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MCID: ADL053
MIFTS: 33

Adult Astrocytic Tumour

Categories: Bone diseases, Cancer diseases, Neuronal diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Adult Astrocytic Tumour

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MalaCards integrated aliases for Adult Astrocytic Tumour:

Name: Adult Astrocytic Tumour 12 15
Adult Astrocytic Tumors 71
Adult Astrocytoma 12

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Bone diseases Neuronal diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:3076
NCIt 50 C7049
UMLS 71 C1332183
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Summaries for Adult Astrocytic Tumour

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MalaCards based summary : Adult Astrocytic Tumour, also known as adult astrocytic tumors, is related to glioma susceptibility 1 and high-grade astrocytoma. An important gene associated with Adult Astrocytic Tumour is LUC7L2 (LUC7 Like 2, Pre-MRNA Splicing Factor), and among its related pathways/superpathways are Endometrial cancer and Pathways in cancer. The drugs Parathyroid hormone and Entinostat have been mentioned in the context of this disorder. Affiliated tissues include liver and brain, and related phenotypes are neoplasm and pigmentation

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Related Diseases for Adult Astrocytic Tumour

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Diseases related to Adult Astrocytic Tumour via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 224)
# Related Disease Score Top Affiliating Genes
1 glioma susceptibility 1 30.4 TP53 IDH2 IDH1 H3-3A
2 high-grade astrocytoma 29.7 TP53 PTEN IDH1 ATRX
3 glioblastoma 28.3 TP53 PTEN PDGFRA MDM2 IDH2 IDH1
4 oligodendroglioma 28.2 TP53 PTEN PDGFRA MDM2 IDH2 IDH1
5 malignant astrocytoma 28.1 TP53 PTEN PDGFRA MDM2 KIAA1549 IDH2
6 enchondroma 10.4 IDH2 IDH1
7 pediatric meningioma 10.4 LUC7L2 KIAA1549
8 cytogenetically normal acute myeloid leukemia 10.4 IDH2 IDH1
9 temporal lobe neoplasm 10.4 IDH1 ATRX
10 intracranial chondrosarcoma 10.4 IDH2 IDH1
11 periosteal chondrosarcoma 10.4 IDH2 IDH1
12 brain sarcoma 10.3 TP53 KIAA1549
13 pilocytic astrocytoma of cerebellum 10.3 KIAA1549 IDH1
14 frontal lobe neoplasm 10.3 TP53 IDH1
15 laryngeal neuroendocrine tumor 10.3 TP53 IDH1
16 juxtacortical chondroma 10.3 IDH2 IDH1
17 rhabdoid tumor predisposition syndrome 1 10.3 TP53 ATRX
18 cerebellar astrocytoma 10.3 KIAA1549 IDH1
19 juvenile astrocytoma 10.3 LUC7L2 KIAA1549 IDH1
20 dysembryoplastic neuroepithelial tumor 10.3 LUC7L2 KIAA1549 IDH1
21 malignant giant cell tumor 10.3 H3-3B H3-3A
22 enchondromatosis, multiple, ollier type 10.3 IDH2 IDH1 ATRX
23 spinal cord oligodendroglioma 10.3 TP53 IDH1 ATRX
24 cerebellum cancer 10.2 TP53 KIAA1549 IDH1
25 cerebral ventricle cancer 10.2 TP53 IDH1 ATRX
26 cerebrum cancer 10.2 TP53 IDH1 ATRX
27 low grade glioma 10.2 IDH2 IDH1
28 ring chromosome 7 10.2 TP53 MDM2
29 ring chromosome 10.2 TP53 MDM2
30 actinic cheilitis 10.2 TP53 MDM2
31 undifferentiated embryonal sarcoma of the liver 10.2 TP53 MDM2
32 embryonal sarcoma 10.2 TP53 MDM2
33 bile duct adenocarcinoma 10.2 TP53 IDH2 IDH1
34 intrahepatic cholangiocarcinoma 10.2 TP53 IDH2 IDH1
35 periosteal osteogenic sarcoma 10.2 TP53 MDM2
36 benign ependymoma 10.2 PTEN KIAA1549 IDH1
37 gangliocytoma 10.2 PTEN KIAA1549
38 alpha thalassemia-x-linked intellectual disability syndrome 10.2 H3-3B H3-3A ATRX
39 maxillary sinus adenocarcinoma 10.2 TP53 MDM2
40 synchronous bilateral breast carcinoma 10.2 TP53 PTEN
41 clear cell chondrosarcoma 10.2 IDH2 H3-3B H3-3A
42 endometrioid ovary carcinoma 10.2 TP53 PTEN
43 peripheral osteosarcoma 10.2 TP53 MDM2
44 soft tissue sarcoma 10.2 TP53 MDM2
45 bone giant cell sarcoma 10.1 TP53 H3-3B H3-3A
46 parameningeal embryonal rhabdomyosarcoma 10.1 TP53 MDM2
47 vulvar intraepithelial neoplasia 10.1 TP53 CDKN2A
48 uterine corpus endometrial carcinoma 10.1 TP53 PTEN IDH1
49 atypical teratoid rhabdoid tumor 10.1 TP53 H3-3A ATRX
50 colon leiomyoma 10.1 H3-3B H3-3A

Graphical network of the top 20 diseases related to Adult Astrocytic Tumour:



Diseases related to Adult Astrocytic Tumour
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Symptoms & Phenotypes for Adult Astrocytic Tumour

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MGI Mouse Phenotypes related to Adult Astrocytic Tumour:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 neoplasm MP:0002006 9.43 CDKN2A IDH2 MDM2 PDGFRA PTEN TP53
2 pigmentation MP:0001186 9.02 CDKN2A MDM2 PDGFRA PTEN TP53
Sources

Drugs & Therapeutics for Adult Astrocytic Tumour

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Drugs for Adult Astrocytic Tumour (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 6)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Parathyroid hormone Approved, Investigational Phase 1 9002-64-6
2
Entinostat Investigational Phase 1 209783-80-2
3 Vaccines Phase 1
4 Liver Extracts Phase 1
5 Cola Phase 1
6 Histone Deacetylase Inhibitors Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Recurrent GBM Stem Cell Tumor Amplified RNA Immunotherapy Trial Completed NCT00890032 Phase 1
2 A Phase I Study of an Oral Histone Deacetylase Inhibitor, MS-275, in Refractory Solid Tumors and Lymphomas Completed NCT00020579 Phase 1 entinostat
3 A Population Based Study of Genetic Predisposition and Gene-Environment Interactions in Cancer in East Anglia, Trent and West Midlands Unknown status NCT00757614
4 A Pharmacokinetic Participation Questionnaire Study Completed NCT00890435

Search NIH Clinical Center for Adult Astrocytic Tumour

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Genetic Tests for Adult Astrocytic Tumour

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Anatomical Context for Adult Astrocytic Tumour

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MalaCards organs/tissues related to Adult Astrocytic Tumour:

40
Liver, Brain
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Publications for Adult Astrocytic Tumour

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Articles related to Adult Astrocytic Tumour:

(show all 12)
# Title Authors PMID Year
1
Total copy number variation as a prognostic factor in adult astrocytoma subtypes. 61
31177992 2019
2
Expression of nerve growth factor and brain-derived neurotrophic factor in astrocytomas. 61
29391888 2018
3
Treatment Outcomes and Prognostic Factors in Adult Astrocytoma: In North East of Iran. 61
27822343 2016
4
Genomic discoveries in adult astrocytoma. 61
25616158 2015
5
ATRX and IDH1-R132H immunohistochemistry with subsequent copy number analysis and IDH sequencing as a basis for an "integrated" diagnostic approach for adult astrocytoma, oligodendroglioma and glioblastoma. 61
25427834 2015
6
Polymorphisms in the matrix metalloproteinase-1, 3, and 9 promoters and susceptibility to adult astrocytoma in northern China. 61
17502998 2007
7
Association between the functional polymorphism in the matrix metalloproteinase-7 promoter and susceptibility to adult astrocytoma. 61
16956593 2006
8
Patterns of practice and survival in a retrospective analysis of 1722 adult astrocytoma patients treated between 1985 and 2001 in 12 Italian radiation oncology centers. 61
16682131 2006
9
Somatic induction of Pten loss in a preclinical astrocytoma model reveals major roles in disease progression and avenues for target discovery and validation. 61
15958561 2005
10
Multiple angiotensin receptor subtypes in normal and tumor astrocytes in vitro. 61
12203396 2002
11
A review of astrocytoma in childhood. 61
2518326 1989
12
A study of glial fibrillary acidic protein (GFAP) in childhood brain tumours. 61
6339423 1983
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Variations for Adult Astrocytic Tumour

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Expression for Adult Astrocytic Tumour

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Search GEO for disease gene expression data for Adult Astrocytic Tumour.
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Pathways for Adult Astrocytic Tumour

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Pathways related to Adult Astrocytic Tumour according to GeneCards Suite gene sharing:

(show all 26)
# Super pathways Score Top Affiliating Genes
1
Endometrial cancer 36
Show member pathways
 12.76 TP53 PTEN PDGFRA MDM2 CDKN2A
2
Pathways in cancer 36
12.72 TP53 PTEN PDGFRA MDM2 CDKN2A
3
Glioma 36
Show member pathways
 12.49 TP53 PTEN PDGFRA MDM2 CDKN2A
4
ErbB signaling pathway 36 1
Show member pathways
 12.48 TP53 PTEN PDGFRA MDM2
5
Shigellosis 36
12.3 TP53 MDM2 H3-3B H3-3A
6
MicroRNAs in cancer 36
12.29 TP53 PTEN PDGFRA MDM2 CDKN2A
7
DNA Damage Response 1
Show member pathways
 12.24 TP53 PTEN MDM2 CDKN2A
8
Transcriptional misregulation in cancer 36
12.13 TP53 MDM2 H3-3B H3-3A
9
MAPK Signaling: Mitogen Stimulation Pathway 64
Show member pathways
 12.11 TP53 PTEN PDGFRA MDM2
10
Cellular senescence (KEGG) 36
11.95 TP53 PTEN MDM2 CDKN2A
11
DNA Damage Response (only ATM dependent) 1
11.73 TP53 PTEN MDM2 CDKN2A
12
Senescence and Autophagy in Cancer 1
11.65 TP53 PTEN MDM2 CDKN2A
13
Regulation of TP53 Expression and Degradation 65
Show member pathways
 11.63 TP53 MDM2 CDKN2A
14
Platinum drug resistance 36
11.62 TP53 MDM2 CDKN2A
15
Bladder cancer 36 1
11.62 TP53 MDM2 CDKN2A
16
Pathways Affected in Adenoid Cystic Carcinoma 1
11.55 TP53 PTEN ATRX
17
HIF1Alpha Pathway 63
11.44 TP53 MDM2 CDKN2A
18
Copper homeostasis 1
11.43 TP53 PTEN MDM2
19
Glioblastoma Multiforme 63
11.4 TP53 PTEN PDGFRA MDM2 CDKN2A
20
Photodynamic therapy-induced AP-1 survival signaling. 1
11.39 TP53 PDGFRA CDKN2A
21
Integrated Cancer Pathway 1
11.32 TP53 PTEN MDM2
22
Oncogene Induced Senescence 65
11.11 TP53 MDM2 CDKN2A
23
Central carbon metabolism in cancer 36
10.87 TP53 PTEN PDGFRA IDH2 IDH1
24
TP53 Network 1
Show member pathways
 10.78 TP53 MDM2 CDKN2A
25
Cytosine methylation 1
Show member pathways
 10.73 IDH2 IDH1
26
Inhibition of Ribosome Biogenesis by p14(ARF) 63
10.67 TP53 MDM2 CDKN2A
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GO Terms for Adult Astrocytic Tumour

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Cellular components related to Adult Astrocytic Tumour according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nuclear body GO:0016604 9.62 TP53 MDM2 CDKN2A ATRX
2 PML body GO:0016605 9.43 TP53 PTEN ATRX
3 Barr body GO:0001740 9.16 H3-3B H3-3A
4 nuclear chromosome GO:0000228 9.13 H3-3B H3-3A ATRX
5 protein-containing complex GO:0032991 9.1 TP53 PDGFRA MDM2 H3-3B H3-3A CDKN2A

Biological processes related to Adult Astrocytic Tumour according to GeneCards Suite gene sharing:

(show all 22)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of transcription, DNA-templated GO:0045892 9.93 TP53 PRAMEF9 PRAMEF25 MDM2 CDKN2A
2 positive regulation of cell proliferation GO:0008284 9.91 PTEN PRAMEF9 PRAMEF25 PDGFRA MDM2
3 negative regulation of apoptotic process GO:0043066 9.89 TP53 PTEN PRAMEF9 PRAMEF25 MDM2
4 nucleosome assembly GO:0006334 9.76 H3-3B H3-3A ATRX
5 muscle cell differentiation GO:0042692 9.61 H3-3B H3-3A
6 positive regulation of cardiac muscle cell apoptotic process GO:0010666 9.6 TP53 PTEN
7 2-oxoglutarate metabolic process GO:0006103 9.59 IDH2 IDH1
8 replicative senescence GO:0090399 9.58 TP53 CDKN2A
9 DNA damage response, signal transduction by p53 class mediator GO:0030330 9.57 TP53 ATRX
10 cardiac septum morphogenesis GO:0060411 9.56 TP53 MDM2
11 amyloid fibril formation GO:1990000 9.55 MDM2 CDKN2A
12 NADP metabolic process GO:0006739 9.52 IDH2 IDH1
13 cellular response to UV-C GO:0071494 9.48 TP53 MDM2
14 isocitrate metabolic process GO:0006102 9.46 IDH2 IDH1
15 pericentric heterochromatin assembly GO:0031508 9.43 H3-3B H3-3A
16 regulation of centromere complex assembly GO:0090230 9.4 H3-3B H3-3A
17 cellular response to actinomycin D GO:0072717 9.37 TP53 MDM2
18 negative regulation of chromosome condensation GO:1902340 9.32 H3-3B H3-3A
19 telomeric heterochromatin assembly GO:0031509 9.26 H3-3B H3-3A
20 glyoxylate cycle GO:0006097 9.16 IDH2 IDH1
21 DNA replication-independent nucleosome assembly GO:0006336 9.13 H3-3B H3-3A ATRX
22 multicellular organism growth GO:0035264 8.92 TP53 H3-3B H3-3A ATRX

Molecular functions related to Adult Astrocytic Tumour according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 p53 binding GO:0002039 9.43 TP53 MDM2 CDKN2A
2 SUMO transferase activity GO:0019789 9.4 MDM2 CDKN2A
3 platelet-derived growth factor receptor binding GO:0005161 9.37 PTEN PDGFRA
4 disordered domain specific binding GO:0097718 9.33 TP53 MDM2 CDKN2A
5 MDM2/MDM4 family protein binding GO:0097371 9.32 TP53 CDKN2A
6 isocitrate dehydrogenase (NADP+) activity GO:0004450 8.96 IDH2 IDH1
7 isocitrate dehydrogenase activity GO:0004448 8.62 IDH2 IDH1
Sources

Sources for Adult Astrocytic Tumour

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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