Adrenal Medulla Cancer disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Adrenal Medulla Cancer

MalaCards integrated aliases for Adrenal Medulla Cancer:

Name: Adrenal Medulla Cancer ¹² ⁵³ ¹⁵

Malignant Tumor of the Adrenal Medulla ¹²

Malignant Neoplasm of Adrenal Medulla ¹²

Neoplasm of Adrenal Medulla ⁷³

Adrenal Medulla Carcinoma ¹²

Adrenal Medulla Neoplasm ¹²

Adrenal Medulla Tumor ¹²

Classifications:

MalaCards categories:
Global: Rare diseases Cancer diseases
Anatomical: Endocrine diseases

See all MalaCards categories (disease lists)

ICD10: ³³

Neoplasms

Malignant neoplasms of thyroid and other endocrine glands

Malignant neoplasm of adrenal gland

Malignant neoplasm: Medulla of adrenal gland

External Ids:

Disease Ontology ¹² DOID:5719 DOID:7379

ICD10 ³³ C74.1

NCIt ⁵⁰ C4396 C4856 C9276

SNOMED-CT ⁶⁸ 93666006

UMLS ⁷³ C0344456 C0596046 C1334717

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Summaries for Adrenal Medulla Cancer

Disease Ontology : ¹² An adrenal gland cancer that is located in the adrenal medulla.

MalaCards based summary : Adrenal Medulla Cancer, also known as malignant tumor of the adrenal medulla, is related to malignant pheochromocytoma and extra-adrenal pheochromocytoma. An important gene associated with Adrenal Medulla Cancer is SDHB (Succinate Dehydrogenase Complex Iron Sulfur Subunit B), and among its related pathways/superpathways are Carbon metabolism and Pyruvate metabolism and Citric Acid (TCA) cycle. Affiliated tissues include adrenal gland, lymph node and the adrenal medulla, and related phenotype is cardiovascular system.

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Related Diseases for Adrenal Medulla Cancer

Diseases related to Adrenal Medulla Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 33)

#	Related Disease	Score	Top Affiliating Genes
1	malignant pheochromocytoma	31.7	CHGA PNMT SDHB
2	extra-adrenal pheochromocytoma	31.4	PNMT SDHAF2 SDHB SDHC SDHD
3	pheochromocytoma	28.8	CHGA PNMT RET SCG2 SDHAF2 SDHB
4	adrenal gland pheochromocytoma	11.2
5	glomus tumor	10.1	SDHB SDHD
6	carcinoid tumors, intestinal	10.1	CHGA SDHD
7	chondroma	10.1	SDHB SDHC SDHD
8	paraganglioma and gastric stromal sarcoma	10.1	SDHB SDHC SDHD
9	carney triad	10.0	SDHB SDHC SDHD
10	intracranial primitive neuroectodermal tumor	10.0	CHGA SCG2
11	multiple endocrine neoplasia, type iia	10.0	RET SDHB SDHD
12	ganglioneuroma	10.0	CHGA RET
13	collagenous colitis	10.0	CHGA SCG2
14	sporadic pheochromocytoma	9.9	RET SDHB SDHC SDHD
15	neurofibromatosis, type iv, of riccardi	9.9	RET SDHB SDHC SDHD
16	neural crest tumor	9.9	SDHAF2 SDHB SDHC SDHD
17	multiple endocrine neoplasia, type i	9.9	CHGA RET SDHB SDHD
18	parathyroid adenoma	9.9	CHGA RET
19	persistent generalized lymphadenopathy	9.9	SDHAF2 SDHB SDHC SDHD
20	gastrointestinal stromal tumor	9.9	CHGA SDHB SDHC SDHD
21	cerebellopontine angle tumor	9.9	ENSG00000255292 SDHD
22	paragangliomas 1	9.8	CHGA RET SDHB SDHC SDHD
23	cowden disease	9.8	CHGA RET SDHB SDHC SDHD
24	hereditary paraganglioma-pheochromocytoma syndromes	9.8	RET SDHAF2 SDHB SDHC SDHD
25	plethora of newborn	9.8	ENSG00000255292 SDHB SDHC SDHD
26	lymphatic system disease	9.8	ENSG00000255292 SDHB SDHC SDHD
27	autosomal genetic disease	9.8	ENSG00000255292 RET SDHB SDHD
28	multiple endocrine neoplasia	9.7	CHGA PNMT RET SDHB SDHC
29	paraganglioma	9.7	CHGA RET SDHAF2 SDHB SDHC SDHD
30	lymph node disease	9.6	ENSG00000255292 SDHAF2 SDHB SDHC SDHD
31	mitochondrial complex ii deficiency	9.6	ENSG00000255292 SDHAF2 SDHB SDHC SDHD
32	von hippel-lindau syndrome	9.6	CHGA PNMT RET SDHB SDHC SDHD
33	endocrine organ benign neoplasm	9.4	CHGA ENSG00000255292 RET SDHAF2 SDHB SDHC

Graphical network of the top 20 diseases related to Adrenal Medulla Cancer:

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Symptoms & Phenotypes for Adrenal Medulla Cancer

MGI Mouse Phenotypes related to Adrenal Medulla Cancer:

⁴⁶

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	cardiovascular system	MP:0005385	9.1	CHGA PNMT RET SCG2 SDHB SDHD

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Drugs & Therapeutics for Adrenal Medulla Cancer

Search Clinical Trials , NIH Clinical Center for Adrenal Medulla Cancer

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Genetic Tests for Adrenal Medulla Cancer

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Anatomical Context for Adrenal Medulla Cancer

MalaCards organs/tissues related to Adrenal Medulla Cancer:

⁴¹

Adrenal Gland, Lymph Node

The Foundational Model of Anatomy Ontology organs/tissues related to Adrenal Medulla Cancer:

¹⁹

The Adrenal Medulla

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Publications for Adrenal Medulla Cancer

Articles related to Adrenal Medulla Cancer:

#	Title	Authors	Year
1	Inhibition of Cdc42 and Rac1 activities in pheochromocytoma, the adrenal medulla tumor. ( 27355516 )	CroisAc P....Ory S.	2017

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Genes for Adrenal Medulla Cancer

Genes related to Adrenal Medulla Cancer (0 elite genes):

(show all 11)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	SDHB	Succinate Dehydrogenase Complex Iron Sulfur Subunit B	Protein Coding	17.16	DISEASES inferred ¹⁵
2	SDHD	Succinate Dehydrogenase Complex Subunit D	Protein Coding	16.72	DISEASES inferred ¹⁵
3	SDHC	Succinate Dehydrogenase Complex Subunit C	Protein Coding	16.07	DISEASES inferred ¹⁵
4	RET	Ret Proto-Oncogene	Protein Coding	15.68	DISEASES inferred ¹⁵
5	CHGA	Chromogranin A	Protein Coding	15.66	DISEASES inferred ¹⁵
6	BMS1	BMS1, Ribosome Biogenesis Factor	Protein Coding	15.4	DISEASES inferred ¹⁵
7	SDHAF2	Succinate Dehydrogenase Complex Assembly Factor 2	Protein Coding	15.13	DISEASES inferred ¹⁵
8	SCG2	Secretogranin II	Protein Coding	14.92	DISEASES inferred ¹⁵
9	PNMT	Phenylethanolamine N-Methyltransferase	Protein Coding	14.87	DISEASES inferred ¹⁵
10	ENSG00000255292		Protein Coding	6.74	DISEASES inferred ¹⁵
11	ZNF367	Zinc Finger Protein 367	Protein Coding	5.76	DISEASES inferred ¹⁵

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Variations for Adrenal Medulla Cancer

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Expression for Adrenal Medulla Cancer

Search GEO for disease gene expression data for Adrenal Medulla Cancer.

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Pathways for Adrenal Medulla Cancer

Pathways related to Adrenal Medulla Cancer according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Carbon metabolism ³⁷ Show member pathways 2-Oxocarboxylic acid metabolism ³⁷ Biosynthesis of amino acids ³⁷ formaldehyde oxidation ¹	11.66	SDHB SDHC SDHD
2	Pyruvate metabolism and Citric Acid (TCA) cycle ⁶⁶ Show member pathways Citric acid cycle (TCA cycle) ⁶⁶ Interconversion of 2-oxoglutarate and 2-hydroxyglutarate ⁶⁶ NAD phosphorylation and dephosphorylation ¹ Pyruvate metabolism ⁶⁶ Regulation of pyruvate dehydrogenase (PDH) complex ⁶⁶ TCA Cycle ¹	11.25	SDHB SDHC SDHD
3	Citrate cycle (TCA cycle) ³⁷ Show member pathways pyruvate decarboxylation to acetyl CoA ¹ superpathway of conversion of glucose to acetyl CoA and entry into the TCA cycle ¹ TCA cycle ¹ TCA Cycle and Deficiency of Pyruvate Dehydrogenase complex (PDHc) ¹	10.81	SDHB SDHC SDHD

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GO Terms for Adrenal Medulla Cancer

Cellular components related to Adrenal Medulla Cancer according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	mitochondrial inner membrane	GO:0005743	9.46	ENSG00000255292 SDHB SDHC SDHD
2	mitochondrial envelope	GO:0005740	9.26	ENSG00000255292 SDHD
3	respiratory chain complex II	GO:0045273	8.96	SDHB SDHC
4	mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)	GO:0005749	8.92	ENSG00000255292 SDHB SDHC SDHD

Biological processes related to Adrenal Medulla Cancer according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	oxidation-reduction process	GO:0055114	9.56	ENSG00000255292 SDHB SDHC SDHD
2	tricarboxylic acid cycle	GO:0006099	9.35	ENSG00000255292 SDHAF2 SDHB SDHC SDHD
3	aerobic respiration	GO:0009060	9.16	SDHB SDHC
4	mitochondrial electron transport, succinate to ubiquinone	GO:0006121	8.92	ENSG00000255292 SDHAF2 SDHC SDHD

Molecular functions related to Adrenal Medulla Cancer according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	heme binding	GO:0020037	9.43	ENSG00000255292 SDHC SDHD
2	electron transfer activity	GO:0009055	9.33	SDHB SDHC SDHD
3	succinate dehydrogenase (ubiquinone) activity	GO:0008177	9.13	SDHB SDHC SDHD
4	ubiquinone binding	GO:0048039	8.92	ENSG00000255292 SDHB SDHC SDHD

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Sources for Adrenal Medulla Cancer

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