Adrenal Medulla Cancer disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Adrenal Medulla Cancer

MalaCards integrated aliases for Adrenal Medulla Cancer:

Name: Adrenal Medulla Cancer ¹² ⁵² ¹⁵

Malignant Tumor of the Adrenal Medulla ¹²

Malignant Neoplasm of Adrenal Medulla ¹²

Neoplasm of Adrenal Medulla ⁷¹

Adrenal Medulla Carcinoma ¹²

Adrenal Medulla Neoplasm ¹²

Adrenal Medulla Tumor ¹²

Classifications:

MalaCards categories:
Global: Rare diseases Cancer diseases
Anatomical: Endocrine diseases

See all MalaCards categories (disease lists)

ICD10: ³²

Neoplasms

Malignant neoplasms of thyroid and other endocrine glands

Malignant neoplasm of adrenal gland

Malignant neoplasm: Medulla of adrenal gland

External Ids:

Disease Ontology ¹² DOID:5719 DOID:7379

NCIt ⁴⁹ C4396 C4856 C9276

SNOMED-CT ⁶⁷ 127023007 371965009

ICD10 ³² C74.1

UMLS ⁷¹ C0344456 C0596046 C1334717

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Summaries for Adrenal Medulla Cancer

Disease Ontology : ¹² An adrenal gland cancer that is located in the adrenal medulla.

MalaCards based summary : Adrenal Medulla Cancer, also known as malignant tumor of the adrenal medulla, is related to malignant pheochromocytoma and pheochromocytoma. An important gene associated with Adrenal Medulla Cancer is MIR483 (MicroRNA 483), and among its related pathways/superpathways are Pyruvate metabolism and Citric Acid (TCA) cycle and Carbon metabolism. Affiliated tissues include adrenal medulla, adrenal gland and thyroid, and related phenotype is homeostasis/metabolism.

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Related Diseases for Adrenal Medulla Cancer

Diseases related to Adrenal Medulla Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 173)

#	Related Disease	Score	Top Affiliating Genes
1	malignant pheochromocytoma	30.2	SYP SST SLC6A2 SDHB PNMT MIR483
2	pheochromocytoma	25.9	TMEM127 SYP SST SLC6A2 SDHD SDHC
3	multiple mucosal neuroma	10.4	SDHAF2 RET
4	sporadic pheochromocytoma/secreting paraganglioma	10.4	SDHD SDHB RET
5	solid adenocarcinoma with mucin production	10.4	RET CHGA
6	breast neuroendocrine neoplasm	10.4	SYP CHGA
7	primary hepatic neuroendocrine carcinoma	10.4	SYP CHGA
8	small cell carcinoma of the bladder	10.4	SYP CHGA
9	acinar cell cystadenocarcinoma	10.4	SYP CHGA
10	vulvar eccrine porocarcinoma	10.4	SYP CHGA
11	cervical large cell neuroendocrine carcinoma	10.4	SYP CHGA
12	auditory system benign neoplasm	10.4	SYP CHGA
13	appendix carcinoid tumor	10.4	SYP CHGA
14	auditory system cancer	10.4	SYP CHGA
15	mixed ductal-endocrine carcinoma	10.4	SYP CHGA
16	esophageal neuroendocrine tumor	10.3	SYP CHGA
17	pancreatic serous cystadenocarcinoma	10.3	SYP CHGA
18	cauda equina neoplasm	10.3	SYP CHGA
19	vaginal tubulovillous adenoma	10.3	SYP CHGA
20	hypoganglionosis	10.3	SYP RET
21	urinary bladder small cell neuroendocrine carcinoma	10.3	SYP CHGA
22	ureter small cell carcinoma	10.3	SYP CHGA
23	papillary thymic adenocarcinoma	10.3	SYP CHGA
24	breast papillary carcinoma	10.3	SYP CHGA
25	laryngeal neuroendocrine tumor	10.3	SYP CHGA
26	multiple endocrine neoplasia	10.3	SDHC SDHB RET
27	middle ear adenoma	10.3	SYP CHGA
28	laryngeal small cell carcinoma	10.3	SYP CHGA
29	gallbladder small cell carcinoma	10.3	SYP CHGA
30	b-lymphoblastic leukemia/lymphoma with hypodiploidy	10.3	SDHA RET
31	gastric small cell carcinoma	10.3	SYP CHGA
32	esophageal adenoid cystic carcinoma	10.3	SYP CHGA
33	sensory organ benign neoplasm	10.3	SYP CHGA
34	subependymoma	10.3	SYP CHGA
35	pineocytoma	10.3	SYP CHGA
36	ovarian large-cell neuroendocrine carcinoma	10.3	SYP CHGA
37	appendix adenocarcinoma	10.3	SYP CHGA
38	lung oat cell carcinoma	10.3	SYP CHGA
39	epithelioid malignant peripheral nerve sheath tumor	10.3	NF1 CHGA
40	cutaneous ganglioneuroma	10.3	SYP CHGA
41	cervical neuroblastoma	10.3	SYP CHGA
42	cervix small cell carcinoma	10.3	SYP CHGA
43	pulmonary large cell neuroendocrine carcinoma	10.3	SYP CHGA
44	vaginal adenoma	10.3	SYP CHGA
45	ovarian germ cell teratoma	10.3	SYP RET
46	intracranial primitive neuroectodermal tumor	10.3	SYP SCG2
47	optic nerve astrocytoma	10.3	SYP NF1
48	endometrial small cell carcinoma	10.3	SYP CHGA
49	pancreatic acinar cell adenocarcinoma	10.3	SYP CHGA
50	colon neuroendocrine neoplasm	10.3	SYP CHGA

Graphical network of the top 20 diseases related to Adrenal Medulla Cancer:

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Symptoms & Phenotypes for Adrenal Medulla Cancer

MGI Mouse Phenotypes related to Adrenal Medulla Cancer:

⁴⁵

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	homeostasis/metabolism	MP:0005376	9.4	CHGA NF1 PNMT RET SDHA SDHB

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Drugs & Therapeutics for Adrenal Medulla Cancer

Search Clinical Trials , NIH Clinical Center for Adrenal Medulla Cancer

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Genetic Tests for Adrenal Medulla Cancer

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Anatomical Context for Adrenal Medulla Cancer

The Foundational Model of Anatomy Ontology organs/tissues related to Adrenal Medulla Cancer:

¹⁹

Adrenal Medulla

MalaCards organs/tissues related to Adrenal Medulla Cancer:

⁴⁰

Adrenal Gland, Thyroid, Cerebellum, Lung

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Publications for Adrenal Medulla Cancer

Articles related to Adrenal Medulla Cancer:

#	Title	Authors	PMID	Year
1	Lycium europaeum fruit extract: antiproliferative activity on A549 human lung carcinoma cells and PC12 rat adrenal medulla cancer cells and assessment of its cytotoxicity on cerebellum granule cells. ⁶¹	Ghali W...Marzouki MN	25825796	2015

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Genes for Adrenal Medulla Cancer

Genes related to Adrenal Medulla Cancer (0 elite genes):

(show all 19)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	MIR483	MicroRNA 483	RNA Gene	10.8	DISEASES inferred ¹⁵ ¹⁵
2	SDHB	Succinate Dehydrogenase Complex Iron Sulfur Subunit B	Protein Coding	8.1	DISEASES inferred ¹⁵
3	SDHD	Succinate Dehydrogenase Complex Subunit D	Protein Coding	8.04	DISEASES inferred ¹⁵
4	MIR513A1	MicroRNA 513a-1	RNA Gene	7.84	DISEASES inferred ¹⁵ ¹⁵
5	TMEM127	Transmembrane Protein 127	Protein Coding	7.31	DISEASES inferred ¹⁵
6	PGLS	6-Phosphogluconolactonase	Protein Coding	7.28	DISEASES inferred ¹⁵
7	CHGA	Chromogranin A	Protein Coding	7.09	DISEASES inferred ¹⁵
8	RET	Ret Proto-Oncogene	Protein Coding	7.07	DISEASES inferred ¹⁵
9	SDHC	Succinate Dehydrogenase Complex Subunit C	Protein Coding	6.98	DISEASES inferred ¹⁵
10	SDHAF2	Succinate Dehydrogenase Complex Assembly Factor 2	Protein Coding	6.78	DISEASES inferred ¹⁵
11	NF1	Neurofibromin 1	Protein Coding	6.76	DISEASES inferred ¹⁵
12	SDHA	Succinate Dehydrogenase Complex Flavoprotein Subunit A	Protein Coding	6.71	DISEASES inferred ¹⁵
13	SCG2	Secretogranin II	Protein Coding	6.6	DISEASES inferred ¹⁵
14	SYP	Synaptophysin	Protein Coding	6.59	DISEASES inferred ¹⁵
15	PNMT	Phenylethanolamine N-Methyltransferase	Protein Coding	6.48	DISEASES inferred ¹⁵
16	C9orf147	Chromosome 9 Open Reading Frame 147	Protein Coding	6.43	DISEASES inferred ¹⁵
17	ZNF367	Zinc Finger Protein 367	Protein Coding	6.29	DISEASES inferred ¹⁵
18	SST	Somatostatin	Protein Coding	6.23	DISEASES inferred ¹⁵
19	SLC6A2	Solute Carrier Family 6 Member 2	Protein Coding	5.99	DISEASES inferred ¹⁵

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Variations for Adrenal Medulla Cancer

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Expression for Adrenal Medulla Cancer

Search GEO for disease gene expression data for Adrenal Medulla Cancer.

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Pathways for Adrenal Medulla Cancer

Pathways related to Adrenal Medulla Cancer according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Pyruvate metabolism and Citric Acid (TCA) cycle ⁶⁵ Show member pathways Citric acid cycle (TCA cycle) ⁶⁵ Interconversion of 2-oxoglutarate and 2-hydroxyglutarate ⁶⁵ NAD phosphorylation and dephosphorylation ¹ Pyruvate metabolism ⁶⁵ Regulation of pyruvate dehydrogenase (PDH) complex ⁶⁵ TCA Cycle ¹	11.57	SDHD SDHC SDHB SDHA
2	Carbon metabolism ³⁶ Show member pathways 2-Oxocarboxylic acid metabolism ³⁶ Biosynthesis of amino acids ³⁶ formaldehyde oxidation ¹	11.35	SDHD SDHC SDHB SDHA PGLS
3	Citrate cycle (TCA cycle) ³⁶ Show member pathways pyruvate decarboxylation to acetyl CoA ¹ superpathway of conversion of glucose to acetyl CoA and entry into the TCA cycle ¹ TCA cycle ¹ TCA Cycle and Deficiency of Pyruvate Dehydrogenase complex (PDHc) ¹	11.27	SDHD SDHC SDHB SDHA

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GO Terms for Adrenal Medulla Cancer

Cellular components related to Adrenal Medulla Cancer according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	neuronal dense core vesicle	GO:0098992	9.16	SCG2 CHGA
2	respiratory chain complex II	GO:0045273	8.96	SDHC SDHB
3	mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)	GO:0005749	8.92	SDHD SDHC SDHB SDHA

Biological processes related to Adrenal Medulla Cancer according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	electron transport chain	GO:0022900	9.5	SDHC SDHB SDHA
2	regulation of long-term neuronal synaptic plasticity	GO:0048169	9.43	SYP NF1
3	response to pain	GO:0048265	9.4	SLC6A2 RET
4	respiratory electron transport chain	GO:0022904	9.37	SDHB SDHA
5	tricarboxylic acid cycle	GO:0006099	9.35	SDHD SDHC SDHB SDHAF2 SDHA
6	positive regulation of extrinsic apoptotic signaling pathway in absence of ligand	GO:2001241	9.26	RET NF1
7	succinate metabolic process	GO:0006105	9.16	SDHB SDHA
8	mitochondrial electron transport, succinate to ubiquinone	GO:0006121	8.92	SDHD SDHC SDHAF2 SDHA

Molecular functions related to Adrenal Medulla Cancer according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	ubiquinone binding	GO:0048039	9.26	SDHD SDHB
2	electron transfer activity	GO:0009055	9.26	SDHD SDHC SDHB SDHA
3	succinate dehydrogenase (ubiquinone) activity	GO:0008177	9.16	SDHB SDHA
4	succinate dehydrogenase activity	GO:0000104	8.8	SDHD SDHC SDHA

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Sources for Adrenal Medulla Cancer

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