MCID: ADR041
MIFTS: 44

Adrenal Cortical Adenoma

Categories: Cancer diseases, Endocrine diseases

Aliases & Classifications for Adrenal Cortical Adenoma

MalaCards integrated aliases for Adrenal Cortical Adenoma:

Name: Adrenal Cortical Adenoma 12 15 72
Adrenocortical Adenoma 12 17
Adenoma Adrenocortical 55

Classifications:



External Ids:

Disease Ontology 12 DOID:0050891
UMLS 72 C0206667

Summaries for Adrenal Cortical Adenoma

Disease Ontology : 12 An adrenal adenoma that is a benign tumor of the adrenal cortex.

MalaCards based summary : Adrenal Cortical Adenoma, also known as adrenocortical adenoma, is related to adrenal adenoma and gangliocytoma. An important gene associated with Adrenal Cortical Adenoma is SYP (Synaptophysin), and among its related pathways/superpathways are Cytochrome P450 - arranged by substrate type and Aldosterone synthesis and secretion. The drugs Etomidate and Peripheral Nervous System Agents have been mentioned in the context of this disorder. Affiliated tissues include cortex, adrenal cortex and adrenal gland, and related phenotypes are Increased transferrin (TF) endocytosis and Reduced mammosphere formation

Wikipedia : 75 An adrenocortical adenoma is a benign tumor of the adrenal cortex. It can present with Cushing's... more...

Related Diseases for Adrenal Cortical Adenoma

Diseases related to Adrenal Cortical Adenoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 221)
# Related Disease Score Top Affiliating Genes
1 adrenal adenoma 31.1 POMC MC2R GIPR CYP21A2 CYP17A1 CYP11B1
2 gangliocytoma 30.9 SYP POMC
3 primary pigmented nodular adrenocortical disease 30.7 SYP PRKAR1A POMC
4 conn's syndrome 30.5 PRKAR1A POMC MC2R GIPR CYP21A2 CYP17A1
5 hyperandrogenism 30.2 POMC CYP21A2 CYP17A1
6 familial glucocorticoid deficiency 30.1 POMC MC2R
7 polycystic ovary syndrome 29.9 CYP21A2 CYP17A1 CYP11A1
8 leydig cell tumor 29.4 NR5A1 CYP21A2 CYP17A1 CYP11A1
9 testicular leydig cell tumor 29.3 POMC CYP21A2 CYP17A1 CYP11A1
10 pituitary-dependent cushing's disease 29.2 POMC CYP21A2
11 lipoid congenital adrenal hyperplasia 28.3 POMC NR5A1 MC2R CYP21A2 CYP17A1 CYP11B1
12 adrenal carcinoma 27.5 SYP POMC NR5A1 IGF2 CYP21A2 CYP17A1
13 adrenocortical carcinoma, hereditary 25.3 SYP SULT2A1 PRKAR1A POMC NR5A1 MC2R
14 adenoma 11.0
15 tuberculum sellae meningioma 10.5 SYP POMC
16 spermatocele 10.5 SYP NR5A1
17 sella turcica neoplasm 10.5 SYP POMC
18 pancreatic endocrine carcinoma 10.5 SYP POMC
19 pheochromocytoma 10.5
20 adrenal gland pheochromocytoma 10.5
21 olfactory nerve neoplasm 10.5 SYP POMC
22 myxosarcoma 10.5 SYP PRKAR1A
23 ovarian small cell carcinoma 10.5 SYP INHA
24 abducens nerve disease 10.4 SYP POMC
25 cervix small cell carcinoma 10.4 SYP POMC
26 cerebral neuroblastoma 10.3 SYP IGF2
27 glucocorticoid deficiency 1 10.3 POMC MC2R
28 precocious puberty 10.3
29 hyperaldosteronism, familial, type i 10.3 POMC CYP11B1
30 endocrine organ benign neoplasm 10.3 SYP POMC CYP11B1
31 cranial nerve malignant neoplasm 10.3 SYP POMC
32 classic congenital adrenal hyperplasia due to 21-hydroxylase deficiency 10.3 POMC CYP21A2
33 granulosa cell tumor of the ovary 10.3 SYP INHA
34 sertoli cell tumor 10.3 SYP PRKAR1A INHA
35 papilloma of choroid plexus 10.3 SYP IGF2
36 achalasia-addisonianism-alacrima syndrome 10.2 POMC MC2R
37 transsexualism 10.2 CYP21A2 CYP17A1
38 adrenal cortical carcinoma 10.2
39 fasting hypoglycemia 10.2 POMC IGF2
40 ectopic cushing syndrome 10.2 SYP POMC
41 renal cell carcinoma, nonpapillary 10.2
42 hypertension, essential 10.2
43 neurofibromatosis, type ii 10.2
44 infant gynecomastia 10.2
45 gynecomastia 10.2
46 hypospadias 10.2 NR5A1 CYP17A1 CYP11A1
47 oncocytoma 10.1
48 familial adenomatous polyposis 10.1
49 thyroiditis 10.1
50 thyroid carcinoma 10.1

Graphical network of the top 20 diseases related to Adrenal Cortical Adenoma:



Diseases related to Adrenal Cortical Adenoma

Symptoms & Phenotypes for Adrenal Cortical Adenoma

GenomeRNAi Phenotypes related to Adrenal Cortical Adenoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased transferrin (TF) endocytosis GR00363-A 9.61 CYP11A1 CYP11B1 CYP21A2 GIPR INHA MC2R
2 Reduced mammosphere formation GR00396-S 9.1 CYP11B1 CYP21A2 GIPR IGF2 MC2R POMC

MGI Mouse Phenotypes related to Adrenal Cortical Adenoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.07 CYP11A1 CYP11B1 CYP17A1 IGF2 MC2R NR2F1
2 cardiovascular system MP:0005385 9.92 CYP11A1 CYP11B1 IGF2 INHA MC2R NR5A1
3 endocrine/exocrine gland MP:0005379 9.91 CYP11A1 CYP11B1 GIPR IGF2 INHA MC2R
4 growth/size/body region MP:0005378 9.81 CYP11A1 CYP11B1 CYP17A1 IGF2 INHA MC2R
5 homeostasis/metabolism MP:0005376 9.65 CYP11A1 CYP11B1 CYP17A1 GIPR IGF2 INHA
6 mortality/aging MP:0010768 9.32 CYP11A1 CYP11B1 CYP17A1 IGF2 INHA MC2R

Drugs & Therapeutics for Adrenal Cortical Adenoma

Drugs for Adrenal Cortical Adenoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 76)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Etomidate Approved Phase 3 33125-97-2 36339 667484
2 Peripheral Nervous System Agents Phase 3
3 Autonomic Agents Phase 3
4 Central Nervous System Depressants Phase 3
5 Hypnotics and Sedatives Phase 3
6 Anesthetics Phase 3
7 Anesthetics, General Phase 3
8 Anesthetics, Intravenous Phase 3
9 Neurotransmitter Agents Phase 3
10 Sympathomimetics Phase 3
11 Adrenergic Agonists Phase 3
12 Adrenergic alpha-Agonists Phase 3
13 Adrenergic beta-Agonists Phase 3
14 Respiratory System Agents Phase 3
15 Mydriatics Phase 3
16 Adrenergic Agents Phase 3
17 Vasoconstrictor Agents Phase 3
18 Anti-Asthmatic Agents Phase 3
19 Bronchodilator Agents Phase 3
20 Fluorodeoxyglucose F18 Phase 3
21 Adrenocorticotropic Hormone Phase 2
22 Antiemetics Phase 2
23 Gastrointestinal Agents Phase 2
24 HIV Protease Inhibitors Phase 2
25 glucocorticoids Phase 2
26
protease inhibitors Phase 2
27 Antineoplastic Agents, Hormonal Phase 2
28
Dopamine Approved 51-61-6, 62-31-7 681
29
Ethanol Approved 64-17-5 702
30
Eplerenone Approved 107724-20-9 150310 443872
31
Spironolactone Approved 1952-01-7, 52-01-7 5833
32
Amiloride Approved 2016-88-8, 2609-46-3 16231
33
Diltiazem Approved, Investigational 42399-41-7 39186
34
Angiotensin II Approved, Investigational 11128-99-7, 68521-88-0, 4474-91-3 172198
35
Amlodipine Approved 88150-42-9 2162
36
Bisoprolol Approved 66722-44-9 2405
37
Indapamide Approved 26807-65-8 3702
38
Prazosin Approved 19216-56-9 4893
39
Racepinephrine Approved 329-65-7 838
40
Epinephrine Approved, Vet_approved 51-43-4 5816
41
Dexamethasone Approved, Investigational, Vet_approved 50-02-2 5743
42
Dexamethasone acetate Approved, Investigational, Vet_approved 1177-87-3
43
Hydrocortisone Approved, Vet_approved 50-23-7 5754
44
Hydrocortisone acetate Approved, Vet_approved 50-03-3
45
Clarithromycin Approved 81103-11-9 84029
46 Cardiotonic Agents
47 Dopamine Agents
48 Protective Agents
49 insulin
50 Insulin, Globin Zinc

Interventional clinical trials:

(show all 23)
# Name Status NCT ID Phase Drugs
1 Combined 18F-Fluorodeoxyglucose (FDG) Positron Emission Tomography (PET) and 123I-Iodometomidate (123I-IMTO) Imaging for Adrenal Neoplasia Recruiting NCT02010957 Phase 3
2 A Phase II, Open-label, Dose Titration, Multi-center Study to Assess the Safety/Tolerability and Efficacy of Osilodrostat in Patients With All Types of Endogenous Cushing's Syndrome Except Cushing's Disease Completed NCT02468193 Phase 2 Osilodrostat
3 A Multicenter Medical Safety Follow-up Study for Patients With Partial Onset Seizures Who Received More Than 28 Days of Total Exposure to BGG492 in Studies CBGG492A2207 and/or CBGG492A2212 Completed NCT02150213 Phase 2 BGG492
4 Laparoscopic Adrenalectomy Versus Radiofrequency Ablation for Aldosterone-producing Adenoma: a Prospective Randomized Controlled Trial Unknown status NCT02030587
5 Expression of D2-Like Dopamine Receptor of Human Aldosterone-Producing Adenoma and Its Role in Regulation of Aldosterone Secretion and Cell Proliferation Unknown status NCT00173446
6 Evaluation of the Diagnostic Utility of Serum Dexamethasone Measurements in the Overnight 1mg Dexamethasone Suppression Test in Patients Investigated for Cushing's Syndrome and Incidentalomas Unknown status NCT01504555
7 Radiofrequency Ablation for Aldosterone-producting Adenoma in Patients With Primary Aldosteronism: Evaluation of the Blood Pressure Control and of Its Safety. Completed NCT02756754
8 Is There Anything New in the Field of Large Adrenal Tumors ? Completed NCT03830593
9 Complex Cystic Benign Adrenal Incidentalomas Mimicking Non-adenomatous Masses; Rare Pathologies: Clinical Features and Outcomes. Case Series With Short Review of Literature. Completed NCT03739918
10 Cardiovascular Risk in Patients With Non-Functional Adrenal Incidentaloma: Myth or Reality? Completed NCT00768365
11 Primary Aldosteronism and Surgically Curable Forms in Hypertension Patients Using 11C-Metomidate Recruiting NCT03990701 Early Phase 1
12 Glucose Metabolism in Subjects With Aldosterone-Producing Adenomas Recruiting NCT02362308 mineralocorticoid receptor antagonist
13 Efficacy and Safety of Renal Sympathetic Denervation From The Adventitia on Hypertension in Patients With Primary Aldosteronism Recruiting NCT02642445
14 Prospective Study Assessing Blood Pressure, Cardiovascular, Endothelial and Other Outcomes poSt-surgical and Medical Treatment in Patients With Primary Aldosteronism Recruiting NCT03174847 Mineralocorticoid Receptor Antagonists
15 Effect of Chronic Catecholamine Overproduction on Brown Adipose Tissue Recruiting NCT01949714
16 Long-term Effects of Adrenalectomy on Metabolic Syndrome, Glucose Metabolism, Lipid Metabolism, and Bone Metabolism in Subclinical Cushing's Syndrome of Adrenal Incidentaloma Recruiting NCT01382420
17 Feasibility Study of RadioFrequency Endoscopic ABlation, With ULtrasound Guidance, as a Non-surgical, Adrenal Sparing Treatment for Aldosterone-producing Adenomas Recruiting NCT03405025
18 Structured Evaluation of adRENal Tumors Discovered Incidentally - Prospectively Investigating the Testing Yield Recruiting NCT02324647
19 Surgery of Subclinical Cortisol Secreting Adrenal Incidentalomas Recruiting NCT02364089 Standardized medical treatment of hypertension by SAHR
20 Morbidity and Mortality in Patients With Adrenal Incidentalomas With and Without Autonomous Cortisol Secretion Active, not recruiting NCT03919734
21 Macrolides for KCNJ5 - Mutated Aldosterone-Producing Adenoma (MAPA): A Study Of Personalized Diagnosis of Primary Aldosteronism With Implications For Treatment Not yet recruiting NCT03414918 Clarithromycin
22 The Intra-Procedural Cortisol Assay During Adrenal Vein Sampling: Rationale andDesign of A Randomized Study (I-PADUA) Not yet recruiting NCT03449797
23 A Prospective Cohort Study for Patients With Adrenal Diseases Not yet recruiting NCT03474237

Search NIH Clinical Center for Adrenal Cortical Adenoma

Genetic Tests for Adrenal Cortical Adenoma

Anatomical Context for Adrenal Cortical Adenoma

MalaCards organs/tissues related to Adrenal Cortical Adenoma:

41
Cortex, Adrenal Cortex, Adrenal Gland, Pituitary, Testes, Thyroid, Endothelial

Publications for Adrenal Cortical Adenoma

Articles related to Adrenal Cortical Adenoma:

(show top 50) (show all 921)
# Title Authors PMID Year
1
Biallelic APC inactivation was responsible for functional adrenocortical adenoma in familial adenomatous polyposis with novel germline mutation of the APC gene: report of a case. 9 38
19684041 2009
2
Detection of somatic beta-catenin mutations in primary pigmented nodular adrenocortical disease (PPNAD). 9 38
18419788 2008
3
The role of immunohistochemistry in histopathological diagnostics of clinically "silent" incidentally detected adrenal masses. 9 38
18393131 2008
4
Unique association of non-functioning pheochromocytoma, ganglioneuroma, adrenal cortical adenoma, hepatic and vertebral hemangiomas in a patient with a new intronic variant in the VHL gene. 9 38
16483185 2005
5
Significance of inhibin in reproductive pathophysiology and current clinical applications. 9 38
15970011 2005
6
Myxoid adrenocortical adenoma with a pseudoglandular pattern. 9 38
15235911 2004
7
Analysis of somatic APC mutations in rare extracolonic tumors of patients with familial adenomatous polyposis coli. 9 38
15287021 2004
8
Primary hyperparathyroidism associatiated with aldosterone-producing adrenocortical adenoma and breast cancer: relation to MEN1 gene. 9 38
15168774 2004
9
[The expression of A103 and inhibin alpha in adrenocortical adenoma by high-throughput tissue microarray techniques]. 9 38
12910679 2003
10
Massive adrenocortical adenoma following long-term treatment of 21-hydroxylase deficiency. 9 38
11832743 2002
11
Immunoexpression of inhibin alpha-subunit in adrenal neoplasms. 9 38
11556749 2001
12
Expression of adrenocorticotropin receptor gene in adrenocortical adenomas from patients with Cushing syndrome: possible contribution for the autonomous production of cortisol. 9 38
11420487 2001
13
Food-dependent androgen and cortisol secretion by a gastric inhibitory polypeptide-receptor expressive adrenocortical adenoma leading to hirsutism and subclinical Cushing's syndrome: in vivo and in vitro studies. 9 38
11158012 2001
14
Virilizing adrenocortical adenoma: in vitro steroidogenesis, immunohistochemical studies of steroidogenic enzymes, and gene expression of corticotropin receptor. 9 38
10216530 1999
15
Gene expression and roles of angiotensin II type 1 and type 2 receptors in human adrenals. 9 38
9761377 1998
16
[Aberrant expression of the GIP (Gastric Inhibitory Polypeptide) receptor in an adrenal cortical adenoma responsible for a case of food-dependent Cushing's syndrome]. 9 38
10333644 1998
17
Aldosterone-producing adrenocortical adenoma complicated by chronic renal failure. Case report and review of the literature. 9 38
9845833 1998
18
Evaluation of plasma aldosterone to plasma renin activity ratio in patients with primary aldosteronism. 9 38
9249232 1997
19
Oestrogen producing adrenocortical adenoma: clinical, biochemical and immunohistochemical studies. 9 38
8977764 1996
20
Immunolocalization of dehydroepiandrosterone sulfotransferase in normal and pathologic human adrenal gland. 9 38
8751327 1995
21
Expression of a high molecular weight form of insulin-like growth factor II in a Beckwith-Wiedemann syndrome associated adrenocortical adenoma. 9 38
7621447 1995
22
In-vitro evidence for the regulation of 17,20-lyase activity by cytochrome b5 in adrenocortical adenomas from patients with Cushing's syndrome. 9 38
8137519 1994
23
Mechanism of abnormal production of adrenal androgens in patients with adrenocortical adenomas and carcinomas. 9 38
8288710 1994
24
Disordered expression of adrenal steroidogenic P450 mRNAs in incidentally discovered nonfunctioning adrenal adenoma. 9 38
1535042 1992
25
Decreased levels of steroid 21-hydroxylase [P450(c21)] and its mRNA in an adrenocortical adenoma associated with 21-hydroxylase deficiency. 9 38
2101789 1990
26
Endocrine activity of the "silent" adrenocortical adenoma is uncovered by response to corticotropin-releasing hormone. 9 38
2165544 1990
27
The Utrecht Score: A novel histopathological scoring system to assess the prognosis of dogs with cortisol-secreting adrenocortical tumours. 38
30860644 2019
28
IGF2 role in adrenocortical carcinoma biology. 38
31378849 2019
29
Presentation, Treatment, Histology, and Outcomes in Adrenal Medullary Hyperplasia Compared With Pheochromocytoma. 38
31384714 2019
30
Validity of discharge ICD-10 codes in detecting the etiologies of endogenous Cushing's syndrome. 38
31340196 2019
31
Laparoscopic Adrenalectomy: Two Years Experience at Bangabandhu Sheikh Mujib Medical University. 38
31391438 2019
32
18-Oxocortisol Synthesis in Aldosterone-Producing Adrenocortical Adenoma and Significance of KCNJ5 Mutation Status. 38
31006333 2019
33
Changes in total and acylated ghrelin in patients with adrenocortical carcinoma during mitotane treatment. 38
31169262 2019
34
Adrenal Myelolipoma with Adrenocortical Adenoma Presenting with Hypertension Only. 38
31142427 2019
35
Intrahepatic adrenocortical adenoma arising from adrenohepatic fusion mimicking hepatic malignancy: Two case reports. 38
31169702 2019
36
Adrenal Cortical Adenoma in the Spinal Canal: A Case Report and Review of the Literature. 38
31127594 2019
37
Tubulopapillary adrenocortical adenoma in a patient with familial adenomatous polyposis: a morphologic, ultrastructural, and molecular study. 38
30172912 2019
38
Comparison of plasma and urinary microRNA-483-5p for the diagnosis of adrenocortical malignancy. 38
30940435 2019
39
Expression profiles analysis identifies the values of carcinogenesis and the prognostic prediction of three genes in adrenocortical carcinoma. 38
30816525 2019
40
A successful pregnancy in a patient with secondary hypertension caused by adrenal adenoma: a case report. 38
30943935 2019
41
Double trouble: two cases of dual adrenal pathologies in one adrenal mass. 38
30909165 2019
42
Adrenal adenoma in von Hippel-Lindau syndrome: A case report with review of literature. 38
30900640 2019
43
CT Characteristics of Pheochromocytoma: Relevance for the Evaluation of Adrenal Incidentaloma. 38
30383267 2019
44
Exacerbation of Cushing's syndrome during pregnancy: stimulation of a cortisol-secreting adrenocortical adenoma by ACTH originating from the foeto-placental unit. 38
30738017 2019
45
Diagnostic Role of Prostate-Specific Membrane Antigen in Adrenocortical Carcinoma. 38
31040822 2019
46
Demographic Characteristics, Etiology, and Comorbidities of Patients with Cushing's Syndrome: A 10-Year Retrospective Study at a Large General Hospital in China. 38
30915114 2019
47
A rare case of pure testosterone-secreting adrenal adenoma in a postmenopausal elderly woman. 38
30674304 2019
48
Incidental retroperitoneal oncocytoma (Ectopic oncocytic adrenocortical adenoma): Case report and review of the literature. 38
30706878 2019
49
[A Case of Laparoscopic Low Anterior Resection and Adrenalectomy for Rectal Cancer and Adrenal Tumor]. 38
30692479 2018
50
An ectopic adrenocortical adenoma in renal hilum presenting with Cushing's syndrome: A case report and literature review. 38
30557981 2018

Variations for Adrenal Cortical Adenoma

Expression for Adrenal Cortical Adenoma

Search GEO for disease gene expression data for Adrenal Cortical Adenoma.

Pathways for Adrenal Cortical Adenoma

Pathways related to Adrenal Cortical Adenoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.88 SULT2A1 POMC CYP21A2 CYP17A1 CYP11B1 CYP11A1
2
Show member pathways
12.47 POMC NR5A1 MC2R CYP21A2 CYP17A1 CYP11B1
3 11.8 POMC MC2R GIPR
4
Show member pathways
11.58 POMC MC2R CYP11A1
5
Show member pathways
11.38 CYP21A2 CYP17A1 CYP11B1 CYP11A1
6 11.32 SULT2A1 POMC CYP21A2 CYP11B1 CYP11A1
7
Show member pathways
11.28 SULT2A1 CYP17A1 CYP11B1
8 10.98 NR5A1 INHA
9
Show member pathways
10.97 POMC CYP21A2 CYP17A1 CYP11B1 CYP11A1
10
Show member pathways
10.82 CYP21A2 CYP17A1 CYP11B1

GO Terms for Adrenal Cortical Adenoma

Biological processes related to Adrenal Cortical Adenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 steroid biosynthetic process GO:0006694 9.56 CYP21A2 CYP17A1 CYP11B1 CYP11A1
2 steroid metabolic process GO:0008202 9.55 SULT2A1 CYP21A2 CYP17A1 CYP11B1 CYP11A1
3 cellular response to peptide hormone stimulus GO:0071375 9.37 CYP11B1 CYP11A1
4 C21-steroid hormone biosynthetic process GO:0006700 9.32 CYP11B1 CYP11A1
5 sterol metabolic process GO:0016125 9.13 CYP21A2 CYP11B1 CYP11A1
6 glucocorticoid biosynthetic process GO:0006704 8.92 CYP21A2 CYP17A1 CYP11B1 CYP11A1

Molecular functions related to Adrenal Cortical Adenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 iron ion binding GO:0005506 9.46 CYP21A2 CYP17A1 CYP11B1 CYP11A1
2 hormone activity GO:0005179 9.43 POMC INHA IGF2
3 heme binding GO:0020037 9.26 CYP21A2 CYP17A1 CYP11B1 CYP11A1
4 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen GO:0016705 8.92 CYP21A2 CYP17A1 CYP11B1 CYP11A1

Sources for Adrenal Cortical Adenoma

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