MCID: ADR014
MIFTS: 30

Adrenal Medulla Cancer

Categories: Rare diseases, Cancer diseases, Endocrine diseases

Aliases & Classifications for Adrenal Medulla Cancer

MalaCards integrated aliases for Adrenal Medulla Cancer:

Name: Adrenal Medulla Cancer 12 53 15
Malignant Tumor of the Adrenal Medulla 12
Malignant Neoplasm of Adrenal Medulla 12
Neoplasm of Adrenal Medulla 73
Adrenal Medulla Carcinoma 12
Adrenal Medulla Neoplasm 12
Adrenal Medulla Tumor 12

Classifications:



External Ids:

Disease Ontology 12 DOID:5719 DOID:7379
ICD10 33 C74.1

Summaries for Adrenal Medulla Cancer

Disease Ontology : 12 An adrenal gland cancer that is located in the adrenal medulla.

MalaCards based summary : Adrenal Medulla Cancer, also known as malignant tumor of the adrenal medulla, is related to extra-adrenal pheochromocytoma and pheochromocytoma. An important gene associated with Adrenal Medulla Cancer is SDHB (Succinate Dehydrogenase Complex Iron Sulfur Subunit B), and among its related pathways/superpathways are Carbon metabolism and Pyruvate metabolism and Citric Acid (TCA) cycle. Affiliated tissues include the adrenal medulla and adrenal gland, and related phenotypes are Decreased viability and Decreased viability

Related Diseases for Adrenal Medulla Cancer

Graphical network of the top 20 diseases related to Adrenal Medulla Cancer:



Diseases related to Adrenal Medulla Cancer

Symptoms & Phenotypes for Adrenal Medulla Cancer

GenomeRNAi Phenotypes related to Adrenal Medulla Cancer according to GeneCards Suite gene sharing:

26 (show all 15)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00107-A-1 10.56 DGKH
2 Decreased viability GR00221-A-1 10.56 DGKH SDHD RET
3 Decreased viability GR00221-A-2 10.56 DGKH SDHD RET
4 Decreased viability GR00221-A-3 10.56 DGKH
5 Decreased viability GR00221-A-4 10.56 DGKH SDHD RET
6 Decreased viability GR00231-A 10.56 RET
7 Decreased viability GR00301-A 10.56 RET
8 Decreased viability GR00381-A-1 10.56 SDHD
9 Decreased viability GR00402-S-2 10.56 DGKH SDHD RET
10 Increased shRNA abundance (Z-score > 2) GR00366-A-132 9.17 SDHC
11 Increased shRNA abundance (Z-score > 2) GR00366-A-188 9.17 SDHC SDHD
12 Increased shRNA abundance (Z-score > 2) GR00366-A-197 9.17 SDHC
13 Increased shRNA abundance (Z-score > 2) GR00366-A-63 9.17 SDHC
14 Increased shRNA abundance (Z-score > 2) GR00366-A-81 9.17 SDHC SDHD
15 Increased mitotic index GR00110-A-0 8.96 RET SDHD

Drugs & Therapeutics for Adrenal Medulla Cancer

Search Clinical Trials , NIH Clinical Center for Adrenal Medulla Cancer

Genetic Tests for Adrenal Medulla Cancer

Anatomical Context for Adrenal Medulla Cancer

The Foundational Model of Anatomy Ontology organs/tissues related to Adrenal Medulla Cancer:

19
The Adrenal Medulla

MalaCards organs/tissues related to Adrenal Medulla Cancer:

41
Adrenal Gland

Publications for Adrenal Medulla Cancer

Articles related to Adrenal Medulla Cancer:

# Title Authors Year
1
[Problems posed by asymptomatic pheochromocytoma and malignant tumors of the adrenal medulla]. ( 8712755 )
1996

Variations for Adrenal Medulla Cancer

Expression for Adrenal Medulla Cancer

Search GEO for disease gene expression data for Adrenal Medulla Cancer.

Pathways for Adrenal Medulla Cancer

GO Terms for Adrenal Medulla Cancer

Cellular components related to Adrenal Medulla Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 mitochondrial inner membrane GO:0005743 9.33 SDHB SDHC SDHD
2 respiratory chain complex II GO:0045273 8.96 SDHB SDHC
3 mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone) GO:0005749 8.8 SDHB SDHC SDHD

Biological processes related to Adrenal Medulla Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 electron transport chain GO:0022900 9.26 SDHB SDHC
2 aerobic respiration GO:0009060 9.16 SDHB SDHC
3 mitochondrial electron transport, succinate to ubiquinone GO:0006121 9.13 SDHAF2 SDHC SDHD
4 tricarboxylic acid cycle GO:0006099 8.92 SDHAF2 SDHB SDHC SDHD

Molecular functions related to Adrenal Medulla Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 electron transfer activity GO:0009055 9.33 SDHB SDHC SDHD
2 ubiquinone binding GO:0048039 9.26 SDHB SDHD
3 succinate dehydrogenase activity GO:0000104 8.96 SDHC SDHD
4 succinate dehydrogenase (ubiquinone) activity GO:0008177 8.8 SDHB SDHC SDHD

Sources for Adrenal Medulla Cancer

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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