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MCID: ADL052
MIFTS: 46

Adult Acute Lymphocytic Leukemia

Categories: Blood diseases, Bone diseases, Cancer diseases, Immune diseases, Rare diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Adult Acute Lymphocytic Leukemia

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MalaCards integrated aliases for Adult Acute Lymphocytic Leukemia:

Name: Adult Acute Lymphocytic Leukemia 12 54 15 37 71
Adult Acute Lymphoid Leukemia 12
Adult All 12

Classifications:

MalaCards categories:
Global: Cancer diseases Rare diseases
Anatomical: Blood diseases Immune diseases Bone diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:5604
NCIt 50 C4967
UMLS 71 C0751606
Sources

Summaries for Adult Acute Lymphocytic Leukemia

About this section
Disease Ontology : 12 An acute lymphocytic leukemia occurring during adulthood.

MalaCards based summary : Adult Acute Lymphocytic Leukemia, also known as adult acute lymphoid leukemia, is related to t-cell adult acute lymphocytic leukemia and b-cell adult acute lymphocytic leukemia. An important gene associated with Adult Acute Lymphocytic Leukemia is SHMT1 (Serine Hydroxymethyltransferase 1), and among its related pathways/superpathways are One carbon pool by folate and Innate Lymphoid Cell Differentiation Pathways. The drugs Cladribine and Sargramostim have been mentioned in the context of this disorder. Affiliated tissues include Blood, and related phenotypes are Decreased viability and Decreased viability

Sources

Related Diseases for Adult Acute Lymphocytic Leukemia

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Diseases in the Leukemia, Chronic Lymphocytic family:

Leukemia, Chronic Lymphocytic 2 Leukemia, Chronic Lymphocytic 1
Leukemia, Chronic Lymphocytic 3 Leukemia, Chronic Lymphocytic 4
Leukemia, Chronic Lymphocytic 5 Adult Acute Lymphocytic Leukemia

Diseases related to Adult Acute Lymphocytic Leukemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 102)
# Related Disease Score Top Affiliating Genes
1 t-cell adult acute lymphocytic leukemia 33.0 HBZ CD4 CCR6
2 b-cell adult acute lymphocytic leukemia 32.6 PBX1 IKZF1 ABL1
3 t-cell acute lymphoblastic leukemia 31.4 IKZF1 ETV6 CSF3 CDKN2B ABL1
4 mucositis 30.8 TYMS MTHFR CSF3
5 b-lymphoblastic leukemia/lymphoma 30.3 TP73 PBX1 ETV6 CDKN2B CCR6 ABL1
6 acute leukemia 30.3 PBX1 MTHFR ETV6 CSF3 CDKN2B AFF1
7 leukemia 30.2 PBX1 MTHFR IKZF1 ETV6 AFF1 ABL1
8 precursor t-cell acute lymphoblastic leukemia 30.2 IKZF1 ETV6 CDKN2B ABL1
9 leukemia, chronic myeloid 30.1 IKZF1 ETV6 CSF3 CDKN2B ABL1
10 lymphoma, non-hodgkin, familial 30.0 IKZF1 ETV6 CSF3 CDKN2B CD4 CCR6
11 exanthem 29.9 CSF3 CD4 CCR6
12 leukemia, acute myeloid 29.3 PBX1 IKZF1 ETV6 CSF3 CDKN2B CD4
13 leukemia, acute lymphoblastic 29.2 TYMS TP73 PBX1 MTHFR IKZF1 HBZ
14 hemifacial spasm 10.5 TYMS MTHFR
15 sudden sensorineural hearing loss 10.4 MTR MTHFR
16 homocystinuria due to deficiency of n -methylenetetrahydrofolate reductase activity 10.4 MTR MTHFR
17 bartholin's gland disease 10.4 CDX2 CDX1
18 bartholin's gland carcinoma 10.4 CDX2 CDX1
19 methotrexate toxicity 10.4 TYMS MTR MTHFR
20 gastroesophageal adenocarcinoma 10.4 TYMS MTR MTHFR
21 pediatric osteosarcoma 10.4 SHMT1 MTR MTHFR
22 ascending colon cancer 10.4 CSF3 CDX2
23 pyomyositis 10.4 CSF3 CD4
24 b-lymphoblastic leukemia/lymphoma, bcr-abl1-like 10.4 IKZF1 ABL1
25 splenic abscess 10.4 CSF3 CD4
26 hepatic vascular disease 10.3 MTHFR CSF3 CCR6
27 aniseikonia 10.3 CSF3 CD4
28 suppurative lymphadenitis 10.3 CD4 CCR6
29 myeloid and lymphoid neoplasms associated with pdgfra rearrangement 10.3 ETV6 ABL1
30 herpes simplex virus keratitis 10.3 CD4 CCR6
31 mental retardation, autosomal dominant 29 10.3 PBX1 ABL1
32 intracranial vasospasm 10.3 MTR MTHFR
33 scabies 10.3 CSF3 CD4 CCR6
34 mucormycosis 10.3 CSF3 CD4 CCR6
35 mikulicz disease 10.3 CD4 CCR6
36 nail disorder, nonsyndromic congenital, 1 10.3 ETV6 CCR6 ABCG2
37 central nervous system leukemia 10.3 AFF1 ABL1
38 pneumocystosis 10.3 CSF3 CD4 CCR6
39 testicular leukemia 10.3 ETV6 ABL1
40 cellulitis 10.3 CSF3 CD4 CCR6
41 macroglossia 10.3 CSF3 CDKN1C
42 opportunistic mycosis 10.3 CSF3 CD4 CCR6
43 autoimmune disease of cardiovascular system 10.3 MTHFR CD4 CCR6
44 vein disease 10.3 MTHFR CD4 CCR6
45 fungal infectious disease 10.3 CSF3 CD4 CCR6
46 chancroid 10.3 CD4 CCR6
47 gastrointestinal carcinoma 10.3 TYMS MTHFR CDX2 CDX1
48 autonomic dysfunction 10.3 SHMT1 MTHFR
49 stomatitis 10.3 TYMS CSF3 CD4
50 anti-basement membrane glomerulonephritis 10.3 CD4 CCR6

Graphical network of the top 20 diseases related to Adult Acute Lymphocytic Leukemia:



Diseases related to Adult Acute Lymphocytic Leukemia
Sources

Symptoms & Phenotypes for Adult Acute Lymphocytic Leukemia

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GenomeRNAi Phenotypes related to Adult Acute Lymphocytic Leukemia according to GeneCards Suite gene sharing:

26 (show all 13)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00221-A-1 9.64 ABL1
2 Decreased viability GR00221-A-2 9.64 ABL1 CDKN1C
3 Decreased viability GR00221-A-3 9.64 ABL1 CDKN1C
4 Decreased viability GR00221-A-4 9.64 CDKN1C
5 Decreased viability GR00240-S-1 9.64 ABCG2
6 Decreased viability GR00249-S 9.64 CDX1 CDX2 PBX1 TP73
7 Decreased viability GR00301-A 9.64 CDKN1C
8 Decreased viability GR00342-S-1 9.64 ABL1
9 Decreased viability GR00342-S-2 9.64 ABL1 CD4
10 Decreased viability GR00342-S-3 9.64 ABL1
11 Decreased viability GR00381-A-1 9.64 AFF1
12 Decreased viability GR00386-A-1 9.64 CSF3 MTHFR TYMS
13 Decreased viability GR00402-S-2 9.64 TP73

MGI Mouse Phenotypes related to Adult Acute Lymphocytic Leukemia:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.21 ABCG2 ABL1 AFF1 CCR6 CD4 CDKN2B
2 homeostasis/metabolism MP:0005376 10.13 ABCG2 ABL1 CCR6 CD4 CDKN2B CDX2
3 endocrine/exocrine gland MP:0005379 10.1 ABL1 AFF1 CD4 CDKN2B CDX1 CDX2
4 digestive/alimentary MP:0005381 10.03 ABL1 CD4 CDX1 CDX2 ETV6 IKZF1
5 immune system MP:0005387 10 ABCG2 ABL1 AFF1 CCR6 CD4 CDKN2B
6 integument MP:0010771 9.81 ABCG2 CD4 CDKN2B CDX1 CSF3 ETV6
7 mortality/aging MP:0010768 9.8 ABL1 AFF1 CD4 CDKN2B CDX2 CDX4
8 normal MP:0002873 9.28 ABCG2 ABL1 CCR6 CD4 CDX1 CDX2
Sources

Drugs & Therapeutics for Adult Acute Lymphocytic Leukemia

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Drugs for Adult Acute Lymphocytic Leukemia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 93)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cladribine Approved, Investigational Phase 4 4291-63-8 20279
2
Sargramostim Approved, Investigational Phase 4 123774-72-1, 83869-56-1
3
Lenograstim Approved, Investigational Phase 4 135968-09-1
4
Daunorubicin Approved Phase 4 20830-81-3 30323
5
Prednisolone Approved, Vet_approved Phase 4 50-24-8 5755
6
Methylprednisolone hemisuccinate Approved Phase 4 2921-57-5
7
Mitoxantrone Approved, Investigational Phase 4 65271-80-9 4212
8
Thioguanine Approved Phase 4 154-42-7 2723601
9 Prednisolone acetate Approved, Vet_approved Phase 4 52-21-1
10
Teniposide Approved Phase 4 29767-20-2 34698
11
Ifosfamide Approved Phase 4 3778-73-2 3690
12
Methylprednisolone Approved, Vet_approved Phase 4 83-43-2 6741
13
Prednisolone phosphate Approved, Vet_approved Phase 4 302-25-0
14
Vindesine Approved, Investigational Phase 4 53643-48-4, 59917-39-4 40839
15
Idarubicin Approved Phase 4 58957-92-9 42890
16
rituximab Approved Phase 4 174722-31-7 10201696
17 Molgramostim Investigational Phase 4 99283-10-0
18
Prednisolone hemisuccinate Experimental Phase 4 2920-86-7
19 Adjuvants, Immunologic Phase 4
20 Analgesics Phase 4
21
Isophosphamide mustard Phase 4 100427
22 Methylprednisolone Acetate Phase 4
23 Antineoplastic Agents, Immunological Phase 4
24
Cytarabine Approved, Investigational Phase 2, Phase 3 147-94-4 6253
25
Methotrexate Approved Phase 2, Phase 3 1959-05-2, 59-05-2 126941
26
Levoleucovorin Approved, Investigational Phase 2, Phase 3 68538-85-2 149436
27
Allopurinol Approved Phase 3 315-30-0 2094
28
Rasburicase Approved, Investigational Phase 3 134774-45-1
29
Folic acid Approved, Nutraceutical, Vet_approved Phase 2, Phase 3 59-30-3 6037
30 Immunologic Factors Phase 2, Phase 3
31 gamma-Globulins Phase 3
32 Immunoglobulins Phase 3
33 Antilymphocyte Serum Phase 3
34 Immunoglobulins, Intravenous Phase 3
35 Antibodies Phase 3
36 Rho(D) Immune Globulin Phase 3
37 Immunosuppressive Agents Phase 2, Phase 3
38 Folic Acid Antagonists Phase 2, Phase 3
39 Vitamin B Complex Phase 2, Phase 3
40 Antimetabolites Phase 2, Phase 3
41 Antirheumatic Agents Phase 2, Phase 3
42 Dermatologic Agents Phase 2, Phase 3
43 Anti-Infective Agents Phase 2, Phase 3
44 Vitamin B9 Phase 2, Phase 3
45 Antiviral Agents Phase 2, Phase 3
46 Folate Phase 2, Phase 3
47 Protective Agents Phase 3
48 Antioxidants Phase 3
49
Prednisone Approved, Vet_approved Phase 2 53-03-2 5865
50
Mesna Approved, Investigational Phase 2 3375-50-6 598

Interventional clinical trials:

(show all 23)
# Name Status NCT ID Phase Drugs
1 German Multicenter Study for Treatment Optimisation in Acute Lymphoblastic Leukemia in Adults and Adolescents Above 15 Years (Amend 3) (GMALL 07/2003) Unknown status NCT00198991 Phase 4 Cyclophosphamide;Dexamethasone;Vincristine;daunorubicin;Asparaginase;Methotrexate;Cytarabine;Mercaptopurine;G-CSF;Vindesine;VP16;Prednisolone;Adriamycin;Thioguanine;VM26;Idarubicin;Fludarabine;Cladribine
2 Multicenter Study To Optimize Treatment in Elderly Patients (> 55 Years, No Upper Age Limit) With Acute Lymphoblastic Leukemia (GMALL Elderly 1/2003)(Amend 2) Unknown status NCT00198978 Phase 4 Cyclophosphamide;Dexamethasone / Prednisolone;Cytarabine;Idarubicin;Granulocyte-Colony-Stimulating Factor;Mercaptopurine;Methotrexate;Rituximab;HDARAC;Vincristine;Depocyte;Asparaginase
3 Multicenter Trial for Treatment of Acute Lymphoblastic Leukemia in Adults (05/93) Completed NCT00199069 Phase 4 Asparaginase;Vincristine;Daunorubicin, Adriamycin;Cyclophosphamide;Ifosfamide;Cytarabine;Mitoxantrone;Methotrexate;6-Mercaptopurine;6-Thioguanine;VM26;Dexamethasone / Prednisolone
4 Multicenter Trial for Treatment of Acute Lymphocytic Leukemia in Adults (Pilot Study 06/99) Completed NCT00199056 Phase 4 Dexamethasone / Prednisolone;Cyclophosphamide;Methotrexate;Vincristine / Vindesine;Daunorubicin;Asparaginase;G-CSF;Cytarabine;6-Mercaptopurine;VP16;Adriamycin;Thioguanine;VM26;Idarubicin;Fludarabine;Ifosfamide
5 German Multicenter Trial for Treatment Optimisation in Acute Lymphoblastic Leukemia in Adults and Adolescents Above 15 Years With Rituximab for Improvement of Prognosis in CD20 Positive Standard Risk ALL (Amend 2) Completed NCT00199004 Phase 4 Cyclophosphamide;Dexamethasone / Prednisolone;Vincristine;Daunorubicin;Asparaginase;Methotrexate;Cytarabine;Mercaptopurine;G-CSF;Vindesine;VP16;Adriamycin;Thioguanine;VM26;Rituximab
6 Pilot Study for Treatment of Elderly Patients (>65 Years) With Acute Lymphoblastic Leukemia Completed NCT00199095 Phase 4 Adriamycin;Cyclophosphamide;Cytarabine;Dexamethasone;Idarubicin;Ifosfamide;Methotrexate;Mercaptopurine;VM26;Vincristine
7 A Phase-2 Clinical Study to Determine the Efficacy and Safety of Depocyt (Cytarabine Liposome Injection) for the Treatment of CNS Relapse in Adult Patients With Acute Lymphoblastic Leukemia or Very Aggressive Lymphoma Unknown status NCT00199108 Phase 2, Phase 3 Depocyt;Dexamethasone
8 Phase 3 Study of US-ATG-F to Prevent Moderate to Severe Chronic GVHD in Adult Acute Myeloid Leukemia, Acute Lymphoid Leukemia, and Myelodysplastic Syndrome Patients After Allogeneic Stem Cell Transplantation From Unrelated Donors Completed NCT01295710 Phase 3
9 Randomised Phase III Trial of Effectivity and Safety of Rasburicase Compared With Allopurinol for Treatment of Hyperuricemia in Patients With Acute Lymphoblastic Leukemia or High-Grade NHL With High Risk of Tumorlysis Syndrome (> 15 Yrs) Completed NCT00199043 Phase 3 Allopurinol;Rasburicase
10 A Randomized Study on CNS Prophylaxis With Liposome-Encapsulated Cytarabine in Association With a Lineage-Targeted and MRD-Oriented Postremission Strategy in Adult ALL Completed NCT00795756 Phase 2, Phase 3 liposome-encapsulated cytarabine (DepoCyte);Triple intrathecal therapy (TIT)
11 Open Label, Non-randomized, Phase II Study on Fractioned Cyclophosphamide, Vincristine, Liposomal Doxorubicin or Doxorubicin, and Dexamethasone (MY HYPER-CVAD) in the Treatment of Relapsed Refractory Adult Acute Lymphoid Leukemia Unknown status NCT00801580 Phase 2 doxorubicin liposomal
12 MULTICENTRE TRIAL OF INTENSIFIED THERAPY FOR ADULT ALL (O5/93) Unknown status NCT00002531 Phase 2 asparaginase;cyclophosphamide;cytarabine;daunorubicin hydrochloride;dexamethasone;doxorubicin hydrochloride;etoposide;ifosfamide;leucovorin calcium;mercaptopurine;methotrexate;mitoxantrone hydrochloride;prednisolone;teniposide;thioguanine;vincristine sulfate;vindesine
13 DFCI ALL Adult Consortium Protocol: Adult ALL Trial Unknown status NCT01005758 Phase 2 cyclophosphamide;cytarabine;dexamethasone;doxorubicin hydrochloride;etoposide phosphate;hydrocortisone sodium succinate;imatinib mesylate;mercaptopurine;methotrexate;methylprednisolone;pegaspargase;prednisolone;prednisone;vincristine sulfate
14 German Multicenter Phase II Trial to Study Effectivity and Feasibility of Alemtuzumab (MabCampath®) in T-ALL and T-Lymphoblastic Lymphomas With Minimal Residual Disease (MRD), in Refractory Relapse or in Primary Failure Completed NCT00199030 Phase 2 Alemtuzumab (MabCampath);Cladribine
15 ALL Adult Consortium Trial: Adult ALL Trial Active, not recruiting NCT00476190 Phase 2 Doxorubicin;Cytarabine;Methotrexate;Vincristine;Cyclophosphamide;Methylprednisone;Hydrocortisone Sodium Succinate;Dexamethasone;6-MP;PEG-Asparaginase;Imatinib;Etoposide;E. coli Asparaginase
16 Anti-CD19 Donor-derived CAR-T Cells for Patients With Relapsed B Cell Malignancies After Hematopoietic Stem Cell Transplantation: a Multi-center, Uncontrolled Trial. Recruiting NCT04516551 Phase 1
17 Comparison of Remission Rate and Leukemic Stem Cell Changes Among Patients With Newly Diagnosed Adult ALL With Liposomal Doxorubicin and Daunorubicin-containing VDCLD Regimen. Unknown status NCT03419494 PLD;DNR
18 Young Adult Acute Lymphoid Leukemia (ALL): Intensification of Pediatric AIEOP LLA-2000 Treatment Completed NCT01156883 asparaginase;cyclophosphamide;cytarabine;daunorubicin hydrochloride;dexamethasone;doxorubicin hydrochloride;ifosfamide;mercaptopurine;methotrexate;methylprednisolone;prednisone;thioguanine;vincristine sulfate;vindesine
19 Genetic Risk Classes in Adult Acute Lymphocytic Leukemia Completed NCT00898261
20 GIMEMA Guidelines for the Treatment of Adult ALL Affected Patients at Diagnosis Completed NCT00537550 Vincristine;Vincristin, Daunorubicine, Asparaginase, Methotrexate
21 Studying the Impact of Exercise on Hot Flashes Using Mobile Fitbit Flex, MENQOL Scale and Hot Flash Diary Completed NCT03236896
22 Behavioral Self-Regulation for Weight Loss in Young Adults Completed NCT00488228
23 Prospective Data Collection Regarding Diagnosis, Treatment and Outcome of Adult ALL Patients and Related Diseases Associated With a Prospective Collection of Biomaterial Recruiting NCT02872987

Search NIH Clinical Center for Adult Acute Lymphocytic Leukemia

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Adult Acute Lymphocytic Leukemia cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Adult Acute Lymphocytic Leukemia:
Hematopoietic stem cells for treatment of hematologic malignancies
Peripheral blood stem cells for treatment of hematologic malignancies
Embryonic/Adult Cultured Cells Related to Adult Acute Lymphocytic Leukemia:
Bone marrow-derived hematopoietic stem cells
Peripheral blood-derived hematopoietic stem cells (family)
Sources

Genetic Tests for Adult Acute Lymphocytic Leukemia

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Anatomical Context for Adult Acute Lymphocytic Leukemia

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MalaCards organs/tissues related to Adult Acute Lymphocytic Leukemia:

40
Bone Marrow, Myeloid, B Cells, T Cells, Spinal Cord, Eye, Cortex
LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database

Cells/anatomical compartments in embryo or adult related to Adult Acute Lymphocytic Leukemia:
# Tissue Anatomical CompartmentCell Relevance
1 Blood Hematopoietic Bone Marrow Hematopoietic Stem Cells Potential therapeutic candidate
2 Blood Peripheral Blood Mature B-Cells Affected by disease
3 Blood Hematopoietic Bone Marrow Small Pre B-Cells Affected by disease
Sources

Publications for Adult Acute Lymphocytic Leukemia

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Articles related to Adult Acute Lymphocytic Leukemia:

(show top 50) (show all 934)
# Title Authors PMID Year
1
Protein expression of a triad of frequently methylated genes, p73, p57Kip2, and p15, has prognostic value in adult acute lymphocytic leukemia independently of its methylation status. 61 54
15851765 2005
2
Associations between polymorphisms in the thymidylate synthase and serine hydroxymethyltransferase genes and susceptibility to malignant lymphoma. 54 61
12604405 2003
3
Polymorphisms in the thymidylate synthase and serine hydroxymethyltransferase genes and risk of adult acute lymphocytic leukemia. 54 61
11986237 2002
4
Distinct patterns of inactivation of p15INK4B and p16INK4A characterize the major types of hematological malignancies. 54 61
9041182 1997
5
Pretreatment grade 4 thrombocytopenia is an independent prognostic factor in adult acute lymphoblastic leukemia: an extended analysis of a single-center retrospective study. 61
33357100 2021
6
Allogeneic Hematopoietic Stem-Cell Transplantation Improves Disease-Free Survival Compared to Pediatric-Inspired Berlin-Frankfurt-Münster Chemotherapy in Adult Acute Lymphoblastic Leukemia. 61
33451957 2021
7
The Impact of Obesity on the Outcomes of Adult Patients with Acute Lymphoblastic Leukemia - A Single Center Retrospective Study. 61
33519255 2021
8
Systematic Review of the Burden and Treatment Patterns of Adult and Adolescent Acute Lymphoblastic Leukemia in India: Comprehending the Challenges in an Emerging Economy. 61
33189603 2021
9
Tisagenlecleucel infusion in patients with relapsed/refractory ALL and concurrent serious infection. 61
33472856 2021
10
[Gene Mutation in Acute Lymphoblastic Leukemia by DNA Sequencing]. 61
33283700 2020
11
Value of pre-transplant consolidation chemotherapy in adults with acute lymphoblastic leukemia undergoing allogeneic hematopoietic stem cell transplantation without minimal residual disease in first complete remission. 61
33174792 2020
12
The evolution of relapse of adult T cell acute lymphoblastic leukemia. 61
33225950 2020
13
Incidence, risk factors and outcome of extramedullary relapse after allogeneic hematopoietic stem cell transplantation in patients with adult acute lymphoblastic leukemia. 61
32889611 2020
14
Measurable Residual Disease Assessment and Allogeneic Transplantation as Consolidation Therapy in Adult Acute Lymphoblastic Leukemia in Colombia. 61
33277225 2020
15
Chemotherapy or Allogeneic Transplantation in High-Risk Philadelphia Chromosome-Negative Adult Lymphoblastic Leukemia. 61
33150388 2020
16
Acute lymphoblastic leukaemia (ALL) things come to those who wait: 60 years of progress in the treatment of adult ALL. 61
33190258 2020
17
At three years, patients with acute lymphoblastic leukaemia are still at risk for relapse. Results of the international MRC UKALLXII/ECOG E2993 trial. 61
32220069 2020
18
Contribution of Matrix Metalloproteinase-9 rs3918242 Genotypes to Childhood Leukemia Risk. 61
32988902 2020
19
Managing toxicities with asparaginase-based therapies in adult ALL: summary of an ESMO Open-Cancer Horizons roundtable discussion. 61
33037033 2020
20
Role of Allogeneic HCT as Postremission Therapy for Transplant-Eligible Adult Lymphoblastic Leukemia/Lymphoma After Frontline Hyper-CVAD. 61
32636149 2020
21
Detection of Pathogenic Isoforms of IKZF1 in Leukemic Cell Lines and Acute Lymphoblastic Leukemia Samples: Identification of a Novel Truncated IKZF1 Transcript in SUP-B15. 61
33126432 2020
22
Prognostic factors for survival after allogeneic transplantation in acute lymphoblastic leukemia. 61
33130821 2020
23
National Italian Delphi panel consensus: which measures are indicated to minimize pegylated-asparaginase associated toxicity during treatment of adult acute lymphoblastic leukemia? 61
33008391 2020
24
Impact of donor type on long-term graft-versus-host disease-free/relapse-free survival for adult acute lymphoblastic leukemia in first remission. 61
33128028 2020
25
FLT3-ITD and CD135 Over-Expression are Frequent Findings of Poor Survival in Adult Patients With Acute Leukemias. 61
33109387 2020
26
Favorable outcomes of acute leukemias of ambiguous lineage treated with hyperCVAD: a multi-center retrospective study. 61
32676733 2020
27
Geriatric ATV and snowmobile trauma at a rural level 1 trauma center: A blow to the chest. 61
32631617 2020
28
Effect of Sex and Age on Nutritional Content in Wild Axis Deer (Axis axis Erx.) Meat. 61
32887479 2020
29
Regulation of cell activation by A20 through STAT signaling in acute lymphoblastic leukemia. 61
32808859 2020
30
Current treatment strategies for Philadelphia chromosome-positive adult acute lymphoblastic leukemia. 61
32719174 2020
31
Impact of a 22q11.2 Microdeletion on Adult All-Cause Mortality in Tetralogy of Fallot Patients. 61
32348848 2020
32
Monitoring minimal residual/relapsing disease after allogeneic haematopoietic stem cell transplantation in adult patients with acute lymphoblastic leukaemia. 61
32001801 2020
33
VTE prophylaxis in adult ALL patients. 61
32673394 2020
34
The Clinical and Molecular Characteristics of FLT3 Mutations in Chinese De Novo Adolescent and Adult Acute Lymphoblastic Leukemia Patients. 61
32173273 2020
35
Evolving therapy of adult acute lymphoblastic leukemia: state-of-the-art treatment and future directions. 61
32503572 2020
36
Reduced-Intensity Conditioning with Busulfan and Fludarabine for Allogeneic Hematopoietic Stem Cell Transplantation in Acute Lymphoblastic Leukemia. 61
32469169 2020
37
Prognostic significance of serum progranulin level in de novo adult acute lymphoblastic leukemia patients. 61
32006270 2020
38
Biology and Treatment Paradigms in T Cell Acute Lymphoblastic Leukemia in Older Adolescents and Adults. 61
32468488 2020
39
Passet M, Boissel N, Sigaux F, et al; Group for Research on Adult ALL (GRAALL). PAX5 P80R mutation identifies a novel subtype of B-cell precursor acute lymphoblastic leukemia with favorable outcome. Blood. 2019;133(3):280-284. 61
32463891 2020
40
Philadelphia-like acute lymphoblastic leukemia is associated with minimal residual disease persistence and poor outcome. First report of the minimal residual disease-oriented GIMEMA LAL1913. 61
32467145 2020
41
Dendritic Cell Leukemia: a Review. 61
32415624 2020
42
Education inequalities in adult all-cause mortality: first national data for Australia using linked census and mortality data. 61
31581296 2020
43
Cerebral hemispheric glioblastoma with PNET-like morphology and histone H3.3 G34 mutation in younger patients: Report of three rare cases and diagnostic pitfalls. 61
32317528 2020
44
New biomarkers and therapeutic strategies in acute lymphoblastic leukemias: Recent advances. 61
31487068 2020
45
Recent Advances in the Management of Acute Lymphoblastic Leukaemia. 61
32095902 2020
46
Correction to: Serum peptidome based biomarkers searching for monitoring minimal residual disease in adult acute lymphocytic leukemia. 61
33110398 2020
47
Expression and Activity of Dysregulated miRNAs in T-ALL Development and Progression. 61
33293492 2020
48
[State-of-the-art therapy for adult Philadelphia chromosome-negative acute lymphoblastic leukemia]. 61
33162521 2020
49
Adult Ph-positive acute lymphoblastic leukemia-current concepts in cytogenetic abnormalities and outcomes. 61
32905489 2020
50
Application of targeted next generation sequencing for the mutational profiling of patients with acute lymphoblastic leukemia. 61
32550823 2020
Sources

Variations for Adult Acute Lymphocytic Leukemia

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Expression for Adult Acute Lymphocytic Leukemia

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Search GEO for disease gene expression data for Adult Acute Lymphocytic Leukemia.
Sources

Pathways for Adult Acute Lymphocytic Leukemia

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Pathways related to Adult Acute Lymphocytic Leukemia according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
One carbon pool by folate 36
Show member pathways
 11.41 TYMS SHMT1 MTR MTHFR
2
Innate Lymphoid Cell Differentiation Pathways 64
11.34 IKZF1 CD4 CCR6
3
Fluoropyrimidine Activity 1
Show member pathways
 11.21 TYMS MTHFR ABCG2
4
Antifolate resistance 36
10.42 TYMS SHMT1 MTHFR ABCG2
Sources

GO Terms for Adult Acute Lymphocytic Leukemia

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Cellular components related to Adult Acute Lymphocytic Leukemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 chromatin GO:0000785 9.17 TP73 PBX1 IKZF1 ETV6 CDX4 CDX2

Biological processes related to Adult Acute Lymphocytic Leukemia according to GeneCards Suite gene sharing:

(show all 15)
# Name GO ID Score Top Affiliating Genes
1 regulation of transcription, DNA-templated GO:0006355 10.09 TP73 PBX1 ETV6 CDX4 CDX2 CDX1
2 positive regulation of transcription by RNA polymerase II GO:0045944 9.92 TP73 PBX1 ETV6 CSF3 CDX4 CDX1
3 animal organ morphogenesis GO:0009887 9.76 PBX1 CDX4 CDX2 CDX1
4 cell cycle arrest GO:0007050 9.73 TP73 CDKN2B CDKN1C ABL1
5 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.71 CSF3 CD4 ABL1
6 anterior/posterior pattern specification GO:0009952 9.67 PBX1 CDX4 CDX2 CDX1
7 spleen development GO:0048536 9.58 PBX1 CDKN2B ABL1
8 methionine biosynthetic process GO:0009086 9.52 MTR MTHFR
9 labyrinthine layer development GO:0060711 9.51 CDX4 CDX2
10 response to folic acid GO:0051593 9.49 TYMS MTHFR
11 regulation of somitogenesis GO:0014807 9.48 CDX2 CDX1
12 anterior/posterior axis specification GO:0009948 9.43 CDX4 CDX2 CDX1
13 embryo development GO:0009790 9.33 CDX4 CDX2 CDX1
14 tetrahydrofolate metabolic process GO:0046653 9.13 TYMS SHMT1 MTHFR
15 tetrahydrofolate interconversion GO:0035999 8.8 TYMS SHMT1 MTHFR

Molecular functions related to Adult Acute Lymphocytic Leukemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 sequence-specific double-stranded DNA binding GO:1990837 9.77 PBX1 CDX4 CDX2 CDX1 ABL1
2 RNA polymerase II proximal promoter sequence-specific DNA binding GO:0000978 9.7 TP73 PBX1 IKZF1 ETV6 CDX4 CDX2
3 DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001228 9.65 TP73 PBX1 ETV6 CDX4 CDX1
4 translation repressor activity, mRNA regulatory element binding GO:0000900 9.4 TYMS SHMT1
5 RNA polymerase II regulatory region sequence-specific DNA binding GO:0000977 9.35 PBX1 ETV6 CDX4 CDX2 CDX1
6 cyclin-dependent protein serine/threonine kinase inhibitor activity GO:0004861 9.32 CDKN2B CDKN1C
7 DNA-binding transcription factor activity GO:0003700 9.17 TP73 PBX1 IKZF1 ETV6 CDX4 CDX2
Sources

Sources for Adult Acute Lymphocytic Leukemia

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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