Home
User Guide
What's in a MalaCard Search Guide Our Sources
Analysis Tools
GeneCards GeneAnalytics GeneAlaCart PathCards VarElect TGex
News and Views Disease Lists/Categories
About
About MalaCards Our Publications Academic Licensing Weizmann Institute LifeMap Discovery® Terms of Use MalaCards Team
MCID: ADR012
MIFTS: 51

Adrenal Gland Disease

Categories: Endocrine diseases
Genes Tissues Related diseases Publications Pathways Drugs
Sources

Aliases & Classifications for Adrenal Gland Disease

About this section

MalaCards integrated aliases for Adrenal Gland Disease:

Name: Adrenal Gland Disease 12 15
Adrenal Gland Diseases 44 73
Abnormality of the Adrenal Glands 29
Adrenal Gland Disorders 43

Classifications:

MalaCards categories:
Anatomical: Endocrine diseases
See all MalaCards categories (disease lists)
ICD10: 33


External Ids:

Disease Ontology 12 DOID:9553
ICD9CM 35 255 255.9
MeSH 44 D000307
NCIt 50 C26690
UMLS 73 C0001621
Sources

Summaries for Adrenal Gland Disease

About this section
MedlinePlus : 43 The adrenal glands are small glands located on top of each kidney. They produce hormones that you can't live without, including sex hormones and cortisol. Cortisol helps you respond to stress and has many other important functions. With adrenal gland disorders, your glands make too much or not enough hormones. In Cushing's syndrome, there's too much cortisol, while with Addison's disease, there is too little. Some people are born unable to make enough cortisol. Causes of adrenal gland disorders include Genetic mutations Tumors including pheochromocytomas Infections A problem in another gland, such as the pituitary, which helps to regulate the adrenal gland Certain medicinesTreatment depends on which problem you have. Surgery or medicines can treat many adrenal gland disorders. NIH: National Institute of Child Health and Human Development

MalaCards based summary : Adrenal Gland Disease, also known as adrenal gland diseases, is related to corticosteroid-binding globulin deficiency and waterhouse-friderichsen syndrome. An important gene associated with Adrenal Gland Disease is POMC (Proopiomelanocortin), and among its related pathways/superpathways are Aldosterone synthesis and secretion and Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways. The drugs Spironolactone and Hydrocortisone have been mentioned in the context of this disorder. Affiliated tissues include the adrenal gl, adrenal gland and testes, and related phenotypes are Reduced mammosphere formation and behavior/neurological

Disease Ontology : 12 An endocrine system disease that is located in the adrenal gland.

Wikipedia : 76 Adrenal gland disorders (or diseases) are conditions that interfere with the normal functioning of the... more...

Sources

Related Diseases for Adrenal Gland Disease

About this section

Diseases related to Adrenal Gland Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 89)
# Related Disease Score Top Affiliating Genes
1 corticosteroid-binding globulin deficiency 31.1 HSD11B2 NR3C1 POMC SERPINA6
2 waterhouse-friderichsen syndrome 10.9
3 acute adrenal insufficiency 10.9 POMC REN
4 inappropriate adh syndrome 10.8 POMC REN
5 bronchus adenoma 10.7 POMC SST
6 acidophil adenoma 10.7 POMC SST
7 allergic urticaria 10.7 CRH NR3C1
8 acth deficiency, isolated 10.7 CRH POMC
9 hypoaldosteronism 10.7 CYP11B2 POMC REN
10 familial glucocorticoid deficiency 10.6 NR0B1 POMC REN
11 gonadal disease 10.6 CRH NR0B1 POMC
12 urinary system disease 10.6 CRH POMC REN
13 postural hypotension 10.6 REN SST
14 hypoadrenalism 10.6 CRH POMC
15 adrenal rest tumor 10.6 CYP11B1 CYP11B2 POMC
16 arthrogryposis, distal, type 3 10.5 NR3C2 REN
17 mental depression 10.5 CRH NR3C1 POMC
18 persistent fetal circulation syndrome 10.5 CRH HSD11B2 POMC
19 adrenal cortical adenoma 10.5 CYP11B1 POMC PRKAR1A
20 chronic fatigue syndrome 10.5 CRH NR3C1 POMC
21 hormone producing pituitary cancer 10.5 PRKAR1A SST
22 ectopic cushing syndrome 10.4 CRH POMC SST
23 primary pigmented nodular adrenocortical disease 10.4 NR3C1 POMC PRKAR1A
24 mood disorder 10.4 CRH NR3C1 POMC
25 pseudohypoaldosteronism, type i, autosomal dominant 10.4 NR3C2 REN
26 fasting hypoglycemia 10.4 CRH POMC
27 glucose metabolism disease 10.4 POMC REN SST
28 pseudohyperkalemia, familial, 2, due to red cell leak 10.3 CYP11B2 NR3C2 REN
29 lipoid congenital adrenal hyperplasia 10.3 CYP11B1 CYP11B2 POMC REN
30 anuria 10.2 HSD11B2 NR3C2 REN
31 steroid inherited metabolic disorder 10.2 CYP11B1 CYP11B2 HSD11B2 POMC
32 aldosterone-producing adenoma 10.2 CYP11B2 KCNJ5 REN
33 hypokalemia 10.2 HSD11B2 NR3C1 POMC REN
34 adenohypophysitis 10.1 POMC PRL
35 familial hyperaldosteronism 10.1 CYP11B1 CYP11B2 KCNJ5
36 pituitary apoplexy 10.0 POMC PRL
37 hypoadrenocorticism, familial 10.0 AIRE CRH NR0B1 POMC
38 sella turcica neoplasm 10.0 POMC PRL
39 tuberculum sellae meningioma 10.0 POMC PRL
40 hypothalamic disease 10.0 CRH POMC PRL
41 sheehan syndrome 10.0 CRH POMC PRL
42 adrenocortical carcinoma, hereditary 9.9 CYP11B1 CYP11B2 NR0B1 POMC PRKAR1A
43 melancholia 9.9 CRH PRL
44 amenorrhea 9.9 CRH POMC PRL
45 tsh producing pituitary tumor 9.9 PRL SST
46 empty sella syndrome 9.9 POMC PRL
47 hypopituitarism 9.9 CRH POMC PRL
48 pituitary adenoma 1, multiple types 9.8 PRL SST
49 anorexia nervosa 9.8 CRH POMC PRL
50 prolactin producing pituitary tumor 9.8 PRL SST

Comorbidity relations with Adrenal Gland Disease via Phenotypic Disease Network (PDN):


Acute Cystitis Deficiency Anemia
Hypertension, Essential

Graphical network of the top 20 diseases related to Adrenal Gland Disease:



Diseases related to Adrenal Gland Disease
Sources

Symptoms & Phenotypes for Adrenal Gland Disease

About this section

GenomeRNAi Phenotypes related to Adrenal Gland Disease according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Reduced mammosphere formation GR00396-S 9.17 CYP11B1 HSD11B2 KCNJ5 NR0B1 NR3C1 NR3C2

MGI Mouse Phenotypes related to Adrenal Gland Disease:

46 (show all 12)
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.29 REN POMC SERPINA6 PRKAR1A SST PRL
2 homeostasis/metabolism MP:0005376 10.28 POMC SERPINA6 PRKAR1A SST PRL REN
3 growth/size/body region MP:0005378 10.16 REN POMC SST PRKAR1A NR3C2 AIRE
4 cardiovascular system MP:0005385 10.15 REN POMC PRKAR1A NR3C2 HSD11B2 KCNJ5
5 endocrine/exocrine gland MP:0005379 10.13 POMC PRKAR1A PRL NR0B1 CRH NR3C1
6 immune system MP:0005387 10.1 REN POMC SERPINA6 SST PRKAR1A PRL
7 liver/biliary system MP:0005370 9.97 POMC SERPINA6 PRKAR1A PRL CRH NR3C1
8 nervous system MP:0003631 9.91 NR3C2 REN POMC SST PRL CYP11B2
9 neoplasm MP:0002006 9.8 POMC PRKAR1A PRL AIRE HSD11B2 NR0B1
10 no phenotypic analysis MP:0003012 9.63 POMC SERPINA6 SST AIRE CRH NR3C1
11 normal MP:0002873 9.5 REN SST PRKAR1A AIRE HSD11B2 CRH
12 renal/urinary system MP:0005367 9.28 REN POMC SERPINA6 NR3C2 HSD11B2 CRH
Sources

Drugs & Therapeutics for Adrenal Gland Disease

About this section

Drugs for Adrenal Gland Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 322)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Spironolactone Approved Phase 4,Not Applicable 1952-01-7, 52-01-7 5833
2
Hydrocortisone Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 50-23-7 5754
3
Captopril Approved Phase 4 62571-86-2 44093
4
Eplerenone Approved Phase 4,Not Applicable 107724-20-9 150310 443872
5
Dopamine Approved Phase 4 51-61-6, 62-31-7 681
6
Bromocriptine Approved, Investigational Phase 4 25614-03-3 31101
7
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 50-02-2 5743
8
Epinephrine Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1 51-43-4 5816
9
Prednisone Approved, Vet_approved Phase 4,Phase 2,Phase 3 53-03-2 5865
10
Racepinephrine Approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1 329-65-7 838
11
Menthol Approved Phase 4 2216-51-5 16666
12
Losartan Approved Phase 4 114798-26-4 3961
13
Fludrocortisone Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 127-31-1 31378
14
Cortisone acetate Approved, Investigational Phase 4,Phase 2,Not Applicable 1950-04-4, 50-04-4 5745
15
Mifepristone Approved, Investigational Phase 4,Phase 3,Phase 2 84371-65-3 55245
16
Triamcinolone Approved, Vet_approved Phase 4 124-94-7 31307
17
Prednisolone Approved, Vet_approved Phase 4,Phase 2,Phase 3 50-24-8 5755
18
Angiotensin II Approved, Investigational Phase 4,Not Applicable 68521-88-0, 4474-91-3, 11128-99-7 172198 65143
19
Methylprednisolone Approved, Vet_approved Phase 4,Phase 2,Phase 3 83-43-2 6741
20
Cosyntropin Approved Phase 4,Phase 3,Phase 1,Not Applicable 16960-16-0 16129617
21
Butyric Acid Experimental, Investigational Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 107-92-6 264
22 Dexamethasone acetate Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 1177-87-3
23 diuretics Phase 4,Not Applicable
24 glucocorticoids Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
25 Dopamine agonists Phase 4
26
protease inhibitors Phase 4,Phase 2,Phase 1,Not Applicable
27 Respiratory System Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
28 Adrenergic Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
29 Adrenergic Agonists Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
30 Adrenergic alpha-Agonists Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
31 Mineralocorticoid Receptor Antagonists Phase 4,Phase 3,Not Applicable
32 Mineralocorticoids Phase 4,Phase 3,Phase 2,Not Applicable
33 Adrenergic beta-Agonists Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
34 Mydriatics Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
35 Gastrointestinal Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
36 Natriuretic Agents Phase 4,Not Applicable
37 Cortisol succinate Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
38 Neurotransmitter Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
39 HIV Protease Inhibitors Phase 4,Phase 2,Phase 1,Not Applicable
40 Anesthetics Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
41 Hormone Antagonists Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
42 Hormones Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
43 Diuretics, Potassium Sparing Phase 4,Not Applicable
44 Angiotensin-Converting Enzyme Inhibitors Phase 4,Not Applicable
45 Dopamine Agents Phase 4
46 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
47 Vasoconstrictor Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
48 Anti-Asthmatic Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
49 Hydrocortisone 17-butyrate 21-propionate Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
50 Hydrocortisone acetate Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable

Interventional clinical trials:

(show top 50) (show all 353)
# Name Status NCT ID Phase Drugs
1 Influence of Synacthen Infusion on the Results of Adrenal Venous Sampling in Patient With Primary Aldosteronism Unknown status NCT02127840 Phase 4 Synacthen infusion during adrenal venous sampling
2 Does Aldosterone Cause Hypertension by a Non-Renal Mechanism? Unknown status NCT00553722 Phase 4 Eplerenone;Placebo
3 The Therapeutic Effect of Bromocriptin in Patients With Primary Aldosteronism Unknown status NCT00451672 Phase 4 bromocriptine
4 Effect of Treatment With Stress-Doses Glucocorticoid in Patients With Acute Respiratory Distress Syndrome (ARDS) Unknown status NCT00773058 Phase 4 hydrocortisone;placebo
5 Glucocorticoid Receptor Blockade With Mifepristone in Patients With Mild Adrenal Hypercortisolism Completed NCT01990560 Phase 4 Mifepristone
6 Hydrocortisone Replacement in Patients With Secondary Adrenal Insufficiency (SUPREME CORT) Completed NCT01546922 Phase 4 Hydrocortisone
7 Revival of Stem Cells in Addison's Study Completed NCT01371526 Phase 4 depot tetracosactide
8 Kallikrein-kinin (KKS) and Renin-angiotensin-aldosterone System (RAAS) in Primary Aldosteronism Completed NCT00155064 Phase 4 captopril, Losartan (drug)
9 Test Predicting Adrenal Insufficiency in Volunteers Under Prednisone Treatment Completed NCT00975078 Phase 4 prednisone
10 Determination of Method-specific Normal Cortisol and Adrenal Hormone Responses to the Short Synacthen Test Completed NCT00851942 Phase 4 Synacthen (Tetracosactrin)
11 Dual RElease Hydrocortisone Versus conventionAl Glucocorticoid replaceMent Therapy in Hypocortisolism (DREAM) Completed NCT02277587 Phase 4 Plenadren;Conventional glucocorticoid therapy
12 Randomized Clinical Trial of Posterior Retroperitoneoscopic Adrenalectomy Versus Lateral Laparoscopic Adrenalectomy Completed NCT01959711 Phase 4
13 Evaluation of Efficacy and Hypothalamus-pituitary-adrenal Axis Suppression Due to Corticosteroids Intrabursal Injection Completed NCT01652495 Phase 4 methylprednisolone acetate;Triamcinolone Acetonide
14 Optimising Steroid Replacement in Patients With Adrenal Insufficiency Enrolling by invitation NCT03282487 Phase 4 Modified release hydrocortisone
15 Modified-release Compared to Conventional Hydrocortisone on Diurnal Fatigue in Secondary Hypoadrenalism Enrolling by invitation NCT02282150 Phase 4 Hydrocortisone;Plenadren
16 A Study of Markers of Glucocorticoid Effects in Patients With Addisons Disease (DOSCORT) Not yet recruiting NCT03210545 Phase 4 Dexamethasone
17 Neuropsychological Effects of Hydrocortisone in Patients With Partial Adrenal Insufficiency Terminated NCT01089075 Phase 4 Hydrocortisone;Placebo
18 Adrenal Insufficiency in Septic Shock Terminated NCT00842933 Phase 4 Corticosteroid;Corticosteroid
19 The Effect of Dexamethasone on Cortisol Levels in Patients Undergoing Thyroid Surgery Withdrawn NCT01045876 Phase 4 Dexamethasone
20 Hydrocortisone Versus Hydrocortisone Plus Fludrocortisone for the Treatment of Adrenal Insufficiency in Severe Sepsis Withdrawn NCT00368381 Phase 4 Hydrocortisone
21 COrticosteroid in Congenital Adrenal Hyperplasia Unknown status NCT02552251 Phase 2, Phase 3
22 Iodine I-131 Iodocholesterol, Its Use in Adrenal Screening Completed NCT00037843 Phase 3 I-131 Iodocholesterol
23 Treatment of Adrenal Insufficiency in Children Completed NCT02720952 Phase 3 Infacort®
24 Once-daily Oral Modified Release Hydrocortisone in Patients With Adrenal Insufficiency Completed NCT00915343 Phase 2, Phase 3 hydrocortisone (modified release), oral tablet 20 and 5 mg;Hydrocortisone, oral tablet, 10 mg
25 Dehydroepiandrosterone Substitution in Adolescent and Young Women With Central Adrenal Insufficiency Completed NCT00575341 Phase 3 Dehydroepiandrosterone;placebo
26 SPARTACUS: Subtyping Primary Aldosteronism: a Randomized Trial Comparing Adrenal Vein Sampling and Computed Tomography Scan. Completed NCT01096654 Phase 3
27 Phase III Randomized, Double-Blind, Placebo-Controlled Study of Dehydroepiandrosterone Replacement for Primary Adrenal Insufficiency Completed NCT00004313 Phase 3 dehydroepiandrosterone
28 Glucocorticoid Treatment in Addison's Disease Completed NCT01063569 Phase 2, Phase 3 Solu-Cortef (hydrocortisone);Cortef (hydrocortisone)
29 Changes in Adrenal Hormones During Adrenal Radiofrequency Ablation Completed NCT00997594 Phase 2, Phase 3
30 An Extension Study of CORLUX in the Treatment of Endogenous Cushing's Syndrome Completed NCT00936741 Phase 3 mifepristone
31 A Study of the Efficacy and Safety of CORLUX in the Treatment of Endogenous Cushing's Syndrome Completed NCT00569582 Phase 3 mifepristone
32 The Role of Mineralocorticoid Receptors in Vascular Function Completed NCT00759525 Phase 2, Phase 3 Glycyrrhetic Acid;Placebo
33 MD1003-AMN MD1003 in Adrenomyeloneuropathy Completed NCT02961803 Phase 2, Phase 3 MD1003 100 mg capsule;Placebo
34 Compassionate Use of CORLUX® (Mifepristone) in the Treatment of Signs and Symptoms of Endogenous Cushing's Syndrome Completed NCT01371565 Phase 3 Mifepristone
35 Corticosteroid Therapy for Glucocorticoid Insufficiency Related to Traumatic Brain Injury Completed NCT01093261 Phase 3 Placebo;Hydrocortisone Fludrocortisone
36 A Study of OSI-906 in Patients With Locally Advanced or Metastatic Adrenocortical Carcinoma Completed NCT00924989 Phase 3 OSI-906
37 Cisplatin-Based Chemotherapy and/or Surgery in Treating Young Patients With Adrenocortical Tumor Completed NCT00304070 Phase 3 doxorubicin hydrochloride;cisplatin;mitotane;etoposide
38 Stem Cell Transplant for Inborn Errors of Metabolism Completed NCT00176904 Phase 2, Phase 3 Busulfan, Cyclophosphamide, Antithymocyte Globulin
39 Trial in Locally Advanced and Metastatic Adrenocortical Carcinoma Treatment (FIRM-ACT) Completed NCT00094497 Phase 3 Etoposide;Doxorubicin;Cisplatin;Streptozotocin;Mitotane
40 Compassionate Treatment of Patients With Inborn Errors of Bile Acid Metabolism With Cholic Acid Completed NCT00007020 Phase 3 Cholic Acids
41 Adrenal Artery Ablation Treats Primary Aldosteronism Recruiting NCT03398785 Phase 3
42 A Study to Assess the Safety and Efficacy of Levoketoconazole in the Treatment of Endogenous Cushing's Syndrome. Recruiting NCT03277690 Phase 3 Levoketoconazole;Placebo
43 Effects of Metyrapone in Patients With Endogenous Cushing's Syndrome Recruiting NCT02297945 Phase 3 metyrapone
44 Combined FDG-PET and 123I-Iodometomidate Imaging for Adrenal Neoplasia Recruiting NCT02010957 Phase 3
45 Is Adrenal Insufficiency Under-diagnosed in Hospitalized Cirrhosis Patients? Recruiting NCT03368066 Phase 3 Cosyntropin
46 A Clinical Study to Evaluate the Efficacy and Safety of MIN-102 (IMP) in Male AMN Patients. Recruiting NCT03231878 Phase 2, Phase 3 MIN-102;Placebos
47 A Study of the Efficacy, Safety and Tolerability of Chronocort in Treating CAH Recruiting NCT03062280 Phase 3 Hydrocortisone
48 Comparison of Chronocort® With Standard Glucocorticoid Therapy in Patients With Congenital Adrenal Hyperplasia Recruiting NCT02716818 Phase 3 Chronocort®;standard glucocorticoid therapy
49 Efficacy of Adjuvant Mitotane Treatment (ADIUVO) Recruiting NCT00777244 Phase 3 MITOTANE
50 Extension Study for Patients Entered Into Study Infacort 003 Active, not recruiting NCT02733367 Phase 3 Infacort®

Search NIH Clinical Center for Adrenal Gland Disease

Cochrane evidence based reviews: adrenal gland diseases

Sources

Genetic Tests for Adrenal Gland Disease

About this section

Genetic tests related to Adrenal Gland Disease:

# Genetic test Affiliating Genes
1 Abnormality of the Adrenal Glands 29
Sources

Anatomical Context for Adrenal Gland Disease

About this section

The Foundational Model of Anatomy Ontology organs/tissues related to Adrenal Gland Disease:

19
The Adrenal Gl

MalaCards organs/tissues related to Adrenal Gland Disease:

41
Adrenal Gland, Testes, Pituitary, Kidney, Lung, Bone, Thyroid
Sources

Publications for Adrenal Gland Disease

About this section

Articles related to Adrenal Gland Disease:

# Title Authors Year
1
Lateral Transperitoneal Adrenalectomy Versus Posterior Retroperitoneoscopic Adrenalectomy for Benign Adrenal Gland Disease: Randomized Controlled Trial at a Single Tertiary Medical Center. ( 29189215 )
2017
2
Serum inhibin concentration in dogs with adrenal gland disease and in healthy dogs. ( 23311716 )
2013
3
Adrenal gland disease in ferrets. ( 18165141 )
2008
4
Adrenal gland disease in ferrets. ( 9076915 )
1997
Sources

Variations for Adrenal Gland Disease

About this section
Sources

Expression for Adrenal Gland Disease

About this section
Search GEO for disease gene expression data for Adrenal Gland Disease.
Sources

Pathways for Adrenal Gland Disease

About this section

Pathways related to Adrenal Gland Disease according to GeneCards Suite gene sharing:

(show all 11)
# Super pathways Score Top Affiliating Genes
1
Aldosterone synthesis and secretion 37
Show member pathways
 12.29 ARMC5 CRH CYP11B1 CYP11B2 KCNJ5 POMC
2
Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways 1
11.88 NR3C1 PRKAR1A SST
3
Corticotropin-releasing hormone signaling pathway 1
11.6 CRH CYP11B1 POMC
4
Nuclear Receptor transcription pathway 66
Show member pathways
 11.56 NR0B1 NR3C1 NR3C2
5
Glucocorticoid receptor regulatory network 1
11.49 NR3C1 POMC PRL
6
Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics 61
Show member pathways
 11.4 CYP11B2 NR3C2 REN
7
Steroid hormone biosynthesis 37
Show member pathways
 11.25 CYP11B1 CYP11B2 HSD11B2
8
Metabolism of steroid hormones 66
Show member pathways
 10.87 CYP11B1 CYP11B2 HSD11B2 POMC
9
superpathway of steroid hormone biosynthesis 1
Show member pathways
 10.8 CYP11B1 CYP11B2
10
Glucocorticoid Pathway (Peripheral Tissue), Pharmacodynamics 61
10.37 NR3C1 SERPINA6
11
Glucocorticoid Pathway (HPA Axis), Pharmacodynamics 61
10 CRH POMC
Sources

GO Terms for Adrenal Gland Disease

About this section

Biological processes related to Adrenal Gland Disease according to GeneCards Suite gene sharing:

(show all 24)
# Name GO ID Score Top Affiliating Genes
1 response to drug GO:0042493 9.89 CRH HSD11B2 REN SST
2 steroid metabolic process GO:0008202 9.77 CRH CYP11B1 CYP11B2
3 female pregnancy GO:0007565 9.75 CRH HSD11B2 PRL
4 regulation of blood pressure GO:0008217 9.71 CYP11B1 POMC REN
5 steroid biosynthetic process GO:0006694 9.7 CYP11B1 CYP11B2 NR0B1
6 steroid hormone mediated signaling pathway GO:0043401 9.69 NR0B1 NR3C1 NR3C2
7 sterol metabolic process GO:0016125 9.62 CYP11B1 CYP11B2
8 cellular response to peptide hormone stimulus GO:0071375 9.61 CYP11B1 CYP11B2
9 adrenal gland development GO:0030325 9.61 CRH NR0B1
10 hypothalamus development GO:0021854 9.58 CRH NR0B1
11 C21-steroid hormone biosynthetic process GO:0006700 9.57 CYP11B1 CYP11B2
12 small molecule metabolic process GO:0044281 9.56 CYP11B1 CYP11B2
13 cellular response to potassium ion GO:0035865 9.55 CYP11B1 CYP11B2
14 glucocorticoid metabolic process GO:0008211 9.49 HSD11B2 SERPINA6
15 hormone-mediated apoptotic signaling pathway GO:0008628 9.48 CRH SST
16 secondary metabolite biosynthetic process GO:0044550 9.46 CYP11B1 CYP11B2
17 dehydroaustinol biosynthetic process GO:1900563 9.43 CYP11B1 CYP11B2
18 cortisol metabolic process GO:0034650 9.4 CYP11B1 CYP11B2
19 aldosterone biosynthetic process GO:0032342 9.37 CYP11B1 CYP11B2
20 austinol biosynthetic process GO:1900560 9.32 CYP11B1 CYP11B2
21 cortisol biosynthetic process GO:0034651 9.26 CYP11B1 CYP11B2
22 regulation of blood volume by renal aldosterone GO:0002017 9.16 CYP11B2 HSD11B2
23 response to immobilization stress GO:0035902 9.13 CRH NR0B1 REN
24 glucocorticoid biosynthetic process GO:0006704 8.92 CRH CYP11B1 CYP11B2 HSD11B2

Molecular functions related to Adrenal Gland Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 steroid hormone receptor activity GO:0003707 9.5 NR0B1 NR3C1 NR3C2
2 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen GO:0016709 9.37 CYP11B1 CYP11B2
3 corticosterone 18-monooxygenase activity GO:0047783 9.26 CYP11B1 CYP11B2
4 hormone activity GO:0005179 9.26 CRH POMC PRL SST
5 steroid 11-beta-monooxygenase activity GO:0004507 9.16 CYP11B1 CYP11B2
6 steroid binding GO:0005496 8.92 HSD11B2 NR3C1 NR3C2 SERPINA6
Sources

Sources for Adrenal Gland Disease

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Content
Loading form....