Adrenal Medulla Cancer disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

Sources

Aliases & Classifications for Adrenal Medulla Cancer

MalaCards integrated aliases for Adrenal Medulla Cancer:

Name: Adrenal Medulla Cancer ¹² ⁵⁴ ¹⁵

Malignant Tumor of the Adrenal Medulla ¹²

Malignant Neoplasm of Adrenal Medulla ¹²

Neoplasm of Adrenal Medulla ⁷⁴

Adrenal Medulla Carcinoma ¹²

Adrenal Medulla Neoplasm ¹²

Adrenal Medulla Tumor ¹²

Classifications:

MalaCards categories:
Global: Rare diseases Cancer diseases
Anatomical: Endocrine diseases

See all MalaCards categories (disease lists)

ICD10: ³⁴

Neoplasms

Malignant neoplasms of thyroid and other endocrine glands

Malignant neoplasm of adrenal gland

Malignant neoplasm: Medulla of adrenal gland

External Ids:

Disease Ontology ¹² DOID:5719 DOID:7379

NCIt ⁵¹ C4396 C4856 C9276

SNOMED-CT ⁶⁹ 93666006

ICD10 ³⁴ C74.1

UMLS ⁷⁴ C0344456 C0596046 C1334717

Sources

Summaries for Adrenal Medulla Cancer

Disease Ontology : ¹² An adrenal gland cancer that is located in the adrenal medulla.

MalaCards based summary : Adrenal Medulla Cancer, also known as malignant tumor of the adrenal medulla, is related to malignant pheochromocytoma and pheochromocytoma. An important gene associated with Adrenal Medulla Cancer is SDHB (Succinate Dehydrogenase Complex Iron Sulfur Subunit B), and among its related pathways/superpathways are Carbon metabolism and Pyruvate metabolism and Citric Acid (TCA) cycle. Affiliated tissues include adrenal gland, lymph node and the adrenal medulla, and related phenotype is cardiovascular system.

Sources

Related Diseases for Adrenal Medulla Cancer

Diseases related to Adrenal Medulla Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 31)

#	Related Disease	Score	Top Affiliating Genes
1	malignant pheochromocytoma	31.7	CHGA PNMT SDHB
2	pheochromocytoma	28.1	CHGA PNMT RET SCG2 SDHAF2 SDHB
3	glomus tumor	10.2	SDHB SDHD
4	carcinoid tumors, intestinal	10.1	CHGA SDHD
5	chondroma	10.1	SDHB SDHC SDHD
6	paraganglioma and gastric stromal sarcoma	10.1	SDHB SDHC SDHD
7	carney triad	10.1	SDHB SDHC SDHD
8	plethora of newborn	10.1	SDHB SDHC SDHD
9	lymphatic system disease	10.0	SDHB SDHC SDHD
10	intracranial primitive neuroectodermal tumor	10.0	CHGA SCG2
11	multiple endocrine neoplasia, type iia	10.0	RET SDHB SDHD
12	autosomal genetic disease	10.0	RET SDHB SDHD
13	ganglioneuroma	10.0	CHGA RET
14	collagenous colitis	10.0	CHGA SCG2
15	adrenal gland pheochromocytoma	9.9
16	sporadic pheochromocytoma	9.9	RET SDHB SDHC SDHD
17	neurofibromatosis, type iv, of riccardi	9.9	RET SDHB SDHC SDHD
18	multiple endocrine neoplasia, type i	9.9	CHGA RET SDHB SDHD
19	gastrointestinal stromal tumor	9.9	CHGA SDHB SDHC SDHD
20	neural crest tumor	9.9	SDHAF2 SDHB SDHC SDHD
21	persistent generalized lymphadenopathy	9.9	SDHAF2 SDHB SDHC SDHD
22	parathyroid adenoma	9.9	CHGA RET
23	lymph node disease	9.9	SDHAF2 SDHB SDHC SDHD
24	mitochondrial complex ii deficiency	9.9	SDHAF2 SDHB SDHC SDHD
25	paragangliomas 1	9.7	CHGA RET SDHB SDHC SDHD
26	hereditary paraganglioma-pheochromocytoma syndromes	9.7	RET SDHAF2 SDHB SDHC SDHD
27	multiple endocrine neoplasia	9.5	CHGA PNMT RET SDHB SDHC
28	extra-adrenal pheochromocytoma	9.5	PNMT SDHAF2 SDHB SDHC SDHD
29	endocrine organ benign neoplasm	9.5	CHGA RET SDHAF2 SDHB SDHC SDHD
30	paraganglioma	9.5	CHGA RET SDHAF2 SDHB SDHC SDHD
31	von hippel-lindau syndrome	9.4	CHGA PNMT RET SDHB SDHC SDHD

Graphical network of the top 20 diseases related to Adrenal Medulla Cancer:

Sources

Symptoms & Phenotypes for Adrenal Medulla Cancer

MGI Mouse Phenotypes related to Adrenal Medulla Cancer:

⁴⁷

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	cardiovascular system	MP:0005385	9.02	CHGA PNMT RET SCG2 SDHD

Sources

Drugs & Therapeutics for Adrenal Medulla Cancer

Search Clinical Trials , NIH Clinical Center for Adrenal Medulla Cancer

Sources

Genetic Tests for Adrenal Medulla Cancer

Sources

Anatomical Context for Adrenal Medulla Cancer

MalaCards organs/tissues related to Adrenal Medulla Cancer:

⁴²

Adrenal Gland, Lymph Node

The Foundational Model of Anatomy Ontology organs/tissues related to Adrenal Medulla Cancer:

²⁰

The Adrenal Medulla

Sources

Publications for Adrenal Medulla Cancer

Articles related to Adrenal Medulla Cancer:

#	Title	Authors	Year
1	Inhibition of Cdc42 and Rac1 activities in pheochromocytoma, the adrenal medulla tumor. ( 27355516 )	Crois? P...Ory S	2017

Sources

Genes for Adrenal Medulla Cancer

Genes related to Adrenal Medulla Cancer (0 elite genes):

(show all 11)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	SDHB	Succinate Dehydrogenase Complex Iron Sulfur Subunit B	Protein Coding	17.21	DISEASES inferred ¹⁵
2	SDHD	Succinate Dehydrogenase Complex Subunit D	Protein Coding	16.68	DISEASES inferred ¹⁵
3	SDHC	Succinate Dehydrogenase Complex Subunit C	Protein Coding	16.08	DISEASES inferred ¹⁵
4	CHGA	Chromogranin A	Protein Coding	15.67	DISEASES inferred ¹⁵
5	RET	Ret Proto-Oncogene	Protein Coding	15.64	DISEASES inferred ¹⁵
6	BMS1	BMS1 Ribosome Biogenesis Factor	Protein Coding	15.39	DISEASES inferred ¹⁵
7	SDHAF2	Succinate Dehydrogenase Complex Assembly Factor 2	Protein Coding	15.12	DISEASES inferred ¹⁵
8	SCG2	Secretogranin II	Protein Coding	14.94	DISEASES inferred ¹⁵
9	PNMT	Phenylethanolamine N-Methyltransferase	Protein Coding	14.89	DISEASES inferred ¹⁵
10	TGDS	TDP-Glucose 4,6-Dehydratase	Protein Coding	14.82	DISEASES inferred ¹⁵
11	ZNF367	Zinc Finger Protein 367	Protein Coding	5.58	DISEASES inferred ¹⁵

Sources

Variations for Adrenal Medulla Cancer

Sources

Expression for Adrenal Medulla Cancer

Search GEO for disease gene expression data for Adrenal Medulla Cancer.

Sources

Pathways for Adrenal Medulla Cancer

Pathways related to Adrenal Medulla Cancer according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Carbon metabolism ³⁸ Show member pathways 2-Oxocarboxylic acid metabolism ³⁸ Biosynthesis of amino acids ³⁸ formaldehyde oxidation ¹	11.66	SDHB SDHC SDHD
2	Pyruvate metabolism and Citric Acid (TCA) cycle ⁶⁷ Show member pathways Citric acid cycle (TCA cycle) ⁶⁷ Interconversion of 2-oxoglutarate and 2-hydroxyglutarate ⁶⁷ NAD phosphorylation and dephosphorylation ¹ Pyruvate metabolism ⁶⁷ Regulation of pyruvate dehydrogenase (PDH) complex ⁶⁷ TCA Cycle ¹	11.25	SDHB SDHC SDHD
3	Citrate cycle (TCA cycle) ³⁸ Show member pathways pyruvate decarboxylation to acetyl CoA ¹ superpathway of conversion of glucose to acetyl CoA and entry into the TCA cycle ¹ TCA cycle ¹ TCA Cycle and Deficiency of Pyruvate Dehydrogenase complex (PDHc) ¹	10.81	SDHB SDHC SDHD

Sources

GO Terms for Adrenal Medulla Cancer

Cellular components related to Adrenal Medulla Cancer according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	respiratory chain complex II	GO:0045273	8.96	SDHB SDHC
2	mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)	GO:0005749	8.8	SDHB SDHC SDHD

Biological processes related to Adrenal Medulla Cancer according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	aerobic respiration	GO:0009060	9.16	SDHB SDHC
2	mitochondrial electron transport, succinate to ubiquinone	GO:0006121	9.13	SDHAF2 SDHC SDHD
3	tricarboxylic acid cycle	GO:0006099	8.92	SDHD SDHC SDHAF2 SDHB

Molecular functions related to Adrenal Medulla Cancer according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	electron transfer activity	GO:0009055	9.33	SDHB SDHC SDHD
2	ubiquinone binding	GO:0048039	8.96	SDHB SDHD
3	succinate dehydrogenase (ubiquinone) activity	GO:0008177	8.8	SDHB SDHC SDHD

Sources

Sources for Adrenal Medulla Cancer

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ EFO

¹⁸ ExPASy

¹⁹ FDA Approved Drugs

²⁰ FMA

²¹ GeneAnalytics

²² GeneCards

²³ GeneGo (Thomson Reuters)

²⁴ GeneHancer via GeneCards

²⁵ GeneReviews

²⁶ Genetics Home Reference

²⁷ GenomeRNAi

²⁸ GEO DataSets

²⁹ GO

³⁰ GTR

³¹ HGMD

³² HMDB

³³ HPO

³⁴ ICD10

³⁵ ICD10 via Orphanet

³⁶ ICD9CM

³⁷ IUPHAR

³⁸ KEGG

³⁹ LifeMap

⁴⁰ LncRNADisease

⁴¹ LOVD

⁴² MalaCards

⁴³ MedGen

⁴⁴ MedlinePlus

⁴⁵ MeSH

⁴⁶ MESH via Orphanet

⁴⁷ MGI

⁴⁸ miR2Disease

⁴⁹ NCBI Bookshelf

⁵⁰ NCI

⁵¹ NCIt

⁵² NDF-RT

⁵³ NIH Clinical Center

⁵⁴ NIH Rare Diseases

⁵⁵ NINDS

⁵⁶ Novoseek

⁵⁷ Novus Biologicals

⁵⁸ OMIM

⁵⁹ OMIM via Orphanet

⁶⁰ Orphanet

⁶¹ PathCards

⁶² PharmGKB

⁶³ PubMed

⁶⁴ PubMed Health

⁶⁵ QIAGEN

⁶⁶ R&D Systems

⁶⁷ Reactome

⁶⁸ Sino Biological

⁶⁹ SNOMED-CT

⁷⁰ SNOMED-CT via HPO

⁷¹ SNOMED-CT via Orphanet

⁷² TGDB

⁷³ Tocris

⁷⁴ UMLS

⁷⁵ UMLS via Orphanet

⁷⁶ UniProtKB/Swiss-Prot

⁷⁷ Wikipedia