MCID: ADR014
MIFTS: 28

Adrenal Medulla Cancer

Categories: Cancer diseases, Endocrine diseases, Rare diseases

Aliases & Classifications for Adrenal Medulla Cancer

MalaCards integrated aliases for Adrenal Medulla Cancer:

Name: Adrenal Medulla Cancer 12 20 15
Malignant Tumor of the Adrenal Medulla 12
Malignant Neoplasm of Adrenal Medulla 12
Neoplasm of Adrenal Medulla 71
Adrenal Medulla Carcinoma 12
Adrenal Medulla Neoplasm 12
Adrenal Medulla Tumor 12

Classifications:



External Ids:

Disease Ontology 12 DOID:5719 DOID:7379
SNOMED-CT 67 127023007 93666006
ICD10 32 C74.1
UMLS 71 C0344456 C0596046 C1334717

Summaries for Adrenal Medulla Cancer

Disease Ontology : 12 An adrenal gland cancer that is located in the adrenal medulla.

MalaCards based summary : Adrenal Medulla Cancer, also known as malignant tumor of the adrenal medulla, is related to malignant pheochromocytoma and pheochromocytoma. An important gene associated with Adrenal Medulla Cancer is MIR483 (MicroRNA 483), and among its related pathways/superpathways are Carbon metabolism and Pyruvate metabolism and Citric Acid (TCA) cycle. Affiliated tissues include adrenal medulla, adrenal gland and thyroid, and related phenotype is homeostasis/metabolism.

Related Diseases for Adrenal Medulla Cancer

Diseases related to Adrenal Medulla Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 184)
# Related Disease Score Top Affiliating Genes
1 malignant pheochromocytoma 30.7 SYP SST SLC6A2 SDHB PNMT MIR483
2 pheochromocytoma 27.2 TMEM127 SYP SST SLC6A2 SDHD SDHC
3 plethora of newborn 10.4 SDHD SDHB
4 skin lipoma 10.3 RET NF1
5 solid adenocarcinoma with mucin production 10.3 RET CHGA
6 sporadic pheochromocytoma/secreting paraganglioma 10.3 SDHD SDHB RET
7 b-lymphoblastic leukemia/lymphoma with hypodiploidy 10.3 SDHA RET
8 nonsyndromic paraganglioma 10.3 SDHB RET CHGA
9 dermis tumor 10.3 SDHD SDHA
10 primary hepatic neuroendocrine carcinoma 10.3 SYP CHGA
11 esophageal neuroendocrine tumor 10.3 SYP CHGA
12 auditory system benign neoplasm 10.3 SYP CHGA
13 small cell carcinoma of the bladder 10.3 SYP CHGA
14 auditory system cancer 10.3 SYP CHGA
15 acinar cell cystadenocarcinoma 10.3 SYP CHGA
16 neuronal intestinal dysplasia, type b 10.3 SYP RET
17 vulvar eccrine porocarcinoma 10.3 SYP CHGA
18 pancreatic serous cystadenocarcinoma 10.3 SYP CHGA
19 cauda equina neoplasm 10.3 SYP CHGA
20 horner's syndrome 10.3 SDHD NF1
21 appendix carcinoid tumor 10.3 SYP CHGA
22 vaginal tubulovillous adenoma 10.2 SYP CHGA
23 mixed ductal-endocrine carcinoma 10.2 SYP CHGA
24 laryngeal small cell carcinoma 10.2 SYP CHGA
25 gallbladder small cell carcinoma 10.2 SYP CHGA
26 ureter small cell carcinoma 10.2 SYP CHGA
27 papillary thymic adenocarcinoma 10.2 SYP CHGA
28 middle ear adenoma 10.2 SYP CHGA
29 hypoganglionosis 10.2 SYP RET
30 urinary bladder small cell neuroendocrine carcinoma 10.2 SYP CHGA
31 gastric small cell carcinoma 10.2 SYP CHGA
32 breast papillary carcinoma 10.2 SYP CHGA
33 extracranial neuroblastoma 10.2 SYP CHGA
34 sensory organ benign neoplasm 10.2 SYP CHGA
35 cervical neuroblastoma 10.2 SYP CHGA
36 esophageal adenoid cystic carcinoma 10.2 SYP CHGA
37 epithelioid malignant peripheral nerve sheath tumor 10.2 NF1 CHGA
38 ovarian large-cell neuroendocrine carcinoma 10.2 SYP CHGA
39 appendix adenocarcinoma 10.2 SYP CHGA
40 neurofibromatosis, type ii 10.2 SDHD SDHB NF1
41 subependymoma 10.2 SYP CHGA
42 pineocytoma 10.2 SYP CHGA
43 cutaneous ganglioneuroma 10.2 SYP CHGA
44 optic nerve astrocytoma 10.2 SYP NF1
45 cervix small cell carcinoma 10.2 SYP CHGA
46 adrenal neuroblastoma 10.2 SYP CHGA
47 spastic paraplegia 38, autosomal dominant 10.2 SDHB SDHA
48 subglottis neoplasm 10.2 SDHC SDHB NF1
49 ovarian germ cell teratoma 10.2 SYP RET
50 endometrial small cell carcinoma 10.2 SYP CHGA

Graphical network of the top 20 diseases related to Adrenal Medulla Cancer:



Diseases related to Adrenal Medulla Cancer

Symptoms & Phenotypes for Adrenal Medulla Cancer

MGI Mouse Phenotypes related to Adrenal Medulla Cancer:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.4 CHGA NF1 PNMT RET SDHA SDHB

Drugs & Therapeutics for Adrenal Medulla Cancer

Search Clinical Trials , NIH Clinical Center for Adrenal Medulla Cancer

Genetic Tests for Adrenal Medulla Cancer

Anatomical Context for Adrenal Medulla Cancer

The Foundational Model of Anatomy Ontology organs/tissues related to Adrenal Medulla Cancer:

19
Adrenal Medulla

MalaCards organs/tissues related to Adrenal Medulla Cancer:

40
Adrenal Gland, Thyroid, Cerebellum

Publications for Adrenal Medulla Cancer

Articles related to Adrenal Medulla Cancer:

# Title Authors PMID Year
1
Lycium europaeum fruit extract: antiproliferative activity on A549 human lung carcinoma cells and PC12 rat adrenal medulla cancer cells and assessment of its cytotoxicity on cerebellum granule cells. 61
25825796 2015

Variations for Adrenal Medulla Cancer

Expression for Adrenal Medulla Cancer

Search GEO for disease gene expression data for Adrenal Medulla Cancer.

Pathways for Adrenal Medulla Cancer

GO Terms for Adrenal Medulla Cancer

Cellular components related to Adrenal Medulla Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 neuronal dense core vesicle GO:0098992 9.16 SCG2 CHGA
2 respiratory chain complex II GO:0045273 8.96 SDHC SDHB
3 mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone) GO:0005749 8.92 SDHD SDHC SDHB SDHA

Biological processes related to Adrenal Medulla Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 electron transport chain GO:0022900 9.43 SDHC SDHB SDHA
2 response to pain GO:0048265 9.37 SLC6A2 RET
3 tricarboxylic acid cycle GO:0006099 9.35 SDHD SDHC SDHB SDHAF2 SDHA
4 respiratory electron transport chain GO:0022904 9.32 SDHB SDHA
5 succinate metabolic process GO:0006105 9.16 SDHB SDHA
6 mitochondrial electron transport, succinate to ubiquinone GO:0006121 8.92 SDHD SDHC SDHAF2 SDHA

Molecular functions related to Adrenal Medulla Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 ubiquinone binding GO:0048039 9.26 SDHD SDHB
2 electron transfer activity GO:0009055 9.26 SDHD SDHC SDHB SDHA
3 succinate dehydrogenase (ubiquinone) activity GO:0008177 9.16 SDHB SDHA
4 succinate dehydrogenase activity GO:0000104 8.8 SDHD SDHC SDHA

Sources for Adrenal Medulla Cancer

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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