MCID: ADR014
MIFTS: 29

Adrenal Medulla Cancer

Categories: Cancer diseases, Endocrine diseases, Rare diseases

Aliases & Classifications for Adrenal Medulla Cancer

MalaCards integrated aliases for Adrenal Medulla Cancer:

Name: Adrenal Medulla Cancer 12 54 15
Malignant Tumor of the Adrenal Medulla 12
Malignant Neoplasm of Adrenal Medulla 12
Neoplasm of Adrenal Medulla 74
Adrenal Medulla Carcinoma 12
Adrenal Medulla Neoplasm 12
Adrenal Medulla Tumor 12

Classifications:



External Ids:

Disease Ontology 12 DOID:5719 DOID:7379
SNOMED-CT 69 93666006
ICD10 34 C74.1

Summaries for Adrenal Medulla Cancer

Disease Ontology : 12 An adrenal gland cancer that is located in the adrenal medulla.

MalaCards based summary : Adrenal Medulla Cancer, also known as malignant tumor of the adrenal medulla, is related to malignant pheochromocytoma and pheochromocytoma. An important gene associated with Adrenal Medulla Cancer is SDHB (Succinate Dehydrogenase Complex Iron Sulfur Subunit B), and among its related pathways/superpathways are Carbon metabolism and Pyruvate metabolism and Citric Acid (TCA) cycle. Affiliated tissues include adrenal gland, lymph node and the adrenal medulla, and related phenotype is cardiovascular system.

Related Diseases for Adrenal Medulla Cancer

Diseases related to Adrenal Medulla Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 31)
# Related Disease Score Top Affiliating Genes
1 malignant pheochromocytoma 31.7 CHGA PNMT SDHB
2 pheochromocytoma 28.1 CHGA PNMT RET SCG2 SDHAF2 SDHB
3 glomus tumor 10.2 SDHB SDHD
4 carcinoid tumors, intestinal 10.1 CHGA SDHD
5 chondroma 10.1 SDHB SDHC SDHD
6 paraganglioma and gastric stromal sarcoma 10.1 SDHB SDHC SDHD
7 carney triad 10.1 SDHB SDHC SDHD
8 plethora of newborn 10.1 SDHB SDHC SDHD
9 lymphatic system disease 10.0 SDHB SDHC SDHD
10 intracranial primitive neuroectodermal tumor 10.0 CHGA SCG2
11 multiple endocrine neoplasia, type iia 10.0 RET SDHB SDHD
12 autosomal genetic disease 10.0 RET SDHB SDHD
13 ganglioneuroma 10.0 CHGA RET
14 collagenous colitis 10.0 CHGA SCG2
15 adrenal gland pheochromocytoma 9.9
16 sporadic pheochromocytoma 9.9 RET SDHB SDHC SDHD
17 neurofibromatosis, type iv, of riccardi 9.9 RET SDHB SDHC SDHD
18 multiple endocrine neoplasia, type i 9.9 CHGA RET SDHB SDHD
19 gastrointestinal stromal tumor 9.9 CHGA SDHB SDHC SDHD
20 neural crest tumor 9.9 SDHAF2 SDHB SDHC SDHD
21 persistent generalized lymphadenopathy 9.9 SDHAF2 SDHB SDHC SDHD
22 parathyroid adenoma 9.9 CHGA RET
23 lymph node disease 9.9 SDHAF2 SDHB SDHC SDHD
24 mitochondrial complex ii deficiency 9.9 SDHAF2 SDHB SDHC SDHD
25 paragangliomas 1 9.7 CHGA RET SDHB SDHC SDHD
26 hereditary paraganglioma-pheochromocytoma syndromes 9.7 RET SDHAF2 SDHB SDHC SDHD
27 multiple endocrine neoplasia 9.5 CHGA PNMT RET SDHB SDHC
28 extra-adrenal pheochromocytoma 9.5 PNMT SDHAF2 SDHB SDHC SDHD
29 endocrine organ benign neoplasm 9.5 CHGA RET SDHAF2 SDHB SDHC SDHD
30 paraganglioma 9.5 CHGA RET SDHAF2 SDHB SDHC SDHD
31 von hippel-lindau syndrome 9.4 CHGA PNMT RET SDHB SDHC SDHD

Graphical network of the top 20 diseases related to Adrenal Medulla Cancer:



Diseases related to Adrenal Medulla Cancer

Symptoms & Phenotypes for Adrenal Medulla Cancer

MGI Mouse Phenotypes related to Adrenal Medulla Cancer:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.02 CHGA PNMT RET SCG2 SDHD

Drugs & Therapeutics for Adrenal Medulla Cancer

Search Clinical Trials , NIH Clinical Center for Adrenal Medulla Cancer

Genetic Tests for Adrenal Medulla Cancer

Anatomical Context for Adrenal Medulla Cancer

MalaCards organs/tissues related to Adrenal Medulla Cancer:

42
Adrenal Gland, Lymph Node

The Foundational Model of Anatomy Ontology organs/tissues related to Adrenal Medulla Cancer:

20
The Adrenal Medulla

Publications for Adrenal Medulla Cancer

Articles related to Adrenal Medulla Cancer:

# Title Authors Year
1
Inhibition of Cdc42 and Rac1 activities in pheochromocytoma, the adrenal medulla tumor. ( 27355516 )
2017

Variations for Adrenal Medulla Cancer

Expression for Adrenal Medulla Cancer

Search GEO for disease gene expression data for Adrenal Medulla Cancer.

Pathways for Adrenal Medulla Cancer

GO Terms for Adrenal Medulla Cancer

Cellular components related to Adrenal Medulla Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 respiratory chain complex II GO:0045273 8.96 SDHB SDHC
2 mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone) GO:0005749 8.8 SDHB SDHC SDHD

Biological processes related to Adrenal Medulla Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 aerobic respiration GO:0009060 9.16 SDHB SDHC
2 mitochondrial electron transport, succinate to ubiquinone GO:0006121 9.13 SDHAF2 SDHC SDHD
3 tricarboxylic acid cycle GO:0006099 8.92 SDHD SDHC SDHAF2 SDHB

Molecular functions related to Adrenal Medulla Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 electron transfer activity GO:0009055 9.33 SDHB SDHC SDHD
2 ubiquinone binding GO:0048039 8.96 SDHB SDHD
3 succinate dehydrogenase (ubiquinone) activity GO:0008177 8.8 SDHB SDHC SDHD

Sources for Adrenal Medulla Cancer

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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