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MCID: ADL053
MIFTS: 35

Adult Astrocytic Tumour

Categories: Cancer diseases, Neuronal diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Adult Astrocytic Tumour

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MalaCards integrated aliases for Adult Astrocytic Tumour:

Name: Adult Astrocytic Tumour 12 15
Adult Astrocytic Tumors 74
Adult Astrocytoma 12

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Neuronal diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:3076
NCIt 51 C7049
UMLS 74 C1332183
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Summaries for Adult Astrocytic Tumour

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MalaCards based summary : Adult Astrocytic Tumour, also known as adult astrocytic tumors, is related to oligodendroglioma and glioblastoma. An important gene associated with Adult Astrocytic Tumour is ATRX (ATRX Chromatin Remodeler), and among its related pathways/superpathways are Degradation of the extracellular matrix and G-protein signaling Regulation of p38 and JNK signaling mediated by G-proteins. The drugs Parathyroid hormone and Entinostat have been mentioned in the context of this disorder. Affiliated tissues include brain, liver and bone, and related phenotypes are neoplasm and vision/eye

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Related Diseases for Adult Astrocytic Tumour

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Diseases related to Adult Astrocytic Tumour via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 82)
# Related Disease Score Top Affiliating Genes
1 oligodendroglioma 29.6 IDH1 IDH2 PTEN
2 glioblastoma 29.2 H3F3A IDH1 IDH2 PTEN
3 interval angle-closure glaucoma 10.4 IDH1 IDH2
4 adult oligodendroglioma 10.4 IDH1 IDH2
5 enchondroma 10.4 IDH1 IDH2
6 intracranial chondrosarcoma 10.4 IDH1 IDH2
7 cytogenetically normal acute myeloid leukemia 10.3 IDH1 IDH2
8 chondroblastic osteosarcoma 10.3 IDH1 IDH2
9 multiple enchondromatosis, maffucci type 10.3 IDH1 IDH2
10 intraductal papilloma 10.3 IDH1 IDH2
11 pilocytic astrocytoma of cerebellum 10.3 IDH1 IDH2
12 spindle cell hemangioma 10.3 IDH1 IDH2
13 periosteal chondrosarcoma 10.3 IDH1 IDH2
14 superior limbic keratoconjunctivitis 10.3 MMP1 MMP3
15 diffuse infiltrative lymphocytosis syndrome 10.3 IDH1 IDH2
16 tendinopathy 10.3 MMP1 MMP3
17 drug-induced mental disorder 10.3 IDH1 IDH2
18 drug psychosis 10.3 IDH1 IDH2
19 undifferentiated pleomorphic sarcoma 10.2 IDH1 IDH2
20 conjunctivochalasis 10.2 MMP1 MMP3
21 nodular ganglioneuroblastoma 10.2 ATRX BDNF
22 gemistocytic astrocytoma 10.2 IDH2 PTEN
23 bone giant cell sarcoma 10.2 H3F3A H3F3B
24 malignant giant cell tumor 10.2 H3F3A H3F3B
25 glioma susceptibility 1 10.1 H3F3A IDH1 IDH2
26 coronary artery aneurysm 10.1 MMP1 MMP3 MMP7
27 brain stem cancer 10.1 H3F3A H3F3B
28 cannabis abuse 10.1 BDNF NGF
29 astrocytoma 10.1
30 corneal edema 10.1 MMP1 MMP3
31 diffuse intrinsic pontine glioma 10.1 H3F3A H3F3B
32 gliomatosis cerebri 10.1 IDH1 PTEN
33 neuropathy, hereditary sensory and autonomic, type v 10.1 BDNF NGF
34 focal myositis 10.1 MMP7 MMP9
35 rheumatoid nodulosis 10.0 MMP3 MMP9
36 senile ectropion 10.0 MMP7 MMP9
37 nervous system cancer 10.0 IDH1 IDH2 PTEN
38 chondroblastoma 10.0 H3F3A H3F3B
39 brain glioblastoma multiforme 10.0 MMP7 MMP9
40 blepharochalasis 10.0 MMP3 MMP9
41 gingival hypertrophy 10.0 MMP3 MMP9
42 chronic actinic dermatitis 10.0 MMP1 MMP9
43 tendinosis 10.0 BDNF MMP1 MMP3
44 spinal cord astrocytoma 10.0 H3F3A H3F3B IDH1
45 fibrillary astrocytoma 10.0 ATRX H3F3A IDH1 IDH2
46 pediatric multiple sclerosis 10.0 MMP7 MMP9
47 epidermolysis bullosa dystrophica 10.0 MMP1 MMP3
48 chromoblastomycosis 10.0 MMP1 MMP9
49 chondrosarcoma 10.0 IDH1 IDH2 MMP1 MMP3
50 2-hydroxyglutaric aciduria 9.9 IDH1 IDH2

Graphical network of the top 20 diseases related to Adult Astrocytic Tumour:



Diseases related to Adult Astrocytic Tumour
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Symptoms & Phenotypes for Adult Astrocytic Tumour

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MGI Mouse Phenotypes related to Adult Astrocytic Tumour:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 neoplasm MP:0002006 9.35 IDH2 MMP1 MMP7 MMP9 PTEN
2 vision/eye MP:0005391 9.1 ATRX BDNF MMP7 MMP9 NGF PTEN
Sources

Drugs & Therapeutics for Adult Astrocytic Tumour

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Drugs for Adult Astrocytic Tumour (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Parathyroid hormone Approved, Investigational Phase 1 9002-64-6
2
Entinostat Investigational Phase 1 209783-80-2
3 Cola Phase 1
4 Histone Deacetylase Inhibitors Phase 1
5 Liver Extracts Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 MS-275 in Treating Patients With Advanced Solid Tumors or Lymphoma Completed NCT00020579 Phase 1 entinostat
2 Study of Genes and Environment in Patients With Cancer in East Anglia, Trent, or West Midlands Regions of the United Kingdom Unknown status NCT00757614
3 Decision Making About Participating in Pharmacokinetic Studies in Patients Enrolled in a Phase I Treatment Clinical Trial Completed NCT00890435

Search NIH Clinical Center for Adult Astrocytic Tumour

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Genetic Tests for Adult Astrocytic Tumour

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Anatomical Context for Adult Astrocytic Tumour

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MalaCards organs/tissues related to Adult Astrocytic Tumour:

42
Brain, Liver, Bone, Spinal Cord, Myeloid, Cerebellum
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Publications for Adult Astrocytic Tumour

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Articles related to Adult Astrocytic Tumour:

# Title Authors Year
1
p53 protein alterations in adult astrocytic tumors and oligodendrogliomas. ( 15269478 )
2004
2
Prognostic scoring in adult astrocytic tumors using patient age, histopathological grade, and DNA histogram type. ( 8169628 )
1994
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Variations for Adult Astrocytic Tumour

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Expression for Adult Astrocytic Tumour

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Search GEO for disease gene expression data for Adult Astrocytic Tumour.
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Pathways for Adult Astrocytic Tumour

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Pathways related to Adult Astrocytic Tumour according to GeneCards Suite gene sharing:

(show all 17)
# Super pathways Score Top Affiliating Genes
1
Degradation of the extracellular matrix 67
Show member pathways
 12.48 MMP1 MMP3 MMP7 MMP9
2
G-protein signaling Regulation of p38 and JNK signaling mediated by G-proteins 23
Show member pathways
 11.95 MMP1 MMP3 MMP7 MMP9
3
Transcriptional misregulation in cancer 38
11.94 H3F3A H3F3B MMP3 MMP9
4
Colorectal Cancer Metastasis 65
11.93 MMP1 MMP7 MMP9
5
Microglia Activation During Neuroinflammation: Overview 66
Show member pathways
 11.79 MMP3 MMP7 MMP9
6
Interleukin-4 and 13 signaling 67
11.73 MMP1 MMP3 MMP9
7
Angiogenesis (CST) 4
11.58 MMP3 MMP7 MMP9
8
Matrix Metalloproteinases 1
Show member pathways
 11.55 MMP1 MMP3 MMP7 MMP9
9
Microglia Activation During Neuroinflammation: Microglia Polarization 66
11.46 BDNF MMP3 MMP9
10
Photodynamic therapy-induced NF-kB survival signaling 1
Show member pathways
 11.38 MMP1 MMP3 MMP9
11
Validated transcriptional targets of AP1 family members Fra1 and Fra2 1
11.1 MMP1 MMP9
12
Cell adhesion_Cell-matrix glycoconjugates 23
11.09 MMP1 MMP3 MMP9
13
Cell cycle_Chromosome condensation in prometaphase 23
11.08 H3F3A H3F3B
14
p75(NTR)-mediated signaling 1
Show member pathways
 11.08 BDNF MMP3 MMP7 NGF
15
Cell adhesion_ECM remodeling 23
10.71 MMP1 MMP3 MMP7 MMP9
16
Cytosine methylation 1
Show member pathways
 10.59 IDH1 IDH2
17
Syndecan-1-mediated signaling events 1
10.56 MMP1 MMP7 MMP9
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GO Terms for Adult Astrocytic Tumour

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Cellular components related to Adult Astrocytic Tumour according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular matrix GO:0031012 9.56 MMP1 MMP3 MMP7 MMP9
2 nuclear chromosome, telomeric region GO:0000784 9.5 ATRX H3F3A H3F3B
3 extracellular region GO:0005576 9.32 BDNF H3F3A H3F3B IDH1 MMP1 MMP3
4 Barr body GO:0001740 9.16 H3F3A H3F3B
5 nuclear chromosome GO:0000228 9.13 ATRX H3F3A H3F3B

Biological processes related to Adult Astrocytic Tumour according to GeneCards Suite gene sharing:

(show all 30)
# Name GO ID Score Top Affiliating Genes
1 nucleosome assembly GO:0006334 9.75 ATRX H3F3A H3F3B
2 multicellular organism growth GO:0035264 9.73 ATRX H3F3A H3F3B
3 memory GO:0007613 9.71 BDNF NGF PTEN
4 oogenesis GO:0048477 9.65 H3F3A H3F3B
5 tricarboxylic acid cycle GO:0006099 9.64 IDH1 IDH2
6 nucleus organization GO:0006997 9.64 H3F3A H3F3B
7 positive regulation of DNA binding GO:0043388 9.63 MMP9 NGF
8 peripheral nervous system development GO:0007422 9.63 BDNF NGF
9 regulation of neuron differentiation GO:0045664 9.62 BDNF NGF
10 telomere organization GO:0032200 9.62 H3F3A H3F3B
11 2-oxoglutarate metabolic process GO:0006103 9.61 IDH1 IDH2
12 neurotrophin TRK receptor signaling pathway GO:0048011 9.61 BDNF NGF
13 embryo implantation GO:0007566 9.61 H3F3A H3F3B MMP9
14 muscle cell differentiation GO:0042692 9.6 H3F3A H3F3B
15 positive regulation of protein oligomerization GO:0032461 9.59 MMP1 MMP3
16 nerve development GO:0021675 9.58 BDNF NGF
17 nerve growth factor signaling pathway GO:0038180 9.57 BDNF NGF
18 NADP metabolic process GO:0006739 9.55 IDH1 IDH2
19 positive regulation of collateral sprouting GO:0048672 9.52 BDNF NGF
20 positive regulation of receptor binding GO:1900122 9.51 BDNF MMP9
21 isocitrate metabolic process GO:0006102 9.49 IDH1 IDH2
22 regulation of neuroinflammatory response GO:0150077 9.48 MMP3 MMP9
23 pericentric heterochromatin assembly GO:0031508 9.46 H3F3A H3F3B
24 regulation of centromere complex assembly GO:0090230 9.4 H3F3A H3F3B
25 glyoxylate cycle GO:0006097 9.37 IDH1 IDH2
26 DNA replication-independent nucleosome assembly GO:0006336 9.33 ATRX H3F3A H3F3B
27 negative regulation of chromosome condensation GO:1902340 9.32 H3F3A H3F3B
28 telomeric heterochromatin assembly GO:0031509 9.26 H3F3A H3F3B
29 extracellular matrix disassembly GO:0022617 9.26 MMP1 MMP3 MMP7 MMP9
30 collagen catabolic process GO:0030574 8.92 MMP1 MMP3 MMP7 MMP9

Molecular functions related to Adult Astrocytic Tumour according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hydrolase activity GO:0016787 9.88 ATRX MMP1 MMP3 MMP7 MMP9 PTEN
2 peptidase activity GO:0008233 9.76 MMP1 MMP3 MMP7 MMP9
3 serine-type endopeptidase activity GO:0004252 9.62 MMP1 MMP3 MMP7 MMP9
4 metallopeptidase activity GO:0008237 9.56 MMP1 MMP3 MMP7 MMP9
5 endopeptidase activity GO:0004175 9.54 MMP1 MMP3 MMP9
6 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GO:0016616 9.48 IDH1 IDH2
7 RNA polymerase II core promoter sequence-specific DNA binding GO:0000979 9.43 H3F3A H3F3B
8 isocitrate dehydrogenase (NADP+) activity GO:0004450 9.16 IDH1 IDH2
9 isocitrate dehydrogenase activity GO:0004448 8.96 IDH1 IDH2
10 metalloendopeptidase activity GO:0004222 8.92 MMP1 MMP3 MMP7 MMP9
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Sources for Adult Astrocytic Tumour

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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