MCID: ADR014
MIFTS: 29

Adrenal Medulla Cancer

Categories: Cancer diseases, Endocrine diseases, Rare diseases

Aliases & Classifications for Adrenal Medulla Cancer

MalaCards integrated aliases for Adrenal Medulla Cancer:

Name: Adrenal Medulla Cancer 12 52 15
Malignant Tumor of the Adrenal Medulla 12
Malignant Neoplasm of Adrenal Medulla 12
Neoplasm of Adrenal Medulla 71
Adrenal Medulla Carcinoma 12
Adrenal Medulla Neoplasm 12
Adrenal Medulla Tumor 12

Classifications:



External Ids:

Disease Ontology 12 DOID:5719 DOID:7379
SNOMED-CT 67 93666006
ICD10 32 C74.1
UMLS 71 C0344456 C0596046 C1334717

Summaries for Adrenal Medulla Cancer

Disease Ontology : 12 An adrenal gland cancer that is located in the adrenal medulla.

MalaCards based summary : Adrenal Medulla Cancer, also known as malignant tumor of the adrenal medulla, is related to malignant pheochromocytoma and pheochromocytoma. An important gene associated with Adrenal Medulla Cancer is MIR483 (MicroRNA 483), and among its related pathways/superpathways are Pyruvate metabolism and Citric Acid (TCA) cycle and Carbon metabolism. Affiliated tissues include adrenal medulla, adrenal gland and thyroid, and related phenotype is homeostasis/metabolism.

Related Diseases for Adrenal Medulla Cancer

Diseases related to Adrenal Medulla Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 172)
# Related Disease Score Top Affiliating Genes
1 malignant pheochromocytoma 29.9 SYP SST SLC6A2 SDHB PNMT MIR483
2 pheochromocytoma 25.4 TMEM127 SYP SST SLC6A2 SDHD SDHC
3 neurofibromatosis, type i 10.5 SDHD NF1
4 plethora of newborn 10.5 SDHD PGLS
5 multiple mucosal neuroma 10.5 RET PGLS
6 central nervous system hemangioma 10.4 RET NF1
7 skin lipoma 10.4 RET NF1
8 extracranial neuroblastoma 10.4 SDHD SDHB CHGA
9 ureter small cell carcinoma 10.4 SYP CHGA
10 primary hepatic neuroendocrine carcinoma 10.4 SYP CHGA
11 ovarian large-cell neuroendocrine carcinoma 10.4 SYP CHGA
12 pancreas lymphoma 10.4 SYP CHGA
13 leiomyoma cutis 10.4 SDHD SDHA
14 small cell carcinoma of the bladder 10.4 SYP CHGA
15 acinar cell cystadenocarcinoma 10.4 SYP CHGA
16 vulvar eccrine porocarcinoma 10.4 SYP CHGA
17 urinary bladder small cell neuroendocrine carcinoma 10.4 SYP CHGA
18 epithelioid malignant peripheral nerve sheath tumor 10.4 NF1 CHGA
19 paraganglioma and gastric stromal sarcoma 10.4 SDHD SDHC SDHB
20 appendix carcinoid tumor 10.4 SYP CHGA
21 auditory system cancer 10.4 SYP CHGA
22 mixed ductal-endocrine carcinoma 10.4 SYP CHGA
23 thymus small cell carcinoma 10.4 SYP CHGA
24 papillary thymic adenocarcinoma 10.4 SYP CHGA
25 breast papillary carcinoma 10.4 SYP CHGA
26 cauda equina neoplasm 10.3 SYP CHGA
27 hypoganglionosis 10.3 SYP RET
28 vaginal tubulovillous adenoma 10.3 SYP CHGA
29 multiple endocrine neoplasia 10.3 SDHC SDHB RET
30 vaginal adenoma 10.3 SYP CHGA
31 middle ear adenoma 10.3 SYP CHGA
32 nodular ganglioneuroblastoma 10.3 SYP CHGA
33 esophageal adenoid cystic carcinoma 10.3 SYP CHGA
34 gastric small cell carcinoma 10.3 SYP CHGA
35 vaginal benign neoplasm 10.3 SYP CHGA
36 sensory organ benign neoplasm 10.3 SYP CHGA
37 cervical neuroblastoma 10.3 SYP CHGA
38 subependymoma 10.3 SYP CHGA
39 pineocytoma 10.3 SYP CHGA
40 pulmonary large cell neuroendocrine carcinoma 10.3 SYP CHGA
41 lung oat cell carcinoma 10.3 SYP CHGA
42 cutaneous ganglioneuroma 10.3 SYP CHGA
43 optic nerve astrocytoma 10.3 SYP NF1
44 ovarian germ cell teratoma 10.3 SYP RET
45 laryngeal small cell carcinoma 10.3 SYP CHGA
46 endometrial small cell carcinoma 10.3 SYP CHGA
47 cervix small cell carcinoma 10.3 SYP CHGA
48 esophageal neuroendocrine tumor 10.3 SYP CHGA
49 lung clear cell carcinoma 10.3 SYP CHGA
50 gallbladder small cell carcinoma 10.3 SYP CHGA

Graphical network of the top 20 diseases related to Adrenal Medulla Cancer:



Diseases related to Adrenal Medulla Cancer

Symptoms & Phenotypes for Adrenal Medulla Cancer

MGI Mouse Phenotypes related to Adrenal Medulla Cancer:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.4 CHGA NF1 PNMT RET SDHA SDHB

Drugs & Therapeutics for Adrenal Medulla Cancer

Search Clinical Trials , NIH Clinical Center for Adrenal Medulla Cancer

Genetic Tests for Adrenal Medulla Cancer

Anatomical Context for Adrenal Medulla Cancer

The Foundational Model of Anatomy Ontology organs/tissues related to Adrenal Medulla Cancer:

19
Adrenal Medulla

MalaCards organs/tissues related to Adrenal Medulla Cancer:

40
Adrenal Gland, Thyroid, Lung, Cerebellum, Breast, Appendix, Lymph Node

Publications for Adrenal Medulla Cancer

Articles related to Adrenal Medulla Cancer:

# Title Authors PMID Year
1
Lycium europaeum fruit extract: antiproliferative activity on A549 human lung carcinoma cells and PC12 rat adrenal medulla cancer cells and assessment of its cytotoxicity on cerebellum granule cells. 61
25825796 2015

Variations for Adrenal Medulla Cancer

Expression for Adrenal Medulla Cancer

Search GEO for disease gene expression data for Adrenal Medulla Cancer.

Pathways for Adrenal Medulla Cancer

GO Terms for Adrenal Medulla Cancer

Cellular components related to Adrenal Medulla Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 respiratory chain complex II GO:0045273 8.96 SDHC SDHB
2 mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone) GO:0005749 8.92 SDHD SDHC SDHB SDHA

Biological processes related to Adrenal Medulla Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 electron transport chain GO:0022900 9.5 SDHC SDHB SDHA
2 regulation of long-term neuronal synaptic plasticity GO:0048169 9.43 SYP NF1
3 response to pain GO:0048265 9.4 SLC6A2 RET
4 respiratory electron transport chain GO:0022904 9.37 SDHB SDHA
5 tricarboxylic acid cycle GO:0006099 9.35 SDHD SDHC SDHB SDHAF2 SDHA
6 positive regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001241 9.26 RET NF1
7 succinate metabolic process GO:0006105 9.16 SDHB SDHA
8 mitochondrial electron transport, succinate to ubiquinone GO:0006121 8.92 SDHD SDHC SDHAF2 SDHA

Molecular functions related to Adrenal Medulla Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 electron transfer activity GO:0009055 9.46 SDHD SDHC SDHB SDHA
2 ubiquinone binding GO:0048039 9.26 SDHD SDHB
3 succinate dehydrogenase (ubiquinone) activity GO:0008177 9.13 SDHD SDHB SDHA
4 succinate dehydrogenase activity GO:0000104 8.8 SDHD SDHC SDHA

Sources for Adrenal Medulla Cancer

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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