MCID: ADR001
MIFTS: 29

Adrenal Rest Tumor

Categories: Cancer diseases, Endocrine diseases

Aliases & Classifications for Adrenal Rest Tumor

MalaCards integrated aliases for Adrenal Rest Tumor:

Name: Adrenal Rest Tumor 12 56 45 15 17 74
Adrenal Rest Neoplasm 12

Classifications:



External Ids:

Disease Ontology 12 DOID:1786
MeSH 45 D000314
NCIt 51 C2860
SNOMED-CT 69 54292009
UMLS 74 C0001630

Summaries for Adrenal Rest Tumor

MalaCards based summary : Adrenal Rest Tumor, also known as adrenal rest neoplasm, is related to leydig cell tumor and lipoid congenital adrenal hyperplasia. An important gene associated with Adrenal Rest Tumor is CYP21A2 (Cytochrome P450 Family 21 Subfamily A Member 2), and among its related pathways/superpathways are Aldosterone synthesis and secretion and Corticotropin-releasing hormone signaling pathway. Affiliated tissues include ovary, liver and pituitary, and related phenotype is Synthetic lethal with Ras.

Related Diseases for Adrenal Rest Tumor

Graphical network of the top 20 diseases related to Adrenal Rest Tumor:



Diseases related to Adrenal Rest Tumor

Symptoms & Phenotypes for Adrenal Rest Tumor

GenomeRNAi Phenotypes related to Adrenal Rest Tumor according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with Ras GR00018-A-0 8.92 CYP11B1 HSD3B2 NNT NR5A1

Drugs & Therapeutics for Adrenal Rest Tumor

Search Clinical Trials , NIH Clinical Center for Adrenal Rest Tumor

Cochrane evidence based reviews: adrenal rest tumor

Genetic Tests for Adrenal Rest Tumor

Anatomical Context for Adrenal Rest Tumor

MalaCards organs/tissues related to Adrenal Rest Tumor:

42
Ovary, Liver, Pituitary

Publications for Adrenal Rest Tumor

Articles related to Adrenal Rest Tumor:

(show all 37)
# Title Authors Year
1
Testicular adrenal rest tumor screening and fertility counseling among males with congenital adrenal hyperplasia. ( 29330018 )
2018
2
Two cases of reversible male infertility due to congenital adrenal hyperplasia combined with testicular adrenal rest tumor. ( 29371828 )
2018
3
Trails on 18F-Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography Leading to Diagnosis of Testicular Adrenal Rest Tumor. ( 29430117 )
2018
4
Testicular adrenal rest tumor without congenital adrenal hyperplasia: A rare case. ( 30041282 )
2018
5
Prevalence of Testicular Adrenal Rest Tumor and Factors Associated with Its Development in Congenital Adrenal Hyperplasia. ( 30149373 )
2018
6
Editorial Comment to Testicular adrenal rest tumor without congenital adrenal hyperplasia: A rare case. ( 30276892 )
2018
7
Testicular Adrenal Rest Tumor in Two Brothers with a Novel Mutation in the 3-Beta-Hydroxysteroid Dehydrogenase-2 Gene. ( 27476613 )
2017
8
Testicular Adrenal Rest Tumor (TART) in congenital adrenal hyperplasia. ( 28676275 )
2017
9
Adrenal Rest Tumor of the Liver Preoperatively Diagnosed as Hepatocellular Carcinoma. ( 28706747 )
2017
10
Hepatic adrenal rest tumor: Diagnostic pitfall and proposed algorithms to prevent misdiagnosis as lipid-rich hepatocellular carcinoma. ( 25572108 )
2015
11
Combined adrenal failure and testicular adrenal rest tumor in a patient with nicotinamide nucleotide transhydrogenase deficiency. ( 25879317 )
2015
12
Clinical manifestations of testicular adrenal rest tumor in males with congenital adrenal hyperplasia. ( 26512352 )
2015
13
Bilateral ovary adrenal rest tumor in a congenital adrenal hyperplasia following adrenalectomy. ( 24449659 )
2014
14
Testicular adrenal rest tumor in 11-Beta-hydroxylase deficiency driven congenital adrenal hyperplasia. ( 24741421 )
2014
15
Testicular adrenal rest tumor in an adolescent with congenital adrenal hyperplasia, resolved by therapy doses adjustment. ( 24826980 )
2014
16
Testicular adrenal rest tumor mimicking leydig cell tumor in a patient with congenital adrenal hyperplasia. ( 24834391 )
2014
17
[Diagnostic benefits of adrenocortical scintigraphy in hepatic adrenal rest tumor]. ( 25283230 )
2014
18
Testicular adrenal rest "tumor" or Leydig cell tumor? A report of a challenging case with literature review. ( 23984262 )
2013
19
Malignant adrenal rest tumor of the retroperitoneum producing adrenocortical steroids. ( 21374072 )
2011
20
Testicular adrenal rest tumor in infertile man with congenital adrenal hyperplasia: case report and literature review. ( 22069134 )
2011
21
Total adrenal volume but not testicular adrenal rest tumor volume is associated with hormonal control in patients with 21-hydroxylase deficiency. ( 20190160 )
2010
22
Ovarian adrenal rest tumor in a congenital adrenal hyperplasia patient with adrenocorticotropin hypersecretion following adrenalectomy. ( 20431278 )
2010
23
Testicular adrenal rest tumor in a patient with 11beta-hydroxylase deficient congenital adrenal hyperplasia. ( 20857846 )
2010
24
Hepatic adrenal rest tumor mimicking hepatocellular carcinoma. ( 20924220 )
2010
25
A case of adrenal rest tumor of the liver: Radiological imaging and immunohistochemical study of steroidogenic enzymes. ( 18564144 )
2008
26
Nonfunctioning adrenal rest tumor of the liver: radiologic appearance. ( 11176302 )
2001
27
Adrenal rest tumor of the liver: a case report with immunohistochemical investigation of steroidogenesis. ( 10792789 )
2000
28
Adrenal rest tumor of the broad ligament: case report with immunohistochemical study of steroidogenic enzymes. ( 9234389 )
1997
29
Adrenal rest tumor of the liver causing Cushing's syndrome: treatment with ketoconazole preceding an apparent surgical cure. ( 3964792 )
1985
30
Primary testicular abnormalities causing precocious puberty Leydig cell tumor, Leydig cell hyperplasia, and adrenal rest tumor. ( 6226233 )
1983
31
Endocrine studies in a patient with functioning adrenal rest tumor of the liver. ( 7234878 )
1981
32
Virilizing adrenal rest tumor of the ovary--a clinicomorphological study. ( 214297 )
1978
33
Fertility following treatment of adrenal rest tumor. ( 617541 )
1977
34
In vivo endocrine studies in adrenal rest tumor of ovary. ( 4277531 )
1974
35
Adrenal rest tumor of the liver. ( 14405693 )
1960
36
Ovarian adrenal rest tumor (masculinovoblastoma) simulating adrenal virilism; report of a case with hormone studies. ( 13469882 )
1957
37
Masculinovoblastoma or masculinizing adrenal rest tumor of ovary; report of a case. ( 14888529 )
1952

Variations for Adrenal Rest Tumor

Expression for Adrenal Rest Tumor

Search GEO for disease gene expression data for Adrenal Rest Tumor.

Pathways for Adrenal Rest Tumor

GO Terms for Adrenal Rest Tumor

Cellular components related to Adrenal Rest Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 mitochondrial membrane GO:0031966 8.96 CYP11B1 HSD3B2
2 mitochondrial inner membrane GO:0005743 8.8 CYP11B1 HSD3B2 NNT

Biological processes related to Adrenal Rest Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 oxidation-reduction process GO:0055114 9.56 CYP11B1 CYP21A2 HSD3B2 NNT
2 steroid metabolic process GO:0008202 9.37 CYP11B1 CYP21A2
3 sterol metabolic process GO:0016125 9.32 CYP11B1 CYP21A2
4 mineralocorticoid biosynthetic process GO:0006705 9.16 CYP21A2 HSD3B2
5 steroid biosynthetic process GO:0006694 9.13 CYP11B1 CYP21A2 HSD3B2
6 glucocorticoid biosynthetic process GO:0006704 8.8 CYP11B1 CYP21A2 HSD3B2

Molecular functions related to Adrenal Rest Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 heme binding GO:0020037 9.26 CYP11B1 CYP21A2
2 iron ion binding GO:0005506 9.16 CYP11B1 CYP21A2
3 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen GO:0016705 8.96 CYP11B1 CYP21A2
4 oxidoreductase activity GO:0016491 8.92 CYP11B1 CYP21A2 HSD3B2 NNT

Sources for Adrenal Rest Tumor

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75 UMLS via Orphanet
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