MCID: ADR010
MIFTS: 31

Adrenal Cortical Hypofunction

Categories: Endocrine diseases

Aliases & Classifications for Adrenal Cortical Hypofunction

MalaCards integrated aliases for Adrenal Cortical Hypofunction:

Name: Adrenal Cortical Hypofunction 12 15 70
Adrenal Cortical Insufficiency 12
Corticoadrenal Insufficiency 12

Classifications:



External Ids:

Disease Ontology 12 DOID:10493
ICD9CM 34 255.4
NCIt 50 C26691
SNOMED-CT 67 68588005
UMLS 70 C0405580

Summaries for Adrenal Cortical Hypofunction

MalaCards based summary : Adrenal Cortical Hypofunction, also known as adrenal cortical insufficiency, is related to premature ovarian failure 7 and achalasia-addisonianism-alacrima syndrome. An important gene associated with Adrenal Cortical Hypofunction is CCR6 (C-C Motif Chemokine Receptor 6), and among its related pathways/superpathways are Aldosterone synthesis and secretion and Diseases of metabolism. Affiliated tissues include cortex and adrenal cortex, and related phenotypes are Decreased viability and Decreased viability

Related Diseases for Adrenal Cortical Hypofunction

Diseases related to Adrenal Cortical Hypofunction via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 181)
# Related Disease Score Top Affiliating Genes
1 premature ovarian failure 7 32.5 NR5A1 ABCD1
2 achalasia-addisonianism-alacrima syndrome 32.4 POMC NR0B1 MC2R
3 adrenal hypoplasia, congenital 32.1 POMC NR5A1 NR0B1 MC2R
4 hypoadrenocorticism, familial 30.6 TPO TG REN PTPN22 POMC NR5A1
5 hypopituitarism 30.2 POMC INS CRH
6 adie pupil 10.4 TOR1A TNFRSF25
7 cytochrome p450 oxidoreductase deficiency 10.4 POMC CYP21A2
8 type 1 diabetes mellitus 18 10.4 TNFRSF25 PTPN22
9 ectopic cushing syndrome 10.4 POMC CRH
10 hypoaldosteronism 10.4 REN POMC
11 type 1 diabetes mellitus 8 10.4 PTPN22 CCR6
12 mechanical strabismus 10.4 TPO TG
13 nonsyndromic disorders of testicular development 10.4 NR5A1 NR0B1
14 premenstrual tension 10.4 REN POMC
15 somatization disorder 10.4 POMC CRH
16 epithelial malignant thymoma 10.4 TG AIRE
17 iodine hypothyroidism 10.4 TPO TG
18 autoimmune hepatitis type 2 10.4 CYP21A2 CYP11A1
19 dendritic cell thymoma 10.4 TG AIRE
20 fasting hypoglycemia 10.4 POMC CRH
21 selective igg deficiency disease 10.4 TOR1A TNFRSF25
22 immunodeficiency 31c 10.4 TNFRSF25 PTPN22 AIRE
23 nonencapsulated sclerosing carcinoma 10.4 TPO TG
24 latent autoimmune diabetes in adults 10.4 PTPN22 INS
25 precocious puberty, male-limited 10.4 POMC NR0B1 CYP21A2
26 acute thyroiditis 10.4 TPO TG
27 toxic diffuse goiter 10.4 TPO TG
28 aspirin allergy 10.4 TPO TG
29 conversion disorder 10.4 TOR1A CRH
30 postsurgical hypothyroidism 10.4 TPO TG
31 acidophil adenoma 10.4 POMC INS
32 immunoglobulin alpha deficiency 10.4 TOR1A TNFRSF25 CCR6
33 bullous skin disease 10.3 TOR1A TNFRSF25 CCR6
34 nail disorder, nonsyndromic congenital, 1 10.3 TG CCR6 AIRE
35 polyendocrinopathy 10.3 CYP11A1 AIRE
36 esophageal candidiasis 10.3 CCR6 AIRE
37 classic congenital adrenal hyperplasia due to 21-hydroxylase deficiency 10.3 POMC CYP21A2
38 goiter, multinodular 1, with or without sertoli-leydig cell tumors 10.3 TPO TG
39 inappropriate adh syndrome 10.3 REN POMC CRH
40 ovarian serous adenofibroma 10.3 TG POMC
41 pituitary-dependent cushing's disease 10.3 POMC CRH
42 cutaneous candidiasis 10.3 CCR6 AIRE
43 scleredema adultorum 10.3 POMC INS
44 subacute lymphocytic thyroiditis 10.3 TPO TG
45 postpartum depression 10.3 TPO POMC CRH
46 thyroid crisis 10.3 TPO TG POMC
47 isthmus cancer 10.3 TG PTPRN
48 wissler-fanconi syndrome 10.3 PTPRN POMC AIRE
49 myxedema 10.3 TPO TG POMC
50 persistent mullerian duct syndrome 10.3 NR5A1 NR0B1 CYP21A2

Graphical network of the top 20 diseases related to Adrenal Cortical Hypofunction:



Diseases related to Adrenal Cortical Hypofunction

Symptoms & Phenotypes for Adrenal Cortical Hypofunction

GenomeRNAi Phenotypes related to Adrenal Cortical Hypofunction according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00173-A 9.77 PTPRN
2 Decreased viability GR00240-S-1 9.77 NUDT10 TG
3 Decreased viability GR00249-S 9.77 MC2R NR0B1 NUDT10 PTPRN
4 Decreased viability GR00386-A-1 9.77 NR5A1 POMC
5 Decreased viability GR00402-S-2 9.77 ABCD1 MC2R NR5A1 TNFRSF25
6 Reduced mammosphere formation GR00396-S 9.17 ABCD1 CCR6 CYP21A2 MC2R NR0B1 POMC

MGI Mouse Phenotypes related to Adrenal Cortical Hypofunction:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.3 ABCD1 AIRE CCR6 CRH CYP11A1 CYP21A2
2 endocrine/exocrine gland MP:0005379 10.28 ABCD1 AIRE CRH CYP11A1 INS MC2R
3 behavior/neurological MP:0005386 10.27 ABCD1 AIRE CRH CYP11A1 CYP21A2 INS
4 homeostasis/metabolism MP:0005376 10.25 ABCD1 AIRE CCR6 CRH CYP11A1 INS
5 growth/size/body region MP:0005378 10.22 AIRE CRH CYP11A1 CYP21A2 INS MC2R
6 immune system MP:0005387 10.19 ABCD1 AIRE CCR6 CRH CYP11A1 CYP21A2
7 mortality/aging MP:0010768 9.97 ABCD1 AIRE CYP11A1 CYP21A2 INS MC2R
8 nervous system MP:0003631 9.73 ABCD1 AIRE CCR6 CRH CYP11A1 INS
9 normal MP:0002873 9.28 ABCD1 AIRE CCR6 CRH CYP11A1 INS

Drugs & Therapeutics for Adrenal Cortical Hypofunction

Search Clinical Trials , NIH Clinical Center for Adrenal Cortical Hypofunction

Genetic Tests for Adrenal Cortical Hypofunction

Anatomical Context for Adrenal Cortical Hypofunction

MalaCards organs/tissues related to Adrenal Cortical Hypofunction:

40
Cortex, Adrenal Cortex

Publications for Adrenal Cortical Hypofunction

Articles related to Adrenal Cortical Hypofunction:

(show all 24)
# Title Authors PMID Year
1
A human mode of intestinal type gastric carcinoma. 61
30696587 2019
2
Presentation of primary adrenal insufficiency in childhood. 61
21470994 2011
3
[Congenital adrenal hyperplasia complicated by testicular adrenal rest tumors: one-case clinical analysis]. 61
21171267 2010
4
[Clinical features of 9 patients with X-linked adrenal hypoplasia congenita caused by DAX1/NR0B1 gene mutations]. 61
21029627 2010
5
Familial risks for hospitalization with endocrine diseases. 61
18827002 2008
6
Blood eosinophilia, corticoadrenal insufficiency and eosinophilic cystitis. 61
18362497 2008
7
[Laparoscopic surgery for benign adrenal tumor: a report of 10 cases]. 61
15642205 2005
8
[Werner's syndrome and endocrine disorders]. 61
12910063 2003
9
Adrenopause: an imbalance between dehydroepiandrosterone (DHEA) and cortisol secretion. 61
12508910 2002
10
[Diagnosis of adrenal cortex insufficiency in steroid-dependent bronchial asthma--the CRH test in comparison with diurnal cortisol profile in serum and cortisol in 24-hour urine]. 61
7824500 1994
11
Repeatedly relapsing disseminated histoplasmosis: clinical observations during long-term follow-up. 61
3598232 1987
12
[Corticoadrenal insufficiency (Addison's disease)]. 61
6495444 1984
13
[Decrease of urinary adrenalin excretion in primary corticoadrenal insufficiency]. 61
4660453 1972
14
[Temporal distribution of treatment of corticoadrenal insufficiency. Chonotherapeutic trial]. 61
5139435 1971
15
[Clinical study on effect of simultaneous use of xylitol in the prevention of adrenal cortical hypofunction in corticoid therapy]. 61
4304514 1968
16
Occurrence of allergic disease in patients with adrenal cortical hypofunction. 61
13807987 1960
17
[Adrenergic vascular response and adrenal cortical hypofunction]. 61
14432109 1959
18
Adrenal cortical hypofunction in some cases of chronic amoebiasis. 61
13620929 1958
19
Eight patients with adrenal cortical hypofunction surviving more than fifteen years. 61
13271108 1955
20
Oral therapy of adrenal cortical hypofunction; use of combined fluorocortisone acetate and hydrocortisone. 61
13271094 1955
21
Adrenogenital virilism with adrenal cortical hypofunction; a clinical entity. 61
14361534 1955
22
Arthritis following use of desoxycorticosterone acetate and cortisone; occurrence in patient with adrenal cortical hypofunction. 61
14353638 1955
23
Temporary adrenal cortical hypofunction in newborns. 61
12984012 1952
24
POTASSIUM: A BASAL FACTOR IN THE SYNDROME OF CORTICOADRENAL INSUFFICIENCY. 61
17788915 1936

Variations for Adrenal Cortical Hypofunction

Expression for Adrenal Cortical Hypofunction

Search GEO for disease gene expression data for Adrenal Cortical Hypofunction.

Pathways for Adrenal Cortical Hypofunction

Pathways related to Adrenal Cortical Hypofunction according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.09 TPO TG POMC NR5A1 NR0B1 MC2R
2
Show member pathways
11.51 POMC MC2R CYP11A1
3
Show member pathways
11.4 POMC CYP21A2 CYP11A1
4 11.23 POMC CYP21A2 CYP11A1 CRH
5 10.1 POMC CRH
6 9.93 TPO TG

GO Terms for Adrenal Cortical Hypofunction

Cellular components related to Adrenal Cortical Hypofunction according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 secretory granule GO:0030141 8.8 TOR1A PTPRN POMC

Biological processes related to Adrenal Cortical Hypofunction according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 fatty acid homeostasis GO:0055089 9.48 INS ABCD1
2 thyroid hormone generation GO:0006590 9.46 TPO TG
3 hypothalamus development GO:0021854 9.43 NR0B1 CRH
4 hormone biosynthetic process GO:0042446 9.4 TPO TG
5 neuron projection maintenance GO:1990535 9.37 INS ABCD1
6 male sex determination GO:0030238 9.32 NR5A1 NR0B1
7 glucocorticoid biosynthetic process GO:0006704 9.26 CYP21A2 CYP11A1
8 sex determination GO:0007530 9.16 NR5A1 NR0B1
9 luteinization GO:0001553 8.96 PTPRN NR5A1
10 response to immobilization stress GO:0035902 8.8 REN NR0B1 CRH

Molecular functions related to Adrenal Cortical Hypofunction according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 insulin-like growth factor receptor binding GO:0005159 8.96 REN INS
2 hormone activity GO:0005179 8.92 TG POMC INS CRH

Sources for Adrenal Cortical Hypofunction

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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