MCID: ADL053
MIFTS: 32

Adult Astrocytic Tumour

Categories: Cancer diseases

Aliases & Classifications for Adult Astrocytic Tumour

MalaCards integrated aliases for Adult Astrocytic Tumour:

Name: Adult Astrocytic Tumour 12 15
Adult Astrocytic Tumors 73
Adult Astrocytoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:3076
NCIt 50 C7049
UMLS 73 C1332183

Summaries for Adult Astrocytic Tumour

MalaCards based summary : Adult Astrocytic Tumour, also known as adult astrocytic tumors, is related to oligodendroglioma and glioblastoma. An important gene associated with Adult Astrocytic Tumour is ATRX (ATRX, Chromatin Remodeler), and among its related pathways/superpathways are Degradation of the extracellular matrix and Transcriptional misregulation in cancer. The drugs Entinostat and Histone Deacetylase Inhibitors have been mentioned in the context of this disorder. Affiliated tissues include liver, and related phenotypes are neoplasm and vision/eye

Related Diseases for Adult Astrocytic Tumour

Diseases related to Adult Astrocytic Tumour via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 75)
# Related Disease Score Top Affiliating Genes
1 oligodendroglioma 29.4 IDH1 IDH2 PTEN
2 glioblastoma 28.7 H3F3A IDH1 IDH2 PTEN
3 interval angle-closure glaucoma 10.8 IDH1 IDH2
4 adult oligodendroglioma 10.8 IDH1 IDH2
5 enchondroma 10.8 IDH1 IDH2
6 intracranial chondrosarcoma 10.7 IDH1 IDH2
7 cytogenetically normal acute myeloid leukemia 10.7 IDH1 IDH2
8 intraductal papilloma 10.7 IDH1 IDH2
9 multiple enchondromatosis, maffucci type 10.7 IDH1 IDH2
10 pilocytic astrocytoma of cerebellum 10.7 IDH1 IDH2
11 spindle cell hemangioma 10.7 IDH1 IDH2
12 periosteal chondrosarcoma 10.6 IDH1 IDH2
13 superior limbic keratoconjunctivitis 10.6 MMP1 MMP3
14 undifferentiated pleomorphic sarcoma 10.6 IDH1 IDH2
15 drug-induced mental disorder 10.5 IDH1 IDH2
16 drug psychosis 10.5 IDH1 IDH2
17 nodular ganglioneuroblastoma 10.4 ATRX BDNF
18 conjunctivochalasis 10.4 MMP1 MMP3
19 bone giant cell sarcoma 10.4 H3F3A H3F3B
20 diffuse infiltrative lymphocytosis syndrome 10.4 IDH1 IDH2
21 malignant giant cell tumor 10.4 H3F3A H3F3B
22 gemistocytic astrocytoma 10.4 IDH2 PTEN
23 chondroblastic osteosarcoma 10.4 H3F3A IDH1 IDH2
24 glioma susceptibility 1 10.4 H3F3A IDH1 IDH2
25 brain stem cancer 10.3 H3F3A H3F3B
26 corneal edema 10.3 MMP1 MMP3
27 coronary artery aneurysm 10.2 MMP1 MMP3 MMP7
28 cannabis abuse 10.2 BDNF NGF
29 2-hydroxyglutaric aciduria 10.2 IDH1 IDH2
30 diffuse intrinsic pontine glioma 10.2 H3F3A H3F3B
31 gliomatosis cerebri 10.2 IDH1 PTEN
32 focal myositis 10.1 MMP7 MMP9
33 chondroblastoma 10.1 H3F3A H3F3B
34 rheumatoid nodulosis 10.1 MMP3 MMP9
35 senile ectropion 10.1 MMP7 MMP9
36 brain glioblastoma multiforme 10.1 MMP7 MMP9
37 spinal cord astrocytoma 10.1 H3F3A H3F3B IDH1
38 gingival hypertrophy 10.0 MMP3 MMP9
39 fibrillary astrocytoma 10.0 ATRX H3F3A IDH1 IDH2
40 blepharochalasis 10.0 MMP3 MMP9
41 pediatric multiple sclerosis 10.0 MMP7 MMP9
42 tendinosis 10.0 BDNF MMP1 MMP3
43 chronic actinic dermatitis 10.0 MMP1 MMP9
44 astrocytoma 9.9
45 epidermolysis bullosa dystrophica 9.9 MMP1 MMP3
46 traumatic brain injury 9.9 BDNF NGF
47 chromoblastomycosis 9.9 MMP1 MMP9
48 chondrosarcoma 9.9 IDH1 IDH2 MMP1 MMP3
49 breast papillary carcinoma 9.9 IDH1 IDH2
50 ocular dominance 9.9 BDNF NGF

Graphical network of the top 20 diseases related to Adult Astrocytic Tumour:



Diseases related to Adult Astrocytic Tumour

Symptoms & Phenotypes for Adult Astrocytic Tumour

MGI Mouse Phenotypes related to Adult Astrocytic Tumour:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 neoplasm MP:0002006 9.35 MMP7 MMP9 PTEN IDH2 MMP1
2 vision/eye MP:0005391 9.1 MMP7 MMP9 NGF PTEN ATRX BDNF

Drugs & Therapeutics for Adult Astrocytic Tumour

Drugs for Adult Astrocytic Tumour (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Entinostat Investigational Phase 1 209783-80-2
2 Histone Deacetylase Inhibitors Phase 1
3 Liver Extracts Phase 1
4 Cola Nutraceutical Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 MS-275 in Treating Patients With Advanced Solid Tumors or Lymphoma Completed NCT00020579 Phase 1 entinostat
2 Study of Genes and Environment in Patients With Cancer in East Anglia, Trent, or West Midlands Regions of the United Kingdom Unknown status NCT00757614
3 Decision Making About Participating in Pharmacokinetic Studies in Patients Enrolled in a Phase I Treatment Clinical Trial Completed NCT00890435

Search NIH Clinical Center for Adult Astrocytic Tumour

Genetic Tests for Adult Astrocytic Tumour

Anatomical Context for Adult Astrocytic Tumour

MalaCards organs/tissues related to Adult Astrocytic Tumour:

41
Liver

Publications for Adult Astrocytic Tumour

Articles related to Adult Astrocytic Tumour:

# Title Authors Year
1
p53-independent mechanisms regulate the P2-MDM2 promoter in adult astrocytic tumours. ( 18781178 )
2008
2
Galectin-3 and galectin-3-binding site expression in human adult astrocytic tumours and related angiogenesis. ( 10476049 )
1999

Variations for Adult Astrocytic Tumour

Expression for Adult Astrocytic Tumour

Search GEO for disease gene expression data for Adult Astrocytic Tumour.

Pathways for Adult Astrocytic Tumour

GO Terms for Adult Astrocytic Tumour

Cellular components related to Adult Astrocytic Tumour according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular matrix GO:0031012 9.56 MMP1 MMP3 MMP7 MMP9
2 nuclear chromosome, telomeric region GO:0000784 9.5 ATRX H3F3A H3F3B
3 extracellular region GO:0005576 9.32 BDNF H3F3A H3F3B IDH1 MMP1 MMP3
4 Barr body GO:0001740 9.16 H3F3A H3F3B
5 nuclear chromosome GO:0000228 9.13 ATRX H3F3A H3F3B

Biological processes related to Adult Astrocytic Tumour according to GeneCards Suite gene sharing:

(show all 28)
# Name GO ID Score Top Affiliating Genes
1 nucleosome assembly GO:0006334 9.73 ATRX H3F3A H3F3B
2 multicellular organism growth GO:0035264 9.7 ATRX H3F3A H3F3B
3 memory GO:0007613 9.69 BDNF NGF PTEN
4 oogenesis GO:0048477 9.64 H3F3A H3F3B
5 tricarboxylic acid cycle GO:0006099 9.63 IDH1 IDH2
6 regulation of neuron differentiation GO:0045664 9.63 BDNF NGF
7 telomere organization GO:0032200 9.62 H3F3A H3F3B
8 positive regulation of DNA binding GO:0043388 9.62 MMP9 NGF
9 nucleus organization GO:0006997 9.61 H3F3A H3F3B
10 peripheral nervous system development GO:0007422 9.61 BDNF NGF
11 embryo implantation GO:0007566 9.61 H3F3A H3F3B MMP9
12 2-oxoglutarate metabolic process GO:0006103 9.6 IDH1 IDH2
13 muscle cell differentiation GO:0042692 9.59 H3F3A H3F3B
14 positive regulation of protein oligomerization GO:0032461 9.58 MMP1 MMP3
15 nerve development GO:0021675 9.58 BDNF NGF
16 locomotion GO:0040011 9.57 BDNF NGF
17 nerve growth factor signaling pathway GO:0038180 9.55 BDNF NGF
18 positive regulation of collateral sprouting GO:0048672 9.54 BDNF NGF
19 positive regulation of receptor binding GO:1900122 9.49 BDNF MMP9
20 isocitrate metabolic process GO:0006102 9.48 IDH1 IDH2
21 pericentric heterochromatin assembly GO:0031508 9.46 H3F3A H3F3B
22 regulation of centromere complex assembly GO:0090230 9.4 H3F3A H3F3B
23 telomeric heterochromatin assembly GO:0031509 9.37 H3F3A H3F3B
24 DNA replication-independent nucleosome assembly GO:0006336 9.33 ATRX H3F3A H3F3B
25 negative regulation of chromosome condensation GO:1902340 9.32 H3F3A H3F3B
26 glyoxylate cycle GO:0006097 9.26 IDH1 IDH2
27 extracellular matrix disassembly GO:0022617 9.26 MMP1 MMP3 MMP7 MMP9
28 collagen catabolic process GO:0030574 8.92 MMP1 MMP3 MMP7 MMP9

Molecular functions related to Adult Astrocytic Tumour according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hydrolase activity GO:0016787 9.88 ATRX MMP1 MMP3 MMP7 MMP9 PTEN
2 peptidase activity GO:0008233 9.73 MMP1 MMP3 MMP7 MMP9
3 magnesium ion binding GO:0000287 9.63 IDH1 IDH2 PTEN
4 serine-type endopeptidase activity GO:0004252 9.62 MMP1 MMP3 MMP7 MMP9
5 metallopeptidase activity GO:0008237 9.56 MMP1 MMP3 MMP7 MMP9
6 endopeptidase activity GO:0004175 9.54 MMP1 MMP3 MMP9
7 isocitrate dehydrogenase activity GO:0004448 9.16 IDH1 IDH2
8 isocitrate dehydrogenase (NADP+) activity GO:0004450 8.96 IDH1 IDH2
9 metalloendopeptidase activity GO:0004222 8.92 MMP1 MMP3 MMP7 MMP9

Sources for Adult Astrocytic Tumour

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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