Adult Astrocytic Tumour disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Adult Astrocytic Tumour

MalaCards integrated aliases for Adult Astrocytic Tumour:

Name: Adult Astrocytic Tumour ¹² ¹⁵

Adult Astrocytic Tumors ⁷³

Adult Astrocytoma ¹²

Classifications:

MalaCards categories:
Global: Cancer diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:3076

NCIt ⁵⁰ C7049

UMLS ⁷³ C1332183

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Summaries for Adult Astrocytic Tumour

MalaCards based summary : Adult Astrocytic Tumour, also known as adult astrocytic tumors, is related to oligodendroglioma and glioblastoma. An important gene associated with Adult Astrocytic Tumour is ATRX (ATRX, Chromatin Remodeler), and among its related pathways/superpathways are Degradation of the extracellular matrix and Transcriptional misregulation in cancer. The drugs Entinostat and Histone Deacetylase Inhibitors have been mentioned in the context of this disorder. Affiliated tissues include liver, and related phenotypes are neoplasm and vision/eye

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Related Diseases for Adult Astrocytic Tumour

Diseases related to Adult Astrocytic Tumour via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 75)

#	Related Disease	Score	Top Affiliating Genes
1	oligodendroglioma	29.4	IDH1 IDH2 PTEN
2	glioblastoma	28.7	H3F3A IDH1 IDH2 PTEN
3	interval angle-closure glaucoma	10.8	IDH1 IDH2
4	adult oligodendroglioma	10.8	IDH1 IDH2
5	enchondroma	10.8	IDH1 IDH2
6	intracranial chondrosarcoma	10.7	IDH1 IDH2
7	cytogenetically normal acute myeloid leukemia	10.7	IDH1 IDH2
8	intraductal papilloma	10.7	IDH1 IDH2
9	multiple enchondromatosis, maffucci type	10.7	IDH1 IDH2
10	pilocytic astrocytoma of cerebellum	10.7	IDH1 IDH2
11	spindle cell hemangioma	10.7	IDH1 IDH2
12	periosteal chondrosarcoma	10.6	IDH1 IDH2
13	superior limbic keratoconjunctivitis	10.6	MMP1 MMP3
14	undifferentiated pleomorphic sarcoma	10.6	IDH1 IDH2
15	drug-induced mental disorder	10.5	IDH1 IDH2
16	drug psychosis	10.5	IDH1 IDH2
17	nodular ganglioneuroblastoma	10.4	ATRX BDNF
18	conjunctivochalasis	10.4	MMP1 MMP3
19	bone giant cell sarcoma	10.4	H3F3A H3F3B
20	diffuse infiltrative lymphocytosis syndrome	10.4	IDH1 IDH2
21	malignant giant cell tumor	10.4	H3F3A H3F3B
22	gemistocytic astrocytoma	10.4	IDH2 PTEN
23	chondroblastic osteosarcoma	10.4	H3F3A IDH1 IDH2
24	glioma susceptibility 1	10.4	H3F3A IDH1 IDH2
25	brain stem cancer	10.3	H3F3A H3F3B
26	corneal edema	10.3	MMP1 MMP3
27	coronary artery aneurysm	10.2	MMP1 MMP3 MMP7
28	cannabis abuse	10.2	BDNF NGF
29	2-hydroxyglutaric aciduria	10.2	IDH1 IDH2
30	diffuse intrinsic pontine glioma	10.2	H3F3A H3F3B
31	gliomatosis cerebri	10.2	IDH1 PTEN
32	focal myositis	10.1	MMP7 MMP9
33	chondroblastoma	10.1	H3F3A H3F3B
34	rheumatoid nodulosis	10.1	MMP3 MMP9
35	senile ectropion	10.1	MMP7 MMP9
36	brain glioblastoma multiforme	10.1	MMP7 MMP9
37	spinal cord astrocytoma	10.1	H3F3A H3F3B IDH1
38	gingival hypertrophy	10.0	MMP3 MMP9
39	fibrillary astrocytoma	10.0	ATRX H3F3A IDH1 IDH2
40	blepharochalasis	10.0	MMP3 MMP9
41	pediatric multiple sclerosis	10.0	MMP7 MMP9
42	tendinosis	10.0	BDNF MMP1 MMP3
43	chronic actinic dermatitis	10.0	MMP1 MMP9
44	astrocytoma	9.9
45	epidermolysis bullosa dystrophica	9.9	MMP1 MMP3
46	traumatic brain injury	9.9	BDNF NGF
47	chromoblastomycosis	9.9	MMP1 MMP9
48	chondrosarcoma	9.9	IDH1 IDH2 MMP1 MMP3
49	breast papillary carcinoma	9.9	IDH1 IDH2
50	ocular dominance	9.9	BDNF NGF

Graphical network of the top 20 diseases related to Adult Astrocytic Tumour:

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Symptoms & Phenotypes for Adult Astrocytic Tumour

MGI Mouse Phenotypes related to Adult Astrocytic Tumour:

⁴⁶

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	neoplasm	MP:0002006	9.35	MMP7 MMP9 PTEN IDH2 MMP1
2	vision/eye	MP:0005391	9.1	MMP7 MMP9 NGF PTEN ATRX BDNF

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Drugs & Therapeutics for Adult Astrocytic Tumour

Drugs for Adult Astrocytic Tumour (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

#

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

1

Entinostat

Investigational

Phase 1

209783-80-2

2

Histone Deacetylase Inhibitors

Phase 1

3

Liver Extracts

Phase 1

4

Cola

Nutraceutical

Phase 1

Interventional clinical trials:

#	Name	Status	NCT ID	Phase	Drugs
1	MS-275 in Treating Patients With Advanced Solid Tumors or Lymphoma	Completed	NCT00020579	Phase 1	entinostat
2	Study of Genes and Environment in Patients With Cancer in East Anglia, Trent, or West Midlands Regions of the United Kingdom	Unknown status	NCT00757614
3	Decision Making About Participating in Pharmacokinetic Studies in Patients Enrolled in a Phase I Treatment Clinical Trial	Completed	NCT00890435

Search NIH Clinical Center for Adult Astrocytic Tumour

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Genetic Tests for Adult Astrocytic Tumour

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Anatomical Context for Adult Astrocytic Tumour

MalaCards organs/tissues related to Adult Astrocytic Tumour:

⁴¹

Liver

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Publications for Adult Astrocytic Tumour

Articles related to Adult Astrocytic Tumour:

#	Title	Authors	Year
1	p53-independent mechanisms regulate the P2-MDM2 promoter in adult astrocytic tumours. ( 18781178 )	Dimitriadi M....Collins V.P.	2008
2	Galectin-3 and galectin-3-binding site expression in human adult astrocytic tumours and related angiogenesis. ( 10476049 )	Gordower L....Camby I.	1999

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Genes for Adult Astrocytic Tumour

Genes related to Adult Astrocytic Tumour (0 elite genes):

(show all 12)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	ATRX	ATRX, Chromatin Remodeler	Protein Coding	14.89	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
2	IDH2	Isocitrate Dehydrogenase (NADP(+)) 2, Mitochondrial	Protein Coding	14.59	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
3	MMP7	Matrix Metallopeptidase 7	Protein Coding	14.36	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
4	IDH1	Isocitrate Dehydrogenase (NADP(+)) 1, Cytosolic	Protein Coding	14.29	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
5	MMP3	Matrix Metallopeptidase 3	Protein Coding	14.06	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
6	H3F3A	H3 Histone Family Member 3A	Protein Coding	14.04	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
7	MMP1	Matrix Metallopeptidase 1	Protein Coding	13.99	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
8	NGF	Nerve Growth Factor	Protein Coding	13.83	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
9	BDNF	Brain Derived Neurotrophic Factor	Protein Coding	13.65	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
10	PTEN	Phosphatase And Tensin Homolog	Protein Coding	13.47	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
11	MMP9	Matrix Metallopeptidase 9	Protein Coding	13.21	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
12	H3F3B	H3 Histone Family Member 3B	Protein Coding	4.04	DISEASES inferred ¹⁵

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Variations for Adult Astrocytic Tumour

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Expression for Adult Astrocytic Tumour

Search GEO for disease gene expression data for Adult Astrocytic Tumour.

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Pathways for Adult Astrocytic Tumour

Pathways related to Adult Astrocytic Tumour according to GeneCards Suite gene sharing:

(show all 14)

#	Super pathways	Score	Top Affiliating Genes
1	Degradation of the extracellular matrix ⁶⁶ Show member pathways Collagen degradation ⁶⁶ Extracellular matrix organization ⁶⁶	12.45	MMP1 MMP3 MMP7 MMP9
2	Transcriptional misregulation in cancer ³⁷	11.94	H3F3A H3F3B MMP3 MMP9
3	Colorectal Cancer Metastasis ⁶⁴	11.9	MMP1 MMP7 MMP9
4	Interleukin-4 and 13 signaling ⁶⁶	11.71	MMP1 MMP3 MMP9
5	Angiogenesis (CST) ⁴	11.56	MMP3 MMP7 MMP9
6	Matrix Metalloproteinases ¹ Show member pathways Activation of Matrix Metalloproteinases ⁶⁶ Inhibition of Matrix Metalloproteinases ⁶⁴	11.55	MMP1 MMP3 MMP7 MMP9
7	Photodynamic therapy-induced NF-kB survival signaling ¹ Show member pathways Immune response MIF-mediated glucocorticoid regulation ²²	11.38	MMP1 MMP3 MMP9
8	Cell adhesion_Cell-matrix glycoconjugates ²²	11.09	MMP1 MMP3 MMP9
9	p75(NTR)-mediated signaling ¹ Show member pathways Ceramide signalling ⁶⁶ NFG and proNGF binds to p75NTR ⁶⁶	11.08	BDNF MMP3 MMP7 NGF
10	Validated transcriptional targets of AP1 family members Fra1 and Fra2 ¹	11.07	MMP1 MMP9
11	Cell cycle_Chromosome condensation in prometaphase ²²	11.04	H3F3A H3F3B
12	Cell adhesion_ECM remodeling ²²	10.71	MMP1 MMP3 MMP7 MMP9
13	Cytosine methylation ¹ Show member pathways TET1,2,3 and TDG demethylate DNA ⁶⁶	10.57	IDH1 IDH2
14	Syndecan-1-mediated signaling events ¹	10.56	MMP1 MMP7 MMP9

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GO Terms for Adult Astrocytic Tumour

Cellular components related to Adult Astrocytic Tumour according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	extracellular matrix	GO:0031012	9.56	MMP1 MMP3 MMP7 MMP9
2	nuclear chromosome, telomeric region	GO:0000784	9.5	ATRX H3F3A H3F3B
3	extracellular region	GO:0005576	9.32	BDNF H3F3A H3F3B IDH1 MMP1 MMP3
4	Barr body	GO:0001740	9.16	H3F3A H3F3B
5	nuclear chromosome	GO:0000228	9.13	ATRX H3F3A H3F3B

Biological processes related to Adult Astrocytic Tumour according to GeneCards Suite gene sharing:

(show all 28)

#	Name	GO ID	Score	Top Affiliating Genes
1	nucleosome assembly	GO:0006334	9.73	ATRX H3F3A H3F3B
2	multicellular organism growth	GO:0035264	9.7	ATRX H3F3A H3F3B
3	memory	GO:0007613	9.69	BDNF NGF PTEN
4	oogenesis	GO:0048477	9.64	H3F3A H3F3B
5	tricarboxylic acid cycle	GO:0006099	9.63	IDH1 IDH2
6	regulation of neuron differentiation	GO:0045664	9.63	BDNF NGF
7	telomere organization	GO:0032200	9.62	H3F3A H3F3B
8	positive regulation of DNA binding	GO:0043388	9.62	MMP9 NGF
9	nucleus organization	GO:0006997	9.61	H3F3A H3F3B
10	peripheral nervous system development	GO:0007422	9.61	BDNF NGF
11	embryo implantation	GO:0007566	9.61	H3F3A H3F3B MMP9
12	2-oxoglutarate metabolic process	GO:0006103	9.6	IDH1 IDH2
13	muscle cell differentiation	GO:0042692	9.59	H3F3A H3F3B
14	positive regulation of protein oligomerization	GO:0032461	9.58	MMP1 MMP3
15	nerve development	GO:0021675	9.58	BDNF NGF
16	locomotion	GO:0040011	9.57	BDNF NGF
17	nerve growth factor signaling pathway	GO:0038180	9.55	BDNF NGF
18	positive regulation of collateral sprouting	GO:0048672	9.54	BDNF NGF
19	positive regulation of receptor binding	GO:1900122	9.49	BDNF MMP9
20	isocitrate metabolic process	GO:0006102	9.48	IDH1 IDH2
21	pericentric heterochromatin assembly	GO:0031508	9.46	H3F3A H3F3B
22	regulation of centromere complex assembly	GO:0090230	9.4	H3F3A H3F3B
23	telomeric heterochromatin assembly	GO:0031509	9.37	H3F3A H3F3B
24	DNA replication-independent nucleosome assembly	GO:0006336	9.33	ATRX H3F3A H3F3B
25	negative regulation of chromosome condensation	GO:1902340	9.32	H3F3A H3F3B
26	glyoxylate cycle	GO:0006097	9.26	IDH1 IDH2
27	extracellular matrix disassembly	GO:0022617	9.26	MMP1 MMP3 MMP7 MMP9
28	collagen catabolic process	GO:0030574	8.92	MMP1 MMP3 MMP7 MMP9

Molecular functions related to Adult Astrocytic Tumour according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	hydrolase activity	GO:0016787	9.88	ATRX MMP1 MMP3 MMP7 MMP9 PTEN
2	peptidase activity	GO:0008233	9.73	MMP1 MMP3 MMP7 MMP9
3	magnesium ion binding	GO:0000287	9.63	IDH1 IDH2 PTEN
4	serine-type endopeptidase activity	GO:0004252	9.62	MMP1 MMP3 MMP7 MMP9
5	metallopeptidase activity	GO:0008237	9.56	MMP1 MMP3 MMP7 MMP9
6	endopeptidase activity	GO:0004175	9.54	MMP1 MMP3 MMP9
7	isocitrate dehydrogenase activity	GO:0004448	9.16	IDH1 IDH2
8	isocitrate dehydrogenase (NADP+) activity	GO:0004450	8.96	IDH1 IDH2
9	metalloendopeptidase activity	GO:0004222	8.92	MMP1 MMP3 MMP7 MMP9

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Sources for Adult Astrocytic Tumour

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