MCID: ADR014
MIFTS: 30

Adrenal Medulla Cancer

Categories: Cancer diseases, Endocrine diseases, Rare diseases

Aliases & Classifications for Adrenal Medulla Cancer

MalaCards integrated aliases for Adrenal Medulla Cancer:

Name: Adrenal Medulla Cancer 12 53 15
Malignant Tumor of the Adrenal Medulla 12
Malignant Neoplasm of Adrenal Medulla 12
Neoplasm of Adrenal Medulla 73
Adrenal Medulla Carcinoma 12
Adrenal Medulla Neoplasm 12
Adrenal Medulla Tumor 12

Classifications:



External Ids:

Disease Ontology 12 DOID:5719 DOID:7379
ICD10 33 C74.1
SNOMED-CT 68 93666006

Summaries for Adrenal Medulla Cancer

Disease Ontology : 12 An adrenal gland cancer that is located in the adrenal medulla.

MalaCards based summary : Adrenal Medulla Cancer, also known as malignant tumor of the adrenal medulla, is related to malignant pheochromocytoma and extra-adrenal pheochromocytoma. An important gene associated with Adrenal Medulla Cancer is SDHB (Succinate Dehydrogenase Complex Iron Sulfur Subunit B), and among its related pathways/superpathways are Carbon metabolism and Pyruvate metabolism and Citric Acid (TCA) cycle. Affiliated tissues include adrenal gland, lymph node and the adrenal medulla, and related phenotype is cardiovascular system.

Related Diseases for Adrenal Medulla Cancer

Diseases related to Adrenal Medulla Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 33)
# Related Disease Score Top Affiliating Genes
1 malignant pheochromocytoma 31.7 CHGA PNMT SDHB
2 extra-adrenal pheochromocytoma 31.4 PNMT SDHAF2 SDHB SDHC SDHD
3 pheochromocytoma 28.8 CHGA PNMT RET SCG2 SDHAF2 SDHB
4 adrenal gland pheochromocytoma 11.2
5 glomus tumor 10.1 SDHB SDHD
6 carcinoid tumors, intestinal 10.1 CHGA SDHD
7 chondroma 10.1 SDHB SDHC SDHD
8 paraganglioma and gastric stromal sarcoma 10.1 SDHB SDHC SDHD
9 carney triad 10.0 SDHB SDHC SDHD
10 intracranial primitive neuroectodermal tumor 10.0 CHGA SCG2
11 multiple endocrine neoplasia, type iia 10.0 RET SDHB SDHD
12 ganglioneuroma 10.0 CHGA RET
13 collagenous colitis 10.0 CHGA SCG2
14 sporadic pheochromocytoma 9.9 RET SDHB SDHC SDHD
15 neurofibromatosis, type iv, of riccardi 9.9 RET SDHB SDHC SDHD
16 neural crest tumor 9.9 SDHAF2 SDHB SDHC SDHD
17 multiple endocrine neoplasia, type i 9.9 CHGA RET SDHB SDHD
18 parathyroid adenoma 9.9 CHGA RET
19 persistent generalized lymphadenopathy 9.9 SDHAF2 SDHB SDHC SDHD
20 gastrointestinal stromal tumor 9.9 CHGA SDHB SDHC SDHD
21 cerebellopontine angle tumor 9.9 ENSG00000255292 SDHD
22 paragangliomas 1 9.8 CHGA RET SDHB SDHC SDHD
23 cowden disease 9.8 CHGA RET SDHB SDHC SDHD
24 hereditary paraganglioma-pheochromocytoma syndromes 9.8 RET SDHAF2 SDHB SDHC SDHD
25 plethora of newborn 9.8 ENSG00000255292 SDHB SDHC SDHD
26 lymphatic system disease 9.8 ENSG00000255292 SDHB SDHC SDHD
27 autosomal genetic disease 9.8 ENSG00000255292 RET SDHB SDHD
28 multiple endocrine neoplasia 9.7 CHGA PNMT RET SDHB SDHC
29 paraganglioma 9.7 CHGA RET SDHAF2 SDHB SDHC SDHD
30 lymph node disease 9.6 ENSG00000255292 SDHAF2 SDHB SDHC SDHD
31 mitochondrial complex ii deficiency 9.6 ENSG00000255292 SDHAF2 SDHB SDHC SDHD
32 von hippel-lindau syndrome 9.6 CHGA PNMT RET SDHB SDHC SDHD
33 endocrine organ benign neoplasm 9.4 CHGA ENSG00000255292 RET SDHAF2 SDHB SDHC

Graphical network of the top 20 diseases related to Adrenal Medulla Cancer:



Diseases related to Adrenal Medulla Cancer

Symptoms & Phenotypes for Adrenal Medulla Cancer

MGI Mouse Phenotypes related to Adrenal Medulla Cancer:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.1 CHGA PNMT RET SCG2 SDHB SDHD

Drugs & Therapeutics for Adrenal Medulla Cancer

Search Clinical Trials , NIH Clinical Center for Adrenal Medulla Cancer

Genetic Tests for Adrenal Medulla Cancer

Anatomical Context for Adrenal Medulla Cancer

MalaCards organs/tissues related to Adrenal Medulla Cancer:

41
Adrenal Gland, Lymph Node

The Foundational Model of Anatomy Ontology organs/tissues related to Adrenal Medulla Cancer:

19
The Adrenal Medulla

Publications for Adrenal Medulla Cancer

Articles related to Adrenal Medulla Cancer:

# Title Authors Year
1
Inhibition of Cdc42 and Rac1 activities in pheochromocytoma, the adrenal medulla tumor. ( 27355516 )
2017

Variations for Adrenal Medulla Cancer

Expression for Adrenal Medulla Cancer

Search GEO for disease gene expression data for Adrenal Medulla Cancer.

Pathways for Adrenal Medulla Cancer

GO Terms for Adrenal Medulla Cancer

Cellular components related to Adrenal Medulla Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 mitochondrial inner membrane GO:0005743 9.46 ENSG00000255292 SDHB SDHC SDHD
2 mitochondrial envelope GO:0005740 9.26 ENSG00000255292 SDHD
3 respiratory chain complex II GO:0045273 8.96 SDHB SDHC
4 mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone) GO:0005749 8.92 ENSG00000255292 SDHB SDHC SDHD

Biological processes related to Adrenal Medulla Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 oxidation-reduction process GO:0055114 9.56 ENSG00000255292 SDHB SDHC SDHD
2 tricarboxylic acid cycle GO:0006099 9.35 ENSG00000255292 SDHAF2 SDHB SDHC SDHD
3 aerobic respiration GO:0009060 9.16 SDHB SDHC
4 mitochondrial electron transport, succinate to ubiquinone GO:0006121 8.92 ENSG00000255292 SDHAF2 SDHC SDHD

Molecular functions related to Adrenal Medulla Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 heme binding GO:0020037 9.43 ENSG00000255292 SDHC SDHD
2 electron transfer activity GO:0009055 9.33 SDHB SDHC SDHD
3 succinate dehydrogenase (ubiquinone) activity GO:0008177 9.13 SDHB SDHC SDHD
4 ubiquinone binding GO:0048039 8.92 ENSG00000255292 SDHB SDHC SDHD

Sources for Adrenal Medulla Cancer

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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