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MCID: ADL052
MIFTS: 45

Adult Acute Lymphocytic Leukemia

Categories: Blood diseases, Bone diseases, Cancer diseases, Immune diseases, Rare diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Adult Acute Lymphocytic Leukemia

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MalaCards integrated aliases for Adult Acute Lymphocytic Leukemia:

Name: Adult Acute Lymphocytic Leukemia 39 12 56 15 74
Adult Acute Lymphoid Leukemia 12

Classifications:

MalaCards categories:
Global: Cancer diseases Rare diseases
Anatomical: Blood diseases Immune diseases Bone diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:5604
NCIt 51 C4967
UMLS 74 C0751606
Sources

Summaries for Adult Acute Lymphocytic Leukemia

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MalaCards based summary : Adult Acute Lymphocytic Leukemia, also known as adult acute lymphoid leukemia, is related to acute lymphocytic leukemia and b-cell adult acute lymphocytic leukemia. An important gene associated with Adult Acute Lymphocytic Leukemia is SHMT1 (Serine Hydroxymethyltransferase 1), and among its related pathways/superpathways are Selenium Micronutrient Network and Carbon metabolism. The drugs Cyclophosphamide and Etoposide have been mentioned in the context of this disorder. Affiliated tissues include Blood and Blood, and related phenotype is homeostasis/metabolism.

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Related Diseases for Adult Acute Lymphocytic Leukemia

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Diseases in the Lymphocytic Leukemia family:

Leukemia, Chronic Lymphocytic 2 Leukemia, Chronic Lymphocytic
Leukemia, Chronic Lymphocytic 1 Leukemia, Chronic Lymphocytic 3
Leukemia, Chronic Lymphocytic 4 Leukemia, Chronic Lymphocytic 5
Acute Lymphocytic Leukemia Adult Acute Lymphocytic Leukemia

Diseases related to Adult Acute Lymphocytic Leukemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 36)
# Related Disease Score Top Affiliating Genes
1 acute lymphocytic leukemia 30.8 CDKN2B CSF3 MTHFR TYMS
2 b-cell adult acute lymphocytic leukemia 12.5
3 t-cell adult acute lymphocytic leukemia 12.5
4 leukemia 10.7
5 lymphocytic leukemia 10.7
6 hemifacial spasm 10.3 MTHFR TYMS
7 lymphoid leukemia 10.2
8 homocystinuria due to deficiency of n -methylenetetrahydrofolate reductase activity 10.2 MTHFR MTR
9 bile reflux 10.2 CDX1 CDX2
10 vitamin metabolic disorder 10.2 MTHFR MTR
11 gastric cardia carcinoma 10.2 MTHFR TYMS
12 cardia cancer 10.2 MTHFR TYMS
13 neural tube defects, folate-sensitive 10.2 MTHFR MTR
14 placental choriocarcinoma 10.1 ABCG2 MTR
15 macroglossia 10.1 CDKN1C CSF3
16 vitamin b12 deficiency 10.1 MTHFR MTR
17 ewing's family of tumors 10.1 CDKN2B CSF3
18 transcobalamin ii deficiency 10.0 MTHFR MTR
19 hematopoietic stem cell transplantation 10.0
20 core binding factor acute myeloid leukemia 10.0 ABCG2 CSF3
21 intestinal benign neoplasm 9.9 CDX2 MTHFR
22 adult lymphoma 9.9 CD2 CSF3
23 neural tube defects 9.9 MTHFR MTR SHMT1 TYMS
24 mucositis 9.9 CSF3 MTHFR TYMS
25 leukemia, acute lymphoblastic 9.9
26 amino acid metabolic disorder 9.9 MTHFR MTR
27 breast cancer 9.8
28 neurofibromatosis, type i 9.8
29 lymphoma, hodgkin, classic 9.8
30 lymphoma, non-hodgkin, familial 9.8
31 severe combined immunodeficiency 9.8
32 lymphoma 9.8
33 combined t cell and b cell immunodeficiency 9.8
34 large intestine cancer 9.7 ABCG2 CDX1 CDX2 MTHFR TYMS
35 hematologic cancer 9.5 ABCG2 CD2 CDKN1C CDKN2B CSF3
36 leukemia, acute myeloid 9.3 ABCG2 CD2 CDKN2B CDX4 CSF3

Graphical network of the top 20 diseases related to Adult Acute Lymphocytic Leukemia:



Diseases related to Adult Acute Lymphocytic Leukemia
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Symptoms & Phenotypes for Adult Acute Lymphocytic Leukemia

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MGI Mouse Phenotypes related to Adult Acute Lymphocytic Leukemia:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.28 ABCG2 CCR6 CDKN2B CDX2 CDX4 MTHFR
Sources

Drugs & Therapeutics for Adult Acute Lymphocytic Leukemia

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Drugs for Adult Acute Lymphocytic Leukemia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 418)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cyclophosphamide Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 50-18-0, 6055-19-2 2907
2
Etoposide Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 33419-42-0 36462
3
Idarubicin Approved Phase 4,Phase 3,Phase 2,Phase 1 58957-92-9 42890
4
leucovorin Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 58-05-9 143 6006
5
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 50-02-2 5743
6
Cladribine Approved, Investigational Phase 4,Phase 2,Phase 1,Not Applicable 4291-63-8 20279
7
Daunorubicin Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 20830-81-3 30323
8
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 1177-87-3
9
Cytarabine Approved, Experimental, Investigational Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1 147-94-4, 65-46-3 6253
10
Doxorubicin Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 23214-92-8 31703
11
Thioguanine Approved Phase 4,Phase 3,Phase 2,Not Applicable 154-42-7 2723601
12
Methylprednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 83-43-2 6741
13
Fludarabine Approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 75607-67-9, 21679-14-1 30751
14
Methylprednisolone hemisuccinate Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 2921-57-5
15
Vindesine Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 53643-48-4, 59917-39-4 40839
16
Methotrexate Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 1959-05-2, 59-05-2 126941
17
Teniposide Approved Phase 4,Phase 2 29767-20-2 34698
18
Mercaptopurine Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 50-44-2 667490
19
Prednisolone phosphate Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 302-25-0
20
Prednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 50-24-8 5755
21
Vincristine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 2068-78-2, 57-22-7 5978
22
Lenograstim Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 135968-09-1
23
rituximab Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 174722-31-7 10201696
24
Sargramostim Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 123774-72-1, 83869-56-1
25
Prednisone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 53-03-2 5865
26
Ifosfamide Approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 3778-73-2 3690
27
Mitoxantrone Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 65271-80-9 4212
28
Hydrocortisone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 50-23-7 5754
29
Hydrocortisone acetate Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 50-03-3
30
Thiotepa Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 52-24-4 5453
31
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 59-30-3 6037
32
Doxil Approved June 1999 Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 31703
33
Prednisolone hemisuccinate Experimental Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 2920-86-7
34 Anti-Bacterial Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
35 Etoposide phosphate Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
36 Topoisomerase Inhibitors Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
37 Antibiotics, Antitubercular Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
38 Antineoplastic Agents, Phytogenic Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
39 Antirheumatic Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
40 Folic Acid Antagonists Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
41 Gastrointestinal Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
42 glucocorticoids Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
43 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
44 Dermatologic Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
45 Alkylating Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
46 Antimitotic Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
47 Nucleic Acid Synthesis Inhibitors Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
48 Antimetabolites, Antineoplastic Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
49 Antineoplastic Agents, Hormonal Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
50 Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

Interventional clinical trials:

(show top 50) (show all 583)
# Name Status NCT ID Phase Drugs
1 HD-Idarubicin/Etoposide Intensified Conditioning Regimen Allo-HSCT for Adult ALL Unknown status NCT01873807 Phase 4 IDA;CTX;VP-16
2 German Multicenter Trial for Treatment of Newly Diagnosed Acute Lymphoblastic Leukemia in Adults (07/2003) Unknown status NCT00198991 Phase 4 Cyclophosphamide;Dexamethasone;Vincristine;daunorubicin;Asparaginase;Methotrexate;Cytarabine;Mercaptopurine;G-CSF;Vindesine;VP16;Prednisolone;Adriamycin;Thioguanine;VM26;Idarubicin;Fludarabine;Cladribine
3 German Multicenter Trial for Treatment of Elderly Patients With Newly Diagnosed Acute Lymphoblastic Leukemia Unknown status NCT00198978 Phase 4 Cyclophosphamide;Dexamethasone / Prednisolone;Cytarabine;Idarubicin;Granulocyte-Colony-Stimulating Factor;Mercaptopurine;Methotrexate;Rituximab;HDARAC;Vincristine;Depocyte;Asparaginase
4 Rituximab Plus Chemotherapy for CD20+ Adult Acute Lymphoblastic Leukemia Completed NCT01358253 Phase 4 Cyclophosphamide;Doxorubicin;Vincristine;Dexamethasone;Cytarabine;Methotrexate;Rituximab;6-Mercaptopurine;Prednisone;L-asparaginase
5 Treatment of Elderly Patients (>65 Years) With Acute Lymphoblastic Leukemia Completed NCT00199095 Phase 4 Adriamycin;Cyclophosphamide;Cytarabine;Dexamethasone;Idarubicin;Ifosfamide;Methotrexate;Mercaptopurine;VM26;Vincristine
6 German Multicenter Trial for Treatment of Newly Diagnosed Acute Lymphoblastic Leukemia in Adults (05/93) Completed NCT00199069 Phase 4 Asparaginase;Vincristine;Daunorubicin, Adriamycin;Cyclophosphamide;Ifosfamide;Cytarabine;Mitoxantrone;Methotrexate;6-Mercaptopurine;6-Thioguanine;VM26;Dexamethasone / Prednisolone
7 German Multicenter Trial for Treatment of Newly Diagnosed Acute Lymphoblastic Leukemia in Adults (06/99) Completed NCT00199056 Phase 4 Dexamethasone / Prednisolone;Cyclophosphamide;Methotrexate;Vincristine / Vindesine;Daunorubicin;Asparaginase;G-CSF;Cytarabine;6-Mercaptopurine;VP16;Adriamycin;Thioguanine;VM26;Idarubicin;Fludarabine;Ifosfamide
8 Trial for Treatment of Adult Patients With Standard Risk Acute Lymphoblastic Leukemia With Chemotherapy and Rituximab Completed NCT00199004 Phase 4 Cyclophosphamide;Dexamethasone / Prednisolone;Vincristine;Daunorubicin;Asparaginase;Methotrexate;Cytarabine;Mercaptopurine;G-CSF;Vindesine;VP16;Adriamycin;Thioguanine;VM26;Rituximab
9 Bone Marrow Transplantation in Treating Patients With Hematologic Cancer Completed NCT00003398 Phase 4 cyclophosphamide;thiotepa
10 Treatment of High Risk Adult Acute Lymphoblastic Leukemia Active, not recruiting NCT00853008 Phase 4 Vincristine;Daunorubicin;Prednisone;Mitoxantrone;Cytosine Arabinoside;Dexamethasone;Methotrexate (MTX);Cytarabine;ASP;Mercaptopurine;Teniposide;Hydrocortisone
11 Phase III Study of Vincristine Sulfate Liposome For Injection In Adults With Naïve Acute Lymphoblastic Leukemia Unknown status NCT02072785 Phase 3 Vincristine Sulfate Liposome;Vincristine Sulfate
12 Haplo-identical HSCT Versus Chemotherapy for Adult Acute Lymphoblastic Leukemia Patients Unknown status NCT02042690 Phase 3 Chemotherapy
13 Treatment of Acute Lymphoblastic Leukemia or Aggressive Lymphoma With Relapse in Central Nervous System With Depocyt Unknown status NCT00199108 Phase 2, Phase 3 Depocyt;Dexamethasone
14 High-Dose Methotrexate (MTX) for Adult Acute Lymphoblastic Leukemia (ALL) Unknown status NCT00131027 Phase 3 Cyclophosphamide;Daunorubicin;Vincristine;Prednisolone;L-asparaginase;Cytarabine;Etoposide;Dexamethasone;Methotrexate;Mercaptopurine;Doxorubicin;Methotrexate
15 Pegylated Liposomal Doxorubicin Versus Daunorubicin to Treat Acute Lymphoblastic Leukemia: Unknown status NCT02070523 Phase 3 VDCLD regimen
16 Ketamine Hydrochloride and Best Pain Management in Treating Cancer Patients With Neuropathic Pain Unknown status NCT01316744 Phase 3 ketamine hydrochloride
17 Combination Chemotherapy With or Without Idarubicin and Peripheral Stem Cell Transplantation in Treating Patients With Leukemia or Myelodysplastic Syndrome Unknown status NCT00002989 Phase 3 busulfan;cyclophosphamide;idarubicin;melphalan
18 Levofloxacin Compared With Cefepime in Treating Cancer Patients With Fever and Neutropenia Unknown status NCT00020865 Phase 3 cefepime hydrochloride;levofloxacin
19 Intensified Conditioning Regimen With High-Dose-Etoposide for Allo-HSCT for Adult Acute Lymphoblastic Leukemia Completed NCT01457040 Phase 2, Phase 3 TBI+CY+VP-16;FA+TBI+CY+VP-16
20 Intrathecal DepoCyte and Lineage-targeted Minimal Residual Disease-oriented Therapy of Acute Lymphoblastic Leukemia Completed NCT00795756 Phase 2, Phase 3 liposome-encapsulated cytarabine (DepoCyte);Triple intrathecal therapy (TIT)
21 Treatment of Hyperuricemia With Rasburicase in Patients With Acute Lymphoblastic Leukemia or High Grade Lymphoma Completed NCT00199043 Phase 3 Allopurinol;Rasburicase
22 Treatment of Acute Lymphoblastic Leukemia (ALL) in Younger Adults Completed NCT00327678 Phase 3 Rituximab;Imatinib Mesylate
23 Chemotherapy With or Without Bone Marrow Transplantation in Treating Patients With Acute Lymphoblastic Leukemia Completed NCT00002700 Phase 3 asparaginase;cyclophosphamide;cytarabine;daunorubicin hydrochloride;dexamethasone;doxorubicin hydrochloride;leucovorin calcium;mercaptopurine;methotrexate;mitoxantrone hydrochloride;prednisolone;prednisone;therapeutic hydrocortisone;vincristine sulfate
24 Low-Dose Prednisone or Methylprednisolone in Treating Patients With Newly Diagnosed Acute Graft-versus-Host Disease Completed NCT00929695 Phase 3 prednisone;methylprednisolone
25 Stem Cell Transplantation Compared With Standard Chemotherapy in Treating Patients With Acute Lymphoblastic Leukemia in First Remission Completed NCT00002514 Phase 3 asparaginase;cyclophosphamide;cytarabine;daunorubicin hydrochloride;dexamethasone;etoposide;imatinib mesylate;leucovorin calcium;mercaptopurine;methotrexate;prednisone;thioguanine;vincristine sulfate
26 Eculizumab in Treating Patients With Paroxysmal Nocturnal Hemoglobinuria Completed NCT00112983 Phase 3
27 Study of US-ATG-F to Prevent Chronic Graft Versus Host Disease (GVHD) Completed NCT01295710 Phase 3
28 Dasatinib and Combination Chemotherapy in Treating Young Patients With Newly Diagnosed Acute Lymphoblastic Leukemia Completed NCT00720109 Phase 2, Phase 3 Asparaginase;Cyclophosphamide;Cytarabine;Dasatinib;Daunorubicin Hydrochloride;Dexamethasone;Etoposide;Hydrocortisone Sodium Succinate;Ifosfamide;Leucovorin Calcium;Mercaptopurine;Methotrexate;Methylprednisolone;Pegaspargase;Prednisone;Vincristine Sulfate
29 Dexamethasone Compared With Prednisone During Induction Therapy and MTX With or Without Leucovorin During Maintenance Therapy in Treating Patients With Newly Diagnosed High-Risk Acute Lymphoblastic Leukemia Completed NCT00075725 Phase 3 cyclophosphamide;cytarabine;daunorubicin hydrochloride;dexamethasone;doxorubicin hydrochloride;leucovorin calcium;mercaptopurine;methotrexate;pegaspargase;prednisone;thioguanine;vincristine sulfate
30 Internet-Based Program With or Without Telephone-Based Problem-Solving Training in Helping Long-Term Survivors of Hematopoietic Stem Cell Transplant Cope With Late Complications Completed NCT00799461 Phase 3
31 Comparison of Two Combination Chemotherapy Regimens in Treating Adults With Previously Untreated Leukemia or Lymphoma Completed NCT00002766 Phase 3 carmustine;cyclophosphamide;cytarabine;daunorubicin hydrochloride;doxorubicin hydrochloride;etoposide;mercaptopurine;methotrexate;mitoxantrone hydrochloride;pegaspargase;prednisone;vincristine sulfate
32 Personalized Information or Basic Information in Helping Patients Make Decisions About Participating in a Clinical Trial Completed NCT00750009 Phase 3
33 American Ginseng in Treating Patients With Fatigue Caused by Cancer Completed NCT00719563 Phase 3 American ginseng
34 Darbepoetin Alfa With or Without Iron in Treating Anemia Caused By Chemotherapy in Patients With Cancer Completed NCT00661999 Phase 3 sodium ferric gluconate complex in sucrose
35 Fentanyl Sublingual Spray in Treating Patients With Breakthrough Cancer Pain Completed NCT00538850 Phase 3 Fentanyl sublingual spray;Placebo
36 Bone Marrow Transplantation in Treating Patients With Leukemia, Myelodysplasia, or Lymphoblastic Lymphoma Completed NCT00003187 Phase 2, Phase 3 cyclophosphamide;cyclosporine;cytarabine;methotrexate;methylprednisolone
37 St. John's Wort in Relieving Fatigue in Patients Undergoing Chemotherapy or Hormone Therapy for Cancer Completed NCT00005805 Phase 3
38 Dalteparin to Prevent Complications in Cancer Patients Receiving Chemotherapy Through a Catheter Completed NCT00006083 Phase 3 Fragmin
39 Valacyclovir in Preventing Cytomegalovirus Infection in Patients Who Are Undergoing Donor Stem Cell Transplantation Completed NCT00045292 Phase 3 acyclovir;acyclovir sodium;valacyclovir
40 Treatment for Chronic Pain in Patients With Advanced Cancer Completed NCT00003687 Phase 3 dextromethorphan hydrobromide;morphine sulfate
41 Opioid Titration Order Sheet or Standard Care in Treating Patients With Cancer Pain Completed NCT00666211 Phase 3
42 Bone Marrow Transplantation in Treating Patients With Acute Leukemia in First or Second Remission Completed NCT00002534 Phase 3 cyclophosphamide;cytarabine;methylprednisolone;thiotepa
43 Treatment of Bone Marrow to Prevent Graft-Versus-Host Disease in Patients With Acute or Chronic Leukemia Undergoing Bone Marrow Transplantation Completed NCT00004255 Phase 2, Phase 3 cyclophosphamide;fludarabine phosphate;methylprednisolone;tacrolimus
44 Music Therapy or Book Discussion in Improving Quality of Life in Young Patients Undergoing Stem Cell Transplant Completed NCT00305851 Phase 3
45 Laboratory-Treated Donor Bone Marrow in Treating Patients Who Are Undergoing a Donor Bone Marrow Transplant for Hematologic Cancer Completed NCT00265837 Phase 3
46 Ondansetron in Treating Patients With Advanced Cancer and Chronic Nausea and Vomiting Not Caused by Cancer Treatment Completed NCT00006348 Phase 3 ondansetron
47 Prevention of Infection in Patients With Hematologic Cancer and Persistent Fever Caused by a Low White Blood Cell Count Completed NCT00003805 Phase 3 piperacillin sodium;piperacillin-tazobactam;tazobactam sodium;vancomycin
48 Caspofungin Acetate Compared With Amphotericin B Liposomal in Treating Patients With Persistent Fever and Neutropenia Following Cancer Treatment Completed NCT00008359 Phase 3 caspofungin acetate;liposomal amphotericin B
49 Liposomal Amphotericin B in Treating Granulocytopenia and Persistent Unexplained Fever in Cancer Patients Completed NCT00003938 Phase 3 liposomal amphotericin B
50 Combination Chemotherapy in Treating Patients With Non-Hodgkin's Lymphoma or Acute Lymphocytic Leukemia Completed NCT00005977 Phase 3 cyclophosphamide;cytarabine;dexamethasone;doxorubicin hydrochloride;etoposide;ifosfamide;leucovorin calcium;methotrexate;vincristine sulfate

Search NIH Clinical Center for Adult Acute Lymphocytic Leukemia

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Adult Acute Lymphocytic Leukemia cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Adult Acute Lymphocytic Leukemia:
Hematopoietic stem cells for treatment of hematologic malignancies
Peripheral blood stem cells for treatment of hematologic malignancies
Embryonic/Adult Cultured Cells Related to Adult Acute Lymphocytic Leukemia:
Bone marrow-derived hematopoietic stem cells
Peripheral blood-derived hematopoietic stem cells (family)
Sources

Genetic Tests for Adult Acute Lymphocytic Leukemia

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Anatomical Context for Adult Acute Lymphocytic Leukemia

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MalaCards organs/tissues related to Adult Acute Lymphocytic Leukemia:

42
Bone, Bone Marrow, Myeloid, T Cells, B Cells, Kidney, Breast
LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database

Cells/anatomical compartments in embryo or adult related to Adult Acute Lymphocytic Leukemia:
# Tissue Anatomical CompartmentCell Relevance
1 Blood Hematopoietic Bone Marrow Hematopoietic Stem Cells Potential therapeutic candidate
2 Blood Peripheral Blood Mature B-Cells Affected by disease
3 Blood Hematopoietic Bone Marrow Small Pre B-Cells Affected by disease
Sources

Publications for Adult Acute Lymphocytic Leukemia

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Articles related to Adult Acute Lymphocytic Leukemia:

(show top 50) (show all 72)
# Title Authors Year
1
Efficacy and Safety of Vincristine Sulfate Liposome Injection in the Treatment of Adult Acute Lymphocytic Leukemia. ( 27328933 )
2016
2
Clofarabine for the treatment of adult acute lymphoid leukemia: the Group for Research on Adult Acute Lymphoblastic Leukemia intergroup. ( 24996442 )
2015
3
The Effect of GVHD on Long-term Outcomes after Peripheral Blood Allogeneic Stem Cell Transplantation from an HLA-identical Sibling in Adult Acute Lymphocytic Leukemia: A Landmark Analysis Approach in Competing Risks. ( 24800032 )
2014
4
Medical history, lifestyle, family history, and occupational risk factors for adult acute lymphocytic leukemia: the InterLymph Non-Hodgkin Lymphoma Subtypes Project. ( 25174033 )
2014
5
Serum peptidome based biomarkers searching for monitoring minimal residual disease in adult acute lymphocytic leukemia. ( 25317080 )
2014
6
Surface antigens analysis reveals significant expression of candidate targets for immunotherapy in adult acute lymphoid leukemia. ( 21077738 )
2011
7
[Expression and clinical significance of caudal type homeobox transcription factor-2 in adult acute lymphocytic leukemia]. ( 21518475 )
2011
8
Novel targets for treatment of adult acute lymphocytic leukemia. ( 20680526 )
2010
9
Allogeneic hematopoietic stem cell transplantation for adult acute lymphocytic leukemia. ( 20425427 )
2009
10
Allogeneic hematopoietic stem cell transplantation in adult acute lymphocytic leukemia: impact of donor source on survival. ( 19041062 )
2008
11
Long-term molecular complete remission with IFN-alpha in Ph+ adult acute lymphoid leukemia patients. ( 18273047 )
2008
12
[Gene expression of breast cancer resistance protein in adult acute lymphocytic leukemia and its clinical significance]. ( 18315895 )
2008
13
Phase II study of sphingosomal vincristine in patients with recurrent or refractory adult acute lymphocytic leukemia. ( 16331634 )
2006
14
Protein expression of a triad of frequently methylated genes, p73, p57Kip2, and p15, has prognostic value in adult acute lymphocytic leukemia independently of its methylation status. ( 15851765 )
2005
15
Gene expression profiles of B-lineage adult acute lymphocytic leukemia reveal genetic patterns that identify lineage derivation and distinct mechanisms of transformation. ( 16243790 )
2005
16
Long-term follow-up results of hyperfractionated cyclophosphamide, vincristine, doxorubicin, and dexamethasone (Hyper-CVAD), a dose-intensive regimen, in adult acute lymphocytic leukemia. ( 15481055 )
2004
17
Aberrant DNA methylation of p57KIP2 identifies a cell-cycle regulatory pathway with prognostic impact in adult acute lymphocytic leukemia. ( 12586619 )
2003
18
Treatment outcome of adult acute lymphocytic leukemia with VPD(L) regimen: analysis of prognostic factors. ( 12760264 )
2003
19
Polymorphisms in the thymidylate synthase and serine hydroxymethyltransferase genes and risk of adult acute lymphocytic leukemia. ( 11986237 )
2002
20
DNA methylation patterns at relapse in adult acute lymphocytic leukemia. ( 12060634 )
2002
21
DNA methylation of multiple promoter-associated CpG islands in adult acute lymphocytic leukemia. ( 12114423 )
2002
22
Induction therapy of adult acute lymphocytic leukemia without the use of vincristine or prednisone. ( 11253603 )
2001
23
Central nervous system involvement in adult acute lymphocytic leukemia. ( 11253605 )
2001
24
Adult acute lymphocytic leukemia. Future research directions. ( 11253607 )
2001
25
High-dose anthracycline induction in adult acute lymphocytic leukemia. ( 11253610 )
2001
26
Rare adult acute lymphocytic leukemia with CD56 expression in the ECOG experience shows unexpected phenotypic and genotypic heterogeneity. ( 11279625 )
2001
27
Cytogenetic aberrations in adult acute lymphocytic leukemia: optimal technique may influence the results. ( 11454422 )
2001
28
Results of treatment with hyper-CVAD, a dose-intensive regimen, in adult acute lymphocytic leukemia. ( 10653870 )
2000
29
Adult acute lymphocytic leukemia. Introduction and questions related to current programs. ( 11147219 )
2000
30
Cytogenetics in adult acute lymphocytic leukemia. ( 11147221 )
2000
31
Immunophenotypes in adult acute lymphocytic leukemia. Role of flow cytometry in diagnosis and monitoring of disease. ( 11147222 )
2000
32
Insights into the biologic and molecular abnormalities in adult acute lymphocytic leukemia. ( 11147223 )
2000
33
The Medical Research Council trials in adult acute lymphocytic leukemia. ( 11147226 )
2000
34
Adult acute lymphocytic leukemia study testing chemotherapy and autologous and allogeneic transplantation. A follow-up report of the French protocol LALA 87. ( 11147227 )
2000
35
The hyper-CVAD regimen in adult acute lymphocytic leukemia. ( 11147229 )
2000
36
Familial neurofibromatosis type I and adult acute lymphocytic leukemia. ( 10329933 )
1999
37
Deletions and losses in chromosomes 5 or 7 in adult acute lymphocytic leukemia: incidence, associations and implications. ( 10360374 )
1999
38
Analysis of the BCR-ABL protein in Philadelphia chromosome-positive adult acute lymphocytic leukemia. ( 9305617 )
1997
39
Avascular necrosis of bone after adult acute lymphocytic leukemia treatment with methotrexate, vincristine, L-asparaginase, and dexamethasone (MOAD). ( 8756084 )
1996
40
Growth and biologic properties of karyotypically defined subcategories of adult acute lymphocytic leukemia in mice with severe combined immunodeficiency. ( 7492788 )
1995
41
Myeloid markers in adult acute lymphocytic leukemia. Correlations with patient and disease characteristics and with prognosis. ( 8635059 )
1995
42
Philadelphia-chromosome-positive adult acute lymphocytic leukemia: characteristics, treatment results, and prognosis in 41 patients. ( 8030658 )
1994
43
Adult acute lymphocytic leukemia: critical review of current knowledge. ( 8059784 )
1994
44
Serum beta 2-microglobulin in adult acute lymphocytic leukemia. ( 8166167 )
1994
45
Management of adult acute lymphocytic leukemia: present issues and key challenges. ( 8201394 )
1994
46
Late intensification therapy in adult acute lymphoid leukemia: long-term follow-up of the Southeastern Cancer Study Group experience. ( 7858504 )
1994
47
The role of bone marrow transplantation in adult acute lymphocytic leukemia. ( 8338797 )
1993
48
Long-term follow-up of treatment and potential cure of adult acute lymphocytic leukemia with MOAD: a non-anthracycline containing regimen. ( 8350624 )
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49
Prognostic significance of elevated serum beta 2-microglobulin levels in adult acute lymphocytic leukemia. ( 1466355 )
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50
Adult acute lymphocytic leukemia: the Eastern Cooperative Oncology Group experience. ( 1578927 )
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Sources

Variations for Adult Acute Lymphocytic Leukemia

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Sources

Expression for Adult Acute Lymphocytic Leukemia

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Search GEO for disease gene expression data for Adult Acute Lymphocytic Leukemia.
Sources

Pathways for Adult Acute Lymphocytic Leukemia

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Pathways related to Adult Acute Lymphocytic Leukemia according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Selenium Micronutrient Network 1
Show member pathways
 11.83 MTHFR MTR SHMT1
2
Carbon metabolism 38
Show member pathways
 11.76 MTHFR MTR SHMT1
3
Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers 66
11.46 CDX1 CDX2 CDX4
4
One carbon pool by folate 38
Show member pathways
 11.41 MTHFR MTR SHMT1 TYMS
5
Antifolate resistance 38
10.42 ABCG2 MTHFR SHMT1 TYMS
Sources

GO Terms for Adult Acute Lymphocytic Leukemia

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Biological processes related to Adult Acute Lymphocytic Leukemia according to GeneCards Suite gene sharing:

(show all 18)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription by RNA polymerase II GO:0045944 9.97 CDKN2B CDX1 CDX4 CSF3 TP73
2 response to drug GO:0042493 9.76 ABCG2 MTHFR TP73 TYMS
3 cell cycle arrest GO:0007050 9.7 CDKN1C CDKN2B TP73
4 anterior/posterior pattern specification GO:0009952 9.65 CDX1 CDX2 CDX4
5 regulation of mitotic cell cycle GO:0007346 9.57 CDKN1C TP73
6 protein tetramerization GO:0051262 9.56 SHMT1 TP73
7 positive regulation of transforming growth factor beta receptor signaling pathway GO:0030511 9.55 CDKN1C CDKN2B
8 one-carbon metabolic process GO:0006730 9.54 MTHFR SHMT1
9 folic acid metabolic process GO:0046655 9.51 MTHFR SHMT1
10 negative regulation of phosphorylation GO:0042326 9.49 CDKN1C CDKN2B
11 methionine biosynthetic process GO:0009086 9.43 MTHFR MTR
12 labyrinthine layer development GO:0060711 9.4 CDX2 CDX4
13 response to folic acid GO:0051593 9.37 MTHFR TYMS
14 placenta development GO:0001890 9.33 CDKN1C CDX2 CDX4
15 regulation of somitogenesis GO:0014807 9.32 CDX1 CDX2
16 dTMP biosynthetic process GO:0006231 9.26 SHMT1 TYMS
17 tetrahydrofolate interconversion GO:0035999 9.13 MTHFR SHMT1 TYMS
18 tetrahydrofolate metabolic process GO:0046653 8.8 MTHFR SHMT1 TYMS

Molecular functions related to Adult Acute Lymphocytic Leukemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 methyl-CpG binding GO:0008327 9.16 CDX1 CDX2
2 translation repressor activity, mRNA regulatory element binding GO:0000900 8.96 SHMT1 TYMS
3 cyclin-dependent protein serine/threonine kinase inhibitor activity GO:0004861 8.62 CDKN1C CDKN2B
Sources

Sources for Adult Acute Lymphocytic Leukemia

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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