MCID: ADL054
MIFTS: 18

Adult Brain Stem Glioma

Categories: Cancer diseases, Neuronal diseases

Aliases & Classifications for Adult Brain Stem Glioma

MalaCards integrated aliases for Adult Brain Stem Glioma:

Name: Adult Brain Stem Glioma 12 15 73
Adult Brainstem Neuroglial Tumor 12

Classifications:



External Ids:

Disease Ontology 12 DOID:4813
NCIt 50 C9091
UMLS 73 C0278873

Summaries for Adult Brain Stem Glioma

MalaCards based summary : Adult Brain Stem Glioma, is also known as adult brainstem neuroglial tumor. An important gene associated with Adult Brain Stem Glioma is BSG (Basigin (Ok Blood Group)). The drugs Etoposide and Cisplatin have been mentioned in the context of this disorder. Affiliated tissues include brain, spinal cord and bone.

Related Diseases for Adult Brain Stem Glioma

Diseases in the Brain Stem Glioma family:

Adult Brain Stem Glioma

Symptoms & Phenotypes for Adult Brain Stem Glioma

Drugs & Therapeutics for Adult Brain Stem Glioma

Drugs for Adult Brain Stem Glioma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 283)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Etoposide Approved Phase 3,Phase 2,Phase 1,Not Applicable 33419-42-0 36462
2
Cisplatin Approved Phase 3,Phase 2,Phase 1 15663-27-1 84093 441203 2767
3
Carboplatin Approved Phase 3,Phase 2,Phase 1,Not Applicable 41575-94-4 10339178 498142 38904
4
Dacarbazine Approved, Investigational Phase 2, Phase 3,Phase 1,Early Phase 1 4342-03-4 5351166
5
Mechlorethamine Approved, Investigational Phase 3,Phase 1,Phase 2 51-75-2 4033
6
Ifosfamide Approved Phase 3,Phase 1,Phase 2 3778-73-2 3690
7
Vincristine Approved, Investigational Phase 3,Phase 2,Phase 1,Not Applicable 2068-78-2, 57-22-7 5978
8
Methotrexate Approved Phase 3,Phase 2,Phase 1 1959-05-2, 59-05-2 126941
9
Temozolomide Approved, Investigational Phase 2, Phase 3,Phase 1,Early Phase 1 85622-93-1 5394
10
Lomustine Approved, Investigational Phase 3,Phase 1 13010-47-4 3950
11
Prednisone Approved, Vet_approved Phase 3 53-03-2 5865
12
Levoleucovorin Approved, Investigational Phase 3,Phase 1 68538-85-2
13
Procarbazine Approved, Investigational Phase 3,Phase 1 671-16-9 4915
14
Dexamethasone Approved, Investigational, Vet_approved Phase 3,Phase 2,Phase 1 50-02-2 5743
15
Cyproheptadine Approved Phase 3,Phase 2 129-03-3 2913
16
Histamine Approved, Investigational Phase 3,Phase 2 75614-87-8, 51-45-6 774
17
Granisetron Approved, Investigational Phase 3 109889-09-0 3510
18
Donepezil Approved Phase 3,Phase 2,Early Phase 1 120014-06-4 3152
19
Ondansetron Approved Phase 3 99614-02-5 4595
20
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 3 437-38-7 3345
21
Thioguanine Approved Phase 3 154-42-7 2723601
22
Vorinostat Approved, Investigational Phase 2, Phase 3,Phase 1 149647-78-9 5311
23
Bevacizumab Approved, Investigational Phase 2, Phase 3,Phase 1,Early Phase 1 216974-75-3
24
Dopamine Approved Phase 3,Not Applicable 51-61-6, 62-31-7 681
25
Methylphenidate Approved, Investigational Phase 3 113-45-1 4158
26
leucovorin Approved, Nutraceutical Phase 3,Phase 2,Phase 1 58-05-9 143 6006
27
Folic Acid Approved, Nutraceutical, Vet_approved Phase 3,Phase 2,Phase 1 59-30-3 6037
28 Pancreatic Polypeptide Investigational Phase 3,Phase 1 59763-91-6
29
Isophosphamide mustard Phase 3,Phase 1,Phase 2 0
30 Alkylating Agents Phase 3,Phase 2,Phase 1,Early Phase 1
31 glucocorticoids Phase 3,Phase 1
32 Folic Acid Antagonists Phase 3,Phase 2,Phase 1
33 Topoisomerase Inhibitors Phase 3,Phase 2,Phase 1,Early Phase 1,Not Applicable
34 Hormone Antagonists Phase 3,Phase 2,Phase 1
35 Dermatologic Agents Phase 3,Phase 2,Phase 1,Early Phase 1
36 Nucleic Acid Synthesis Inhibitors Phase 3,Phase 2,Phase 1
37 Hormones Phase 3,Phase 2,Phase 1
38 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3,Phase 2,Phase 1
39 Vitamin B Complex Phase 3,Phase 2,Phase 1
40 Etoposide phosphate Phase 3,Phase 2,Phase 1,Not Applicable
41 Immunosuppressive Agents Phase 3,Phase 2,Phase 1
42 Anti-Inflammatory Agents Phase 3,Phase 2,Phase 1
43 Antirheumatic Agents Phase 3,Phase 2,Phase 1
44 Antimetabolites Phase 3,Phase 2,Phase 1
45 Antimetabolites, Antineoplastic Phase 3,Phase 2,Phase 1
46 Antimitotic Agents Phase 3,Phase 2,Phase 1,Not Applicable
47 Calcium, Dietary Phase 3,Phase 2,Phase 1
48 Antineoplastic Agents, Alkylating Phase 3,Phase 2,Phase 1,Early Phase 1
49 Antineoplastic Agents, Hormonal Phase 3,Phase 2,Phase 1,Not Applicable
50 Antineoplastic Agents, Phytogenic Phase 3,Phase 2,Phase 1,Early Phase 1,Not Applicable

Interventional clinical trials:

(show top 50) (show all 195)
# Name Status NCT ID Phase Drugs
1 Prospective Trial of Two Hypofractionated Radiotherapy Regimens Versus Conventional Radiotherapy in Diffuse Brainstem Glioma in Children Unknown status NCT01878266 Phase 3
2 Combination Chemotherapy and Radiation Therapy With or Without Methotrexate in Treating Young Patients With Newly Diagnosed Gliomas Unknown status NCT00278278 Phase 3 cisplatin;etoposide;ifosfamide;lomustine;methotrexate;prednisone;vincristine sulfate
3 Hypofractionated Radiotherapy Versus Conventional Radiotherapy in Diffuse Brainstem Glioma in Children Completed NCT01635140 Phase 3
4 Vorinostat, Temozolomide, or Bevacizumab in Combination With Radiation Therapy Followed by Bevacizumab and Temozolomide in Young Patients With Newly Diagnosed High-Grade Glioma Completed NCT01236560 Phase 2, Phase 3 Temozolomide;Vorinostat
5 Fentanyl Sublingual Spray in Treating Patients With Breakthrough Cancer Pain Completed NCT00538850 Phase 3 Fentanyl sublingual spray;Placebo
6 Donepezil in Treating Patients Who Have Undergone Radiation Therapy for Brain Tumors Completed NCT00369785 Phase 3 donepezil hydrochloride;Placebo
7 Combination Chemotherapy in Treating Children With Progressive Brain Tumors Completed NCT00002944 Phase 3 carboplatin;lomustine;procarbazine hydrochloride;thioguanine;vincristine sulfate
8 Acupressure in Controlling Nausea in Young Patients Receiving Highly Emetogenic Chemotherapy Completed NCT01346267 Phase 3
9 Effect of Antineoplaston Therapy on the QT/QTc Interval In Subjects With Diffuse, Intrinsic, Brainstem Glioma Not yet recruiting NCT02864888 Phase 3 Atengenal;Astugenal
10 Study of Antineoplaston Therapy + Radiation vs. Radiation Only in Diffuse, Intrinsic, Brainstem Glioma Not yet recruiting NCT02887040 Phase 3 Atengenal;Astugenal
11 Methylphenidate to Improve Quality of Life in Patients Undergoing Radiation Therapy for Brain Tumors Terminated NCT00031798 Phase 3 methylphenidate hydrochloride
12 Cyproheptadine in Preventing Weight Loss in Children Receiving Chemotherapy for Cancer Terminated NCT01132547 Phase 3 cyproheptadine hydrochloride
13 Radiation Therapy and Tamoxifen in Treating Children With Newly Diagnosed Brain Stem Glioma Unknown status NCT00024336 Phase 2 tamoxifen citrate
14 Temozolomide and Radiation Therapy in Treating Young Patients With Pontine Glioma Unknown status NCT00514397 Phase 2 motexafin gadolinium;temozolomide
15 Proton Beam Radiation Therapy in Treating Patients With Low Grade Gliomas Unknown status NCT01024907 Phase 1, Phase 2
16 A Study of Aminolevulinic Acid (ALA) to Enhance Visualization and Resection of Malignant Glial Tumors of the Brain Unknown status NCT01403311 Phase 2 5-Aminolevuline Acid
17 Combination Chemotherapy With or Without Radiation Therapy in Treating Children With Brain Tumors Unknown status NCT00281905 Phase 2 carboplatin;cisplatin;cyclophosphamide;methotrexate;vincristine sulfate
18 Antineoplaston Therapy in Treating Patients With Brain Stem Glioma Completed NCT00003459 Phase 2 Antineoplaston therapy (Atengenal + Astugenal)
19 Thalomid and Carboplatin for the Treatment of Pediatric Brain Stem Glioma Completed NCT00179881 Phase 2 Carboplatin;Thalomid
20 A Study of Capecitabine (Xeloda®) and Concomitant Radiation Therapy in Children With Newly Diagnosed Brainstem Gliomas Completed NCT01118377 Phase 2 Capecitabine
21 Tipifarnib and Radiation Therapy in Treating Young Patients With Brainstem Glioma Completed NCT00079339 Phase 1, Phase 2 tipifarnib
22 Tipifarnib in Treating Young Patients With Recurrent or Progressive High-Grade Glioma, Medulloblastoma, Primitive Neuroectodermal Tumor, or Brain Stem Glioma Completed NCT00070525 Phase 2 tipifarnib
23 Nimotuzumab and Radiotherapy in Pediatric Patients With Glioma Completed NCT01145170 Phase 2
24 ANGIOCOMB Antiangiogenic Therapy for Pediatric Patients With Diffuse Brain Stem and Thalamic Tumors Completed NCT01756989 Phase 2 Thalidomide, etoposide, celecoxib
25 Bevacizumab and Irinotecan in Treating Young Patients With Recurrent, Progressive, or Refractory Glioma, Medulloblastoma, Ependymoma, or Low Grade Glioma Completed NCT00381797 Phase 2 Irinotecan Hydrochloride
26 Motexafin Gadolinium and Radiation Therapy in Treating Young Patients With Pontine Glioma Completed NCT00387790 Phase 2 motexafin gadolinium
27 Gefitinib and Radiation Therapy in Treating Children With Newly Diagnosed Gliomas Completed NCT00042991 Phase 1, Phase 2 gefitinib
28 O6-Benzylguanine and Temozolomide in Treating Young Patients With Recurrent or Progressive Gliomas or Brain Stem Tumors Completed NCT00275002 Phase 2 O6-benzylguanine;temozolomide
29 Rebeccamycin Analogue in Treating Children With Solid Tumors or Non-Hodgkin's Lymphoma Completed NCT00006102 Phase 2 becatecarin
30 Chemotherapy and Radiation Therapy After Surgery in Treating Children With Newly Diagnosed Astrocytoma, Glioblastoma Multiforme, Gliosarcoma, or Diffuse Intrinsic Pontine Glioma Completed NCT00028795 Phase 2 temozolomide
31 Irinotecan in Treating Patients With Recurrent Glioma Completed NCT00003134 Phase 2 irinotecan hydrochloride
32 Irinotecan in Treating Patients With Progressive or Recurrent Malignant Glioma Completed NCT00003616 Phase 1, Phase 2 irinotecan hydrochloride
33 Chemotherapy Followed by Bone Marrow or Peripheral Stem Cell Transplantation in Treating Patients With Glioblastoma Multiforme or Brain Stem Tumors Completed NCT00002619 Phase 2 carboplatin;thiotepa
34 Veliparib, Radiation Therapy, and Temozolomide in Treating Younger Patients With Newly Diagnosed Diffuse Pontine Gliomas Completed NCT01514201 Phase 1, Phase 2 Temozolomide;Veliparib
35 Bevacizumab in Reducing CNS Side Effects in Patients Who Have Undergone Radiation Therapy to the Brain for Primary Brain Tumor, Meningioma, or Head and Neck Cancer Completed NCT00492089 Phase 2 bevacizumab;placebo
36 Carboplatin in Patients With Progressive Gliomas Completed NCT00002749 Phase 2 carboplatin
37 Temozolomide in Treating Patients With Progressive Low-Grade Glioma Completed NCT00003466 Phase 2 temozolomide
38 Chemotherapy and Vaccine Therapy Followed by Bone Marrow or Peripheral Stem Cell Transplantation and Interleukin-2 in Treating Patients With Recurrent or Refractory Brain Cancer Completed NCT00014573 Phase 2 carmustine;cisplatin;cyclophosphamide;paclitaxel
39 Carmustine in Treating Adults With Recurrent Supratentorial Low-Grade Glioma Completed NCT00003467 Phase 2 carmustine;polifeprosan 20 with carmustine implant
40 Combination Chemotherapy and Tamoxifen in Treating Patients With Solid Tumors Completed NCT00002608 Phase 2 cisplatin;doxorubicin hydrochloride;tamoxifen citrate
41 Irinotecan Followed by Radiation Therapy and Temozolomide in Treating Children With Newly Diagnosed Brain Tumor Completed NCT00004068 Phase 2 irinotecan hydrochloride;temozolomide
42 Irinotecan in Combination With Cisplatin in Pediatric Patients With Unfavorable Prognosis Gliomas Completed NCT01574092 Phase 2 Combination of two marketed drugs (irinotecan and cisplatin)
43 Radiolabeled Monoclonal Antibody Therapy in Treating Patients With Primary Brain Tumors Completed NCT00003478 Phase 1, Phase 2
44 Armodafinil in Treating Fatigue Caused By Radiation Therapy in Patients With Primary Brain Tumors Completed NCT01032200 Phase 2 Armodafinil
45 Veliparib and Temozolomide in Treating Patients With Recurrent Glioblastoma Completed NCT01026493 Phase 1, Phase 2 temozolomide 60 mg x 21 days;temozolomide 75 mg x 21 days;ABT-888 20 mg x 21 days;ABT-888 40 mg x 21 days;Temozolomide 150 mg x 5 days;ABT-888 40 mg x 5 days
46 Phase II Study of Carmustine, Streptozocin, and Mercaptopurine for Refractory or Recurrent Brain Neoplasms Completed NCT00004688 Phase 2 carmustine;mercaptopurine;streptozocin
47 Phase II Studies Of Donepezil And Ginkgo Biloba In Irradiated Brain Tumor Completed NCT00070161 Phase 2 donepezil hydrochloride
48 Levetiracetam or Pregabalin in Treating Seizures in Patients Undergoing Chemotherapy and/or Radiation Therapy For Primary Brain Tumors Completed NCT00629889 Phase 2 levetiracetam;pregabalin
49 Tamoxifen, Carboplatin, and Topotecan in Treating Patients With CNS Metastases or Recurrent Brain or Spinal Cord Tumors Completed NCT00541138 Phase 2 carboplatin;tamoxifen citrate;topotecan hydrochloride
50 Temozolomide in Treating Patients With Recurrent Glioblastoma Multiforme or Other Malignant Glioma Completed NCT00498927 Phase 2 temozolomide

Search NIH Clinical Center for Adult Brain Stem Glioma

Genetic Tests for Adult Brain Stem Glioma

Anatomical Context for Adult Brain Stem Glioma

MalaCards organs/tissues related to Adult Brain Stem Glioma:

41
Brain, Spinal Cord, Bone, Liver, Bone Marrow, T Cells, Endothelial

Publications for Adult Brain Stem Glioma

Variations for Adult Brain Stem Glioma

Expression for Adult Brain Stem Glioma

Search GEO for disease gene expression data for Adult Brain Stem Glioma.

Pathways for Adult Brain Stem Glioma

GO Terms for Adult Brain Stem Glioma

Sources for Adult Brain Stem Glioma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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