Adrenal Rest Tumor disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Adrenal Rest Tumor

MalaCards integrated aliases for Adrenal Rest Tumor:

Name: Adrenal Rest Tumor ¹¹ ⁵³ ⁴³ ¹⁴ ¹⁶ ⁷¹

Adrenal Rest Neoplasm ¹¹

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Endocrine diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹¹ DOID:1786

MeSH ⁴³ D000314

NCIt ⁴⁹ C2860

SNOMED-CT ⁶⁸ 54292009

EFO ¹⁶ EFO_1000798

UMLS ⁷¹ C0001630

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Summaries for Adrenal Rest Tumor

MalaCards based summary: Adrenal Rest Tumor, also known as adrenal rest neoplasm, is related to luteoma and leydig cell tumor. An important gene associated with Adrenal Rest Tumor is CYP21A2 (Cytochrome P450 Family 21 Subfamily A Member 2), and among its related pathways/superpathways are Metabolism and Disease. Affiliated tissues include liver, ovary and hypothalamus, and related phenotypes are Reduced mammosphere formation and growth/size/body region

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Related Diseases for Adrenal Rest Tumor

Diseases related to Adrenal Rest Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 88)

#	Related Disease	Score	Top Affiliating Genes
1	luteoma	30.1	EPPIN CYP21A2
2	leydig cell tumor	30.1	INSL3 CYP21A2 CYP11A1
3	acute adrenal insufficiency	29.9	POMC CYP21A2 CYP11A1
4	infertility	29.7	INSL3 EPPIN CYP21A2 CYP11A1
5	adenoma	29.3	POMC MC2R CYP11B2 CYP11B1
6	conn's syndrome	28.8	POMC MC2R HSD3B2 CYP21A2 CYP11B2 CYP11B1
7	lipoid congenital adrenal hyperplasia	28.7	POMC MC2R INSL3 HSD3B2 HSD17B3 CYP21A2
8	familial glucocorticoid deficiency	28.5	POMC MC2R HSD3B2 CYP21A2 CYP11B2 CYP11B1
9	adrenal adenoma	28.4	POMC MC2R EPPIN CYP21A2 CYP11B2 CYP11B1
10	adrenal hyperplasia, congenital, due to 21-hydroxylase deficiency	10.4
11	posttransplant acute limbic encephalitis	10.3
12	azoospermia	10.2
13	testicular cancer	10.2
14	precocious puberty	10.2
15	hypoglycemic coma	10.1	POMC EPPIN
16	precocious puberty, male-limited	10.1	POMC CYP21A2
17	waterhouse-friderichsen syndrome	10.1	POMC MC2R
18	pituitary-dependent cushing's disease	10.1	POMC MC2R
19	corticosteroid-binding globulin deficiency	10.1	POMC MC2R
20	leiomyoma, uterine	10.1
21	down syndrome	10.1
22	adrenal hyperplasia, congenital, due to steroid 11-beta-hydroxylase deficiency	10.1
23	premature ovarian failure 7	10.1
24	leiomyoma	10.1
25	germinoma	10.1	POMC CYP21A2
26	glucocorticoid deficiency 1	10.1	POMC MC2R
27	mixed gonadal dysgenesis	10.1	HSD17B3 CYP21A2
28	cytochrome p450 oxidoreductase deficiency	10.1	HSD3B2 CYP21A2 CYP11B1
29	sebaceous gland disease	10.1	POMC CYP21A2
30	autoimmune polyendocrine syndrome, type i, with or without reversible metaphyseal dysplasia	10.1	CYP21A2 CYP11A1
31	aromatase excess syndrome	10.0	POMC EPPIN
32	intrauterine growth retardation, metaphyseal dysplasia, adrenal hypoplasia congenita, and genital anomalies	10.0	MC2R CYP11A1
33	adrenal hyperplasia, congenital, due to 3-beta-hydroxysteroid dehydrogenase 2 deficiency	10.0
34	glucocorticoid deficiency 4 with or without mineralocorticoid deficiency	10.0
35	rapidly involuting congenital hemangioma	10.0
36	male infertility	10.0
37	amenorrhea	10.0
38	nelson syndrome	10.0
39	adrenogenital syndrome	10.0
40	primary adrenal insufficiency	10.0
41	testicular torsion	10.0	INSL3 EPPIN
42	antley-bixler syndrome	9.9	POMC CYP21A2 CYP11A1
43	hypoaldosteronism	9.9	POMC CYP11B2
44	mccune-albright syndrome	9.9	POMC MC2R
45	complete androgen insensitivity syndrome	9.9	INSL3 HSD17B3
46	achalasia-addisonianism-alacrima syndrome	9.9	POMC MC2R CYP11A1
47	17-beta hydroxysteroid dehydrogenase iii deficiency	9.9	POMC HSD17B3 CYP11A1
48	persistent mullerian duct syndrome	9.8	INSL3 HSD17B3 CYP21A2
49	polycystic ovary syndrome	9.8	POMC HSD3B2 CYP21A2 CYP11A1
50	inguinal hernia	9.8	POMC INSL3 HSD17B3

Graphical network of the top 20 diseases related to Adrenal Rest Tumor:

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Symptoms & Phenotypes for Adrenal Rest Tumor

GenomeRNAi Phenotypes related to Adrenal Rest Tumor according to GeneCards Suite gene sharing:

²⁵

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Reduced mammosphere formation	GR00396-S	9.02	CYP11B1 CYP21A2 HSD3B2 MC2R POMC

MGI Mouse Phenotypes related to Adrenal Rest Tumor:

⁴⁵

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	growth/size/body region	MP:0005378	9.97	CYP11A1 CYP11B1 CYP11B2 CYP21A2 EPPIN HSD17B3
2	endocrine/exocrine gland	MP:0005379	9.86	CYP11A1 CYP11B1 CYP11B2 EPPIN HSD17B3 INSL3
3	adipose tissue	MP:0005375	9.77	CYP11B1 CYP11B2 HSD17B3 MC2R POMC
4	immune system	MP:0005387	9.76	CYP11A1 CYP11B1 CYP11B2 CYP21A2 EPPIN HSD17B3
5	reproductive system	MP:0005389	9.5	CYP11A1 CYP11B1 CYP11B2 EPPIN HSD17B3 INSL3
6	hematopoietic system	MP:0005397	9.23	CYP11A1 CYP11B1 CYP11B2 CYP21A2 EPPIN HSD17B3

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Drugs & Therapeutics for Adrenal Rest Tumor

Search Clinical Trials, NIH Clinical Center for Adrenal Rest Tumor

Cochrane evidence based reviews: adrenal rest tumor

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Genetic Tests for Adrenal Rest Tumor

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Anatomical Context for Adrenal Rest Tumor

Organs/tissues related to Adrenal Rest Tumor:

MalaCards : Liver, Ovary, Hypothalamus, Testis, Pituitary

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Publications for Adrenal Rest Tumor

Articles related to Adrenal Rest Tumor:

(show top 50) (show all 73)

#	Title	Authors	PMID	Year
1	Total adrenal volume but not testicular adrenal rest tumor volume is associated with hormonal control in patients with 21-hydroxylase deficiency. ⁵³ ⁶²	Reisch N...Beuschlein F	20190160	2010
2	Origin of an ovarian steroid cell tumor causing isosexual pseudoprecocious puberty demonstrated by the expression of adrenal steroidogenic enzymes and adrenocorticotropin receptor. ⁵³ ⁶²	Lin CJ...Mendonca BB	10720064	2000
3	[A case report: reversible male infertility due to congenital adrenal hyperplasia]. ⁵³ ⁶²	Iwamoto T...Osada T	8258942	1993
4	Genotype of congenital adrenal hyperplasia patients with testicular adrenal rest tumor. ⁶²	Aycan Z...Cetinkaya S	36343887	2022
5	Unilateral orchiectomy of a testicular adrenal rest tumor: Case report and review of management options. ⁶²	Able C...Farhan B	36248778	2022
6	Congenital adrenal hyperplasia, disorders of sex development, and infertility in patients with POR gene pathogenic variants: a systematic review of the literature. ⁶²	Gusmano C...Calogero AE	35842891	2022
7	Current status of transition medicine for 21-hydroxylase deficiency in Japan: from the perspective of pediatric endocrinologists. ⁶²	Takasawa K...Ida S	34373418	2022
8	Genotype, Mortality, Morbidity, and Outcomes of 3β-Hydroxysteroid Dehydrogenase Deficiency in Algeria. ⁶²	Ladjouze A...Roucher-Boulez F	35757411	2022
9	Ovarian adrenal rest tumor in congenital adrenal hyperplasia: Is medical treatment the first line option? ⁶²	Koren R...Vaknin Z	34762785	2021
10	11-oxygenated androgens and their relation to hypothalamus-pituitary-gonadal-axis disturbances in adults with congenital adrenal hyperplasia. ⁶²	Auer MK...Reisch N	34058329	2021
11	Incidental Finding of Bilateral Ovarian Adrenal Rest Tumor in a Patient With Congenital Adrenal Hyperplasia: A Case Report and Brief Review. ⁶²	Bouzidi L...Boudawara T	33433255	2021
12	Atypical Presentation of Testicular Adrenal Rest Tumor (TART) Leading to Bilateral Partial Orchiectomy in a 31-Year-Old Adult Revealing Primary Adrenal Insufficiency with CYP11A1 Deficiency. ⁶²	Garcia C...Bordier L	34976419	2021
13	Morphologic and Molecular Characterization of Adrenals and Adrenal Rest Affected by Congenital Adrenal Hyperplasia. ⁶²	Kolli V...Merke DP	34616364	2021
14	A spontaneous pregnancy and live birth in a woman with primary infertility following the excision of an ovarian adrenal rest tumor: A rare case. ⁶²	Uyanikoglu H...Kahraman S	33105528	2020
15	Usefulness of Modified CEUS LI-RADS for the Diagnosis of Hepatocellular Carcinoma Using Sonazoid. ⁶²	Sugimoto K...Itoi T	33076435	2020
16	A case of Williams syndrome with suspected coexisting ectopic aldosterone-producing tumor in the liver. ⁶²	Baba S...Wada N	33434178	2020
17	[Clinical characteristics of testicular adrenal rest tumor and factors associated with its occurrence in 21-hydroxylase deficiency patients]. ⁶²	Gao YJ...Nie M	32575926	2020
18	Testicular adrenal rest tumor in the background of congenital adrenal hyperplasia ⁶²	Brzozka A...Fejes Z	32323966	2020
19	An unusual epididymal localization of Testicular Adrenal Rest Tumor in an adolescent with congenital adrenal hyperplasia. ⁶²	Corica D...Ascenti G	31227992	2019
20	Characterization of the CYP11A1 Nonsynonymous Variant p.E314K in Children Presenting With Adrenal Insufficiency. ⁶²	Kolli V...Merke DP	30299480	2019
21	Testicular adrenal rest tumor without congenital adrenal hyperplasia: A rare case. ⁶²	Osaka A...Okada H	30041282	2018
22	Editorial Comment to Testicular adrenal rest tumor without congenital adrenal hyperplasia: A rare case. ⁶²	Armas Alvarez AL	30276892	2018
23	Prevalence, clinical characteristics and long-term outcomes of classical 11 β-hydroxylase deficiency (11BOHD) in Turkish population and novel mutations in CYP11B1 gene. ⁶²	Bas F...Darendeliler F	29626607	2018
24	Testicular adrenal rest tumors. ⁶²	Armas-Alvarez AL...Virseda-Rodriguez JA	30300134	2018
25	An Interesting Case of Hepatic Adrenocortical Carcinoma. ⁶²	Permana H...Soetedjo NN	30333277	2018
26	Testicular adrenal rest tumor screening and fertility counseling among males with congenital adrenal hyperplasia. ⁶²	Chaudhari M...Nahata L	29330018	2018
27	Gonadal function in adult male patients with congenital adrenal hyperplasia. ⁶²	Engels M...dsd-LIFE group	29339528	2018
28	Two cases of reversible male infertility due to congenital adrenal hyperplasia combined with testicular adrenal rest tumor. ⁶²	Tanaka M...Fujisawa M	29371828	2018
29	Prevalence of Testicular Adrenal Rest Tumor and Factors Associated with Its Development in Congenital Adrenal Hyperplasia. ⁶²	Mendes-Dos-Santos CT...Lemos-Marini SHV	30149373	2018
30	Trails on 18F-Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography Leading to Diagnosis of Testicular Adrenal Rest Tumor. ⁶²	Kashyap R	29430117	2018
31	Testicular Adrenal Rest Tumor (TART) in congenital adrenal hyperplasia. ⁶²	Ozisik H...Saygili F	28676275	2017
32	Testicular Adrenal Rest Tumor in Two Brothers with a Novel Mutation in the 3-Beta-Hydroxysteroid Dehydrogenase-2 Gene. ⁶²	Guven A...Polat S	27476613	2017
33	Testicular Adrenal Rest Tumors in Boys and Young Adults with Congenital Adrenal Hyperplasia. ⁶²	Kim MS...Kokorowski PJ	27840017	2017
34	Adrenal Rest Tumor of the Liver Preoperatively Diagnosed as Hepatocellular Carcinoma. ⁶²	Enjoji M...Maeda M	28706747	2017
35	Clinical manifestations of testicular adrenal rest tumor in males with congenital adrenal hyperplasia. ⁶²	Yu MK...Kim HS	26512352	2015
36	Combined adrenal failure and testicular adrenal rest tumor in a patient with nicotinamide nucleotide transhydrogenase deficiency. ⁶²	Hershkovitz E...Parvari R	25879317	2015
37	Profiles of 21-Carbon Steroids in 21-hydroxylase Deficiency. ⁶²	Turcu AF...Auchus RJ	25850025	2015
38	Hepatic adrenal rest tumor: Diagnostic pitfall and proposed algorithms to prevent misdiagnosis as lipid-rich hepatocellular carcinoma. ⁶²	Sugiyama T...Nakamura N	25572108	2015
39	[Diagnostic benefits of adrenocortical scintigraphy in hepatic adrenal rest tumor]. ⁶²	Ishida K...Kaneko S	25283230	2014
40	Testicular adrenal rest tumor in an adolescent with congenital adrenal hyperplasia, resolved by therapy doses adjustment. ⁶²	Corica D...De Luca F	24826980	2014
41	Testicular adrenal rest tumor in 11-Beta-hydroxylase deficiency driven congenital adrenal hyperplasia. ⁶²	Kaynar M...Sumer A	24741421	2014
42	Bilateral ovary adrenal rest tumor in a congenital adrenal hyperplasia following adrenalectomy. ⁶²	Zaarour MG...Halaby GH	24449659	2014
43	Testicular adrenal rest tumor mimicking leydig cell tumor in a patient with congenital adrenal hyperplasia. ⁶²	Karakus E...Tiryaki T	24834391	2014
44	Testicular adrenal rest "tumor" or Leydig cell tumor? A report of a challenging case with literature review. ⁶²	Ali HH...Arabi H	23984262	2013
45	Malignant adrenal rest tumor of the retroperitoneum producing adrenocortical steroids. ⁶²	Akishima-Fukasawa Y...Yoshino G	21374072	2011
46	Testicular adrenal rest tumor in infertile man with congenital adrenal hyperplasia: case report and literature review. ⁶²	Marchini GS...Srougi M	22069134	2011
47	The prevalence of testicular adrenal rest tumors and associated factors in postpubertal patients with congenital adrenal hyperplasia caused by 21-hydroxylase deficiency. ⁶²	Kang MJ...Yang SW	21521928	2011
48	[Bilateral testicular tumor in a young man with congenital 11β-hydroxylase deficiency]. ⁶²	Vajda Z...Racz K	20980225	2010
49	Hepatic adrenal rest tumor mimicking hepatocellular carcinoma. ⁶²	Shin YM	20924220	2010
50	Testicular adrenal rest tumor in a patient with 11beta-hydroxylase deficient congenital adrenal hyperplasia. ⁶²	Bayhan GI...Aycan Z	20857846	2010

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Genes for Adrenal Rest Tumor

Genes related to Adrenal Rest Tumor (0 elite genes):

(show all 11)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubMed IDs
1	CYP21A2	Cytochrome P450 Family 21 Subfamily A Member 2	Protein Coding	18.62	DISEASES inferred ¹⁴ Novoseek inferred ⁵³	20190160 8258942 10720064
2	HSD3B2	Hydroxy-Delta-5-Steroid Dehydrogenase, 3 Beta- And Steroid Delta-Isomerase 2	Protein Coding	14.09	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
3	POMC	Proopiomelanocortin	Protein Coding	7.58	DISEASES inferred ¹⁴
4	CYP11B1	Cytochrome P450 Family 11 Subfamily B Member 1	Protein Coding	7.24	DISEASES inferred ¹⁴
5	EPPIN	Epididymal Peptidase Inhibitor	Protein Coding	7.2	DISEASES inferred ¹⁴ ¹⁴
6	MC2R	Melanocortin 2 Receptor	Protein Coding	6.74	DISEASES inferred ¹⁴
7	HSD17B3	Hydroxysteroid 17-Beta Dehydrogenase 3	Protein Coding	6.66	DISEASES inferred ¹⁴
8	MIA2	MIA SH3 Domain ER Export Factor 2	Protein Coding	6.6	DISEASES inferred ¹⁴ ¹⁴
9	INSL3	Insulin Like 3	Protein Coding	6.33	DISEASES inferred ¹⁴
10	CYP11B2	Cytochrome P450 Family 11 Subfamily B Member 2	Protein Coding	6.24	DISEASES inferred ¹⁴
11	CYP11A1	Cytochrome P450 Family 11 Subfamily A Member 1	Protein Coding	5.93	DISEASES inferred ¹⁴

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Variations for Adrenal Rest Tumor

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Expression for Adrenal Rest Tumor

Search GEO for disease gene expression data for Adrenal Rest Tumor.

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Pathways for Adrenal Rest Tumor

Pathways related to Adrenal Rest Tumor according to GeneCards Suite gene sharing:

(show all 13)

#	Super pathways	Score	Top Affiliating Genes
1	Metabolism ⁶⁶ Show member pathways Metabolism of lipids ⁶⁶	13.5	POMC HSD3B2 HSD17B3 CYP21A2 CYP11B2 CYP11B1
2	Disease ⁶⁶ Show member pathways Infectious disease ⁶⁶	13.43	POMC MC2R CYP21A2 CYP11B2 CYP11B1 CYP11A1
3	Metapathway biotransformation Phase I and II ⁷⁴ Show member pathways Acetaminophen metabolism ²² Aflatoxin B1 metabolism ⁷⁴ Artemisinin and Derivatives Pathway, Pharmacokinetics ⁶⁰ Arylamine metabolism ⁷⁴ Benzo(a)pyrene metabolism ⁷⁴ Benzo[a]pyrene metabolism ²² Benzodiazepine Pathway, Pharmacokinetics ⁶⁰ Biological oxidations ⁶⁶ Cannabidiol Pathway, Pharmacokinetics ⁶⁰ Doxepin Pathway, Pharmacokinetics ⁶⁰ Estradiol metabolism ²² Flurbiprofen Pathway, Pharmacokinetics ⁶⁰ Haloperidol Pathway, Pharmacokinetics ⁶⁰ Methylation ⁶⁶ Naproxen Pathway, Pharmacokinetics ⁶⁰ Phase II - Conjugation of compounds ⁶⁶ Phenprocoumon Pathway, Pharmacokinetics ⁶⁰ Sorafenib Pharmacokinetics ⁶⁰ Tamoxifen Pathway, Pharmacokinetics ⁶⁰ Voriconazole Pathway, Pharmacokinetics ⁶⁰	12.71	POMC CYP21A2 CYP11B2 CYP11B1 CYP11A1
4	Diseases of glycosylation ⁶⁶ Show member pathways Defective ALG1 causes CDG-1k ⁶⁶ Defective ALG11 causes CDG-1p ⁶⁶ Defective ALG12 causes CDG-1g ⁶⁶ Defective ALG14 causes ALG14-CMS ⁶⁶ Defective ALG2 causes CDG-1i ⁶⁶ Defective ALG3 causes CDG-1d ⁶⁶ Defective ALG6 causes CDG-1c ⁶⁶ Defective ALG8 causes CDG-1h ⁶⁶ Defective ALG9 causes CDG-1l ⁶⁶ Defective DPAGT1 causes CDG-1j, CMSTA2 ⁶⁶ Defective GNE causes sialuria, NK and IBM2 ⁶⁶ Defective MPDU1 causes CDG-1f ⁶⁶ Defective NEU1 causes sialidosis ⁶⁶ Defective RFT1 causes CDG-1n ⁶⁶ Diseases associated with glycosylation precursor biosynthesis ⁶⁶ Diseases associated with N-glycosylation of proteins ⁶⁶ Diseases of metabolism ⁶⁶ MPS IV - Morquio syndrome B ⁶⁶	12.49	CYP11A1 CYP11B1 CYP11B2 CYP21A2 MC2R POMC
5	Oxidation by cytochrome P450 ⁷⁴ Show member pathways Amine Oxidase reactions ⁶⁶ Aryl hydrocarbon receptor signalling ⁶⁶ Atomoxetine Pathway, Pharmacokinetics ⁶⁰ Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB ⁶⁶ Celecoxib Pathway, Pharmacokinetics ⁶⁰ Cyclophosphamide Pathway, Pharmacokinetics ⁶⁰ CYP2E1 reactions ⁶⁶ Cytochrome P450 - arranged by substrate type ⁶⁶ Defective CYP24A1 causes HCAI ⁶⁶ Defective CYP26B1 causes RHFCA ⁶⁶ Defective CYP26C1 causes FFDD4 ⁶⁶ Defective CYP27A1 causes CTX ⁶⁶ Defective CYP27B1 causes VDDR1A ⁶⁶ Defective CYP27B1 causes VDDR1B ⁶⁶ Defective CYP4F22 causes ARCI5 ⁶⁶ Defective MAOA causes BRUNS ⁶⁶ Eicosanoids ⁶⁶ Endogenous sterols ⁶⁶ Ethanol oxidation ⁶⁶ Fatty acid omega-oxidation ⁷⁴ Fatty acids ⁶⁶ Fluvoxamine Pathway, Pharmacokinetics ⁶⁰ Lidocaine Pathway, Pharmacokinetics ⁶⁰ Miscellaneous substrates ⁶⁶ Phase I - Functionalization of compounds ⁶⁶ Prasugrel Pathway, Pharmacokinetics ⁶⁰ Sterols are 12-hydroxylated by CYP8B1 ⁶⁶ Vitamin D2 (ergocalciferol) metabolism ²² Vitamins ⁶⁶ Xenobiotics ⁶⁶	12.47	POMC CYP21A2 CYP11B2 CYP11B1 CYP11A1
6	Metabolism of steroids ⁶⁶ Show member pathways Activation of gene expression by SREBF (SREBP) ⁶⁶ allopregnanolone biosynthesis ⁶¹ androgen biosynthesis ⁶¹ Cholesterol synthesis disorders ⁷⁴ Defective CYP17A1 causes AH5 ⁶⁶ Regulation of cholesterol biosynthesis by SREBP (SREBF) ⁶⁶ Sterol regulatory element-binding proteins (SREBP) signaling ⁷⁴ Vitamin D (calciferol) metabolism ⁶⁶	12.06	POMC HSD3B2 HSD17B3 CYP21A2 CYP11B2 CYP11B1
7	G alpha (s) signalling events ⁶⁶ Show member pathways Defective ACTH causes obesity and POMCD ⁶⁶	11.89	POMC MC2R INSL3
8	Corticotropin-releasing hormone signaling pathway ⁷⁴	11.51	POMC HSD3B2 CYP21A2 CYP11B1 CYP11A1
9	Androstenedione and testosterone biosynthesis and metabolism p.1 ²² Show member pathways Estrogen biosynthesis ²² Estrone metabolism ²² Steroid biosynthesis ⁷⁴	11.37	HSD3B2 HSD17B3 CYP11B1
10	Metabolism of steroid hormones ⁶⁶ Show member pathways Androgen biosynthesis ⁶⁶ Defective CYP11A1 causes AICSR ⁶⁶ Defective CYP11B1 causes AH4 ⁶⁶ Defective CYP21A2 causes AH3 ⁶⁶ Electron transport from NADPH to Ferredoxin ⁶⁶ Estrogen biosynthesis ⁶⁶ Glucocorticoid and Mineralcorticoid Metabolism ⁷⁴ Glucocorticoid biosynthesis ⁶⁶ Mineralocorticoid biosynthesis ⁶⁶ Pregnenolone biosynthesis ⁶⁶	11.15	POMC HSD3B2 HSD17B3 CYP21A2 CYP11B2 CYP11B1
11	Metabolic disorders of biological oxidation enzymes ⁶⁶	11.09	CYP21A2 CYP11B2 CYP11B1 CYP11A1
12	Alternative pathway of fetal androgen synthesis ⁷⁴	10.62	HSD3B2 HSD17B3 CYP11A1
13	Classical pathway of steroidogenesis with glucocorticoid and mineralocorticoid metabolism ⁷⁴ Show member pathways Defective CYP11B2 causes CMO-1 deficiency ⁶⁶ progesterone biosynthesis ⁶¹	10.4	HSD3B2 CYP11B2 CYP11A1

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GO Terms for Adrenal Rest Tumor

Biological processes related to Adrenal Rest Tumor according to GeneCards Suite gene sharing:

(show all 17)

#	Name	GO ID	Score	Top Affiliating Genes
1	cholesterol metabolic process	GO:0008203	10.01	CYP11B2 CYP11B1 CYP11A1
2	lipid metabolic process	GO:0006629	9.91	HSD3B2 HSD17B3 CYP21A2 CYP11B2 CYP11B1 CYP11A1
3	cellular response to hormone stimulus	GO:0032870	9.87	CYP11B2 CYP11B1
4	positive regulation of cAMP-mediated signaling	GO:0043950	9.86	POMC INSL3
5	cellular response to potassium ion	GO:0035865	9.85	CYP11B2 CYP11B1
6	cellular response to peptide hormone stimulus	GO:0071375	9.85	CYP11B2 CYP11B1 CYP11A1
7	androgen biosynthetic process	GO:0006702	9.83	HSD3B2 HSD17B3
8	cortisol biosynthetic process	GO:0034651	9.8	CYP11B2 CYP11B1
9	steroid metabolic process	GO:0008202	9.8	CYP11A1 CYP11B1 CYP11B2 CYP21A2
10	C21-steroid hormone biosynthetic process	GO:0006700	9.8	CYP11B2 CYP11B1 CYP11A1
11	aldosterone biosynthetic process	GO:0032342	9.78	CYP11B2 CYP11B1
12	mineralocorticoid biosynthetic process	GO:0006705	9.76	CYP21A2 CYP11B2
13	sterol metabolic process	GO:0016125	9.76	CYP11A1 CYP11B1 CYP11B2 CYP21A2
14	cortisol metabolic process	GO:0034650	9.73	CYP11B2 CYP11B1 CYP11A1
15	C21-steroid hormone metabolic process	GO:0008207	9.69	CYP11A1 HSD3B2
16	glucocorticoid biosynthetic process	GO:0006704	9.56	CYP21A2 CYP11B2 CYP11B1 CYP11A1
17	steroid biosynthetic process	GO:0006694	9.28	HSD3B2 HSD17B3 CYP21A2 CYP11B2 CYP11B1 CYP11A1

Molecular functions related to Adrenal Rest Tumor according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	heme binding	GO:0020037	10.01	CYP21A2 CYP11B2 CYP11B1 CYP11A1
2	iron ion binding	GO:0005506	9.97	CYP21A2 CYP11B2 CYP11B1 CYP11A1
3	steroid hydroxylase activity	GO:0008395	9.73	CYP21A2 CYP11B2
4	steroid 11-beta-monooxygenase activity	GO:0004507	9.62	CYP11B1 CYP11B2
5	corticosterone 18-monooxygenase activity	GO:0047783	9.56	CYP11B1 CYP11B2
6	oxidoreductase activity	GO:0016491	9.5	HSD3B2 HSD17B3 CYP21A2 CYP11B2 CYP11B1 CYP11A1
7	monooxygenase activity	GO:0004497	9.46	CYP21A2 CYP11B2 CYP11B1 CYP11A1
8	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	GO:0016705	8.92	CYP21A2 CYP11B2 CYP11B1 CYP11A1

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Sources for Adrenal Rest Tumor

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⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 08-Dec-2022)

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⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ WikiPathways

⁷⁵ Wikipedia

MCID: ADR001 MIFTS: 33	Adrenal Rest Tumor Categories: Cancer diseases, Endocrine diseases	Data Licensing For inquiries, contact: [email protected]
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