MCID: ADR001
MIFTS: 37

Adrenal Rest Tumor

Categories: Cancer diseases, Endocrine diseases

Aliases & Classifications for Adrenal Rest Tumor

MalaCards integrated aliases for Adrenal Rest Tumor:

Name: Adrenal Rest Tumor 12 55 44 15 73
Adrenal Rest Neoplasm 12

Classifications:



External Ids:

Disease Ontology 12 DOID:1786
MeSH 44 D000314
NCIt 50 C2860
SNOMED-CT 68 54292009
UMLS 73 C0001630

Summaries for Adrenal Rest Tumor

MalaCards based summary : Adrenal Rest Tumor, also known as adrenal rest neoplasm, is related to lipoid congenital adrenal hyperplasia and conn's syndrome. An important gene associated with Adrenal Rest Tumor is CYP21A2 (Cytochrome P450 Family 21 Subfamily A Member 2), and among its related pathways/superpathways are Metabolism and Cushing syndrome. Affiliated tissues include liver, ovary and lung, and related phenotypes are Decreased viability and Decreased viability

Related Diseases for Adrenal Rest Tumor

Diseases related to Adrenal Rest Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 132)
# Related Disease Score Top Affiliating Genes
1 lipoid congenital adrenal hyperplasia 30.6 CYP11B1 CYP11B2 CYP21A2 HSD3B1 HSD3B2 MC2R
2 conn's syndrome 29.3 CYP11B1 CYP11B2 CYP21A2 MC2R POMC PRL
3 3-beta-hydroxysteroid dehydrogenase deficiency 10.3 CYP21A2 HSD3B2
4 classic congenital adrenal hyperplasia due to 21-hydroxylase deficiency 10.3 CYP21A2 POMC
5 acute adrenal insufficiency 10.3 CYP21A2 POMC
6 cytochrome p450 oxidoreductase deficiency 10.3 CYP21A2 POMC
7 adrenal hyperplasia, congenital, due to 21-hydroxylase deficiency 10.3
8 glucocorticoid deficiency 1 10.3 MC2R POMC
9 ovarian serous adenofibroma 10.3 NCAM1 POMC
10 adrenal cortical hypofunction 10.2 CYP21A2 NR5A1 POMC
11 testicular leydig cell tumor 10.2 CYP21A2 HSD3B1 POMC
12 cortisone reductase deficiency 10.2 CYP21A2 NNT POMC
13 hypoadrenocorticism, familial 10.2 CYP21A2 MC2R POMC
14 aldosterone-producing adenoma 10.2 CYP11B2 CYP21A2
15 achalasia-addisonianism-alacrima syndrome 10.2 MC2R NNT POMC
16 familial glucocorticoid deficiency 10.2 MC2R NNT POMC
17 hypoaldosteronism 10.2 CYP11B2 POMC
18 lymphocytic hypophysitis 10.2 ENO2 POMC
19 multiple mucosal neuroma 10.2 ENO2 NCAM1
20 hyperaldosteronism, familial, type i 10.2 CYP11B1 CYP11B2 POMC
21 lung meningioma 10.2 ENO2 NCAM1
22 lung oat cell carcinoma 10.1 ENO2 POMC
23 bronchus cancer 10.1 ENO2 POMC
24 esophageal neuroendocrine tumor 10.1 NCAM1 SYP
25 ovarian large-cell neuroendocrine carcinoma 10.1 NCAM1 SYP
26 lung combined type small cell carcinoma 10.1 NCAM1 SYP
27 gangliocytoma 10.1 POMC SYP
28 acute thyroiditis 10.1 ENO2 POMC
29 middle cerebral artery infarction 10.1 ENO2 NCAM1
30 hepatocellular carcinoma 10.1
31 male infertility 10.1
32 leydig cell tumor 10.1
33 infertility 10.1
34 male reproductive organ benign neoplasm 10.1 NR5A1 POMC SYP
35 adrenal gland disease 10.1 CYP11B1 CYP11B2 MC2R POMC
36 hypoganglionosis 10.1 NCAM1 SYP
37 sex cord-gonadal stromal tumor 10.1 NR5A1 POMC SYP
38 spermatocele 10.1 NCAM1 NR5A1 SYP
39 pancreatic endocrine carcinoma 10.1 NCAM1 POMC SYP
40 adenohypophysitis 10.0 POMC PRL
41 carotid body cancer 10.0 ENO2 SYP
42 non-gestational ovarian choriocarcinoma 10.0 NCAM1 PRL
43 pancreatic serous cystadenoma 10.0 NCAM1 SYP
44 malignant sertoli cell tumor 10.0 ENO2 SYP
45 urinary bladder small cell neuroendocrine carcinoma 10.0 ENO2 SYP
46 conventional angiosarcoma 10.0 NCAM1 SYP
47 auditory system cancer 10.0 ENO2 SYP
48 sinonasal undifferentiated carcinoma 10.0 ENO2 SYP
49 pancreatic somatostatinoma 10.0 ENO2 SYP
50 small cell carcinoma of the bladder 10.0 ENO2 SYP

Graphical network of the top 20 diseases related to Adrenal Rest Tumor:



Diseases related to Adrenal Rest Tumor

Symptoms & Phenotypes for Adrenal Rest Tumor

GenomeRNAi Phenotypes related to Adrenal Rest Tumor according to GeneCards Suite gene sharing:

26 (show all 12)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00055-A-2 10.35 NCAM1 PLK1
2 Decreased viability GR00173-A 10.35 PLK1
3 Decreased viability GR00221-A-2 10.35 PLK1
4 Decreased viability GR00231-A 10.35 PLK1
5 Decreased viability GR00240-S-1 10.35 CYP11B1 PLK1
6 Decreased viability GR00301-A 10.35 PLK1
7 Decreased viability GR00342-S-1 10.35 PGK1
8 Decreased viability GR00342-S-3 10.35 PGK1
9 Decreased viability GR00381-A-1 10.35 NNT
10 Decreased viability GR00402-S-2 10.35 ARG1 CYP11B1 CYP11B2 CYP21A2 DUOX1 DUOX2
11 no effect GR00402-S-1 9.96 ARG1 CYP11B1 CYP11B2 CYP21A2 DUOX1 DUOX2
12 Reduced mammosphere formation GR00396-S 9.17 CYP11B1 CYP21A2 HSD3B2 MC2R NCAM1 PLK1

MGI Mouse Phenotypes related to Adrenal Rest Tumor:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 nervous system MP:0003631 9.36 ARG1 CYP11B2 DUOX2 ENO2 GNRH1 MC2R

Drugs & Therapeutics for Adrenal Rest Tumor

Search Clinical Trials , NIH Clinical Center for Adrenal Rest Tumor

Cochrane evidence based reviews: adrenal rest tumor

Genetic Tests for Adrenal Rest Tumor

Anatomical Context for Adrenal Rest Tumor

MalaCards organs/tissues related to Adrenal Rest Tumor:

41
Liver, Ovary, Lung, Bone, Pituitary, Pineal, Cortex

Publications for Adrenal Rest Tumor

Articles related to Adrenal Rest Tumor:

(show all 36)
# Title Authors Year
1
Trails on<sup>18</sup>F-Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography Leading to Diagnosis of Testicular Adrenal Rest Tumor. ( 29430117 )
2018
2
Two cases of reversible male infertility due to congenital adrenal hyperplasia combined with testicular adrenal rest tumor. ( 29371828 )
2018
3
Testicular adrenal rest tumor without congenital adrenal hyperplasia: A rare case. ( 30041282 )
2018
4
Prevalence of Testicular Adrenal Rest Tumor and Factors Associated with Its Development in Congenital Adrenal Hyperplasia. ( 30149373 )
2018
5
Editorial Comment to Testicular adrenal rest tumor without congenital adrenal hyperplasia: A rare case. ( 30276892 )
2018
6
Testicular Adrenal Rest Tumor (TART) in congenital adrenal hyperplasia. ( 28676275 )
2017
7
Adrenal Rest Tumor of the Liver Preoperatively Diagnosed as Hepatocellular Carcinoma. ( 28706747 )
2017
8
Testicular adrenal rest tumor screening and fertility counseling among males with congenital adrenal hyperplasia. ( 29330018 )
2017
9
Testicular Adrenal Rest Tumor In Brothers With Novel Mutation In 3-Beta Hydroxysteroid Dehydrogenase -2 Gene. ( 27476613 )
2016
10
Combined adrenal failure and testicular adrenal rest tumor in a patient with nicotinamide nucleotide transhydrogenase deficiency. ( 25879317 )
2015
11
Hepatic adrenal rest tumor: Diagnostic pitfall and proposed algorithms to prevent misdiagnosis as lipid-rich hepatocellular carcinoma. ( 25572108 )
2015
12
Clinical manifestations of testicular adrenal rest tumor in males with congenital adrenal hyperplasia. ( 26512352 )
2015
13
Bilateral ovary adrenal rest tumor in a congenital adrenal hyperplasia following adrenalectomy. ( 24449659 )
2014
14
Diagnostic benefits of adrenocortical scintigraphy in hepatic adrenal rest tumor. ( 25283230 )
2014
15
Testicular adrenal rest tumor in an adolescent with congenital adrenal hyperplasia, resolved by therapy doses adjustment. ( 24826980 )
2014
16
Testicular adrenal rest tumor in 11-Beta-hydroxylase deficiency driven congenital adrenal hyperplasia. ( 24741421 )
2014
17
Testicular adrenal rest tumor mimicking leydig cell tumor in a patient with congenital adrenal hyperplasia. ( 24834391 )
2014
18
Testicular adrenal rest tumor in infertile man with congenital adrenal hyperplasia: case report and literature review. ( 22069134 )
2011
19
Malignant adrenal rest tumor of the retroperitoneum producing adrenocortical steroids. ( 21374072 )
2011
20
Testicular adrenal rest tumor in a patient with 11beta-hydroxylase deficient congenital adrenal hyperplasia. ( 20857846 )
2010
21
Ovarian adrenal rest tumor in a congenital adrenal hyperplasia patient with adrenocorticotropin hypersecretion following adrenalectomy. ( 20431278 )
2010
22
Hepatic adrenal rest tumor mimicking hepatocellular carcinoma. ( 20924220 )
2010
23
Total adrenal volume but not testicular adrenal rest tumor volume is associated with hormonal control in patients with 21-hydroxylase deficiency. ( 20190160 )
2010
24
A case of adrenal rest tumor of the liver: Radiological imaging and immunohistochemical study of steroidogenic enzymes. ( 18564144 )
2008
25
Nonfunctioning adrenal rest tumor of the liver: radiologic appearance. ( 11176302 )
2001
26
Adrenal rest tumor of the liver: a case report with immunohistochemical investigation of steroidogenesis. ( 10792789 )
2000
27
Adrenal rest tumor of the broad ligament: case report with immunohistochemical study of steroidogenic enzymes. ( 9234389 )
1997
28
Adrenal rest tumor of the liver causing Cushing's syndrome: treatment with ketoconazole preceding an apparent surgical cure. ( 3964792 )
1985
29
Primary testicular abnormalities causing precocious puberty Leydig cell tumor, Leydig cell hyperplasia, and adrenal rest tumor. ( 6226233 )
1983
30
Endocrine studies in a patient with functioning adrenal rest tumor of the liver. ( 7234878 )
1981
31
Virilizing adrenal rest tumor of the ovary--a clinicomorphological study. ( 214297 )
1978
32
Fertility following treatment of adrenal rest tumor. ( 617541 )
1977
33
In vivo endocrine studies in adrenal rest tumor of ovary. ( 4277531 )
1974
34
Adrenal rest tumor of the liver. ( 14405693 )
1960
35
Ovarian adrenal rest tumor (masculinovoblastoma) simulating adrenal virilism; report of a case with hormone studies. ( 13469882 )
1957
36
Masculinovoblastoma or masculinizing adrenal rest tumor of ovary; report of a case. ( 14888529 )
1952

Variations for Adrenal Rest Tumor

Expression for Adrenal Rest Tumor

Search GEO for disease gene expression data for Adrenal Rest Tumor.

Pathways for Adrenal Rest Tumor

Pathways related to Adrenal Rest Tumor according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.85 ARG1 CYP11B1 CYP11B2 CYP21A2 DUOX1 DUOX2
2
Show member pathways
12.11 CYP11B1 CYP21A2 HSD3B1 HSD3B2 MC2R NR5A1
3
Show member pathways
11.95 CYP11B1 CYP11B2 CYP21A2 DUOX2 HSD3B1 HSD3B2
4 11.69 CYP11B1 CYP21A2 HSD3B1 HSD3B2 POMC
5
Show member pathways
11.47 CYP11B1 CYP11B2 CYP21A2 HSD3B1 HSD3B2
6
Show member pathways
11.38 CYP11B1 CYP11B2 CYP21A2 HSD3B1 HSD3B2 POMC
7
Show member pathways
11.34 CYP11B1 HSD3B1 HSD3B2
8
Show member pathways
10.87 CYP11B1 CYP11B2 CYP21A2

GO Terms for Adrenal Rest Tumor

Cellular components related to Adrenal Rest Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 mitochondrial inner membrane GO:0005743 9.55 CYP11B1 CYP11B2 HSD3B1 HSD3B2 NNT
2 smooth endoplasmic reticulum membrane GO:0030868 8.96 HSD3B1 HSD3B2
3 mitochondrial membrane GO:0031966 8.92 CYP11B1 CYP11B2 HSD3B1 HSD3B2

Biological processes related to Adrenal Rest Tumor according to GeneCards Suite gene sharing:

(show all 22)
# Name GO ID Score Top Affiliating Genes
1 oxidation-reduction process GO:0055114 9.86 CYP11B1 CYP11B2 CYP21A2 DUOX1 DUOX2 HSD3B1
2 steroid metabolic process GO:0008202 9.78 CYP11B1 CYP11B2 CYP21A2
3 female pregnancy GO:0007565 9.77 ARG1 GNRH1 PRL
4 cellular oxidant detoxification GO:0098869 9.72 DUOX1 DUOX2 NNT
5 cellular response to hormone stimulus GO:0032870 9.65 CYP11B1 CYP11B2 PRL
6 hormone metabolic process GO:0042445 9.6 DUOX2 NR5A1
7 male sex determination GO:0030238 9.58 GNRH1 NR5A1
8 C21-steroid hormone biosynthetic process GO:0006700 9.58 CYP11B1 CYP11B2
9 hormone biosynthetic process GO:0042446 9.57 DUOX1 DUOX2
10 thyroid hormone generation GO:0006590 9.56 DUOX1 DUOX2
11 steroid biosynthetic process GO:0006694 9.55 CYP11B1 CYP11B2 CYP21A2 HSD3B1 HSD3B2
12 androgen biosynthetic process GO:0006702 9.54 HSD3B1 HSD3B2
13 cellular response to potassium ion GO:0035865 9.52 CYP11B1 CYP11B2
14 ovulation cycle GO:0042698 9.51 GNRH1 PRL
15 sterol metabolic process GO:0016125 9.5 CYP11B1 CYP11B2 CYP21A2
16 hydrogen peroxide biosynthetic process GO:0050665 9.49 DUOX1 DUOX2
17 C21-steroid hormone metabolic process GO:0008207 9.46 HSD3B1 HSD3B2
18 aldosterone biosynthetic process GO:0032342 9.43 CYP11B1 CYP11B2
19 cortisol biosynthetic process GO:0034651 9.4 CYP11B1 CYP11B2
20 cuticle development GO:0042335 9.37 DUOX1 DUOX2
21 mineralocorticoid biosynthetic process GO:0006705 9.26 CYP11B2 CYP21A2 HSD3B1 HSD3B2
22 glucocorticoid biosynthetic process GO:0006704 9.02 CYP11B1 CYP11B2 CYP21A2 HSD3B1 HSD3B2

Molecular functions related to Adrenal Rest Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 9.65 GNRH1 POMC PRL
2 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen GO:0016705 9.63 CYP11B1 CYP11B2 CYP21A2
3 3-beta-hydroxy-delta5-steroid dehydrogenase activity GO:0003854 9.43 HSD3B1 HSD3B2
4 NAD(P)H oxidase activity GO:0016174 9.4 DUOX1 DUOX2
5 steroid delta-isomerase activity GO:0004769 9.37 HSD3B1 HSD3B2
6 heme binding GO:0020037 9.35 CYP11B1 CYP11B2 CYP21A2 DUOX1 DUOX2
7 cholesterol dehydrogenase activity GO:0102294 9.32 HSD3B1 HSD3B2
8 corticosterone 18-monooxygenase activity GO:0047783 9.26 CYP11B1 CYP11B2
9 oxidoreductase activity GO:0016491 9.23 CYP11B1 CYP11B2 CYP21A2 DUOX1 DUOX2 HSD3B1
10 steroid 11-beta-monooxygenase activity GO:0004507 9.16 CYP11B1 CYP11B2

Sources for Adrenal Rest Tumor

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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