MCID: ADR041
MIFTS: 43

Adrenal Cortical Adenoma

Categories: Cancer diseases, Endocrine diseases

Aliases & Classifications for Adrenal Cortical Adenoma

MalaCards integrated aliases for Adrenal Cortical Adenoma:

Name: Adrenal Cortical Adenoma 12 15 71
Adrenocortical Adenoma 12 17
Adenoma Adrenocortical 54

Classifications:



External Ids:

Disease Ontology 12 DOID:0050891
UMLS 71 C0206667

Summaries for Adrenal Cortical Adenoma

Disease Ontology : 12 An adrenal adenoma that is a benign tumor of the adrenal cortex.

MalaCards based summary : Adrenal Cortical Adenoma, also known as adrenocortical adenoma, is related to gynecomastia and acth-independent cushing syndrome. An important gene associated with Adrenal Cortical Adenoma is SYP (Synaptophysin), and among its related pathways/superpathways are Cytochrome P450 - arranged by substrate type and Aldosterone synthesis and secretion. The drugs Etomidate and Anesthetics have been mentioned in the context of this disorder. Affiliated tissues include adrenal cortex, cortex and pituitary, and related phenotypes are Reduced mammosphere formation and behavior/neurological

Wikipedia : 74 Adrenocortical adenoma is commonly described as a benign neoplasm emerging from the cells that comprise... more...

Related Diseases for Adrenal Cortical Adenoma

Diseases related to Adrenal Cortical Adenoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 347)
# Related Disease Score Top Affiliating Genes
1 gynecomastia 30.7 POMC INHA CYP21A2
2 acth-independent cushing syndrome 30.7 PRKAR1A CYP21A2 CYP11B1
3 adrenogenital syndrome 30.5 SYP INHA CYP21A2
4 adrenal adenoma 30.4 SULT2A1 REN PRKAR1A POMC MIR483 MEN1
5 cellular ependymoma 30.4 SYP MEN1
6 hypokalemia 30.4 REN POMC CYP17A1 CYP11B1
7 amenorrhea 30.4 POMC NR5A1 CYP17A1
8 appendix adenocarcinoma 30.4 SYP CHGA
9 granular cell tumor 30.3 SYP MLANA INHA
10 hyperandrogenism 30.3 POMC IGF2 CYP21A2 CYP17A1 CYP11A1
11 pseudohermaphroditism 30.2 POMC NR5A1 CYP21A2 CYP17A1
12 adenoma 30.1 SYP REN PRKAR1A POMC MEN1 MC2R
13 conn's syndrome 30.0 SULT2A1 REN PRKAR1A POMC MEN1 MC2R
14 hyperparathyroidism 30.0 PRKAR1A MEN1 CHGA
15 pheochromocytoma 30.0 SYP REN POMC MEN1 IGF2 CHGA
16 carcinoid syndrome 29.9 SYP MEN1 CHGA
17 paraganglioma 29.9 SYP MEN1 CHGA
18 parathyroid adenoma 29.9 PRKAR1A MEN1 CHGA
19 hemangioma 29.9 SYP MEN1 IGF2 CHGA
20 beckwith-wiedemann syndrome 29.8 PRKAR1A MIR483 MEN1 IGF2
21 primary hyperparathyroidism 29.8 PRKAR1A POMC MEN1 CHGA
22 adrenocortical carcinoma, hereditary 29.7 PRKAR1A MIR483 MC2R IGF2 CYP17A1 CYP11A1
23 acromegaly 29.7 PRKAR1A POMC MEN1 IGF2
24 polycystic ovary syndrome 29.7 SULT2A1 POMC IGF2 CYP21A2 CYP17A1 CYP11A1
25 leydig cell tumor 29.7 SYP NR5A1 INHA CYP21A2 CYP17A1 CYP11A1
26 pituitary adenoma 29.7 PRKAR1A POMC MEN1 CHGA
27 acth-independent macronodular adrenal hyperplasia 29.6 PRKAR1A POMC MIR483 MC2R GIPR CYP11B1
28 lipoid congenital adrenal hyperplasia 29.6 REN POMC NR5A1 MC2R CYP21A2 CYP17A1
29 meningioma, familial 29.6 SYP PRKAR1A POMC MLANA MEN1 IGF2
30 pituitary adenoma, prolactin-secreting 29.6 PRKAR1A POMC NR5A1 MEN1 CHGA
31 gastrointestinal stromal tumor 29.4 SYP MEN1 IGF2 CHGA
32 multiple endocrine neoplasia, type i 29.4 SYP PRKAR1A POMC MIR483 MEN1 CHGA
33 familial glucocorticoid deficiency 29.4 REN POMC NR5A1 MC2R CYP21A2 CYP11B1
34 primary pigmented nodular adrenocortical disease 29.3 SYP PRKAR1A POMC MIR483 MEN1 MC2R
35 hypertension, essential 29.0 REN POMC MIR483 MEN1 CYP17A1 CYP11B1
36 carney complex variant 28.8 PRKAR1A POMC MLANA MIR483 MEN1 MC2R
37 adrenal cortical carcinoma 27.1 SYP REN PRKAR1A POMC NR5A1 MLANA
38 adrenal carcinoma 26.9 SYP REN PRKAR1A POMC NR5A1 MLANA
39 basophil adenoma 10.6 PRKAR1A POMC
40 waterhouse-friderichsen syndrome 10.5 POMC MC2R
41 adrenal gland pheochromocytoma 10.5
42 glomangiosarcoma 10.5 SYP MLANA
43 classic congenital adrenal hyperplasia due to 21-hydroxylase deficiency 10.5 POMC CYP21A2
44 sarcomatoid transitional cell carcinoma 10.5 SYP MLANA
45 alzheimer disease 16 10.5 SULT2A1 POMC
46 hypoaldosteronism 10.5 REN POMC
47 breast neuroendocrine neoplasm 10.5 SYP CHGA
48 primary hepatic neuroendocrine carcinoma 10.5 SYP CHGA
49 small cell carcinoma of the bladder 10.5 SYP CHGA
50 acinar cell cystadenocarcinoma 10.5 SYP CHGA

Graphical network of the top 20 diseases related to Adrenal Cortical Adenoma:



Diseases related to Adrenal Cortical Adenoma

Symptoms & Phenotypes for Adrenal Cortical Adenoma

GenomeRNAi Phenotypes related to Adrenal Cortical Adenoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Reduced mammosphere formation GR00396-S 9.23 CHGA CYP11B1 CYP21A2 GIPR IGF2 MC2R

MGI Mouse Phenotypes related to Adrenal Cortical Adenoma:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.21 CYP11A1 CYP11B1 CYP17A1 CYP21A2 IGF2 MC2R
2 cardiovascular system MP:0005385 10.18 CHGA CYP11A1 CYP11B1 CYP17A1 IGF2 INHA
3 growth/size/body region MP:0005378 10.13 CHGA CYP11A1 CYP11B1 CYP17A1 IGF2 INHA
4 endocrine/exocrine gland MP:0005379 10.11 CHGA CYP11A1 CYP11B1 GIPR IGF2 INHA
5 homeostasis/metabolism MP:0005376 10.1 CHGA CYB5A CYP11A1 CYP11B1 CYP17A1 GIPR
6 mortality/aging MP:0010768 9.8 CHGA CYP11A1 CYP11B1 CYP17A1 CYP21A2 IGF2
7 liver/biliary system MP:0005370 9.7 CYB5A CYP11A1 IGF2 INHA MEN1 POMC
8 reproductive system MP:0005389 9.28 CHGA CYP11A1 CYP17A1 IGF2 INHA MEN1

Drugs & Therapeutics for Adrenal Cortical Adenoma

Drugs for Adrenal Cortical Adenoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 54)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Etomidate Approved Phase 3 33125-97-2 36339 667484
2 Anesthetics Phase 3
3 Fluorodeoxyglucose F18 Phase 3
4 Anesthetics, General Phase 3
5 Hypnotics and Sedatives Phase 3
6 Anesthetics, Intravenous Phase 3
7 glucocorticoids Phase 3
8 Adrenocorticotropic Hormone Phase 3
9 Melanocyte-Stimulating Hormones Phase 3
10 beta-Endorphin Phase 3
11 Gastrointestinal Agents Phase 2
12 Antineoplastic Agents, Hormonal Phase 2
13 Antiemetics Phase 2
14 Anti-Inflammatory Agents Phase 2
15
Dopamine Approved 51-61-6, 62-31-7 681
16
Ethanol Approved 64-17-5 702
17
Angiotensin II Approved, Investigational 4474-91-3, 11128-99-7, 68521-88-0 172198
18
Diltiazem Approved, Investigational 42399-41-7 39186
19
Amlodipine Approved 88150-42-9 2162
20
Indapamide Approved 26807-65-8 3702
21
Bisoprolol Approved 66722-44-9 2405
22
Spironolactone Approved 52-01-7, 1952-01-7 5833
23
Prazosin Approved 19216-56-9 4893
24
Epinephrine Approved, Vet_approved 51-43-4 5816
25
Racepinephrine Approved 329-65-7 838
26
Hydrocortisone Approved, Vet_approved 50-23-7 5754
27
Hydrocortisone acetate Approved, Vet_approved 50-03-3
28
Dexamethasone acetate Approved, Investigational, Vet_approved 1177-87-3
29
Dexamethasone Approved, Investigational, Vet_approved 50-02-2 5743
30
Zinc Approved, Investigational 7440-66-6 32051
31 Insulin, Globin Zinc
32 Hypoglycemic Agents
33 insulin
34 Adrenergic alpha-Agonists
35 Adrenergic beta-Agonists
36 Respiratory System Agents
37 Anti-Asthmatic Agents
38 Adrenergic Agents
39 Vasoconstrictor Agents
40 Adrenergic Agonists
41 Mydriatics
42 Bronchodilator Agents
43 Sympathomimetics
44 Neurotransmitter Agents
45 Angiotensinogen
46 Angiotensin-Converting Enzyme Inhibitors
47 Angiotensin Receptor Antagonists
48 Antihypertensive Agents
49 Giapreza
50 Epinephryl borate

Interventional clinical trials:

(show all 21)
# Name Status NCT ID Phase Drugs
1 Combined 18F-Fluorodeoxyglucose (FDG) Positron Emission Tomography (PET) and 123I-Iodometomidate (123I-IMTO) Imaging for Adrenal Neoplasia Unknown status NCT02010957 Phase 3
2 Glucocorticoid Receptor Antagonism in the Treatment of Hypercortisolism in Patients With Cortisol-Secreting Adrenal Adenomas or Hyperplasia: A Phase 3, Randomized, Double-Blind, Placebo-Controlled Study of the Efficacy and Safety of Relacorilant Recruiting NCT04308590 Phase 3 relacorilant
3 A Multicenter Medical Safety Follow-up Study for Patients With Partial Onset Seizures Who Received More Than 28 Days of Total Exposure to BGG492 in Studies CBGG492A2207 and/or CBGG492A2212 Completed NCT02150213 Phase 2 BGG492
4 A Phase II, Open-label, Dose Titration, Multi-center Study to Assess the Safety/Tolerability and Efficacy of Osilodrostat in Patients With All Types of Endogenous Cushing's Syndrome Except Cushing's Disease Completed NCT02468193 Phase 2 Osilodrostat
5 Laparoscopic Adrenalectomy Versus Radiofrequency Ablation for Aldosterone-producing Adenoma: a Prospective Randomized Controlled Trial Unknown status NCT02030587
6 Expression of D2-Like Dopamine Receptor of Human Aldosterone-Producing Adenoma and Its Role in Regulation of Aldosterone Secretion and Cell Proliferation Unknown status NCT00173446
7 Evaluation of the Diagnostic Utility of Serum Dexamethasone Measurements in the Overnight 1mg Dexamethasone Suppression Test in Patients Investigated for Cushing's Syndrome and Incidentalomas Unknown status NCT01504555
8 Radiofrequency Ablation for Aldosterone-producting Adenoma in Patients With Primary Aldosteronism: Evaluation of the Blood Pressure Control and of Its Safety. Completed NCT02756754
9 Prevention of Conversion in Posterior Retroperitoneal Adrenalectomy by Measuring Preoperative Anatomical Conditions on Cross-sectional Imaging (CT or MRI) Completed NCT04071561
10 Is There Anything New in the Field of Large Adrenal Tumors ? Completed NCT03830593
11 Cardiovascular Risk in Patients With Non-Functional Adrenal Incidentaloma: Myth or Reality? Completed NCT00768365
12 Complex Cystic Benign Adrenal Incidentalomas Mimicking Non-adenomatous Masses; Rare Pathologies: Clinical Features and Outcomes. Case Series With Short Review of Literature. Completed NCT03739918
13 Effect of Chronic Catecholamine Overproduction on Brown Adipose Tissue Recruiting NCT01949714
14 Long-term Effects of Adrenalectomy on Metabolic Syndrome, Glucose Metabolism, Lipid Metabolism, and Bone Metabolism in Subclinical Cushing's Syndrome of Adrenal Incidentaloma Recruiting NCT01382420
15 Feasibility Study of RadioFrequency Endoscopic ABlation, With ULtrasound Guidance, as a Non-surgical, Adrenal Sparing Treatment for Aldosterone-producing Adenomas Recruiting NCT03405025
16 Impact of Adrenal IncidenTalomas and Possible Autonomous Cortisol Secretion on Cardiovascular and Metabolic Alterations (ITACA Study) Recruiting NCT04127552
17 Structured Evaluation of adRENal Tumors Discovered Incidentally - Prospectively Investigating the Testing Yield Recruiting NCT02324647
18 Surgery of Subclinical Cortisol Secreting Adrenal Incidentalomas Recruiting NCT02364089 Standardized medical treatment of hypertension by SAHR
19 Morbidity and Mortality in Patients With Adrenal Incidentalomas With and Without Autonomous Cortisol Secretion Active, not recruiting NCT03919734
20 A Prospective Cohort Study for Patients With Adrenal Diseases Enrolling by invitation NCT03474237
21 Comparison of Imaging Quality Between Spectral Photon Counting Computed Tomography (SPCCT) and Dual Energy Computed Tomography (DECT) Not yet recruiting NCT04328181

Search NIH Clinical Center for Adrenal Cortical Adenoma

Genetic Tests for Adrenal Cortical Adenoma

Anatomical Context for Adrenal Cortical Adenoma

MalaCards organs/tissues related to Adrenal Cortical Adenoma:

40
Adrenal Cortex, Cortex, Pituitary, Adrenal Gland, Testes, Thyroid, Bone

Publications for Adrenal Cortical Adenoma

Articles related to Adrenal Cortical Adenoma:

(show top 50) (show all 952)
# Title Authors PMID Year
1
Biallelic APC inactivation was responsible for functional adrenocortical adenoma in familial adenomatous polyposis with novel germline mutation of the APC gene: report of a case. 54 61
19684041 2009
2
Detection of somatic beta-catenin mutations in primary pigmented nodular adrenocortical disease (PPNAD). 54 61
18419788 2008
3
The role of immunohistochemistry in histopathological diagnostics of clinically "silent" incidentally detected adrenal masses. 54 61
18393131 2008
4
Unique association of non-functioning pheochromocytoma, ganglioneuroma, adrenal cortical adenoma, hepatic and vertebral hemangiomas in a patient with a new intronic variant in the VHL gene. 61 54
16483185 2005
5
Significance of inhibin in reproductive pathophysiology and current clinical applications. 54 61
15970011 2005
6
Myxoid adrenocortical adenoma with a pseudoglandular pattern. 61 54
15235911 2004
7
Analysis of somatic APC mutations in rare extracolonic tumors of patients with familial adenomatous polyposis coli. 61 54
15287021 2004
8
Primary hyperparathyroidism associatiated with aldosterone-producing adrenocortical adenoma and breast cancer: relation to MEN1 gene. 54 61
15168774 2004
9
[The expression of A103 and inhibin alpha in adrenocortical adenoma by high-throughput tissue microarray techniques]. 61 54
12910679 2003
10
Massive adrenocortical adenoma following long-term treatment of 21-hydroxylase deficiency. 54 61
11832743 2002
11
Immunoexpression of inhibin alpha-subunit in adrenal neoplasms. 54 61
11556749 2001
12
Expression of adrenocorticotropin receptor gene in adrenocortical adenomas from patients with Cushing syndrome: possible contribution for the autonomous production of cortisol. 54 61
11420487 2001
13
Food-dependent androgen and cortisol secretion by a gastric inhibitory polypeptide-receptor expressive adrenocortical adenoma leading to hirsutism and subclinical Cushing's syndrome: in vivo and in vitro studies. 54 61
11158012 2001
14
Virilizing adrenocortical adenoma: in vitro steroidogenesis, immunohistochemical studies of steroidogenic enzymes, and gene expression of corticotropin receptor. 61 54
10216530 1999
15
Gene expression and roles of angiotensin II type 1 and type 2 receptors in human adrenals. 61 54
9761377 1998
16
[Aberrant expression of the GIP (Gastric Inhibitory Polypeptide) receptor in an adrenal cortical adenoma responsible for a case of food-dependent Cushing's syndrome]. 54 61
10333644 1998
17
Aldosterone-producing adrenocortical adenoma complicated by chronic renal failure. Case report and review of the literature. 61 54
9845833 1998
18
Evaluation of plasma aldosterone to plasma renin activity ratio in patients with primary aldosteronism. 61 54
9249232 1997
19
Oestrogen producing adrenocortical adenoma: clinical, biochemical and immunohistochemical studies. 61 54
8977764 1996
20
Immunolocalization of dehydroepiandrosterone sulfotransferase in normal and pathologic human adrenal gland. 61 54
8751327 1995
21
Expression of a high molecular weight form of insulin-like growth factor II in a Beckwith-Wiedemann syndrome associated adrenocortical adenoma. 61 54
7621447 1995
22
In-vitro evidence for the regulation of 17,20-lyase activity by cytochrome b5 in adrenocortical adenomas from patients with Cushing's syndrome. 61 54
8137519 1994
23
Mechanism of abnormal production of adrenal androgens in patients with adrenocortical adenomas and carcinomas. 61 54
8288710 1994
24
Disordered expression of adrenal steroidogenic P450 mRNAs in incidentally discovered nonfunctioning adrenal adenoma. 61 54
1535042 1992
25
Decreased levels of steroid 21-hydroxylase [P450(c21)] and its mRNA in an adrenocortical adenoma associated with 21-hydroxylase deficiency. 54 61
2101789 1990
26
Endocrine activity of the "silent" adrenocortical adenoma is uncovered by response to corticotropin-releasing hormone. 61 54
2165544 1990
27
Stemness regulation of the adrenal mixed corticomedullary tumorigenesis-a case-control study. 61
32438306 2020
28
Cardiac Myxoma Caused by Fumarate Hydratase Gene Deletion in Patient With Cortisol-Secreting Adrenocortical Adenoma. 61
32249909 2020
29
Retrospective comparison of three minimally invasive approaches for adrenal tumors: perioperative outcomes of transperitoneal laparoscopic, retroperitoneal laparoscopic and robot-assisted laparoscopic adrenalectomy. 61
32517679 2020
30
Stathmin 1 is highly expressed and associated with survival outcome in malignant adrenocortical tumours. 61
31441020 2020
31
Hemodynamics of primary aldosteronism associated with adrenocortical adenoma: Insights from bioimpedance cardiography measurements. 61
32533871 2020
32
Pregnancy-induced Cushing's syndrome with an adrenocortical adenoma overexpressing LH/hCG receptors: a case report. 61
32393232 2020
33
Immunohistochemical Analysis of the Metabolic Phenotype of Adrenal Cortical Carcinoma. 61
32367334 2020
34
Adrenal cortical adenoma: current update, imaging features, atypical findings, and mimics. 61
31529204 2020
35
Ectopic Cortisol-producing Adrenocortical Adenoma Detected by 131I-6 (-Iodomethyl-norcholesterol Scintigraphy. 61
32238722 2020
36
An Activating Variant in CTNNB1 is Associated with a Sclerosing Bone Dysplasia and Adrenocortical Neoplasia. 61
31970420 2020
37
[A Case of 18FDG PET/CT-Positive Adrenal Adenoma Suspected of Being Adrenal Metastasis of Synchronous Triple Cancer]. 61
32316702 2020
38
An Incidental Diagnosis of Microscopic Renal Angiomyolipoma Completely Excised on Renal Biopsy: A Case Report. 61
32172274 2020
39
Endoplasmic Reticulum Chaperone Calmegin Is Upregulated in Aldosterone-Producing Adenoma and Associates With Aldosterone Production. 61
31865789 2020
40
Adrenalectomy for non-neuroblastic pathology in children. 61
31691026 2020
41
Primary aldosteronism concurrent with subclinical Cushing's syndrome: a case report and review of the literature. 61
32075693 2020
42
Unique Sex Steroid Profiles in Estrogen-Producing Adrenocortical Adenoma Associated With Bilateral Hyperaldosteronism. 61
32099947 2020
43
A rare presentation of adrenal adenoma in infancy: isolated Cushing`s syndrome. 61
32253882 2020
44
Adrenocortical tumors have a distinct, long, non-coding RNA expression profile and LINC00271 is downregulated in malignancy. 61
31522749 2020
45
Primary Aldosteronism Associated with Multiple Adrenocortical Micronodules in a Patient with Renal Cell Carcinoma. 61
32158565 2020
46
Pseudoglandular myxoid adrenocortical adenoma with positive epithelial markers: a case report and review of the literature. 61
32509084 2020
47
Adrenal Cortical Adenoma in the Spinal Canal: A Case Report and Review of the Literature. 61
31127594 2020
48
Metallothionein protein and minichromosome maintenance protein-2 expression in adrenocortical tumors. 61
31703800 2019
49
IGF2 role in adrenocortical carcinoma biology. 61
31378849 2019
50
Expression of FSCN1 and FOXM1 are associated with poor prognosis of adrenocortical carcinoma patients. 61
31783819 2019

Variations for Adrenal Cortical Adenoma

Expression for Adrenal Cortical Adenoma

Search GEO for disease gene expression data for Adrenal Cortical Adenoma.

Pathways for Adrenal Cortical Adenoma

Pathways related to Adrenal Cortical Adenoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.91 SULT2A1 POMC CYP21A2 CYP17A1 CYP11B1 CYP11A1
2
Show member pathways
12 POMC NR5A1 MEN1 MC2R CYP21A2 CYP17A1
3
Show member pathways
11.58 POMC MC2R CYP11A1
4 11.52 SULT2A1 POMC CYP21A2 CYP11B1 CYP11A1
5
Show member pathways
11.38 CYP21A2 CYP17A1 CYP11B1 CYP11A1
6
Show member pathways
11.31 SULT2A1 CYP17A1 CYP11B1
7
Show member pathways
11.3 POMC CYP21A2 CYP17A1 CYP11B1 CYP11A1
8
Show member pathways
10.84 CYP21A2 CYP17A1 CYP11B1

GO Terms for Adrenal Cortical Adenoma

Cellular components related to Adrenal Cortical Adenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 organelle membrane GO:0031090 8.8 CYP21A2 CYP17A1 CYB5A

Biological processes related to Adrenal Cortical Adenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 steroid metabolic process GO:0008202 9.67 SULT2A1 CYP21A2 CYP17A1 CYP11A1
2 male gonad development GO:0008584 9.63 REN NR5A1 INHA
3 sterol metabolic process GO:0016125 9.5 CYP21A2 CYP11B1 CYP11A1
4 steroid biosynthetic process GO:0006694 9.46 CYP21A2 CYP17A1 CYP11B1 CYP11A1
5 C21-steroid hormone biosynthetic process GO:0006700 9.43 CYP11B1 CYP11A1
6 cellular response to peptide hormone stimulus GO:0071375 9.43 MEN1 CYP11B1 CYP11A1
7 cortisol metabolic process GO:0034650 9.4 CYP11B1 CYP11A1
8 regulation of blood pressure GO:0008217 9.26 REN POMC CYP11B1 CHGA
9 glucocorticoid biosynthetic process GO:0006704 8.92 CYP21A2 CYP17A1 CYP11B1 CYP11A1

Molecular functions related to Adrenal Cortical Adenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 iron ion binding GO:0005506 9.56 CYP21A2 CYP17A1 CYP11B1 CYP11A1
2 monooxygenase activity GO:0004497 9.46 CYP21A2 CYP17A1 CYP11B1 CYP11A1
3 insulin-like growth factor receptor binding GO:0005159 9.32 REN IGF2
4 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen GO:0016705 9.26 CYP21A2 CYP17A1 CYP11B1 CYP11A1
5 heme binding GO:0020037 9.02 CYP21A2 CYP17A1 CYP11B1 CYP11A1 CYB5A

Sources for Adrenal Cortical Adenoma

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