Adrenal Cortical Adenoma disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: ADR041 MIFTS: 49	Adrenal Cortical Adenoma Categories: Cancer diseases, Endocrine diseases	Data Licensing For inquiries, contact: [email protected]
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Aliases & Classifications for Adrenal Cortical Adenoma

MalaCards integrated aliases for Adrenal Cortical Adenoma:

Name: Adrenal Cortical Adenoma ¹¹ ¹⁴ ⁷¹

Adrenocortical Adenoma ¹¹ ⁵ ¹⁶ ⁷⁵

Adenoma Adrenocortical ⁵³

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Endocrine diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹¹ DOID:0050891

EFO ¹⁶ EFO_0003104

UMLS ⁷¹ C0206667

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Summaries for Adrenal Cortical Adenoma

Disease Ontology: ¹¹ An adrenal adenoma that is a benign tumor of the adrenal cortex.

MalaCards based summary: Adrenal Cortical Adenoma, also known as adrenocortical adenoma, is related to adrenal adenoma and adenoma. An important gene associated with Adrenal Cortical Adenoma is MEN1 (Menin 1), and among its related pathways/superpathways are Metapathway biotransformation Phase I and II and Diseases of glycosylation. The drugs Dexamethasone acetate and Dexamethasone have been mentioned in the context of this disorder. Affiliated tissues include adrenal cortex, cortex and pituitary, and related phenotypes are Reduced mammosphere formation and homeostasis/metabolism

Wikipedia: ⁷⁵ Adrenocortical adenoma is commonly described as a benign neoplasm emerging from the cells that comprise... more...

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Related Diseases for Adrenal Cortical Adenoma

Diseases related to Adrenal Cortical Adenoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 378)

#	Related Disease	Score	Top Affiliating Genes
1	adrenal adenoma	31.1	REN PRKAR1A POMC MIR483 MEN1 MC2R
2	adenoma	31.0	SYP REN PRKAR1A POMC MEN1 MC2R
3	premature ovarian failure 7	30.7	POMC NR5A1
4	acne	30.5	POMC CYP21A2 CYP17A1
5	pheochromocytoma	30.5	SYP REN POMC MEN1 IGF2 CHGA
6	adrenogenital syndrome	30.4	SYP INHA CYP21A2
7	neurilemmoma	30.4	SYP PRKAR1A MLANA
8	hypokalemia	30.3	REN POMC CYP17A1 CYP11B1
9	pituitary-dependent cushing's disease	30.3	POMC MC2R
10	amenorrhea	30.3	POMC NR5A1 CYP17A1
11	hemangioma	30.3	SYP MEN1 IGF2 CHGA
12	liddle syndrome 1	30.3	REN POMC CYP11B1
13	multiple endocrine neoplasia	30.2	SYP PRKAR1A POMC MEN1 CHGA
14	hyperandrogenism	30.2	POMC IGF2 CYP21A2 CYP17A1 CYP11A1
15	functioning pituitary adenoma	30.2	PRKAR1A POMC MEN1
16	beckwith-wiedemann syndrome	30.2	PRKAR1A MIR483 MEN1 IGF2
17	primary hyperparathyroidism	30.2	PRKAR1A MEN1 CHGA
18	acth-independent macronodular adrenal hyperplasia	30.2	PRKAR1A POMC MEN1 MC2R GIPR CYP11B1
19	hyperparathyroidism	30.2	PRKAR1A MEN1 CHGA
20	carcinoid syndrome	30.2	SYP CHGA
21	parathyroid adenoma	30.2	SYP PRKAR1A MEN1 CHGA
22	intrauterine growth retardation, metaphyseal dysplasia, adrenal hypoplasia congenita, and genital anomalies	30.2	NR5A1 MC2R CYP11A1
23	appendix adenocarcinoma	30.2	SYP CHGA
24	carcinoid tumors, intestinal	30.2	SYP MEN1 CHGA
25	acute adrenal insufficiency	30.1	POMC CYP21A2 CYP11A1
26	granular cell tumor	30.1	SYP MLANA INHA
27	prolactinoma	30.1	PRKAR1A POMC MEN1 CHGA
28	meningioma, familial	30.1	SYP PRKAR1A POMC MLANA MEN1 IGF2
29	polycystic ovary syndrome	30.0	SULT2A1 POMC IGF2 CYP21A2 CYP17A1 CYP11A1
30	pituitary adenoma	29.9	PRKAR1A POMC MEN1 CHGA
31	multiple endocrine neoplasia, type i	29.9	SYP PRKAR1A POMC MIR483 MEN1 CHGA
32	primary pigmented nodular adrenocortical disease	29.9	PRKAR1A POMC MIR483 MEN1 MC2R CYP17A1
33	hypogonadotropic hypogonadism	29.8	POMC NR5A1 INHA CYP21A2 CYP17A1
34	acromegaly	29.8	POMC MEN1 IGF2
35	hypertension, essential	29.7	REN POMC MIR483 MEN1 CYP17A1 CYP11B1
36	pseudohermaphroditism	29.7	POMC NR5A1 CYP21A2 CYP17A1 CYP11B1 CYP11A1
37	leydig cell tumor	29.7	SYP NR5A1 INHA CYP21A2 CYP17A1 CYP11A1
38	gastrointestinal stromal tumor	29.7	SYP MLANA MEN1 IGF2 CHGA
39	paraganglioma	29.7	SYP REN POMC MLANA MEN1 IGF2
40	conn's syndrome	29.5	SYP SULT2A1 REN PRKAR1A POMC NR5A1
41	wilms tumor 1	29.4	SYP REN NR5A1 MLANA MIR483 IGF2
42	familial glucocorticoid deficiency	29.3	REN POMC NR5A1 MC2R CYP21A2 CYP17A1
43	type 2 diabetes mellitus	29.1	REN POMC MIR483 IGF2 GIPR CYP21A2
44	carney complex variant	29.1	PRKAR1A POMC NR5A1 MLANA MIR483 MEN1
45	lipoid congenital adrenal hyperplasia	28.9	SULT2A1 REN POMC NR5A1 MC2R CYP21A2
46	adrenal carcinoma	28.5	SYP REN PRKAR1A POMC NR5A1 MLANA
47	adrenal cortical carcinoma	28.0	SYP SULT2A1 REN PRKAR1A POMC NR5A1
48	adrenal gland disease	27.9	SYP REN PRKAR1A POMC NR5A1 MLANA
49	acth-independent cushing syndrome	11.2
50	breast ductal adenoma	10.4	PRKAR1A GIPR

Graphical network of the top 20 diseases related to Adrenal Cortical Adenoma:

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Symptoms & Phenotypes for Adrenal Cortical Adenoma

GenomeRNAi Phenotypes related to Adrenal Cortical Adenoma according to GeneCards Suite gene sharing:

²⁵

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Reduced mammosphere formation	GR00396-S	9.23	CHGA CYP11B1 CYP21A2 GIPR IGF2 MC2R

MGI Mouse Phenotypes related to Adrenal Cortical Adenoma:

⁴⁵

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	homeostasis/metabolism	MP:0005376	10.25	CHGA CYB5A CYP11A1 CYP11B1 CYP17A1 GIPR
2	nervous system	MP:0003631	10.22	CHGA CYP11A1 CYP11B1 IGF2 MC2R MEN1
3	growth/size/body region	MP:0005378	10.21	CHGA CYP11A1 CYP11B1 CYP17A1 CYP21A2 IGF2
4	muscle	MP:0005369	10.06	CHGA CYP11A1 CYP11B1 IGF2 MEN1 NR2F1
5	endocrine/exocrine gland	MP:0005379	10.06	CHGA CYP11A1 CYP11B1 GIPR IGF2 INHA
6	liver/biliary system	MP:0005370	10.03	CYB5A CYP11A1 CYP11B1 IGF2 INHA MEN1
7	cardiovascular system	MP:0005385	10.03	CHGA CYP11A1 CYP11B1 CYP17A1 IGF2 INHA
8	behavior/neurological	MP:0005386	9.97	CYP11A1 CYP11B1 CYP17A1 CYP21A2 IGF2 MC2R
9	reproductive system	MP:0005389	9.65	CHGA CYP11A1 CYP11B1 CYP17A1 IGF2 INHA
10	mortality/aging	MP:0010768	9.47	CHGA CYP11A1 CYP11B1 CYP17A1 CYP21A2 IGF2

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Drugs & Therapeutics for Adrenal Cortical Adenoma

Drugs for Adrenal Cortical Adenoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 51)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Dexamethasone acetate

Approved, Investigational, Vet_approved

Phase 4

1177-87-3

3680

Dexamethasone

Approved, Investigational, Vet_approved

Phase 4

50-02-2

3003 5743

Hydrocortisone succinate

Approved

Phase 4

2203-97-6

3643

Hydrocortisone acetate

Approved, Vet_approved

Phase 4

50-03-3

Hydrocortisone

Approved, Vet_approved

Phase 4

50-23-7

3640 5754

Racepinephrine

Approved, Vet_approved

Phase 4

51-43-4, 329-65-7

838 5816

Nutmeg

Approved

Phase 4

Hydrocortisone 17-butyrate 21-propionate

Phase 4

Epinephryl borate

Phase 4

Mace

Phase 4

Melanocyte-Stimulating Hormones

Phase 3

Adrenocorticotropic Hormone

Phase 3

beta-Endorphin

Phase 3

Dopamine

Approved

62-31-7, 51-61-6

681

Ethanol

Approved

64-17-5

702

Zinc cation

Approved, Experimental, Investigational

7440-66-6, 23713-49-7

32051

Amlodipine

Approved

88150-42-9

2162

Diltiazem

Approved, Investigational

42399-41-7

39186

Prazosin

Approved

19216-56-9

4893

Angiotensin II

Approved, Investigational

68521-88-0, 11128-99-7, 4474-91-3

172198

Spironolactone

Approved

1952-01-7, 52-01-7

5833

Bisoprolol

Approved

66722-44-9

2405

Indapamide

Approved

26807-65-8

3702

Prasterone

Approved, Investigational, Nutraceutical

53-43-0

5881

Insulin, Globin Zinc

Insulin

Hypoglycemic Agents

DHEA (Dehydroepiandrosterone)

Antineoplastic Agents, Hormonal

Antiemetics

glucocorticoids

Anti-Inflammatory Agents

Gastrointestinal Agents

Bronchodilator Agents

Neurotransmitter Agents

Adrenergic beta-Agonists

Adrenergic alpha-Agonists

Anti-Asthmatic Agents

Adrenergic Agonists

Adrenergic Agents

Vasoconstrictor Agents

Respiratory System Agents

Mydriatics

Sympathomimetics

Antihypertensive Agents

Angiotensinogen

16133225

Angiotensin-Converting Enzyme Inhibitors

Angiotensin Receptor Antagonists

Giapreza

Hormones

Interventional clinical trials:

(show all 30)

#	Name	Status	NCT ID	Phase	Drugs
1	An Oral GnRH Antagonist to Treat Mild Autonomous Cortisol Excess (MACE) Due to Adrenal Adenomas in Postmenopausal Women	Recruiting	NCT05038878	Phase 4	Elagolix
2	Glucocorticoid Receptor Antagonism in the Treatment of Hypercortisolism in Patients With Cortisol-Secreting Adrenal Adenomas or Hyperplasia: A Phase 3, Randomized, Double-Blind, Placebo-Controlled Study of the Efficacy and Safety of Relacorilant	Recruiting	NCT04308590	Phase 3	relacorilant
3	A Multicenter Medical Safety Follow-up Study for Patients With Partial Onset Seizures Who Received More Than 28 Days of Total Exposure to BGG492 in Studies CBGG492A2207 and/or CBGG492A2212	Completed	NCT02150213	Phase 2	BGG492
4	A Phase II, Open-label, Dose Titration, Multi-center Study to Assess the Safety/Tolerability and Efficacy of Osilodrostat in Patients With All Types of Endogenous Cushing's Syndrome Except Cushing's Disease	Completed	NCT02468193	Phase 2	Osilodrostat
5	Laparoscopic Adrenalectomy Versus Radiofrequency Ablation for Aldosterone-producing Adenoma: a Prospective Randomized Controlled Trial	Unknown status	NCT02030587
6	Natural History of Benign Nonfunctioning Adrenal Tumors: 10 Year Follow-up Results	Unknown status	NCT04616703
7	Expression of D2-Like Dopamine Receptor of Human Aldosterone-Producing Adenoma and Its Role in Regulation of Aldosterone Secretion and Cell Proliferation	Unknown status	NCT00173446
8	Feasibility Study of RadioFrequency Endoscopic ABlation, With ULtrasound Guidance, as a Non-surgical, Adrenal Sparing Treatment for Aldosterone-producing Adenomas	Unknown status	NCT03405025
9	Evaluation of the Diagnostic Utility of Serum Dexamethasone Measurements in the Overnight 1mg Dexamethasone Suppression Test in Patients Investigated for Cushing's Syndrome and Incidentalomas	Unknown status	NCT01504555
10	Complex Cystic Benign Adrenal Incidentalomas Mimicking Non-adenomatous Masses; Rare Pathologies: Clinical Features and Outcomes. Case Series With Short Review of Literature.	Completed	NCT03739918
11	Radiofrequency Ablation for Aldosterone-producting Adenoma in Patients With Primary Aldosteronism: Evaluation of the Blood Pressure Control and of Its Safety.	Completed	NCT02756754
12	Effect of Chronic Catecholamine Overproduction on Brown Adipose Tissue	Completed	NCT01949714
13	Characteristics Predicting Clinically Relevant Reduction of Hypertension Following Adrenalectomy for Primary Aldosteronism: a Multicenter Analysis	Completed	NCT04761354
14	Morbidity and Mortality in Patients With Adrenal Incidentalomas With and Without Autonomous Cortisol Secretion	Completed	NCT03919734
15	Prevention of Conversion in Posterior Retroperitoneal Adrenalectomy by Measuring Preoperative Anatomical Conditions on Cross-sectional Imaging (CT or MRI)	Completed	NCT04071561
16	Cardiovascular Risk in Patients With Non-Functional Adrenal Incidentaloma: Myth or Reality?	Completed	NCT00768365
17	Is There Anything New in the Field of Large Adrenal Tumors ?	Completed	NCT03830593
18	The Prevalence and Characteristics of Adrenal Incidentaloma: A Prospective Study	Completed	NCT04682938
19	Comparison of Imaging Quality Between Spectral Photon Counting Computed Tomography (SPCCT) and Dual Energy Computed Tomography (DECT)	Recruiting	NCT04328181
20	Impact of Adrenal IncidenTalomas and Possible Autonomous Cortisol Secretion on Cardiovascular and Metabolic Alterations (ITACA Study)	Recruiting	NCT04127552
21	The Cross-sectional Study and Longitudinal Study of the Diagnostic Efficiency of Serum Dehydroepiandrosterone Sulfate in Subclinical Hypercortisolism	Recruiting	NCT04833192
22	If Adrenal Incidentalomas Have the Influences to Occur and Progress in Patients With Stroke	Recruiting	NCT05237817
23	Structured Evaluation of adRENal Tumors Discovered Incidentally - Prospectively Investigating the Testing Yield	Recruiting	NCT02324647
24	China Adrenal Disease Registry Study	Recruiting	NCT04890444
25	Long-term Effects of Adrenalectomy on Metabolic Syndrome, Glucose Metabolism, Lipid Metabolism, and Bone Metabolism in Subclinical Cushing's Syndrome of Adrenal Incidentaloma	Recruiting	NCT01382420
26	A Single Center, Prospective, Observational Study to Explore and Evaluate the Differences of Cognitive Function and Brain Function Between Non-functioning Adrenal Adenomas and Autonomous Cortisol Secretion Patients, and the Different Treatments Methods on Cognitive Function and Brain Function in Patients With Autonomous Cortisol Secretion	Recruiting	NCT05357456
27	Surgery of Subclinical Cortisol Secreting Adrenal Incidentalomas	Active, not recruiting	NCT02364089		Standardized medical treatment of hypertension by SAHR
28	Effect of Surgical or Conservative Approach in Patients With Adrenal Incidentalomas on Cardiovascular, Metabolic, Neuropsychological and Bone Manifestations: Respective Roles of Cortisol Secretion and Glucocorticoid Sensitivity	Active, not recruiting	NCT04860180
29	Clinical Outcome of Autonomous Cortisol Secretion in Adrenal Incidentalomas - Substudy of the ENSAT (European Network for the Study of Adrenal Tumor) Registry	Active, not recruiting	NCT04917757
30	A Prospective Cohort Study for Patients With Adrenal Diseases	Enrolling by invitation	NCT03474237

Search NIH Clinical Center for Adrenal Cortical Adenoma

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Genetic Tests for Adrenal Cortical Adenoma

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Anatomical Context for Adrenal Cortical Adenoma

Organs/tissues related to Adrenal Cortical Adenoma:

MalaCards : Adrenal Cortex, Cortex, Pituitary, Adrenal Gland, Bone, Brain, Thyroid

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Publications for Adrenal Cortical Adenoma

Articles related to Adrenal Cortical Adenoma:

(show top 50) (show all 1068)

#	Title	Authors	PMID	Year
1	MEN I gene mutations in sporadic adrenal adenomas. ⁵	Schulte KM...Roher HD	10647896	1999
2	Biallelic APC inactivation was responsible for functional adrenocortical adenoma in familial adenomatous polyposis with novel germline mutation of the APC gene: report of a case. ⁵³ ⁶²	Hosogi H...Sakai Y	19684041	2009
3	Detection of somatic beta-catenin mutations in primary pigmented nodular adrenocortical disease (PPNAD). ⁵³ ⁶²	Tadjine M...Bourdeau I	18419788	2008
4	The role of immunohistochemistry in histopathological diagnostics of clinically "silent" incidentally detected adrenal masses. ⁵³ ⁶²	Babinska A...Jaskiewicz K	18393131	2008
5	Unique association of non-functioning pheochromocytoma, ganglioneuroma, adrenal cortical adenoma, hepatic and vertebral hemangiomas in a patient with a new intronic variant in the VHL gene. ⁵³ ⁶²	Bernini GP...Salvetti A	16483185	2005
6	Significance of inhibin in reproductive pathophysiology and current clinical applications. ⁵³ ⁶²	Kumanov P...Agarwal A	15970011	2005
7	Analysis of somatic APC mutations in rare extracolonic tumors of patients with familial adenomatous polyposis coli. ⁵³ ⁶²	Blaker H...Helmke BM	15287021	2004
8	Myxoid adrenocortical adenoma with a pseudoglandular pattern. ⁵³ ⁶²	Bollito ER...Mikuz G	15235911	2004
9	Primary hyperparathyroidism associatiated with aldosterone-producing adrenocortical adenoma and breast cancer: relation to MEN1 gene. ⁵³ ⁶²	Honda M...Ishibashi M	15168774	2004
10	[The expression of A103 and inhibin alpha in adrenocortical adenoma by high-throughput tissue microarray techniques]. ⁵³ ⁶²	Zhang H...Liao D	12910679	2003
11	Massive adrenocortical adenoma following long-term treatment of 21-hydroxylase deficiency. ⁵³ ⁶²	Takahashi S...Kitamura T	11832743	2002
12	Immunoexpression of inhibin alpha-subunit in adrenal neoplasms. ⁵³ ⁶²	Cho EY...Ahn GH	11556749	2001
13	Expression of adrenocorticotropin receptor gene in adrenocortical adenomas from patients with Cushing syndrome: possible contribution for the autonomous production of cortisol. ⁵³ ⁶²	Imai T...Seo H	11420487	2001
14	Food-dependent androgen and cortisol secretion by a gastric inhibitory polypeptide-receptor expressive adrenocortical adenoma leading to hirsutism and subclinical Cushing's syndrome: in vivo and in vitro studies. ⁵³ ⁶²	Tsagarakis S...Thalassinos N	11158012	2001
15	Virilizing adrenocortical adenoma: in vitro steroidogenesis, immunohistochemical studies of steroidogenic enzymes, and gene expression of corticotropin receptor. ⁵³ ⁶²	Imai T...Funahashi H	10216530	1999
16	Gene expression and roles of angiotensin II type 1 and type 2 receptors in human adrenals. ⁵³ ⁶²	Tanabe A...Demura H	9761377	1998
17	[Aberrant expression of the GIP (Gastric Inhibitory Polypeptide) receptor in an adrenal cortical adenoma responsible for a case of food-dependent Cushing's syndrome]. ⁵³ ⁶²	Luton JP...Bertagna X	10333644	1998
18	Aldosterone-producing adrenocortical adenoma complicated by chronic renal failure. Case report and review of the literature. ⁵³ ⁶²	Ito H...Hishimoto K	9845833	1998
19	Evaluation of plasma aldosterone to plasma renin activity ratio in patients with primary aldosteronism. ⁵³ ⁶²	Ignatowska-Switalska H...Lewandowski J	9249232	1997
20	Oestrogen producing adrenocortical adenoma: clinical, biochemical and immunohistochemical studies. ⁵³ ⁶²	Goto T...Sasano H	8977764	1996
21	Immunolocalization of dehydroepiandrosterone sulfotransferase in normal and pathologic human adrenal gland. ⁵³ ⁶²	Sasano H...Coughtrie MW	8751327	1995
22	Expression of a high molecular weight form of insulin-like growth factor II in a Beckwith-Wiedemann syndrome associated adrenocortical adenoma. ⁵³ ⁶²	Schofield PN...Zapf J	7621447	1995
23	In-vitro evidence for the regulation of 17,20-lyase activity by cytochrome b5 in adrenocortical adenomas from patients with Cushing's syndrome. ⁵³ ⁶²	Sakai Y...Nawata H	8137519	1994
24	Mechanism of abnormal production of adrenal androgens in patients with adrenocortical adenomas and carcinomas. ⁵³ ⁶²	Sakai Y...Nawata H	8288710	1994
25	Disordered expression of adrenal steroidogenic P450 mRNAs in incidentally discovered nonfunctioning adrenal adenoma. ⁵³ ⁶²	Ogo A...Nawata H	1535042	1992
26	Decreased levels of steroid 21-hydroxylase [P450(c21)] and its mRNA in an adrenocortical adenoma associated with 21-hydroxylase deficiency. ⁵³ ⁶²	Haji M...Nawata H	2101789	1990
27	Endocrine activity of the "silent" adrenocortical adenoma is uncovered by response to corticotropin-releasing hormone. ⁵³ ⁶²	Hensen J...Oelkers W	2165544	1990
28	68Ga-DOTATATE PET/CT of ACTH-Independent Cushing Syndrome Due to Ectopic Adrenocortical Adenoma. ⁶²	Jiang Y...Zhu Z	36469068	2023
29	Adrenocortical adenoma arising from adreno-hepatic fusion: A pitfall for an overdiagnosis. ⁶²	Inoue E...Itoh T	36468827	2022
30	Left adrenal aldosteronism coexisting with left paraaortic paraganglioma presenting as bilateral adrenal and left paraaortic tumors- comprehensive adrenal evaluation aiding perfect management: a case report. ⁶²	Hsu YC...Hung CJ	36371163	2022
31	Adrenal Cushing's Syndrome Treated With Preoperative Osilodrostat and Adrenalectomy. ⁶²	Malik RB...Ben-Shlomo A	36447826	2022
32	Approach to Fine Needle Aspiration of Adrenal Gland Lesions. ⁶²	Cantley RL	35878423	2022
33	Altered expression of the IGF2‑H19 locus and mitochondrial respiratory complexes in adrenocortical carcinoma. ⁶²	Scicluna P...Larsson C	36169175	2022
34	Imaging of C-X-C Motif Chemokine Receptor 4 Expression in 690 Patients with Solid or Hematologic Neoplasms Using 68Ga-Pentixafor PET. ⁶²	Buck AK...Werner RA	35241482	2022
35	Mixed ganglioneuroma and cortical adenoma in adrenal gland: A case report. ⁶²	Kang YN	36451378	2022
36	Prevalence and Characteristics of Adrenal Tumors in an Unselected Screening Population : A Cross-Sectional Study. ⁶²	Jing Y...Yang S	36095315	2022
37	Diagnostic and prognostic utility of SF-1 in adrenal cortical tumours. ⁶²	Maity P...Chatterjee U	36308186	2022
38	A 15-cm Adrenal Incidentaloma Suggested on Upper Endoscopy and Resected Laparoscopically. ⁶²	Saleh S...Safadi MF	36381726	2022
39	Adrenal myelolipoma: Defining the role of surgery. A case report. ⁶²	Steka X...Renzulli P	36030765	2022
40	Exploratory Circular RNA Profiling in Adrenocortical Tumors. ⁶²	Turai PI...Igaz P	36077848	2022
41	Retroperitoneal Bronchogenic Cyst Adjacent to Adrenocortical Adenoma. ⁶²	Toi N...Emoto M	35185056	2022
42	ACTH-independent production of 11-oxygenated androgens and glucocorticoids in an adrenocortical adenoma. ⁶²	Kitamura T...Tagami T	36165744	2022
43	Genetic Dissection of Primary Aldosteronism in a Patient with MEN1 and Ipsilateral Adrenocortical Carcinoma and Adenoma. ⁶²	Salle SP...Bourdeau I	36179244	2022
44	ACTH-Independent Cushing's Syndrome Caused by an Ectopic Adrenocortical Adenoma in the Renal Hilum. ⁶²	Hao Z...Luo Y	36010286	2022
45	Association of DNA methylation with steroidogenic enzymes in Cushing's adenoma. ⁶²	Kodama T...Hattori N	35675123	2022
46	Myelolipoma/extramedullary hematopoiesis within adrenal cortical adenoma increased in size during chronic myelogenous leukemia treatment. ⁶²	Baek J...Gu MJ	35088173	2022
47	Association of Nrf2 expression and mutation with Weiss and Helsinki scores in adrenocortical carcinoma. ⁶²	Kamai T...Kijima T	35467062	2022
48	Adrenal gland cytology reporting: a multi-institutional proposal for a standardized reporting system. ⁶²	Trabzonlu L...Barkan GA	35244974	2022
49	Semi-automated validation and quantification of CTLA-4 in 90 different tumor entities using multiple antibodies and artificial intelligence. ⁶²	Dum D...Blessin NC	35091676	2022
50	CT-based Abdominal Adipose Tissue Area Changes in Patients Undergoing Adrenalectomy Due to Cushing's Syndrome and Non-functioning Adenomas. ⁶²	Gundogdu E...Emekli E	34359077	2022

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Genes for Adrenal Cortical Adenoma

Genes related to Adrenal Cortical Adenoma (1 elite genes):

(show all 25)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubMed IDs
1	MEN1	Menin 1	Protein Coding	412.49	Pathogenic ⁵ DISEASES inferred ¹⁴ Novoseek inferred ⁵³	10647896 15168774
2	SYP	Synaptophysin	Protein Coding	22.02	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	19755404 20154585 15235911
3	GIPR	Gastric Inhibitory Polypeptide Receptor	Protein Coding	21.03	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	10333644 11158012
4	PRKAR1A	Protein Kinase CAMP-Dependent Type I Regulatory Subunit Alpha	Protein Coding	17.39	DISEASES inferred ¹⁴ Novoseek inferred ⁵³	16001332 16189167 16192737 (more) 15591278
5	CYP11B1	Cytochrome P450 Family 11 Subfamily B Member 1	Protein Coding	17.2	DISEASES inferred ¹⁴ Novoseek inferred ⁵³	1820978 1535042
6	NR5A1	Nuclear Receptor Subfamily 5 Group A Member 1	Protein Coding	16.23	DISEASES inferred ¹⁴ Novoseek inferred ⁵³	11592817 7629233 9851803 (more) 20154585 11857908 20080844
7	CYP17A1	Cytochrome P450 Family 17 Subfamily A Member 1	Protein Coding	16.22	DISEASES inferred ¹⁴ Novoseek inferred ⁵³	1835446 1820978 9851803 (more) 11857908 11592817 9625451 19755404 1535042
8	MC2R	Melanocortin 2 Receptor	Protein Coding	15.93	DISEASES inferred ¹⁴ Novoseek inferred ⁵³	11420487 10216530 11004727
9	POMC	Proopiomelanocortin	Protein Coding	15.29	DISEASES inferred ¹⁴ Novoseek inferred ⁵³	11420487 10216530
10	CYP21A2	Cytochrome P450 Family 21 Subfamily A Member 2	Protein Coding	14.87	DISEASES inferred ¹⁴ Novoseek inferred ⁵³	2101789 1820978 1535042 (more) 11832743
11	SULT2A1	Sulfotransferase Family 2A Member 1	Protein Coding	14.69	DISEASES inferred ¹⁴ Novoseek inferred ⁵³	8751327
12	INHA	Inhibin Subunit Alpha	Protein Coding	14.6	DISEASES inferred ¹⁴ Novoseek inferred ⁵³	12910679 11556749 15256108 (more) 15970011 15235911 10810286
13	CYP11A1	Cytochrome P450 Family 11 Subfamily A Member 1	Protein Coding	14.5	DISEASES inferred ¹⁴ Novoseek inferred ⁵³	1820978 1448379 1835446
14	IGF2	Insulin Like Growth Factor 2	Protein Coding	14.18	DISEASES inferred ¹⁴ Novoseek inferred ⁵³	11949624 7621447 9177379
15	MLANA	Melan-A	Protein Coding	13.29	DISEASES inferred ¹⁴ Novoseek inferred ⁵³	9422316
16	REN	Renin	Protein Coding	13.29	DISEASES inferred ¹⁴ Novoseek inferred ⁵³	9845833 1820978 9249232
17	NR2F1	Nuclear Receptor Subfamily 2 Group F Member 1	Protein Coding	12.65	DISEASES inferred ¹⁴ Novoseek inferred ⁵³	9851803
18	CHGA	Chromogranin A	Protein Coding	12.53	DISEASES inferred ¹⁴ Novoseek inferred ⁵³	15296477 15648545 15850005
19	MIR483	MicroRNA 483	RNA Gene	12.18	DISEASES inferred ¹⁴ ¹⁴
20	CYB5A	Cytochrome B5 Type A	Protein Coding	11.89	DISEASES inferred ¹⁴ Novoseek inferred ⁵³	9625451 8496319 8137519
21	ENO2	Enolase 2	Protein Coding	11.8	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
22	CDKN1C	Cyclin Dependent Kinase Inhibitor 1C	Protein Coding	11.35	DISEASES inferred ¹⁴ Novoseek inferred ⁵³	11454518 9177379
23	CTNNB1	Catenin Beta 1	Protein Coding	11.31	DISEASES inferred ¹⁴ Novoseek inferred ⁵³	16140927 18419788 17854394 (more) 18647815 19684041 15287021 19498322 19068395
24	SDHD	Succinate Dehydrogenase Complex Subunit D	Protein Coding	11.31	DISEASES inferred ¹⁴ Novoseek inferred ⁵³	19522821
25	SDHC	Succinate Dehydrogenase Complex Subunit C	Protein Coding	10.91	DISEASES inferred ¹⁴ Novoseek inferred ⁵³	19522821

Sources

Variations for Adrenal Cortical Adenoma

ClinVar genetic disease variations for Adrenal Cortical Adenoma:

⁵

#	Gene	Name	Type	Significance	ClinVarId	dbSNP ID	Position
1	MEN1	NM_001370259.2(MEN1):c.1654A>T (p.Thr552Ser)	SNV	Pathogenic	16698	rs121913035	GRCh37: 11:64571985-64571985 GRCh38: 11:64804513-64804513

Cosmic variations for Adrenal Cortical Adenoma:

⁸ (show top 50) (show all 118)

#	Cosmic Mut ID	Gene Symbol	COSMIC Disease Classification (Primary site, Site subtype, Primary histology, Histology subtype)	Mutation CDS	Mutation AA	GRCh38 Location	Conf
1	COSM86624499	RB1	pituitary,NS,adenoma,ACTH-FSH-GH-LH-PRL	c.1861C>A	p.R621S	13:48456250-48456250	7
2	COSM150337228	CTNNB1	pituitary,NS,adenoma,ACTH-FSH	c.127G>C	p.A43P	3:41224639-41224639	7
3	COSM151605250	CTNNB1	pituitary,NS,adenoma,ACTH-FSH	c.127G>C	p.A43P	3:41224639-41224639	7
4	COSM150962042	CTNNB1	pituitary,NS,adenoma,ACTH-FSH-LH-alpha SU	c.113C>A	p.S38Y	3:41224646-41224646	7
5	COSM151491351	CTNNB1	pituitary,NS,adenoma,ACTH-FSH-LH	c.112T>C	p.S38P	3:41224645-41224645	7
6	COSM105887915	CTNNB1	pituitary,NS,adenoma,ACTH-FSH-LH	c.133T>C	p.S45P	3:41224645-41224645	7
7	COSM110179104	CTNNB1	pituitary,NS,adenoma,ACTH-FSH-LH	c.133T>C	p.S45P	3:41224645-41224645	7
8	COSM150547790	CTNNB1	pituitary,NS,adenoma,ACTH-FSH	c.127G>C	p.A43P	3:41224639-41224639	7
9	COSM150961028	CTNNB1	pituitary,NS,adenoma,ACTH-FSH-LH	c.112T>C	p.S38P	3:41224645-41224645	7
10	COSM111910236	CTNNB1	pituitary,NS,adenoma,ACTH-FSH	c.127G>C	p.A43P	3:41224639-41224639	7
11	COSM102452270	CTNNB1	pituitary,NS,adenoma,ACTH-FSH-LH-alpha SU	c.134C>A	p.S45Y	3:41224646-41224646	7
12	COSM150526110	CTNNB1	pituitary,NS,adenoma,ACTH-FSH-LH	c.133T>C	p.S45P	3:41224645-41224645	7
13	COSM151827775	CTNNB1	pituitary,NS,adenoma,ACTH-FSH-LH-alpha SU	c.134C>A	p.S45Y	3:41224646-41224646	7
14	COSM150088294	CTNNB1	pituitary,NS,adenoma,ACTH-FSH-LH	c.112T>C	p.S38P	3:41224645-41224645	7
15	COSM102412283	CTNNB1	pituitary,NS,adenoma,ACTH-FSH	c.127G>C	p.A43P	3:41224639-41224639	7
16	COSM110181025	CTNNB1	pituitary,NS,adenoma,ACTH-FSH-LH-alpha SU	c.134C>A	p.S45Y	3:41224646-41224646	7
17	COSM150300123	CTNNB1	pituitary,NS,adenoma,ACTH-FSH	c.127G>C	p.A43P	3:41224639-41224639	7
18	COSM146902958	CTNNB1	pituitary,NS,adenoma,ACTH-FSH	c.127G>C	p.A43P	3:41224639-41224639	7
19	COSM150454007	CTNNB1	pituitary,NS,adenoma,ACTH-FSH-LH-alpha SU	c.134C>A	p.S45Y	3:41224646-41224646	7
20	COSM151356165	CTNNB1	pituitary,NS,adenoma,ACTH-FSH	c.106G>C	p.A36P	3:41224639-41224639	7
21	COSM150480970	CTNNB1	pituitary,NS,adenoma,ACTH-FSH	c.127G>C	p.A43P	3:41224639-41224639	7
22	COSM150141897	CTNNB1	pituitary,NS,adenoma,ACTH-FSH-LH	c.133T>C	p.S45P	3:41224645-41224645	7
23	COSM151979920	CTNNB1	pituitary,NS,adenoma,ACTH-FSH-LH-alpha SU	c.134C>A	p.S45Y	3:41224646-41224646	7
24	COSM151836221	CTNNB1	pituitary,NS,adenoma,ACTH-FSH	c.127G>C	p.A43P	3:41224639-41224639	7
25	COSM111893529	CTNNB1	pituitary,NS,adenoma,ACTH-FSH-LH	c.112T>C	p.S38P	3:41224645-41224645	7
26	COSM150660304	CTNNB1	pituitary,NS,adenoma,ACTH-FSH-LH-alpha SU	c.134C>A	p.S45Y	3:41224646-41224646	7
27	COSM146245709	CTNNB1	pituitary,NS,adenoma,ACTH-FSH-LH-alpha SU	c.134C>A	p.S45Y	3:41224646-41224646	7
28	COSM111894601	CTNNB1	pituitary,NS,adenoma,ACTH-FSH-LH-alpha SU	c.113C>A	p.S38Y	3:41224646-41224646	7
29	COSM150867955	CTNNB1	pituitary,NS,adenoma,ACTH-FSH-LH	c.112T>C	p.S38P	3:41224645-41224645	7
30	COSM151353823	CTNNB1	pituitary,NS,adenoma,ACTH-FSH	c.106G>C	p.A36P	3:41224639-41224639	7
31	COSM111038093	CTNNB1	pituitary,NS,adenoma,ACTH-FSH-LH-alpha SU	c.134C>A	p.S45Y	3:41224646-41224646	7
32	COSM102485110	CTNNB1	pituitary,NS,adenoma,ACTH-FSH	c.127G>C	p.A43P	3:41224639-41224639	7
33	COSM151345590	CTNNB1	pituitary,NS,adenoma,ACTH-FSH-LH-alpha SU	c.113C>A	p.S38Y	3:41224646-41224646	7
34	COSM150868805	CTNNB1	pituitary,NS,adenoma,ACTH-FSH-LH-alpha SU	c.113C>A	p.S38Y	3:41224646-41224646	7
35	COSM151592258	CTNNB1	pituitary,NS,adenoma,ACTH-FSH-LH-alpha SU	c.134C>A	p.S45Y	3:41224646-41224646	7
36	COSM150274829	CTNNB1	pituitary,NS,adenoma,ACTH-FSH-LH	c.133T>C	p.S45P	3:41224645-41224645	7
37	COSM102450402	CTNNB1	pituitary,NS,adenoma,ACTH-FSH-LH	c.133T>C	p.S45P	3:41224645-41224645	7
38	COSM102380394	CTNNB1	pituitary,NS,adenoma,ACTH-FSH-LH-alpha SU	c.134C>A	p.S45Y	3:41224646-41224646	7
39	COSM150827985	CTNNB1	pituitary,NS,adenoma,ACTH-FSH	c.127G>C	p.A43P	3:41224639-41224639	7
40	COSM151559313	CTNNB1	pituitary,NS,adenoma,ACTH-FSH-LH-alpha SU	c.134C>A	p.S45Y	3:41224646-41224646	7
41	COSM110212608	CTNNB1	pituitary,NS,adenoma,ACTH-FSH	c.127G>C	p.A43P	3:41224639-41224639	7
42	COSM150452305	CTNNB1	pituitary,NS,adenoma,ACTH-FSH-LH	c.133T>C	p.S45P	3:41224645-41224645	7
43	COSM151343442	CTNNB1	pituitary,NS,adenoma,ACTH-FSH-LH	c.112T>C	p.S38P	3:41224645-41224645	7
44	COSM151344333	CTNNB1	pituitary,NS,adenoma,ACTH-FSH-LH-alpha SU	c.113C>A	p.S38Y	3:41224646-41224646	7
45	COSM151570765	CTNNB1	pituitary,NS,adenoma,ACTH-FSH	c.127G>C	p.A43P	3:41224639-41224639	7
46	COSM149991639	CTNNB1	pituitary,NS,adenoma,ACTH-FSH	c.106G>C	p.A36P	3:41224639-41224639	7
47	COSM146867471	CTNNB1	pituitary,NS,adenoma,ACTH-FSH-LH	c.133T>C	p.S45P	3:41224645-41224645	7
48	COSM149959645	CTNNB1	pituitary,NS,adenoma,ACTH-FSH-LH-alpha SU	c.113C>A	p.S38Y	3:41224646-41224646	7
49	COSM111917881	CTNNB1	pituitary,NS,adenoma,ACTH-FSH	c.106G>C	p.A36P	3:41224639-41224639	7
50	COSM151826992	CTNNB1	pituitary,NS,adenoma,ACTH-FSH-LH	c.133T>C	p.S45P	3:41224645-41224645	7

Sources

Expression for Adrenal Cortical Adenoma

Search GEO for disease gene expression data for Adrenal Cortical Adenoma.

Sources

Pathways for Adrenal Cortical Adenoma

Pathways related to Adrenal Cortical Adenoma according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Metapathway biotransformation Phase I and II ⁷⁴ Show member pathways Acetaminophen metabolism ²² Aflatoxin B1 metabolism ⁷⁴ Artemisinin and Derivatives Pathway, Pharmacokinetics ⁶⁰ Arylamine metabolism ⁷⁴ Benzo(a)pyrene metabolism ⁷⁴ Benzo[a]pyrene metabolism ²² Benzodiazepine Pathway, Pharmacokinetics ⁶⁰ Biological oxidations ⁶⁶ Cannabidiol Pathway, Pharmacokinetics ⁶⁰ Doxepin Pathway, Pharmacokinetics ⁶⁰ Estradiol metabolism ²² Flurbiprofen Pathway, Pharmacokinetics ⁶⁰ Haloperidol Pathway, Pharmacokinetics ⁶⁰ Methylation ⁶⁶ Naproxen Pathway, Pharmacokinetics ⁶⁰ Phase II - Conjugation of compounds ⁶⁶ Phenprocoumon Pathway, Pharmacokinetics ⁶⁰ Sorafenib Pharmacokinetics ⁶⁰ Tamoxifen Pathway, Pharmacokinetics ⁶⁰ Voriconazole Pathway, Pharmacokinetics ⁶⁰	12.77	SULT2A1 POMC CYP21A2 CYP17A1 CYP11B1 CYP11A1
2	Diseases of glycosylation ⁶⁶ Show member pathways Defective ALG1 causes CDG-1k ⁶⁶ Defective ALG11 causes CDG-1p ⁶⁶ Defective ALG12 causes CDG-1g ⁶⁶ Defective ALG14 causes ALG14-CMS ⁶⁶ Defective ALG2 causes CDG-1i ⁶⁶ Defective ALG3 causes CDG-1d ⁶⁶ Defective ALG6 causes CDG-1c ⁶⁶ Defective ALG8 causes CDG-1h ⁶⁶ Defective ALG9 causes CDG-1l ⁶⁶ Defective DPAGT1 causes CDG-1j, CMSTA2 ⁶⁶ Defective GNE causes sialuria, NK and IBM2 ⁶⁶ Defective MPDU1 causes CDG-1f ⁶⁶ Defective NEU1 causes sialidosis ⁶⁶ Defective RFT1 causes CDG-1n ⁶⁶ Diseases associated with glycosylation precursor biosynthesis ⁶⁶ Diseases associated with N-glycosylation of proteins ⁶⁶ Diseases of metabolism ⁶⁶ MPS IV - Morquio syndrome B ⁶⁶	12.49	CYP11A1 CYP11B1 CYP17A1 CYP21A2 MC2R POMC
3	Oxidation by cytochrome P450 ⁷⁴ Show member pathways Amine Oxidase reactions ⁶⁶ Aryl hydrocarbon receptor signalling ⁶⁶ Atomoxetine Pathway, Pharmacokinetics ⁶⁰ Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB ⁶⁶ Celecoxib Pathway, Pharmacokinetics ⁶⁰ Cyclophosphamide Pathway, Pharmacokinetics ⁶⁰ CYP2E1 reactions ⁶⁶ Cytochrome P450 - arranged by substrate type ⁶⁶ Defective CYP24A1 causes HCAI ⁶⁶ Defective CYP26B1 causes RHFCA ⁶⁶ Defective CYP26C1 causes FFDD4 ⁶⁶ Defective CYP27A1 causes CTX ⁶⁶ Defective CYP27B1 causes VDDR1A ⁶⁶ Defective CYP27B1 causes VDDR1B ⁶⁶ Defective CYP4F22 causes ARCI5 ⁶⁶ Defective MAOA causes BRUNS ⁶⁶ Eicosanoids ⁶⁶ Endogenous sterols ⁶⁶ Ethanol oxidation ⁶⁶ Fatty acid omega-oxidation ⁷⁴ Fatty acids ⁶⁶ Fluvoxamine Pathway, Pharmacokinetics ⁶⁰ Lidocaine Pathway, Pharmacokinetics ⁶⁰ Miscellaneous substrates ⁶⁶ Phase I - Functionalization of compounds ⁶⁶ Prasugrel Pathway, Pharmacokinetics ⁶⁰ Sterols are 12-hydroxylated by CYP8B1 ⁶⁶ Vitamin D2 (ergocalciferol) metabolism ²² Vitamins ⁶⁶ Xenobiotics ⁶⁶	12.44	POMC CYP21A2 CYP17A1 CYP11B1 CYP11A1 CYB5A
4	Metabolism of steroids ⁶⁶ Show member pathways Activation of gene expression by SREBF (SREBP) ⁶⁶ allopregnanolone biosynthesis ⁶¹ androgen biosynthesis ⁶¹ Cholesterol synthesis disorders ⁷⁴ Defective CYP17A1 causes AH5 ⁶⁶ Regulation of cholesterol biosynthesis by SREBP (SREBF) ⁶⁶ Sterol regulatory element-binding proteins (SREBP) signaling ⁷⁴ Vitamin D (calciferol) metabolism ⁶⁶	12.36	POMC CYP21A2 CYP17A1 CYP11B1 CYP11A1
5	G alpha (s) signalling events ⁶⁶ Show member pathways Defective ACTH causes obesity and POMCD ⁶⁶	11.94	PRKAR1A POMC MC2R GIPR
6	Androstenedione and testosterone biosynthesis and metabolism p.1 ²² Show member pathways Estrogen biosynthesis ²² Estrone metabolism ²² Steroid biosynthesis ⁷⁴	11.39	SULT2A1 CYP17A1 CYP11B1
7	Metabolism of steroid hormones ⁶⁶ Show member pathways Androgen biosynthesis ⁶⁶ Defective CYP11A1 causes AICSR ⁶⁶ Defective CYP11B1 causes AH4 ⁶⁶ Defective CYP21A2 causes AH3 ⁶⁶ Electron transport from NADPH to Ferredoxin ⁶⁶ Estrogen biosynthesis ⁶⁶ Glucocorticoid and Mineralcorticoid Metabolism ⁷⁴ Glucocorticoid biosynthesis ⁶⁶ Mineralocorticoid biosynthesis ⁶⁶ Pregnenolone biosynthesis ⁶⁶	11.34	POMC CYP21A2 CYP17A1 CYP11B1 CYP11A1
8	Metabolic disorders of biological oxidation enzymes ⁶⁶	10.99	CYP21A2 CYP17A1 CYP11B1 CYP11A1
9	Corticotropin-releasing hormone signaling pathway ⁷⁴	10.98	SULT2A1 POMC CYP21A2 CYP11B1 CYP11A1
10	Alternative pathway of fetal androgen synthesis ⁷⁴	10.47	CYP17A1 CYP11A1 CYB5A

Sources

GO Terms for Adrenal Cortical Adenoma

Biological processes related to Adrenal Cortical Adenoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	regulation of blood pressure	GO:0008217	9.92	REN POMC CYP11B1 CHGA
2	sterol metabolic process	GO:0016125	9.85	CYP21A2 CYP11B1 CYP11A1
3	C21-steroid hormone biosynthetic process	GO:0006700	9.73	CYP11B1 CYP11A1
4	cellular response to peptide hormone stimulus	GO:0071375	9.73	CYP11A1 CYP11B1 MEN1
5	cortisol metabolic process	GO:0034650	9.71	CYP11B1 CYP11A1
6	steroid biosynthetic process	GO:0006694	9.63	CYP21A2 CYP17A1 CYP11B1 CYP11A1
7	steroid metabolic process	GO:0008202	9.56	SULT2A1 CYP21A2 CYP17A1 CYP11B1 CYP11A1
8	glucocorticoid biosynthetic process	GO:0006704	9.23	CYP21A2 CYP17A1 CYP11B1 CYP11A1

Molecular functions related to Adrenal Cortical Adenoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	iron ion binding	GO:0005506	9.86	CYP21A2 CYP17A1 CYP11B1 CYP11A1
2	heme binding	GO:0020037	9.65	CYP21A2 CYP17A1 CYP11B1 CYP11A1 CYB5A
3	monooxygenase activity	GO:0004497	9.46	CYP21A2 CYP17A1 CYP11B1 CYP11A1
4	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	GO:0016705	8.92	CYP21A2 CYP17A1 CYP11B1 CYP11A1