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MCID: ADL053
MIFTS: 31

Adult Astrocytic Tumour

Categories: Bone diseases, Cancer diseases, Neuronal diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Adult Astrocytic Tumour

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MalaCards integrated aliases for Adult Astrocytic Tumour:

Name: Adult Astrocytic Tumour 12 15
Adult Astrocytic Tumors 71
Adult Astrocytoma 12

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Bone diseases Neuronal diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:3076
NCIt 49 C7049
UMLS 71 C1332183
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Summaries for Adult Astrocytic Tumour

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MalaCards based summary : Adult Astrocytic Tumour, also known as adult astrocytic tumors, is related to glial tumor and high-grade astrocytoma. An important gene associated with Adult Astrocytic Tumour is LUC7L2 (LUC7 Like 2, Pre-MRNA Splicing Factor), and among its related pathways/superpathways are MicroRNAs in cancer and DNA Damage Response (only ATM dependent). The drugs Parathyroid hormone and Entinostat have been mentioned in the context of this disorder. Affiliated tissues include brain, breast and bone.

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Related Diseases for Adult Astrocytic Tumour

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Diseases related to Adult Astrocytic Tumour via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 170)
# Related Disease Score Top Affiliating Genes
1 glial tumor 30.2 PTEN IDH1
2 high-grade astrocytoma 30.1 PTEN IDH1
3 glioma susceptibility 1 28.2 TP53 PTEN PDGFRA IDH2 IDH1 H3-3A
4 oligodendroglioma 28.1 TP53 PTEN PDGFRA IDH2 IDH1 CDKN2A
5 glioblastoma multiforme 27.8 TP53 PTEN PDGFRA IDH2 IDH1 H3-3B
6 enchondroma 10.5 IDH2 IDH1
7 pediatric meningioma 10.5 LUC7L2 KIAA1549
8 cytogenetically normal acute myeloid leukemia 10.5 IDH2 IDH1
9 intracranial chondrosarcoma 10.5 IDH2 IDH1
10 central nervous system rhabdomyosarcoma 10.5 IDH2 IDH1
11 periosteal chondrosarcoma 10.5 IDH2 IDH1
12 juxtacortical chondroma 10.5 IDH2 IDH1
13 temporal lobe neoplasm 10.4 IDH1 ATRX
14 diffuse intrinsic pontine glioma 10.4 H3-3B H3-3A
15 interval angle-closure glaucoma 10.4 IDH2 IDH1
16 malignant giant cell tumor 10.4 H3-3B H3-3A
17 frontal lobe neoplasm 10.4 TP53 IDH1
18 telangiectatic osteogenic sarcoma 10.4 H3-3B H3-3A
19 spinal cancer 10.4 LUC7L2 KIAA1549 IDH1
20 dysembryoplastic neuroepithelial tumor 10.4 LUC7L2 KIAA1549 IDH1
21 clear cell ependymoma 10.4 KIAA1549 IDH1
22 enchondromatosis, multiple, ollier type 10.3 IDH2 IDH1 ATRX
23 gliofibroma 10.3 TP53 IDH1
24 spinal cord ependymoma 10.3 LUC7L2 KIAA1549
25 colon leiomyoma 10.3 H3-3B H3-3A
26 breast hemangioma 10.3 TP53 IDH2 IDH1
27 intraductal breast neoplasm 10.3 TP53 IDH2 IDH1
28 thoracic benign neoplasm 10.3 TP53 IDH2 IDH1
29 breast benign neoplasm 10.3 TP53 IDH2 IDH1
30 astrocytoma 10.2
31 undifferentiated pleomorphic sarcoma 10.2 PDGFRA IDH2 IDH1
32 breast duct papilloma 10.2 PTEN IDH2 IDH1
33 brain glioma 10.2 TP53 IDH2 IDH1
34 gangliocytoma 10.2 PTEN KIAA1549
35 systemic mastocytosis 10.2 PDGFRA IDH2 IDH1
36 bone giant cell sarcoma 10.2 TP53 H3-3B H3-3A
37 anaplastic oligodendroglioma 10.2 IDH2 CDKN2A
38 brain stem cancer 10.2 PDGFRA H3-3B H3-3A
39 cerebellar astrocytoma 10.1 KIAA1549 IDH2 IDH1 H3-3B
40 uterine corpus endometrial carcinoma 10.1 TP53 PTEN IDH1
41 vulvar intraepithelial neoplasia 10.1 TP53 CDKN2A
42 thyroid gland anaplastic carcinoma 10.1 TP53 PTEN
43 juvenile astrocytoma 10.1 TP53 LUC7L2 KIAA1549 IDH1
44 ovarian seromucinous carcinoma 10.1 TP53 CDKN2A
45 esophagus verrucous carcinoma 10.1 TP53 CDKN2A
46 chronic leukemia 10.1 PTEN PDGFRA LUC7L2
47 spinal cord astrocytoma 10.1 KIAA1549 IDH1 H3-3B H3-3A
48 pilocytic astrocytoma of cerebellum 10.1 KIAA1549 IDH1 H3-3B H3-3A
49 malignant ependymoma 10.1 KIAA1549 IDH1 H3-3B H3-3A
50 spitz nevus 10.1 TP53 CDKN2A

Graphical network of the top 20 diseases related to Adult Astrocytic Tumour:



Diseases related to Adult Astrocytic Tumour
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Symptoms & Phenotypes for Adult Astrocytic Tumour

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Drugs & Therapeutics for Adult Astrocytic Tumour

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Drugs for Adult Astrocytic Tumour (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 6)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Parathyroid hormone Approved, Investigational Phase 1 9002-64-6
2
Entinostat Investigational Phase 1 209783-80-2
3 Liver Extracts Phase 1
4 Histone Deacetylase Inhibitors Phase 1
5 Cola Phase 1
6 Vaccines Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Phase I Study of an Oral Histone Deacetylase Inhibitor, MS-275, in Refractory Solid Tumors and Lymphomas Completed NCT00020579 Phase 1 entinostat
2 Recurrent GBM Stem Cell Tumor Amplified RNA Immunotherapy Trial Completed NCT00890032 Phase 1
3 A Population Based Study of Genetic Predisposition and Gene-Environment Interactions in Cancer in East Anglia, Trent and West Midlands Unknown status NCT00757614
4 A Pharmacokinetic Participation Questionnaire Study Completed NCT00890435

Search NIH Clinical Center for Adult Astrocytic Tumour

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Genetic Tests for Adult Astrocytic Tumour

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Anatomical Context for Adult Astrocytic Tumour

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MalaCards organs/tissues related to Adult Astrocytic Tumour:

40
Brain, Breast, Bone, Spinal Cord, Ovary, Cerebellum, Liver
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Publications for Adult Astrocytic Tumour

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Articles related to Adult Astrocytic Tumour:

(show all 12)
# Title Authors PMID Year
1
Total copy number variation as a prognostic factor in adult astrocytoma subtypes. 61
31177992 2019
2
Expression of nerve growth factor and brain-derived neurotrophic factor in astrocytomas. 61
29391888 2018
3
Treatment Outcomes and Prognostic Factors in Adult Astrocytoma: In North East of Iran. 61
27822343 2016
4
Genomic discoveries in adult astrocytoma. 61
25616158 2015
5
ATRX and IDH1-R132H immunohistochemistry with subsequent copy number analysis and IDH sequencing as a basis for an "integrated" diagnostic approach for adult astrocytoma, oligodendroglioma and glioblastoma. 61
25427834 2015
6
Polymorphisms in the matrix metalloproteinase-1, 3, and 9 promoters and susceptibility to adult astrocytoma in northern China. 61
17502998 2007
7
Association between the functional polymorphism in the matrix metalloproteinase-7 promoter and susceptibility to adult astrocytoma. 61
16956593 2006
8
Patterns of practice and survival in a retrospective analysis of 1722 adult astrocytoma patients treated between 1985 and 2001 in 12 Italian radiation oncology centers. 61
16682131 2006
9
Somatic induction of Pten loss in a preclinical astrocytoma model reveals major roles in disease progression and avenues for target discovery and validation. 61
15958561 2005
10
Multiple angiotensin receptor subtypes in normal and tumor astrocytes in vitro. 61
12203396 2002
11
A review of astrocytoma in childhood. 61
2518326 1989
12
A study of glial fibrillary acidic protein (GFAP) in childhood brain tumours. 61
6339423 1983
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Variations for Adult Astrocytic Tumour

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Expression for Adult Astrocytic Tumour

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Search GEO for disease gene expression data for Adult Astrocytic Tumour.
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Pathways for Adult Astrocytic Tumour

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Pathways related to Adult Astrocytic Tumour according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
MicroRNAs in cancer 36
12.16 TP53 PTEN PDGFRA CDKN2A
2
DNA Damage Response (only ATM dependent) 1
11.67 TP53 PTEN CDKN2A
3
Senescence and Autophagy in Cancer 1
11.61 TP53 PTEN CDKN2A
4
Glioblastoma Multiforme 63
11.3 TP53 PTEN PDGFRA CDKN2A
5
Pathways Affected in Adenoid Cystic Carcinoma 1
11.25 TP53 PTEN ATRX
6
Photodynamic therapy-induced AP-1 survival signaling. 1
11.04 TP53 PDGFRA CDKN2A
7
Central carbon metabolism in cancer 36
10.76 TP53 PTEN PDGFRA IDH1
8
Cytosine methylation 1
Show member pathways
 10.44 IDH2 IDH1
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GO Terms for Adult Astrocytic Tumour

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Cellular components related to Adult Astrocytic Tumour according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nucleus GO:0005634 10.18 ZNF337 TP53 PUF60 PTEN PDGFRA LUC7L2
2 nucleoplasm GO:0005654 9.85 TP53 PUF60 PTEN PDGFRA LUC7L2 KMT5C
3 nuclear chromosome, telomeric region GO:0000784 9.61 H3-3B H3-3A ATRX
4 PML body GO:0016605 9.43 TP53 PTEN ATRX
5 condensed nuclear chromosome, centromeric region GO:0000780 9.37 KMT5C ATRX
6 pericentric heterochromatin GO:0005721 9.32 KMT5C ATRX
7 Barr body GO:0001740 8.96 H3-3B H3-3A
8 nuclear chromosome GO:0000228 8.8 H3-3B H3-3A ATRX

Biological processes related to Adult Astrocytic Tumour according to GeneCards Suite gene sharing:

(show all 16)
# Name GO ID Score Top Affiliating Genes
1 cell proliferation GO:0008283 9.76 TP53 PTEN H3-3B H3-3A
2 nucleosome assembly GO:0006334 9.7 H3-3B H3-3A ATRX
3 positive regulation of cardiac muscle cell apoptotic process GO:0010666 9.56 TP53 PTEN
4 muscle cell differentiation GO:0042692 9.55 H3-3B H3-3A
5 2-oxoglutarate metabolic process GO:0006103 9.54 IDH2 IDH1
6 DNA damage response, signal transduction by p53 class mediator GO:0030330 9.51 TP53 ATRX
7 replicative senescence GO:0090399 9.49 TP53 CDKN2A
8 NADP metabolic process GO:0006739 9.48 IDH2 IDH1
9 isocitrate metabolic process GO:0006102 9.43 IDH2 IDH1
10 pericentric heterochromatin assembly GO:0031508 9.4 H3-3B H3-3A
11 regulation of centromere complex assembly GO:0090230 9.37 H3-3B H3-3A
12 negative regulation of chromosome condensation GO:1902340 9.32 H3-3B H3-3A
13 telomeric heterochromatin assembly GO:0031509 9.26 H3-3B H3-3A
14 glyoxylate cycle GO:0006097 9.16 IDH2 IDH1
15 DNA replication-independent nucleosome assembly GO:0006336 9.13 H3-3B H3-3A ATRX
16 multicellular organism growth GO:0035264 8.92 TP53 H3-3B H3-3A ATRX

Molecular functions related to Adult Astrocytic Tumour according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 RNA polymerase II distal enhancer sequence-specific DNA binding GO:0000980 9.33 TP53 H3-3B H3-3A
2 platelet-derived growth factor receptor binding GO:0005161 9.26 PTEN PDGFRA
3 isocitrate dehydrogenase (NADP+) activity GO:0004450 8.96 IDH2 IDH1
4 isocitrate dehydrogenase activity GO:0004448 8.62 IDH2 IDH1
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Sources for Adult Astrocytic Tumour

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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