MCID: ADR012
MIFTS: 49

Adrenal Gland Disease

Categories: Cancer diseases, Endocrine diseases, Nephrological diseases
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Aliases & Classifications for Adrenal Gland Disease

MalaCards integrated aliases for Adrenal Gland Disease:

Name: Adrenal Gland Disease 11 14 16
Adrenal Gland Diseases 43 71
Adrenal Gland Disorders 41

Classifications:



External Ids:

Disease Ontology 11 DOID:9553
ICD9CM 34 255.9
MeSH 43 D000307
NCIt 49 C26690
SNOMED-CT 68 30171000
ICD10 31 E27.9 E35.1
UMLS 71 C0001621

Summaries for Adrenal Gland Disease

MedlinePlus: 41 What are adrenal glands? Your adrenal glands are two small organs that sit on top of each kidney. The adrenal glands make different types of hormones you need to stay alive and healthy. Hormones are chemicals that travel in your bloodstream and control how different parts of your body work. The adrenal glands make the hormones cortisol, aldosterone, adrenaline, and noradrenaline. They also make hormones that your body uses to make sex hormones (estrogen and testosterone). All of these hormones do many important jobs, including: Turning food into energy and managing blood sugar levels Balancing salt and water Keeping blood pressure normal Responding to illness and stress (your "fight or flight" response) Timing when and how fast a child develops sexually Supporting pregnancy What are adrenal gland disorders? When you have an adrenal gland disorder, your body makes too much or too little of one or more hormones. The symptoms depend on the type of problem you have and how much it affects the hormone levels in your body. There are many types of adrenal gland disorders, including: Addison's Disease - a condition in which the adrenal glands don't make enough cortisol Cushing's Syndrome - a condition caused by too much cortisol in the body, often from taking steroid medicines for a long time Aldosterone-producing adenoma - a benign tumor (not cancer) that makes too much aldosterone and may cause serious high blood pressure Hereditary paraganglioma-pheochromocytoma - an inherited condition causing different types of tumors that make adrenaline and other hormones. Some tumors may become cancerous. Adrenal gland cancer - cancerous tumors, including adrenocortical carcinoma and neuroblastoma Congenital Adrenal Hyperplasia (CAH) - a group of inherited disorders in which the adrenal glands don't make enough cortisol. The most common type is 21-hydroxylase deficiency (also called CAH1). In the United States, newborn babies get a blood test to see if they have CAH. People born with CAH may not have symptoms until childhood or later in life. What causes adrenal gland disorders? The cause of adrenal gland disorders depends on the type of disorder you have. Causes can include: Medicines such as steroids A problem in another gland, such as the pituitary gland. The pituitary gland releases hormones that affect how the adrenal glands work. Changes in genes (mutations). These changes can cause the adrenal glands to make too much or too little of one or more hormones. Infections In many cases the cause of the problem isn't clear. How are adrenal gland disorders diagnosed? Health care providers use different tests to check for adrenal disorders depending on your symptoms and health history. For example, you may have tests of your blood, urine (pee), or saliva (spit). These tests check your hormone levels. Your provider may order x-rays, CT scans, or MRI scans to look for tumors. What are the treatments for adrenal gland disorders? Different types of adrenal gland disorders have different treatments. They include medicines and surgery. Radiation therapy is sometimes a treatment for tumors. There are treatments to cure certain adrenal gland disorders. For other disorders, treatments can manage your symptoms. NIH: National Institute of Child Health and Human Development

MalaCards based summary: Adrenal Gland Disease, also known as adrenal gland diseases, is related to waterhouse-friderichsen syndrome and corticosteroid-binding globulin deficiency. An important gene associated with Adrenal Gland Disease is MIR483 (MicroRNA 483), and among its related pathways/superpathways are Myometrial relaxation and contraction pathways and ACE Inhibitor Pathway, Pharmacodynamics. The drugs Iodine and Cadexomer iodine have been mentioned in the context of this disorder. Affiliated tissues include adrenal gland, pituitary and kidney, and related phenotypes are Reduced mammosphere formation and homeostasis/metabolism

Disease Ontology: 11 An endocrine system disease that is located in the adrenal gland.

Related Diseases for Adrenal Gland Disease

Diseases related to Adrenal Gland Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 248)
# Related Disease Score Top Affiliating Genes
1 waterhouse-friderichsen syndrome 32.4 POMC MC2R CRH
2 corticosteroid-binding globulin deficiency 32.4 POMC NR3C1 MC2R
3 adrenal insufficiency, congenital, with 46,xy sex reversal, partial or complete 32.3 POMC NR0B1 MC2R CYP11B1
4 corticosterone methyloxidase type i deficiency 32.3 REN POMC NR0B1 CYP11B2 CYP11B1
5 premature ovarian failure 7 31.0 POMC CRH
6 pheochromocytoma 30.6 SST REN PRL POMC MEN1 CRH
7 hyperandrogenism 30.5 PRL POMC NR3C1 INS
8 pseudohypoaldosteronism 30.5 REN NR3C2 NR3C1
9 hypoadrenocorticism, familial 30.4 REN POMC NR0B1 MC2R CYP11B2 CRH
10 pituitary-dependent cushing's disease 30.4 SST PRL POMC NR3C1 MC2R CRH
11 hypoglycemia 30.3 SST PRL POMC NR3C1 KCNJ5 INS
12 adenoma 30.2 SST REN PRL PRKAR1A POMC MEN1
13 lipoid congenital adrenal hyperplasia 30.1 REN PRL POMC NR3C2 NR3C1 NR0B1
14 adrenal adenoma 30.0 REN PRKAR1A POMC NR3C2 MIR483 MEN1
15 adrenal cortical carcinoma 29.9 REN PRKAR1A POMC NR0B1 MIR483 MIR139
16 hypertension, essential 29.9 SST REN PRL POMC NR3C2 NR3C1
17 adrenal carcinoma 29.8 REN PRKAR1A POMC NR3C2 NR0B1 MIR483
18 conn's syndrome 29.6 SST REN PRL PRKAR1A POMC NR3C2
19 hypoaldosteronism 10.5 REN POMC CYP11B2
20 bronchial adenomas/carcinoids childhood 10.5 SST POMC
21 alzheimer disease 16 10.5 POMC NR3C1
22 basophil adenoma 10.5 PRKAR1A POMC
23 premenstrual tension 10.5 REN POMC
24 central pontine myelinolysis 10.5 REN POMC INS
25 cortisone reductase deficiency 10.5 POMC CYP11B2 CYP11B1
26 mediastinal lipomatosis 10.5 POMC NR3C1 CRH
27 neurotic disorder 10.5 POMC INS CRH
28 tuberculum sellae meningioma 10.5 PRL POMC
29 melancholia 10.5 PRL POMC CRH
30 acute stress disorder 10.5 POMC NR3C1 CRH
31 sexual sadism 10.5 PRL POMC CRH
32 sella turcica neoplasm 10.5 PRL POMC
33 functionless pituitary adenoma 10.5 SST POMC
34 acth deficiency, isolated 10.5 PRL POMC CRH
35 supine hypotensive syndrome 10.5 REN NR3C2 INS
36 diastolic heart failure 10.5 REN NR3C2 INS
37 melanotic neurilemmoma 10.5 PRL PRKAR1A POMC
38 dysthymic disorder 10.5 POMC INS CRH
39 chiasmal syndrome 10.5 SST PRL POMC
40 cavernous sinus thrombosis 10.5 POMC INS
41 chromophobe adenoma 10.5 PRL POMC
42 persistent fetal circulation syndrome 10.5 POMC INS CRH
43 systolic heart failure 10.5 REN NR3C2 INS
44 lipomatosis 10.5 MIR483 MEN1 INS
45 social phobia 10.5 PRL POMC CRH
46 intracranial hypertension 10.5 REN PRL POMC
47 tsh producing pituitary tumor 10.5 SST PRL POMC
48 prolactin producing pituitary tumor 10.5 PRL POMC MEN1
49 renal hypertension 10.5 REN NR3C2 INS
50 inherited metabolic disorder 10.5 REN MIR483 MIR210 INS

Comorbidity relations with Adrenal Gland Disease via Phenotypic Disease Network (PDN):


Acute Cystitis Deficiency Anemia
Hypertension, Essential

Graphical network of the top 20 diseases related to Adrenal Gland Disease:



Diseases related to Adrenal Gland Disease

Symptoms & Phenotypes for Adrenal Gland Disease

GenomeRNAi Phenotypes related to Adrenal Gland Disease according to GeneCards Suite gene sharing:

25
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Reduced mammosphere formation GR00396-S 9.23 CYP11B1 KCNJ5 MC2R MEN1 NR0B1 NR3C1

MGI Mouse Phenotypes related to Adrenal Gland Disease:

45 (show all 13)
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.34 ARMC5 CRH CYP11B1 CYP11B2 INS MC2R
2 nervous system MP:0003631 10.3 CRH CYP11B1 CYP11B2 INS MC2R MEN1
3 growth/size/body region MP:0005378 10.25 ARMC5 CRH CYP11B1 CYP11B2 INS MC2R
4 renal/urinary system MP:0005367 10.21 CRH CYP11B1 CYP11B2 INS MIR210 NR3C1
5 endocrine/exocrine gland MP:0005379 10.15 ARMC5 CRH CYP11B1 CYP11B2 INS MC2R
6 liver/biliary system MP:0005370 10.13 CRH CYP11B1 CYP11B2 INS MEN1 NR3C1
7 adipose tissue MP:0005375 10.11 CRH CYP11B1 CYP11B2 INS MC2R NR3C1
8 muscle MP:0005369 10.1 CYP11B1 CYP11B2 INS MEN1 NR3C1 NR3C2
9 behavior/neurological MP:0005386 10.1 ATP2B3 CRH CYP11B1 CYP11B2 INS MC2R
10 cardiovascular system MP:0005385 10.06 CYP11B1 CYP11B2 INS KCNJ5 MC2R MEN1
11 immune system MP:0005387 10 CRH CYP11B1 CYP11B2 INS MC2R MEN1
12 hematopoietic system MP:0005397 9.73 CRH CYP11B1 CYP11B2 INS MC2R MIR210
13 mortality/aging MP:0010768 9.47 ARMC5 CYP11B1 CYP11B2 INS MC2R MEN1

Drugs & Therapeutics for Adrenal Gland Disease

Drugs for Adrenal Gland Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 31)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Iodine Approved, Investigational Phase 3 7553-56-2 807
2
Cadexomer iodine Experimental Phase 3 94820-09-4
3
Hydrocortisone succinate Approved Phase 1 2203-97-6 3643
4
Hydrocortisone acetate Approved, Vet_approved Phase 1 50-03-3
5
Hydrocortisone Approved, Vet_approved Phase 1 50-23-7 3640 5754
6 Hormone Antagonists Phase 1
7 glucocorticoids Phase 1
8 Anti-Inflammatory Agents Phase 1
9 Hydrocortisone-17-butyrate Phase 1
10 Hydrocortisone 17-butyrate 21-propionate Phase 1
11
Pancrelipase Approved, Investigational 53608-75-6 8519
12
Parathyroid hormone Approved, Investigational 9002-64-6
13
Racepinephrine Approved, Vet_approved 51-43-4, 329-65-7 838 5816
14 Liver Extracts
15 Pancreatin
16 Cola
17 Calcium, Dietary
18 Bronchodilator Agents
19 Adrenergic beta-Agonists
20 Neurotransmitter Agents
21 Adrenergic alpha-Agonists
22 Adrenergic Agonists
23 Adrenergic Agents
24 Anti-Asthmatic Agents
25 Vasoconstrictor Agents
26 Respiratory System Agents
27 Mydriatics
28 Sympathomimetics
29 Epinephryl borate
30 Hormones
31
Calcium Nutraceutical 7440-70-2 271

Interventional clinical trials:

(show all 12)
# Name Status NCT ID Phase Drugs
1 Iodine I-131 Iodocholesterol, Its Use in Adrenal Screening Completed NCT00037843 Phase 3 I-131 Iodocholesterol
2 Interval Bolus Delivery of Subcutaneous Hydrocortisone Via Infusion Pump in Children With Congenital Adrenal Hyperplasia Active, not recruiting NCT03718234 Phase 1 Subcutaneous hydrocortisone;Standard glucocorticoid therapy
3 Effectiveness Comparison of Medical Treatment and Unilateral Laparoscopic Adrenalectomy for Resistant Hypertension in Patients Concomitant With Adrenal Diseases: A Prospective, Multi-Center, Open-Labeled, Randomized Clinical Trial. Unknown status NCT03535532 standard medical treatment
4 Lipid-poor Adrenal Masses: Evaluation With Chemical Shift MRI Completed NCT00721929
5 EUS-guided FNA in the Study of the Adrenal Gland: National Retrospective Multicenter Study Completed NCT03327142
6 Posterior Retroperitoneoscopic Approach Versus Transperitoneal Laparoscopic Approach in Management of Adrenal Tumors: A Randomized Comparative Study Completed NCT02618694
7 Analysis of the Distribution of Adrenal Steroids in Blood and Urine Measured by Mass Spectrometry Coupled to Liquid Chromatography in a Control Population Completed NCT04139447
8 Randomized Controlled Trial Between PRA(Posterior Retroperitoneoscopic Adrenalectomy) and LA(Laparoscopic Adrenalectomy) Completed NCT01676025
9 Prospective Phenotyping of Autonomous Aldosterone Secretion: A Cohort Study Recruiting NCT03484130
10 Comprehensive Data Collection and Follow-Up for Patients With Thyroid, Parathyroid and Adrenal Disease Recruiting NCT03050762
11 Complication in Laparoscopic Renal and Adrenal Surgery (CLARAS): an International Multicenter Study Recruiting NCT05322265
12 Development of New Technology for One-step Diagnosis of Adrenal Diseases Based on Adrenal Hormone Panel Not yet recruiting NCT04948970

Search NIH Clinical Center for Adrenal Gland Disease

Cochrane evidence based reviews: adrenal gland diseases

Genetic Tests for Adrenal Gland Disease

Anatomical Context for Adrenal Gland Disease

Organs/tissues related to Adrenal Gland Disease:

FMA: Adrenal Gland
MalaCards : Adrenal Gland, Pituitary, Kidney, Thyroid, Liver, Adrenal Cortex, Cortex

Publications for Adrenal Gland Disease

Articles related to Adrenal Gland Disease:

(show top 50) (show all 57)
# Title Authors PMID Year
1
Contrast-enhanced ultrasound of adrenal hemorrhage: a helpful problem solving tool. 41
35437529 2022
2
Neutrophil gelatinase-associated lipocalin as an immunomodulator in endocrine hypertension. 41
36387895 2022
3
Giant pseudocyst of the retroperitoneal space mimicking a lesion arising from the left adrenal gland. 41
35593670 2022
4
Congenital lipoid adrenal hyperplasia in a Saudi infant. 62
36053179 2022
5
Nano gold-doped molecularly imprinted electrochemical sensor for rapid and ultrasensitive cortisol detection. 62
35259605 2022
6
Metabolic profile differences in ACTH-dependent and ACTH-independent Cushing syndrome. 62
35620164 2022
7
Update: Selective adrenal venous sampling (AVS) - Indication, technique, and significance. 62
33327032 2021
8
Effect of dexamethasone in patients with ARDS and COVID-19 - prospective, multi-centre, open-label, parallel-group, randomised controlled trial (REMED trial): A structured summary of a study protocol for a randomised controlled trial. 62
33648568 2021
9
Ultrasonographic measurement of adrenal gland-to-aorta ratio as a method of estimating adrenal size in dogs. 62
31727851 2020
10
Glucose metabolism disorders in patients with adrenal gland disorders: pathophysiology and management. 62
31721134 2020
11
Attention-Deficit/Hyperactivity Disorder, Its Pharmacotherapy, and Adrenal Gland Dysfunction: A Nationwide Population-Based Study in Taiwan. 62
32466107 2020
12
The adrenal cortex: Physiology and diseases in human pregnancy. 62
31284087 2019
13
Lateral Transperitoneal Adrenalectomy Versus Posterior Retroperitoneoscopic Adrenalectomy for Benign Adrenal Gland Disease: Randomized Controlled Trial at a Single Tertiary Medical Center. 62
29189215 2019
14
Transperitoneal versus retroperitoneal laparoscopic adrenalectomy for adrenal tumours in adults. 62
30595004 2018
15
COMPARISON OF TRANSCUTANEOUS ULTRASOUND AND COMPUTED TOMOGRAPHY EVALUATION OF KIDNEY SIZE AND EVALUATION OF ADRENAL GLAND SIZE USING ULTRASOUND IN A COLONY OF CALLIMICOS ( CALLIMICO GOELDII). 62
30592929 2018
16
Adrenal gland disorders, active component, U.S. Armed Forces, 2002-2017. 62
30620611 2018
17
Butterfly adrenal gland with maldevelopment of the mesonephric duct: A rare association in an adult patient. 62
29904505 2018
18
The Diagnostics of Human Steroid Hormone Disorders. 62
28795359 2018
19
SBRT to adrenal metastases provides high local control with minimal toxicity. 62
29204525 2017
20
Radioimmunoassay of chromogranin A and free metanephrines in diagnosis of pheochromocytoma. 62
28948824 2017
21
Adrenal disorders: Is there Any role for vitamin D? 62
27761790 2017
22
IMAGING DIAGNOSIS-RADIOGRAPHY AND ULTRASONOGRAPHY OF BILATERAL CONGENITAL URETEROVESICAL JUNCTION STENOSIS CAUSING HYDRONEPHROSIS AND HYDROURETER IN A FERRET (MUSTELA PUTORIUS FURO). 62
27490371 2017
23
Perioperative Management and Outcome of Bilateral Adrenalectomy in 9 Dogs. 62
27398811 2016
24
The clinical course of patients with adrenal incidentaloma: is it time to reconsider the current recommendations? 62
26024670 2015
25
Response of cortisol metabolites in the insulin tolerance test and Synacthen tests. 62
26680485 2015
26
Adrenal disease: a clinical update and overview of imaging. A review. 62
24621966 2014
27
Lipoproteins and Hedgehog signalling--possible implications for the adrenal gland function. 62
23992253 2013
28
Contrast-enhanced ultrasonographic characteristics of adrenal glands in dogs with pituitary-dependent hyperadrenocorticism. 62
23441645 2013
29
Serum inhibin concentration in dogs with adrenal gland disease and in healthy dogs. 62
23311716 2013
30
[Laparoscopic adrenalectomy--indications and selection criteria]. 62
22880271 2012
31
A unique case of synchronous functional adrenocortical adenoma and myelolipoma within the ectopic adrenal cortex in a child with Beckwith-Wiedemann syndrome. 62
22309953 2012
32
Clinical approach to adrenal insufficiency in hospitalised patients. 62
21762316 2011
33
Is there an association between non-functioning adrenal adenoma and endothelial dysfunction? 62
20530985 2011
34
[Management of adrenal incidentaloma: the position statement of the Croatian referral center for adrenal gland disorders]. 62
20540431 2010
35
Adrenal gland disorders. 62
19738188 2009
36
Carotid intima media thickness is increased and associated with morning cortisol in subjects with non-functioning adrenal incidentaloma. 62
19277910 2009
37
Non-functioning adrenal incidentalomas are associated with elevated D-dimer levels. 62
19636203 2009
38
[Adrenal gland disorders. Multiple but rarely specific clinical symptoms]. 62
18672659 2008
39
Adrenal gland disease in ferrets. 62
18165141 2008
40
Adrenal steroid metabolism in birds: anatomy, physiology, and clinical considerations. 62
18165137 2008
41
The adrenal glands and their functions. 62
18020028 2007
42
Association of restless legs syndrome in type 2 diabetes: a case-control study. 62
17682657 2007
43
Outcomes of adoption of adult laboratory ferrets after gonadectomy during a veterinary student teaching exercise. 62
17645296 2007
44
Computed tomographic quantification of canine adrenal gland volume and attenuation. 62
17009504 2006
45
Epidemiologic study of adrenal gland disorders in Japan. 62
10915016 2000
46
Primary adrenal non-Hodgkin's lymphoma associated with autoimmune hemolytic anemia: a case diagnosed by ultrasound-guided fine needle biopsy. 62
10638023 1999
47
[Suprarenal surgical pathology. Experience of 10 years and review of the literature]. 62
9622914 1998
48
Imaging of adrenal gland disorders. 62
9076905 1997
49
Adrenal gland disease in ferrets. 62
9076915 1997
50
Evaluation of plasma androgen and estrogen concentrations in ferrets with hyperadrenocorticism. 62
8800255 1996

Variations for Adrenal Gland Disease

Cosmic variations for Adrenal Gland Disease:

8 (show top 50) (show all 113)
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM88301868 VHL adrenal gland,adrenal gland,pheochromocytoma,benign c.389T>G p.V130G 3:10146562-10146562 12
2 COSM90654925 VHL adrenal gland,adrenal gland,pheochromocytoma,benign c.260T>C p.V87A 3:10142107-10142107 12
3 COSM88294143 VHL adrenal gland,adrenal gland,pheochromocytoma,benign c.260T>C p.V87A 3:10142107-10142107 12
4 COSM90652830 VHL adrenal gland,adrenal gland,pheochromocytoma,benign c.373G>T p.V125F 3:10149819-10149819 12
5 COSM88293303 VHL adrenal gland,adrenal gland,pheochromocytoma,benign c.475A>G p.K159E 3:10149798-10149798 12
6 COSM88288959 VHL adrenal gland,adrenal gland,pheochromocytoma,benign c.482G>A p.R161Q 3:10149805-10149805 12
7 COSM88296074 VHL adrenal gland,adrenal gland,pheochromocytoma,benign c.250G>C p.V84L 3:10142097-10142097 12
8 COSM88292246 VHL adrenal gland,adrenal gland,pheochromocytoma,benign c.227T>A p.F76Y 3:10142074-10142074 12
9 COSM90652721 VHL adrenal gland,adrenal gland,pheochromocytoma,benign c.368A>G p.Q123R 3:10149814-10149814 12
10 COSM88292324 VHL adrenal gland,adrenal gland,pheochromocytoma,benign c.496G>T p.V166F 3:10149819-10149819 12
11 COSM90657160 VHL adrenal gland,adrenal gland,pheochromocytoma,benign c.250G>C p.V84L 3:10142097-10142097 12
12 COSM88305342 VHL adrenal gland,adrenal gland,pheochromocytoma,benign c.492G>T p.Q164H 3:10149815-10149815 12
13 COSM90653943 VHL adrenal gland,adrenal gland,pheochromocytoma,benign c.352A>G p.K118E 3:10149798-10149798 12
14 COSM90668341 VHL adrenal gland,adrenal gland,pheochromocytoma,benign c.369G>T p.Q123H 3:10149815-10149815 12
15 COSM88292236 VHL adrenal gland,adrenal gland,pheochromocytoma,benign c.491A>G p.Q164R 3:10149814-10149814 12
16 COSM90652730 VHL adrenal gland,adrenal gland,pheochromocytoma,benign c.227T>A p.F76Y 3:10142074-10142074 12
17 COSM90648957 VHL adrenal gland,adrenal gland,pheochromocytoma,benign c.359G>A p.R120Q 3:10149805-10149805 12
18 COSM90664073 VHL adrenal gland,adrenal gland,pheochromocytoma,benign c.341-3225T>G p.? 3:10146562-10146562 12
19 COSM90811579 RET adrenal gland,adrenal gland,pheochromocytoma,benign c.2753T>C p.M918T 10:43121968-43121968 12
20 COSM92347003 RET adrenal gland,adrenal gland,pheochromocytoma,benign c.2753T>C p.M918T 10:43121968-43121968 12
21 COSM142343426 RET adrenal gland,adrenal gland,pheochromocytoma,benign c.1289+3268T>C p.? 10:43114500-43114500 12
22 COSM142343204 RET adrenal gland,adrenal gland,pheochromocytoma,benign c.*102T>C p.? 10:43121968-43121968 12
23 COSM92347226 RET adrenal gland,adrenal gland,pheochromocytoma,benign c.1900T>C p.C634R 10:43114500-43114500 12
24 COSM90811811 RET adrenal gland,adrenal gland,pheochromocytoma,benign c.1900T>C p.C634R 10:43114500-43114500 12
25 COSM93530486 NF1 adrenal gland,adrenal gland,pheochromocytoma,benign c.226G>T p.E76* 17:31159031-31159031 12
26 COSM93656552 NF1 adrenal gland,adrenal gland,pheochromocytoma,benign c.1885G>A p.G629R 17:31225134-31225134 12
27 COSM93692982 NF1 adrenal gland,adrenal gland,pheochromocytoma,benign c.5665G>T p.E1889* 17:31330351-31330351 12
28 COSM93650970 NF1 adrenal gland,adrenal gland,pheochromocytoma,benign c.1466A>G p.Y489C 17:31214524-31214524 12
29 COSM120509060 NF1 adrenal gland,adrenal gland,pheochromocytoma,benign c.1466A>G p.Y489C 17:31214524-31214524 12
30 COSM93535461 NF1 adrenal gland,adrenal gland,pheochromocytoma,benign c.3158C>A p.S1053* 17:31230886-31230886 12
31 COSM109968573 NF1 adrenal gland,adrenal gland,pheochromocytoma,benign c.226G>T p.E76* 17:31159031-31159031 12
32 COSM109960979 NF1 adrenal gland,adrenal gland,pheochromocytoma,benign c.1466A>G p.Y489C 17:31214524-31214524 12
33 COSM93512112 NF1 adrenal gland,adrenal gland,pheochromocytoma,benign c.1885G>A p.G629R 17:31225134-31225134 12
34 COSM93508888 NF1 adrenal gland,adrenal gland,pheochromocytoma,benign c.205-1G>C p.? 17:31159009-31159009 12
35 COSM93509879 NF1 adrenal gland,adrenal gland,pheochromocytoma,benign c.2409+1G>A p.? 17:31227607-31227607 12
36 COSM120509488 NF1 adrenal gland,adrenal gland,pheochromocytoma,benign c.205-1G>C p.? 17:31159009-31159009 12
37 COSM93507010 NF1 adrenal gland,adrenal gland,pheochromocytoma,benign c.7237C>T p.Q2413* 17:31349230-31349230 12
38 COSM93662933 NF1 adrenal gland,adrenal gland,pheochromocytoma,benign c.7582C>T p.Q2528* 17:31352381-31352381 12
39 COSM93654948 NF1 adrenal gland,adrenal gland,pheochromocytoma,benign c.7646C>G p.S2549* 17:31356490-31356490 12
40 COSM93504734 NF1 adrenal gland,adrenal gland,pheochromocytoma,benign c.1721+3A>T p.? 17:31221932-31221932 12
41 COSM93507162 NF1 adrenal gland,adrenal gland,pheochromocytoma,benign c.1466A>G p.Y489C 17:31214524-31214524 12
42 COSM120515658 NF1 adrenal gland,adrenal gland,pheochromocytoma,benign c.226G>T p.E76* 17:31159031-31159031 12
43 COSM93650764 NF1 adrenal gland,adrenal gland,pheochromocytoma,benign c.7300C>T p.Q2434* 17:31349230-31349230 12
44 COSM93517207 NF1 adrenal gland,adrenal gland,pheochromocytoma,benign c.7519C>T p.Q2507* 17:31352381-31352381 12
45 COSM109960306 NF1 adrenal gland,adrenal gland,pheochromocytoma,benign c.1724A>T p.Y575F 17:31221932-31221932 12
46 COSM93652933 NF1 adrenal gland,adrenal gland,pheochromocytoma,benign c.205-1G>C p.? 17:31159009-31159009 12
47 COSM93668028 NF1 adrenal gland,adrenal gland,pheochromocytoma,benign c.1722-1G>A p.? 17:31223443-31223443 12
48 COSM93647950 NF1 adrenal gland,adrenal gland,pheochromocytoma,benign c.1721+3A>T p.? 17:31221932-31221932 12
49 COSM93688082 NF1 adrenal gland,adrenal gland,pheochromocytoma,benign c.6855C>A p.Y2285* 17:31338739-31338739 12
50 COSM109961525 NF1 adrenal gland,adrenal gland,pheochromocytoma,benign c.205-1G>C p.? 17:31159009-31159009 12

Expression for Adrenal Gland Disease

Search GEO for disease gene expression data for Adrenal Gland Disease.

Pathways for Adrenal Gland Disease



Pathways directly related to Adrenal Gland Disease:

# Pathway Source
1 Defective CYP11B1 causes AH4 Reactome 66
2 Defective CYP17A1 causes AH5 Reactome 66
3 Defective CYP21A2 causes AH3 Reactome 66
4 Defective ACTH causes obesity and POMCD Reactome 66

Pathways related to Adrenal Gland Disease according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.22 PRKAR1A KCNJ5 CRH ATP2B3
2
Show member pathways
11.69 REN NR3C2 CYP11B2
3
Show member pathways
11.66 PRKAR1A POMC MC2R CRH
4
Show member pathways
11.57 POMC CYP11B2 CYP11B1
5 11.5 POMC CYP11B1 CRH
6 11.46 SST PRKAR1A NR3C1 MIR210
7 11.38 PRL POMC NR3C1
8 10.1 POMC CRH
9 10.1 PRL POMC INS

GO Terms for Adrenal Gland Disease

Biological processes related to Adrenal Gland Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 C21-steroid hormone biosynthetic process GO:0006700 9.71 CYP11B2 CYP11B1
2 cortisol metabolic process GO:0034650 9.67 CYP11B2 CYP11B1
3 adrenal gland development GO:0030325 9.63 NR3C1 NR0B1 CRH
4 cortisol biosynthetic process GO:0034651 9.62 CYP11B2 CYP11B1
5 aldosterone biosynthetic process GO:0032342 9.56 CYP11B2 CYP11B1
6 cellular response to peptide hormone stimulus GO:0071375 9.43 MEN1 CYP11B2 CYP11B1
7 glucocorticoid biosynthetic process GO:0006704 9.1 CYP11B2 CYP11B1 CRH

Molecular functions related to Adrenal Gland Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 corticosterone 18-monooxygenase activity GO:0047783 9.46 CYP11B2 CYP11B1
2 hormone activity GO:0005179 9.32 SST PRL POMC INS CRH
3 steroid 11-beta-monooxygenase activity GO:0004507 9.26 CYP11B2 CYP11B1

Sources for Adrenal Gland Disease

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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