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MCID: ADR010
MIFTS: 32

Adrenal Cortical Hypofunction

Categories: Endocrine diseases
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Aliases & Classifications for Adrenal Cortical Hypofunction

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MalaCards integrated aliases for Adrenal Cortical Hypofunction:

Name: Adrenal Cortical Hypofunction 11 14 71
Adrenal Cortical Insufficiency 11
Corticoadrenal Insufficiency 11

Classifications:

MalaCards categories:
Anatomical: Endocrine diseases
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Disease Ontology 11 DOID:10493
ICD9CM 34 255.4
NCIt 49 C26691
SNOMED-CT 68 68588005
UMLS 71 C0405580
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Summaries for Adrenal Cortical Hypofunction

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MalaCards based summary: Adrenal Cortical Hypofunction, also known as adrenal cortical insufficiency, is related to premature ovarian failure 7 and achalasia-addisonianism-alacrima syndrome. An important gene associated with Adrenal Cortical Hypofunction is NR0B1 (Nuclear Receptor Subfamily 0 Group B Member 1), and among its related pathways/superpathways are Metabolism of steroid hormones and Corticotropin-releasing hormone signaling pathway. Affiliated tissues include adrenal cortex, cortex and adrenal gland, and related phenotypes are Reduced mammosphere formation and homeostasis/metabolism
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Related Diseases for Adrenal Cortical Hypofunction

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Diseases related to Adrenal Cortical Hypofunction via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 207)
# Related Disease Score Top Affiliating Genes
1 premature ovarian failure 7 32.5 POMC NR5A1 CRH
2 achalasia-addisonianism-alacrima syndrome 32.3 POMC NR0B1 MC2R CYP11A1
3 adrenal hypoplasia, congenital 32.0 POMC NR5A1 NR0B1 MC2R CYP21A2 CYP11A1
4 hypoadrenocorticism, familial 30.9 TPO TG REN PTPN22 POMC NR5A1
5 pituitary-dependent cushing's disease 30.4 POMC MC2R CRH
6 hypopituitarism 30.2 POMC INS CRH
7 conn's syndrome 29.4 REN POMC NR5A1 NR0B1 MC2R INS
8 mediastinal lipomatosis 10.4 POMC CRH
9 ectopic cushing syndrome 10.4 POMC CRH
10 mechanical strabismus 10.4 TPO TG
11 post-vaccinal encephalitis 10.4 POMC CCR6
12 epithelial malignant thymoma 10.4 TG AIRE
13 hypoaldosteronism 10.4 REN POMC
14 iodine hypothyroidism 10.4 TPO TG
15 premenstrual tension 10.4 REN POMC
16 cutaneous candidiasis 10.4 NUDT10 CCR6 AIRE
17 suppurative thyroiditis 10.4 TPO TG
18 nonencapsulated sclerosing carcinoma 10.4 TPO TG
19 acute thyroiditis 10.4 TPO TG
20 endocrine exophthalmos 10.4 TPO TG
21 autoimmune polyendocrine syndrome type 1 10.4 NUDT10 CCR6 AIRE
22 dendritic cell thymoma 10.4 TG AIRE
23 goiter, multinodular 1, with or without sertoli-leydig cell tumors 10.3 TPO TG
24 nail disease 10.3 NUDT10 CCR6 AIRE
25 acidophil adenoma 10.3 POMC INS
26 somatization disorder 10.3 POMC CRH
27 cavernous sinus thrombosis 10.3 POMC INS
28 45,x/46,xy mixed gonadal dysgenesis 10.3 NR5A1 NR0B1
29 jejunoileitis 10.3 TOR1A CCR6
30 thyrotoxic exophthalmos 10.3 TPO TG
31 scleredema adultorum 10.3 POMC INS
32 factitious disorder 10.3 POMC INS
33 orbital plasma cell granuloma 10.3 TPO TG
34 acute adrenal insufficiency 10.3 POMC CYP21A2 CYP11A1
35 postsurgical hypothyroidism 10.3 TPO TG
36 chronic orbital inflammation 10.3 TPO TG
37 toxic diffuse goiter 10.3 TPO TG
38 juvenile dermatitis herpetiformis 10.3 TNFRSF25 HLA-DQA1
39 postpartum depression 10.3 TPO POMC CRH
40 ovarian serous adenofibroma 10.3 TG POMC
41 thyroid crisis 10.3 TPO TG POMC
42 polycystic kidney disease 4 10.3 TPO REN
43 gangliocytoma 10.3 POMC CRH
44 glycerol kinase deficiency 10.3 POMC NR5A1 NR0B1
45 thyroid dyshormonogenesis 2a 10.3 TPO TG POMC
46 thyroid lymphoma 10.3 TPO TG
47 mixed gonadal dysgenesis 10.3 NR5A1 NR0B1 CYP21A2
48 hypothyroidism, congenital, nongoitrous, 4 10.3 TPO TG POMC
49 autoimmune polyendocrine syndrome, type i, with or without reversible metaphyseal dysplasia 10.3 CYP21A2 CYP11A1 AIRE
50 subacute lymphocytic thyroiditis 10.3 TPO TG

Graphical network of the top 20 diseases related to Adrenal Cortical Hypofunction:



Diseases related to Adrenal Cortical Hypofunction
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Symptoms & Phenotypes for Adrenal Cortical Hypofunction

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GenomeRNAi Phenotypes related to Adrenal Cortical Hypofunction according to GeneCards Suite gene sharing:

25
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 no effect GR00402-S-1 10.18 ABCD1 AIRE CCR6 CRH CYP11A1 CYP21A2
2 no effect GR00402-S-2 10.18 AIRE CCR6 CRH CYP11A1 CYP21A2 HLA-DQA1
3 Reduced mammosphere formation GR00396-S 9.56 ABCD1 CCR6 CYP21A2 HLA-DQA1 MC2R NR0B1

MGI Mouse Phenotypes related to Adrenal Cortical Hypofunction:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.31 ABCD1 AIRE CCR6 CRH CYP11A1 INS
2 nervous system MP:0003631 10.21 ABCD1 AIRE CCR6 CRH CYP11A1 INS
3 endocrine/exocrine gland MP:0005379 10.2 ABCD1 AIRE CRH CYP11A1 HLA-DQA1 INS
4 growth/size/body region MP:0005378 10.18 AIRE CRH CYP11A1 CYP21A2 INS MC2R
5 normal MP:0002873 10.11 ABCD1 AIRE CCR6 CRH CYP11A1 INS
6 behavior/neurological MP:0005386 10.07 ABCD1 AIRE CRH CYP11A1 CYP21A2 INS
7 immune system MP:0005387 10.06 ABCD1 AIRE CCR6 CRH CYP11A1 CYP21A2
8 reproductive system MP:0005389 9.65 ABCD1 AIRE CYP11A1 INS NR0B1 NR5A1
9 hematopoietic system MP:0005397 9.53 ABCD1 AIRE CCR6 CRH CYP11A1 CYP21A2
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Drugs & Therapeutics for Adrenal Cortical Hypofunction

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Search Clinical Trials, NIH Clinical Center for Adrenal Cortical Hypofunction

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Genetic Tests for Adrenal Cortical Hypofunction

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Anatomical Context for Adrenal Cortical Hypofunction

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Organs/tissues related to Adrenal Cortical Hypofunction:

MalaCards : Adrenal Cortex, Cortex, Adrenal Gland, Pituitary, Lung, Thyroid
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Publications for Adrenal Cortical Hypofunction

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Articles related to Adrenal Cortical Hypofunction:

(show top 50) (show all 115)
# Title Authors PMID Year
1
Adverse Drug Reactions of Intranasal Corticosteroids in the Netherlands: An Analysis from the Netherlands Pharmacovigilance Center. 62
35661117 2022
2
Adrenal insufficiency of patients with graft versus host disease treated with extracorporeal photopheresis. 62
31188658 2019
3
A human mode of intestinal type gastric carcinoma. 62
30696587 2019
4
A Novel GMPPA Mutation in Two Adult Sisters with Achalasia, Alacrima, Short Stature, Dysmorphism, and Intellectual Disability. 62
29593478 2018
5
Lysosomal Acid Lipase Deficiency 62
26225414 2015
6
Adrenal cortical insufficiency--a life threatening illness with multiple etiologies. 62
24529304 2013
7
Lower Serum Androstenedione Levels in Pre-Rheumatoid Arthritis versus Normal Control Women: Correlations with Lower Serum Cortisol Levels. 62
23762532 2013
8
Transsphenoidal surgery for Cushing disease: experience with 136 patients. 62
21772221 2012
9
Fatal gastrointestinal hemorrhage in a paraplegic man with undiagnosed AA (secondary) amyloidosis. 62
22014073 2011
10
Pituitary FDG uptake in a patient of lung cancer with bilateral adrenal metastases causing adrenal cortical insufficiency. 62
21716036 2011
11
Presentation of primary adrenal insufficiency in childhood. 62
21470994 2011
12
[Congenital adrenal hyperplasia complicated by testicular adrenal rest tumors: one-case clinical analysis]. 62
21171267 2010
13
[Clinical features of 9 patients with X-linked adrenal hypoplasia congenita caused by DAX1/NR0B1 gene mutations]. 62
21029627 2010
14
Familial risks for hospitalization with endocrine diseases. 62
18827002 2008
15
Blood eosinophilia, corticoadrenal insufficiency and eosinophilic cystitis. 62
18362497 2008
16
[Primary adrenal cortical insufficiency (Addison's disease)]. 62
17109274 2006
17
[Laparoscopic surgery for benign adrenal tumor: a report of 10 cases]. 62
15642205 2005
18
[Werner's syndrome and endocrine disorders]. 62
12910063 2003
19
Cholesterol and development: the RSH ("Smith-Lemli-Opitz") syndrome and related conditions. 62
11942534 2002
20
Adrenopause: an imbalance between dehydroepiandrosterone (DHEA) and cortisol secretion. 62
12508910 2002
21
[Polyglandular autoimmune syndrome type II: epidemiology and forms of manifestation]. 62
10629665 1999
22
Rapid decline of fertility in a case of adrenoleukodystrophy. 62
9806270 1998
23
[Assessment of the hypothalamic-hypophyseal-adrenal axis in patients with chronic obstructive lung disease. Comparison of inhalant with systemic glucocorticoid therapy]. 62
9162622 1997
24
Assessment of adrenal function in women heterozygous for adrenoleukodystrophy. 62
9062496 1997
25
Mineralocorticoid insufficiency due to suramin therapy. 62
8941013 1996
26
[Clinical manifestation of adrenal cortex insufficiency during thyroid hormone substitution]. 62
8681734 1996
27
Early detection of neonatal adrenal hemorrhage by ultrasonography. 62
8935412 1996
28
[Diagnosis of adrenal cortex insufficiency in steroid-dependent bronchial asthma--the CRH test in comparison with diurnal cortisol profile in serum and cortisol in 24-hour urine]. 62
7824500 1994
29
Acute onset of X-linked adrenoleukodystrophy mimicking encephalitis. 62
7943611 1994
30
Addison's disease secondary to prostatic carcinoma. A case report. 62
2284701 1990
31
Contrasting effects of nitrofurans on plasma corticosterone in chickens following administration as a bolus or diet additive. 62
2231866 1990
32
[Adrenoleukodystrophy and adrenomyeloneuropathy--clinical spectrum, pathobiochemical aspects, diagnosis and therapy]. 62
2559009 1989
33
Hypoglycemia secondary to endocrine deficiencies. 62
2537192 1989
34
Endocrine complications of the acquired immunodeficiency syndrome. 62
2644904 1989
35
[Hypotension in pregnancy, a sequela of adrenal cortex insufficiency?]. 62
3325331 1987
36
Repeatedly relapsing disseminated histoplasmosis: clinical observations during long-term follow-up. 62
3598232 1987
37
1-Thioglycerol: inhibitor of glycerol kinase activity in vitro and in situ. 62
3022087 1986
38
Identification of the inflammatory cells in the central nervous system of patients with adrenoleukodystrophy. 62
3909937 1985
39
Adrenal dysfunction in glycerol kinase deficiency. 62
2988520 1985
40
Adrenoleukodystrophy: survey of 303 cases: biochemistry, diagnosis, and therapy. 62
6524872 1984
41
[Corticoadrenal insufficiency (Addison's disease)]. 62
6495444 1984
42
Zinc metabolism in adrenal cortical insufficiency: effects of carbohydrate-active steroids. 62
6727650 1984
43
Adrenal cysts in the newborn. 62
6854747 1983
44
Functional significance of idiopathic adrenal calcification in the adult. 62
6247105 1980
45
[Vitamin C content and vascular permeability in chronic adrenal cortical insufficiency]. 62
494624 1979
46
Reversible adrenocorticol insufficiency in fulminant meningococcemia. 62
110279 1979
47
[Adrenoleukodystrophy (melanodermic leukodystrophy). Report of an anatomo-clinical case]. 62
496705 1979
48
Adrenal cortical insufficiency in young chickens exposed to a high ambient temperature. 62
751049 1978
49
Canine immune complex diseases. 62
136591 1976
50
Modification of corticosterone and glucose responses by sympatholytic agents in young chickens during acute heat exposure. 62
825847 1976
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Variations for Adrenal Cortical Hypofunction

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Expression for Adrenal Cortical Hypofunction

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Search GEO for disease gene expression data for Adrenal Cortical Hypofunction.
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Pathways for Adrenal Cortical Hypofunction

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Pathways related to Adrenal Cortical Hypofunction according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Metabolism of steroid hormones 66
Show member pathways
 11.32 POMC CYP21A2 CYP11A1
2
Corticotropin-releasing hormone signaling pathway 74
10.88 POMC CYP21A2 CYP11A1 CRH
3
Genes associated with the development of rheumatoid arthritis 74
10.51 PTPN22 CCR6
4
Glucocorticoid Pathway (HPA Axis), Pharmacodynamics 60
9.8 POMC CRH
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GO Terms for Adrenal Cortical Hypofunction

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Biological processes related to Adrenal Cortical Hypofunction according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 luteinization GO:0001553 9.62 PTPRN NR5A1
2 Sertoli cell differentiation GO:0060008 9.56 NR5A1 NR0B1
3 adrenal gland development GO:0030325 9.43 NR5A1 NR0B1 CRH
4 sex determination GO:0007530 9.33 NR5A1 NR0B1
5 glucocorticoid biosynthetic process GO:0006704 9.1 CYP21A2 CYP11A1 CRH

Molecular functions related to Adrenal Cortical Hypofunction according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 9.23 TG POMC INS CRH
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Sources for Adrenal Cortical Hypofunction

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2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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