Adrenal Medulla Cancer disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Adrenal Medulla Cancer

MalaCards integrated aliases for Adrenal Medulla Cancer:

Name: Adrenal Medulla Cancer ¹² ⁵³ ¹⁵

Malignant Tumor of the Adrenal Medulla ¹²

Malignant Neoplasm of Adrenal Medulla ¹²

Neoplasm of Adrenal Medulla ⁷²

Adrenal Medulla Carcinoma ¹²

Adrenal Medulla Neoplasm ¹²

Adrenal Medulla Tumor ¹²

Classifications:

MalaCards categories:
Global: Rare diseases Cancer diseases
Anatomical: Endocrine diseases

See all MalaCards categories (disease lists)

ICD10: ³³

Neoplasms

Malignant neoplasms of thyroid and other endocrine glands

Malignant neoplasm of adrenal gland

Malignant neoplasm: Medulla of adrenal gland

External Ids:

Disease Ontology ¹² DOID:5719 DOID:7379

NCIt ⁵⁰ C4396 C4856 C9276

SNOMED-CT ⁶⁸ 93666006

ICD10 ³³ C74.1

UMLS ⁷² C0344456 C0596046 C1334717

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Summaries for Adrenal Medulla Cancer

Disease Ontology : ¹² An adrenal gland cancer that is located in the adrenal medulla.

MalaCards based summary : Adrenal Medulla Cancer, also known as malignant tumor of the adrenal medulla, is related to malignant pheochromocytoma and pheochromocytoma. An important gene associated with Adrenal Medulla Cancer is SDHB (Succinate Dehydrogenase Complex Iron Sulfur Subunit B), and among its related pathways/superpathways are Carbon metabolism and Pyruvate metabolism and Citric Acid (TCA) cycle. Affiliated tissues include adrenal gland, thyroid and lung, and related phenotypes are cardiovascular system and homeostasis/metabolism

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Related Diseases for Adrenal Medulla Cancer

Diseases related to Adrenal Medulla Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 41)

#	Related Disease	Score	Top Affiliating Genes
1	malignant pheochromocytoma	31.7	SDHB PNMT CHGA
2	pheochromocytoma	25.5	TMEM127 SDHD SDHC SDHB SDHAF2 SDHA
3	glomus tumor	10.4	SDHD SDHB
4	intracranial primitive neuroectodermal tumor	10.4	SCG2 CHGA
5	carcinoid tumors, intestinal	10.4	SDHD CHGA
6	epithelioid malignant peripheral nerve sheath tumor	10.3	NF1 CHGA
7	autonomic nervous system benign neoplasm	10.3	NF1 CHGA
8	chondroma	10.3	SDHD SDHC SDHB
9	paraganglioma and gastric stromal sarcoma	10.3	SDHD SDHC SDHB
10	plethora of newborn	10.3	SDHD SDHC SDHB
11	collagenous colitis	10.2	SCG2 CHGA
12	spinal canal and spinal cord meningioma	10.2	NF1 CHGA
13	endodermal sinus tumor	10.2	CHGA CGB3
14	seminal vesicle tumor	10.2	SDHB SDHA
15	spinal meningioma	10.2	NF1 CHGA
16	adrenal gland pheochromocytoma	10.1
17	spastic quadriplegia	10.1	SDHD SDHA
18	quadriplegia	10.1	SDHD SDHA
19	ganglioneuroma	10.0	RET CHGA
20	multiple endocrine neoplasia, type i	10.0	SDHD SDHB RET CHGA
21	lymphatic system disease	10.0	TMEM127 SDHD SDHC SDHB
22	mixed ductal-endocrine carcinoma	9.9	CHGA CGB3
23	generalized epilepsy with febrile seizures plus	9.9
24	multiple endocrine neoplasia, type iia	9.9	SDHD SDHB RET NF1
25	autosomal genetic disease	9.9	SDHD SDHB RET NF1
26	carney triad	9.7	SDHD SDHC SDHB SDHA
27	paragangliomas 1	9.7	SDHD SDHC SDHB RET CHGA
28	serotonin syndrome	9.7	CHGA CGB3
29	sporadic pheochromocytoma	9.6	SDHD SDHC SDHB RET NF1
30	neurofibromatosis, type iv, of riccardi	9.6	SDHD SDHC SDHB RET NF1
31	neural crest tumor	9.3	SDHD SDHC SDHB SDHAF2 SDHA
32	mitochondrial complex ii deficiency	9.3	SDHD SDHC SDHB SDHAF2 SDHA
33	extra-adrenal pheochromocytoma	9.1	SDHD SDHC SDHB SDHAF2 PNMT
34	gastrointestinal stromal tumor	9.1	SDHD SDHC SDHB SDHA NF1 CHGA
35	persistent generalized lymphadenopathy	8.9	TMEM127 SDHD SDHC SDHB SDHAF2 SDHA
36	lymph node disease	8.9	TMEM127 SDHD SDHC SDHB SDHAF2 SDHA
37	multiple endocrine neoplasia	8.8	SDHC SDHB RET PNMT NF1 CHGA
38	hereditary paraganglioma-pheochromocytoma syndromes	8.6	TMEM127 SDHD SDHC SDHB SDHAF2 SDHA
39	von hippel-lindau syndrome	8.6	SDHD SDHC SDHB RET PNMT NF1
40	endocrine organ benign neoplasm	8.3	TMEM127 SDHD SDHC SDHB SDHAF2 SDHA
41	paraganglioma	7.9	TMEM127 SDHD SDHC SDHB SDHAF2 SDHA

Graphical network of the top 20 diseases related to Adrenal Medulla Cancer:

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Symptoms & Phenotypes for Adrenal Medulla Cancer

MGI Mouse Phenotypes related to Adrenal Medulla Cancer:

⁴⁶

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	cardiovascular system	MP:0005385	9.43	CHGA NF1 PNMT RET SCG2 SDHD
2	homeostasis/metabolism	MP:0005376	9.28	CHGA NF1 PNMT RET SDHA SDHB

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Drugs & Therapeutics for Adrenal Medulla Cancer

Search Clinical Trials , NIH Clinical Center for Adrenal Medulla Cancer

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Genetic Tests for Adrenal Medulla Cancer

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Anatomical Context for Adrenal Medulla Cancer

MalaCards organs/tissues related to Adrenal Medulla Cancer:

⁴¹

Adrenal Gland, Thyroid, Lung, Cerebellum

The Foundational Model of Anatomy Ontology organs/tissues related to Adrenal Medulla Cancer:

¹⁹

Adrenal Medulla

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Publications for Adrenal Medulla Cancer

Articles related to Adrenal Medulla Cancer:

#	Title	Authors	PMID	Year
1	Lycium europaeum fruit extract: antiproliferative activity on A549 human lung carcinoma cells and PC12 rat adrenal medulla cancer cells and assessment of its cytotoxicity on cerebellum granule cells. ³⁸	Ghali W...Marzouki MN	25825796	2015

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Genes for Adrenal Medulla Cancer

Genes related to Adrenal Medulla Cancer (0 elite genes):

(show all 13)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	SDHB	Succinate Dehydrogenase Complex Iron Sulfur Subunit B	Protein Coding	17.51	DISEASES inferred ¹⁵
2	SDHD	Succinate Dehydrogenase Complex Subunit D	Protein Coding	16.95	DISEASES inferred ¹⁵
3	SDHC	Succinate Dehydrogenase Complex Subunit C	Protein Coding	16.3	DISEASES inferred ¹⁵
4	SCG2	Secretogranin II	Protein Coding	16.27	DISEASES inferred ¹⁵
5	CHGA	Chromogranin A	Protein Coding	15.9	DISEASES inferred ¹⁵
6	RET	Ret Proto-Oncogene	Protein Coding	15.81	DISEASES inferred ¹⁵
7	TMEM127	Transmembrane Protein 127	Protein Coding	15.36	DISEASES inferred ¹⁵
8	NF1	Neurofibromin 1	Protein Coding	15.14	DISEASES inferred ¹⁵
9	BMS1	BMS1 Ribosome Biogenesis Factor	Protein Coding	15.13	DISEASES inferred ¹⁵
10	SDHAF2	Succinate Dehydrogenase Complex Assembly Factor 2	Protein Coding	15.09	DISEASES inferred ¹⁵
11	SDHA	Succinate Dehydrogenase Complex Flavoprotein Subunit A	Protein Coding	15.08	DISEASES inferred ¹⁵
12	PNMT	Phenylethanolamine N-Methyltransferase	Protein Coding	14.99	DISEASES inferred ¹⁵
13	CGB3	Chorionic Gonadotropin Subunit Beta 3	Protein Coding	14.98	DISEASES inferred ¹⁵

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Variations for Adrenal Medulla Cancer

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Expression for Adrenal Medulla Cancer

Search GEO for disease gene expression data for Adrenal Medulla Cancer.

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Pathways for Adrenal Medulla Cancer

Pathways related to Adrenal Medulla Cancer according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Carbon metabolism ³⁷ Show member pathways 2-Oxocarboxylic acid metabolism ³⁷ Biosynthesis of amino acids ³⁷ formaldehyde oxidation ¹	11.78	SDHD SDHC SDHB SDHA
2	Pyruvate metabolism and Citric Acid (TCA) cycle ⁶⁶ Show member pathways Citric acid cycle (TCA cycle) ⁶⁶ Interconversion of 2-oxoglutarate and 2-hydroxyglutarate ⁶⁶ NAD phosphorylation and dephosphorylation ¹ Pyruvate metabolism ⁶⁶ Regulation of pyruvate dehydrogenase (PDH) complex ⁶⁶ TCA Cycle ¹	11.37	SDHD SDHC SDHB SDHA
3	Aryl Hydrocarbon Receptor ¹	10.94	RET NF1
4	Citrate cycle (TCA cycle) ³⁷ Show member pathways pyruvate decarboxylation to acetyl CoA ¹ superpathway of conversion of glucose to acetyl CoA and entry into the TCA cycle ¹ TCA cycle ¹ TCA Cycle and Deficiency of Pyruvate Dehydrogenase complex (PDHc) ¹	10.94	SDHD SDHC SDHB SDHA

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GO Terms for Adrenal Medulla Cancer

Cellular components related to Adrenal Medulla Cancer according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	mitochondrial inner membrane	GO:0005743	9.46	SDHD SDHC SDHB SDHA
2	respiratory chain complex II	GO:0045273	8.96	SDHC SDHB
3	mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)	GO:0005749	8.92	SDHD SDHC SDHB SDHA

Biological processes related to Adrenal Medulla Cancer according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	MAPK cascade	GO:0000165	9.63	SCG2 RET NF1
2	electron transport chain	GO:0022900	9.5	SDHC SDHB SDHA
3	negative regulation of endothelial cell proliferation	GO:0001937	9.43	SCG2 NF1
4	aerobic respiration	GO:0009060	9.4	SDHC SDHB
5	respiratory electron transport chain	GO:0022904	9.37	SDHB SDHA
6	tricarboxylic acid cycle	GO:0006099	9.35	SDHD SDHC SDHB SDHAF2 SDHA
7	positive regulation of extrinsic apoptotic signaling pathway in absence of ligand	GO:2001241	9.26	RET NF1
8	succinate metabolic process	GO:0006105	9.16	SDHB SDHA
9	mitochondrial electron transport, succinate to ubiquinone	GO:0006121	8.92	SDHD SDHC SDHAF2 SDHA

Molecular functions related to Adrenal Medulla Cancer according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	electron transfer activity	GO:0009055	9.46	SDHD SDHC SDHB SDHA
2	oxidoreductase activity, acting on the CH-CH group of donors	GO:0016627	9.32	SDHC SDHA
3	succinate dehydrogenase activity	GO:0000104	9.26	SDHD SDHA
4	ubiquinone binding	GO:0048039	8.96	SDHD SDHB
5	succinate dehydrogenase (ubiquinone) activity	GO:0008177	8.92	SDHD SDHC SDHB SDHA

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