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MCID: ADR041
MIFTS: 46

Adrenal Cortical Adenoma

Categories: Cancer diseases, Endocrine diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Adrenal Cortical Adenoma

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MalaCards integrated aliases for Adrenal Cortical Adenoma:

Name: Adrenal Cortical Adenoma 12 15 73
Adrenocortical Adenoma 12 29
Adenoma Adrenocortical 55

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Endocrine diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:0050891
UMLS 73 C0206667
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Summaries for Adrenal Cortical Adenoma

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Disease Ontology : 12 An adrenal adenoma that is a benign tumor of the adrenal cortex.

MalaCards based summary : Adrenal Cortical Adenoma, also known as adrenocortical adenoma, is related to conn's syndrome and adrenal adenoma. An important gene associated with Adrenal Cortical Adenoma is SYP (Synaptophysin), and among its related pathways/superpathways are Cytochrome P450 - arranged by substrate type and DAG and IP3 signaling. The drugs Racepinephrine and Epinephrine have been mentioned in the context of this disorder. Affiliated tissues include cortex, adrenal cortex and adrenal gland, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Wikipedia : 76 A adrenocortical adenoma (or adrenal cortical adenoma, or sometimes simply adrenal adenoma) is a benign... more...

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Related Diseases for Adrenal Cortical Adenoma

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Diseases related to Adrenal Cortical Adenoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 95)
# Related Disease Score Top Affiliating Genes
1 conn's syndrome 31.1 CYP11A1 CYP11B1 CYP17A1 CYP21A2 GIPR MC2R
2 adrenal adenoma 31.0 CYP11A1 CYP11B1 CYP17A1 CYP21A2 GIPR MC2R
3 adrenal carcinoma 30.7 CYP11A1 CYP11B1 CYP17A1 CYP21A2 NR5A1 POMC
4 primary pigmented nodular adrenocortical disease 30.1 POMC PRKAR1A SYP
5 pseudohermaphroditism 29.8 CYP17A1 NR5A1
6 hyperandrogenism 29.7 CYP17A1 CYP21A2 POMC
7 lipoid congenital adrenal hyperplasia 28.9 CYP11A1 CYP11B1 CYP17A1 CYP21A2 MC2R NR5A1
8 adrenocortical carcinoma, hereditary 27.9 CYP11A1 CYP11B1 CYP17A1 CYP21A2 MC2R NR5A1
9 adenoma 10.8
10 pheochromocytoma 10.4
11 gangliocytoma 10.2 POMC SYP
12 spermatocele 10.2 NR5A1 SYP
13 sertoli cell tumor 10.2 PRKAR1A SYP
14 pancreatic endocrine carcinoma 10.2 POMC SYP
15 sella turcica neoplasm 10.2 POMC SYP
16 tuberculum sellae meningioma 10.2 POMC SYP
17 olfactory nerve neoplasm 10.2 POMC SYP
18 myxosarcoma 10.2 PRKAR1A SYP
19 abducens nerve disease 10.1 POMC SYP
20 cervix small cell carcinoma 10.1 POMC SYP
21 hyperaldosteronism, familial, type i 10.1 CYP11B1 POMC
22 cranial nerve malignant neoplasm 10.1 POMC SYP
23 ectopic cushing syndrome 10.1 POMC SYP
24 familial adenomatous polyposis 10.1
25 classic congenital adrenal hyperplasia due to 21-hydroxylase deficiency 10.1 CYP21A2 POMC
26 glucocorticoid deficiency 1 10.1 MC2R POMC
27 endocrine organ benign neoplasm 10.1 CYP11B1 POMC SYP
28 achalasia-addisonianism-alacrima syndrome 10.1 MC2R POMC
29 transsexualism 10.1 CYP17A1 CYP21A2
30 sex cord-gonadal stromal tumor 10.1 NR5A1 POMC SYP
31 renal cell carcinoma, nonpapillary 10.1
32 angiosarcoma 10.1
33 ganglioneuroma 10.1
34 familial glucocorticoid deficiency 10.0 MC2R POMC
35 antley-bixler syndrome 10.0 CYP17A1 CYP21A2
36 adrenal hyperplasia, congenital, due to 21-hydroxylase deficiency 10.0
37 thyroiditis 10.0
38 precocious puberty 10.0
39 pituitary adenoma, prolactin-secreting 10.0 POMC PRKAR1A
40 pituitary-dependent cushing's disease 10.0 CYP21A2 POMC
41 cell type benign neoplasm 10.0 POMC SYP
42 male reproductive organ benign neoplasm 9.9 NR5A1 POMC PRKAR1A SYP
43 cytochrome p450 oxidoreductase deficiency 9.9 CYP17A1 CYP21A2 POMC
44 gonadal disease 9.9 NR5A1 POMC SULT2A1
45 beckwith-wiedemann syndrome 9.9
46 multiple endocrine neoplasia, type i 9.9
47 hypertension, essential 9.9
48 carney triad 9.9
49 hyperparathyroidism 9.9
50 adenomatoid tumor 9.9

Graphical network of the top 20 diseases related to Adrenal Cortical Adenoma:



Diseases related to Adrenal Cortical Adenoma
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Symptoms & Phenotypes for Adrenal Cortical Adenoma

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GenomeRNAi Phenotypes related to Adrenal Cortical Adenoma according to GeneCards Suite gene sharing:

26 (show all 15)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-109 10.27 SULT2A1
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-139 10.27 CYP21A2
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-142 10.27 SULT2A1
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-145 10.27 CYP21A2
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-173 10.27 NR5A1
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-175 10.27 SULT2A1
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-184 10.27 CYP11A1 CYP21A2 NR5A1
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-203 10.27 CYP11A1 CYP21A2 SULT2A1
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-206 10.27 CYP21A2
10 Decreased shRNA abundance (Z-score < -2) GR00366-A-213 10.27 CYP21A2
11 Decreased shRNA abundance (Z-score < -2) GR00366-A-28 10.27 CYP11A1
12 Decreased shRNA abundance (Z-score < -2) GR00366-A-33 10.27 SULT2A1
13 Decreased shRNA abundance (Z-score < -2) GR00366-A-94 10.27 SULT2A1
14 Increased transferrin (TF) endocytosis GR00363-A 9.56 CYP11A1 CYP11B1 CYP21A2 GIPR MC2R POMC
15 Reduced mammosphere formation GR00396-S 9.02 CYP11B1 CYP21A2 GIPR MC2R POMC

MGI Mouse Phenotypes related to Adrenal Cortical Adenoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.76 CYP11A1 CYP11B1 CYP17A1 MC2R NR5A1 POMC
2 endocrine/exocrine gland MP:0005379 9.5 CYP11A1 CYP11B1 GIPR MC2R NR5A1 POMC
3 homeostasis/metabolism MP:0005376 9.23 CYP11A1 CYP11B1 CYP17A1 GIPR MC2R NR5A1
Sources

Drugs & Therapeutics for Adrenal Cortical Adenoma

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Drugs for Adrenal Cortical Adenoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 81)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Racepinephrine Approved Phase 4,Phase 3,Phase 2,Not Applicable 329-65-7 838
2
Epinephrine Approved, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 51-43-4 5816
3 Neurotransmitter Agents Phase 4,Phase 3,Not Applicable
4 Anti-Asthmatic Agents Phase 4,Phase 3,Not Applicable
5 Adrenergic beta-Agonists Phase 4,Phase 3,Not Applicable
6 Respiratory System Agents Phase 4,Phase 3,Not Applicable
7 Autonomic Agents Phase 4,Phase 3,Phase 2,Not Applicable
8 Adrenergic alpha-Agonists Phase 4,Phase 3,Not Applicable
9 Mydriatics Phase 4,Phase 3,Not Applicable
10 Adrenergic Agonists Phase 4,Phase 3,Not Applicable
11 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Not Applicable
12 Adrenergic Agents Phase 4,Phase 3,Not Applicable
13 Epinephryl borate Phase 4,Phase 3,Phase 2,Not Applicable
14 Sympathomimetics Phase 4,Phase 3,Not Applicable
15 Bronchodilator Agents Phase 4,Phase 3,Not Applicable
16 Vasoconstrictor Agents Phase 4,Phase 3,Not Applicable
17
Hydrocortisone Approved, Vet_approved Phase 3,Phase 2,Not Applicable 50-23-7 5754
18
Hydrocortisone acetate Approved, Vet_approved Phase 3,Phase 2,Not Applicable 50-03-3
19
Mifepristone Approved, Investigational Phase 3 84371-65-3 55245
20
Etomidate Approved Phase 3 33125-97-2 667484 36339
21 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3,Phase 2,Not Applicable
22 Hormones Phase 3,Phase 2,Not Applicable
23 Hormone Antagonists Phase 3,Phase 2,Not Applicable
24 glucocorticoids Phase 3,Phase 2
25 Contraceptives, Oral Phase 3
26 Luteolytic Agents Phase 3
27 Contraceptive Agents Phase 3
28 beta-endorphin Phase 3
29 Contraceptives, Postcoital Phase 3
30 Melanocyte-Stimulating Hormones Phase 3
31 Hydrocortisone 17-butyrate 21-propionate Phase 3,Phase 2,Not Applicable
32 Cortisol succinate Phase 3,Phase 2,Not Applicable
33 Adrenocorticotropic Hormone Phase 3,Phase 2
34 Fluorodeoxyglucose F18 Phase 3
35 Central Nervous System Depressants Phase 3
36 Anesthetics Phase 3
37 Anesthetics, Intravenous Phase 3
38 Hypnotics and Sedatives Phase 3
39 Anesthetics, General Phase 3
40
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 2 1177-87-3
41
Dexamethasone Approved, Investigational, Vet_approved Phase 2 50-02-2 5743
42 Antineoplastic Agents, Hormonal Phase 2
43
protease inhibitors Phase 2
44 BB 1101 Phase 2
45 Antiemetics Phase 2
46 Anti-Inflammatory Agents Phase 2,Not Applicable
47 Gastrointestinal Agents Phase 2
48 HIV Protease Inhibitors Phase 2
49
Dopamine Approved 51-61-6, 62-31-7 681
50
Ethanol Approved 64-17-5 702

Interventional clinical trials:

(show all 34)
# Name Status NCT ID Phase Drugs
1 Influence of Synacthen Infusion on the Results of Adrenal Venous Sampling in Patient With Primary Aldosteronism Unknown status NCT02127840 Phase 4 Synacthen infusion during adrenal venous sampling
2 An Extension Study of CORLUX in the Treatment of Endogenous Cushing's Syndrome Completed NCT00936741 Phase 3 mifepristone
3 A Study of the Efficacy and Safety of CORLUX in the Treatment of Endogenous Cushing's Syndrome Completed NCT00569582 Phase 3 mifepristone
4 Combined FDG-PET and 123I-Iodometomidate Imaging for Adrenal Neoplasia Recruiting NCT02010957 Phase 3
5 A Study of the Efficacy and Safety of Relacorilant Recruiting NCT03697109 Phase 3 Relacorilant
6 Medical Safety Follow-up Study for Patients Who Received More Than 28 Days of Total Exposure to BGG492 Completed NCT02150213 Phase 2 BGG492
7 Study of Efficacy and Safety of Osilodrostat in Cushing's Syndrome Completed NCT02468193 Phase 2 Osilodrostat
8 Study to Evaluate CORT125134 in Patients With Cushing's Syndrome Completed NCT02804750 Phase 2 CORT125134
9 Extension Study to Evaluate the Safety and Clinical Benefit of Long-Term Use of Relacorilant in Patients With Cushing Syndrome Recruiting NCT03604198 Phase 2 relacorilant
10 Study of Adrenalectomy Versus Observation for Subclinical Hypercortisolism Terminated NCT02001051 Phase 2
11 Long-term Beneficial Metabolic Effects of Adrenalectomy in Subclinical Cushing's Syndrome of Adrenal Incidentaloma Unknown status NCT01382420 Not Applicable
12 Does Serum-DXM Increase Diagnostic Accuracy of the Overnight DXM Suppression Test in the Work-up of Cushing's Syndrome? Unknown status NCT01504555
13 D2 Dopamine Receptor on Human Aldosterone-Producing Adenoma and Its Role in Aldosterone Secretion and Cell Proliferation Unknown status NCT00173446
14 Cardiovascular Risk in Patients With Non-Functional Adrenal Incidentaloma Completed NCT00768365
15 Rare Cystic Benign Adrenal Incidentalomas Completed NCT03739918
16 Comparison Between Posterior Retroperitoneoscopic Adrenalectomy and Laparoscopic Adrenalectomy Completed NCT01676025 Not Applicable
17 Surgery of Subclinical Cortisol Secreting Adrenal Incidentalomas Recruiting NCT02364089 Not Applicable Standardized medical treatment of hypertension by SAHR
18 Structured Evaluation of adRENal Tumors Discovered Incidentally - Prospectively Investigating the Testing Yield Recruiting NCT02324647
19 Radiofrequency Endoscopic Ablation With Ultrasound Guidance: a Non-surgical Treatment for Aldosterone-producing Adenomas Recruiting NCT03405025 Not Applicable
20 Radiofrequency Ablation for Aldosterone-producting Adenoma in Patients With Primary Aldosteronism Recruiting NCT02756754 Not Applicable
21 Effect of Chronic Catecholamine Overproduction on Brown Adipose Tissue Recruiting NCT01949714
22 Adrenalectomy Versus Follow-up in Patients With Subclinical Cushings Syndrome Recruiting NCT01246739 Not Applicable
23 Quality of Life, Fatigue and Cognitive, Affective and Emotional Dysfunction in Patients With Cushing's Syndrome Recruiting NCT03211624
24 Clinical and Molecular Characteristics of Primary Aldosteronism in Blacks Recruiting NCT03374215
25 Glucose Metabolism in Subjects With Aldosterone-Producing Adenomas Recruiting NCT02362308 Not Applicable mineralocorticoid receptor antagonist
26 Renal Sympathetic Denervation From The Adventitia on Hypertension Recruiting NCT02642445 Not Applicable
27 Study of Adrenal Gland Tumors Recruiting NCT00005927
28 Prospective Study Assessing Blood Pressure and Other Outcomes Post-treatment in Patients With Primary Aldosteronism Recruiting NCT03174847 Mineralocorticoid Receptor Antagonists
29 Laparoscopic Adrenalectomy Versus Radiofrequency Ablation Active, not recruiting NCT02030587 Not Applicable
30 Expression of Different Proliferation Biomarkers in Adreno-cortical Tumors Active, not recruiting NCT02747355
31 A Prospective Cohort Study for Patients With Adrenal Diseases Not yet recruiting NCT03474237
32 Rapid Cortisol Assay in Adrenal Vein Sampling Not yet recruiting NCT03449797 Not Applicable
33 Macrolides for KCNJ5 - Mutated Aldosterone-Producing Adenoma (MAPA) Not yet recruiting NCT03414918 Not Applicable Clarithromycin
34 A Study to Confirm Recurrent or Persistent Cushing's Syndrome in Patients With Signs or Symptoms of Hypercortisolemia Terminated NCT00796783 Cushing's syndrome confirmation

Search NIH Clinical Center for Adrenal Cortical Adenoma

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Genetic Tests for Adrenal Cortical Adenoma

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Genetic tests related to Adrenal Cortical Adenoma:

# Genetic test Affiliating Genes
1 Adrenocortical Adenoma 29
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Anatomical Context for Adrenal Cortical Adenoma

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MalaCards organs/tissues related to Adrenal Cortical Adenoma:

41
Cortex, Adrenal Cortex, Adrenal Gland, Thyroid, Pituitary, Breast, Lung
Sources

Publications for Adrenal Cortical Adenoma

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Articles related to Adrenal Cortical Adenoma:

(show top 50) (show all 215)
# Title Authors Year
1
Florid hyperandrogenism due to a benign adrenocortical adenoma. ( 30061126 )
2018
2
Adrenocortical adenoma manifesting as false-positive iodine accumulation in a patient with history of thyroid carcinoma. ( 30108672 )
2018
3
An Ectopic Cortisol-Producing Adrenocortical Adenoma Masquerading as a Liposarcoma in the Pararenal Space. ( 30112868 )
2018
4
Tubulo-papillary adrenocortical adenoma in a patient with familial adenomatous polyposis: A morphologic, ultrastructural and molecular study. ( 30172912 )
2018
5
Does IGF-1 play a role in the etiopathogenesis of non-functioning adrenocortical adenoma? ( 29542030 )
2018
6
Tumor microenvironment in functional adrenocortical adenomas: immune cell infiltration in cortisol-producing adrenocortical adenoma. ( 29596893 )
2018
7
Rebound thymic hyperplasia after adrenalectomy in a patient with Cushing syndrome caused by adrenocortical adenoma: A case report. ( 29642186 )
2018
8
MiR-193a-3p functions as a tumour suppressor in human aldosterone-producing adrenocortical adenoma by down-regulating CYP11B2. ( 29665181 )
2018
9
Pheochromocytoma with Synchronous Ipsilateral Adrenal Cortical Adenoma. ( 28762170 )
2017
10
Spinal adrenal cortical adenoma associated with Beckwith-Wiedemann syndrome: case report and review of the literature. ( 28365908 )
2017
11
Primary Hyperaldosteronism Due to Adrenocortical Adenoma: a Case Report. ( 29093236 )
2017
12
Enlarging hypermetabolic nodule: benign non-functional adrenocortical adenoma. ( 29248879 )
2017
13
A exceptional collision tumor of primary adrenal angiosarcoma and non-functioning adrenocortical adenoma. ( 28551383 )
2017
14
Myxoid Adrenocortical Adenoma: A report of two cases and literature review. ( 28559117 )
2017
15
Differentiating pheochromocytoma from lipid-poor adrenocortical adenoma by CT texture analysis: feasibility study. ( 28357529 )
2017
16
Ectopic adrenocortical adenoma in the renal hilum: a case report and literature review. ( 27094262 )
2016
17
Intrarenal Adrenocortical Adenoma Treated by Robotic Partial Nephrectomy with Adrenalectomy. ( 27579413 )
2016
18
Expression of CYP11B2 in Aldosterone-Producing Adrenocortical Adenoma: Regulatory Mechanisms and Clinical Significance. ( 27853054 )
2016
19
An Unusual Adrenal Cortical Nodule: Composite Adrenal Cortical Adenoma and Adenomatoid Tumor. ( 25861051 )
2015
20
Adrenal renal fusion confusion: a case report of an adrenal cortical adenoma with adrenal-renal fusion. ( 25757409 )
2015
21
Clinical and pathological analysis of 116 cases of adult adrenal cortical adenoma and literature review. ( 26064059 )
2015
22
Myxoid adrenal cortical adenoma in an infant: An unusual morphology. ( 26881659 )
2015
23
Cushing's syndrome during pregnancy caused by adrenal cortical adenoma: a case report and literature review. ( 26271293 )
2015
24
A Case Report of Adrenocortical Adenoma Mimicking Congenital Adrenal Hyperplasia in a Young Girl. ( 26107677 )
2015
25
Pseudomyocardial infarction caused by adrenocortical adenoma. ( 25708968 )
2015
26
Aggressive spinal glioblastoma in a child with adrenocortical adenoma--Case report and review of literature. ( 26960510 )
2015
27
Epithelioid Angiosarcoma Arising in an Adrenal Cortical Adenoma: A Case Report and Review of the Literature. ( 24771258 )
2014
28
A Mimic of Sarcomatoid Adrenal Cortical Carcinoma: Epithelioid Angiosarcoma Occurring in Adrenal Cortical Adenoma. ( 25246132 )
2014
29
Adrenal cortical adenoma with the maximal diameter greater than 5 cm: can they be differentiated from adrenal cortical carcinoma by CT? ( 25419344 )
2014
30
Occurrence of De Quervain's Thyroiditis after Resolution of Hypercortisolism following Pasireotide Treatment for Cushing's Disease and Surgery for an Adrenocortical Adenoma: Report of Two Cases. ( 24847470 )
2014
31
Myxoid adrenocortical adenoma: magnetic resonance imaging and pathology correlation. ( 24643431 )
2014
32
Ectopic cortisol-producing adrenocortical adenoma in the renal hilum: histopathological features and steroidogenic enzyme profile. ( 25120827 )
2014
33
Ectopic adrenal cortical adenoma in the gastric wall: case report. ( 23429246 )
2013
34
Adrenal cortical adenoma arising from an adrenohepatic union. ( 23686455 )
2013
35
Adrenal cortical adenoma: the fourth component of the Carney triad and an association with subclinical Cushing syndrome. ( 23681078 )
2013
36
A unique case of synchronous functional adrenocortical adenoma and myelolipoma within the ectopic adrenal cortex in a child with Beckwith-Wiedemann syndrome. ( 22309953 )
2012
37
Transumbilical laparo-endoscopic single site surgery for adrenal cortical adenoma inducing primary aldosteronism: initial experience. ( 21943322 )
2011
38
Non-functional adrenocortical adenoma: a unique case of combination with myelolipoma and endothelial cysts. ( 20846791 )
2011
39
Ectopic adrenal cortical adenoma in the spinal region: case report and review of the literature. ( 21046315 )
2010
40
Adrenal pheochromocytoma with contralateral adrenocortical adenoma in a cat. ( 20045835 )
2010
41
Primary aldosteronism due to adrenocortical adenoma with concurrent ileum carcinoid tumor: case report. ( 20972725 )
2010
42
Aldosterone-producing adrenal cortical adenoma with oncocytic change and cytoplasmic eosinophilic globular inclusions. ( 19462261 )
2009
43
Biallelic APC inactivation was responsible for functional adrenocortical adenoma in familial adenomatous polyposis with novel germline mutation of the APC gene: report of a case. ( 19684041 )
2009
44
Coexistence of aldosterone-producing adrenocortical adenoma and pheochromocytoma in an ipsilateral adrenal gland. ( 19023159 )
2009
45
Adrenocortical adenoma with unusual myxoid histological pattern: a case report. ( 19152192 )
2009
46
Adrenocortical adenoma expressing glucocorticoid in an 8-month-old female. ( 19197833 )
2009
47
Endothelial cyst of the adrenal gland associated with adrenocortical adenoma: preoperative images simulate carcinoma. ( 19218775 )
2009
48
Feminizing adrenocortical adenoma in a 5 year-old girl. ( 19344078 )
2009
49
An unusual case of an aldosterone-producing adrenocortical adenoma presenting with rhabdomyolysis. ( 20101896 )
2009
50
Association of an oversized adrenal cortical adenoma with expression of pheochromocytoma-like neurosecretory features. ( 18979561 )
2008
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Variations for Adrenal Cortical Adenoma

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Expression for Adrenal Cortical Adenoma

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Search GEO for disease gene expression data for Adrenal Cortical Adenoma.
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Pathways for Adrenal Cortical Adenoma

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Pathways related to Adrenal Cortical Adenoma according to GeneCards Suite gene sharing:

(show all 13)
# Super pathways Score Top Affiliating Genes
1
Cytochrome P450 - arranged by substrate type 66
Show member pathways
 12.88 CYP11A1 CYP11B1 CYP17A1 CYP21A2 POMC SULT2A1
2
DAG and IP3 signaling 66
Show member pathways
 12.74 CYP11A1 NR5A1 POMC PRKAR1A
3
Aldosterone synthesis and secretion 37
Show member pathways
 12.17 CYP11A1 CYP11B1 CYP17A1 CYP21A2 MC2R NR5A1
4
G alpha (s) signalling events 66
11.82 GIPR MC2R POMC
5
Corticotropin-releasing hormone signaling pathway 1
11.62 CYP11A1 CYP11B1 CYP21A2 POMC SULT2A1
6
Diseases of metabolism 66
Show member pathways
 11.6 CYP11A1 MC2R POMC
7
Cushing syndrome 37
Show member pathways
 11.57 CYP11A1 CYP11B1 CYP17A1 CYP21A2 MC2R NR5A1
8
Metabolism of steroid hormones 66
Show member pathways
 11.5 CYP11A1 CYP11B1 CYP17A1 CYP21A2 POMC
9
Steroid hormone biosynthesis 37
Show member pathways
 11.44 CYP11A1 CYP11B1 CYP17A1 CYP21A2
10
Androstenedione and testosterone biosynthesis and metabolism p.1 22
Show member pathways
 11.34 CYP11B1 CYP17A1 SULT2A1
11
Ovarian steroidogenesis 37
11.2 CYP11A1 CYP17A1
12
Melanocyte Development and Pigmentation 64
11.11 POMC PRKAR1A
13
superpathway of steroid hormone biosynthesis 1
Show member pathways
 10.87 CYP11B1 CYP17A1 CYP21A2
Sources

GO Terms for Adrenal Cortical Adenoma

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Biological processes related to Adrenal Cortical Adenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 oxidation-reduction process GO:0055114 9.71 CYP11A1 CYP11B1 CYP17A1 CYP21A2
2 steroid biosynthetic process GO:0006694 9.56 CYP11A1 CYP11B1 CYP17A1 CYP21A2
3 steroid metabolic process GO:0008202 9.55 CYP11A1 CYP11B1 CYP17A1 CYP21A2 SULT2A1
4 generation of precursor metabolites and energy GO:0006091 9.43 GIPR POMC
5 cellular response to peptide hormone stimulus GO:0071375 9.37 CYP11A1 CYP11B1
6 C21-steroid hormone biosynthetic process GO:0006700 9.32 CYP11A1 CYP11B1
7 sterol metabolic process GO:0016125 9.26 CYP11A1 CYP11B1 CYP17A1 CYP21A2
8 glucocorticoid biosynthetic process GO:0006704 8.92 CYP11A1 CYP11B1 CYP17A1 CYP21A2

Molecular functions related to Adrenal Cortical Adenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 oxidoreductase activity GO:0016491 9.56 CYP11A1 CYP11B1 CYP17A1 CYP21A2
2 heme binding GO:0020037 9.46 CYP11A1 CYP11B1 CYP17A1 CYP21A2
3 iron ion binding GO:0005506 9.26 CYP11A1 CYP11B1 CYP17A1 CYP21A2
4 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen GO:0016705 8.92 CYP11A1 CYP11B1 CYP17A1 CYP21A2
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Sources for Adrenal Cortical Adenoma

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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