MCID: ADL053
MIFTS: 35

Adult Astrocytic Tumour

Categories: Cancer diseases, Neuronal diseases

Aliases & Classifications for Adult Astrocytic Tumour

MalaCards integrated aliases for Adult Astrocytic Tumour:

Name: Adult Astrocytic Tumour 12 15
Adult Astrocytic Tumors 73
Adult Astrocytoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:3076
NCIt 50 C7049
UMLS 73 C1332183

Summaries for Adult Astrocytic Tumour

MalaCards based summary : Adult Astrocytic Tumour, also known as adult astrocytic tumors, is related to oligodendroglioma and glioblastoma. An important gene associated with Adult Astrocytic Tumour is ATRX (ATRX, Chromatin Remodeler), and among its related pathways/superpathways are Degradation of the extracellular matrix and G-protein signaling Regulation of p38 and JNK signaling mediated by G-proteins. The drugs Entinostat and Liver Extracts have been mentioned in the context of this disorder. Affiliated tissues include liver, brain and bone, and related phenotypes are neoplasm and vision/eye

Related Diseases for Adult Astrocytic Tumour

Diseases related to Adult Astrocytic Tumour via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 82)
# Related Disease Score Top Affiliating Genes
1 oligodendroglioma 29.6 IDH1 IDH2 PTEN
2 glioblastoma 29.3 H3F3A IDH1 IDH2 PTEN
3 interval angle-closure glaucoma 10.2 IDH1 IDH2
4 adult oligodendroglioma 10.2 IDH1 IDH2
5 enchondroma 10.2 IDH1 IDH2
6 intracranial chondrosarcoma 10.2 IDH1 IDH2
7 cytogenetically normal acute myeloid leukemia 10.2 IDH1 IDH2
8 chondroblastic osteosarcoma 10.2 IDH1 IDH2
9 multiple enchondromatosis, maffucci type 10.2 IDH1 IDH2
10 intraductal papilloma 10.2 IDH1 IDH2
11 pilocytic astrocytoma of cerebellum 10.2 IDH1 IDH2
12 spindle cell hemangioma 10.2 IDH1 IDH2
13 periosteal chondrosarcoma 10.2 IDH1 IDH2
14 superior limbic keratoconjunctivitis 10.2 MMP1 MMP3
15 diffuse infiltrative lymphocytosis syndrome 10.2 IDH1 IDH2
16 tendinopathy 10.2 MMP1 MMP3
17 drug-induced mental disorder 10.2 IDH1 IDH2
18 drug psychosis 10.2 IDH1 IDH2
19 undifferentiated pleomorphic sarcoma 10.2 IDH1 IDH2
20 conjunctivochalasis 10.1 MMP1 MMP3
21 nodular ganglioneuroblastoma 10.1 ATRX BDNF
22 gemistocytic astrocytoma 10.1 IDH2 PTEN
23 bone giant cell sarcoma 10.1 H3F3A H3F3B
24 malignant giant cell tumor 10.1 H3F3A H3F3B
25 astrocytoma 10.1
26 glioma susceptibility 1 10.1 H3F3A IDH1 IDH2
27 coronary artery aneurysm 10.1 MMP1 MMP3 MMP7
28 brain stem cancer 10.1 H3F3A H3F3B
29 cannabis abuse 10.1 BDNF NGF
30 corneal edema 10.1 MMP1 MMP3
31 neuropathy, hereditary sensory and autonomic, type v 10.1 BDNF NGF
32 diffuse intrinsic pontine glioma 10.1 H3F3A H3F3B
33 gliomatosis cerebri 10.1 IDH1 PTEN
34 septic arthritis 10.0 MMP1 MMP3
35 focal myositis 10.0 MMP7 MMP9
36 rheumatoid nodulosis 10.0 MMP3 MMP9
37 senile ectropion 10.0 MMP7 MMP9
38 brain glioblastoma multiforme 10.0 MMP7 MMP9
39 chondroblastoma 10.0 H3F3A H3F3B
40 blepharochalasis 10.0 MMP3 MMP9
41 gingival hypertrophy 10.0 MMP3 MMP9
42 chronic actinic dermatitis 10.0 MMP1 MMP9
43 tendinosis 10.0 BDNF MMP1 MMP3
44 spinal cord astrocytoma 10.0 H3F3A H3F3B IDH1
45 pediatric multiple sclerosis 10.0 MMP7 MMP9
46 fibrillary astrocytoma 10.0 ATRX H3F3A IDH1 IDH2
47 epidermolysis bullosa dystrophica 10.0 MMP1 MMP3
48 chromoblastomycosis 10.0 MMP1 MMP9
49 chondrosarcoma 10.0 IDH1 IDH2 MMP1 MMP3
50 paine syndrome 10.0 BDNF NGF

Graphical network of the top 20 diseases related to Adult Astrocytic Tumour:



Diseases related to Adult Astrocytic Tumour

Symptoms & Phenotypes for Adult Astrocytic Tumour

MGI Mouse Phenotypes related to Adult Astrocytic Tumour:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 neoplasm MP:0002006 9.35 IDH2 MMP1 MMP7 MMP9 PTEN
2 vision/eye MP:0005391 9.1 ATRX BDNF MMP7 MMP9 NGF PTEN

Drugs & Therapeutics for Adult Astrocytic Tumour

Drugs for Adult Astrocytic Tumour (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Entinostat Investigational Phase 1 209783-80-2
2 Liver Extracts Phase 1
3 Histone Deacetylase Inhibitors Phase 1
4 Cola Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 MS-275 in Treating Patients With Advanced Solid Tumors or Lymphoma Completed NCT00020579 Phase 1 entinostat
2 Study of Genes and Environment in Patients With Cancer in East Anglia, Trent, or West Midlands Regions of the United Kingdom Unknown status NCT00757614
3 Decision Making About Participating in Pharmacokinetic Studies in Patients Enrolled in a Phase I Treatment Clinical Trial Completed NCT00890435

Search NIH Clinical Center for Adult Astrocytic Tumour

Genetic Tests for Adult Astrocytic Tumour

Anatomical Context for Adult Astrocytic Tumour

MalaCards organs/tissues related to Adult Astrocytic Tumour:

41
Liver, Brain, Bone, Heart, Lymph Node, Spinal Cord, Cerebellum

Publications for Adult Astrocytic Tumour

Articles related to Adult Astrocytic Tumour:

# Title Authors Year
1
p53 protein alterations in adult astrocytic tumors and oligodendrogliomas. ( 15269478 )
2004
2
Prognostic scoring in adult astrocytic tumors using patient age, histopathological grade, and DNA histogram type. ( 8169628 )
1994

Variations for Adult Astrocytic Tumour

Expression for Adult Astrocytic Tumour

Search GEO for disease gene expression data for Adult Astrocytic Tumour.

Pathways for Adult Astrocytic Tumour

Pathways related to Adult Astrocytic Tumour according to GeneCards Suite gene sharing:

(show all 17)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.48 MMP1 MMP3 MMP7 MMP9
2
Show member pathways
11.95 MMP1 MMP3 MMP7 MMP9
3 11.94 H3F3A H3F3B MMP3 MMP9
4 11.93 MMP1 MMP7 MMP9
5
Show member pathways
11.79 MMP3 MMP7 MMP9
6 11.73 MMP1 MMP3 MMP9
7 11.58 MMP3 MMP7 MMP9
8
Show member pathways
11.55 MMP1 MMP3 MMP7 MMP9
9 11.46 BDNF MMP3 MMP9
10
Show member pathways
11.38 MMP1 MMP3 MMP9
11 11.1 MMP1 MMP9
12 11.09 MMP1 MMP3 MMP9
13 11.08 H3F3A H3F3B
14
Show member pathways
11.08 BDNF MMP3 MMP7 NGF
15 10.71 MMP1 MMP3 MMP7 MMP9
16
Show member pathways
10.59 IDH1 IDH2
17 10.56 MMP1 MMP7 MMP9

GO Terms for Adult Astrocytic Tumour

Cellular components related to Adult Astrocytic Tumour according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular matrix GO:0031012 9.56 MMP1 MMP3 MMP7 MMP9
2 nuclear chromosome, telomeric region GO:0000784 9.5 ATRX H3F3A H3F3B
3 extracellular region GO:0005576 9.32 BDNF H3F3A H3F3B IDH1 MMP1 MMP3
4 Barr body GO:0001740 9.16 H3F3A H3F3B
5 nuclear chromosome GO:0000228 9.13 ATRX H3F3A H3F3B

Biological processes related to Adult Astrocytic Tumour according to GeneCards Suite gene sharing:

(show all 30)
# Name GO ID Score Top Affiliating Genes
1 nucleosome assembly GO:0006334 9.75 ATRX H3F3A H3F3B
2 multicellular organism growth GO:0035264 9.73 ATRX H3F3A H3F3B
3 memory GO:0007613 9.71 BDNF NGF PTEN
4 oogenesis GO:0048477 9.65 H3F3A H3F3B
5 tricarboxylic acid cycle GO:0006099 9.64 IDH1 IDH2
6 nucleus organization GO:0006997 9.64 H3F3A H3F3B
7 positive regulation of DNA binding GO:0043388 9.63 MMP9 NGF
8 peripheral nervous system development GO:0007422 9.63 BDNF NGF
9 regulation of neuron differentiation GO:0045664 9.62 BDNF NGF
10 telomere organization GO:0032200 9.62 H3F3A H3F3B
11 2-oxoglutarate metabolic process GO:0006103 9.61 IDH1 IDH2
12 neurotrophin TRK receptor signaling pathway GO:0048011 9.61 BDNF NGF
13 embryo implantation GO:0007566 9.61 H3F3A H3F3B MMP9
14 muscle cell differentiation GO:0042692 9.6 H3F3A H3F3B
15 positive regulation of protein oligomerization GO:0032461 9.59 MMP1 MMP3
16 nerve development GO:0021675 9.58 BDNF NGF
17 nerve growth factor signaling pathway GO:0038180 9.57 BDNF NGF
18 NADP metabolic process GO:0006739 9.55 IDH1 IDH2
19 positive regulation of collateral sprouting GO:0048672 9.52 BDNF NGF
20 positive regulation of receptor binding GO:1900122 9.51 BDNF MMP9
21 isocitrate metabolic process GO:0006102 9.49 IDH1 IDH2
22 regulation of neuroinflammatory response GO:0150077 9.48 MMP3 MMP9
23 pericentric heterochromatin assembly GO:0031508 9.46 H3F3A H3F3B
24 regulation of centromere complex assembly GO:0090230 9.4 H3F3A H3F3B
25 glyoxylate cycle GO:0006097 9.37 IDH1 IDH2
26 DNA replication-independent nucleosome assembly GO:0006336 9.33 ATRX H3F3A H3F3B
27 negative regulation of chromosome condensation GO:1902340 9.32 H3F3A H3F3B
28 telomeric heterochromatin assembly GO:0031509 9.26 H3F3A H3F3B
29 extracellular matrix disassembly GO:0022617 9.26 MMP1 MMP3 MMP7 MMP9
30 collagen catabolic process GO:0030574 8.92 MMP1 MMP3 MMP7 MMP9

Molecular functions related to Adult Astrocytic Tumour according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hydrolase activity GO:0016787 9.88 ATRX MMP1 MMP3 MMP7 MMP9 PTEN
2 peptidase activity GO:0008233 9.76 MMP1 MMP3 MMP7 MMP9
3 serine-type endopeptidase activity GO:0004252 9.62 MMP1 MMP3 MMP7 MMP9
4 metallopeptidase activity GO:0008237 9.56 MMP1 MMP3 MMP7 MMP9
5 endopeptidase activity GO:0004175 9.54 MMP1 MMP3 MMP9
6 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GO:0016616 9.48 IDH1 IDH2
7 RNA polymerase II core promoter sequence-specific DNA binding GO:0000979 9.43 H3F3A H3F3B
8 isocitrate dehydrogenase (NADP+) activity GO:0004450 9.16 IDH1 IDH2
9 isocitrate dehydrogenase activity GO:0004448 8.96 IDH1 IDH2
10 metalloendopeptidase activity GO:0004222 8.92 MMP1 MMP3 MMP7 MMP9

Sources for Adult Astrocytic Tumour

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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