MCID: ADR041
MIFTS: 43

Adrenal Cortical Adenoma

Categories: Cancer diseases, Endocrine diseases

Aliases & Classifications for Adrenal Cortical Adenoma

MalaCards integrated aliases for Adrenal Cortical Adenoma:

Name: Adrenal Cortical Adenoma 12 15 73
Adrenocortical Adenoma 12 29
Adenoma Adrenocortical 55

Classifications:



External Ids:

Disease Ontology 12 DOID:0050891
UMLS 73 C0206667

Summaries for Adrenal Cortical Adenoma

Disease Ontology : 12 An adrenal adenoma that is a benign tumor of the adrenal cortex.

MalaCards based summary : Adrenal Cortical Adenoma, also known as adrenocortical adenoma, is related to adrenal gland hyperfunction and conn's syndrome. An important gene associated with Adrenal Cortical Adenoma is SYP (Synaptophysin), and among its related pathways/superpathways are Cytochrome P450 - arranged by substrate type and Aldosterone synthesis and secretion. The drugs Epinephrine and Racepinephrine have been mentioned in the context of this disorder. Affiliated tissues include adrenal cortex, cortex and testes, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Related Diseases for Adrenal Cortical Adenoma

Diseases related to Adrenal Cortical Adenoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 64)
# Related Disease Score Top Affiliating Genes
1 adrenal gland hyperfunction 29.0 CYP21A2 GIPR POMC PRKAR1A
2 conn's syndrome 28.3 CYP11A1 CYP11B1 CYP17A1 CYP21A2 MC2R POMC
3 adrenal adenoma 28.2 CYP11A1 CYP11B1 CYP17A1 CYP21A2 GIPR MC2R
4 adenoma 10.6
5 spermatocele 10.5 NR5A1 SYP
6 sella turcica neoplasm 10.5 POMC SYP
7 tuberculum sellae meningioma 10.5 POMC SYP
8 central nervous system organ benign neoplasm 10.5 POMC SYP
9 myxosarcoma 10.4 PRKAR1A SYP
10 cervix small cell carcinoma 10.4 POMC SYP
11 hyperaldosteronism, familial, type i 10.4 CYP11B1 POMC
12 ectopic cushing syndrome 10.4 POMC SYP
13 sex cord-gonadal stromal tumor 10.3 NR5A1 SYP
14 classic congenital adrenal hyperplasia due to 21-hydroxylase deficiency 10.3 CYP21A2 POMC
15 glucocorticoid deficiency 1 10.2 MC2R POMC
16 endocrine organ benign neoplasm 10.2 CYP11B1 POMC
17 sertoli cell tumor 10.2 NR5A1 PRKAR1A SYP
18 organ system benign neoplasm 10.2 CYP11B1 POMC SYP
19 achalasia-addisonianism-alacrima syndrome 10.2 MC2R POMC
20 transsexualism 10.2 CYP17A1 CYP21A2
21 carney complex variant 10.1 POMC PRKAR1A
22 familial glucocorticoid deficiency 10.1 MC2R POMC
23 pheochromocytoma 10.1
24 primary pigmented nodular adrenocortical disease 10.1 POMC PRKAR1A SYP
25 adrenal cortex disease 10.1 CYP11B1 POMC PRKAR1A
26 adrenal gland disease 10.1 CYP11B1 POMC PRKAR1A
27 pituitary-dependent cushing's disease 10.0 CYP21A2 POMC
28 antley-bixler syndrome 10.0 CYP17A1 CYP21A2
29 cell type benign neoplasm 10.0 POMC SYP
30 female reproductive system disease 9.9 CYP17A1 NR5A1 POMC
31 hepatitis 9.9
32 angiosarcoma 9.9
33 ganglioneuroma 9.9
34 beckwith-wiedemann syndrome 9.8
35 multiple endocrine neoplasia, type i 9.8
36 renal cell carcinoma, nonpapillary 9.8
37 carney triad 9.8
38 hemangioma 9.8
39 tethered spinal cord syndrome 9.8
40 pancreatitis 9.8
41 adenomatoid tumor 9.8
42 type i 9.8
43 glucagonoma 9.8
44 multiple endocrine neoplasia 9.8
45 cytochrome p450 oxidoreductase deficiency 9.8 CYP17A1 CYP21A2 POMC
46 gonadal disease 9.8 NR5A1 POMC SULT2A1
47 hyperandrogenism 9.7 CYP17A1 CYP21A2 POMC
48 pseudohermaphroditism 9.6 CYP17A1 NR5A1
49 46 xy gonadal dysgenesis 9.6 CYP11A1 NR5A1
50 hypospadias 9.4 CYP11A1 CYP17A1 NR5A1

Graphical network of the top 20 diseases related to Adrenal Cortical Adenoma:



Diseases related to Adrenal Cortical Adenoma

Symptoms & Phenotypes for Adrenal Cortical Adenoma

GenomeRNAi Phenotypes related to Adrenal Cortical Adenoma according to GeneCards Suite gene sharing:

26 (show all 15)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-109 10.27 SULT2A1
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-139 10.27 CYP21A2
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-142 10.27 SULT2A1
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-145 10.27 CYP21A2
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-173 10.27 NR5A1
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-175 10.27 SULT2A1
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-184 10.27 CYP11A1 CYP21A2 NR5A1
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-203 10.27 CYP11A1 CYP21A2 SULT2A1
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-206 10.27 CYP21A2
10 Decreased shRNA abundance (Z-score < -2) GR00366-A-213 10.27 CYP21A2
11 Decreased shRNA abundance (Z-score < -2) GR00366-A-28 10.27 CYP11A1
12 Decreased shRNA abundance (Z-score < -2) GR00366-A-33 10.27 SULT2A1
13 Decreased shRNA abundance (Z-score < -2) GR00366-A-94 10.27 SULT2A1
14 Increased transferrin (TF) endocytosis GR00363-A 9.56 CYP11A1 CYP11B1 CYP21A2 GIPR MC2R POMC
15 Reduced mammosphere formation GR00396-S 9.02 CYP11B1 CYP21A2 GIPR MC2R POMC

MGI Mouse Phenotypes related to Adrenal Cortical Adenoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.76 CYP11A1 CYP11B1 CYP17A1 MC2R NR5A1 POMC
2 endocrine/exocrine gland MP:0005379 9.5 CYP11A1 CYP11B1 GIPR MC2R NR5A1 POMC
3 homeostasis/metabolism MP:0005376 9.23 CYP11A1 CYP11B1 CYP17A1 GIPR MC2R NR5A1

Drugs & Therapeutics for Adrenal Cortical Adenoma

Drugs for Adrenal Cortical Adenoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 62)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Epinephrine Approved, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 51-43-4 5816
2
Racepinephrine Approved Phase 4,Phase 3,Phase 2,Not Applicable 329-65-7 838
3 Adrenergic Agents Phase 4,Phase 3,Not Applicable
4 Adrenergic Agonists Phase 4,Phase 3,Not Applicable
5 Adrenergic alpha-Agonists Phase 4,Phase 3,Not Applicable
6 Adrenergic beta-Agonists Phase 4,Phase 3,Not Applicable
7 Anti-Asthmatic Agents Phase 4,Phase 3,Not Applicable
8 Autonomic Agents Phase 4,Phase 3,Phase 2,Not Applicable
9 Bronchodilator Agents Phase 4,Phase 3,Not Applicable
10 Epinephryl borate Phase 4,Phase 3,Phase 2,Not Applicable
11 Mydriatics Phase 4,Phase 3,Not Applicable
12 Neurotransmitter Agents Phase 4,Phase 3,Not Applicable
13 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Not Applicable
14 Respiratory System Agents Phase 4,Phase 3,Not Applicable
15 Vasoconstrictor Agents Phase 4,Phase 3,Not Applicable
16
Hydrocortisone Approved, Vet_approved Phase 3,Phase 2,Not Applicable 50-23-7 5754
17
Mifepristone Approved, Investigational Phase 3 84371-65-3 55245
18
Etomidate Approved Phase 3 33125-97-2 36339 667484
19 Adrenocorticotropic Hormone Phase 3,Phase 2
20 beta-endorphin Phase 3
21 Contraceptive Agents Phase 3
22 Contraceptives, Oral Phase 3
23 Contraceptives, Postcoital Phase 3
24 Cortisol succinate Phase 3,Phase 2,Not Applicable
25 Hormone Antagonists Phase 3,Phase 2
26 Hormones Phase 3,Phase 2
27 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3,Phase 2
28 Hydrocortisone 17-butyrate 21-propionate Phase 3,Phase 2,Not Applicable
29 Hydrocortisone acetate Phase 3,Phase 2,Not Applicable
30 Luteolytic Agents Phase 3
31 Melanocyte-Stimulating Hormones Phase 3
32 Anesthetics Phase 3
33 Anesthetics, General Phase 3
34 Anesthetics, Intravenous Phase 3
35 Central Nervous System Depressants Phase 3
36 Fluorodeoxyglucose F18 Phase 3
37 Hypnotics and Sedatives Phase 3
38
Dexamethasone Approved, Investigational, Vet_approved Phase 2 50-02-2 5743
39 Antiemetics Phase 2
40 Anti-Inflammatory Agents Phase 2,Not Applicable
41 Antineoplastic Agents, Hormonal Phase 2
42 BB 1101 Phase 2
43 Dexamethasone acetate Phase 2 1177-87-3
44 Gastrointestinal Agents Phase 2
45 glucocorticoids Phase 2
46 HIV Protease Inhibitors Phase 2
47
protease inhibitors Phase 2
48
Ethanol Approved 64-17-5 702
49
Menthol Approved 2216-51-5 16666
50
Amlodipine Approved Not Applicable 88150-42-9 2162

Interventional clinical trials:

(show all 25)
# Name Status NCT ID Phase Drugs
1 Influence of Synacthen Infusion on the Results of Adrenal Venous Sampling in Patient With Primary Aldosteronism Unknown status NCT02127840 Phase 4 Synacthen infusion during adrenal venous sampling
2 An Extension Study of CORLUX in the Treatment of Endogenous Cushing's Syndrome Completed NCT00936741 Phase 3 mifepristone
3 A Study of the Efficacy and Safety of CORLUX in the Treatment of Endogenous Cushing's Syndrome Completed NCT00569582 Phase 3 mifepristone
4 Combined FDG-PET and 123I-Iodometomidate Imaging for Adrenal Neoplasia Recruiting NCT02010957 Phase 3
5 Medical Safety Follow-up Study for Patients Who Received More Than 28 Days of Total Exposure to BGG492 Completed NCT02150213 Phase 2 BGG492
6 Study of Efficacy and Safety of Osilodrostat in Cushing's Syndrome Recruiting NCT02468193 Phase 2 Osilodrostat
7 Study to Evaluate CORT125134 in Patients With Cushing's Syndrome Active, not recruiting NCT02804750 Phase 2 CORT125134
8 Study of Adrenalectomy Versus Observation for Subclinical Hypercortisolism Terminated NCT02001051 Phase 2
9 Long-term Beneficial Metabolic Effects of Adrenalectomy in Subclinical Cushing's Syndrome of Adrenal Incidentaloma Unknown status NCT01382420 Not Applicable
10 Cardiovascular Risk in Patients With Non-Functional Adrenal Incidentaloma Completed NCT00768365
11 Comparison Between Posterior Retroperitoneoscopic Adrenalectomy and Laparoscopic Adrenalectomy Completed NCT01676025 Not Applicable
12 Surgery of Subclinical Cortisol Secreting Adrenal Incidentalomas Recruiting NCT02364089 Not Applicable Standardized medical treatment of hypertension by SAHR
13 Structured Evaluation of adRENal Tumors Discovered Incidentally - Prospectively Investigating the Testing Yield Recruiting NCT02324647
14 Radiofrequency Endoscopic Ablation With Ultrasound Guidance: a Non-surgical Treatment for Aldosterone-producing Adenomas Recruiting NCT03405025 Not Applicable
15 Radiofrequency Ablation for Aldosterone-producting Adenoma in Patients With Primary Aldosteronism Recruiting NCT02756754 Not Applicable
16 Effect of Chronic Catecholamine Overproduction on Brown Adipose Tissue Recruiting NCT01949714
17 Does Serum-DXM Increase Diagnostic Accuracy of the Overnight DXM Suppression Test in the Work-up of Cushing's Syndrome? Recruiting NCT01504555
18 Adrenalectomy Versus Follow-up in Patients With Subclinical Cushings Syndrome Recruiting NCT01246739 Not Applicable
19 Quality of Life, Fatigue and Cognitive, Affective and Emotional Dysfunction in Patients With Cushing's Syndrome Recruiting NCT03211624
20 Clinical and Molecular Characteristics of Primary Aldosteronism in Blacks Recruiting NCT03374215
21 Study of Adrenal Gland Tumors Recruiting NCT00005927
22 Laparoscopic Adrenalectomy Versus Radiofrequency Ablation Active, not recruiting NCT02030587 Not Applicable
23 Expression of Different Proliferation Biomarkers in Adreno-cortical Tumors Active, not recruiting NCT02747355
24 A Prospective Cohort Study for Patients With Adrenal Diseases Not yet recruiting NCT03474237
25 A Study to Confirm Recurrent or Persistent Cushing's Syndrome in Patients With Signs or Symptoms of Hypercortisolemia Terminated NCT00796783 Cushing's syndrome confirmation

Search NIH Clinical Center for Adrenal Cortical Adenoma

Genetic Tests for Adrenal Cortical Adenoma

Genetic tests related to Adrenal Cortical Adenoma:

# Genetic test Affiliating Genes
1 Adrenocortical Adenoma 29

Anatomical Context for Adrenal Cortical Adenoma

MalaCards organs/tissues related to Adrenal Cortical Adenoma:

41
Adrenal Cortex, Cortex, Testes, Adrenal Gland, Pituitary

Publications for Adrenal Cortical Adenoma

Articles related to Adrenal Cortical Adenoma:

(show all 36)
# Title Authors Year
1
Pheochromocytoma with Synchronous Ipsilateral Adrenal Cortical Adenoma. ( 28762170 )
2017
2
Spinal adrenal cortical adenoma associated with Beckwith-Wiedemann syndrome: case report and review of the literature. ( 28365908 )
2017
3
An Unusual Adrenal Cortical Nodule: Composite Adrenal Cortical Adenoma and Adenomatoid Tumor. ( 25861051 )
2015
4
Adrenal renal fusion confusion: a case report of an adrenal cortical adenoma with adrenal-renal fusion. ( 25757409 )
2015
5
Clinical and pathological analysis of 116 cases of adult adrenal cortical adenoma and literature review. ( 26064059 )
2015
6
Myxoid adrenal cortical adenoma in an infant: An unusual morphology. ( 26881659 )
2015
7
Cushing's syndrome during pregnancy caused by adrenal cortical adenoma: a case report and literature review. ( 26271293 )
2015
8
Epithelioid Angiosarcoma Arising in an Adrenal Cortical Adenoma: A Case Report and Review of the Literature. ( 24771258 )
2014
9
A Mimic of Sarcomatoid Adrenal Cortical Carcinoma: Epithelioid Angiosarcoma Occurring in Adrenal Cortical Adenoma. ( 25246132 )
2014
10
Adrenal cortical adenoma with the maximal diameter greater than 5 cm: can they be differentiated from adrenal cortical carcinoma by CT? ( 25419344 )
2014
11
Ectopic adrenal cortical adenoma in the gastric wall: case report. ( 23429246 )
2013
12
Adrenal cortical adenoma arising from an adrenohepatic union. ( 23686455 )
2013
13
Adrenal cortical adenoma: the fourth component of the Carney triad and an association with subclinical Cushing syndrome. ( 23681078 )
2013
14
Ultrastructural findings in adrenal cortical adenomas clinically mimicking pheochromocytoma: a comparison with other adrenal tumors and tissue preparation techniques. ( 23025647 )
2012
15
Transumbilical laparo-endoscopic single site surgery for adrenal cortical adenoma inducing primary aldosteronism: initial experience. ( 21943322 )
2011
16
Ectopic adrenal cortical adenoma in the spinal region: case report and review of the literature. ( 21046315 )
2010
17
Aldosterone-producing adrenal cortical adenoma with oncocytic change and cytoplasmic eosinophilic globular inclusions. ( 19462261 )
2009
18
Association of an oversized adrenal cortical adenoma with expression of pheochromocytoma-like neurosecretory features. ( 18979561 )
2008
19
Prenatal sonographic findings of congenital adrenal cortical adenoma. ( 18577675 )
2008
20
Myelolipoma within a non-functional adrenal cortical adenoma. ( 17609815 )
2007
21
Adrenal cortical adenoma in adrenohepatic fusion tissue: a mimic of malignant hepatic tumor at CT. ( 17312030 )
2007
22
Simultaneous occurrence of adrenal cortical adenoma and ganglioneuroma. ( 16879403 )
2006
23
Primary spinal intramedullary adrenal cortical adenoma associated with spinal dysraphism: case report. ( 17143207 )
2006
24
Unique association of non-functioning pheochromocytoma, ganglioneuroma, adrenal cortical adenoma, hepatic and vertebral hemangiomas in a patient with a new intronic variant in the VHL gene. ( 16483185 )
2005
25
Spinal adrenal cortical adenoma with oncocytic features: report of the first intramedullary case and review of the literature. ( 15306940 )
2004
26
Adrenal cortical adenoma with excess black pigment deposition, combined with myelolipoma and clinical Cushing's syndrome. ( 14765276 )
2004
27
Case of combined adrenal cortical adenoma and myelolipoma. ( 15363042 )
2004
28
F-18 fluorodeoxyglucose positron emission tomography-positive benign adrenal cortical adenoma: imaging features and pathologic correlation. ( 15069328 )
2004
29
A case of Cushing s syndrome in pregnancy secondary to an adrenal cortical adenoma. ( 12808338 )
2003
30
Utilization of molecular genetics in the differentiation between adrenal cortical adenomas and carcinomas. ( 9596277 )
1998
31
[Aberrant expression of the GIP (Gastric Inhibitory Polypeptide) receptor in an adrenal cortical adenoma responsible for a case of food-dependent Cushing's syndrome]. ( 10333644 )
1998
32
Bilateral adrenal cortical adenomas in primary hyperaldosteronism. ( 9763101 )
1998
33
Renal pathology in patients with primary hyperaldosteronism secondary to an adrenal cortical adenoma. ( 8804487 )
1996
34
Adrenal cortical adenoma and adrenal metastasis of renal cell carcinoma: immunohistochemical and DNA ploidy analysis. ( 7678935 )
1993
35
Pituitary prolactinoma, pancreatic glucagonomas, and aldosterone-producing adrenal cortical adenoma: a suggested variant of multiple endocrine neoplasia type I. ( 2824331 )
1987
36
Hyperaldosteronism with coexistence of adrenal cortical adenoma and pheochromocytoma. ( 288840 )
1979

Variations for Adrenal Cortical Adenoma

Expression for Adrenal Cortical Adenoma

Search GEO for disease gene expression data for Adrenal Cortical Adenoma.

Pathways for Adrenal Cortical Adenoma

Pathways related to Adrenal Cortical Adenoma according to GeneCards Suite gene sharing:

(show all 11)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.88 CYP11A1 CYP11B1 CYP17A1 CYP21A2 POMC SULT2A1
2
Show member pathways
12.56 CYP11A1 CYP11B1 CYP17A1 CYP21A2 MC2R NR5A1
3 11.8 GIPR MC2R POMC
4
Show member pathways
11.58 CYP11A1 MC2R POMC
5
Show member pathways
11.37 CYP11A1 CYP11B1 CYP17A1 CYP21A2
6 11.32 CYP11A1 CYP11B1 CYP21A2 POMC SULT2A1
7
Show member pathways
11.28 CYP11B1 CYP17A1 SULT2A1
8 11.18 CYP11A1 CYP17A1
9 11.09 POMC PRKAR1A
10
Show member pathways
10.97 CYP11A1 CYP11B1 CYP17A1 CYP21A2 POMC
11
Show member pathways
10.82 CYP11B1 CYP17A1 CYP21A2

GO Terms for Adrenal Cortical Adenoma

Biological processes related to Adrenal Cortical Adenoma according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 oxidation-reduction process GO:0055114 9.81 CYP11A1 CYP11B1 CYP17A1 CYP21A2
2 steroid biosynthetic process GO:0006694 9.56 CYP11A1 CYP11B1 CYP17A1 CYP21A2
3 steroid metabolic process GO:0008202 9.55 CYP11A1 CYP11B1 CYP17A1 CYP21A2 SULT2A1
4 generation of precursor metabolites and energy GO:0006091 9.52 GIPR POMC
5 cellular response to peptide hormone stimulus GO:0071375 9.49 CYP11A1 CYP11B1
6 C21-steroid hormone biosynthetic process GO:0006700 9.48 CYP11A1 CYP11B1
7 small molecule metabolic process GO:0044281 9.46 CYP11A1 CYP11B1
8 secondary metabolite biosynthetic process GO:0044550 9.43 CYP11A1 CYP11B1
9 dehydroaustinol biosynthetic process GO:1900563 9.4 CYP11A1 CYP11B1
10 cortisol metabolic process GO:0034650 9.37 CYP11A1 CYP11B1
11 austinol biosynthetic process GO:1900560 9.32 CYP11A1 CYP11B1
12 sterol metabolic process GO:0016125 9.26 CYP11A1 CYP11B1 CYP17A1 CYP21A2
13 glucocorticoid biosynthetic process GO:0006704 8.92 CYP11A1 CYP11B1 CYP17A1 CYP21A2

Molecular functions related to Adrenal Cortical Adenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 oxidoreductase activity GO:0016491 9.62 CYP11A1 CYP11B1 CYP17A1 CYP21A2
2 iron ion binding GO:0005506 9.46 CYP11A1 CYP11B1 CYP17A1 CYP21A2
3 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen GO:0016709 9.26 CYP11A1 CYP11B1
4 heme binding GO:0020037 9.26 CYP11A1 CYP11B1 CYP17A1 CYP21A2
5 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen GO:0016705 8.92 CYP11A1 CYP11B1 CYP17A1 CYP21A2

Sources for Adrenal Cortical Adenoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
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42 MedGen
44 MeSH
45 MESH via Orphanet
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54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
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74 UMLS via Orphanet
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