MCID: ADL080
MIFTS: 24

Adult Acute Respiratory Distress Syndrome

Categories: Blood diseases, Cardiovascular diseases, Rare diseases, Respiratory diseases

Aliases & Classifications for Adult Acute Respiratory Distress Syndrome

MalaCards integrated aliases for Adult Acute Respiratory Distress Syndrome:

Name: Adult Acute Respiratory Distress Syndrome 59
Adult Ards 59

Characteristics:

Orphanet epidemiological data:

59
adult acute respiratory distress syndrome
Inheritance: Not applicable; Prevalence: 1-5/10000 (Europe); Age of onset: Adult;

Classifications:

Orphanet: 59  
Rare respiratory diseases


External Ids:

ICD10 via Orphanet 34 J80
Orphanet 59 ORPHA70578

Summaries for Adult Acute Respiratory Distress Syndrome

MalaCards based summary : Adult Acute Respiratory Distress Syndrome, also known as adult ards, is related to acute respiratory distress syndrome and respiratory failure. The drugs Prednisolone phosphate and Methylprednisolone have been mentioned in the context of this disorder. Affiliated tissues include lung and endothelial, and related phenotypes are hypotension and dyspnea

Related Diseases for Adult Acute Respiratory Distress Syndrome

Diseases in the Adult Respiratory Distress Syndrome family:

Acute Respiratory Distress Syndrome Adult Acute Respiratory Distress Syndrome

Diseases related to Adult Acute Respiratory Distress Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 acute respiratory distress syndrome 12.0
2 respiratory failure 10.1
3 pneumothorax 9.9
4 pneumonia 9.9
5 adult respiratory distress syndrome 9.8

Graphical network of the top 20 diseases related to Adult Acute Respiratory Distress Syndrome:



Diseases related to Adult Acute Respiratory Distress Syndrome

Symptoms & Phenotypes for Adult Acute Respiratory Distress Syndrome

Human phenotypes related to Adult Acute Respiratory Distress Syndrome:

59 (show all 17)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 hypotension 59 Frequent (79-30%)
2 dyspnea 59 Very frequent (99-80%)
3 pulmonary infiltrates 59 Very frequent (99-80%)
4 pancreatitis 59 Very rare (<4-1%)
5 respiratory failure 59 Frequent (79-30%)
6 hypoxemia 59 Very frequent (99-80%)
7 sepsis 59 Frequent (79-30%)
8 vasculitis 59 Very rare (<4-1%)
9 pneumonia 59 Occasional (29-5%)
10 metabolic acidosis 59 Frequent (79-30%)
11 diabetic ketoacidosis 59 Very rare (<4-1%)
12 pulmonary edema 59 Frequent (79-30%)
13 abnormal serum interleukin level 59 Very frequent (99-80%)
14 increased serum interleukin-6 59 Frequent (79-30%)
15 abnormal blood gas level 59 Very frequent (99-80%)
16 abnormality of tumor necrosis factor secretion 59 Frequent (79-30%)
17 shock 59 Frequent (79-30%)

Drugs & Therapeutics for Adult Acute Respiratory Distress Syndrome

Drugs for Adult Acute Respiratory Distress Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 30)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Prednisolone phosphate Approved, Vet_approved Phase 3 302-25-0
2
Methylprednisolone Approved, Vet_approved Phase 3 83-43-2 6741
3
Methylprednisolone hemisuccinate Approved Phase 3 2921-57-5
4
Ketoconazole Approved, Investigational Phase 3 65277-42-1 47576
5
Miconazole Approved, Investigational, Vet_approved Phase 3 22916-47-8 4189
6
Prednisolone Approved, Vet_approved Phase 3 50-24-8 5755
7
Prednisolone hemisuccinate Experimental Phase 3 2920-86-7
8 14-alpha Demethylase Inhibitors Phase 3
9 Antiemetics Phase 3
10 Hormones Phase 3
11 Steroid Synthesis Inhibitors Phase 3
12 Prednisolone acetate Phase 3
13 Neuroprotective Agents Phase 3
14 Cytochrome P-450 CYP3A Inhibitors Phase 3
15 glucocorticoids Phase 3
16 Methylprednisolone Acetate Phase 3
17 Anti-Inflammatory Agents Phase 3
18 Gastrointestinal Agents Phase 3
19 Protective Agents Phase 3
20 Hormone Antagonists Phase 3
21 Peripheral Nervous System Agents Phase 3
22 Anti-Infective Agents Phase 3
23 Cytochrome P-450 Enzyme Inhibitors Phase 3
24 Antineoplastic Agents, Hormonal Phase 3
25 Antifungal Agents Phase 3
26 Autonomic Agents Phase 3
27 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3
28 Pharmaceutical Solutions Phase 2
29 Respiratory System Agents Phase 2
30 Pulmonary Surfactants Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Acute Respiratory Distress Syndrome Clinical Network (ARDSNet) Completed NCT00000579 Phase 3 Lysofylline;Methylprednisolone;Ketoconazole
2 A Phase IIa, Placebo Controlled, Multicenter Pilot Study to Evaluate the Safety and Efficacy of BIO-11006 Inhalation Solution in Patients With Acute Respiratory Distress Syndrome Recruiting NCT03202394 Phase 2 BIO-11006;Placebo
3 A Multicenter, Randomized, Controlled Trial Comparing the Safety and Effectiveness of SURFAXIN® (Lucinactant) Delivered Via Bronchopulmonary Segmental Lavage to Standard of Care in Patients With Acute Respiratory Distress Syndrome (ARDS). Terminated NCT00215553 Phase 2 A.1 Lucinactant;A.2 Lucinactant;A.3 Lucinactant;A.4 Lucinactant;B.1 Lucinactant;B.2 Lucinactant
4 Prone Positioning and Spontaneous Breathing: a Feasibility Study Not yet recruiting NCT03768154 Phase 1
5 The Role of Polymorphism in Prognosis of Acute Respiratory Distress Syndrome (ARDS)and Phenotype Patients to Guide Therapy Unknown status NCT02644798
6 Goal Directed Mechanical Ventilation Aimed at Optimal Lung Compliance Approach Guided by Esophageal Pressure in Acute Respiratory Failure. Unknown status NCT01668368
7 Effectiveness and Costs of Remote Monitoring for Clinical Trials Completed NCT01151995
8 The Effect of Intensive Care Unit Therapies and Mechanical Ventilation Strategy on Long Term Outcome in Pediatric ARDS A Follow-up of the Real-time Effort Driven VENTilator Management Study (REDvent) Recruiting NCT03709199
9 Pediatric Acute Respiratory Distress Syndrome: Determining Post-discharge Outcomes, the Effect of Early Diagnosis, and Identifying Inflammatory Signatures to Better Understand Disease Mechanism Not yet recruiting NCT03585582
10 Human Umbilical Cord Derived Mesenchymal Stem Cells Therapy in Acute Respiratory Distress Syndrome: a Pilot Study Not yet recruiting NCT03608592 Early Phase 1

Search NIH Clinical Center for Adult Acute Respiratory Distress Syndrome

Genetic Tests for Adult Acute Respiratory Distress Syndrome

Anatomical Context for Adult Acute Respiratory Distress Syndrome

MalaCards organs/tissues related to Adult Acute Respiratory Distress Syndrome:

41
Lung, Endothelial

Publications for Adult Acute Respiratory Distress Syndrome

Articles related to Adult Acute Respiratory Distress Syndrome:

(show top 50) (show all 77)
# Title Authors PMID Year
1
Novel Risk Factors for Posttraumatic Stress Disorder Symptoms in Family Members of Acute Respiratory Distress Syndrome Survivors. 38
30985448 2019
2
What links ventilator driving pressure with survival in the acute respiratory distress syndrome? A computational study. 38
30744629 2019
3
Effect of surfactant administration on outcomes of adult patients in acute respiratory distress syndrome: a meta-analysis of randomized controlled trials. 38
30626363 2019
4
Comparison of Hemodynamic Monitoring between Transesophageal Doppler and Ultrasonography-Guided Inferior Vena Cava Distensibility in Supine versus Prone Position: A Pilot Study. 38
30662221 2018
5
[Advances in the diagnosis and treatment of pediatric acute respiratory distress syndrome]. 38
30210022 2018
6
Advanced modes of mechanical ventilation and optimal targeting schemes. 38
30136011 2018
7
[Influence of enteral nutrition initiation timing on curative effect and prognosis of acute respiratory distress syndrome patients with mechanical ventilation]. 38
30009734 2018
8
A Comparative Analysis of Survival Prediction Using PRESERVE and RESP Scores. 38
28410641 2017
9
Venovenous Versus Venoarterial Extracorporeal Membrane Oxygenation for Adult Patients With Acute Respiratory Distress Syndrome Requiring Precannulation Hemodynamic Support: A Review of the ELSO Registry. 38
28190548 2017
10
Predicted body weight relationships for protective ventilation - unisex proposals from pre-term through to adult. 38
28535820 2017
11
Severe Pediatric Acute Respiratory Distress Syndrome Due to Scrub Typhus: Successful Ventilation with Airway Pressure Release Ventilation Mode after Becoming Refractory to Protective Ventilation. 38
28584437 2017
12
Serial Lactate Measurements as a Prognostic Tool in Venovenous Extracorporeal Membrane Oxygenation Support. 38
27666781 2017
13
Inhaled nitric oxide in adult patients with acute respiratory distress syndrome. 38
28236803 2017
14
Outcomes and survival prediction models for severe adult acute respiratory distress syndrome treated with extracorporeal membrane oxygenation. 38
27919283 2016
15
Associations between ventilator settings during extracorporeal membrane oxygenation for refractory hypoxemia and outcome in patients with acute respiratory distress syndrome: a pooled individual patient data analysis : Mechanical ventilation during ECMO. 38
27586996 2016
16
Mechanical Ventilation in Patients with the Acute Respiratory Distress Syndrome and Treated with Extracorporeal Membrane Oxygenation: Impact on Hospital and 30 Day Postdischarge Survival. 38
27347707 2016
17
Circulating markers of endothelial and alveolar epithelial dysfunction are associated with mortality in pediatric acute respiratory distress syndrome. 38
27101828 2016
18
High frequency oscillatory ventilation for adult ARDS: Is this the end of the road? 38
27660253 2016
19
BPD Following Preterm Birth: A Model for Chronic Lung Disease and a Substrate for ARDS in Childhood. 38
27379219 2016
20
Relevant Outcomes in Pediatric Acute Respiratory Distress Syndrome Studies. 38
27242980 2016
21
Controversies in the Management of Severe ARDS: Optimal Ventilator Management and Use of Rescue Therapies. 38
26595042 2015
22
Pulmonary specific ancillary treatment for pediatric acute respiratory distress syndrome: proceedings from the Pediatric Acute Lung Injury Consensus Conference. 38
26035366 2015
23
Pediatric acute respiratory distress syndrome: definition, incidence, and epidemiology: proceedings from the Pediatric Acute Lung Injury Consensus Conference. 38
26035358 2015
24
Extracorporeal membrane oxygenation for acute respiratory distress syndrome. 38
27408728 2015
25
Impact of Corticosteroids on Mortality in Patients with Acute Respiratory Distress Syndrome: A Systematic Review and Meta-analysis. 38
26267908 2015
26
Compliance versus dead space for optimum positive end expiratory pressure determination in acute respiratory distress syndrome. 38
25136189 2014
27
[High-frequency oscillatory ventilation in patients with acute respiratory distress syndrome: a meta-analysis]. 38
25327856 2014
28
D-dimers as an early marker for oxygenator exchange in extracorporeal membrane oxygenation. 38
24508200 2014
29
Influenza A (H1N1) vs non-H1N1 ARDS: analysis of clinical course. 38
24508203 2014
30
Efficacy and adverse events of high-frequency oscillatory ventilation in adult patients with acute respiratory distress syndrome: a meta-analysis. 38
24886674 2014
31
Is high-frequency oscillatory ventilation more effective and safer than conventional protective ventilation in adult acute respiratory distress syndrome patients? A meta-analysis of randomized controlled trials. 38
24887179 2014
32
The acute respiratory distress syndrome: incidence and mortality, has it changed? 38
24309954 2014
33
High-frequency oscillatory ventilation for early acute respiratory distress syndrome in adults. 38
24356284 2014
34
Early induction of uncoupling protein-2 in pulmonary macrophages in hyperoxia-associated lung injury. 38
23905971 2013
35
Neuromuscular blocking agents in acute respiratory distress syndrome: a systematic review and meta-analysis of randomized controlled trials. 38
23497608 2013
36
Critical care paper review 2012. 38
23101019 2012
37
The role of high-frequency oscillatory ventilation in the treatment of acute respiratory failure in adults. 38
22157255 2012
38
Increased extravascular lung water reduces the efficacy of alveolar recruitment maneuver in acute respiratory distress syndrome. 38
22649717 2012
39
Resolution of organ functional scores to predict the outcome in adult acute respiratory distress syndrome patients receiving high-frequency oscillatory ventilation. 38
22027886 2011
40
Extracorporeal membrane oxygenation in adult acute respiratory distress syndrome. 38
21742220 2011
41
[Interhospital transport of patients requiring extracorporeal membrane oxygenation ECMO]. 38
22011921 2011
42
A practical approach to adult acute respiratory distress syndrome. 38
21572751 2010
43
Genetic susceptibility in acute lung injury and acute respiratory distress syndrome. 38
25307334 2009
44
Angiotensin-converting enzyme D allele does not influence susceptibility to acute hypoxic respiratory failure in children. 38
18787808 2008
45
Angiotensin-converting enzyme genotype may predict survival following major trauma. 38
18955615 2008
46
Protective ventilation in ARDS: as soon as possible. An immediate use of HFOV. 38
18721463 2008
47
Acute respiratory distress syndrome: is it underrecognized in the pediatric intensive care unit? 38
18288473 2008
48
The initial response to inhaled nitric oxide treatment for intensive care unit patients with acute respiratory distress syndrome. 38
17396026 2008
49
A protocol for high-frequency oscillatory ventilation in adults: results from a roundtable discussion. 38
17522576 2007
50
Respiratory controversies in the critical care setting. Does high-frequency ventilation offer benefits over conventional ventilation in adult patients with acute respiratory distress syndrome? 38
17484791 2007

Variations for Adult Acute Respiratory Distress Syndrome

Expression for Adult Acute Respiratory Distress Syndrome

Search GEO for disease gene expression data for Adult Acute Respiratory Distress Syndrome.

Pathways for Adult Acute Respiratory Distress Syndrome

GO Terms for Adult Acute Respiratory Distress Syndrome

Sources for Adult Acute Respiratory Distress Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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