Desametasone

Desametasone [Dcit]

Desamethasone

Desameton

Deseronil

DEX

DEXA

Dexa mamallet

DEXACEN-4

Dexacidin

Dexacort

Dexacortal

Dexa-cortidelt

Dexacortin

Dexa-cortisyl

DEXACORTISYL

Dexadeltone

Dexafarma

DEXAFREE

DEXAIR

Dexalona

Dexaltin

Dexa-Mamallet

Dexametasona

Dexametasona [INN-Spanish]

Dexametasone

Dexameth

Dexamethansone

DEXAMETHASONE

Dexaméthasone

Dexamethasone acetate

Dexamethasone alcohol

Dexamethasone base

Dexamethasone intensol

DEXAMETHASONE METASULFOBENZOATE SODIUM

DEXAMETHASONE PALMITATE

Dexamethasone sodium phosphate

DEXAMETHASONE VALERATE

Dexamethasone-omega

Dexamethasonum

Dexamethasonum [INN-Latin]

Dexamethazone

Dexamonozon

Dexapolcort

Dexapos

Dexaprol

Dexa-scheroson

Dexa-sine

Dexason

Dexasone

Dexasone 0.5MG

Dexasone 0.75MG

Dexasone 4MG

Dexasporin

Dex-ide

Dexinolon

Dexinoral

Dexone

DEXONE 0.5

DEXONE 0.75

DEXONE 1.5

DEXONE 4

Dexonium

Dexpak

DEXSOL

Dextelan

DEXTENZA

DEXYCU KIT

Dezone

Dinormon

DROPODEX

DXM

DXM833

DXMS

ECR brand OF dexamethasone

Fluormethylprednisolone

Fluormone

Fluorocort

Fortecortin

Foy brand OF dexamethasone

Gammacorten

GPPE EAR SPY

Hexadecadrol

Hexadrol

Hexadrol elixir

Hexadrol Tablets

HL-Dex

ICN brand OF dexamethasone

IontoDex

Isopto-dex

ISV-305

KORTICO INJECTION

Lokalison F

Loverine

Luxazone

MARTAPAN

Maxidex

Maxidex ont 0.1%

Maxidex sus 0.1%

Maxitrol

Mediamethasone

Merck brand OF dexamethasone

Merz brand 1 OF dexamethasone

Merz brand 2 OF dexamethasone

Methylfluorprednisolone

Mexidex

Millicorten

Mymethasone

Naquasone (veterinary)

NEODECADRON

Neomycin and polymyxin b sulfates and dexamethasone

Neomycin and polymyxin b sulphates and dexamethasone

NSC 34521

NSC-34521

Ocu-trol

Oradexon

OTO-104

OTOMIZE

OZURDEX

Pet derm III

Pet-Derm Iii

PHL-Dexamethasone

PMS Dexamethasone elixir 0.5mg/5ML

PMS-Dexamethasone

Policort

Posurdex

Prednisolon F

Prednisolone F

Prodex

Sandoz dexamethasone

SK-Dexamethasone

SOFRADEX

SPERSADEX COMP

Spoloven

Sunia sol D

Superprednol

Tobradex

Tobramycin and dexamethasone

Tresaderm (veterinary)

Turbinaire

Visumetazone

4

Hydrocortisone succinate

Approved

Phase 1

2203-97-6

3643

5

Hydrocortisone acetate

Approved, Vet_approved

Phase 1

50-03-3

6

Hydrocortisone

Approved, Vet_approved

Phase 1

50-23-7

3640 5754

Synonyms:

(11ALPHA,14BETA)-11,17,21-TRIHYDROXYPREGN-4-ENE-3,20-DIONE

(11b)-11,17,21-Trihydroxypregn-4-ene-3,20-dione

(11beta)-11,17,21-Trihydroxypregn-4-ene-3,20-dione

(11Β)-11,17,21-trihydroxypregn-4-ene-3,20-dione

(1S,2R,10S,11S,14S,15S,17S)-14,17-DIHYDROXY-14-(2-HYDROXYACETYL)-2,15-DIMETHYLTETRACYCLO[8.7.0.0^{2,7}.0^{11,15}]HEPTADEC-6-EN-5-ONE

11 Epicortisol

11a-Hydroxycorticosterone

11alpha-Hydroxycorticosterone

11b,17,21-Trihydroxyprogesterone

11b,17a,21-Trihydroxy-4-pregnene-3,20-dione

11beta,17,21-Trihydroxyprogesterone

11beta,17alpha,21-Trihydroxy-4-pregnene-3,20-dione

11beta-Hydrocortisone

11-beta-Hydrocortisone

11beta-Hydroxycortisone

11-beta-Hydroxycortisone

11b-Hydrocortisone

11b-Hydroxycortisone

11-Epicortisol

11-Hydrocortisone

11Β,17α,21-trihydroxy-4-pregnene-3,20-dione

11Β-hydrocortisone

17a-Hydroxycorticosterone

17alpha-Hydroxycorticosterone

17-Hydroxycorticosterone

4-Pregnen-11b,17a,21-triol-3,20-dione

4-Pregnen-11beta,17alpha,21-triol-3,20-dione

4-Pregnen-11β,17α,21-triol-3,20-dione

4-Pregnene-11alpha,21-triol 3,20-dione

4-Pregnene-11b,17a,21-triol-3,20-dione

ACETASOL HC

ACTICO МИХАИЛRT

Acticort

Acticort®|Efmody®|Plenadren®

Aeroseb HC

Aeroseb-HC

Alacort

Ala-cort

Ala-scalp

Algicirtis

Alphaderm

Amberin

Anflam

Anti-inflammatory hormone

Anucort-HC

ANUGESIC HC

Anusol HC

ANUSOL PLUS HC

ANUSOL SOOTHING RELIEF

Anusol-HC

Aquacort

Aquanil HC

Balneol-HC

Barseb HC

Basan-corti

Beta-HC

b-HC

CaldeCORT spray

CALMURID HC

CANESTEN HC

Cetacort

Chronocort

CIPRO HC

Clear aid

Cleiton

Cobadex

Colocort

Compound F

CORLAN

Cor-oticin

Cortanal

Cor-tar-quin

Cort-dome

Cortef

CORTENEM

Cortenema

Cortesal

Corticreme

Cortifair

Cortifan

Cortifoam

Cortiment

Cortisol

Cortisol alcohol

Cortisolonum

Cortisporin

Cortisporin otico

Cortispray

Cortizol

Cortolotion

Cortonema

Cortoxide

Cort-quin

CORTRIL

Cremesone

Cremicort-H

Cutisol

DAKTACORT

DAKTACORT HYDROCORT

Delacort

DERMA CARE HYDROCORT

Dermacort

Derm-aid

DERMASPRAY DEMANG

Dermil

Dermolate

Dihydrocostisone

Dioderm

Dome-cort

Domolene-HC

Drotic

ECONACORT

Ef corlin

Efcorbin

Efcortelan

EFCORTELAN P

Efcortelin

Eldecort

Eldercort

Epicort

Epicortisol

Epiderm H

Esiderm H

EURAX-HC

EURAX-HYDROCORT

Evacort

EXE-CORT

Ficortril

Fiocortril

Flexicort

Foille insetti

Genacort

GERMOLOIDS HC

Glycort

GREGODERM

gyno-Cortisone

HC

HC #1

HC #4

HC (HYDROCORTISONE)

HC45

H-Cort

Heb cort

Heb-cort

Hi-cor

Hidalone

hidro-Colisona

Hidrocortisona

Hycort

Hycortol

Hycortole

Hydracort

Hydrasson

hydro-Adreson

hydro-Colisona

Hydrocort

HYDROCORT IN CALAMINE OILY

HYDROCORT IN CETOMACROGOL FOR A

HYDROCORT IN WTE SOFT PARAF

Hydrocortal

Hydrocorticosterone

Hydrocortisone

Hydrocortisone acetate

Hydrocortisone alcohol

Hydrocortisone base

Hydrocortisone butyrate

Hydrocortisone free alcohol

Hydrocortisone in absorbase

Hydrocortisone sodium phosphate

Hydrocortisone valerate

Hydrocortisone, (11 alpha)-isomer

Hydrocortisone, (9 beta,10 alpha,11 alpha)-isomer

Hydrocortisonum

Hydrocortistab

Hydrocortisyl

HYDROCORTONE

HYDRODERM

HYDRODERM HC

hydro-RX

Hydroskin

Hydroxycortisone

Hysone

Hytisone

Hytone

Hytone lotion

Idrocortisone

Incortin-H

Incortin-hydrogen

JUNGLE FOR

Kendall's compound F

Komed HC

Kyypakkaus

Lacticare HC

Lacticare-HC

Lactisona

Locoid

Lubricort

Maintasone

Medicort

Meusicort

Micort-HC

Mildison

MILDISON LIPOCREAM

Milliderm

neo-Cort-dome

neo-Cortef

Neosporin-H ear

Nogenic HC

NSC-10483

Nutracort

NYBADEX

Nystaform-HC

Ophthocort

Optef

Otalgine

Otic-neo-cort-dome

Otobiotic

Otocort

OTOSEPTIL

Otosone-F

OTOSPORIN

Pediotic suspension

Penecort

PERINAL

Permicort

Plenadren

Polcort H

Preparation H hydrocortisone cream

Prepcort

Prestwick_265

Prevex HC

Proctocort

PROCTOCREAM HC

Proctofoam

PROCTOFOAM HC

PROCTOSEDYL

Protocort

QUINOCORT

Racet

Rectoid

Reichstein's substance m

Remederm HC

Sanatison

Scalpicin capilar

Schericur

Scheroson F

SENTIAL HC

Sigmacort

Signef

Stie-cort

Stiefcorcil

Synacort

Systral hydrocort

Tarcortin

Terra-cortril

TERRA-CORTRIL NYSTATIN

Texacort

Timocort

TIMODINE

Topicort

TOPISONE

Transderma H

Traumaide

TRI-CICATRIN

U-cort

Uniderm

UNIROID

UNIROID HC

Vioform-hydrocortisone

VoSol HC

Vytone

XYLOPROCT

Zenoxone

β-HC

7

Tetracosactide

Approved

Phase 1

16960-16-0

16133802 16129617

8

Epinephryl borate

Phase 1

9

Melanocyte-Stimulating Hormones

Phase 1

10

Adrenocorticotropic Hormone

Phase 1

11

beta-Endorphin

Phase 1

12

Neurotransmitter Agents

Phase 1

13

Hormones

Phase 1

14

Hormone Antagonists

Phase 1

15

Hydrocortisone 17-butyrate 21-propionate

Phase 1

16

Endorphins

Phase 1

Interventional clinical trials:

#	Name	Status	NCT ID	Phase	Drugs
1	Adrenal Responsiveness During the Perioperative Period in Children Undergoing Congenital Cardiac Surgery	Completed	NCT01839812	Phase 1	Cosyntropin
2	Expression of Different Proliferation Biomarkers in Adreno-cortical Tumors	Unknown status	NCT02747355
3	The Effects of Case Management in a Medicaid Managed Care Plan	Unknown status	NCT00385879

Search NIH Clinical Center for Adrenal Cortex Disease

Cochrane evidence based reviews: adrenal cortex diseases

Sources

Genetic Tests for Adrenal Cortex Disease

Sources

Anatomical Context for Adrenal Cortex Disease

Organs/tissues related to Adrenal Cortex Disease:

MalaCards : Adrenal Cortex, Cortex, Heart

Sources

Publications for Adrenal Cortex Disease

Articles related to Adrenal Cortex Disease:

#	Title	Authors	PMID	Year
1	Tips for management of arrhythmias in endocrine disorders from an European Heart Rhythm Association position paper. ⁶²	Ozcan EE...Gorenek B	30297583	2018
2	Hypertension and adrenal cortex disease. A review of 100 autopsied cases. ⁶²	Ludwig RN	5491407	1970

Sources

Genes for Adrenal Cortex Disease

Genes related to Adrenal Cortex Disease (0 elite genes):

(show all 49)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	MIR483	MicroRNA 483	RNA Gene	12.19	DISEASES inferred ¹⁴ ¹⁴
2	POMC	Proopiomelanocortin	Protein Coding	8.95	DISEASES inferred ¹⁴
3	MIR139	MicroRNA 139	RNA Gene	8.67	DISEASES inferred ¹⁴ ¹⁴
4	NR0B1	Nuclear Receptor Subfamily 0 Group B Member 1	Protein Coding	8.15	DISEASES inferred ¹⁴
5	PRKAR1A	Protein Kinase CAMP-Dependent Type I Regulatory Subunit Alpha	Protein Coding	7.93	DISEASES inferred ¹⁴
6	AIRE	Autoimmune Regulator	Protein Coding	7.77	DISEASES inferred ¹⁴
7	MIR675	MicroRNA 675	RNA Gene	7.65	DISEASES inferred ¹⁴ ¹⁴
8	CCR6	C-C Motif Chemokine Receptor 6	Protein Coding	7.65	DISEASES inferred ¹⁴ ¹⁴
9	NUDT10	Nudix Hydrolase 10	Protein Coding	7.62	DISEASES inferred ¹⁴
10	EPPIN	Epididymal Peptidase Inhibitor	Protein Coding	7.6	DISEASES inferred ¹⁴ ¹⁴
11	NR5A1	Nuclear Receptor Subfamily 5 Group A Member 1	Protein Coding	7.39	DISEASES inferred ¹⁴
12	TP53	Tumor Protein P53	Protein Coding	7.24	DISEASES inferred ¹⁴
13	CYP11B1	Cytochrome P450 Family 11 Subfamily B Member 1	Protein Coding	7.11	DISEASES inferred ¹⁴
14	IGF2	Insulin Like Growth Factor 2	Protein Coding	7.08	DISEASES inferred ¹⁴
15	MC2R	Melanocortin 2 Receptor	Protein Coding	7.04	DISEASES inferred ¹⁴
16	CYP21A2	Cytochrome P450 Family 21 Subfamily A Member 2	Protein Coding	7	DISEASES inferred ¹⁴
17	CYP11B2	Cytochrome P450 Family 11 Subfamily B Member 2	Protein Coding	7	DISEASES inferred ¹⁴
18	CRH	Corticotropin Releasing Hormone	Protein Coding	6.92	DISEASES inferred ¹⁴
19	CYP11A1	Cytochrome P450 Family 11 Subfamily A Member 1	Protein Coding	6.91	DISEASES inferred ¹⁴
20	PDE11A	Phosphodiesterase 11A	Protein Coding	6.91	DISEASES inferred ¹⁴
21	MLANA	Melan-A	Protein Coding	6.9	DISEASES inferred ¹⁴
22	REN	Renin	Protein Coding	6.85	DISEASES inferred ¹⁴
23	MIR101-1	MicroRNA 101-1	RNA Gene	6.81	DISEASES inferred ¹⁴ ¹⁴
24	MEN1	Menin 1	Protein Coding	6.69	DISEASES inferred ¹⁴
25	CTNNB1	Catenin Beta 1	Protein Coding	6.61	DISEASES inferred ¹⁴
26	CYP17A1	Cytochrome P450 Family 17 Subfamily A Member 1	Protein Coding	6.6	DISEASES inferred ¹⁴
27	PTPN22	Protein Tyrosine Phosphatase Non-Receptor Type 22	Protein Coding	6.59	DISEASES inferred ¹⁴
28	ZNRF3	Zinc And Ring Finger 3	Protein Coding	6.59	DISEASES inferred ¹⁴
29	TNFRSF25	TNF Receptor Superfamily Member 25	Protein Coding	6.54	DISEASES inferred ¹⁴
30	ICOSLG	Inducible T Cell Costimulator Ligand	Protein Coding	6.53	DISEASES inferred ¹⁴ ¹⁴
31	INS	Insulin	Protein Coding	6.49	DISEASES inferred ¹⁴
32	PDE8B	Phosphodiesterase 8B	Protein Coding	6.46	DISEASES inferred ¹⁴
33	ARMC5	Armadillo Repeat Containing 5	Protein Coding	6.42	DISEASES inferred ¹⁴
34	SYP	Synaptophysin	Protein Coding	6.41	DISEASES inferred ¹⁴
35	TPO	Thyroid Peroxidase	Protein Coding	6.33	DISEASES inferred ¹⁴
36	HSD3B2	Hydroxy-Delta-5-Steroid Dehydrogenase, 3 Beta- And Steroid Delta-Isomerase 2	Protein Coding	6.33	DISEASES inferred ¹⁴
37	STAR	Steroidogenic Acute Regulatory Protein	Protein Coding	6.32	DISEASES inferred ¹⁴
38	TG	Thyroglobulin	Protein Coding	6.29	DISEASES inferred ¹⁴
39	KCNJ5	Potassium Inwardly Rectifying Channel Subfamily J Member 5	Protein Coding	6.28	DISEASES inferred ¹⁴
40	ABCD1	ATP Binding Cassette Subfamily D Member 1	Protein Coding	6.24	DISEASES inferred ¹⁴
41	CTLA4	Cytotoxic T-Lymphocyte Associated Protein 4	Protein Coding	6.22	DISEASES inferred ¹⁴
42	TOR1A	Torsin Family 1 Member A	Protein Coding	6.22	DISEASES inferred ¹⁴
43	IGF1R	Insulin Like Growth Factor 1 Receptor	Protein Coding	6.21	DISEASES inferred ¹⁴
44	CD8A	CD8a Molecule	Protein Coding	6.15	DISEASES inferred ¹⁴
45	PRL	Prolactin	Protein Coding	6.12	DISEASES inferred ¹⁴
46	H2AC18	H2A Clustered Histone 18	Protein Coding	6.12	DISEASES inferred ¹⁴ ¹⁴
47	NR3C1	Nuclear Receptor Subfamily 3 Group C Member 1	Protein Coding	6.1	DISEASES inferred ¹⁴
48	HSD3B1	Hydroxy-Delta-5-Steroid Dehydrogenase, 3 Beta- And Steroid Delta-Isomerase 1	Protein Coding	6.09	DISEASES inferred ¹⁴
49	SOAT1	Sterol O-Acyltransferase 1	Protein Coding	6.07	DISEASES inferred ¹⁴

Sources

Variations for Adrenal Cortex Disease

Sources

Expression for Adrenal Cortex Disease

Search GEO for disease gene expression data for Adrenal Cortex Disease.

Sources

Pathways for Adrenal Cortex Disease

Pathways related to Adrenal Cortex Disease according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Diseases of glycosylation ⁶⁶ Show member pathways Defective ALG1 causes CDG-1k ⁶⁶ Defective ALG11 causes CDG-1p ⁶⁶ Defective ALG12 causes CDG-1g ⁶⁶ Defective ALG14 causes ALG14-CMS ⁶⁶ Defective ALG2 causes CDG-1i ⁶⁶ Defective ALG3 causes CDG-1d ⁶⁶ Defective ALG6 causes CDG-1c ⁶⁶ Defective ALG8 causes CDG-1h ⁶⁶ Defective ALG9 causes CDG-1l ⁶⁶ Defective DPAGT1 causes CDG-1j, CMSTA2 ⁶⁶ Defective GNE causes sialuria, NK and IBM2 ⁶⁶ Defective MPDU1 causes CDG-1f ⁶⁶ Defective NEU1 causes sialidosis ⁶⁶ Defective RFT1 causes CDG-1n ⁶⁶ Diseases associated with glycosylation precursor biosynthesis ⁶⁶ Diseases associated with N-glycosylation of proteins ⁶⁶ Diseases of metabolism ⁶⁶ MPS IV - Morquio syndrome B ⁶⁶	12.45	POMC MC2R CYP21A2 CYP11B2 CYP11B1 CYP11A1
2	Oxidation by cytochrome P450 ⁷⁴ Show member pathways Amine Oxidase reactions ⁶⁶ Aryl hydrocarbon receptor signalling ⁶⁶ Atomoxetine Pathway, Pharmacokinetics ⁶⁰ Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB ⁶⁶ Celecoxib Pathway, Pharmacokinetics ⁶⁰ Cyclophosphamide Pathway, Pharmacokinetics ⁶⁰ CYP2E1 reactions ⁶⁶ Cytochrome P450 - arranged by substrate type ⁶⁶ Defective CYP24A1 causes HCAI ⁶⁶ Defective CYP26B1 causes RHFCA ⁶⁶ Defective CYP26C1 causes FFDD4 ⁶⁶ Defective CYP27A1 causes CTX ⁶⁶ Defective CYP27B1 causes VDDR1A ⁶⁶ Defective CYP27B1 causes VDDR1B ⁶⁶ Defective CYP4F22 causes ARCI5 ⁶⁶ Defective MAOA causes BRUNS ⁶⁶ Eicosanoids ⁶⁶ Endogenous sterols ⁶⁶ Ethanol oxidation ⁶⁶ Fatty acid omega-oxidation ⁷⁴ Fatty acids ⁶⁶ Fluvoxamine Pathway, Pharmacokinetics ⁶⁰ Lidocaine Pathway, Pharmacokinetics ⁶⁰ Miscellaneous substrates ⁶⁶ Phase I - Functionalization of compounds ⁶⁶ Prasugrel Pathway, Pharmacokinetics ⁶⁰ Sterols are 12-hydroxylated by CYP8B1 ⁶⁶ Vitamin D2 (ergocalciferol) metabolism ²² Vitamins ⁶⁶ Xenobiotics ⁶⁶	12.44	POMC CYP21A2 CYP11B2 CYP11B1 CYP11A1
3	Metabolism of steroids ⁶⁶ Show member pathways Activation of gene expression by SREBF (SREBP) ⁶⁶ allopregnanolone biosynthesis ⁶¹ androgen biosynthesis ⁶¹ Cholesterol synthesis disorders ⁷⁴ Defective CYP17A1 causes AH5 ⁶⁶ Regulation of cholesterol biosynthesis by SREBP (SREBF) ⁶⁶ Sterol regulatory element-binding proteins (SREBP) signaling ⁷⁴ Vitamin D (calciferol) metabolism ⁶⁶	12.33	POMC CYP21A2 CYP11B2 CYP11B1 CYP11A1
4	G alpha (s) signalling events ⁶⁶ Show member pathways Defective ACTH causes obesity and POMCD ⁶⁶	11.86	PRKAR1A POMC PDE11A MC2R CRH
5	Metabolism of steroid hormones ⁶⁶ Show member pathways Androgen biosynthesis ⁶⁶ Defective CYP11A1 causes AICSR ⁶⁶ Defective CYP11B1 causes AH4 ⁶⁶ Defective CYP21A2 causes AH3 ⁶⁶ Electron transport from NADPH to Ferredoxin ⁶⁶ Estrogen biosynthesis ⁶⁶ Glucocorticoid and Mineralcorticoid Metabolism ⁷⁴ Glucocorticoid biosynthesis ⁶⁶ Mineralocorticoid biosynthesis ⁶⁶ Pregnenolone biosynthesis ⁶⁶	11.34	POMC CYP21A2 CYP11B2 CYP11B1 CYP11A1
6	Metabolic disorders of biological oxidation enzymes ⁶⁶	10.99	CYP21A2 CYP11B2 CYP11B1 CYP11A1
7	Corticotropin-releasing hormone signaling pathway ⁷⁴	10.98	POMC CYP21A2 CYP11B1 CYP11A1 CRH
8	Classical pathway of steroidogenesis with glucocorticoid and mineralocorticoid metabolism ⁷⁴ Show member pathways Defective CYP11B2 causes CMO-1 deficiency ⁶⁶ progesterone biosynthesis ⁶¹	10.36	CYP11B2 CYP11A1
9	Glucocorticoid Pathway (HPA Axis), Pharmacodynamics ⁶⁰	10.28	POMC CRH

Sources

GO Terms for Adrenal Cortex Disease

Cellular components related to Adrenal Cortex Disease according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	sperm plasma membrane	GO:0097524	8.92	CCR6 EPPIN

Biological processes related to Adrenal Cortex Disease according to GeneCards Suite gene sharing:

(show all 13)

#	Name	GO ID	Score	Top Affiliating Genes
1	adrenal gland development	GO:0030325	9.91	NR5A1 NR0B1 CRH
2	steroid metabolic process	GO:0008202	9.85	CYP21A2 CYP11B2 CYP11B1 CYP11A1
3	cellular response to peptide hormone stimulus	GO:0071375	9.85	CYP11A1 CYP11B1 CYP11B2
4	Sertoli cell differentiation	GO:0060008	9.83	NR5A1 NR0B1
5	cortisol biosynthetic process	GO:0034651	9.8	CYP11B2 CYP11B1
6	aldosterone biosynthetic process	GO:0032342	9.78	CYP11B2 CYP11B1
7	sterol metabolic process	GO:0016125	9.76	CYP21A2 CYP11B2 CYP11B1 CYP11A1
8	C21-steroid hormone biosynthetic process	GO:0006700	9.73	CYP11B2 CYP11B1 CYP11A1
9	steroid biosynthetic process	GO:0006694	9.72	CYP21A2 CYP11B2 CYP11B1 CYP11A1
10	mineralocorticoid biosynthetic process	GO:0006705	9.71	CYP21A2 CYP11B2
11	sex determination	GO:0007530	9.69	NR5A1 NR0B1
12	cortisol metabolic process	GO:0034650	9.43	CYP11B2 CYP11B1 CYP11A1
13	glucocorticoid biosynthetic process	GO:0006704	9.32	CYP21A2 CYP11B2 CYP11B1 CYP11A1 CRH

Molecular functions related to Adrenal Cortex Disease according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	heme binding	GO:0020037	9.97	CYP21A2 CYP11B2 CYP11B1 CYP11A1
2	iron ion binding	GO:0005506	9.92	CYP21A2 CYP11B2 CYP11B1 CYP11A1
3	mRNA 3'-UTR binding	GO:0003730	9.8	TP53 MIR675 MIR483 MIR139
4	corticosterone 18-monooxygenase activity	GO:0047783	9.56	CYP11B2 CYP11B1
5	steroid 11-beta-monooxygenase activity	GO:0004507	9.46	CYP11B2 CYP11B1
6	monooxygenase activity	GO:0004497	9.26	CYP21A2 CYP11B2 CYP11B1 CYP11A1
7	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	GO:0016705	8.92	CYP21A2 CYP11B2 CYP11B1 CYP11A1

Sources

Sources for Adrenal Cortex Disease

¹ BitterDB

² CDC

³ Cell Signaling Technology

⁴ ClinicalTrials

⁵ ClinVar

⁶ CNVD

⁷ Cochrane Library

⁸ Cosmic

⁹ dbSNP

¹⁰ DGIdb

¹¹ Disease Ontology

¹² diseasecard

¹³ DiseaseEnhancer

¹⁴ DISEASES

¹⁵ DrugBank

¹⁶ EFO

¹⁷ ExPASy

¹⁸ FMA

¹⁹ GARD

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ GenomeRNAi

²⁶ GEO DataSets

²⁷ GO

²⁸ GTR

²⁹ HMDB

³⁰ HPO

³¹ ICD10

³² ICD10 via Orphanet

³³ ICD11

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ LifeMap

³⁷ LncRNADisease

³⁸ LOVD

³⁹ MalaCards

⁴⁰ MedGen

⁴¹ MedlinePlus

⁴² MedlinePlus Genetics

⁴³ MeSH

⁴⁴ MESH via Orphanet

⁴⁵ MGI

⁴⁶ miR2Disease

⁴⁷ NCBI Bookshelf

⁴⁸ NCI

⁴⁹ NCIt

⁵⁰ NDF-RT

⁵¹ NIH Clinical Center

⁵² NINDS

⁵³ Novoseek

⁵⁴ Novus Biologicals

⁵⁵ ODiseA

⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 08-Dec-2022)

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubChem

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ WikiPathways

⁷⁵ Wikipedia

MCID: ADR009 MIFTS: 33	Adrenal Cortex Disease Categories: Endocrine diseases	Data Licensing For inquiries, contact: [email protected]
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