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MCID: ADR001
MIFTS: 31

Adrenal Rest Tumor

Categories: Cancer diseases, Endocrine diseases
Genes Tissues Related diseases Publications Pathways
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Aliases & Classifications for Adrenal Rest Tumor

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MalaCards integrated aliases for Adrenal Rest Tumor:

Name: Adrenal Rest Tumor 12 54 44 15 17 70
Adrenal Rest Neoplasm 12

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Endocrine diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:1786
MeSH 44 D000314
NCIt 50 C2860
SNOMED-CT 67 54292009
UMLS 70 C0001630
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Summaries for Adrenal Rest Tumor

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MalaCards based summary : Adrenal Rest Tumor, also known as adrenal rest neoplasm, is related to acute adrenal insufficiency and luteoma. An important gene associated with Adrenal Rest Tumor is CYP21A2 (Cytochrome P450 Family 21 Subfamily A Member 2), and among its related pathways/superpathways are Aldosterone synthesis and secretion and G alpha (s) signalling events. Affiliated tissues include ovary, testis and cortex, and related phenotypes are Reduced mammosphere formation and endocrine/exocrine gland

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Related Diseases for Adrenal Rest Tumor

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Diseases related to Adrenal Rest Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 79)
# Related Disease Score Top Affiliating Genes
1 acute adrenal insufficiency 30.2 POMC CYP21A2
2 luteoma 30.2 EPPIN CYP21A2
3 leydig cell tumor 30.0 NR5A1 INSL3 CYP21A2
4 infertility 29.7 NR5A1 INSL3 EPPIN CYP21A2
5 adenoma 29.4 POMC CYP21A2 CYP11B2 CYP11B1
6 lipoid congenital adrenal hyperplasia 29.3 POMC NR5A1 MC2R HSD3B2 CYP21A2 CYP11B2
7 male infertility 29.1 NR5A1 INSL3 EPPIN CYP21A2
8 adrenal adenoma 29.0 POMC MC2R CYP21A2 CYP11B2 CYP11B1
9 familial glucocorticoid deficiency 28.4 POMC NR5A1 MC2R HSD3B2 CYP21A2 CYP11B2
10 adrenal hyperplasia, congenital, due to 21-hydroxylase deficiency 10.4
11 posttransplant acute limbic encephalitis 10.3
12 3-beta-hydroxysteroid dehydrogenase deficiency 10.2 HSD3B2 CYP21A2
13 azoospermia 10.2
14 precocious puberty 10.2
15 cytochrome p450 oxidoreductase deficiency 10.2 POMC CYP21A2
16 classic congenital adrenal hyperplasia due to 21-hydroxylase deficiency 10.2 POMC CYP21A2
17 sebaceous gland disease 10.1 POMC CYP21A2
18 hepatocellular carcinoma 10.1
19 leiomyoma, uterine 10.1
20 leiomyoma 10.1
21 sexual disorder 10.1 POMC EPPIN
22 ovarian sex-cord stromal tumor 10.1 NR5A1 EPPIN
23 precocious puberty, male-limited 10.1 POMC CYP21A2
24 mixed gonadal dysgenesis 10.1 NR5A1 CYP21A2
25 aldosterone-producing adenoma 10.1 CYP21A2 CYP11B2
26 antley-bixler syndrome 10.1 POMC CYP21A2
27 corticosteroid-binding globulin deficiency 10.1 POMC MC2R
28 adrenal insufficiency, congenital, with 46,xy sex reversal, partial or complete 10.1 POMC HSD3B2 CYP21A2
29 hypoaldosteronism 10.1 POMC CYP11B2
30 glucocorticoid deficiency 1 10.1 POMC MC2R
31 pseudohyperkalemia, familial, 2, due to red cell leak 10.0 CYP21A2 CYP11B2
32 sex cord-gonadal stromal tumor 10.0 POMC NR5A1
33 acth-secreting pituitary adenoma 10.0 POMC MC2R
34 familial hyperaldosteronism 10.0 CYP11B2 CYP11B1
35 cortisone reductase deficiency 10.0 POMC HSD17B3 CYP21A2
36 gynecomastia 10.0 POMC HSD17B3 CYP21A2
37 apparent mineralocorticoid excess 10.0 CYP11B2 CYP11B1
38 testicular leydig cell tumor 10.0 INSL3 CYP21A2
39 dowling-degos disease 1 10.0
40 glucocorticoid deficiency 4 with or without mineralocorticoid deficiency 10.0
41 rapidly involuting congenital hemangioma 10.0
42 waterhouse-friderichsen syndrome 9.9 POMC MC2R CYP21A2
43 intrauterine growth retardation, metaphyseal dysplasia, adrenal hypoplasia congenita, and genital anomalies 9.9 NR5A1 MC2R
44 acth-independent macronodular adrenal hyperplasia 9.9 POMC MC2R
45 pseudohypoaldosteronism, type i, autosomal recessive 9.9 MC2R HSD3B2 CYP11B1
46 aromatase excess syndrome 9.9 POMC NR5A1 EPPIN
47 testicular torsion 9.9 INSL3 EPPIN
48 achalasia-addisonianism-alacrima syndrome 9.9 POMC MC2R CYP11B1
49 carney complex variant 9.9 POMC MC2R CYP11B1
50 pelvic varices 9.9 INSL3 EPPIN

Graphical network of the top 20 diseases related to Adrenal Rest Tumor:



Diseases related to Adrenal Rest Tumor
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Symptoms & Phenotypes for Adrenal Rest Tumor

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GenomeRNAi Phenotypes related to Adrenal Rest Tumor according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Reduced mammosphere formation GR00396-S 9.02 CYP11B1 CYP21A2 HSD3B2 MC2R POMC

MGI Mouse Phenotypes related to Adrenal Rest Tumor:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 9.17 CYP11B1 CYP11B2 HSD17B3 INSL3 MC2R NR5A1
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Drugs & Therapeutics for Adrenal Rest Tumor

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Search Clinical Trials , NIH Clinical Center for Adrenal Rest Tumor

Cochrane evidence based reviews: adrenal rest tumor

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Genetic Tests for Adrenal Rest Tumor

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Anatomical Context for Adrenal Rest Tumor

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MalaCards organs/tissues related to Adrenal Rest Tumor:

40
Ovary, Testis, Cortex, Adrenal Gland, Adrenal Cortex, Pituitary
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Publications for Adrenal Rest Tumor

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Articles related to Adrenal Rest Tumor:

(show top 50) (show all 64)
# Title Authors PMID Year
1
Total adrenal volume but not testicular adrenal rest tumor volume is associated with hormonal control in patients with 21-hydroxylase deficiency. 54 61
20190160 2010
2
Origin of an ovarian steroid cell tumor causing isosexual pseudoprecocious puberty demonstrated by the expression of adrenal steroidogenic enzymes and adrenocorticotropin receptor. 54 61
10720064 2000
3
[A case report: reversible male infertility due to congenital adrenal hyperplasia]. 61 54
8258942 1993
4
Incidental Finding of Bilateral Ovarian Adrenal Rest Tumor in a Patient With Congenital Adrenal Hyperplasia: A Case Report and Brief Review. 61
33433255 2021
5
A spontaneous pregnancy and live birth in a woman with primary infertility following the excision of an ovarian adrenal rest tumor: A rare case. 61
33105528 2020
6
Usefulness of Modified CEUS LI-RADS for the Diagnosis of Hepatocellular Carcinoma Using Sonazoid. 61
33076435 2020
7
A case of Williams syndrome with suspected coexisting ectopic aldosterone-producing tumor in the liver. 61
33434178 2020
8
[Clinical characteristics of testicular adrenal rest tumor and factors associated with its occurrence in 21-hydroxylase deficiency patients]. 61
32575926 2020
9
Testicular adrenal rest tumor in the background of congenital adrenal hyperplasia 61
32323966 2020
10
An unusual epididymal localization of Testicular Adrenal Rest Tumor in an adolescent with congenital adrenal hyperplasia. 61
31227992 2019
11
Characterization of the CYP11A1 Nonsynonymous Variant p.E314K in Children Presenting With Adrenal Insufficiency. 61
30299480 2019
12
Testicular adrenal rest tumor without congenital adrenal hyperplasia: A rare case. 61
30041282 2018
13
Editorial Comment to Testicular adrenal rest tumor without congenital adrenal hyperplasia: A rare case. 61
30276892 2018
14
Prevalence, clinical characteristics and long-term outcomes of classical 11 β-hydroxylase deficiency (11BOHD) in Turkish population and novel mutations in CYP11B1 gene. 61
29626607 2018
15
Testicular adrenal rest tumors. 61
30300134 2018
16
An Interesting Case of Hepatic Adrenocortical Carcinoma. 61
30333277 2018
17
Testicular adrenal rest tumor screening and fertility counseling among males with congenital adrenal hyperplasia. 61
29330018 2018
18
Gonadal function in adult male patients with congenital adrenal hyperplasia. 61
29339528 2018
19
Prevalence of Testicular Adrenal Rest Tumor and Factors Associated with Its Development in Congenital Adrenal Hyperplasia. 61
30149373 2018
20
Two cases of reversible male infertility due to congenital adrenal hyperplasia combined with testicular adrenal rest tumor. 61
29371828 2018
21
Trails on 18F-Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography Leading to Diagnosis of Testicular Adrenal Rest Tumor. 61
29430117 2018
22
Testicular Adrenal Rest Tumor (TART) in congenital adrenal hyperplasia. 61
28676275 2017
23
Testicular Adrenal Rest Tumors in Boys and Young Adults with Congenital Adrenal Hyperplasia. 61
27840017 2017
24
Testicular Adrenal Rest Tumor in Two Brothers with a Novel Mutation in the 3-Beta-Hydroxysteroid Dehydrogenase-2 Gene. 61
27476613 2017
25
Adrenal Rest Tumor of the Liver Preoperatively Diagnosed as Hepatocellular Carcinoma. 61
28706747 2017
26
Combined adrenal failure and testicular adrenal rest tumor in a patient with nicotinamide nucleotide transhydrogenase deficiency. 61
25879317 2015
27
Clinical manifestations of testicular adrenal rest tumor in males with congenital adrenal hyperplasia. 61
26512352 2015
28
Profiles of 21-Carbon Steroids in 21-hydroxylase Deficiency. 61
25850025 2015
29
Hepatic adrenal rest tumor: Diagnostic pitfall and proposed algorithms to prevent misdiagnosis as lipid-rich hepatocellular carcinoma. 61
25572108 2015
30
[Diagnostic benefits of adrenocortical scintigraphy in hepatic adrenal rest tumor]. 61
25283230 2014
31
Testicular adrenal rest tumor in an adolescent with congenital adrenal hyperplasia, resolved by therapy doses adjustment. 61
24826980 2014
32
Testicular adrenal rest tumor in 11-Beta-hydroxylase deficiency driven congenital adrenal hyperplasia. 61
24741421 2014
33
Bilateral ovary adrenal rest tumor in a congenital adrenal hyperplasia following adrenalectomy. 61
24449659 2014
34
Testicular adrenal rest tumor mimicking leydig cell tumor in a patient with congenital adrenal hyperplasia. 61
24834391 2014
35
Testicular adrenal rest "tumor" or Leydig cell tumor? A report of a challenging case with literature review. 61
23984262 2013
36
Malignant adrenal rest tumor of the retroperitoneum producing adrenocortical steroids. 61
21374072 2011
37
Testicular adrenal rest tumor in infertile man with congenital adrenal hyperplasia: case report and literature review. 61
22069134 2011
38
The prevalence of testicular adrenal rest tumors and associated factors in postpubertal patients with congenital adrenal hyperplasia caused by 21-hydroxylase deficiency. 61
21521928 2011
39
[Bilateral testicular tumor in a young man with congenital 11β-hydroxylase deficiency]. 61
20980225 2010
40
Hepatic adrenal rest tumor mimicking hepatocellular carcinoma. 61
20924220 2010
41
Testicular adrenal rest tumor in a patient with 11beta-hydroxylase deficient congenital adrenal hyperplasia. 61
20857846 2010
42
Ovarian adrenal rest tumor in a congenital adrenal hyperplasia patient with adrenocorticotropin hypersecretion following adrenalectomy. 61
20431278 2010
43
A case of adrenal rest tumor of the liver: Radiological imaging and immunohistochemical study of steroidogenic enzymes. 61
18564144 2008
44
Testicular tumors in patients with congenital adrenal hyperplasia due to 21-hydroxylase deficiency show functional features of adrenocortical tissue. 61
17595257 2007
45
[Adrenal rest tumor]. 61
16776258 2006
46
Testis sparing surgery for steroid unresponsive testicular tumors of the congenital adrenal hyperplasia. 61
16180005 2005
47
Fat-containing lesions of the liver: cross-sectional imaging findings with emphasis on MRI. 61
15788580 2005
48
Fat-containing lesions of the liver: radiologic-pathologic correlation. 61
15798052 2005
49
Nonfunctioning adrenal rest tumor of the liver: radiologic appearance. 61
11176302 2001
50
Adrenal rest tumor of the liver: a case report with immunohistochemical investigation of steroidogenesis. 61
10792789 2000
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Variations for Adrenal Rest Tumor

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Expression for Adrenal Rest Tumor

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Search GEO for disease gene expression data for Adrenal Rest Tumor.
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Pathways for Adrenal Rest Tumor

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Pathways related to Adrenal Rest Tumor according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Aldosterone synthesis and secretion 36
Show member pathways
 12.57 POMC NR5A1 MC2R HSD3B2 CYP21A2 CYP11B2
2
G alpha (s) signalling events 65
11.74 POMC MC2R INSL3
3
Corticotropin-releasing hormone signaling pathway 1
11.59 POMC HSD3B2 CYP21A2 CYP11B1
4
Androstenedione and testosterone biosynthesis and metabolism p.1 23
Show member pathways
 11.28 HSD3B2 HSD17B3 CYP11B1
5
Steroid hormone biosynthesis 36
Show member pathways
 11.18 HSD3B2 HSD17B3 CYP21A2 CYP11B2 CYP11B1
6
Metabolism of steroid hormones 65
Show member pathways
 11 POMC HSD3B2 HSD17B3 CYP21A2 CYP11B2 CYP11B1
7
superpathway of steroid hormone biosynthesis 1
Show member pathways
 10.78 HSD17B3 CYP21A2 CYP11B2 CYP11B1
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GO Terms for Adrenal Rest Tumor

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Biological processes related to Adrenal Rest Tumor according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 oxidation-reduction process GO:0055114 9.83 HSD3B2 HSD17B3 CYP21A2 CYP11B2 CYP11B1
2 cellular response to hormone stimulus GO:0032870 9.52 CYP11B2 CYP11B1
3 cellular response to peptide hormone stimulus GO:0071375 9.51 CYP11B2 CYP11B1
4 C21-steroid hormone biosynthetic process GO:0006700 9.49 CYP11B2 CYP11B1
5 cellular response to potassium ion GO:0035865 9.48 CYP11B2 CYP11B1
6 androgen biosynthetic process GO:0006702 9.46 HSD3B2 HSD17B3
7 sterol metabolic process GO:0016125 9.43 CYP21A2 CYP11B2 CYP11B1
8 cortisol biosynthetic process GO:0034651 9.4 CYP11B2 CYP11B1
9 cortisol metabolic process GO:0034650 9.37 CYP11B2 CYP11B1
10 steroid biosynthetic process GO:0006694 9.35 HSD3B2 HSD17B3 CYP21A2 CYP11B2 CYP11B1
11 mineralocorticoid biosynthetic process GO:0006705 9.33 HSD3B2 CYP21A2 CYP11B2
12 aldosterone biosynthetic process GO:0032342 9.32 CYP11B2 CYP11B1
13 glucocorticoid biosynthetic process GO:0006704 8.92 HSD3B2 CYP21A2 CYP11B2 CYP11B1

Molecular functions related to Adrenal Rest Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 heme binding GO:0020037 9.58 CYP21A2 CYP11B2 CYP11B1
2 oxidoreductase activity GO:0016491 9.55 HSD3B2 HSD17B3 CYP21A2 CYP11B2 CYP11B1
3 iron ion binding GO:0005506 9.54 CYP21A2 CYP11B2 CYP11B1
4 monooxygenase activity GO:0004497 9.5 CYP21A2 CYP11B2 CYP11B1
5 steroid hydroxylase activity GO:0008395 9.43 CYP21A2 CYP11B2
6 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen GO:0016705 9.43 CYP21A2 CYP11B2 CYP11B1
7 corticosterone 18-monooxygenase activity GO:0047783 8.96 CYP11B2 CYP11B1
8 steroid 11-beta-monooxygenase activity GO:0004507 8.62 CYP11B2 CYP11B1
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Sources for Adrenal Rest Tumor

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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