MCID: ADR001
MIFTS: 33

Adrenal Rest Tumor

Categories: Cancer diseases, Endocrine diseases
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Aliases & Classifications for Adrenal Rest Tumor

MalaCards integrated aliases for Adrenal Rest Tumor:

Name: Adrenal Rest Tumor 11 53 43 14 16 71
Adrenal Rest Neoplasm 11

Classifications:



External Ids:

Disease Ontology 11 DOID:1786
MeSH 43 D000314
NCIt 49 C2860
SNOMED-CT 68 54292009
UMLS 71 C0001630

Summaries for Adrenal Rest Tumor

MalaCards based summary: Adrenal Rest Tumor, also known as adrenal rest neoplasm, is related to luteoma and leydig cell tumor. An important gene associated with Adrenal Rest Tumor is CYP21A2 (Cytochrome P450 Family 21 Subfamily A Member 2), and among its related pathways/superpathways are Metabolism and Disease. Affiliated tissues include liver, ovary and hypothalamus, and related phenotypes are Reduced mammosphere formation and growth/size/body region

Related Diseases for Adrenal Rest Tumor

Diseases related to Adrenal Rest Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 88)
# Related Disease Score Top Affiliating Genes
1 luteoma 30.1 EPPIN CYP21A2
2 leydig cell tumor 30.1 INSL3 CYP21A2 CYP11A1
3 acute adrenal insufficiency 29.9 POMC CYP21A2 CYP11A1
4 infertility 29.7 INSL3 EPPIN CYP21A2 CYP11A1
5 adenoma 29.3 POMC MC2R CYP11B2 CYP11B1
6 conn's syndrome 28.8 POMC MC2R HSD3B2 CYP21A2 CYP11B2 CYP11B1
7 lipoid congenital adrenal hyperplasia 28.7 POMC MC2R INSL3 HSD3B2 HSD17B3 CYP21A2
8 familial glucocorticoid deficiency 28.5 POMC MC2R HSD3B2 CYP21A2 CYP11B2 CYP11B1
9 adrenal adenoma 28.4 POMC MC2R EPPIN CYP21A2 CYP11B2 CYP11B1
10 adrenal hyperplasia, congenital, due to 21-hydroxylase deficiency 10.4
11 posttransplant acute limbic encephalitis 10.3
12 azoospermia 10.2
13 testicular cancer 10.2
14 precocious puberty 10.2
15 hypoglycemic coma 10.1 POMC EPPIN
16 precocious puberty, male-limited 10.1 POMC CYP21A2
17 waterhouse-friderichsen syndrome 10.1 POMC MC2R
18 pituitary-dependent cushing's disease 10.1 POMC MC2R
19 corticosteroid-binding globulin deficiency 10.1 POMC MC2R
20 leiomyoma, uterine 10.1
21 down syndrome 10.1
22 adrenal hyperplasia, congenital, due to steroid 11-beta-hydroxylase deficiency 10.1
23 premature ovarian failure 7 10.1
24 leiomyoma 10.1
25 germinoma 10.1 POMC CYP21A2
26 glucocorticoid deficiency 1 10.1 POMC MC2R
27 mixed gonadal dysgenesis 10.1 HSD17B3 CYP21A2
28 cytochrome p450 oxidoreductase deficiency 10.1 HSD3B2 CYP21A2 CYP11B1
29 sebaceous gland disease 10.1 POMC CYP21A2
30 autoimmune polyendocrine syndrome, type i, with or without reversible metaphyseal dysplasia 10.1 CYP21A2 CYP11A1
31 aromatase excess syndrome 10.0 POMC EPPIN
32 intrauterine growth retardation, metaphyseal dysplasia, adrenal hypoplasia congenita, and genital anomalies 10.0 MC2R CYP11A1
33 adrenal hyperplasia, congenital, due to 3-beta-hydroxysteroid dehydrogenase 2 deficiency 10.0
34 glucocorticoid deficiency 4 with or without mineralocorticoid deficiency 10.0
35 rapidly involuting congenital hemangioma 10.0
36 male infertility 10.0
37 amenorrhea 10.0
38 nelson syndrome 10.0
39 adrenogenital syndrome 10.0
40 primary adrenal insufficiency 10.0
41 testicular torsion 10.0 INSL3 EPPIN
42 antley-bixler syndrome 9.9 POMC CYP21A2 CYP11A1
43 hypoaldosteronism 9.9 POMC CYP11B2
44 mccune-albright syndrome 9.9 POMC MC2R
45 complete androgen insensitivity syndrome 9.9 INSL3 HSD17B3
46 achalasia-addisonianism-alacrima syndrome 9.9 POMC MC2R CYP11A1
47 17-beta hydroxysteroid dehydrogenase iii deficiency 9.9 POMC HSD17B3 CYP11A1
48 persistent mullerian duct syndrome 9.8 INSL3 HSD17B3 CYP21A2
49 polycystic ovary syndrome 9.8 POMC HSD3B2 CYP21A2 CYP11A1
50 inguinal hernia 9.8 POMC INSL3 HSD17B3

Graphical network of the top 20 diseases related to Adrenal Rest Tumor:



Diseases related to Adrenal Rest Tumor

Symptoms & Phenotypes for Adrenal Rest Tumor

GenomeRNAi Phenotypes related to Adrenal Rest Tumor according to GeneCards Suite gene sharing:

25
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Reduced mammosphere formation GR00396-S 9.02 CYP11B1 CYP21A2 HSD3B2 MC2R POMC

MGI Mouse Phenotypes related to Adrenal Rest Tumor:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 9.97 CYP11A1 CYP11B1 CYP11B2 CYP21A2 EPPIN HSD17B3
2 endocrine/exocrine gland MP:0005379 9.86 CYP11A1 CYP11B1 CYP11B2 EPPIN HSD17B3 INSL3
3 adipose tissue MP:0005375 9.77 CYP11B1 CYP11B2 HSD17B3 MC2R POMC
4 immune system MP:0005387 9.76 CYP11A1 CYP11B1 CYP11B2 CYP21A2 EPPIN HSD17B3
5 reproductive system MP:0005389 9.5 CYP11A1 CYP11B1 CYP11B2 EPPIN HSD17B3 INSL3
6 hematopoietic system MP:0005397 9.23 CYP11A1 CYP11B1 CYP11B2 CYP21A2 EPPIN HSD17B3

Drugs & Therapeutics for Adrenal Rest Tumor

Search Clinical Trials, NIH Clinical Center for Adrenal Rest Tumor

Cochrane evidence based reviews: adrenal rest tumor

Genetic Tests for Adrenal Rest Tumor

Anatomical Context for Adrenal Rest Tumor

Organs/tissues related to Adrenal Rest Tumor:

MalaCards : Liver, Ovary, Hypothalamus, Testis, Pituitary

Publications for Adrenal Rest Tumor

Articles related to Adrenal Rest Tumor:

(show top 50) (show all 73)
# Title Authors PMID Year
1
Total adrenal volume but not testicular adrenal rest tumor volume is associated with hormonal control in patients with 21-hydroxylase deficiency. 53 62
20190160 2010
2
Origin of an ovarian steroid cell tumor causing isosexual pseudoprecocious puberty demonstrated by the expression of adrenal steroidogenic enzymes and adrenocorticotropin receptor. 53 62
10720064 2000
3
[A case report: reversible male infertility due to congenital adrenal hyperplasia]. 53 62
8258942 1993
4
Genotype of congenital adrenal hyperplasia patients with testicular adrenal rest tumor. 62
36343887 2022
5
Unilateral orchiectomy of a testicular adrenal rest tumor: Case report and review of management options. 62
36248778 2022
6
Congenital adrenal hyperplasia, disorders of sex development, and infertility in patients with POR gene pathogenic variants: a systematic review of the literature. 62
35842891 2022
7
Current status of transition medicine for 21-hydroxylase deficiency in Japan: from the perspective of pediatric endocrinologists. 62
34373418 2022
8
Genotype, Mortality, Morbidity, and Outcomes of 3β-Hydroxysteroid Dehydrogenase Deficiency in Algeria. 62
35757411 2022
9
Ovarian adrenal rest tumor in congenital adrenal hyperplasia: Is medical treatment the first line option? 62
34762785 2021
10
11-oxygenated androgens and their relation to hypothalamus-pituitary-gonadal-axis disturbances in adults with congenital adrenal hyperplasia. 62
34058329 2021
11
Incidental Finding of Bilateral Ovarian Adrenal Rest Tumor in a Patient With Congenital Adrenal Hyperplasia: A Case Report and Brief Review. 62
33433255 2021
12
Atypical Presentation of Testicular Adrenal Rest Tumor (TART) Leading to Bilateral Partial Orchiectomy in a 31-Year-Old Adult Revealing Primary Adrenal Insufficiency with CYP11A1 Deficiency. 62
34976419 2021
13
Morphologic and Molecular Characterization of Adrenals and Adrenal Rest Affected by Congenital Adrenal Hyperplasia. 62
34616364 2021
14
A spontaneous pregnancy and live birth in a woman with primary infertility following the excision of an ovarian adrenal rest tumor: A rare case. 62
33105528 2020
15
Usefulness of Modified CEUS LI-RADS for the Diagnosis of Hepatocellular Carcinoma Using Sonazoid. 62
33076435 2020
16
A case of Williams syndrome with suspected coexisting ectopic aldosterone-producing tumor in the liver. 62
33434178 2020
17
[Clinical characteristics of testicular adrenal rest tumor and factors associated with its occurrence in 21-hydroxylase deficiency patients]. 62
32575926 2020
18
Testicular adrenal rest tumor in the background of congenital adrenal hyperplasia 62
32323966 2020
19
An unusual epididymal localization of Testicular Adrenal Rest Tumor in an adolescent with congenital adrenal hyperplasia. 62
31227992 2019
20
Characterization of the CYP11A1 Nonsynonymous Variant p.E314K in Children Presenting With Adrenal Insufficiency. 62
30299480 2019
21
Testicular adrenal rest tumor without congenital adrenal hyperplasia: A rare case. 62
30041282 2018
22
Editorial Comment to Testicular adrenal rest tumor without congenital adrenal hyperplasia: A rare case. 62
30276892 2018
23
Prevalence, clinical characteristics and long-term outcomes of classical 11 β-hydroxylase deficiency (11BOHD) in Turkish population and novel mutations in CYP11B1 gene. 62
29626607 2018
24
Testicular adrenal rest tumors. 62
30300134 2018
25
An Interesting Case of Hepatic Adrenocortical Carcinoma. 62
30333277 2018
26
Testicular adrenal rest tumor screening and fertility counseling among males with congenital adrenal hyperplasia. 62
29330018 2018
27
Gonadal function in adult male patients with congenital adrenal hyperplasia. 62
29339528 2018
28
Two cases of reversible male infertility due to congenital adrenal hyperplasia combined with testicular adrenal rest tumor. 62
29371828 2018
29
Prevalence of Testicular Adrenal Rest Tumor and Factors Associated with Its Development in Congenital Adrenal Hyperplasia. 62
30149373 2018
30
Trails on 18F-Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography Leading to Diagnosis of Testicular Adrenal Rest Tumor. 62
29430117 2018
31
Testicular Adrenal Rest Tumor (TART) in congenital adrenal hyperplasia. 62
28676275 2017
32
Testicular Adrenal Rest Tumor in Two Brothers with a Novel Mutation in the 3-Beta-Hydroxysteroid Dehydrogenase-2 Gene. 62
27476613 2017
33
Testicular Adrenal Rest Tumors in Boys and Young Adults with Congenital Adrenal Hyperplasia. 62
27840017 2017
34
Adrenal Rest Tumor of the Liver Preoperatively Diagnosed as Hepatocellular Carcinoma. 62
28706747 2017
35
Clinical manifestations of testicular adrenal rest tumor in males with congenital adrenal hyperplasia. 62
26512352 2015
36
Combined adrenal failure and testicular adrenal rest tumor in a patient with nicotinamide nucleotide transhydrogenase deficiency. 62
25879317 2015
37
Profiles of 21-Carbon Steroids in 21-hydroxylase Deficiency. 62
25850025 2015
38
Hepatic adrenal rest tumor: Diagnostic pitfall and proposed algorithms to prevent misdiagnosis as lipid-rich hepatocellular carcinoma. 62
25572108 2015
39
[Diagnostic benefits of adrenocortical scintigraphy in hepatic adrenal rest tumor]. 62
25283230 2014
40
Testicular adrenal rest tumor in an adolescent with congenital adrenal hyperplasia, resolved by therapy doses adjustment. 62
24826980 2014
41
Testicular adrenal rest tumor in 11-Beta-hydroxylase deficiency driven congenital adrenal hyperplasia. 62
24741421 2014
42
Bilateral ovary adrenal rest tumor in a congenital adrenal hyperplasia following adrenalectomy. 62
24449659 2014
43
Testicular adrenal rest tumor mimicking leydig cell tumor in a patient with congenital adrenal hyperplasia. 62
24834391 2014
44
Testicular adrenal rest "tumor" or Leydig cell tumor? A report of a challenging case with literature review. 62
23984262 2013
45
Malignant adrenal rest tumor of the retroperitoneum producing adrenocortical steroids. 62
21374072 2011
46
Testicular adrenal rest tumor in infertile man with congenital adrenal hyperplasia: case report and literature review. 62
22069134 2011
47
The prevalence of testicular adrenal rest tumors and associated factors in postpubertal patients with congenital adrenal hyperplasia caused by 21-hydroxylase deficiency. 62
21521928 2011
48
[Bilateral testicular tumor in a young man with congenital 11β-hydroxylase deficiency]. 62
20980225 2010
49
Hepatic adrenal rest tumor mimicking hepatocellular carcinoma. 62
20924220 2010
50
Testicular adrenal rest tumor in a patient with 11beta-hydroxylase deficient congenital adrenal hyperplasia. 62
20857846 2010

Variations for Adrenal Rest Tumor

Expression for Adrenal Rest Tumor

Search GEO for disease gene expression data for Adrenal Rest Tumor.

Pathways for Adrenal Rest Tumor

Pathways related to Adrenal Rest Tumor according to GeneCards Suite gene sharing:

(show all 13)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.5 POMC HSD3B2 HSD17B3 CYP21A2 CYP11B2 CYP11B1
2
Show member pathways
13.43 POMC MC2R CYP21A2 CYP11B2 CYP11B1 CYP11A1
3
Show member pathways
12.71 POMC CYP21A2 CYP11B2 CYP11B1 CYP11A1
4
Show member pathways
12.49 CYP11A1 CYP11B1 CYP11B2 CYP21A2 MC2R POMC
5
Show member pathways
12.47 POMC CYP21A2 CYP11B2 CYP11B1 CYP11A1
6
Show member pathways
12.06 POMC HSD3B2 HSD17B3 CYP21A2 CYP11B2 CYP11B1
7
Show member pathways
11.89 POMC MC2R INSL3
8 11.51 POMC HSD3B2 CYP21A2 CYP11B1 CYP11A1
9
Show member pathways
11.37 HSD3B2 HSD17B3 CYP11B1
10
Show member pathways
11.15 POMC HSD3B2 HSD17B3 CYP21A2 CYP11B2 CYP11B1
11 11.09 CYP21A2 CYP11B2 CYP11B1 CYP11A1
12 10.62 HSD3B2 HSD17B3 CYP11A1
13
Show member pathways
10.4 HSD3B2 CYP11B2 CYP11A1

GO Terms for Adrenal Rest Tumor

Biological processes related to Adrenal Rest Tumor according to GeneCards Suite gene sharing:

(show all 17)
# Name GO ID Score Top Affiliating Genes
1 cholesterol metabolic process GO:0008203 10.01 CYP11B2 CYP11B1 CYP11A1
2 lipid metabolic process GO:0006629 9.91 HSD3B2 HSD17B3 CYP21A2 CYP11B2 CYP11B1 CYP11A1
3 cellular response to hormone stimulus GO:0032870 9.87 CYP11B2 CYP11B1
4 positive regulation of cAMP-mediated signaling GO:0043950 9.86 POMC INSL3
5 cellular response to potassium ion GO:0035865 9.85 CYP11B2 CYP11B1
6 cellular response to peptide hormone stimulus GO:0071375 9.85 CYP11B2 CYP11B1 CYP11A1
7 androgen biosynthetic process GO:0006702 9.83 HSD3B2 HSD17B3
8 cortisol biosynthetic process GO:0034651 9.8 CYP11B2 CYP11B1
9 steroid metabolic process GO:0008202 9.8 CYP11A1 CYP11B1 CYP11B2 CYP21A2
10 C21-steroid hormone biosynthetic process GO:0006700 9.8 CYP11B2 CYP11B1 CYP11A1
11 aldosterone biosynthetic process GO:0032342 9.78 CYP11B2 CYP11B1
12 mineralocorticoid biosynthetic process GO:0006705 9.76 CYP21A2 CYP11B2
13 sterol metabolic process GO:0016125 9.76 CYP11A1 CYP11B1 CYP11B2 CYP21A2
14 cortisol metabolic process GO:0034650 9.73 CYP11B2 CYP11B1 CYP11A1
15 C21-steroid hormone metabolic process GO:0008207 9.69 CYP11A1 HSD3B2
16 glucocorticoid biosynthetic process GO:0006704 9.56 CYP21A2 CYP11B2 CYP11B1 CYP11A1
17 steroid biosynthetic process GO:0006694 9.28 HSD3B2 HSD17B3 CYP21A2 CYP11B2 CYP11B1 CYP11A1

Molecular functions related to Adrenal Rest Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 heme binding GO:0020037 10.01 CYP21A2 CYP11B2 CYP11B1 CYP11A1
2 iron ion binding GO:0005506 9.97 CYP21A2 CYP11B2 CYP11B1 CYP11A1
3 steroid hydroxylase activity GO:0008395 9.73 CYP21A2 CYP11B2
4 steroid 11-beta-monooxygenase activity GO:0004507 9.62 CYP11B1 CYP11B2
5 corticosterone 18-monooxygenase activity GO:0047783 9.56 CYP11B1 CYP11B2
6 oxidoreductase activity GO:0016491 9.5 HSD3B2 HSD17B3 CYP21A2 CYP11B2 CYP11B1 CYP11A1
7 monooxygenase activity GO:0004497 9.46 CYP21A2 CYP11B2 CYP11B1 CYP11A1
8 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen GO:0016705 8.92 CYP21A2 CYP11B2 CYP11B1 CYP11A1

Sources for Adrenal Rest Tumor

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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