MCID: ADR001
MIFTS: 35

Adrenal Rest Tumor

Categories: Cancer diseases, Endocrine diseases

Aliases & Classifications for Adrenal Rest Tumor

MalaCards integrated aliases for Adrenal Rest Tumor:

Name: Adrenal Rest Tumor 12 55 44 15 73
Adrenal Rest Neoplasm 12

Classifications:



External Ids:

Disease Ontology 12 DOID:1786
MeSH 44 D000314
NCIt 50 C2860
SNOMED-CT 68 54292009
UMLS 73 C0001630

Summaries for Adrenal Rest Tumor

MalaCards based summary : Adrenal Rest Tumor, also known as adrenal rest neoplasm, is related to conn's syndrome and lipoid congenital adrenal hyperplasia. An important gene associated with Adrenal Rest Tumor is CYP21A2 (Cytochrome P450 Family 21 Subfamily A Member 2), and among its related pathways/superpathways are Metabolism and Aldosterone synthesis and secretion. Affiliated tissues include liver, ovary and pituitary, and related phenotypes are Reduced mammosphere formation and nervous system

Related Diseases for Adrenal Rest Tumor

Diseases related to Adrenal Rest Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 76)
# Related Disease Score Top Affiliating Genes
1 conn's syndrome 29.3 CYP11B1 CYP11B2 CYP21A2 MC2R POMC
2 lipoid congenital adrenal hyperplasia 29.1 CYP11B1 CYP11B2 CYP21A2 HSD3B1 HSD3B2 MC2R
3 3-beta-hydroxysteroid dehydrogenase deficiency 10.9 CYP21A2 HSD3B2
4 classic congenital adrenal hyperplasia due to 21-hydroxylase deficiency 10.9 CYP21A2 POMC
5 acute adrenal insufficiency 10.8 CYP21A2 POMC
6 cytochrome p450 oxidoreductase deficiency 10.8 CYP21A2 POMC
7 glucocorticoid deficiency 1 10.8 MC2R POMC
8 aldosterone-producing adenoma 10.7 CYP11B2 CYP21A2
9 adrenal cortical hypofunction 10.6 CYP21A2 NR5A1 POMC
10 hypoaldosteronism 10.6 CYP11B2 POMC
11 phagocyte bactericidal dysfunction 10.6 DUOX1 DUOX2
12 hypoadrenocorticism, familial 10.6 CYP21A2 MC2R POMC
13 testicular leydig cell tumor 10.5 CYP21A2 HSD3B1 POMC
14 achalasia-addisonianism-alacrima syndrome 10.5 MC2R NNT POMC
15 familial glucocorticoid deficiency 10.5 MC2R NNT POMC
16 hyperaldosteronism, familial, type i 10.4 CYP11B1 CYP11B2 POMC
17 sella turcica neoplasm 10.4 POMC SYP
18 pituitary infarct 10.4 GNRH1 POMC
19 adrenal cortex disease 10.4 CYP11B1 CYP11B2 POMC
20 adrenal gland disease 10.4 CYP11B1 CYP11B2 POMC
21 endocrine organ benign neoplasm 10.4 CYP11B1 CYP11B2 POMC
22 tuberculum sellae meningioma 10.3 POMC SYP
23 hypothalamic disease 10.3 GNRH1 POMC
24 familial hyperaldosteronism 10.3 CYP11B1 CYP11B2
25 chiasmal syndrome 10.3 GNRH1 POMC
26 pituitary apoplexy 10.3 GNRH1 POMC
27 esophageal neuroendocrine tumor 10.2 NCAM1 SYP
28 empty sella syndrome 10.2 GNRH1 POMC
29 ovarian large-cell neuroendocrine carcinoma 10.2 NCAM1 SYP
30 lung combined type small cell carcinoma 10.2 NCAM1 SYP
31 sensory organ benign neoplasm 10.2 NCAM1 SYP
32 gallbladder small cell carcinoma 10.2 NCAM1 SYP
33 cutaneous ganglioneuroma 10.2 NCAM1 SYP
34 extrahepatic bile duct adenocarcinoma 10.2 NCAM1 SYP
35 orbital cancer 10.1 NCAM1 SYP
36 sex differentiation disease 10.1 CYP21A2 GNRH1 POMC
37 polycystic ovary syndrome 10.1 CYP21A2 GNRH1 HSD3B2
38 sertoli cell tumor 10.1 NR5A1 SYP
39 hypoganglionosis 10.1 NCAM1 SYP
40 gonadal disease 10.1 GNRH1 NR5A1 POMC
41 pancreatic endocrine carcinoma 10.1 NCAM1 SYP
42 female reproductive system disease 10.1 GNRH1 NR5A1 POMC
43 amenorrhea 10.1 GNRH1 NR5A1 POMC
44 pancreatic serous cystadenoma 10.1 NCAM1 SYP
45 conventional angiosarcoma 10.1 NCAM1 SYP
46 adrenal hyperplasia, congenital, due to 21-hydroxylase deficiency 10.0
47 infertility 10.0
48 supratentorial primitive neuroectodermal tumor 10.0 NCAM1 SYP
49 endometrial small cell carcinoma 10.0 NCAM1 SYP
50 cell type benign neoplasm 10.0 CYP11B2 POMC SYP

Graphical network of the top 20 diseases related to Adrenal Rest Tumor:



Diseases related to Adrenal Rest Tumor

Symptoms & Phenotypes for Adrenal Rest Tumor

GenomeRNAi Phenotypes related to Adrenal Rest Tumor according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Reduced mammosphere formation GR00396-S 9.17 CYP11B1 CYP21A2 HSD3B2 MC2R NCAM1 PLK1

MGI Mouse Phenotypes related to Adrenal Rest Tumor:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 nervous system MP:0003631 9.28 ARG1 CYP11B2 DUOX2 GNRH1 MC2R NCAM1

Drugs & Therapeutics for Adrenal Rest Tumor

Search Clinical Trials , NIH Clinical Center for Adrenal Rest Tumor

Cochrane evidence based reviews: adrenal rest tumor

Genetic Tests for Adrenal Rest Tumor

Anatomical Context for Adrenal Rest Tumor

MalaCards organs/tissues related to Adrenal Rest Tumor:

41
Liver, Ovary, Pituitary, Testis

Publications for Adrenal Rest Tumor

Articles related to Adrenal Rest Tumor:

(show all 47)
# Title Authors Year
1
Trails on<sup>18</sup>F-Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography Leading to Diagnosis of Testicular Adrenal Rest Tumor. ( 29430117 )
2018
2
Two cases of reversible male infertility due to congenital adrenal hyperplasia combined with testicular adrenal rest tumor. ( 29371828 )
2018
3
Testicular Adrenal Rest Tumor (TART) in congenital adrenal hyperplasia. ( 28676275 )
2017
4
Testicular adrenal rest tumors in congenital adrenal hyperplasia-cross-sectional study of 51 Croatian male patients. ( 28879515 )
2017
5
Testicular Adrenal Rests Tumors and Testicular Microlithiasis in a Brazilian Case Series with Classic Congenital Adrenal Hyperplasia. ( 28835760 )
2017
6
Adrenal Rest Tumor of the Liver Preoperatively Diagnosed as Hepatocellular Carcinoma. ( 28706747 )
2017
7
Testicular adrenal rest tumor screening and fertility counseling among males with congenital adrenal hyperplasia. ( 29330018 )
2017
8
Testicular Adrenal Rest Tumor In Brothers With Novel Mutation In 3-Beta Hydroxysteroid Dehydrogenase -2 Gene. ( 27476613 )
2016
9
Ovarian Adrenal Rest Tumors Undetected by Imaging Studies and Identified at Surgery in Three Females with Congenital Adrenal Hyperplasia Unresponsive to Increased Hormone Therapy Dosage. ( 28032206 )
2016
10
Molecular characterization of testicular adrenal rest tumors in congenital adrenal hyperplasia: lesions with both adrenocortical and Leydig cell features. ( 25485724 )
2015
11
Combined adrenal failure and testicular adrenal rest tumor in a patient with nicotinamide nucleotide transhydrogenase deficiency. ( 25879317 )
2015
12
Hepatic adrenal rest tumor: Diagnostic pitfall and proposed algorithms to prevent misdiagnosis as lipid-rich hepatocellular carcinoma. ( 25572108 )
2015
13
Clinical manifestations of testicular adrenal rest tumor in males with congenital adrenal hyperplasia. ( 26512352 )
2015
14
131I-Noriodocholesterol Uptake by Testicular Adrenal Rest Tumors in a Patient With Classical 21-Hydroxylase Deficiency. ( 25121463 )
2014
15
Bilateral ovary adrenal rest tumor in a congenital adrenal hyperplasia following adrenalectomy. ( 24449659 )
2014
16
Diagnostic benefits of adrenocortical scintigraphy in hepatic adrenal rest tumor. ( 25283230 )
2014
17
Testicular adrenal rest tumor in an adolescent with congenital adrenal hyperplasia, resolved by therapy doses adjustment. ( 24826980 )
2014
18
Testicular adrenal rest tumor in 11-Beta-hydroxylase deficiency driven congenital adrenal hyperplasia. ( 24741421 )
2014
19
Testicular adrenal rest tumor mimicking leydig cell tumor in a patient with congenital adrenal hyperplasia. ( 24834391 )
2014
20
Testicular adrenal rest tumors develop independently of long-term disease control: a longitudinal analysis of 50 adult men with congenital adrenal hyperplasia due to classic 21-hydroxylase deficiency. ( 23969190 )
2013
21
Testicular adrenal rest tumors (TARTs) as a male infertility factor. Case report. ( 23342900 )
2012
22
Leydig Cell Tumor Associated with Testicular Adrenal Rest Tumors in a Patient with Congenital Adrenal Hyperplasia due to 11I^-Hydroxylase Deficiency. ( 22606635 )
2012
23
Testicular adrenal rest tumor in infertile man with congenital adrenal hyperplasia: case report and literature review. ( 22069134 )
2011
24
Malignant adrenal rest tumor of the retroperitoneum producing adrenocortical steroids. ( 21374072 )
2011
25
The prevalence of testicular adrenal rest tumors and associated factors in postpubertal patients with congenital adrenal hyperplasia caused by 21-hydroxylase deficiency. ( 21521928 )
2011
26
Prevalence of testicular microlithiasis in males with congenital adrenal hyperplasia and its association with testicular adrenal rest tumors. ( 20407230 )
2010
27
Reversal of primary male infertility and testicular adrenal rest tumors in salt-wasting congenital adrenal hyperplasia. ( 20444929 )
2010
28
Testicular adrenal rest tumor in a patient with 11beta-hydroxylase deficient congenital adrenal hyperplasia. ( 20857846 )
2010
29
Ovarian adrenal rest tumor in a congenital adrenal hyperplasia patient with adrenocorticotropin hypersecretion following adrenalectomy. ( 20431278 )
2010
30
Hepatic adrenal rest tumor mimicking hepatocellular carcinoma. ( 20924220 )
2010
31
Total adrenal volume but not testicular adrenal rest tumor volume is associated with hormonal control in patients with 21-hydroxylase deficiency. ( 20190160 )
2010
32
A case of adrenal rest tumor of the liver: Radiological imaging and immunohistochemical study of steroidogenic enzymes. ( 18564144 )
2008
33
Testicular adrenal rest tumors in adult males with congenital adrenal hyperplasia: evaluation of pituitary-gonadal function before and after successful testis-sparing surgery in eight patients. ( 17090637 )
2007
34
Testicular adrenal rest tumors and Leydig and Sertoli cell function in boys with classical congenital adrenal hyperplasia. ( 17895312 )
2007
35
High prevalence of testicular adrenal rest tumors, impaired spermatogenesis, and Leydig cell failure in adolescent and adult males with congenital adrenal hyperplasia. ( 11739428 )
2001
36
Nonfunctioning adrenal rest tumor of the liver: radiologic appearance. ( 11176302 )
2001
37
Adrenal rest tumor of the liver: a case report with immunohistochemical investigation of steroidogenesis. ( 10792789 )
2000
38
Adrenal rest tumor of the broad ligament: case report with immunohistochemical study of steroidogenic enzymes. ( 9234389 )
1997
39
Adrenal rest tumor of the liver causing Cushing's syndrome: treatment with ketoconazole preceding an apparent surgical cure. ( 3964792 )
1985
40
Primary testicular abnormalities causing precocious puberty Leydig cell tumor, Leydig cell hyperplasia, and adrenal rest tumor. ( 6226233 )
1983
41
Endocrine studies in a patient with functioning adrenal rest tumor of the liver. ( 7234878 )
1981
42
Virilizing adrenal rest tumor of the ovary--a clinicomorphological study. ( 214297 )
1978
43
Fertility following treatment of adrenal rest tumor. ( 617541 )
1977
44
In vivo endocrine studies in adrenal rest tumor of ovary. ( 4277531 )
1974
45
Adrenal rest tumor of the liver. ( 14405693 )
1960
46
Ovarian adrenal rest tumor (masculinovoblastoma) simulating adrenal virilism; report of a case with hormone studies. ( 13469882 )
1957
47
Masculinovoblastoma or masculinizing adrenal rest tumor of ovary; report of a case. ( 14888529 )
1952

Variations for Adrenal Rest Tumor

Expression for Adrenal Rest Tumor

Search GEO for disease gene expression data for Adrenal Rest Tumor.

Pathways for Adrenal Rest Tumor

Pathways related to Adrenal Rest Tumor according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.73 ARG1 CYP11B1 CYP11B2 CYP21A2 DUOX1 DUOX2
2
Show member pathways
12.47 CYP11B1 CYP11B2 CYP21A2 DUOX2 HSD3B1 HSD3B2
3 11.62 CYP11B1 CYP21A2 HSD3B1 HSD3B2 POMC
4
Show member pathways
11.37 CYP11B1 CYP11B2 CYP21A2 HSD3B1 HSD3B2
5
Show member pathways
11.28 CYP11B1 HSD3B1 HSD3B2
6
Show member pathways
11.04 CYP11B1 CYP11B2 CYP21A2 HSD3B1 HSD3B2 POMC
7
Show member pathways
10.82 CYP11B1 CYP11B2 CYP21A2

GO Terms for Adrenal Rest Tumor

Cellular components related to Adrenal Rest Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 mitochondrial inner membrane GO:0005743 9.55 CYP11B1 CYP11B2 HSD3B1 HSD3B2 NNT
2 smooth endoplasmic reticulum membrane GO:0030868 8.96 HSD3B1 HSD3B2
3 mitochondrial membrane GO:0031966 8.92 CYP11B1 CYP11B2 HSD3B1 HSD3B2

Biological processes related to Adrenal Rest Tumor according to GeneCards Suite gene sharing:

(show all 23)
# Name GO ID Score Top Affiliating Genes
1 oxidation-reduction process GO:0055114 9.86 CYP11B1 CYP11B2 CYP21A2 DUOX1 DUOX2 HSD3B1
2 steroid metabolic process GO:0008202 9.77 CYP11B1 CYP11B2 CYP21A2
3 cellular response to peptide hormone stimulus GO:0071375 9.61 CYP11B1 CYP11B2
4 hydrogen peroxide catabolic process GO:0042744 9.61 DUOX1 DUOX2
5 hormone metabolic process GO:0042445 9.59 DUOX2 NR5A1
6 C21-steroid hormone biosynthetic process GO:0006700 9.58 CYP11B1 CYP11B2
7 thyroid hormone generation GO:0006590 9.58 DUOX1 DUOX2
8 hormone biosynthetic process GO:0042446 9.57 DUOX1 DUOX2
9 small molecule metabolic process GO:0044281 9.56 CYP11B1 CYP11B2
10 androgen biosynthetic process GO:0006702 9.55 HSD3B1 HSD3B2
11 steroid biosynthetic process GO:0006694 9.55 CYP11B1 CYP11B2 CYP21A2 HSD3B1 HSD3B2
12 cellular response to potassium ion GO:0035865 9.54 CYP11B1 CYP11B2
13 hydrogen peroxide biosynthetic process GO:0050665 9.52 DUOX1 DUOX2
14 secondary metabolite biosynthetic process GO:0044550 9.51 CYP11B1 CYP11B2
15 sterol metabolic process GO:0016125 9.5 CYP11B1 CYP11B2 CYP21A2
16 dehydroaustinol biosynthetic process GO:1900563 9.49 CYP11B1 CYP11B2
17 cortisol metabolic process GO:0034650 9.48 CYP11B1 CYP11B2
18 aldosterone biosynthetic process GO:0032342 9.46 CYP11B1 CYP11B2
19 austinol biosynthetic process GO:1900560 9.43 CYP11B1 CYP11B2
20 cortisol biosynthetic process GO:0034651 9.4 CYP11B1 CYP11B2
21 cuticle development GO:0042335 9.37 DUOX1 DUOX2
22 mineralocorticoid biosynthetic process GO:0006705 9.26 CYP11B2 CYP21A2 HSD3B1 HSD3B2
23 glucocorticoid biosynthetic process GO:0006704 9.02 CYP11B1 CYP11B2 CYP21A2 HSD3B1 HSD3B2

Molecular functions related to Adrenal Rest Tumor according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 iron ion binding GO:0005506 9.69 CYP11B1 CYP11B2 CYP21A2
2 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen GO:0016705 9.63 CYP11B1 CYP11B2 CYP21A2
3 peroxidase activity GO:0004601 9.49 DUOX1 DUOX2
4 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen GO:0016709 9.48 CYP11B1 CYP11B2
5 NAD(P)H oxidase activity GO:0016174 9.43 DUOX1 DUOX2
6 3-beta-hydroxy-delta5-steroid dehydrogenase activity GO:0003854 9.4 HSD3B1 HSD3B2
7 steroid delta-isomerase activity GO:0004769 9.37 HSD3B1 HSD3B2
8 heme binding GO:0020037 9.35 CYP11B1 CYP11B2 CYP21A2 DUOX1 DUOX2
9 corticosterone 18-monooxygenase activity GO:0047783 9.32 CYP11B1 CYP11B2
10 steroid 11-beta-monooxygenase activity GO:0004507 9.26 CYP11B1 CYP11B2
11 oxidoreductase activity GO:0016491 9.23 CYP11B1 CYP11B2 CYP21A2 DUOX1 DUOX2 HSD3B1
12 cholesterol dehydrogenase activity GO:0102294 9.16 HSD3B1 HSD3B2

Sources for Adrenal Rest Tumor

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
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57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
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