MCID: ADL053
MIFTS: 33

Adult Astrocytic Tumour

Categories: Bone diseases, Cancer diseases, Neuronal diseases

Aliases & Classifications for Adult Astrocytic Tumour

MalaCards integrated aliases for Adult Astrocytic Tumour:

Name: Adult Astrocytic Tumour 12 15
Adult Astrocytic Tumors 71
Adult Astrocytoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:3076
NCIt 49 C7049
UMLS 71 C1332183

Summaries for Adult Astrocytic Tumour

MalaCards based summary : Adult Astrocytic Tumour, also known as adult astrocytic tumors, is related to glial tumor and high-grade astrocytoma. An important gene associated with Adult Astrocytic Tumour is LUC7L2 (LUC7 Like 2, Pre-MRNA Splicing Factor), and among its related pathways/superpathways are Endometrial cancer and Pathways in cancer. The drugs Parathyroid hormone and Entinostat have been mentioned in the context of this disorder. Affiliated tissues include bone, liver and brain, and related phenotypes are neoplasm and pigmentation

Related Diseases for Adult Astrocytic Tumour

Diseases related to Adult Astrocytic Tumour via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 211)
# Related Disease Score Top Affiliating Genes
1 glial tumor 30.3 PTEN IDH1
2 high-grade astrocytoma 30.1 PTEN IDH1
3 alpha-thalassemia 29.8 TP53 LUC7L2 ATRX
4 glioma susceptibility 1 28.4 TP53 PTEN PDGFRA MDM2 IDH2 IDH1
5 glioblastoma multiforme 28.3 TP53 PTEN PDGFRA MDM2 IDH2 IDH1
6 oligodendroglioma 28.0 TP53 PTEN PDGFRA MDM2 IDH2 IDH1
7 enchondroma 10.5 IDH2 IDH1
8 pediatric meningioma 10.5 LUC7L2 KIAA1549
9 breast intraductal papillomatosis 10.5 IDH2 IDH1
10 breast papillomatosis 10.5 IDH2 IDH1
11 adult brain stem glioma 10.5 IDH2 IDH1
12 cytogenetically normal acute myeloid leukemia 10.5 IDH2 IDH1
13 spinal cord astrocytoma 10.5 KIAA1549 IDH1
14 intracranial chondrosarcoma 10.5 IDH2 IDH1
15 pilocytic astrocytoma of cerebellum 10.5 KIAA1549 IDH1
16 temporal lobe neoplasm 10.5 IDH1 ATRX
17 periosteal chondrosarcoma 10.5 IDH2 IDH1
18 laryngeal neuroendocrine tumor 10.4 TP53 IDH1
19 frontal lobe neoplasm 10.4 TP53 IDH1
20 juxtacortical chondroma 10.4 IDH2 IDH1
21 cerebellar astrocytoma 10.4 KIAA1549 IDH1
22 interval angle-closure glaucoma 10.4 IDH2 IDH1
23 childhood pilocytic astrocytoma 10.4 LUC7L2 KIAA1549 IDH1
24 spinal cord glioma 10.4 LUC7L2 KIAA1549 IDH1
25 juvenile astrocytoma 10.4 LUC7L2 KIAA1549 IDH1
26 dysembryoplastic neuroepithelial tumor 10.4 LUC7L2 KIAA1549 IDH1
27 adult oligodendroglioma 10.3 KIAA1549 IDH2 IDH1
28 prostate squamous cell carcinoma 10.3 TP53 CDKN2A
29 vulvar intraepithelial neoplasia 10.3 TP53 CDKN2A
30 endometrial squamous cell carcinoma 10.3 TP53 CDKN2A
31 anaplastic oligodendroglioma 10.3 IDH2 CDKN2A
32 cerebellum cancer 10.3 TP53 KIAA1549 IDH1
33 spinal cord oligodendroglioma 10.3 TP53 IDH1 ATRX
34 multiple enchondromatosis, maffucci type 10.3 IDH2 IDH1 ATRX
35 malignant ependymoma 10.3 TP53 KIAA1549 IDH1
36 vulvar seborrheic keratosis 10.3 PTEN CDKN2A
37 ovarian seromucinous carcinoma 10.3 TP53 CDKN2A
38 breast hemangioma 10.3 TP53 IDH2 IDH1
39 cerebrum cancer 10.3 TP53 IDH1 ATRX
40 cerebral ventricle cancer 10.3 TP53 IDH1 ATRX
41 spitz nevus 10.3 TP53 CDKN2A
42 enchondromatosis, multiple, ollier type 10.3 IDH2 IDH1 ATRX
43 chondroblastic osteosarcoma 10.3 TP53 IDH2 IDH1
44 cecal benign neoplasm 10.3 PTEN CDKN2A
45 cecum adenoma 10.3 PTEN CDKN2A
46 thoracic benign neoplasm 10.3 TP53 IDH2 IDH1
47 breast duct papilloma 10.3 PTEN IDH2 IDH1
48 breast benign neoplasm 10.3 TP53 IDH2 IDH1
49 intraductal breast benign neoplasm 10.3 IDH2 IDH1
50 bizarre leiomyoma 10.3 TP53 CDKN2A

Graphical network of the top 20 diseases related to Adult Astrocytic Tumour:



Diseases related to Adult Astrocytic Tumour

Symptoms & Phenotypes for Adult Astrocytic Tumour

MGI Mouse Phenotypes related to Adult Astrocytic Tumour:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 neoplasm MP:0002006 9.43 CDKN2A IDH2 MDM2 PDGFRA PTEN TP53
2 pigmentation MP:0001186 9.02 CDKN2A MDM2 PDGFRA PTEN TP53

Drugs & Therapeutics for Adult Astrocytic Tumour

Drugs for Adult Astrocytic Tumour (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 6)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Parathyroid hormone Approved, Investigational Phase 1 9002-64-6
2
Entinostat Investigational Phase 1 209783-80-2
3 Cola Phase 1
4 Histone Deacetylase Inhibitors Phase 1
5 Liver Extracts Phase 1
6 Vaccines Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Phase I Study of an Oral Histone Deacetylase Inhibitor, MS-275, in Refractory Solid Tumors and Lymphomas Completed NCT00020579 Phase 1 entinostat
2 Recurrent GBM Stem Cell Tumor Amplified RNA Immunotherapy Trial Completed NCT00890032 Phase 1
3 A Population Based Study of Genetic Predisposition and Gene-Environment Interactions in Cancer in East Anglia, Trent and West Midlands Unknown status NCT00757614
4 A Pharmacokinetic Participation Questionnaire Study Completed NCT00890435

Search NIH Clinical Center for Adult Astrocytic Tumour

Genetic Tests for Adult Astrocytic Tumour

Anatomical Context for Adult Astrocytic Tumour

MalaCards organs/tissues related to Adult Astrocytic Tumour:

40
Bone, Liver, Brain

Publications for Adult Astrocytic Tumour

Articles related to Adult Astrocytic Tumour:

(show all 12)
# Title Authors PMID Year
1
Total copy number variation as a prognostic factor in adult astrocytoma subtypes. 61
31177992 2019
2
Expression of nerve growth factor and brain-derived neurotrophic factor in astrocytomas. 61
29391888 2018
3
Treatment Outcomes and Prognostic Factors in Adult Astrocytoma: In North East of Iran. 61
27822343 2016
4
Genomic discoveries in adult astrocytoma. 61
25616158 2015
5
ATRX and IDH1-R132H immunohistochemistry with subsequent copy number analysis and IDH sequencing as a basis for an "integrated" diagnostic approach for adult astrocytoma, oligodendroglioma and glioblastoma. 61
25427834 2015
6
Polymorphisms in the matrix metalloproteinase-1, 3, and 9 promoters and susceptibility to adult astrocytoma in northern China. 61
17502998 2007
7
Association between the functional polymorphism in the matrix metalloproteinase-7 promoter and susceptibility to adult astrocytoma. 61
16956593 2006
8
Patterns of practice and survival in a retrospective analysis of 1722 adult astrocytoma patients treated between 1985 and 2001 in 12 Italian radiation oncology centers. 61
16682131 2006
9
Somatic induction of Pten loss in a preclinical astrocytoma model reveals major roles in disease progression and avenues for target discovery and validation. 61
15958561 2005
10
Multiple angiotensin receptor subtypes in normal and tumor astrocytes in vitro. 61
12203396 2002
11
A review of astrocytoma in childhood. 61
2518326 1989
12
A study of glial fibrillary acidic protein (GFAP) in childhood brain tumours. 61
6339423 1983

Variations for Adult Astrocytic Tumour

Expression for Adult Astrocytic Tumour

Search GEO for disease gene expression data for Adult Astrocytic Tumour.

Pathways for Adult Astrocytic Tumour

Pathways related to Adult Astrocytic Tumour according to GeneCards Suite gene sharing:

(show all 25)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.74 TP53 PTEN PDGFRA MDM2 CDKN2A
2 12.71 TP53 PTEN PDGFRA MDM2 CDKN2A
3
Show member pathways
12.47 TP53 PTEN PDGFRA MDM2
4
Show member pathways
12.47 TP53 PTEN PDGFRA MDM2 CDKN2A
5 12.29 TP53 PTEN PDGFRA MDM2 CDKN2A
6
Show member pathways
12.23 TP53 PTEN MDM2 CDKN2A
7
Show member pathways
12.1 TP53 PTEN PDGFRA MDM2
8 11.95 TP53 PTEN MDM2 CDKN2A
9 11.92 TP53 PTEN MDM2
10 11.73 TP53 PTEN MDM2 CDKN2A
11 11.65 TP53 PTEN MDM2 CDKN2A
12
Show member pathways
11.62 TP53 MDM2 CDKN2A
13 11.62 TP53 MDM2 CDKN2A
14 11.61 TP53 MDM2 CDKN2A
15 11.54 TP53 PTEN ATRX
16 11.44 TP53 MDM2 CDKN2A
17 11.43 TP53 PTEN MDM2
18 11.4 TP53 PTEN PDGFRA MDM2 CDKN2A
19 11.39 TP53 PDGFRA CDKN2A
20 11.33 TP53 PTEN MDM2
21 11.11 TP53 MDM2 CDKN2A
22 10.87 TP53 PTEN PDGFRA IDH2 IDH1
23
Show member pathways
10.78 TP53 MDM2 CDKN2A
24
Show member pathways
10.72 IDH2 IDH1
25 10.67 TP53 MDM2 CDKN2A

GO Terms for Adult Astrocytic Tumour

Cellular components related to Adult Astrocytic Tumour according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 PML body GO:0016605 8.8 TP53 PTEN ATRX

Biological processes related to Adult Astrocytic Tumour according to GeneCards Suite gene sharing:

(show all 17)
# Name GO ID Score Top Affiliating Genes
1 cellular response to hypoxia GO:0071456 9.73 TP53 PTEN MDM2
2 negative regulation of transcription, DNA-templated GO:0045892 9.73 TP53 PRAMEF9 PRAMEF8 PRAMEF25 MDM2 CDKN2A
3 negative regulation of cell differentiation GO:0045596 9.58 PRAMEF9 PRAMEF8 PRAMEF25
4 positive regulation of protein export from nucleus GO:0046827 9.57 TP53 MDM2
5 positive regulation of cardiac muscle cell apoptotic process GO:0010666 9.55 TP53 PTEN
6 DNA damage response, signal transduction by p53 class mediator GO:0030330 9.54 TP53 ATRX
7 2-oxoglutarate metabolic process GO:0006103 9.52 IDH2 IDH1
8 cardiac septum morphogenesis GO:0060411 9.51 TP53 MDM2
9 replicative senescence GO:0090399 9.49 TP53 CDKN2A
10 amyloid fibril formation GO:1990000 9.48 MDM2 CDKN2A
11 NADP metabolic process GO:0006739 9.46 IDH2 IDH1
12 cellular response to UV-C GO:0071494 9.43 TP53 MDM2
13 positive regulation of cell proliferation GO:0008284 9.43 PTEN PRAMEF9 PRAMEF8 PRAMEF25 PDGFRA MDM2
14 isocitrate metabolic process GO:0006102 9.37 IDH2 IDH1
15 cellular response to actinomycin D GO:0072717 9.32 TP53 MDM2
16 glyoxylate cycle GO:0006097 9.16 IDH2 IDH1
17 negative regulation of apoptotic process GO:0043066 9.1 TP53 PTEN PRAMEF9 PRAMEF8 PRAMEF25 MDM2

Molecular functions related to Adult Astrocytic Tumour according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 disordered domain specific binding GO:0097718 9.33 TP53 MDM2 CDKN2A
2 SUMO transferase activity GO:0019789 9.32 MDM2 CDKN2A
3 platelet-derived growth factor receptor binding GO:0005161 9.26 PTEN PDGFRA
4 isocitrate dehydrogenase (NADP+) activity GO:0004450 8.96 IDH2 IDH1
5 isocitrate dehydrogenase activity GO:0004448 8.62 IDH2 IDH1

Sources for Adult Astrocytic Tumour

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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