MCID: ADR009
MIFTS: 33

Adrenal Cortex Disease

Categories: Endocrine diseases
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Aliases & Classifications for Adrenal Cortex Disease

MalaCards integrated aliases for Adrenal Cortex Disease:

Name: Adrenal Cortex Disease 11 14
Adrenal Cortex Diseases 43 71

Classifications:



External Ids:

Disease Ontology 11 DOID:3952
MeSH 43 D000303
SNOMED-CT 68 129636003
UMLS 71 C0001614

Summaries for Adrenal Cortex Disease

MalaCards based summary: Adrenal Cortex Disease, also known as adrenal cortex diseases, is related to primary pigmented nodular adrenocortical disease and familial glucocorticoid deficiency. An important gene associated with Adrenal Cortex Disease is MIR483 (MicroRNA 483), and among its related pathways/superpathways are Diseases of glycosylation and Oxidation by cytochrome P450. The drugs Racepinephrine and Dexamethasone acetate have been mentioned in the context of this disorder. Affiliated tissues include adrenal cortex, cortex and heart, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Reduced mammosphere formation

Related Diseases for Adrenal Cortex Disease

Diseases related to Adrenal Cortex Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 188)
# Related Disease Score Top Affiliating Genes
1 primary pigmented nodular adrenocortical disease 32.0 PRKAR1A POMC PDE11A MIR483 MC2R CYP11B2
2 familial glucocorticoid deficiency 32.0 POMC NR5A1 NR0B1 MC2R CYP21A2 CYP11B2
3 acute adrenal insufficiency 30.5 POMC CYP21A2 CYP11A1
4 pituitary-dependent cushing's disease 30.5 POMC MC2R CRH
5 conn's syndrome 29.7 TP53 PRKAR1A POMC PDE11A NR5A1 NR0B1
6 wissler-fanconi syndrome 10.5 POMC AIRE
7 hypoaldosteronism 10.5 POMC CYP11B2
8 cutaneous candidiasis 10.5 NUDT10 CCR6 AIRE
9 basophil adenoma 10.5 PRKAR1A POMC PDE11A
10 hypoglycemic coma 10.5 POMC IGF2 EPPIN
11 autoimmune gastritis 10.5 NUDT10 CCR6 AIRE
12 melanotic neurilemmoma 10.4 PRKAR1A POMC PDE11A
13 prolactin producing pituitary tumor 10.4 TP53 POMC
14 premature ovarian failure 7 10.4 POMC NR5A1 CRH
15 autoimmune polyendocrine syndrome type 1 10.4 NUDT10 CCR6 AIRE
16 glycerol kinase deficiency 10.4 POMC NR5A1 NR0B1
17 androgen insensitivity, partial 10.4 NR5A1 NR0B1 EPPIN
18 pernicious anemia 10.4 NUDT10 CCR6 AIRE
19 mixed gonadal dysgenesis 10.4 NR5A1 NR0B1 CYP21A2
20 islet cell tumor 10.4 POMC MIR483 IGF2
21 waterhouse-friderichsen syndrome 10.4 POMC MC2R CRH
22 acth-secreting pituitary adenoma 10.4 PRKAR1A POMC CRH
23 pituitary cancer 10.4 TP53 PRKAR1A POMC
24 nail disease 10.4 NUDT10 CCR6 AIRE
25 hair disease 10.4 POMC CCR6 AIRE
26 mediastinal lipomatosis 10.4 POMC CRH
27 apparent mineralocorticoid excess 10.4 POMC CYP11B2 CYP11B1
28 functioning pituitary adenoma 10.4 PRKAR1A POMC CRH
29 ectopic cushing syndrome 10.4 POMC CRH
30 acth-independent cushing syndrome 10.4 PRKAR1A PDE11A
31 breast ductal adenoma 10.4 PRKAR1A PDE11A
32 multiple endocrine neoplasia, type i 10.4 PRKAR1A POMC MIR483 MIR139
33 colorectal adenoma 10.4 TP53 MIR139 CCR6
34 thymus gland disease 10.4 TP53 CCR6 AIRE
35 autoimmune polyendocrine syndrome, type ii 10.4 POMC NUDT10 CCR6 AIRE
36 leydig cell hypoplasia 10.4 NR5A1 EPPIN CYP11A1
37 thymus cancer 10.4 TP53 CCR6 AIRE
38 persistent mullerian duct syndrome 10.4 NR5A1 NR0B1 CYP21A2
39 vitiligo-associated multiple autoimmune disease susceptibility 1 10.4 POMC CCR6 AIRE
40 autoimmune polyendocrine syndrome, type i, with or without reversible metaphyseal dysplasia 10.4 CYP21A2 CYP11A1 AIRE
41 45,x/46,xy mixed gonadal dysgenesis 10.4 NR5A1 NR0B1
42 intellectual developmental disorder, x-linked, syndromic, wilson-turner type 10.4 TP53 MIR483 IGF2
43 persistent fetal circulation syndrome 10.4 POMC IGF2 CRH
44 bone resorption disease 10.4 MIR675 MIR483 MIR139 CCR6
45 pre-malignant neoplasm 10.4 TP53 MIR139 CCR6
46 autoimmune disease of endocrine system 10.4 POMC NUDT10 CCR6 AIRE
47 cardiovascular organ benign neoplasm 10.4 TP53 MIR139 CCR6
48 adult syndrome 10.4 POMC IGF2 CRH
49 reproductive system disease 10.4 MIR483 MIR139 EPPIN CCR6
50 liddle syndrome 1 10.4 POMC CYP11B2 CYP11B1

Graphical network of the top 20 diseases related to Adrenal Cortex Disease:



Diseases related to Adrenal Cortex Disease

Symptoms & Phenotypes for Adrenal Cortex Disease

GenomeRNAi Phenotypes related to Adrenal Cortex Disease according to GeneCards Suite gene sharing:

25 (show all 30)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-100 10.21 CYP11A1 CYP21A2
2 Increased shRNA abundance (Z-score > 2) GR00366-A-102 10.21 NR5A1
3 Increased shRNA abundance (Z-score > 2) GR00366-A-105 10.21 CYP21A2
4 Increased shRNA abundance (Z-score > 2) GR00366-A-11 10.21 CYP11A1
5 Increased shRNA abundance (Z-score > 2) GR00366-A-12 10.21 TP53
6 Increased shRNA abundance (Z-score > 2) GR00366-A-120 10.21 CYP11A1 TP53
7 Increased shRNA abundance (Z-score > 2) GR00366-A-132 10.21 NR5A1 TP53
8 Increased shRNA abundance (Z-score > 2) GR00366-A-139 10.21 CYP21A2
9 Increased shRNA abundance (Z-score > 2) GR00366-A-145 10.21 CYP21A2
10 Increased shRNA abundance (Z-score > 2) GR00366-A-161 10.21 CYP21A2
11 Increased shRNA abundance (Z-score > 2) GR00366-A-166 10.21 CYP11A1
12 Increased shRNA abundance (Z-score > 2) GR00366-A-169 10.21 TP53
13 Increased shRNA abundance (Z-score > 2) GR00366-A-173 10.21 NR5A1
14 Increased shRNA abundance (Z-score > 2) GR00366-A-184 10.21 CYP11A1 CYP21A2 NR5A1 TP53
15 Increased shRNA abundance (Z-score > 2) GR00366-A-185 10.21 CYP21A2
16 Increased shRNA abundance (Z-score > 2) GR00366-A-19 10.21 TP53
17 Increased shRNA abundance (Z-score > 2) GR00366-A-190 10.21 TP53
18 Increased shRNA abundance (Z-score > 2) GR00366-A-20 10.21 TP53
19 Increased shRNA abundance (Z-score > 2) GR00366-A-202 10.21 NR5A1
20 Increased shRNA abundance (Z-score > 2) GR00366-A-203 10.21 CYP21A2
21 Increased shRNA abundance (Z-score > 2) GR00366-A-206 10.21 CYP21A2
22 Increased shRNA abundance (Z-score > 2) GR00366-A-208 10.21 CYP21A2
23 Increased shRNA abundance (Z-score > 2) GR00366-A-213 10.21 CYP21A2
24 Increased shRNA abundance (Z-score > 2) GR00366-A-35 10.21 TP53
25 Increased shRNA abundance (Z-score > 2) GR00366-A-39 10.21 TP53
26 Increased shRNA abundance (Z-score > 2) GR00366-A-42 10.21 CYP11A1 NR5A1
27 Increased shRNA abundance (Z-score > 2) GR00366-A-62 10.21 TP53
28 Increased shRNA abundance (Z-score > 2) GR00366-A-63 10.21 CYP21A2
29 Increased shRNA abundance (Z-score > 2) GR00366-A-8 10.21 CYP21A2
30 Reduced mammosphere formation GR00396-S 9.17 CCR6 CYP11B1 CYP21A2 IGF2 MC2R NR0B1

MGI Mouse Phenotypes related to Adrenal Cortex Disease:

45 (show all 12)
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.31 AIRE CCR6 CRH CYP11A1 CYP11B1 CYP11B2
2 nervous system MP:0003631 10.29 AIRE CCR6 CRH CYP11A1 CYP11B1 CYP11B2
3 growth/size/body region MP:0005378 10.25 AIRE CRH CYP11A1 CYP11B1 CYP11B2 CYP21A2
4 endocrine/exocrine gland MP:0005379 10.21 AIRE CRH CYP11A1 CYP11B1 CYP11B2 EPPIN
5 liver/biliary system MP:0005370 10.13 AIRE CRH CYP11A1 CYP11B1 CYP11B2 IGF2
6 renal/urinary system MP:0005367 10.1 CRH CYP11B1 CYP11B2 EPPIN IGF2 POMC
7 behavior/neurological MP:0005386 10.07 AIRE CRH CYP11A1 CYP11B1 CYP11B2 CYP21A2
8 cardiovascular system MP:0005385 10.06 CCR6 CYP11A1 CYP11B1 CYP11B2 EPPIN IGF2
9 adipose tissue MP:0005375 10 CRH CYP11B1 CYP11B2 MC2R POMC PRKAR1A
10 immune system MP:0005387 10 AIRE CCR6 CRH CYP11A1 CYP11B1 CYP11B2
11 reproductive system MP:0005389 9.73 AIRE CYP11A1 CYP11B1 CYP11B2 EPPIN IGF2
12 hematopoietic system MP:0005397 9.47 AIRE CCR6 CRH CYP11A1 CYP11B1 CYP11B2

Drugs & Therapeutics for Adrenal Cortex Disease

Drugs for Adrenal Cortex Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 16)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Racepinephrine Approved, Vet_approved Phase 1 51-43-4, 329-65-7 838 5816
2
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 1 1177-87-3 3680
3
Dexamethasone Approved, Investigational, Vet_approved Phase 1 50-02-2 3003 5743
4
Hydrocortisone succinate Approved Phase 1 2203-97-6 3643
5
Hydrocortisone acetate Approved, Vet_approved Phase 1 50-03-3
6
Hydrocortisone Approved, Vet_approved Phase 1 50-23-7 3640 5754
7
Tetracosactide Approved Phase 1 16960-16-0 16133802 16129617
8 Epinephryl borate Phase 1
9 Melanocyte-Stimulating Hormones Phase 1
10 Adrenocorticotropic Hormone Phase 1
11
beta-Endorphin Phase 1
12 Neurotransmitter Agents Phase 1
13 Hormones Phase 1
14 Hormone Antagonists Phase 1
15 Hydrocortisone 17-butyrate 21-propionate Phase 1
16 Endorphins Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Adrenal Responsiveness During the Perioperative Period in Children Undergoing Congenital Cardiac Surgery Completed NCT01839812 Phase 1 Cosyntropin
2 Expression of Different Proliferation Biomarkers in Adreno-cortical Tumors Unknown status NCT02747355
3 The Effects of Case Management in a Medicaid Managed Care Plan Unknown status NCT00385879

Search NIH Clinical Center for Adrenal Cortex Disease

Cochrane evidence based reviews: adrenal cortex diseases

Genetic Tests for Adrenal Cortex Disease

Anatomical Context for Adrenal Cortex Disease

Organs/tissues related to Adrenal Cortex Disease:

MalaCards : Adrenal Cortex, Cortex, Heart

Publications for Adrenal Cortex Disease

Articles related to Adrenal Cortex Disease:

# Title Authors PMID Year
1
Tips for management of arrhythmias in endocrine disorders from an European Heart Rhythm Association position paper. 62
30297583 2018
2
Hypertension and adrenal cortex disease. A review of 100 autopsied cases. 62
5491407 1970

Variations for Adrenal Cortex Disease

Expression for Adrenal Cortex Disease

Search GEO for disease gene expression data for Adrenal Cortex Disease.

Pathways for Adrenal Cortex Disease

Pathways related to Adrenal Cortex Disease according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.45 POMC MC2R CYP21A2 CYP11B2 CYP11B1 CYP11A1
2
Show member pathways
12.44 POMC CYP21A2 CYP11B2 CYP11B1 CYP11A1
3
Show member pathways
12.33 POMC CYP21A2 CYP11B2 CYP11B1 CYP11A1
4
Show member pathways
11.86 PRKAR1A POMC PDE11A MC2R CRH
5
Show member pathways
11.34 POMC CYP21A2 CYP11B2 CYP11B1 CYP11A1
6 10.99 CYP21A2 CYP11B2 CYP11B1 CYP11A1
7 10.98 POMC CYP21A2 CYP11B1 CYP11A1 CRH
8
Show member pathways
10.36 CYP11B2 CYP11A1
9 10.28 POMC CRH

GO Terms for Adrenal Cortex Disease

Cellular components related to Adrenal Cortex Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 sperm plasma membrane GO:0097524 8.92 CCR6 EPPIN

Biological processes related to Adrenal Cortex Disease according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 adrenal gland development GO:0030325 9.91 NR5A1 NR0B1 CRH
2 steroid metabolic process GO:0008202 9.85 CYP21A2 CYP11B2 CYP11B1 CYP11A1
3 cellular response to peptide hormone stimulus GO:0071375 9.85 CYP11A1 CYP11B1 CYP11B2
4 Sertoli cell differentiation GO:0060008 9.83 NR5A1 NR0B1
5 cortisol biosynthetic process GO:0034651 9.8 CYP11B2 CYP11B1
6 aldosterone biosynthetic process GO:0032342 9.78 CYP11B2 CYP11B1
7 sterol metabolic process GO:0016125 9.76 CYP21A2 CYP11B2 CYP11B1 CYP11A1
8 C21-steroid hormone biosynthetic process GO:0006700 9.73 CYP11B2 CYP11B1 CYP11A1
9 steroid biosynthetic process GO:0006694 9.72 CYP21A2 CYP11B2 CYP11B1 CYP11A1
10 mineralocorticoid biosynthetic process GO:0006705 9.71 CYP21A2 CYP11B2
11 sex determination GO:0007530 9.69 NR5A1 NR0B1
12 cortisol metabolic process GO:0034650 9.43 CYP11B2 CYP11B1 CYP11A1
13 glucocorticoid biosynthetic process GO:0006704 9.32 CYP21A2 CYP11B2 CYP11B1 CYP11A1 CRH

Molecular functions related to Adrenal Cortex Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 heme binding GO:0020037 9.97 CYP21A2 CYP11B2 CYP11B1 CYP11A1
2 iron ion binding GO:0005506 9.92 CYP21A2 CYP11B2 CYP11B1 CYP11A1
3 mRNA 3'-UTR binding GO:0003730 9.8 TP53 MIR675 MIR483 MIR139
4 corticosterone 18-monooxygenase activity GO:0047783 9.56 CYP11B2 CYP11B1
5 steroid 11-beta-monooxygenase activity GO:0004507 9.46 CYP11B2 CYP11B1
6 monooxygenase activity GO:0004497 9.26 CYP21A2 CYP11B2 CYP11B1 CYP11A1
7 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen GO:0016705 8.92 CYP21A2 CYP11B2 CYP11B1 CYP11A1

Sources for Adrenal Cortex Disease

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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