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MCID: ADR010
MIFTS: 43

Adrenal Cortical Hypofunction

Categories: Endocrine diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Adrenal Cortical Hypofunction

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MalaCards integrated aliases for Adrenal Cortical Hypofunction:

Name: Adrenal Cortical Hypofunction 12 15 74
Adrenal Cortical Insufficiency 12
Corticoadrenal Insufficiency 12

Classifications:

MalaCards categories:
Anatomical: Endocrine diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:10493
ICD9CM 36 255.4
NCIt 51 C26691
SNOMED-CT 69 68588005
UMLS 74 C0405580
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Summaries for Adrenal Cortical Hypofunction

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MalaCards based summary : Adrenal Cortical Hypofunction, also known as adrenal cortical insufficiency, is related to adrenal hypoplasia, congenital and hypoadrenocorticism, familial. An important gene associated with Adrenal Cortical Hypofunction is NR0B1 (Nuclear Receptor Subfamily 0 Group B Member 1), and among its related pathways/superpathways are Aldosterone synthesis and secretion and Metabolism of steroid hormones. The drugs Hydrocortisone and Racepinephrine have been mentioned in the context of this disorder. Affiliated tissues include testes, pituitary and lung, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

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Related Diseases for Adrenal Cortical Hypofunction

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Diseases related to Adrenal Cortical Hypofunction via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 84)
# Related Disease Score Top Affiliating Genes
1 adrenal hypoplasia, congenital 31.8 GK IL1RAPL1 NR0B1 NR5A1
2 hypoadrenocorticism, familial 31.0 AIRE CRH CYP11A1 CYP21A2 NR0B1 POMC
3 achalasia-addisonianism-alacrima syndrome 11.4
4 premature ovarian failure 7 11.4
5 allergic encephalomyelitis 10.4 CRH POMC
6 hypothalamic disease 10.4 CRH POMC
7 gangliocytoma 10.4 CRH POMC
8 pituitary carcinoma 10.3 CRH POMC
9 type 1 diabetes mellitus 17 10.3 AIRE TNFRSF25
10 acth deficiency, isolated 10.3 CRH POMC
11 intrauterine growth retardation, metaphyseal dysplasia, adrenal hypoplasia congenita, and genital anomalies 10.3 GK NR0B1
12 46,xy partial gonadal dysgenesis 10.3 NR0B1 NR5A1
13 nelson syndrome 10.3 CRH POMC
14 sheehan syndrome 10.3 CRH POMC
15 autoimmune polyendocrine syndrome 10.3 AIRE CYP11A1
16 hypoadrenalism 10.3 CRH POMC
17 acth-secreting pituitary adenoma 10.3 CRH POMC
18 pyle disease 10.3 AIRE NR0B1
19 fasting hypoglycemia 10.3 CRH POMC
20 46,xx sex reversal 1 10.3 NR0B1 NR5A1
21 male reproductive organ benign neoplasm 10.3 NR5A1 POMC
22 withdrawal disorder 10.3 CRH POMC
23 ectopic cushing syndrome 10.3 CRH POMC
24 classic congenital adrenal hyperplasia due to 21-hydroxylase deficiency 10.2 CYP21A2 POMC
25 cytochrome p450 oxidoreductase deficiency 10.2 CYP21A2 POMC
26 vitiligo-associated multiple autoimmune disease susceptibility 6 10.2 AIRE PTPN22
27 persistent fetal circulation syndrome 10.2 CRH POMC
28 type 1 diabetes mellitus 2 10.2 PTPN22 TNFRSF25
29 autoimmune addison disease 10.2 AIRE CYP21A2
30 hypothyroidism, congenital, nongoitrous, 4 10.2 CRH POMC
31 adie pupil 10.2 TNFRSF25 TOR1A
32 type 1 diabetes mellitus 5 10.2 AIRE TNFRSF25
33 heart block, congenital 10.2 TNFRSF25 TOR1A
34 amenorrhea 10.2 CRH NR5A1 POMC
35 alternating hemiplegia of childhood 10.1 GK NR0B1 NR5A1
36 autoimmune polyendocrine syndrome type 1 10.1 AIRE CYP21A2
37 autoimmune disease of skin and connective tissue 10.1 TNFRSF25 TOR1A
38 46 xy gonadal dysgenesis 10.1 CYP11A1 NR0B1 NR5A1
39 immunoglobulin alpha deficiency 10.1 TNFRSF25 TOR1A
40 autoimmune disease of endocrine system 10.1 AIRE PTPN22 TNFRSF25
41 cystitis 10.1
42 hypereosinophilic syndrome 10.1
43 eosinophilic cystitis 10.1
44 pituitary-dependent cushing's disease 10.1 CRH CYP21A2 POMC
45 hypoaldosteronism 10.1 POMC REN
46 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 10.1 AIRE PTPN22
47 kleine-levin hibernation syndrome 10.1 POMC TOR1A
48 inappropriate adh syndrome 10.0 POMC REN
49 arthritis 10.0
50 adrenal rest tumor 10.0 CYP21A2 NR5A1 POMC

Graphical network of the top 20 diseases related to Adrenal Cortical Hypofunction:



Diseases related to Adrenal Cortical Hypofunction
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Symptoms & Phenotypes for Adrenal Cortical Hypofunction

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GenomeRNAi Phenotypes related to Adrenal Cortical Hypofunction according to GeneCards Suite gene sharing:

27 (show all 16)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-101 9.6 POMC
2 Increased shRNA abundance (Z-score > 2) GR00366-A-102 9.6 GK NR5A1 POMC
3 Increased shRNA abundance (Z-score > 2) GR00366-A-105 9.6 GK
4 Increased shRNA abundance (Z-score > 2) GR00366-A-11 9.6 GK
5 Increased shRNA abundance (Z-score > 2) GR00366-A-127 9.6 POMC
6 Increased shRNA abundance (Z-score > 2) GR00366-A-132 9.6 NR5A1
7 Increased shRNA abundance (Z-score > 2) GR00366-A-162 9.6 GK
8 Increased shRNA abundance (Z-score > 2) GR00366-A-202 9.6 NR5A1
9 Increased shRNA abundance (Z-score > 2) GR00366-A-29 9.6 POMC
10 Increased shRNA abundance (Z-score > 2) GR00366-A-30 9.6 GK
11 Increased shRNA abundance (Z-score > 2) GR00366-A-32 9.6 POMC
12 Increased shRNA abundance (Z-score > 2) GR00366-A-42 9.6 NR5A1
13 Increased shRNA abundance (Z-score > 2) GR00366-A-83 9.6 GK NR5A1
14 Increased shRNA abundance (Z-score > 2) GR00366-A-85 9.6 GK
15 Increased shRNA abundance (Z-score > 2) GR00366-A-88 9.6 POMC
16 Increased shRNA abundance (Z-score > 2) GR00366-A-9 9.6 POMC

MGI Mouse Phenotypes related to Adrenal Cortical Hypofunction:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 9.76 AIRE CRH CYP11A1 NR0B1 NR5A1 POMC
2 homeostasis/metabolism MP:0005376 9.61 AIRE CRH CYP11A1 NR0B1 NR5A1 POMC
3 nervous system MP:0003631 9.23 AIRE CRH CYP11A1 IL1RAPL1 NR5A1 POMC
Sources

Drugs & Therapeutics for Adrenal Cortical Hypofunction

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Drugs for Adrenal Cortical Hypofunction (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 258)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Hydrocortisone Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 50-23-7 5754
2
Racepinephrine Approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1 329-65-7 838
3
Epinephrine Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1 51-43-4 5816
4
Hydrocortisone acetate Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 50-03-3
5
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 1,Not Applicable 50-02-2 5743
6
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 4,Phase 1,Not Applicable 1177-87-3
7
Prednisolone phosphate Approved, Vet_approved Phase 4,Phase 3,Phase 2 302-25-0
8
Prednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2 50-24-8 5755
9
Methylprednisolone hemisuccinate Approved Phase 4,Phase 3,Phase 2 2921-57-5
10
Methylprednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2 83-43-2 6741
11
Prednisone Approved, Vet_approved Phase 4,Phase 3,Phase 2 53-03-2 5865
12
Cosyntropin Approved Phase 4,Phase 3,Not Applicable,Early Phase 1 16960-16-0 16129617
13
Triamcinolone Approved, Vet_approved Phase 4 124-94-7 31307
14
Etomidate Approved Phase 4,Phase 2,Phase 3,Not Applicable 33125-97-2 667484 36339
15
Propofol Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 3,Not Applicable 2078-54-8 4943
16
Xylometazoline Approved, Investigational Phase 4 526-36-3 5709
17
Celecoxib Approved, Investigational Phase 4,Phase 2 169590-42-5 2662
18
Citalopram Approved Phase 4 59729-33-8 2771
19
Benzocaine Approved, Investigational Phase 4,Phase 3,Phase 2 1994-09-7, 94-09-7 2337
20
tannic acid Approved Phase 4,Phase 3,Phase 2 1401-55-4
21
Ketamine Approved, Vet_approved Phase 4,Phase 2,Phase 3,Not Applicable 6740-88-1 3821
22
Megestrol acetate Approved, Investigational, Vet_approved Phase 4,Not Applicable 595-33-5 11683
23
Fludrocortisone Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 127-31-1 31378
24
Sulfamethazine Approved, Investigational, Vet_approved Phase 4 57-68-1 5327
25
Prednisolone hemisuccinate Experimental Phase 4,Phase 3,Phase 2 2920-86-7
26
Cortisone Experimental Phase 4,Not Applicable 53-06-5 222786
27 Hydrocortisone hemisuccinate Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
28 Anti-Inflammatory Agents Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
29 glucocorticoids Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
30 Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
31 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
32 Epinephryl borate Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1
33 Hydrocortisone 17-butyrate 21-propionate Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
34 Hormones Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
35 Hydrocortisone-17-butyrate Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
36 Vasoconstrictor Agents Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
37 Antineoplastic Agents, Hormonal Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
38 Adrenergic Agonists Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
39 Sympathomimetics Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
40 Adrenergic Agents Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
41 Adrenergic alpha-Agonists Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
42 Adrenergic beta-Agonists Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
43 Bronchodilator Agents Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
44 Gastrointestinal Agents Phase 4,Phase 3,Phase 1,Not Applicable
45 Neurotransmitter Agents Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1
46 Antiemetics Phase 4,Phase 3,Phase 1,Not Applicable
47 Autonomic Agents Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
48 Anti-Asthmatic Agents Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
49 Mydriatics Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
50 BB 1101 Phase 4,Phase 1,Not Applicable

Interventional clinical trials:

(show top 50) (show all 211)
# Name Status NCT ID Phase Drugs
1 Effect of Treatment With Stress-Doses Glucocorticoid in Patients With Acute Respiratory Distress Syndrome (ARDS) Unknown status NCT00773058 Phase 4 hydrocortisone;placebo
2 Modified-release Compared to Conventional Hydrocortisone on Diurnal Fatigue in Secondary Hypoadrenalism Unknown status NCT02282150 Phase 4 Hydrocortisone;Plenadren
3 The Effect of Branched-chain Amino Acid on the Improvement of Serum Albumin Level in Cirrhotic Patients With Ascites Unknown status NCT02755701 Phase 4 Branched-chain Amino Acid;Placebo
4 Test Predicting Adrenal Insufficiency in Volunteers Under Prednisone Treatment Completed NCT00975078 Phase 4 prednisone
5 Dual RElease Hydrocortisone Versus conventionAl Glucocorticoid replaceMent Therapy in Hypocortisolism (DREAM) Completed NCT02277587 Phase 4 Plenadren;Conventional glucocorticoid therapy
6 Hydrocortisone Replacement in Patients With Secondary Adrenal Insufficiency (SUPREME CORT) Completed NCT01546922 Phase 4 Hydrocortisone
7 Determination of Method-specific Normal Cortisol and Adrenal Hormone Responses to the Short Synacthen Test Completed NCT00851942 Phase 4 Synacthen (Tetracosactrin)
8 Evaluation of Efficacy and Hypothalamus-pituitary-adrenal Axis Suppression Due to Corticosteroids Intrabursal Injection Completed NCT01652495 Phase 4 methylprednisolone acetate;Triamcinolone Acetonide
9 Post Operative Hemodynamic Function After Anesthetic Induction With Etomidate for Cardiac Surgery With ECC Completed NCT00451776 Phase 4 etomidate;propofol
10 The Effect of Moderate-Dose Steroid Therapy in Sepsis Completed NCT01275638 Phase 4 Prednisolone
11 Low-dose Hydrocortisone in Acutely Burned Patients Completed NCT00149123 Phase 4 hydrocortisone 200 mg/day
12 Effect of Etomidate on Hemodynamics and Adrenocortical Function After Cardiac Surgery Completed NCT00415701 Phase 4 Etomidate;Propofol;Hydrocortisone;NaCl 0.9%
13 Short-term Prednisone to Treat STA Study(SPTSS) Completed NCT01837433 Phase 4 Prednisone 1 week;Prednisone 6 weeks
14 Omega-3 Fatty Acids in Bariatric Gastric Bypass Surgery: Effect on Liver Volume, Immune Response and Erythrocyte Function Completed NCT02206256 Phase 4 Omega-3 fatty acid capsules
15 Steroid Use in Pediatric Fluid and Vasoactive Infusion Dependent Shock - Pilot Study Completed NCT02044159 Phase 4 Hydrocortisone
16 Revival of Stem Cells in Addison's Study Completed NCT01371526 Phase 4 depot tetracosactide
17 Effectiveness of Escitalopram in Preventing or Reducing Depressive Symptoms in People Receiving Interleukin-2 Treatment Completed NCT00352885 Phase 4 Escitalopram;Placebo;IL-2
18 Taper Or Abrupt Steroid Stop: TOASSTtrial Recruiting NCT03153527 Phase 4 Prednisone
19 Comparison of Two Strategies of Glucocorticoid Withdrawal in Rheumatoid Arthritis Patients Recruiting NCT02997605 Phase 4 GlucoCorticoid
20 Etomidate Versus Ketamine for Emergency Endotracheal Intubation: a Prospective Randomized Clinical Trial Recruiting NCT02643381 Phase 4 Etomidate;Ketamine
21 Efficacy and Safety of Two Glucocorticoid Regimens in the Treatment of Sarcoidosis Recruiting NCT03265405 Phase 4 Low dose prednisolone;Medium dose prednisolone
22 Congenital Adrenal Hyperplasia Once Daily Hydrocortisone Treatment Recruiting NCT03760835 Phase 4 Conventional Glucocorticoids (immediate release hydrocortisone, cortisone acetate, prednisone, prednisolone, dexamethasone);Dual release hydrocortisone (plenadren)
23 Optimising Steroid Replacement in Patients With Adrenal Insufficiency Enrolling by invitation NCT03282487 Phase 4 Modified release hydrocortisone
24 A Study of Markers of Glucocorticoid Effects in Patients With Addisons Disease (DOSCORT) Not yet recruiting NCT03210545 Phase 4 Dexamethasone
25 iKanEat: A Randomized-controlled, Multi-center Trial of Megestrol for Chronic Oral Food Refusal in Children Not yet recruiting NCT03815019 Phase 4 Megestrol Acetate
26 Adrenal Insufficiency in Septic Shock Terminated NCT00842933 Phase 4 Corticosteroid;Corticosteroid
27 Neuropsychological Effects of Hydrocortisone in Patients With Partial Adrenal Insufficiency Terminated NCT01089075 Phase 4 Hydrocortisone;Placebo
28 Hemodynamic and Inflammatory Effects of Abrupt Versus Tapered Corticosteroid Discontinuation in Septic Shock Terminated NCT01150409 Phase 4 hydrocortisone;Normal Saline
29 Hydrocortisone Versus Hydrocortisone Plus Fludrocortisone for the Treatment of Adrenal Insufficiency in Severe Sepsis Withdrawn NCT00368381 Phase 4 Hydrocortisone
30 Comparison of Intramuscular and Intravenous ACTH Stimulation Test in Normal Volunteers Withdrawn NCT03752190 Phase 4 Cosyntropin
31 The Effect of Dexamethasone on Cortisol Levels in Patients Undergoing Thyroid Surgery Withdrawn NCT01045876 Phase 4 Dexamethasone
32 Septic Shock em Steroids Unknown status NCT01047670 Phase 2, Phase 3 Hydrocortisone
33 Treatment of Adrenal Insufficiency in Children Completed NCT02720952 Phase 3 Infacort®
34 Once-daily Oral Modified Release Hydrocortisone in Patients With Adrenal Insufficiency Completed NCT00915343 Phase 2, Phase 3 hydrocortisone (modified release), oral tablet 20 and 5 mg;Hydrocortisone, oral tablet, 10 mg
35 Dehydroepiandrosterone Substitution in Adolescent and Young Women With Central Adrenal Insufficiency Completed NCT00575341 Phase 3 Dehydroepiandrosterone;placebo
36 Extension Study for Patients Entered Into Study Infacort 003 Completed NCT02733367 Phase 3 Infacort®
37 Phase III Randomized, Double-Blind, Placebo-Controlled Study of Dehydroepiandrosterone Replacement for Primary Adrenal Insufficiency Completed NCT00004313 Phase 3 dehydroepiandrosterone
38 Treatment of Polytraumatisms With Corticoids Completed NCT00563303 Phase 2, Phase 3 hydrocortisone;NaCl
39 Corticosteroid Therapy for Glucocorticoid Insufficiency Related to Traumatic Brain Injury Completed NCT01093261 Phase 3 Placebo;Hydrocortisone Fludrocortisone
40 PREMILOC Trial to Prevent Bronchopulmonary Dysplasia in Very Preterm Neonates Completed NCT00623740 Phase 3 hydrocortisone;placebo
41 Early Use of Hydrocortisone in Hypotensive Very Low Birth Weight Infants Completed NCT00358748 Phase 3 Hydrocortisone
42 Mepolizumab Steroid-Sparing Study in Subjects With Severe Refractory Asthma Completed NCT01691508 Phase 3 Mepolizumab;Placebo;OCS (prednisone/prednisolone)
43 Combination of Corticotherapy and Intensive Insulin Therapy for Septic Shock Completed NCT00320099 Phase 3 recombinant human insulin;hydrocortisone;fludrocortisone;Hydrocortisone
44 Ketamine / Propofol Admixture "Ketofol" at Induction in the Critically Ill Against Etomidate: KEEP PACE Trial Completed NCT02105415 Phase 2, Phase 3 Ketamine / Propofol Admixture;Etomidate
45 Corticosteroid Therapy of Septic Shock - Corticus Completed NCT00147004 Phase 3 hydrocortisone sodium succinate;Placebo
46 Glucocorticoid Treatment in Addison's Disease Completed NCT01063569 Phase 2, Phase 3 Solu-Cortef (hydrocortisone);Cortef (hydrocortisone)
47 MD1003-AMN MD1003 in Adrenomyeloneuropathy Completed NCT02961803 Phase 2, Phase 3 MD1003 100 mg capsule;Placebo
48 Stem Cell Transplant for Inborn Errors of Metabolism Completed NCT00176904 Phase 2, Phase 3 Busulfan, Cyclophosphamide, Antithymocyte Globulin
49 Compassionate Treatment of Patients With Inborn Errors of Bile Acid Metabolism With Cholic Acid Completed NCT00007020 Phase 3 Cholic Acids
50 Is Adrenal Insufficiency Under-diagnosed in Hospitalized Cirrhosis Patients? Recruiting NCT03368066 Phase 3 Cosyntropin

Search NIH Clinical Center for Adrenal Cortical Hypofunction

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Genetic Tests for Adrenal Cortical Hypofunction

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Anatomical Context for Adrenal Cortical Hypofunction

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MalaCards organs/tissues related to Adrenal Cortical Hypofunction:

42
Testes, Pituitary, Lung, Brain, Kidney, Liver, Bone
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Publications for Adrenal Cortical Hypofunction

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Articles related to Adrenal Cortical Hypofunction:

(show top 50) (show all 55)
# Title Authors Year
1
Adrenal cortical insufficiency--a life threatening illness with multiple etiologies. ( 24529304 )
2013
2
Pituitary FDG uptake in a patient of lung cancer with bilateral adrenal metastases causing adrenal cortical insufficiency. ( 21716036 )
2011
3
Zinc metabolism in adrenal cortical insufficiency: effects of carbohydrate-active steroids. ( 6727650 )
1984
4
Adrenal cortical insufficiency in young chickens exposed to a high ambient temperature. ( 751049 )
1978
5
Effects of carbohydrate-active steroids and ACTH on visually-evoked responses in patients with adrenal cortical insufficiency. ( 179030 )
1975
6
Effects of decreased adrenal corticosteroids: changes in sleep in normal subjects and patients with adrenal cortical insufficiency. ( 4130607 )
1974
7
Chronic adrenal cortical insufficiency--Addison's disease. ( 4686622 )
1973
8
Ketotic hypoglycemia in a four-year-old boy with adrenal cortical insufficiency. ( 4339366 )
1972
9
Ultrastructure of the adrenal cortex in experimental adrenal cortical insufficiency induced in rats by immunization with adrenal antigen. ( 5782202 )
1969
10
Auditory detection and perception in normal man and in patients with adrenal cortical insufficiency: effect of adrenal cortical steroids. ( 4298249 )
1968
11
Studies on auditory thresholds in normal man and in patients with adrenal cortical insufficiency: the role of adrenal cortical steroids. ( 6023777 )
1967
12
Recurrent Cushing's disease and intermittent functional adrenal cortical insufficiency following subtotal adrenalectomy. ( 4294030 )
1967
13
Studies on olfactory thresholds in normal man and in patients with adrenal cortical insufficiency: the role of adrenal cortical steroids and of serum sodium concentration. ( 5925519 )
1966
14
Stuart factor (factor X) deficiency associated with renal and adrenal cortical insufficiency. ( 5933429 )
1966
15
STUDIES ON TASTE THRESHOLDS IN NORMAL MAN AND IN PATIENTS WITH ADRENAL CORTICAL INSUFFICIENCY: THE ROLE OF ADRENAL CORTICAL STEROIDS AND OF SERUM SODIUM CONCENTRATION. ( 16695903 )
1963
16
EFFECT OF ADMINISTERED ALDOSTERONE UPON ELECTROLYTE EXCRETION DURING AND AFTER PREGNANCY IN TWO WOMEN WITH ADRENAL CORTICAL INSUFFICIENCY. ( 14087604 )
1963
17
PRESENT STATUS OF THE PROBLEM OF IATROGENIC ADRENAL CORTICAL INSUFFICIENCY. ( 14044777 )
1963
18
A syndrome resembling adrenal cortical insufficiency associated with long term busulfan (myleran) therapy. ( 14461123 )
1961
19
Water diuresis in adrenal cortical insufficiency. ( 13855065 )
1960
20
Urinary sodium retention after ACTH stimulation: a rapid, simple screening test for adrenal cortical insufficiency. ( 13797479 )
1960
21
Occurrence of allergic disease in patients with adrenal cortical hypofunction. ( 13807987 )
1960
22
Adrenal cortical hypofunction in some cases of chronic amoebiasis. ( 13620929 )
1958
23
Influence of hydration, venous pooling and adrenal cortical insufficiency on postural antidiuresis and antisaluresis. ( 13462932 )
1957
24
Postoperative acute adrenal cortical insufficiency. ( 13462740 )
1957
25
Treatment of adrenal cortical insufficiency. ( 13436848 )
1957
26
Adrenal cortical insufficiency occurring during surgery and in the postoperative period. ( 13405190 )
1957
27
Effect of cortisone on the abnormal distribution of intravascular water in adrenal cortical insufficiency in man. ( 13385573 )
1957
28
Urinary sodium and chloride determinations as an aid in the diagnosis of adrenal cortical insufficiency. ( 13381905 )
1956
29
ADRENAL cortical insufficiency. ( 13381144 )
1956
30
Acute adrenal cortical insufficiency; precipitation by infection during prolonged cortisone treatment. ( 13318956 )
1956
31
Treatment of adrenal cortical insufficiency during surgical procedures. ( 13306536 )
1956
32
Postoperative adrenal cortical insufficiency. ( 13234920 )
1955
33
Urinary alpha-ketolic steroid metabolites of cortical hormones administered to subjects with adrenal cortical insufficiency. ( 13233351 )
1955
34
Use of ACTH in the diagnosis of adrenal cortical insufficiency. ( 13218033 )
1955
35
Adrenal cortical insufficiency in infants simulating high intestinal obstruction. ( 13238654 )
1955
36
Adrenogenital virilism with adrenal cortical hypofunction; a clinical entity. ( 14361534 )
1955
37
Arthritis following use of desoxycorticosterone acetate and cortisone; occurrence in patient with adrenal cortical hypofunction. ( 14353638 )
1955
38
Eight patients with adrenal cortical hypofunction surviving more than fifteen years. ( 13271108 )
1955
39
Oral therapy of adrenal cortical hypofunction; use of combined fluorocortisone acetate and hydrocortisone. ( 13271094 )
1955
40
Surgically precipitated adrenal cortical insufficiency in a patient previously receiving cortisone. ( 13116676 )
1954
41
Adrenal cortical insufficiency associated with esinopenia. ( 13069586 )
1953
42
Fatal adrenal cortical insufficiency precipitated by surgery during prolonged continuous cortisone treatment. ( 13065993 )
1953
43
Postoperative adrenal cortical insufficiency; occurrence in patients previously treated with cortisone. ( 13061310 )
1953
44
Oral use of cortisone in chronic adrenal cortical insufficiency; study of six cases. ( 14927365 )
1952
45
The influence of anesthesia, operation, and obstetrical delivery upon patients with adrenal cortical insufficiency. ( 14913468 )
1952
46
Adrenal cortical insufficiency in the rhesus monkey. ( 12980075 )
1952
47
Temporary adrenal cortical hypofunction in newborns. ( 12984012 )
1952
48
Adrenal cortical insufficiency: psychological and neurological observations. ( 14879326 )
1951
49
Two cases of adrenal hyperplasia with adrenal cortical insufficiency. ( 14811527 )
1951
50
Clinical experience with the use of cortisone acetate pellets in the treatment of adrenal cortical insufficiency. ( 15436625 )
1950
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Variations for Adrenal Cortical Hypofunction

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Expression for Adrenal Cortical Hypofunction

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Search GEO for disease gene expression data for Adrenal Cortical Hypofunction.
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Pathways for Adrenal Cortical Hypofunction

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Pathways related to Adrenal Cortical Hypofunction according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Aldosterone synthesis and secretion 38
Show member pathways
 12.22 CYP11A1 CYP21A2 NR0B1 NR5A1 POMC
2
Metabolism of steroid hormones 67
Show member pathways
 11.38 CYP11A1 CYP21A2 POMC
3
Corticotropin-releasing hormone signaling pathway 1
10.89 CRH CYP11A1 CYP21A2 POMC
4
Glucocorticoid Pathway (HPA Axis), Pharmacodynamics 62
10 CRH POMC
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GO Terms for Adrenal Cortical Hypofunction

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Biological processes related to Adrenal Cortical Hypofunction according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 steroid metabolic process GO:0008202 9.63 CRH CYP11A1 CYP21A2
2 male gonad development GO:0008584 9.54 NR0B1 NR5A1 REN
3 intracellular receptor signaling pathway GO:0030522 9.49 NR0B1 NR5A1
4 sterol metabolic process GO:0016125 9.48 CYP11A1 CYP21A2
5 hypothalamus development GO:0021854 9.43 CRH NR0B1
6 steroid biosynthetic process GO:0006694 9.43 CYP11A1 CYP21A2 NR0B1
7 male sex determination GO:0030238 9.4 NR0B1 NR5A1
8 response to immobilization stress GO:0035902 9.33 CRH NR0B1 REN
9 sex determination GO:0007530 9.32 NR0B1 NR5A1
10 adrenal gland development GO:0030325 9.13 CRH NR0B1 NR5A1
11 glucocorticoid biosynthetic process GO:0006704 8.8 CRH CYP11A1 CYP21A2

Molecular functions related to Adrenal Cortical Hypofunction according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 signaling receptor binding GO:0005102 8.92 CRH IL1RAPL1 POMC REN
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Sources for Adrenal Cortical Hypofunction

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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