Adult Acute Lymphocytic Leukemia disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: ADL052 MIFTS: 44	Adult Acute Lymphocytic Leukemia Categories: Blood diseases, Bone diseases, Cancer diseases, Immune diseases, Rare diseases
Genes Tissues Related diseases Publications Pathways Drugs Expand all tables

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Aliases & Classifications for Adult Acute Lymphocytic Leukemia

MalaCards integrated aliases for Adult Acute Lymphocytic Leukemia:

Name: Adult Acute Lymphocytic Leukemia ³⁸ ¹² ⁵⁵ ¹⁵ ⁷³

Adult Acute Lymphoid Leukemia ¹²

Classifications:

MalaCards categories:
Global: Cancer diseases Rare diseases
Anatomical: Blood diseases Immune diseases Bone diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:5604

NCIt ⁵⁰ C4967

UMLS ⁷³ C0751606

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Summaries for Adult Acute Lymphocytic Leukemia

MalaCards based summary : Adult Acute Lymphocytic Leukemia, also known as adult acute lymphoid leukemia, is related to t-cell adult acute lymphocytic leukemia and acute lymphocytic leukemia. An important gene associated with Adult Acute Lymphocytic Leukemia is SHMT1 (Serine Hydroxymethyltransferase 1), and among its related pathways/superpathways are Selenium Micronutrient Network and Carbon metabolism. The drugs Marqibo and Vincristine have been mentioned in the context of this disorder. Affiliated tissues include Blood and Blood, and related phenotypes are homeostasis/metabolism and neoplasm

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Related Diseases for Adult Acute Lymphocytic Leukemia

Diseases in the Lymphocytic Leukemia family:

Leukemia, Chronic Lymphocytic 2	Leukemia, Chronic Lymphocytic
Leukemia, Chronic Lymphocytic 1	Leukemia, Chronic Lymphocytic 3
Leukemia, Chronic Lymphocytic 4	Leukemia, Chronic Lymphocytic 5
Acute Lymphocytic Leukemia	Adult Acute Lymphocytic Leukemia

Diseases related to Adult Acute Lymphocytic Leukemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 35)

#	Related Disease	Score	Top Affiliating Genes
1	t-cell adult acute lymphocytic leukemia	33.5	CD2 INPP5D
2	acute lymphocytic leukemia	30.8	CDKN2B CSF3 MTHFR TYMS
3	b-cell adult acute lymphocytic leukemia	12.4
4	lymphocytic leukemia	10.7
5	leukemia	10.7
6	lymphoid leukemia	10.2
7	bile reflux	10.2	CDX1 CDX2
8	hemifacial spasm	10.1	MTHFR TYMS
9	gastric cardia carcinoma	10.1	MTHFR TYMS
10	homocystinuria due to deficiency of n -methylenetetrahydrofolate reductase activity	10.1	MTHFR MTR
11	cardia cancer	10.1	MTHFR TYMS
12	macroglossia	10.1	CDKN1C CSF3
13	vitamin metabolic disorder	10.1	MTHFR MTR
14	ewing's family of tumors	10.1	CDKN2B CSF3
15	neural tube defects, folate-sensitive	10.0	MTHFR MTR
16	placental choriocarcinoma	10.0	ABCG2 MTR
17	vitamin b12 deficiency	10.0	MTHFR MTR
18	core binding factor acute myeloid leukemia	10.0	ABCG2 CSF3
19	transcobalamin ii deficiency	10.0	MTHFR MTR
20	hematopoietic stem cell transplantation	10.0
21	intestinal benign neoplasm	10.0	CDX2 MTHFR
22	mucositis	9.9	CSF3 MTHFR TYMS
23	neural tube defects	9.9	MTHFR MTR SHMT1 TYMS
24	amino acid metabolic disorder	9.9	MTHFR MTR
25	adult lymphoma	9.8	CD2 CSF3
26	breast cancer	9.8
27	neurofibromatosis, type i	9.8
28	lymphoma, hodgkin, classic	9.8
29	lymphoma, non-hodgkin, familial	9.8
30	severe combined immunodeficiency	9.8
31	lymphoma	9.8
32	combined t cell and b cell immunodeficiency	9.8
33	large intestine cancer	9.8	ABCG2 CDX1 CDX2 MTHFR TYMS
34	hematologic cancer	9.6	ABCG2 CD2 CDKN1C CDKN2B CSF3
35	leukemia, acute myeloid	9.4	ABCG2 CD2 CDKN2B CDX4 CSF3

Graphical network of the top 20 diseases related to Adult Acute Lymphocytic Leukemia:

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Symptoms & Phenotypes for Adult Acute Lymphocytic Leukemia

MGI Mouse Phenotypes related to Adult Acute Lymphocytic Leukemia:

⁴⁶

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	homeostasis/metabolism	MP:0005376	9.61	ABCG2 CDKN2B CDX2 CDX4 INPP5D MTHFR
2	neoplasm	MP:0002006	9.02	CDKN2B CDX2 INPP5D SHMT1 TP73

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Drugs & Therapeutics for Adult Acute Lymphocytic Leukemia

FDA approved drugs:

#	Drug Name	Active Ingredient(s) ¹⁸	Company	Approval Date
1	Marqibo ¹⁸ ⁴⁹	VINCRISTINE SULFATE	Talon Therapeutics	August 2012
FDA Label: Marqibo Disease/s that Drug Treats:Ph- acute lymphoblastic leukemia Indications and Usage: ¹⁸ Marqibo is a vinca alkaloid indicated for the treatment of adult patients withPhiladelphia chromosome-negative (Ph-) acute lymphoblastic leukemia (ALL)in second or greater relapse or whose disease has progressed following two ormore anti-leukemia therapies. This indication is based on overall responserate. Clinical benefit such as improvement in overall survival has not beenverified (1.1). DrugBank Targets: ¹⁶ 1. Tubulin beta chain;2. Tubulin alpha-4A chain Mechanism of Action: ¹⁸ Target: tubulin Action: alters polymerization equilibrium FDA: Marqibo is a sphingomyelin/cholesterol liposome-encapsulated formulation of vincristine sulfate.Non-liposomal vincristine sulfate binds to tubulin, altering the tubulin polymerization equilibrium, resulting inaltered microtubule structure and function. Non-liposomal vincristine sulfate stabilizes the spindle apparatus,preventing chromosome segregation, triggering metaphase arrest and inhibition of mitosis.

Drugs for Adult Acute Lymphocytic Leukemia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 414)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Vincristine

Approved, Investigational

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1

57-22-7, 2068-78-2

5978

Teniposide

Approved

Phase 4,Phase 2

29767-20-2

34698

Methotrexate

Approved

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1

59-05-2, 1959-05-2

126941

Prednisone

Approved, Vet_approved

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

53-03-2

5865

Hydrocortisone acetate

Approved, Vet_approved

Phase 4,Phase 3,Phase 2,Phase 1

50-03-3

Cytarabine

Approved, Investigational

Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1

147-94-4

6253

Hydrocortisone

Approved, Vet_approved

Phase 4,Phase 3,Phase 2,Phase 1

50-23-7

5754

Daunorubicin

Approved

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

20830-81-3

30323

Dexamethasone acetate

Approved, Investigational, Vet_approved

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1

1177-87-3

Mitoxantrone

Approved, Investigational

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

65271-80-9

4212

Dexamethasone

Approved, Investigational, Vet_approved

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1

50-02-2

5743

leucovorin

Approved

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1

58-05-9

6006 143

Idarubicin

Approved

Phase 4,Phase 3,Phase 2,Phase 1

58957-92-9

42890

Etoposide

Approved

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

33419-42-0

36462

Cyclophosphamide

Approved, Investigational

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1

6055-19-2, 50-18-0

2907

Prednisolone

Approved, Vet_approved

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

50-24-8

5755

Prednisolone phosphate

Approved, Vet_approved

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

302-25-0

Methylprednisolone

Approved, Vet_approved

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

83-43-2

6741

Fludarabine

Approved

Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable

75607-67-9, 21679-14-1

30751

Methylprednisolone hemisuccinate

Approved

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

2921-57-5

Vindesine

Approved, Investigational

Phase 4,Phase 3,Phase 2,Not Applicable

59917-39-4, 53643-48-4

40839

Thioguanine

Approved

Phase 4,Phase 3,Phase 2,Not Applicable

154-42-7

2723601

Doxorubicin

Approved, Investigational

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1

23214-92-8

31703

Cladribine

Approved, Investigational

Phase 4,Phase 2,Phase 1,Not Applicable

4291-63-8

20279

rituximab

Approved

Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1

174722-31-7

10201696

Lenograstim

Approved, Investigational

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

135968-09-1

Ifosfamide

Approved

Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable

3778-73-2

3690

Thiotepa

Approved, Investigational

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

52-24-4

5453

Folic Acid

Approved, Nutraceutical, Vet_approved

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1

59-30-3

6037

Doxil

Approved June 1999

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1

31703

Prednisolone hemisuccinate

Experimental

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

2920-86-7

6-Mercaptopurine

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

Hydrocortisone 17-butyrate 21-propionate

Phase 4,Phase 3,Phase 2,Phase 1

Hydrocortisone-17-butyrate

Phase 4,Phase 3,Phase 2,Phase 1

Peripheral Nervous System Agents

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

Anti-Bacterial Agents

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1

Anti-Inflammatory Agents

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

Antiviral Agents

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

HIV Protease Inhibitors

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

Antimetabolites

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

Hormones

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

protease inhibitors

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

Vitamin B Complex

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1

Anti-Infective Agents

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1

Autonomic Agents

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

BB 1101

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1

Immunosuppressive Agents

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1

Antimetabolites, Antineoplastic

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

Antineoplastic Agents, Hormonal

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

Cortisol succinate

Phase 4,Phase 3,Phase 2,Phase 1

Interventional clinical trials:

(show top 50) (show all 583)

#	Name	Status	NCT ID	Phase	Drugs
1	Treatment of High Risk Adult Acute Lymphoblastic Leukemia	Unknown status	NCT00853008	Phase 4	Vincristine;Daunorubicin;Prednisone;Mitoxantrone;Cytosine Arabinoside;Dexamethasone;Methotrexate (MTX);Cytarabine;ASP;Mercaptopurine;Teniposide;Hydrocortisone
2	HD-Idarubicin/Etoposide Intensified Conditioning Regimen Allo-HSCT for Adult ALL	Unknown status	NCT01873807	Phase 4	IDA;CTX;VP-16
3	German Multicenter Trial for Treatment of Newly Diagnosed Acute Lymphoblastic Leukemia in Adults (07/2003)	Unknown status	NCT00198991	Phase 4	Cyclophosphamide;Dexamethasone;Vincristine;daunorubicin;Asparaginase;Methotrexate;Cytarabine;Mercaptopurine;G-CSF;Vindesine;VP16;Prednisolone;Adriamycin;Thioguanine;VM26;Idarubicin;Fludarabine;Cladribine
4	German Multicenter Trial for Treatment of Elderly Patients With Newly Diagnosed Acute Lymphoblastic Leukemia	Unknown status	NCT00198978	Phase 4	Cyclophosphamide;Dexamethasone / Prednisolone;Cytarabine;Idarubicin;Granulocyte-Colony-Stimulating Factor;Mercaptopurine;Methotrexate;Rituximab;HDARAC;Vincristine;Depocyte;Asparaginase
5	Rituximab Plus Chemotherapy for CD20+ Adult Acute Lymphoblastic Leukemia	Completed	NCT01358253	Phase 4	Cyclophosphamide;Doxorubicin;Vincristine;Dexamethasone;Cytarabine;Methotrexate;Rituximab;6-Mercaptopurine;Prednisone;L-asparaginase
6	Treatment of Elderly Patients (>65 Years) With Acute Lymphoblastic Leukemia	Completed	NCT00199095	Phase 4	Adriamycin;Cyclophosphamide;Cytarabine;Dexamethasone;Idarubicin;Ifosfamide;Methotrexate;Mercaptopurine;VM26;Vincristine
7	German Multicenter Trial for Treatment of Newly Diagnosed Acute Lymphoblastic Leukemia in Adults (05/93)	Completed	NCT00199069	Phase 4	Asparaginase;Vincristine;Daunorubicin, Adriamycin;Cyclophosphamide;Ifosfamide;Cytarabine;Mitoxantrone;Methotrexate;6-Mercaptopurine;6-Thioguanine;VM26;Dexamethasone / Prednisolone
8	German Multicenter Trial for Treatment of Newly Diagnosed Acute Lymphoblastic Leukemia in Adults (06/99)	Completed	NCT00199056	Phase 4	Dexamethasone / Prednisolone;Cyclophosphamide;Methotrexate;Vincristine / Vindesine;Daunorubicin;Asparaginase;G-CSF;Cytarabine;6-Mercaptopurine;VP16;Adriamycin;Thioguanine;VM26;Idarubicin;Fludarabine;Ifosfamide
9	Trial for Treatment of Adult Patients With Standard Risk Acute Lymphoblastic Leukemia With Chemotherapy and Rituximab	Completed	NCT00199004	Phase 4	Cyclophosphamide;Dexamethasone / Prednisolone;Vincristine;Daunorubicin;Asparaginase;Methotrexate;Cytarabine;Mercaptopurine;G-CSF;Vindesine;VP16;Adriamycin;Thioguanine;VM26;Rituximab
10	Bone Marrow Transplantation in Treating Patients With Hematologic Cancer	Completed	NCT00003398	Phase 4	cyclophosphamide;thiotepa
11	Phase III Study of Vincristine Sulfate Liposome For Injection In Adults With Naïve Acute Lymphoblastic Leukemia	Unknown status	NCT02072785	Phase 3	Vincristine Sulfate Liposome;Vincristine Sulfate
12	Haplo-identical HSCT Versus Chemotherapy for Adult Acute Lymphoblastic Leukemia Patients	Unknown status	NCT02042690	Phase 3	Chemotherapy
13	Treatment of Acute Lymphoblastic Leukemia or Aggressive Lymphoma With Relapse in Central Nervous System With Depocyt	Unknown status	NCT00199108	Phase 2, Phase 3	Depocyt;Dexamethasone
14	High-Dose Methotrexate (MTX) for Adult Acute Lymphoblastic Leukemia (ALL)	Unknown status	NCT00131027	Phase 3	Cyclophosphamide;Daunorubicin;Vincristine;Prednisolone;L-asparaginase;Cytarabine;Etoposide;Dexamethasone;Methotrexate;Mercaptopurine;Doxorubicin;Methotrexate
15	Pegylated Liposomal Doxorubicin Versus Daunorubicin to Treat Acute Lymphoblastic Leukemia:	Unknown status	NCT02070523	Phase 3	VDCLD regimen
16	Study of US-ATG-F to Prevent Chronic Graft Versus Host Disease (GVHD)	Unknown status	NCT01295710	Phase 3
17	Ketamine Hydrochloride and Best Pain Management in Treating Cancer Patients With Neuropathic Pain	Unknown status	NCT01316744	Phase 3	ketamine hydrochloride
18	Combination Chemotherapy With or Without Idarubicin and Peripheral Stem Cell Transplantation in Treating Patients With Leukemia or Myelodysplastic Syndrome	Unknown status	NCT00002989	Phase 3	busulfan;cyclophosphamide;idarubicin;melphalan
19	Levofloxacin Compared With Cefepime in Treating Cancer Patients With Fever and Neutropenia	Unknown status	NCT00020865	Phase 3	cefepime hydrochloride;levofloxacin
20	Intensified Conditioning Regimen With High-Dose-Etoposide for Allo-HSCT for Adult Acute Lymphoblastic Leukemia	Completed	NCT01457040	Phase 2, Phase 3	TBI+CY+VP-16;FA+TBI+CY+VP-16
21	Intrathecal DepoCyte and Lineage-targeted Minimal Residual Disease-oriented Therapy of Acute Lymphoblastic Leukemia	Completed	NCT00795756	Phase 2, Phase 3	liposome-encapsulated cytarabine (DepoCyte);Triple intrathecal therapy (TIT)
22	Treatment of Hyperuricemia With Rasburicase in Patients With Acute Lymphoblastic Leukemia or High Grade Lymphoma	Completed	NCT00199043	Phase 3	Allopurinol;Rasburicase
23	Treatment of Acute Lymphoblastic Leukemia (ALL) in Younger Adults	Completed	NCT00327678	Phase 3	Rituximab;Imatinib Mesylate
24	Chemotherapy With or Without Bone Marrow Transplantation in Treating Patients With Acute Lymphoblastic Leukemia	Completed	NCT00002700	Phase 3	asparaginase;cyclophosphamide;cytarabine;daunorubicin hydrochloride;dexamethasone;doxorubicin hydrochloride;leucovorin calcium;mercaptopurine;methotrexate;mitoxantrone hydrochloride;prednisolone;prednisone;therapeutic hydrocortisone;vincristine sulfate
25	Low-Dose Prednisone or Methylprednisolone in Treating Patients With Newly Diagnosed Acute Graft-versus-Host Disease	Completed	NCT00929695	Phase 3	prednisone;methylprednisolone
26	Stem Cell Transplantation Compared With Standard Chemotherapy in Treating Patients With Acute Lymphoblastic Leukemia in First Remission	Completed	NCT00002514	Phase 3	asparaginase;cyclophosphamide;cytarabine;daunorubicin hydrochloride;dexamethasone;etoposide;imatinib mesylate;leucovorin calcium;mercaptopurine;methotrexate;prednisone;thioguanine;vincristine sulfate
27	Eculizumab in Treating Patients With Paroxysmal Nocturnal Hemoglobinuria	Completed	NCT00112983	Phase 3
28	Dasatinib and Combination Chemotherapy in Treating Young Patients With Newly Diagnosed Acute Lymphoblastic Leukemia	Completed	NCT00720109	Phase 2, Phase 3	Asparaginase;Cyclophosphamide;Cytarabine;Dasatinib;Daunorubicin Hydrochloride;Dexamethasone;Etoposide;Hydrocortisone Sodium Succinate;Ifosfamide;Leucovorin Calcium;Mercaptopurine;Methotrexate;Methylprednisolone;Pegaspargase;Prednisone;Vincristine Sulfate
29	Dexamethasone Compared With Prednisone During Induction Therapy and MTX With or Without Leucovorin During Maintenance Therapy in Treating Patients With Newly Diagnosed High-Risk Acute Lymphoblastic Leukemia	Completed	NCT00075725	Phase 3	cyclophosphamide;cytarabine;daunorubicin hydrochloride;dexamethasone;doxorubicin hydrochloride;leucovorin calcium;mercaptopurine;methotrexate;pegaspargase;prednisone;thioguanine;vincristine sulfate
30	Internet-Based Program With or Without Telephone-Based Problem-Solving Training in Helping Long-Term Survivors of Hematopoietic Stem Cell Transplant Cope With Late Complications	Completed	NCT00799461	Phase 3
31	Comparison of Two Combination Chemotherapy Regimens in Treating Adults With Previously Untreated Leukemia or Lymphoma	Completed	NCT00002766	Phase 3	carmustine;cyclophosphamide;cytarabine;daunorubicin hydrochloride;doxorubicin hydrochloride;etoposide;mercaptopurine;methotrexate;mitoxantrone hydrochloride;pegaspargase;prednisone;vincristine sulfate
32	Personalized Information or Basic Information in Helping Patients Make Decisions About Participating in a Clinical Trial	Completed	NCT00750009	Phase 3
33	American Ginseng in Treating Patients With Fatigue Caused by Cancer	Completed	NCT00719563	Phase 3	American ginseng
34	Darbepoetin Alfa With or Without Iron in Treating Anemia Caused By Chemotherapy in Patients With Cancer	Completed	NCT00661999	Phase 3	sodium ferric gluconate complex in sucrose
35	Fentanyl Sublingual Spray in Treating Patients With Breakthrough Cancer Pain	Completed	NCT00538850	Phase 3	Fentanyl sublingual spray;Placebo
36	Bone Marrow Transplantation in Treating Patients With Leukemia, Myelodysplasia, or Lymphoblastic Lymphoma	Completed	NCT00003187	Phase 2, Phase 3	cyclophosphamide;cyclosporine;cytarabine;methotrexate;methylprednisolone
37	St. John's Wort in Relieving Fatigue in Patients Undergoing Chemotherapy or Hormone Therapy for Cancer	Completed	NCT00005805	Phase 3
38	Dalteparin to Prevent Complications in Cancer Patients Receiving Chemotherapy Through a Catheter	Completed	NCT00006083	Phase 3	Fragmin
39	Valacyclovir in Preventing Cytomegalovirus Infection in Patients Who Are Undergoing Donor Stem Cell Transplantation	Completed	NCT00045292	Phase 3	acyclovir;acyclovir sodium;valacyclovir
40	Treatment for Chronic Pain in Patients With Advanced Cancer	Completed	NCT00003687	Phase 3	dextromethorphan hydrobromide;morphine sulfate
41	Opioid Titration Order Sheet or Standard Care in Treating Patients With Cancer Pain	Completed	NCT00666211	Phase 3
42	Bone Marrow Transplantation in Treating Patients With Acute Leukemia in First or Second Remission	Completed	NCT00002534	Phase 3	cyclophosphamide;cytarabine;methylprednisolone;thiotepa
43	Treatment of Bone Marrow to Prevent Graft-Versus-Host Disease in Patients With Acute or Chronic Leukemia Undergoing Bone Marrow Transplantation	Completed	NCT00004255	Phase 2, Phase 3	cyclophosphamide;fludarabine phosphate;methylprednisolone;tacrolimus
44	Music Therapy or Book Discussion in Improving Quality of Life in Young Patients Undergoing Stem Cell Transplant	Completed	NCT00305851	Phase 3
45	Laboratory-Treated Donor Bone Marrow in Treating Patients Who Are Undergoing a Donor Bone Marrow Transplant for Hematologic Cancer	Completed	NCT00265837	Phase 3
46	Ondansetron in Treating Patients With Advanced Cancer and Chronic Nausea and Vomiting Not Caused by Cancer Treatment	Completed	NCT00006348	Phase 3	ondansetron
47	Prevention of Infection in Patients With Hematologic Cancer and Persistent Fever Caused by a Low White Blood Cell Count	Completed	NCT00003805	Phase 3	piperacillin sodium;piperacillin-tazobactam;tazobactam sodium;vancomycin
48	Caspofungin Acetate Compared With Amphotericin B Liposomal in Treating Patients With Persistent Fever and Neutropenia Following Cancer Treatment	Completed	NCT00008359	Phase 3	caspofungin acetate;liposomal amphotericin B
49	Liposomal Amphotericin B in Treating Granulocytopenia and Persistent Unexplained Fever in Cancer Patients	Completed	NCT00003938	Phase 3	liposomal amphotericin B
50	Combination Chemotherapy in Treating Patients With Non-Hodgkin's Lymphoma or Acute Lymphocytic Leukemia	Completed	NCT00005977	Phase 3	cyclophosphamide;cytarabine;dexamethasone;doxorubicin hydrochloride;etoposide;ifosfamide;leucovorin calcium;methotrexate;vincristine sulfate

Search NIH Clinical Center for Adult Acute Lymphocytic Leukemia

Cell-based therapeutics:

Data from LifeMap, the Embryonic Development and Stem Cells Database

Read about Adult Acute Lymphocytic Leukemia cell therapies at LifeMap Discovery.

Stem-cell-based therapeutic approaches for Adult Acute Lymphocytic Leukemia:

	Hematopoietic stem cells for treatment of hematologic malignancies
	Peripheral blood stem cells for treatment of hematologic malignancies

Embryonic/Adult Cultured Cells Related to Adult Acute Lymphocytic Leukemia:

	Bone marrow-derived hematopoietic stem cells
	Peripheral blood-derived hematopoietic stem cells (family)

Sources

Genetic Tests for Adult Acute Lymphocytic Leukemia

Sources

Anatomical Context for Adult Acute Lymphocytic Leukemia

MalaCards organs/tissues related to Adult Acute Lymphocytic Leukemia:

⁴¹

Bone, Bone Marrow, B Cells, Testes, Myeloid, T Cells, Breast

Data from LifeMap, the Embryonic Development and Stem Cells Database

Cells/anatomical compartments in embryo or adult related to Adult Acute Lymphocytic Leukemia:

#	Tissue Anatomical CompartmentCell	Relevance
1	Blood Hematopoietic Bone Marrow Hematopoietic Stem Cells	Potential therapeutic candidate
2	Blood Peripheral Blood Mature B-Cells	Affected by disease
3	Blood Hematopoietic Bone Marrow Small Pre B-Cells	Affected by disease

Sources

Publications for Adult Acute Lymphocytic Leukemia

Articles related to Adult Acute Lymphocytic Leukemia:

(show top 50) (show all 71)

#	Title	Authors	Year
1	Efficacy and Safety of Vincristine Sulfate Liposome Injection in the Treatment of Adult Acute Lymphocytic Leukemia. ( 27328933 )		2016
2	The Effect of GVHD on Long-term Outcomes after Peripheral Blood Allogeneic Stem Cell Transplantation from an HLA-identical Sibling in Adult Acute Lymphocytic Leukemia: A Landmark Analysis Approach in Competing Risks. ( 24800032 )	Jalali A....Ghavamzadeh A.	2014
3	Serum peptidome based biomarkers searching for monitoring minimal residual disease in adult acute lymphocytic leukemia. ( 25317080 )	Bai J....Zhou F.	2014
4	Medical history, lifestyle, family history, and occupational risk factors for adult acute lymphocytic leukemia: the InterLymph Non-Hodgkin Lymphoma Subtypes Project. ( 25174033 )	Skibola C.F....Weisenburger D.D.	2014
5	[Expression and clinical significance of caudal type homeobox transcription factor-2 in adult acute lymphocytic leukemia]. ( 21518475 )	Lu H.Y....Cheng X.	2011
6	Surface antigens analysis reveals significant expression of candidate targets for immunotherapy in adult acute lymphoid leukemia. ( 21077738 )	Piccaluga PP...Pileri SA	2011
7	Novel targets for treatment of adult acute lymphocytic leukemia. ( 20680526 )	Kasner M.T.	2010
8	Allogeneic hematopoietic stem cell transplantation for adult acute lymphocytic leukemia. ( 20425427 )	Terwey T.H....Arnold R.	2009
9	Allogeneic hematopoietic stem cell transplantation in adult acute lymphocytic leukemia: impact of donor source on survival. ( 19041062 )		2008
10	Long-term molecular complete remission with IFN-alpha in Ph+ adult acute lymphoid leukemia patients. ( 18273047 )	Piccaluga PP...Visani G	2008
11	[Gene expression of breast cancer resistance protein in adult acute lymphocytic leukemia and its clinical significance]. ( 18315895 )		2008
12	Phase II study of sphingosomal vincristine in patients with recurrent or refractory adult acute lymphocytic leukemia. ( 16331634 )	Thomas D.A....Kantarjian H.	2006
13	Protein expression of a triad of frequently methylated genes, p73, p57Kip2, and p15, has prognostic value in adult acute lymphocytic leukemia independently of its methylation status. ( 15851765 )	Bueso-Ramos C....Garcia-Manero G.	2005
14	Gene expression profiles of B-lineage adult acute lymphocytic leukemia reveal genetic patterns that identify lineage derivation and distinct mechanisms of transformation. ( 16243790 )	Chiaretti S....Ritz J.	2005
15	Long-term follow-up results of hyperfractionated cyclophosphamide, vincristine, doxorubicin, and dexamethasone (Hyper-CVAD), a dose-intensive regimen, in adult acute lymphocytic leukemia. ( 15481055 )	Kantarjian H....Freireich E.J.	2004
16	Treatment outcome of adult acute lymphocytic leukemia with VPD(L) regimen: analysis of prognostic factors. ( 12760264 )	Park S.R....Kim N.K.	2003
17	Aberrant DNA methylation of p57KIP2 identifies a cell-cycle regulatory pathway with prognostic impact in adult acute lymphocytic leukemia. ( 12586619 )	Shen L....Garcia-Manero G.	2003
18	DNA methylation patterns at relapse in adult acute lymphocytic leukemia. ( 12060634 )	Garcia-Manero G....Issa J.P.	2002
19	DNA methylation of multiple promoter-associated CpG islands in adult acute lymphocytic leukemia. ( 12114423 )	Garcia-Manero G....Issa J.P.	2002
20	Polymorphisms in the thymidylate synthase and serine hydroxymethyltransferase genes and risk of adult acute lymphocytic leukemia. ( 11986237 )	Skibola C.F....Morgan G.J.	2002
21	Rare adult acute lymphocytic leukemia with CD56 expression in the ECOG experience shows unexpected phenotypic and genotypic heterogeneity. ( 11279625 )	Paietta E....Wiernik P.H.	2001
22	Central nervous system involvement in adult acute lymphocytic leukemia. ( 11253605 )		2001
23	High-dose anthracycline induction in adult acute lymphocytic leukemia. ( 11253610 )		2001
24	Adult acute lymphocytic leukemia. Future research directions. ( 11253607 )		2001
25	Cytogenetic aberrations in adult acute lymphocytic leukemia: optimal technique may influence the results. ( 11454422 )		2001
26	Induction therapy of adult acute lymphocytic leukemia without the use of vincristine or prednisone. ( 11253603 )		2001
27	Results of treatment with hyper-CVAD, a dose-intensive regimen, in adult acute lymphocytic leukemia. ( 10653870 )	Kantarjian H.M....Freireich E.J.	2000
28	The Medical Research Council trials in adult acute lymphocytic leukemia. ( 11147226 )	Durrant I.J....Goldstone A.H.	2000
29	The hyper-CVAD regimen in adult acute lymphocytic leukemia. ( 11147229 )	Garcia-Manero G....Kantarjian H.M.	2000
30	Insights into the biologic and molecular abnormalities in adult acute lymphocytic leukemia. ( 11147223 )	Faderl S....Albitar M.	2000
31	Adult acute lymphocytic leukemia study testing chemotherapy and autologous and allogeneic transplantation. A follow-up report of the French protocol LALA 87. ( 11147227 )	Thiebaut A....FiA"re D.	2000
32	Adult acute lymphocytic leukemia. Introduction and questions related to current programs. ( 11147219 )		2000
33	Cytogenetics in adult acute lymphocytic leukemia. ( 11147221 )		2000
34	Immunophenotypes in adult acute lymphocytic leukemia. Role of flow cytometry in diagnosis and monitoring of disease. ( 11147222 )	Huh YO...Ibrahim S	2000
35	Familial neurofibromatosis type I and adult acute lymphocytic leukemia. ( 10329933 )		1999
36	Deletions and losses in chromosomes 5 or 7 in adult acute lymphocytic leukemia: incidence, associations and implications. ( 10360374 )		1999
37	Analysis of the BCR-ABL protein in Philadelphia chromosome-positive adult acute lymphocytic leukemia. ( 9305617 )	Bseiso A.W....Arlinghaus R.	1997
38	Avascular necrosis of bone after adult acute lymphocytic leukemia treatment with methotrexate, vincristine, L-asparaginase, and dexamethasone (MOAD). ( 8756084 )	Hui L....Wiernik P.H.	1996
39	Myeloid markers in adult acute lymphocytic leukemia. Correlations with patient and disease characteristics and with prognosis. ( 8635059 )	Preti H.A....Kantarjian H.M.	1995
40	Growth and biologic properties of karyotypically defined subcategories of adult acute lymphocytic leukemia in mice with severe combined immunodeficiency. ( 7492788 )		1995
41	Adult acute lymphocytic leukemia: critical review of current knowledge. ( 8059784 )	Kantarjian H.M.	1994
42	Management of adult acute lymphocytic leukemia: present issues and key challenges. ( 8201394 )	Preti A....Kantarjian H.M.	1994
43	Philadelphia-chromosome-positive adult acute lymphocytic leukemia: characteristics, treatment results, and prognosis in 41 patients. ( 8030658 )	Preti H.A....Kantarjian H.M.	1994
44	Serum beta 2-microglobulin in adult acute lymphocytic leukemia. ( 8166167 )	Anand A	1994
45	Late intensification therapy in adult acute lymphoid leukemia: long-term follow-up of the Southeastern Cancer Study Group experience. ( 7858504 )	Omura GA...Bartolucci AA	1994
46	The role of bone marrow transplantation in adult acute lymphocytic leukemia. ( 8338797 )	Dicke K.A....Gale R.P.	1993
47	Long-term follow-up of treatment and potential cure of adult acute lymphocytic leukemia with MOAD: a non-anthracycline containing regimen. ( 8350624 )	Wiernik P.H....Benson L.	1993
48	Adult acute lymphocytic leukemia: the Eastern Cooperative Oncology Group experience. ( 1578927 )	Cassileth P.A....Wiernik P.	1992
49	Prognostic significance of elevated serum beta 2-microglobulin levels in adult acute lymphocytic leukemia. ( 1466355 )	Kantarjian H.M....Keating M.J.	1992
50	Treatment of relapsed or refractory adult acute lymphocytic leukemia. ( 1730121 )	Freund M....Kuse R.	1992

Sources

Genes for Adult Acute Lymphocytic Leukemia

Genes related to Adult Acute Lymphocytic Leukemia (0 elite genes):

(show all 14)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubmedIds
1	SHMT1	Serine Hydroxymethyltransferase 1	Protein Coding	30.62	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵ GeneCards inferred via : Publications (show sections)	12604405
2	CDKN2B	Cyclin Dependent Kinase Inhibitor 2B	Protein Coding	27.43	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵ GeneCards inferred via : Publications (show sections)	9041182 15851765
3	TYMS	Thymidylate Synthetase	Protein Coding	25.66	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵ GeneCards inferred via : Publications (show sections)	11986237 12604405
4	CDKN1C	Cyclin Dependent Kinase Inhibitor 1C	Protein Coding	21.15	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
5	CDX1	Caudal Type Homeobox 1	Protein Coding	20.21	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
6	TP73	Tumor Protein P73	Protein Coding	16.86	GeneCards inferred via : Publications (show sections)
7	CDX2	Caudal Type Homeobox 2	Protein Coding	16.86	GeneCards inferred via : Publications (show sections)
8	ABCG2	ATP Binding Cassette Subfamily G Member 2 (Junior Blood Group)	Protein Coding	16.86	GeneCards inferred via : Publications (show sections)
9	MTR	5-Methyltetrahydrofolate-Homocysteine Methyltransferase	Protein Coding	16.86	GeneCards inferred via : Publications (show sections)
10	MTHFR	Methylenetetrahydrofolate Reductase	Protein Coding	16.86	GeneCards inferred via : Publications (show sections)
11	CD2	CD2 Molecule	Protein Coding	15.52	DISEASES inferred ¹⁵
12	INPP5D	Inositol Polyphosphate-5-Phosphatase D	Protein Coding	15.29	DISEASES inferred ¹⁵
13	CDX4	Caudal Type Homeobox 4	Protein Coding	11.41	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
14	CSF3	Colony Stimulating Factor 3	Protein Coding	10.3	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)

Sources

Variations for Adult Acute Lymphocytic Leukemia

Sources

Expression for Adult Acute Lymphocytic Leukemia

Search GEO for disease gene expression data for Adult Acute Lymphocytic Leukemia.

Sources

Pathways for Adult Acute Lymphocytic Leukemia

Pathways related to Adult Acute Lymphocytic Leukemia according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Selenium Micronutrient Network ¹ Show member pathways Folate Metabolism ¹ Metabolism of ingested MeSeO2H into MeSeH ⁶⁶ thioredoxin pathway ¹ Vitamin B12 Metabolism ¹	11.88	MTHFR MTR SHMT1
2	Carbon metabolism ³⁷ Show member pathways 2-Oxocarboxylic acid metabolism ³⁷ Biosynthesis of amino acids ³⁷ formaldehyde oxidation ¹	11.82	MTHFR MTR SHMT1
3	Pyrimidine metabolism ⁶⁶ Show member pathways Fluoropyrimidine Activity ¹ Fluoropyrimidine Pathway, Pharmacodynamics ⁶¹ Fluoropyrimidine Pathway, Pharmacokinetics ⁶¹ glutamate removal from folates ¹ Pyrimidine biosynthesis ⁶⁶ Pyrimidine catabolism ⁶⁶ pyrimidine ribonucleosides degradation ¹ pyrimidine ribonucleosides salvage I ¹ Pyrimidine salvage reactions ⁶⁶ UMP biosynthesis ¹	11.56	ABCG2 MTHFR TYMS
4	Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers ⁶⁵	11.46	CDX1 CDX2 CDX4
5	One carbon pool by folate ³⁷ Show member pathways Antimetabolite Pathway - Folate Cycle, Pharmacodynamics ⁶¹ dTMP de novo biosynthesis (mitochondrial) ¹ folate transformations I ¹ Methionine metabolism ²² methionine salvage ¹ Methotrexate Pathway (Cancer Cell), Pharmacodynamics ⁶¹ One Carbon Metabolism ¹ tetrahydrofolate salvage from 5,10-methenyltetrahydrofolate ¹ Trans-sulfuration and one carbon metabolism ¹	11.41	MTHFR MTR SHMT1 TYMS
6	Antifolate resistance ³⁷	10.42	ABCG2 MTHFR SHMT1 TYMS

Sources

GO Terms for Adult Acute Lymphocytic Leukemia

Biological processes related to Adult Acute Lymphocytic Leukemia according to GeneCards Suite gene sharing:

(show all 17)

#	Name	GO ID	Score	Top Affiliating Genes
1	response to drug	GO:0042493	9.76	ABCG2 MTHFR TP73 TYMS
2	cell cycle arrest	GO:0007050	9.7	CDKN1C CDKN2B TP73
3	anterior/posterior pattern specification	GO:0009952	9.65	CDX1 CDX2 CDX4
4	regulation of mitotic cell cycle	GO:0007346	9.57	CDKN1C TP73
5	protein tetramerization	GO:0051262	9.56	SHMT1 TP73
6	positive regulation of transforming growth factor beta receptor signaling pathway	GO:0030511	9.55	CDKN1C CDKN2B
7	one-carbon metabolic process	GO:0006730	9.54	MTHFR SHMT1
8	folic acid metabolic process	GO:0046655	9.51	MTHFR SHMT1
9	negative regulation of phosphorylation	GO:0042326	9.49	CDKN1C CDKN2B
10	methionine biosynthetic process	GO:0009086	9.43	MTHFR MTR
11	labyrinthine layer development	GO:0060711	9.4	CDX2 CDX4
12	response to folic acid	GO:0051593	9.37	MTHFR TYMS
13	placenta development	GO:0001890	9.33	CDKN1C CDX2 CDX4
14	regulation of somitogenesis	GO:0014807	9.32	CDX1 CDX2
15	dTMP biosynthetic process	GO:0006231	9.26	SHMT1 TYMS
16	tetrahydrofolate interconversion	GO:0035999	9.13	MTHFR SHMT1 TYMS
17	tetrahydrofolate metabolic process	GO:0046653	8.8	MTHFR SHMT1 TYMS

Molecular functions related to Adult Acute Lymphocytic Leukemia according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	methyl-CpG binding	GO:0008327	9.16	CDX1 CDX2
2	translation repressor activity, mRNA regulatory element binding	GO:0000900	8.96	SHMT1 TYMS
3	cyclin-dependent protein serine/threonine kinase inhibitor activity	GO:0004861	8.62	CDKN1C CDKN2B

Sources

Sources for Adult Acute Lymphocytic Leukemia

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ ExPASy

¹⁸ FDA Approved Drugs

¹⁹ FMA

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ Genetics Home Reference

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HGMD

³¹ HMDB

³² HPO

³³ ICD10

³⁴ ICD10 via Orphanet

³⁵ ICD9CM

³⁶ IUPHAR

³⁷ KEGG

³⁸ LifeMap

³⁹ LncRNADisease

⁴⁰ LOVD

⁴¹ MalaCards

⁴² MedGen

⁴³ MedlinePlus

⁴⁴ MeSH

⁴⁵ MESH via Orphanet

⁴⁶ MGI

⁴⁷ miR2Disease

⁴⁸ NCBI Bookshelf

⁴⁹ NCI

⁵⁰ NCIt

⁵¹ NDF-RT

⁵² NIH Clinical Center

⁵³ NIH Rare Diseases

⁵⁴ NINDS

⁵⁵ Novoseek

⁵⁶ Novus Biologicals

⁵⁷ OMIM

⁵⁸ OMIM via Orphanet

⁵⁹ Orphanet

⁶⁰ PathCards

⁶¹ PharmGKB

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ SNOMED-CT via Orphanet

⁷¹ TGDB

⁷² Tocris

⁷³ UMLS

⁷⁴ UMLS via Orphanet

⁷⁵ UniProtKB/Swiss-Prot

⁷⁶ Wikipedia