MCID: ADR014
MIFTS: 29

Adrenal Medulla Cancer

Categories: Cancer diseases, Endocrine diseases, Rare diseases

Aliases & Classifications for Adrenal Medulla Cancer

MalaCards integrated aliases for Adrenal Medulla Cancer:

Name: Adrenal Medulla Cancer 12 53 15
Malignant Tumor of the Adrenal Medulla 12
Malignant Neoplasm of Adrenal Medulla 12
Neoplasm of Adrenal Medulla 72
Adrenal Medulla Carcinoma 12
Adrenal Medulla Neoplasm 12
Adrenal Medulla Tumor 12

Classifications:



External Ids:

Disease Ontology 12 DOID:5719 DOID:7379
SNOMED-CT 68 93666006
ICD10 33 C74.1
UMLS 72 C0344456 C0596046 C1334717

Summaries for Adrenal Medulla Cancer

Disease Ontology : 12 An adrenal gland cancer that is located in the adrenal medulla.

MalaCards based summary : Adrenal Medulla Cancer, also known as malignant tumor of the adrenal medulla, is related to malignant pheochromocytoma and pheochromocytoma. An important gene associated with Adrenal Medulla Cancer is SDHB (Succinate Dehydrogenase Complex Iron Sulfur Subunit B), and among its related pathways/superpathways are Carbon metabolism and Pyruvate metabolism and Citric Acid (TCA) cycle. Affiliated tissues include adrenal gland, thyroid and lung, and related phenotypes are cardiovascular system and homeostasis/metabolism

Related Diseases for Adrenal Medulla Cancer

Diseases related to Adrenal Medulla Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 41)
# Related Disease Score Top Affiliating Genes
1 malignant pheochromocytoma 31.7 SDHB PNMT CHGA
2 pheochromocytoma 25.5 TMEM127 SDHD SDHC SDHB SDHAF2 SDHA
3 glomus tumor 10.4 SDHD SDHB
4 intracranial primitive neuroectodermal tumor 10.4 SCG2 CHGA
5 carcinoid tumors, intestinal 10.4 SDHD CHGA
6 epithelioid malignant peripheral nerve sheath tumor 10.3 NF1 CHGA
7 autonomic nervous system benign neoplasm 10.3 NF1 CHGA
8 chondroma 10.3 SDHD SDHC SDHB
9 paraganglioma and gastric stromal sarcoma 10.3 SDHD SDHC SDHB
10 plethora of newborn 10.3 SDHD SDHC SDHB
11 collagenous colitis 10.2 SCG2 CHGA
12 spinal canal and spinal cord meningioma 10.2 NF1 CHGA
13 endodermal sinus tumor 10.2 CHGA CGB3
14 seminal vesicle tumor 10.2 SDHB SDHA
15 spinal meningioma 10.2 NF1 CHGA
16 adrenal gland pheochromocytoma 10.1
17 spastic quadriplegia 10.1 SDHD SDHA
18 quadriplegia 10.1 SDHD SDHA
19 ganglioneuroma 10.0 RET CHGA
20 multiple endocrine neoplasia, type i 10.0 SDHD SDHB RET CHGA
21 lymphatic system disease 10.0 TMEM127 SDHD SDHC SDHB
22 mixed ductal-endocrine carcinoma 9.9 CHGA CGB3
23 generalized epilepsy with febrile seizures plus 9.9
24 multiple endocrine neoplasia, type iia 9.9 SDHD SDHB RET NF1
25 autosomal genetic disease 9.9 SDHD SDHB RET NF1
26 carney triad 9.7 SDHD SDHC SDHB SDHA
27 paragangliomas 1 9.7 SDHD SDHC SDHB RET CHGA
28 serotonin syndrome 9.7 CHGA CGB3
29 sporadic pheochromocytoma 9.6 SDHD SDHC SDHB RET NF1
30 neurofibromatosis, type iv, of riccardi 9.6 SDHD SDHC SDHB RET NF1
31 neural crest tumor 9.3 SDHD SDHC SDHB SDHAF2 SDHA
32 mitochondrial complex ii deficiency 9.3 SDHD SDHC SDHB SDHAF2 SDHA
33 extra-adrenal pheochromocytoma 9.1 SDHD SDHC SDHB SDHAF2 PNMT
34 gastrointestinal stromal tumor 9.1 SDHD SDHC SDHB SDHA NF1 CHGA
35 persistent generalized lymphadenopathy 8.9 TMEM127 SDHD SDHC SDHB SDHAF2 SDHA
36 lymph node disease 8.9 TMEM127 SDHD SDHC SDHB SDHAF2 SDHA
37 multiple endocrine neoplasia 8.8 SDHC SDHB RET PNMT NF1 CHGA
38 hereditary paraganglioma-pheochromocytoma syndromes 8.6 TMEM127 SDHD SDHC SDHB SDHAF2 SDHA
39 von hippel-lindau syndrome 8.6 SDHD SDHC SDHB RET PNMT NF1
40 endocrine organ benign neoplasm 8.3 TMEM127 SDHD SDHC SDHB SDHAF2 SDHA
41 paraganglioma 7.9 TMEM127 SDHD SDHC SDHB SDHAF2 SDHA

Graphical network of the top 20 diseases related to Adrenal Medulla Cancer:



Diseases related to Adrenal Medulla Cancer

Symptoms & Phenotypes for Adrenal Medulla Cancer

MGI Mouse Phenotypes related to Adrenal Medulla Cancer:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.43 CHGA NF1 PNMT RET SCG2 SDHD
2 homeostasis/metabolism MP:0005376 9.28 CHGA NF1 PNMT RET SDHA SDHB

Drugs & Therapeutics for Adrenal Medulla Cancer

Search Clinical Trials , NIH Clinical Center for Adrenal Medulla Cancer

Genetic Tests for Adrenal Medulla Cancer

Anatomical Context for Adrenal Medulla Cancer

MalaCards organs/tissues related to Adrenal Medulla Cancer:

41
Adrenal Gland, Thyroid, Lung, Cerebellum

The Foundational Model of Anatomy Ontology organs/tissues related to Adrenal Medulla Cancer:

19
Adrenal Medulla

Publications for Adrenal Medulla Cancer

Articles related to Adrenal Medulla Cancer:

# Title Authors PMID Year
1
Lycium europaeum fruit extract: antiproliferative activity on A549 human lung carcinoma cells and PC12 rat adrenal medulla cancer cells and assessment of its cytotoxicity on cerebellum granule cells. 38
25825796 2015

Variations for Adrenal Medulla Cancer

Expression for Adrenal Medulla Cancer

Search GEO for disease gene expression data for Adrenal Medulla Cancer.

Pathways for Adrenal Medulla Cancer

GO Terms for Adrenal Medulla Cancer

Cellular components related to Adrenal Medulla Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 mitochondrial inner membrane GO:0005743 9.46 SDHD SDHC SDHB SDHA
2 respiratory chain complex II GO:0045273 8.96 SDHC SDHB
3 mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone) GO:0005749 8.92 SDHD SDHC SDHB SDHA

Biological processes related to Adrenal Medulla Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 MAPK cascade GO:0000165 9.63 SCG2 RET NF1
2 electron transport chain GO:0022900 9.5 SDHC SDHB SDHA
3 negative regulation of endothelial cell proliferation GO:0001937 9.43 SCG2 NF1
4 aerobic respiration GO:0009060 9.4 SDHC SDHB
5 respiratory electron transport chain GO:0022904 9.37 SDHB SDHA
6 tricarboxylic acid cycle GO:0006099 9.35 SDHD SDHC SDHB SDHAF2 SDHA
7 positive regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001241 9.26 RET NF1
8 succinate metabolic process GO:0006105 9.16 SDHB SDHA
9 mitochondrial electron transport, succinate to ubiquinone GO:0006121 8.92 SDHD SDHC SDHAF2 SDHA

Molecular functions related to Adrenal Medulla Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 electron transfer activity GO:0009055 9.46 SDHD SDHC SDHB SDHA
2 oxidoreductase activity, acting on the CH-CH group of donors GO:0016627 9.32 SDHC SDHA
3 succinate dehydrogenase activity GO:0000104 9.26 SDHD SDHA
4 ubiquinone binding GO:0048039 8.96 SDHD SDHB
5 succinate dehydrogenase (ubiquinone) activity GO:0008177 8.92 SDHD SDHC SDHB SDHA

Sources for Adrenal Medulla Cancer

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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