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MCID: ADR041
MIFTS: 43

Adrenal Cortical Adenoma

Categories: Cancer diseases, Endocrine diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Adrenal Cortical Adenoma

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MalaCards integrated aliases for Adrenal Cortical Adenoma:

Name: Adrenal Cortical Adenoma 12 15 71
Adrenocortical Adenoma 12 17
Adenoma Adrenocortical 54

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Endocrine diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:0050891
UMLS 71 C0206667
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Summaries for Adrenal Cortical Adenoma

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Disease Ontology : 12 An adrenal adenoma that is a benign tumor of the adrenal cortex.

MalaCards based summary : Adrenal Cortical Adenoma, also known as adrenocortical adenoma, is related to gynecomastia and acth-independent cushing syndrome. An important gene associated with Adrenal Cortical Adenoma is SYP (Synaptophysin), and among its related pathways/superpathways are Cytochrome P450 - arranged by substrate type and Aldosterone synthesis and secretion. The drugs Etomidate and Autonomic Agents have been mentioned in the context of this disorder. Affiliated tissues include pituitary, cortex and adrenal cortex, and related phenotypes are Reduced mammosphere formation and behavior/neurological

Wikipedia : 74 Adrenocortical Adenoma (ACA) is commonly described as a benign neoplasm emerging from the cells that... more...

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Related Diseases for Adrenal Cortical Adenoma

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Diseases related to Adrenal Cortical Adenoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 342)
# Related Disease Score Top Affiliating Genes
1 gynecomastia 30.7 POMC INHA CYP21A2
2 acth-independent cushing syndrome 30.7 PRKAR1A CYP21A2 CYP11B1
3 gangliocytoma 30.6 SYP POMC CHGA
4 adrenogenital syndrome 30.5 SYP INHA CYP21A2
5 adenoma 30.4 REN PRKAR1A POMC MEN1 CYP21A2 CYP11B1
6 amenorrhea 30.4 POMC NR5A1 CYP17A1
7 hypokalemia 30.4 REN POMC CYP17A1 CYP11B1
8 conn's syndrome 30.4 SULT2A1 REN PRKAR1A POMC MEN1 MC2R
9 cellular ependymoma 30.4 SYP MEN1
10 liddle syndrome 1 30.4 REN POMC CYP11B1
11 pseudohermaphroditism 30.4 POMC NR5A1 CYP17A1
12 familial glucocorticoid deficiency 30.3 REN POMC MC2R
13 granular cell tumor 30.2 SYP MLANA INHA
14 hyperandrogenism 30.2 POMC IGF2 CYP21A2 CYP17A1 CYP11A1
15 adrenal adenoma 30.0 SULT2A1 REN PRKAR1A POMC MIR483 MEN1
16 hyperparathyroidism 30.0 PRKAR1A MEN1 CHGA
17 paraganglioma 30.0 SYP MEN1 CHGA
18 carcinoid syndrome 29.9 SYP MEN1 CHGA
19 parathyroid adenoma 29.9 PRKAR1A MEN1 CHGA
20 pheochromocytoma 29.9 SYP REN POMC MEN1 IGF2 CHGA
21 hemangioma 29.9 SYP MEN1 IGF2 CHGA
22 acromegaly 29.7 PRKAR1A POMC MEN1 IGF2
23 primary hyperparathyroidism 29.7 PRKAR1A POMC MEN1 CHGA
24 polycystic ovary syndrome 29.6 SULT2A1 POMC IGF2 CYP21A2 CYP17A1 CYP11A1
25 leydig cell tumor 29.6 SYP NR5A1 INHA CYP21A2 CYP17A1 CYP11A1
26 pituitary adenoma 29.6 PRKAR1A POMC MEN1 CHGA
27 beckwith-wiedemann syndrome 29.5 PRKAR1A MIR483 MEN1 IGF2
28 pituitary adenoma, prolactin-secreting 29.5 PRKAR1A POMC NR5A1 MEN1 CHGA
29 lipoid congenital adrenal hyperplasia 29.5 REN POMC NR5A1 MC2R CYP21A2 CYP17A1
30 meningioma, familial 29.5 SYP PRKAR1A POMC MLANA MEN1 IGF2
31 gastrointestinal stromal tumor 29.4 SYP MEN1 IGF2 CHGA
32 adrenocortical carcinoma, hereditary 29.2 PRKAR1A NR5A1 MIR483 MC2R IGF2 CYP17A1
33 carney complex variant 29.2 PRKAR1A POMC MLANA MEN1 MC2R CYP11B1
34 multiple endocrine neoplasia, type i 29.1 SYP PRKAR1A POMC MIR483 MEN1 CHGA
35 primary pigmented nodular adrenocortical disease 28.9 SYP PRKAR1A POMC MIR483 MEN1 MC2R
36 hypertension, essential 28.7 REN POMC MIR483 MEN1 CYP17A1 CYP11B1
37 adrenal cortical carcinoma 26.6 SYP REN PRKAR1A POMC NR5A1 MLANA
38 adrenal carcinoma 26.4 SYP REN PRKAR1A POMC NR5A1 MLANA
39 basophil adenoma 10.6 PRKAR1A POMC
40 breast ductal adenoma 10.5 PRKAR1A POMC
41 waterhouse-friderichsen syndrome 10.5 POMC MC2R
42 adrenal gland pheochromocytoma 10.5
43 hypoaldosteronism 10.5 REN POMC
44 classic congenital adrenal hyperplasia due to 21-hydroxylase deficiency 10.5 POMC CYP21A2
45 glomangiosarcoma 10.5 SYP MLANA
46 glucocorticoid deficiency 1 10.5 POMC MC2R
47 ureter small cell carcinoma 10.5 SYP CHGA
48 mature teratoma of the ovary 10.5 SYP MLANA
49 primary hepatic neuroendocrine carcinoma 10.4 SYP CHGA
50 ovarian cystic teratoma 10.4 SYP MLANA

Graphical network of the top 20 diseases related to Adrenal Cortical Adenoma:



Diseases related to Adrenal Cortical Adenoma
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Symptoms & Phenotypes for Adrenal Cortical Adenoma

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GenomeRNAi Phenotypes related to Adrenal Cortical Adenoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Reduced mammosphere formation GR00396-S 9.23 CHGA CYP11B1 CYP21A2 GIPR IGF2 MC2R

MGI Mouse Phenotypes related to Adrenal Cortical Adenoma:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.21 CYP11A1 CYP11B1 CYP17A1 CYP21A2 IGF2 MC2R
2 cardiovascular system MP:0005385 10.18 CHGA CYP11A1 CYP11B1 CYP17A1 IGF2 INHA
3 growth/size/body region MP:0005378 10.13 CHGA CYP11A1 CYP11B1 CYP17A1 IGF2 INHA
4 endocrine/exocrine gland MP:0005379 10.11 CHGA CYP11A1 CYP11B1 GIPR IGF2 INHA
5 homeostasis/metabolism MP:0005376 10.1 CHGA CYB5A CYP11A1 CYP11B1 CYP17A1 GIPR
6 mortality/aging MP:0010768 9.8 CHGA CYP11A1 CYP11B1 CYP17A1 CYP21A2 IGF2
7 liver/biliary system MP:0005370 9.7 CYB5A CYP11A1 IGF2 INHA MEN1 POMC
8 reproductive system MP:0005389 9.28 CHGA CYP11A1 CYP17A1 IGF2 INHA MEN1
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Drugs & Therapeutics for Adrenal Cortical Adenoma

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Drugs for Adrenal Cortical Adenoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 57)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Etomidate Approved Phase 3 33125-97-2 36339 667484
2 Autonomic Agents Phase 3
3 Sympathomimetics Phase 3
4 Neurotransmitter Agents Phase 3
5 Adrenergic Agonists Phase 3
6 Respiratory System Agents Phase 3
7 Anti-Asthmatic Agents Phase 3
8 Vasoconstrictor Agents Phase 3
9 Adrenergic beta-Agonists Phase 3
10 Adrenergic Agents Phase 3
11 Bronchodilator Agents Phase 3
12 Mydriatics Phase 3
13 Fluorodeoxyglucose F18 Phase 3
14 Anesthetics Phase 3
15 Anesthetics, General Phase 3
16 Hypnotics and Sedatives Phase 3
17 Central Nervous System Depressants Phase 3
18 Anesthetics, Intravenous Phase 3
19 Adrenocorticotropic Hormone Phase 2
20 Antiemetics Phase 2
21 HIV Protease Inhibitors Phase 2
22
protease inhibitors Phase 2
23 Gastrointestinal Agents Phase 2
24 Antineoplastic Agents, Hormonal Phase 2
25 glucocorticoids Phase 2
26
Dopamine Approved 51-61-6, 62-31-7 681
27
Ethanol Approved 64-17-5 702
28
Indapamide Approved 26807-65-8 3702
29
Amlodipine Approved 88150-42-9 2162
30
Diltiazem Approved, Investigational 42399-41-7 39186
31
Angiotensin II Approved, Investigational 68521-88-0, 4474-91-3, 11128-99-7 172198
32
Spironolactone Approved 1952-01-7, 52-01-7 5833
33
Bisoprolol Approved 66722-44-9 2405
34
Prazosin Approved 19216-56-9 4893
35
Epinephrine Approved, Vet_approved 51-43-4 5816
36
Racepinephrine Approved 329-65-7 838
37
Dexamethasone acetate Approved, Investigational, Vet_approved 1177-87-3
38
Hydrocortisone acetate Approved, Vet_approved 50-03-3
39
Dexamethasone Approved, Investigational, Vet_approved 50-02-2 5743
40
Hydrocortisone Approved, Vet_approved 50-23-7 5754
41 Dopamine Agents
42 Protective Agents
43 Hypoglycemic Agents
44 insulin
45 Insulin, Globin Zinc
46 Antihypertensive Agents
47 Giapreza
48 Angiotensin-Converting Enzyme Inhibitors
49 Angiotensinogen
50 Epinephryl borate

Interventional clinical trials:

(show all 19)
# Name Status NCT ID Phase Drugs
1 Combined 18F-Fluorodeoxyglucose (FDG) Positron Emission Tomography (PET) and 123I-Iodometomidate (123I-IMTO) Imaging for Adrenal Neoplasia Recruiting NCT02010957 Phase 3
2 A Phase II, Open-label, Dose Titration, Multi-center Study to Assess the Safety/Tolerability and Efficacy of Osilodrostat in Patients With All Types of Endogenous Cushing's Syndrome Except Cushing's Disease Completed NCT02468193 Phase 2 Osilodrostat
3 A Multicenter Medical Safety Follow-up Study for Patients With Partial Onset Seizures Who Received More Than 28 Days of Total Exposure to BGG492 in Studies CBGG492A2207 and/or CBGG492A2212 Completed NCT02150213 Phase 2 BGG492
4 Laparoscopic Adrenalectomy Versus Radiofrequency Ablation for Aldosterone-producing Adenoma: a Prospective Randomized Controlled Trial Unknown status NCT02030587
5 Expression of D2-Like Dopamine Receptor of Human Aldosterone-Producing Adenoma and Its Role in Regulation of Aldosterone Secretion and Cell Proliferation Unknown status NCT00173446
6 Evaluation of the Diagnostic Utility of Serum Dexamethasone Measurements in the Overnight 1mg Dexamethasone Suppression Test in Patients Investigated for Cushing's Syndrome and Incidentalomas Unknown status NCT01504555
7 Radiofrequency Ablation for Aldosterone-producting Adenoma in Patients With Primary Aldosteronism: Evaluation of the Blood Pressure Control and of Its Safety. Completed NCT02756754
8 Prevention of Conversion in Posterior Retroperitoneal Adrenalectomy by Measuring Preoperative Anatomical Conditions on Cross-sectional Imaging (CT or MRI) Completed NCT04071561
9 Is There Anything New in the Field of Large Adrenal Tumors ? Completed NCT03830593
10 Complex Cystic Benign Adrenal Incidentalomas Mimicking Non-adenomatous Masses; Rare Pathologies: Clinical Features and Outcomes. Case Series With Short Review of Literature. Completed NCT03739918
11 Cardiovascular Risk in Patients With Non-Functional Adrenal Incidentaloma: Myth or Reality? Completed NCT00768365
12 Effect of Chronic Catecholamine Overproduction on Brown Adipose Tissue Recruiting NCT01949714
13 Long-term Effects of Adrenalectomy on Metabolic Syndrome, Glucose Metabolism, Lipid Metabolism, and Bone Metabolism in Subclinical Cushing's Syndrome of Adrenal Incidentaloma Recruiting NCT01382420
14 Feasibility Study of RadioFrequency Endoscopic ABlation, With ULtrasound Guidance, as a Non-surgical, Adrenal Sparing Treatment for Aldosterone-producing Adenomas Recruiting NCT03405025
15 Impact of Adrenal IncidenTalomas and Possible Autonomous Cortisol Secretion on Cardiovascular and Metabolic Alterations (ITACA Study) Recruiting NCT04127552
16 Structured Evaluation of adRENal Tumors Discovered Incidentally - Prospectively Investigating the Testing Yield Recruiting NCT02324647
17 Surgery of Subclinical Cortisol Secreting Adrenal Incidentalomas Recruiting NCT02364089 Standardized medical treatment of hypertension by SAHR
18 Morbidity and Mortality in Patients With Adrenal Incidentalomas With and Without Autonomous Cortisol Secretion Active, not recruiting NCT03919734
19 A Prospective Cohort Study for Patients With Adrenal Diseases Not yet recruiting NCT03474237

Search NIH Clinical Center for Adrenal Cortical Adenoma

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Genetic Tests for Adrenal Cortical Adenoma

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Anatomical Context for Adrenal Cortical Adenoma

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MalaCards organs/tissues related to Adrenal Cortical Adenoma:

40
Pituitary, Cortex, Adrenal Cortex, Adrenal Gland, Thyroid, Kidney, Lung
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Publications for Adrenal Cortical Adenoma

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Articles related to Adrenal Cortical Adenoma:

(show top 50) (show all 937)
# Title Authors PMID Year
1
Biallelic APC inactivation was responsible for functional adrenocortical adenoma in familial adenomatous polyposis with novel germline mutation of the APC gene: report of a case. 54 61
19684041 2009
2
Detection of somatic beta-catenin mutations in primary pigmented nodular adrenocortical disease (PPNAD). 54 61
18419788 2008
3
The role of immunohistochemistry in histopathological diagnostics of clinically "silent" incidentally detected adrenal masses. 54 61
18393131 2008
4
Unique association of non-functioning pheochromocytoma, ganglioneuroma, adrenal cortical adenoma, hepatic and vertebral hemangiomas in a patient with a new intronic variant in the VHL gene. 54 61
16483185 2005
5
Significance of inhibin in reproductive pathophysiology and current clinical applications. 54 61
15970011 2005
6
Myxoid adrenocortical adenoma with a pseudoglandular pattern. 54 61
15235911 2004
7
Analysis of somatic APC mutations in rare extracolonic tumors of patients with familial adenomatous polyposis coli. 54 61
15287021 2004
8
Primary hyperparathyroidism associatiated with aldosterone-producing adrenocortical adenoma and breast cancer: relation to MEN1 gene. 54 61
15168774 2004
9
[The expression of A103 and inhibin alpha in adrenocortical adenoma by high-throughput tissue microarray techniques]. 54 61
12910679 2003
10
Massive adrenocortical adenoma following long-term treatment of 21-hydroxylase deficiency. 54 61
11832743 2002
11
Immunoexpression of inhibin alpha-subunit in adrenal neoplasms. 54 61
11556749 2001
12
Expression of adrenocorticotropin receptor gene in adrenocortical adenomas from patients with Cushing syndrome: possible contribution for the autonomous production of cortisol. 54 61
11420487 2001
13
Food-dependent androgen and cortisol secretion by a gastric inhibitory polypeptide-receptor expressive adrenocortical adenoma leading to hirsutism and subclinical Cushing's syndrome: in vivo and in vitro studies. 54 61
11158012 2001
14
Virilizing adrenocortical adenoma: in vitro steroidogenesis, immunohistochemical studies of steroidogenic enzymes, and gene expression of corticotropin receptor. 54 61
10216530 1999
15
Gene expression and roles of angiotensin II type 1 and type 2 receptors in human adrenals. 54 61
9761377 1998
16
[Aberrant expression of the GIP (Gastric Inhibitory Polypeptide) receptor in an adrenal cortical adenoma responsible for a case of food-dependent Cushing's syndrome]. 54 61
10333644 1998
17
Aldosterone-producing adrenocortical adenoma complicated by chronic renal failure. Case report and review of the literature. 54 61
9845833 1998
18
Evaluation of plasma aldosterone to plasma renin activity ratio in patients with primary aldosteronism. 54 61
9249232 1997
19
Oestrogen producing adrenocortical adenoma: clinical, biochemical and immunohistochemical studies. 54 61
8977764 1996
20
Immunolocalization of dehydroepiandrosterone sulfotransferase in normal and pathologic human adrenal gland. 54 61
8751327 1995
21
Expression of a high molecular weight form of insulin-like growth factor II in a Beckwith-Wiedemann syndrome associated adrenocortical adenoma. 54 61
7621447 1995
22
In-vitro evidence for the regulation of 17,20-lyase activity by cytochrome b5 in adrenocortical adenomas from patients with Cushing's syndrome. 54 61
8137519 1994
23
Mechanism of abnormal production of adrenal androgens in patients with adrenocortical adenomas and carcinomas. 54 61
8288710 1994
24
Disordered expression of adrenal steroidogenic P450 mRNAs in incidentally discovered nonfunctioning adrenal adenoma. 54 61
1535042 1992
25
Decreased levels of steroid 21-hydroxylase [P450(c21)] and its mRNA in an adrenocortical adenoma associated with 21-hydroxylase deficiency. 54 61
2101789 1990
26
Endocrine activity of the "silent" adrenocortical adenoma is uncovered by response to corticotropin-releasing hormone. 54 61
2165544 1990
27
An Activating Variant in CTNNB1 is Associated with a Sclerosing Bone Dysplasia and Adrenocortical Neoplasia. 61
31970420 2020
28
Adrenalectomy for non-neuroblastic pathology in children. 61
31691026 2020
29
Endoplasmic Reticulum Chaperone Calmegin Is Upregulated in Aldosterone-Producing Adenoma and Associates With Aldosterone Production. 61
31865789 2020
30
Adrenocortical tumors have a distinct, long, non-coding RNA expression profile and LINC00271 is downregulated in malignancy. 61
31522749 2020
31
Adrenal Cortical Adenoma in the Spinal Canal: A Case Report and Review of the Literature. 61
31127594 2020
32
Metallothionein protein and minichromosome maintenance protein-2 expression in adrenocortical tumors. 61
31703800 2019
33
IGF2 role in adrenocortical carcinoma biology. 61
31378849 2019
34
Expression of FSCN1 and FOXM1 are associated with poor prognosis of adrenocortical carcinoma patients. 61
31783819 2019
35
A case report of idiopathic hyperaldosteronism characterized by bilateral adrenal adenoma. 61
31651844 2019
36
Gas Chromatography-Mass Spectrometry Analysis of Urinary Steroid Metabolomics for Detection of Early Signs of Adrenal Neoplasm Malignancy in Patients with Cushing's Syndrome. 61
31630306 2019
37
The Utrecht Score: A novel histopathological scoring system to assess the prognosis of dogs with cortisol-secreting adrenocortical tumours. 61
30860644 2019
38
Adrenal cortical adenoma: current update, imaging features, atypical findings, and mimics. 61
31529204 2019
39
Changes in total and acylated ghrelin levels during mitotane treatment in patients with adrenocortical carcinoma. 61
31169262 2019
40
Stathmin 1 is highly expressed and associated with survival outcome in malignant adrenocortical tumours. 61
31441020 2019
41
Presentation, Treatment, Histology, and Outcomes in Adrenal Medullary Hyperplasia Compared With Pheochromocytoma. 61
31384714 2019
42
Validity of discharge ICD-10 codes in detecting the etiologies of endogenous Cushing's syndrome. 61
31340196 2019
43
Laparoscopic Adrenalectomy: Two Years Experience at Bangabandhu Sheikh Mujib Medical University. 61
31391438 2019
44
Intrahepatic adrenocortical adenoma arising from adrenohepatic fusion mimicking hepatic malignancy: Two case reports. 61
31169702 2019
45
18-Oxocortisol Synthesis in Aldosterone-Producing Adrenocortical Adenoma and Significance of KCNJ5 Mutation Status. 61
31006333 2019
46
Adrenal Myelolipoma with Adrenocortical Adenoma Presenting with Hypertension Only. 61
31142427 2019
47
Tubulopapillary adrenocortical adenoma in a patient with familial adenomatous polyposis: a morphologic, ultrastructural, and molecular study. 61
30172912 2019
48
Comparison of plasma and urinary microRNA-483-5p for the diagnosis of adrenocortical malignancy. 61
30940435 2019
49
Expression profiles analysis identifies the values of carcinogenesis and the prognostic prediction of three genes in adrenocortical carcinoma. 61
30816525 2019
50
A successful pregnancy in a patient with secondary hypertension caused by adrenal adenoma: a case report. 61
30943935 2019
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Variations for Adrenal Cortical Adenoma

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Expression for Adrenal Cortical Adenoma

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Search GEO for disease gene expression data for Adrenal Cortical Adenoma.
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Pathways for Adrenal Cortical Adenoma

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Pathways related to Adrenal Cortical Adenoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Cytochrome P450 - arranged by substrate type 65
Show member pathways
 12.91 SULT2A1 POMC CYP21A2 CYP17A1 CYP11B1 CYP11A1
2
Aldosterone synthesis and secretion 36
Show member pathways
 12.33 POMC NR5A1 MEN1 MC2R CYP21A2 CYP17A1
3
Diseases of metabolism 65
Show member pathways
 11.58 POMC MC2R CYP11A1
4
Corticotropin-releasing hormone signaling pathway 1
11.52 SULT2A1 POMC CYP21A2 CYP11B1 CYP11A1
5
Steroid hormone biosynthesis 36
Show member pathways
 11.38 CYP21A2 CYP17A1 CYP11B1 CYP11A1
6
Androstenedione and testosterone biosynthesis and metabolism p.1 22
Show member pathways
 11.31 SULT2A1 CYP17A1 CYP11B1
7
Metabolism of steroid hormones 65
Show member pathways
 10.97 POMC CYP21A2 CYP17A1 CYP11B1 CYP11A1
8
superpathway of steroid hormone biosynthesis 1
Show member pathways
 10.84 CYP21A2 CYP17A1 CYP11B1
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GO Terms for Adrenal Cortical Adenoma

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Cellular components related to Adrenal Cortical Adenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 organelle membrane GO:0031090 8.8 CYP21A2 CYP17A1 CYB5A

Biological processes related to Adrenal Cortical Adenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 steroid metabolic process GO:0008202 9.71 SULT2A1 CYP21A2 CYP17A1 CYP11A1
2 male gonad development GO:0008584 9.63 REN NR5A1 INHA
3 sterol metabolic process GO:0016125 9.5 CYP21A2 CYP11B1 CYP11A1
4 steroid biosynthetic process GO:0006694 9.46 CYP21A2 CYP17A1 CYP11B1 CYP11A1
5 C21-steroid hormone biosynthetic process GO:0006700 9.43 CYP11B1 CYP11A1
6 cellular response to peptide hormone stimulus GO:0071375 9.43 MEN1 CYP11B1 CYP11A1
7 cortisol metabolic process GO:0034650 9.37 CYP11B1 CYP11A1
8 regulation of blood pressure GO:0008217 9.26 REN POMC CYP11B1 CHGA
9 glucocorticoid biosynthetic process GO:0006704 8.92 CYP21A2 CYP17A1 CYP11B1 CYP11A1

Molecular functions related to Adrenal Cortical Adenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 9.5 POMC INHA IGF2
2 iron ion binding GO:0005506 9.46 CYP21A2 CYP17A1 CYP11B1 CYP11A1
3 insulin-like growth factor receptor binding GO:0005159 9.26 REN IGF2
4 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen GO:0016705 9.26 CYP21A2 CYP17A1 CYP11B1 CYP11A1
5 heme binding GO:0020037 9.02 CYP21A2 CYP17A1 CYP11B1 CYP11A1 CYB5A
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Sources for Adrenal Cortical Adenoma

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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