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MCID: ADR012
MIFTS: 44

Adrenal Gland Disease

Categories: Endocrine diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Adrenal Gland Disease

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MalaCards integrated aliases for Adrenal Gland Disease:

Name: Adrenal Gland Disease 12 15 17
Adrenal Gland Diseases 44 70
Adrenal Gland Disorders 42

Classifications:

MalaCards categories:
Anatomical: Endocrine diseases
See all MalaCards categories (disease lists)
ICD10: 32


External Ids:

Disease Ontology 12 DOID:9553
ICD9CM 34 255.9
MeSH 44 D000307
NCIt 50 C26690
SNOMED-CT 67 30171000
ICD10 32 E27.9 E35.1
UMLS 70 C0001621
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Summaries for Adrenal Gland Disease

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MedlinePlus : 42 The adrenal glands are small glands located on top of each kidney. They produce hormones that you can't live without, including sex hormones and cortisol. Cortisol helps you respond to stress and has many other important functions. With adrenal gland disorders, your glands make too much or not enough hormones. In Cushing's syndrome, there's too much cortisol, while with Addison's disease, there is too little. Some people are born unable to make enough cortisol. Causes of adrenal gland disorders include Genetic mutations Tumors including pheochromocytomas Infections A problem in another gland, such as the pituitary, which helps to regulate the adrenal gland Certain medicines Treatment depends on which problem you have. Surgery or medicines can treat many adrenal gland disorders. NIH: National Institute of Child Health and Human Development

MalaCards based summary : Adrenal Gland Disease, also known as adrenal gland diseases, is related to waterhouse-friderichsen syndrome and corticosteroid-binding globulin deficiency. An important gene associated with Adrenal Gland Disease is MIR483 (MicroRNA 483), and among its related pathways/superpathways are Myometrial Relaxation and Contraction Pathways and Aldosterone synthesis and secretion. The drugs Iodine and Cadexomer iodine have been mentioned in the context of this disorder. Affiliated tissues include adrenal gland, pituitary and heart, and related phenotypes are Reduced mammosphere formation and behavior/neurological

Disease Ontology : 12 An endocrine system disease that is located in the adrenal gland.

Wikipedia : 73 Adrenal gland disorders (or diseases) are conditions that interfere with the normal functioning of the... more...

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Related Diseases for Adrenal Gland Disease

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Diseases related to Adrenal Gland Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 217)
# Related Disease Score Top Affiliating Genes
1 waterhouse-friderichsen syndrome 32.4 POMC MC2R
2 corticosteroid-binding globulin deficiency 32.3 POMC NR3C1 MC2R
3 corticosterone methyloxidase type i deficiency 32.2 REN POMC NR0B1 CYP11B2 CYP11B1
4 pheochromocytoma 30.5 SST REN PRL POMC CRH
5 pseudohypoaldosteronism 30.5 REN NR3C2 NR3C1 CYP11B2
6 hyperandrogenism 30.5 PRL POMC INS
7 lipoid congenital adrenal hyperplasia 30.4 REN POMC NR0B1 MC2R CYP11B2 CYP11B1
8 hypoglycemia 30.3 SST PRL POMC NR3C1 INS CRH
9 glucose metabolism disease 30.3 SST REN POMC MIR675 MIR483 MIR210
10 adrenal cortical carcinoma 30.1 PRKAR1A POMC NR0B1 MIR675 MIR483 MIR139
11 adenoma 30.0 SST REN PRL PRKAR1A POMC KCNJ5
12 conn's syndrome 30.0 SST REN PRL PRKAR1A POMC NR3C2
13 adrenal insufficiency, congenital, with 46,xy sex reversal, partial or complete 11.1
14 acute adrenal insufficiency 10.5 REN POMC
15 bronchial adenomas/carcinoids childhood 10.5 SST POMC
16 hypoaldosteronism 10.5 REN POMC CYP11B2
17 aldosterone-producing adenoma 10.5 KCNJ5 CYP11B2
18 alzheimer disease 16 10.5 POMC NR3C1
19 basophil adenoma 10.5 PRKAR1A POMC
20 inappropriate adh syndrome 10.5 REN POMC CRH
21 adenohypophysitis 10.5 PRL POMC
22 tuberculum sellae meningioma 10.5 PRL POMC
23 familial hypertension 10.5 REN NR3C2 CYP11B2
24 premenstrual tension 10.5 REN POMC
25 sella turcica neoplasm 10.5 PRL POMC
26 chiasmal syndrome 10.5 SST POMC
27 pseudohyperkalemia, familial, 2, due to red cell leak 10.5 REN NR3C2 CYP11B2
28 atypical depressive disorder 10.5 POMC NR3C1 CRH
29 multiple endocrine neoplasia 10.5 SST PRKAR1A POMC
30 gangliocytoma 10.5 PRL POMC CRH
31 dysthymic disorder 10.5 POMC INS CRH
32 functionless pituitary adenoma 10.5 SST POMC
33 acute stress disorder 10.5 POMC NR3C1 CRH
34 prolactin producing pituitary tumor 10.5 PRL POMC
35 acth deficiency, isolated 10.5 PRL POMC CRH
36 melancholia 10.5 PRL POMC CRH
37 hypertensive heart disease 10.5 REN NR3C2 CYP11B2
38 depression 10.5 PRL NR3C1 CRH
39 persistent fetal circulation syndrome 10.5 POMC INS CRH
40 inherited metabolic disorder 10.5 REN POMC MIR483 INS
41 chromophobe adenoma 10.5 PRL POMC
42 retinal microaneurysm 10.5 REN INS
43 apnea, obstructive sleep 10.5 REN NR3C2 INS
44 adrenal hypoplasia, congenital 10.5 POMC NR0B1 MC2R
45 functional colonic disease 10.5 SST CYP11B1
46 sexual sadism 10.5 PRL CRH
47 empty sella syndrome 10.5 PRL POMC INS
48 abnormality of glucagon secretion 10.5 SST NR3C1
49 abducens nerve disease 10.5 PRL POMC
50 tsh producing pituitary tumor 10.5 SST PRL POMC

Comorbidity relations with Adrenal Gland Disease via Phenotypic Disease Network (PDN):


Acute Cystitis Deficiency Anemia
Hypertension, Essential

Graphical network of the top 20 diseases related to Adrenal Gland Disease:



Diseases related to Adrenal Gland Disease
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Symptoms & Phenotypes for Adrenal Gland Disease

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GenomeRNAi Phenotypes related to Adrenal Gland Disease according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Reduced mammosphere formation GR00396-S 9.17 CYP11B1 KCNJ5 MC2R NR0B1 NR3C1 NR3C2

MGI Mouse Phenotypes related to Adrenal Gland Disease:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.1 ATP2B3 CRH CYP11B1 INS MC2R NR3C1
2 cardiovascular system MP:0005385 10 ATP2B3 CYP11B1 CYP11B2 INS KCNJ5 MC2R
3 adipose tissue MP:0005375 9.97 CRH CYP11B2 INS MC2R NR3C1 POMC
4 endocrine/exocrine gland MP:0005379 9.9 ARMC5 CRH CYP11B1 CYP11B2 INS MC2R
5 homeostasis/metabolism MP:0005376 9.8 ARMC5 CRH CYP11B1 CYP11B2 INS MC2R
6 renal/urinary system MP:0005367 9.23 CRH CYP11B1 CYP11B2 INS NR3C1 NR3C2
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Drugs & Therapeutics for Adrenal Gland Disease

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Drugs for Adrenal Gland Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 21)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Iodine Approved, Investigational Phase 3 7553-56-2 807
2
Cadexomer iodine Experimental Phase 3 94820-09-4
3
Hydrocortisone Approved, Vet_approved Phase 1 50-23-7 5754
4
Hydrocortisone acetate Approved, Vet_approved Phase 1 50-03-3
5 Hormone Antagonists Phase 1
6 Anti-Inflammatory Agents Phase 1
7 Hydrocortisone-17-butyrate Phase 1
8 glucocorticoids Phase 1
9 Hydrocortisone 17-butyrate 21-propionate Phase 1
10 Hydrocortisone hemisuccinate Phase 1
11
Pancrelipase Approved, Investigational 53608-75-6
12
Parathyroid hormone Approved, Investigational 9002-64-6
13
Epinephrine Approved, Vet_approved 51-43-4 5816
14
Racepinephrine Approved 329-65-7 838
15 pancreatin
16 Cola
17 Liver Extracts
18 Calcium, Dietary
19 Hormones
20 Epinephryl borate
21
Calcium Nutraceutical 7440-70-2 271

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Iodine I-131 Iodocholesterol, Its Use in Adrenal Screening Completed NCT00037843 Phase 3 I-131 Iodocholesterol
2 Interval Bolus Delivery of Subcutaneous Hydrocortisone Via Infusion Pump in Children With Congenital Adrenal Hyperplasia Recruiting NCT03718234 Phase 1 Subcutaneous hydrocortisone;Standard glucocorticoid therapy
3 Lipid-poor Adrenal Masses: Evaluation With Chemical Shift MRI Completed NCT00721929
4 EUS-guided FNA in the Study of the Adrenal Gland: National Retrospective Multicenter Study Completed NCT03327142
5 Randomized Controlled Trial Between PRA(Posterior Retroperitoneoscopic Adrenalectomy) and LA(Laparoscopic Adrenalectomy) Completed NCT01676025
6 Posterior Retroperitoneoscopic Approach Versus Transperitoneal Laparoscopic Approach in Management of Adrenal Tumors: A Randomized Comparative Study Completed NCT02618694
7 Analysis of the Distribution of Adrenal Steroids in Blood and Urine Measured by Mass Spectrometry Coupled to Liquid Chromatography in a Control Population Completed NCT04139447
8 Prospective Phenotyping of Autonomous Aldosterone Secretion: A Cohort Study Recruiting NCT03484130
9 Comprehensive Data Collection and Follow-Up for Patients With Thyroid, Parathyroid and Adrenal Disease Recruiting NCT03050762
10 Effectiveness Comparison of Medical Treatment and Unilateral Laparoscopic Adrenalectomy for Resistant Hypertension in Patients Concomitant With Adrenal Diseases: A Prospective, Multi-Center, Open-Labeled, Randomized Clinical Trial. Not yet recruiting NCT03535532 standard medical treatment

Search NIH Clinical Center for Adrenal Gland Disease

Cochrane evidence based reviews: adrenal gland diseases

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Genetic Tests for Adrenal Gland Disease

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Anatomical Context for Adrenal Gland Disease

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The Foundational Model of Anatomy Ontology organs/tissues related to Adrenal Gland Disease:

19
Adrenal Gland

MalaCards organs/tissues related to Adrenal Gland Disease:

40
Adrenal Gland, Pituitary, Heart, Cortex, Thyroid, Adrenal Cortex, Kidney
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Publications for Adrenal Gland Disease

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Articles related to Adrenal Gland Disease:

(show top 50) (show all 82)
# Title Authors PMID Year
1
Acute adrenal infarction as an incidental CT finding and a potential prognosis factor in severe SARS-CoV-2 infection: a retrospective cohort analysis on 219 patients. 42
32852586 2021
2
Cardiomyopathies and Adrenal Diseases. 42
32709015 2020
3
Endocrine changes in SARS-CoV-2 patients and lessons from SARS-CoV. 42
32527756 2020
4
Urinary free metanephrines measurement in dogs with adrenal gland diseases using a new simple liquid chromatography tandem mass spectrometry method. 61
33678734 2021
5
Update: Selective adrenal venous sampling (AVS) - Indication, technique, and significance. 61
33327032 2020
6
Cardiovascular and metabolic risk factors in patients with subclinical Cushing. 61
32300953 2020
7
Ultrasonographic measurement of adrenal gland-to-aorta ratio as a method of estimating adrenal size in dogs. 61
31727851 2020
8
Evaluating the correlation between adrenal gland dimensions and aortic diameter in healthy dogs. 61
31006908 2019
9
Lateral Transperitoneal Adrenalectomy Versus Posterior Retroperitoneoscopic Adrenalectomy for Benign Adrenal Gland Disease: Randomized Controlled Trial at a Single Tertiary Medical Center. 61
29189215 2019
10
COMPARISON OF TRANSCUTANEOUS ULTRASOUND AND COMPUTED TOMOGRAPHY EVALUATION OF KIDNEY SIZE AND EVALUATION OF ADRENAL GLAND SIZE USING ULTRASOUND IN A COLONY OF CALLIMICOS ( CALLIMICO GOELDII). 61
30592929 2018
11
Transperitoneal versus retroperitoneal laparoscopic adrenalectomy for adrenal tumours in adults. 61
30595004 2018
12
SBRT to adrenal metastases provides high local control with minimal toxicity. 61
29204525 2017
13
IMAGING DIAGNOSIS-RADIOGRAPHY AND ULTRASONOGRAPHY OF BILATERAL CONGENITAL URETEROVESICAL JUNCTION STENOSIS CAUSING HYDRONEPHROSIS AND HYDROURETER IN A FERRET (MUSTELA PUTORIUS FURO). 61
27490371 2017
14
Perioperative Management and Outcome of Bilateral Adrenalectomy in 9 Dogs. 61
27398811 2016
15
Contrast-enhanced ultrasonographic characteristics of adrenal glands in dogs with pituitary-dependent hyperadrenocorticism. 61
23441645 2013
16
[Laparoscopic adrenalectomy in surgery of the adrenal gland diseases]. 61
23705475 2013
17
Serum inhibin concentration in dogs with adrenal gland disease and in healthy dogs. 61
23311716 2013
18
Clinical approach to adrenal insufficiency in hospitalised patients. 61
21762316 2011
19
[Development and evolution of laparoscopic adrenalectomy in an specialized team: from the beginning to the outpatient setting]. 61
20172483 2010
20
Computed tomography findings in diseases of the adrenal gland. 61
19626294 2009
21
Adrenal gland disease in ferrets. 61
18165141 2008
22
Adrenal steroid metabolism in birds: anatomy, physiology, and clinical considerations. 61
18165137 2008
23
[Surgical treatment of 486 cases of adrenal gland diseases: a retrospective study]. 61
18476529 2007
24
The adrenal glands and their functions. 61
18020028 2007
25
Outcomes of adoption of adult laboratory ferrets after gonadectomy during a veterinary student teaching exercise. 61
17645296 2007
26
[Anaesthesia for patients with adrenal gland diseases]. 61
17366436 2007
27
Computed tomographic quantification of canine adrenal gland volume and attenuation. 61
17009504 2006
28
[Adrenal gland surgery]. 61
16408654 2005
29
Characterization of human NOV in biological fluids: an enzyme immunoassay for the quantification of human NOV in sera from patients with diseases of the adrenal gland and of the nervous system. 61
12519873 2003
30
[Psychiatric disorders in thyroid and adrenal gland diseases]. 61
11490892 2001
31
Primary adrenal non-Hodgkin's lymphoma associated with autoimmune hemolytic anemia: a case diagnosed by ultrasound-guided fine needle biopsy. 61
10638023 1999
32
[Suprarenal surgical pathology. Experience of 10 years and review of the literature]. 61
9622914 1998
33
[Adrenal gland diseases. Foreword]. 61
11776240 1998
34
Adrenal gland disease in ferrets. 61
9076915 1997
35
[Adrenal gland diseases--results of surgical treatment]. 61
9446387 1997
36
[Results of surgical treatment for adrenal gland diseases]. 61
9446395 1997
37
Evaluation of plasma androgen and estrogen concentrations in ferrets with hyperadrenocorticism. 61
8800255 1996
38
Videoendoscopic adrenalectomy: multicentric study from the Belgian Group for Endoscopic Surgery (BGES). 61
8803696 1996
39
[Imaging of adrenal gland diseases]. 61
8597492 1995
40
Early experience with laparoscopic approach for adrenalectomy. 61
8256217 1993
41
[Nuclear medicine diagnosis of adrenal gland diseases]. 61
8475610 1993
42
[Radiodiagnosis of adrenal gland diseases]. 61
1441208 1992
43
[Diagnosis and therapy of adrenal gland diseases]. 61
1320086 1992
44
[Key points in diagnosis and therapy of adrenal gland diseases: discussion]. 61
1619333 1992
45
[Imaging diagnosis of adrenal gland diseases]. 61
1619327 1992
46
[Test procedures for the diagnosis of adrenal gland diseases]. 61
1619326 1992
47
[Diagnosis of adrenal gland diseases]. 61
1619325 1992
48
[Surgical aspects of the treatment of adrenal gland diseases]. 61
2068884 1991
49
[Sonography of adrenal gland diseases in the newborn infant]. 61
3051357 1988
50
[Computerized tomography and nuclear magnetic resonance tomography in adrenal gland diseases]. 61
3078252 1987
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Variations for Adrenal Gland Disease

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Expression for Adrenal Gland Disease

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Search GEO for disease gene expression data for Adrenal Gland Disease.
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Pathways for Adrenal Gland Disease

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Pathways related to Adrenal Gland Disease according to GeneCards Suite gene sharing:

(show all 11)
# Super pathways Score Top Affiliating Genes
1
Myometrial Relaxation and Contraction Pathways 1
Show member pathways
 12.29 PRKAR1A KCNJ5 CRH ATP2B3
2
Aldosterone synthesis and secretion 36
Show member pathways
 12.09 POMC NR0B1 MC2R KCNJ5 INS CYP11B2
3
cAMP signaling pathway 36
11.96 SST POMC MC2R ATP2B3
4
Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways 1
11.67 SST PRKAR1A NR3C1 MIR210
5
Corticotropin-releasing hormone signaling pathway 1
11.62 POMC CYP11B1 CRH
6
Nuclear Receptor transcription pathway 65
Show member pathways
 11.59 NR3C2 NR3C1 NR0B1
7
Glucocorticoid receptor regulatory network 1
11.52 PRL POMC NR3C1
8
Metabolism of steroid hormones 65
Show member pathways
 11.48 POMC CYP11B2 CYP11B1
9
Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics 60
Show member pathways
 11.45 REN NR3C2 CYP11B2
10
Antipsychotics Pathway (Metabolic Side Effects), Pharmacodynamics 60
10.43 PRL POMC INS
11
Glucocorticoid Pathway (HPA Axis), Pharmacodynamics 60
10.1 POMC CRH
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GO Terms for Adrenal Gland Disease

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Cellular components related to Adrenal Gland Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.23 SST REN PRL POMC MIR210 MIR139

Biological processes related to Adrenal Gland Disease according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 regulation of blood pressure GO:0008217 9.54 REN POMC CYP11B1
2 hypothalamus development GO:0021854 9.49 NR0B1 CRH
3 C21-steroid hormone biosynthetic process GO:0006700 9.48 CYP11B2 CYP11B1
4 cellular response to potassium ion GO:0035865 9.46 CYP11B2 CYP11B1
5 intracellular steroid hormone receptor signaling pathway GO:0030518 9.43 NR3C2 NR3C1
6 glucocorticoid biosynthetic process GO:0006704 9.4 CYP11B2 CYP11B1
7 hormone-mediated apoptotic signaling pathway GO:0008628 9.32 SST CRH
8 cortisol biosynthetic process GO:0034651 9.26 CYP11B2 CYP11B1
9 cortisol metabolic process GO:0034650 9.16 CYP11B2 CYP11B1
10 aldosterone biosynthetic process GO:0032342 8.96 CYP11B2 CYP11B1
11 response to immobilization stress GO:0035902 8.8 REN NR0B1 CRH

Molecular functions related to Adrenal Gland Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 mRNA binding involved in posttranscriptional gene silencing GO:1903231 9.56 MIR675 MIR483 MIR210 MIR139
2 insulin-like growth factor receptor binding GO:0005159 9.32 REN INS
3 corticosterone 18-monooxygenase activity GO:0047783 9.16 CYP11B2 CYP11B1
4 hormone activity GO:0005179 9.02 SST PRL POMC INS CRH
5 steroid 11-beta-monooxygenase activity GO:0004507 8.96 CYP11B2 CYP11B1
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Sources for Adrenal Gland Disease

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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