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MCID: ADR010
MIFTS: 37

Adrenal Cortical Hypofunction

Categories: Endocrine diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Adrenal Cortical Hypofunction

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MalaCards integrated aliases for Adrenal Cortical Hypofunction:

Name: Adrenal Cortical Hypofunction 12 15 73
Adrenal Cortical Insufficiency 12
Corticoadrenal Insufficiency 12

Classifications:

MalaCards categories:
Anatomical: Endocrine diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:10493
ICD9CM 35 255.4
NCIt 50 C26691
SNOMED-CT 68 68588005
UMLS 73 C0405580
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Summaries for Adrenal Cortical Hypofunction

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MalaCards based summary : Adrenal Cortical Hypofunction, also known as adrenal cortical insufficiency, is related to adrenal hypoplasia, congenital and hypoadrenocorticism, familial. An important gene associated with Adrenal Cortical Hypofunction is NR0B1 (Nuclear Receptor Subfamily 0 Group B Member 1), and among its related pathways/superpathways are Aldosterone synthesis and secretion and Metabolism of steroid hormones. The drugs Hydrocortisone acetate and Epinephrine have been mentioned in the context of this disorder. Affiliated tissues include pituitary, lung and cortex, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

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Related Diseases for Adrenal Cortical Hypofunction

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Diseases related to Adrenal Cortical Hypofunction via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 86)
# Related Disease Score Top Affiliating Genes
1 adrenal hypoplasia, congenital 31.9 NR5A1 NR0B1 IL1RAPL1 GK
2 hypoadrenocorticism, familial 31.4 PTPN22 POMC NR0B1 CYP21A2 CYP11A1 CRH
3 premature ovarian failure 7 11.7
4 achalasia-addisonianism-alacrima syndrome 11.4
5 gangliocytoma 10.2 POMC CRH
6 hypothalamic disease 10.2 POMC CRH
7 autoimmune polyendocrine syndrome 10.2 CYP11A1 AIRE
8 pituitary carcinoma 10.2 POMC CRH
9 type 1 diabetes mellitus 17 10.2 TNFRSF25 AIRE
10 acth deficiency, isolated 10.2 POMC CRH
11 hypoadrenalism 10.2 POMC CRH
12 sheehan syndrome 10.2 POMC CRH
13 46,xy partial gonadal dysgenesis 10.2 NR5A1 NR0B1
14 nelson syndrome 10.2 POMC CRH
15 acth-secreting pituitary adenoma 10.2 POMC CRH
16 fasting hypoglycemia 10.2 POMC CRH
17 pyle disease 10.2 NR0B1 AIRE
18 intrauterine growth retardation, metaphyseal dysplasia, adrenal hypoplasia congenita, and genital anomalies 10.2 NR0B1 GK
19 46,xx sex reversal 1 10.2 NR5A1 NR0B1
20 male reproductive organ benign neoplasm 10.2 POMC NR5A1
21 classic congenital adrenal hyperplasia due to 21-hydroxylase deficiency 10.2 POMC CYP21A2
22 cytochrome p450 oxidoreductase deficiency 10.2 CYP21A2 POMC
23 withdrawal disorder 10.2 POMC CRH
24 autoimmune addison disease 10.2 AIRE CYP21A2
25 persistent fetal circulation syndrome 10.2 POMC CRH
26 ectopic cushing syndrome 10.2 POMC CRH
27 hypothyroidism, congenital, nongoitrous, 4 10.2 POMC CRH
28 type 1 diabetes mellitus 5 10.1 TNFRSF25 AIRE
29 type 1 diabetes mellitus 2 10.1 TNFRSF25 PTPN22
30 vitiligo-associated multiple autoimmune disease susceptibility 6 10.1 PTPN22 AIRE
31 autoimmune polyendocrine syndrome type 1 10.1 CYP21A2 AIRE
32 cystitis 10.1
33 eosinophilic cystitis 10.1
34 sex differentiation disease 10.1 POMC CYP21A2
35 hypoaldosteronism 10.1 POMC REN
36 inappropriate adh syndrome 10.1 REN POMC
37 amenorrhea 10.1 POMC NR5A1 CRH
38 46 xy gonadal dysgenesis 10.1 NR5A1 NR0B1 CYP11A1
39 pituitary-dependent cushing's disease 10.1 POMC CYP21A2 CRH
40 alternating hemiplegia of childhood 10.1 NR5A1 NR0B1 GK
41 testicular leydig cell tumor 10.1 POMC CYP21A2 CYP11A1
42 hyperaldosteronism, familial, type i 10.1 REN POMC
43 malignant essential hypertension 10.1 TNFRSF25 REN
44 adrenal insufficiency, congenital, with 46,xy sex reversal, partial or complete 10.1 POMC CYP21A2 CYP11A1
45 autoimmune polyendocrine syndrome, type i, with or without reversible metaphyseal dysplasia 10.1 CYP21A2 CYP11A1 AIRE
46 adrenal rest tumor 10.1 POMC NR5A1 CYP21A2
47 autoimmune disease of endocrine system 10.0 TNFRSF25 PTPN22 AIRE
48 familial glucocorticoid deficiency 10.0 REN POMC NR0B1
49 arthritis 10.0
50 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 10.0 PTPN22 AIRE

Graphical network of the top 20 diseases related to Adrenal Cortical Hypofunction:



Diseases related to Adrenal Cortical Hypofunction
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Symptoms & Phenotypes for Adrenal Cortical Hypofunction

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GenomeRNAi Phenotypes related to Adrenal Cortical Hypofunction according to GeneCards Suite gene sharing:

26 (show all 16)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-101 9.6 POMC
2 Increased shRNA abundance (Z-score > 2) GR00366-A-102 9.6 GK NR5A1 POMC
3 Increased shRNA abundance (Z-score > 2) GR00366-A-105 9.6 GK
4 Increased shRNA abundance (Z-score > 2) GR00366-A-11 9.6 GK
5 Increased shRNA abundance (Z-score > 2) GR00366-A-127 9.6 POMC
6 Increased shRNA abundance (Z-score > 2) GR00366-A-132 9.6 NR5A1
7 Increased shRNA abundance (Z-score > 2) GR00366-A-162 9.6 GK
8 Increased shRNA abundance (Z-score > 2) GR00366-A-202 9.6 NR5A1
9 Increased shRNA abundance (Z-score > 2) GR00366-A-29 9.6 POMC
10 Increased shRNA abundance (Z-score > 2) GR00366-A-30 9.6 GK
11 Increased shRNA abundance (Z-score > 2) GR00366-A-32 9.6 POMC
12 Increased shRNA abundance (Z-score > 2) GR00366-A-42 9.6 NR5A1
13 Increased shRNA abundance (Z-score > 2) GR00366-A-83 9.6 GK NR5A1
14 Increased shRNA abundance (Z-score > 2) GR00366-A-85 9.6 GK
15 Increased shRNA abundance (Z-score > 2) GR00366-A-88 9.6 POMC
16 Increased shRNA abundance (Z-score > 2) GR00366-A-9 9.6 POMC

MGI Mouse Phenotypes related to Adrenal Cortical Hypofunction:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 9.76 AIRE CRH CYP11A1 NR0B1 NR5A1 POMC
2 homeostasis/metabolism MP:0005376 9.61 AIRE CRH CYP11A1 NR0B1 NR5A1 POMC
3 nervous system MP:0003631 9.23 AIRE CRH CYP11A1 IL1RAPL1 NR5A1 POMC
Sources

Drugs & Therapeutics for Adrenal Cortical Hypofunction

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Drugs for Adrenal Cortical Hypofunction (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 250)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Hydrocortisone acetate Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 50-03-3
2
Epinephrine Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1 51-43-4 5816
3
Hydrocortisone Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 50-23-7 5754
4
Racepinephrine Approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1 329-65-7 838
5
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 4,Phase 1,Not Applicable 1177-87-3
6
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 1,Not Applicable 50-02-2 5743
7
Prednisone Approved, Vet_approved Phase 4,Phase 3,Phase 2 53-03-2 5865
8
Cosyntropin Approved Phase 4,Phase 3,Not Applicable,Early Phase 1 16960-16-0 16129617
9
Cortisone acetate Approved, Investigational Phase 4,Not Applicable 1950-04-4, 50-04-4 5745
10
Methylprednisolone hemisuccinate Approved Phase 4,Phase 3,Phase 2 2921-57-5
11
Methylprednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2 83-43-2 6741
12
Prednisolone phosphate Approved, Vet_approved Phase 4,Phase 3,Phase 2 302-25-0
13
Triamcinolone Approved, Vet_approved Phase 4 124-94-7 31307
14
Prednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2 50-24-8 5755
15
Propofol Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 3,Not Applicable 2078-54-8 4943
16
Etomidate Approved Phase 4,Phase 2,Phase 3,Not Applicable 33125-97-2 667484 36339
17
Xylometazoline Approved, Investigational Phase 4 526-36-3 5709
18
Celecoxib Approved, Investigational Phase 4,Phase 2 169590-42-5 2662
19
Citalopram Approved Phase 4 59729-33-8 2771
20 tannic acid Approved Phase 4,Phase 3,Phase 2
21
Benzocaine Approved, Investigational Phase 4,Phase 3,Phase 2 94-09-7, 1994-09-7 2337
22
Ketamine Approved, Vet_approved Phase 4,Phase 2,Phase 3,Not Applicable 6740-88-1 3821
23
Fludrocortisone Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 127-31-1 31378
24
Sulfamethazine Approved, Investigational, Vet_approved Phase 4 57-68-1 5327
25
Cortisone Experimental Phase 4,Not Applicable 53-06-5 222786
26
Prednisolone hemisuccinate Experimental Phase 4,Phase 3,Phase 2 2920-86-7
27 glucocorticoids Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
28 Hydrocortisone-17-butyrate Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
29 Anti-Inflammatory Agents Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
30 Hormones Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
31 Epinephryl borate Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1
32 Hydrocortisone 17-butyrate 21-propionate Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
33 Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
34 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
35 Cortisol succinate Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
36 Sympathomimetics Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
37 Vasoconstrictor Agents Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
38 Adrenergic alpha-Agonists Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
39 Adrenergic beta-Agonists Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
40 Peripheral Nervous System Agents Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
41 Mydriatics Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
42 Adrenergic Agonists Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
43 Adrenergic Agents Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
44 Anti-Asthmatic Agents Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
45 Respiratory System Agents Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
46 BB 1101 Phase 4,Phase 1,Not Applicable
47 Autonomic Agents Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
48 Neurotransmitter Agents Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1
49 Bronchodilator Agents Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
50 Pharmaceutical Solutions Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable

Interventional clinical trials:

(show top 50) (show all 206)
# Name Status NCT ID Phase Drugs
1 Effect of Treatment With Stress-Doses Glucocorticoid in Patients With Acute Respiratory Distress Syndrome (ARDS) Unknown status NCT00773058 Phase 4 hydrocortisone;placebo
2 The Effect of Branched-chain Amino Acid on the Improvement of Serum Albumin Level in Cirrhotic Patients With Ascites Unknown status NCT02755701 Phase 4 Branched-chain Amino Acid;Placebo
3 Test Predicting Adrenal Insufficiency in Volunteers Under Prednisone Treatment Completed NCT00975078 Phase 4 prednisone
4 Dual RElease Hydrocortisone Versus conventionAl Glucocorticoid replaceMent Therapy in Hypocortisolism (DREAM) Completed NCT02277587 Phase 4 Plenadren;Conventional glucocorticoid therapy
5 Hydrocortisone Replacement in Patients With Secondary Adrenal Insufficiency (SUPREME CORT) Completed NCT01546922 Phase 4 Hydrocortisone
6 Determination of Method-specific Normal Cortisol and Adrenal Hormone Responses to the Short Synacthen Test Completed NCT00851942 Phase 4 Synacthen (Tetracosactrin)
7 Evaluation of Efficacy and Hypothalamus-pituitary-adrenal Axis Suppression Due to Corticosteroids Intrabursal Injection Completed NCT01652495 Phase 4 methylprednisolone acetate;Triamcinolone Acetonide
8 Post Operative Hemodynamic Function After Anesthetic Induction With Etomidate for Cardiac Surgery With ECC Completed NCT00451776 Phase 4 etomidate;propofol
9 The Effect of Moderate-Dose Steroid Therapy in Sepsis Completed NCT01275638 Phase 4 Prednisolone
10 Low-dose Hydrocortisone in Acutely Burned Patients Completed NCT00149123 Phase 4 hydrocortisone 200 mg/day
11 Effect of Etomidate on Hemodynamics and Adrenocortical Function After Cardiac Surgery Completed NCT00415701 Phase 4 Etomidate;Propofol;Hydrocortisone;NaCl 0.9%
12 Short-term Prednisone to Treat STA Study(SPTSS) Completed NCT01837433 Phase 4 Prednisone 1 week;Prednisone 6 weeks
13 Omega-3 Fatty Acids in Bariatric Gastric Bypass Surgery: Effect on Liver Volume, Immune Response and Erythrocyte Function Completed NCT02206256 Phase 4 Omega-3 fatty acid capsules
14 Steroid Use in Pediatric Fluid and Vasoactive Infusion Dependent Shock - Pilot Study Completed NCT02044159 Phase 4 Hydrocortisone
15 Revival of Stem Cells in Addison's Study Completed NCT01371526 Phase 4 depot tetracosactide
16 Effectiveness of Escitalopram in Preventing or Reducing Depressive Symptoms in People Receiving Interleukin-2 Treatment Completed NCT00352885 Phase 4 Escitalopram;Placebo;IL-2
17 Taper Or Abrupt Steroid Stop: TOASSTtrial Recruiting NCT03153527 Phase 4 Prednisone
18 Comparison of Two Strategies of Glucocorticoid Withdrawal in Rheumatoid Arthritis Patients Recruiting NCT02997605 Phase 4 GlucoCorticoid
19 Etomidate Versus Ketamine for Emergency Endotracheal Intubation: a Prospective Randomized Clinical Trial Recruiting NCT02643381 Phase 4 Etomidate;Ketamine
20 Efficacy and Safety of Two Glucocorticoid Regimens in the Treatment of Sarcoidosis Recruiting NCT03265405 Phase 4 Low dose prednisolone;Medium dose prednisolone
21 Congenital Adrenal Hyperplasia Once Daily Hydrocortisone Treatment Recruiting NCT03760835 Phase 4 Conventional Glucocorticoids (immediate release hydrocortisone, cortisone acetate, prednisone, prednisolone, dexamethasone);Dual release hydrocortisone (plenadren)
22 Optimising Steroid Replacement in Patients With Adrenal Insufficiency Enrolling by invitation NCT03282487 Phase 4 Modified release hydrocortisone
23 Modified-release Compared to Conventional Hydrocortisone on Diurnal Fatigue in Secondary Hypoadrenalism Enrolling by invitation NCT02282150 Phase 4 Hydrocortisone;Plenadren
24 Comparison of Intramuscular and Intravenous ACTH Stimulation Test in Normal Volunteers Not yet recruiting NCT03752190 Phase 4 Cosyntropin
25 A Study of Markers of Glucocorticoid Effects in Patients With Addisons Disease (DOSCORT) Not yet recruiting NCT03210545 Phase 4 Dexamethasone
26 iKanEat: A Randomized-controlled, Multi-center Trial of Megestrol for Chronic Oral Food Refusal in Children 9 Months to 5 Years 6 Months of Age Not yet recruiting NCT03815019 Phase 4 Megestrol Acetate
27 Adrenal Insufficiency in Septic Shock Terminated NCT00842933 Phase 4 Corticosteroid;Corticosteroid
28 Neuropsychological Effects of Hydrocortisone in Patients With Partial Adrenal Insufficiency Terminated NCT01089075 Phase 4 Hydrocortisone;Placebo
29 Hemodynamic and Inflammatory Effects of Abrupt Versus Tapered Corticosteroid Discontinuation in Septic Shock Terminated NCT01150409 Phase 4 hydrocortisone;Normal Saline
30 Hydrocortisone Versus Hydrocortisone Plus Fludrocortisone for the Treatment of Adrenal Insufficiency in Severe Sepsis Withdrawn NCT00368381 Phase 4 Hydrocortisone
31 The Effect of Dexamethasone on Cortisol Levels in Patients Undergoing Thyroid Surgery Withdrawn NCT01045876 Phase 4 Dexamethasone
32 Septic Shock em Steroids Unknown status NCT01047670 Phase 2, Phase 3 Hydrocortisone
33 Treatment of Adrenal Insufficiency in Children Completed NCT02720952 Phase 3 Infacort®
34 Once-daily Oral Modified Release Hydrocortisone in Patients With Adrenal Insufficiency Completed NCT00915343 Phase 2, Phase 3 hydrocortisone (modified release), oral tablet 20 and 5 mg;Hydrocortisone, oral tablet, 10 mg
35 Dehydroepiandrosterone Substitution in Adolescent and Young Women With Central Adrenal Insufficiency Completed NCT00575341 Phase 3 Dehydroepiandrosterone;placebo
36 Phase III Randomized, Double-Blind, Placebo-Controlled Study of Dehydroepiandrosterone Replacement for Primary Adrenal Insufficiency Completed NCT00004313 Phase 3 dehydroepiandrosterone
37 Treatment of Polytraumatisms With Corticoids Completed NCT00563303 Phase 2, Phase 3 hydrocortisone;NaCl
38 Corticosteroid Therapy for Glucocorticoid Insufficiency Related to Traumatic Brain Injury Completed NCT01093261 Phase 3 Placebo;Hydrocortisone Fludrocortisone
39 PREMILOC Trial to Prevent Bronchopulmonary Dysplasia in Very Preterm Neonates Completed NCT00623740 Phase 3 hydrocortisone;placebo
40 Early Use of Hydrocortisone in Hypotensive Very Low Birth Weight Infants Completed NCT00358748 Phase 3 Hydrocortisone
41 Mepolizumab Steroid-Sparing Study in Subjects With Severe Refractory Asthma Completed NCT01691508 Phase 3 Mepolizumab;Placebo;OCS (prednisone/prednisolone)
42 Combination of Corticotherapy and Intensive Insulin Therapy for Septic Shock Completed NCT00320099 Phase 3 recombinant human insulin;hydrocortisone;fludrocortisone;Hydrocortisone
43 Ketamine / Propofol Admixture "Ketofol" at Induction in the Critically Ill Against Etomidate: KEEP PACE Trial Completed NCT02105415 Phase 2, Phase 3 Ketamine / Propofol Admixture;Etomidate
44 Corticosteroid Therapy of Septic Shock - Corticus Completed NCT00147004 Phase 3 hydrocortisone sodium succinate;Placebo
45 Glucocorticoid Treatment in Addison's Disease Completed NCT01063569 Phase 2, Phase 3 Solu-Cortef (hydrocortisone);Cortef (hydrocortisone)
46 MD1003-AMN MD1003 in Adrenomyeloneuropathy Completed NCT02961803 Phase 2, Phase 3 MD1003 100 mg capsule;Placebo
47 Stem Cell Transplant for Inborn Errors of Metabolism Completed NCT00176904 Phase 2, Phase 3 Busulfan, Cyclophosphamide, Antithymocyte Globulin
48 Compassionate Treatment of Patients With Inborn Errors of Bile Acid Metabolism With Cholic Acid Completed NCT00007020 Phase 3 Cholic Acids
49 Is Adrenal Insufficiency Under-diagnosed in Hospitalized Cirrhosis Patients? Recruiting NCT03368066 Phase 3 Cosyntropin
50 Study to Evaluate Efficacy and Safety of Benralizumab in Reducing Oral Corticosteroid Use in Adult Patients With Severe Asthma Recruiting NCT03557307 Phase 3

Search NIH Clinical Center for Adrenal Cortical Hypofunction

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Genetic Tests for Adrenal Cortical Hypofunction

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Anatomical Context for Adrenal Cortical Hypofunction

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MalaCards organs/tissues related to Adrenal Cortical Hypofunction:

41
Pituitary, Lung, Cortex, Skin, Heart, T Cells, Adrenal Gland
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Publications for Adrenal Cortical Hypofunction

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Articles related to Adrenal Cortical Hypofunction:

(show top 50) (show all 54)
# Title Authors Year
1
Adrenal cortical insufficiency--a life threatening illness with multiple etiologies. ( 24529304 )
2013
2
Pituitary FDG uptake in a patient of lung cancer with bilateral adrenal metastases causing adrenal cortical insufficiency. ( 21716036 )
2011
3
Zinc metabolism in adrenal cortical insufficiency: effects of carbohydrate-active steroids. ( 6727650 )
1984
4
Adrenal cortical insufficiency in young chickens exposed to a high ambient temperature. ( 751049 )
1978
5
Effects of carbohydrate-active steroids and ACTH on visually-evoked responses in patients with adrenal cortical insufficiency. ( 179030 )
1975
6
Effects of decreased adrenal corticosteroids: changes in sleep in normal subjects and patients with adrenal cortical insufficiency. ( 4130607 )
1974
7
Chronic adrenal cortical insufficiency--Addison's disease. ( 4686622 )
1973
8
Ketotic hypoglycemia in a four-year-old boy with adrenal cortical insufficiency. ( 4339366 )
1972
9
Ultrastructure of the adrenal cortex in experimental adrenal cortical insufficiency induced in rats by immunization with adrenal antigen. ( 5782202 )
1969
10
Auditory detection and perception in normal man and in patients with adrenal cortical insufficiency: effect of adrenal cortical steroids. ( 4298249 )
1968
11
Recurrent Cushing's disease and intermittent functional adrenal cortical insufficiency following subtotal adrenalectomy. ( 4294030 )
1967
12
Studies on auditory thresholds in normal man and in patients with adrenal cortical insufficiency: the role of adrenal cortical steroids. ( 6023777 )
1967
13
Studies on olfactory thresholds in normal man and in patients with adrenal cortical insufficiency: the role of adrenal cortical steroids and of serum sodium concentration. ( 5925519 )
1966
14
PRESENT STATUS OF THE PROBLEM OF IATROGENIC ADRENAL CORTICAL INSUFFICIENCY. ( 14044777 )
1963
15
EFFECT OF ADMINISTERED ALDOSTERONE UPON ELECTROLYTE EXCRETION DURING AND AFTER PREGNANCY IN TWO WOMEN WITH ADRENAL CORTICAL INSUFFICIENCY. ( 14087604 )
1963
16
STUDIES ON TASTE THRESHOLDS IN NORMAL MAN AND IN PATIENTS WITH ADRENAL CORTICAL INSUFFICIENCY: THE ROLE OF ADRENAL CORTICAL STEROIDS AND OF SERUM SODIUM CONCENTRATION. ( 16695903 )
1963
17
A syndrome resembling adrenal cortical insufficiency associated with long term busulfan (myleran) therapy. ( 14461123 )
1961
18
Occurrence of allergic disease in patients with adrenal cortical hypofunction. ( 13807987 )
1960
19
Urinary sodium retention after ACTH stimulation: a rapid, simple screening test for adrenal cortical insufficiency. ( 13797479 )
1960
20
Water diuresis in adrenal cortical insufficiency. ( 13855065 )
1960
21
Adrenal cortical hypofunction in some cases of chronic amoebiasis. ( 13620929 )
1958
22
Effect of cortisone on the abnormal distribution of intravascular water in adrenal cortical insufficiency in man. ( 13385573 )
1957
23
Adrenal cortical insufficiency occurring during surgery and in the postoperative period. ( 13405190 )
1957
24
Treatment of adrenal cortical insufficiency. ( 13436848 )
1957
25
Postoperative acute adrenal cortical insufficiency. ( 13462740 )
1957
26
Influence of hydration, venous pooling and adrenal cortical insufficiency on postural antidiuresis and antisaluresis. ( 13462932 )
1957
27
Treatment of adrenal cortical insufficiency during surgical procedures. ( 13306536 )
1956
28
Acute adrenal cortical insufficiency; precipitation by infection during prolonged cortisone treatment. ( 13318956 )
1956
29
ADRENAL cortical insufficiency. ( 13381144 )
1956
30
Urinary sodium and chloride determinations as an aid in the diagnosis of adrenal cortical insufficiency. ( 13381905 )
1956
31
Eight patients with adrenal cortical hypofunction surviving more than fifteen years. ( 13271108 )
1955
32
Adrenogenital virilism with adrenal cortical hypofunction; a clinical entity. ( 14361534 )
1955
33
Oral therapy of adrenal cortical hypofunction; use of combined fluorocortisone acetate and hydrocortisone. ( 13271094 )
1955
34
Arthritis following use of desoxycorticosterone acetate and cortisone; occurrence in patient with adrenal cortical hypofunction. ( 14353638 )
1955
35
Use of ACTH in the diagnosis of adrenal cortical insufficiency. ( 13218033 )
1955
36
Urinary alpha-ketolic steroid metabolites of cortical hormones administered to subjects with adrenal cortical insufficiency. ( 13233351 )
1955
37
Postoperative adrenal cortical insufficiency. ( 13234920 )
1955
38
Adrenal cortical insufficiency in infants simulating high intestinal obstruction. ( 13238654 )
1955
39
Surgically precipitated adrenal cortical insufficiency in a patient previously receiving cortisone. ( 13116676 )
1954
40
Postoperative adrenal cortical insufficiency; occurrence in patients previously treated with cortisone. ( 13061310 )
1953
41
Fatal adrenal cortical insufficiency precipitated by surgery during prolonged continuous cortisone treatment. ( 13065993 )
1953
42
Adrenal cortical insufficiency associated with esinopenia. ( 13069586 )
1953
43
Temporary adrenal cortical hypofunction in newborns. ( 12984012 )
1952
44
Adrenal cortical insufficiency in the rhesus monkey. ( 12980075 )
1952
45
The influence of anesthesia, operation, and obstetrical delivery upon patients with adrenal cortical insufficiency. ( 14913468 )
1952
46
Oral use of cortisone in chronic adrenal cortical insufficiency; study of six cases. ( 14927365 )
1952
47
Two cases of adrenal hyperplasia with adrenal cortical insufficiency. ( 14811527 )
1951
48
Adrenal cortical insufficiency: psychological and neurological observations. ( 14879326 )
1951
49
Eosinophil and uric acid changes after epinephrine and adrenocorticotrophic hormone in normal patients and in adrenal cortical insufficiency. ( 15410758 )
1950
50
Clinical experience with the use of cortisone acetate pellets in the treatment of adrenal cortical insufficiency. ( 15436625 )
1950
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Variations for Adrenal Cortical Hypofunction

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Expression for Adrenal Cortical Hypofunction

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Search GEO for disease gene expression data for Adrenal Cortical Hypofunction.
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Pathways for Adrenal Cortical Hypofunction

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Pathways related to Adrenal Cortical Hypofunction according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Aldosterone synthesis and secretion 37
Show member pathways
 12.23 CYP11A1 CYP21A2 NR0B1 NR5A1 POMC
2
Metabolism of steroid hormones 66
Show member pathways
 11.44 CYP11A1 CYP21A2 POMC
3
Cushing syndrome 37
Show member pathways
 11.43 CRH CYP11A1 CYP21A2 NR5A1 POMC
4
Corticotropin-releasing hormone signaling pathway 1
11.23 CRH CYP11A1 CYP21A2 POMC
5
Glucocorticoid Pathway (HPA Axis), Pharmacodynamics 61
10.1 CRH POMC
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GO Terms for Adrenal Cortical Hypofunction

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Biological processes related to Adrenal Cortical Hypofunction according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 steroid metabolic process GO:0008202 9.63 CRH CYP11A1 CYP21A2
2 male gonad development GO:0008584 9.54 NR0B1 NR5A1 REN
3 intracellular receptor signaling pathway GO:0030522 9.49 NR0B1 NR5A1
4 sterol metabolic process GO:0016125 9.48 CYP11A1 CYP21A2
5 hypothalamus development GO:0021854 9.43 CRH NR0B1
6 steroid biosynthetic process GO:0006694 9.43 CYP11A1 CYP21A2 NR0B1
7 male sex determination GO:0030238 9.4 NR0B1 NR5A1
8 response to immobilization stress GO:0035902 9.33 CRH NR0B1 REN
9 sex determination GO:0007530 9.32 NR0B1 NR5A1
10 adrenal gland development GO:0030325 9.13 CRH NR0B1 NR5A1
11 glucocorticoid biosynthetic process GO:0006704 8.8 CRH CYP11A1 CYP21A2

Molecular functions related to Adrenal Cortical Hypofunction according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 signaling receptor binding GO:0005102 8.92 CRH IL1RAPL1 POMC REN
Sources

Sources for Adrenal Cortical Hypofunction

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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