MCID: ADL080
MIFTS: 26

Adult Acute Respiratory Distress Syndrome

Categories: Blood diseases, Cardiovascular diseases, Rare diseases, Respiratory diseases

Aliases & Classifications for Adult Acute Respiratory Distress Syndrome

MalaCards integrated aliases for Adult Acute Respiratory Distress Syndrome:

Name: Adult Acute Respiratory Distress Syndrome 58
Adult Ards 58

Characteristics:

Orphanet epidemiological data:

58
adult acute respiratory distress syndrome
Inheritance: Not applicable; Prevalence: 1-5/10000 (Europe); Age of onset: Adult;

Classifications:

Orphanet: 58  
Rare respiratory diseases


External Ids:

ICD10 via Orphanet 33 J80
Orphanet 58 ORPHA70578

Summaries for Adult Acute Respiratory Distress Syndrome

MalaCards based summary : Adult Acute Respiratory Distress Syndrome, also known as adult ards, is related to respiratory failure and pneumothorax. The drugs Methylprednisolone and Ketoconazole have been mentioned in the context of this disorder. Affiliated tissues include lung and endothelial, and related phenotypes are dyspnea and pulmonary infiltrates

Related Diseases for Adult Acute Respiratory Distress Syndrome

Diseases in the Adult Respiratory Distress Syndrome family:

Adult Acute Respiratory Distress Syndrome

Diseases related to Adult Acute Respiratory Distress Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 respiratory failure 10.1
2 pneumothorax 9.9
3 viral pneumonia 9.8
4 adult respiratory distress syndrome 9.8

Symptoms & Phenotypes for Adult Acute Respiratory Distress Syndrome

Human phenotypes related to Adult Acute Respiratory Distress Syndrome:

58 31 (show all 17)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 dyspnea 58 31 hallmark (90%) Very frequent (99-80%) HP:0002094
2 pulmonary infiltrates 58 31 hallmark (90%) Very frequent (99-80%) HP:0002113
3 hypoxemia 58 31 hallmark (90%) Very frequent (99-80%) HP:0012418
4 sepsis 58 31 frequent (33%) Frequent (79-30%) HP:0100806
5 respiratory failure 58 31 frequent (33%) Frequent (79-30%) HP:0002878
6 metabolic acidosis 58 31 frequent (33%) Frequent (79-30%) HP:0001942
7 hypotension 58 31 frequent (33%) Frequent (79-30%) HP:0002615
8 pulmonary edema 58 31 frequent (33%) Frequent (79-30%) HP:0100598
9 abnormality of tumor necrosis factor secretion 58 31 frequent (33%) Frequent (79-30%) HP:0011118
10 increased serum interleukin-6 58 31 frequent (33%) Frequent (79-30%) HP:0030783
11 shock 58 31 frequent (33%) Frequent (79-30%) HP:0031273
12 pneumonia 58 31 occasional (7.5%) Occasional (29-5%) HP:0002090
13 vasculitis 58 31 very rare (1%) Very rare (<4-1%) HP:0002633
14 pancreatitis 58 31 very rare (1%) Very rare (<4-1%) HP:0001733
15 diabetic ketoacidosis 58 31 very rare (1%) Very rare (<4-1%) HP:0001953
16 abnormal serum interleukin level 58 Very frequent (99-80%)
17 abnormal blood gas level 58 Very frequent (99-80%)

Drugs & Therapeutics for Adult Acute Respiratory Distress Syndrome

Drugs for Adult Acute Respiratory Distress Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 40)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Methylprednisolone Approved, Vet_approved Phase 3 83-43-2 6741
2
Ketoconazole Approved, Investigational Phase 3 65277-42-1 47576
3
Prednisolone phosphate Approved, Vet_approved Phase 3 302-25-0
4
Methylprednisolone hemisuccinate Approved Phase 3 2921-57-5
5
Clotrimazole Approved, Vet_approved Phase 3 23593-75-1 2812
6
Prednisolone Approved, Vet_approved Phase 3 50-24-8 5755
7 Prednisolone acetate Approved, Vet_approved Phase 3 52-21-1
8
Miconazole Approved, Investigational, Vet_approved Phase 3 22916-47-8 4189
9
Folic acid Approved, Nutraceutical, Vet_approved Phase 2, Phase 3 59-30-3 6037
10
Vitamin A Approved, Nutraceutical, Vet_approved Phase 2, Phase 3 22737-96-8, 68-26-8, 11103-57-4 9904001 445354
11
Thiamine Approved, Investigational, Nutraceutical, Vet_approved Phase 2, Phase 3 59-43-8, 70-16-6 1130
12
Prednisolone hemisuccinate Experimental Phase 3 2920-86-7
13 Micronutrients Phase 2, Phase 3
14 Trace Elements Phase 2, Phase 3
15 Vitamins Phase 2, Phase 3
16 Retinol palmitate Phase 2, Phase 3
17 Vitamin B Complex Phase 2, Phase 3
18 Thiamin Phase 2, Phase 3
19 retinol Phase 2, Phase 3
20 Nutrients Phase 2, Phase 3
21 Folate Phase 2, Phase 3
22 Vitamin B9 Phase 2, Phase 3
23 Hormones Phase 3
24 Gastrointestinal Agents Phase 3
25 Hormone Antagonists Phase 3
26 Cytochrome P-450 CYP3A Inhibitors Phase 3
27 Cytochrome P-450 Enzyme Inhibitors Phase 3
28 Methylprednisolone Acetate Phase 3
29 Antineoplastic Agents, Hormonal Phase 3
30 Antiemetics Phase 3
31 Anti-Infective Agents Phase 3
32 Antifungal Agents Phase 3
33 Neuroprotective Agents Phase 3
34 Protective Agents Phase 3
35 glucocorticoids Phase 3
36 Anti-Inflammatory Agents Phase 3
37 Poractant alfa Approved Phase 2 129069-19-8
38 Pharmaceutical Solutions Phase 2
39 Respiratory System Agents Phase 2
40 Pulmonary Surfactants Phase 2

Interventional clinical trials:

(show all 14)
# Name Status NCT ID Phase Drugs
1 Randomized, Placebo-Controlled, Double-Blind Clinical Trial to Evaluate the Safety and Efficacy of Low-Dose Glucocorticoid Infusion in Acute Respiratory Distress Syndrome (ARDS) Unknown status NCT00562835 Phase 2, Phase 3 Methylprednisolone
2 Acute Respiratory Distress Syndrome Clinical Network (ARDSNet) Completed NCT00000579 Phase 3 Lysofylline;Methylprednisolone;Ketoconazole
3 A Phase IIa, Placebo Controlled, Multicenter Pilot Study to Evaluate the Safety and Efficacy of BIO-11006 Inhalation Solution in Patients With Acute Respiratory Distress Syndrome Recruiting NCT03202394 Phase 2 BIO-11006;Placebo
4 Randomized Controlled Phase II Trial of Poractant Alfa (Curosurf®) by Fiberoptic Bronchoscopy-directed Endobronchial Administration in Acute Respiratory Distress Syndrome (ARDS) Due to COVID-19 Viral Pneumonia Not yet recruiting NCT04384731 Phase 2 poractant alfa
5 A Multicenter, Randomized, Controlled Trial Comparing the Safety and Effectiveness of SURFAXIN® (Lucinactant) Delivered Via Bronchopulmonary Segmental Lavage to Standard of Care in Patients With Acute Respiratory Distress Syndrome (ARDS). Terminated NCT00215553 Phase 2 A.1 Lucinactant;A.2 Lucinactant;A.3 Lucinactant;A.4 Lucinactant;B.1 Lucinactant;B.2 Lucinactant
6 Prone Positioning and Spontaneous Breathing: a Feasibility Study Active, not recruiting NCT03768154 Phase 1
7 Goal Directed Mechanical Ventilation Aimed at Optimal Lung Compliance Approach Guided by Esophageal Pressure in Acute Respiratory Failure. Unknown status NCT01668368
8 Driving Pressure and Mortality: in the Pediatric Intensive Care Unit (PICU) Completed NCT04419376
9 Effectiveness and Costs of Remote Monitoring for Clinical Trials Completed NCT01151995
10 Lung Protection in Acute Respiratory Distress Syndrome Using Neurally Adjusted Ventilatory Assist Recruiting NCT03868982
11 The Effect of Intensive Care Unit Therapies and Mechanical Ventilation Strategy on Long Term Outcome in Pediatric ARDS A Follow-up of the Real-time Effort Driven VENTilator Management Study (REDvent) Recruiting NCT03709199
12 Human Umbilical Cord Derived Mesenchymal Stem Cells Therapy in Acute Respiratory Distress Syndrome Recruiting NCT03608592
13 Pediatric Acute Respiratory Distress Syndrome: Determining Post-discharge Outcomes, the Effect of Early Diagnosis, and Identifying Inflammatory Signatures to Better Understand Disease Mechanism Not yet recruiting NCT03585582
14 A Clinical Trial of Nebulized Surfactant for the Treatment of Moderate to Severe COVID-19 Not yet recruiting NCT04362059

Search NIH Clinical Center for Adult Acute Respiratory Distress Syndrome

Genetic Tests for Adult Acute Respiratory Distress Syndrome

Anatomical Context for Adult Acute Respiratory Distress Syndrome

MalaCards organs/tissues related to Adult Acute Respiratory Distress Syndrome:

40
Lung, Endothelial

Publications for Adult Acute Respiratory Distress Syndrome

Articles related to Adult Acute Respiratory Distress Syndrome:

(show top 50) (show all 82)
# Title Authors PMID Year
1
[Emergency department : COVID-19 crisis and organizational aspects]. 61
32374538 2020
2
Increased p300/CBP expression in acute respiratory distress syndrome is associated with interleukin-17 and prognosis. 61
32298537 2020
3
Comparison of Fixed-Dose Inhaled Epoprostenol and Inhaled Nitric Oxide for Acute Respiratory Distress Syndrome in Critically Ill Adults. 61
32133901 2020
4
The impact of high frequency oscillatory ventilation on mortality in paediatric acute respiratory distress syndrome. 61
32005285 2020
5
Pertinent clinical outcomes in pediatric survivors of pediatric acute respiratory distress syndrome (PARDS): a narrative review. 61
31728366 2019
6
Novel Risk Factors for Posttraumatic Stress Disorder Symptoms in Family Members of Acute Respiratory Distress Syndrome Survivors. 61
30985448 2019
7
What links ventilator driving pressure with survival in the acute respiratory distress syndrome? A computational study. 61
30744629 2019
8
Effect of surfactant administration on outcomes of adult patients in acute respiratory distress syndrome: a meta-analysis of randomized controlled trials. 61
30626363 2019
9
Comparison of Hemodynamic Monitoring between Transesophageal Doppler and Ultrasonography-Guided Inferior Vena Cava Distensibility in Supine versus Prone Position: A Pilot Study. 61
30662221 2018
10
[Advances in the diagnosis and treatment of pediatric acute respiratory distress syndrome]. 61
30210022 2018
11
Advanced modes of mechanical ventilation and optimal targeting schemes. 61
30136011 2018
12
[Influence of enteral nutrition initiation timing on curative effect and prognosis of acute respiratory distress syndrome patients with mechanical ventilation]. 61
30009734 2018
13
A Comparative Analysis of Survival Prediction Using PRESERVE and RESP Scores. 61
28410641 2017
14
Venovenous Versus Venoarterial Extracorporeal Membrane Oxygenation for Adult Patients With Acute Respiratory Distress Syndrome Requiring Precannulation Hemodynamic Support: A Review of the ELSO Registry. 61
28190548 2017
15
Predicted body weight relationships for protective ventilation - unisex proposals from pre-term through to adult. 61
28535820 2017
16
Severe Pediatric Acute Respiratory Distress Syndrome Due to Scrub Typhus: Successful Ventilation with Airway Pressure Release Ventilation Mode after Becoming Refractory to Protective Ventilation. 61
28584437 2017
17
Serial Lactate Measurements as a Prognostic Tool in Venovenous Extracorporeal Membrane Oxygenation Support. 61
27666781 2017
18
Inhaled nitric oxide in adult patients with acute respiratory distress syndrome. 61
28236803 2017
19
Outcomes and survival prediction models for severe adult acute respiratory distress syndrome treated with extracorporeal membrane oxygenation. 61
27919283 2016
20
Associations between ventilator settings during extracorporeal membrane oxygenation for refractory hypoxemia and outcome in patients with acute respiratory distress syndrome: a pooled individual patient data analysis : Mechanical ventilation during ECMO. 61
27586996 2016
21
Mechanical Ventilation in Patients with the Acute Respiratory Distress Syndrome and Treated with Extracorporeal Membrane Oxygenation: Impact on Hospital and 30 Day Postdischarge Survival. 61
27347707 2016
22
Circulating markers of endothelial and alveolar epithelial dysfunction are associated with mortality in pediatric acute respiratory distress syndrome. 61
27101828 2016
23
High frequency oscillatory ventilation for adult ARDS: Is this the end of the road? 61
27660253 2016
24
Relevant Outcomes in Pediatric Acute Respiratory Distress Syndrome Studies. 61
27242980 2016
25
BPD Following Preterm Birth: A Model for Chronic Lung Disease and a Substrate for ARDS in Childhood. 61
27379219 2016
26
Controversies in the Management of Severe ARDS: Optimal Ventilator Management and Use of Rescue Therapies. 61
26595042 2015
27
Pulmonary specific ancillary treatment for pediatric acute respiratory distress syndrome: proceedings from the Pediatric Acute Lung Injury Consensus Conference. 61
26035366 2015
28
Pediatric acute respiratory distress syndrome: definition, incidence, and epidemiology: proceedings from the Pediatric Acute Lung Injury Consensus Conference. 61
26035358 2015
29
Extracorporeal membrane oxygenation for acute respiratory distress syndrome. 61
27408728 2015
30
Impact of Corticosteroids on Mortality in Patients with Acute Respiratory Distress Syndrome: A Systematic Review and Meta-analysis. 61
26267908 2015
31
Compliance versus dead space for optimum positive end expiratory pressure determination in acute respiratory distress syndrome. 61
25136189 2014
32
[High-frequency oscillatory ventilation in patients with acute respiratory distress syndrome: a meta-analysis]. 61
25327856 2014
33
D-dimers as an early marker for oxygenator exchange in extracorporeal membrane oxygenation. 61
24508200 2014
34
Influenza A (H1N1) vs non-H1N1 ARDS: analysis of clinical course. 61
24508203 2014
35
Is high-frequency oscillatory ventilation more effective and safer than conventional protective ventilation in adult acute respiratory distress syndrome patients? A meta-analysis of randomized controlled trials. 61
24887179 2014
36
Efficacy and adverse events of high-frequency oscillatory ventilation in adult patients with acute respiratory distress syndrome: a meta-analysis. 61
24886674 2014
37
The acute respiratory distress syndrome: incidence and mortality, has it changed? 61
24309954 2014
38
High-frequency oscillatory ventilation for early acute respiratory distress syndrome in adults. 61
24356284 2014
39
Early induction of uncoupling protein-2 in pulmonary macrophages in hyperoxia-associated lung injury. 61
23905971 2013
40
Neuromuscular blocking agents in acute respiratory distress syndrome: a systematic review and meta-analysis of randomized controlled trials. 61
23497608 2013
41
Critical care paper review 2012. 61
23101019 2012
42
The role of high-frequency oscillatory ventilation in the treatment of acute respiratory failure in adults. 61
22157255 2012
43
Increased extravascular lung water reduces the efficacy of alveolar recruitment maneuver in acute respiratory distress syndrome. 61
22649717 2012
44
Resolution of organ functional scores to predict the outcome in adult acute respiratory distress syndrome patients receiving high-frequency oscillatory ventilation. 61
22027886 2011
45
Extracorporeal membrane oxygenation in adult acute respiratory distress syndrome. 61
21742220 2011
46
[Interhospital transport of patients requiring extracorporeal membrane oxygenation ECMO]. 61
22011921 2011
47
A practical approach to adult acute respiratory distress syndrome. 61
21572751 2010
48
Genetic susceptibility in acute lung injury and acute respiratory distress syndrome. 61
25307334 2009
49
Angiotensin-converting enzyme D allele does not influence susceptibility to acute hypoxic respiratory failure in children. 61
18787808 2008
50
Angiotensin-converting enzyme genotype may predict survival following major trauma. 61
18955615 2008

Variations for Adult Acute Respiratory Distress Syndrome

Expression for Adult Acute Respiratory Distress Syndrome

Search GEO for disease gene expression data for Adult Acute Respiratory Distress Syndrome.

Pathways for Adult Acute Respiratory Distress Syndrome

GO Terms for Adult Acute Respiratory Distress Syndrome

Sources for Adult Acute Respiratory Distress Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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