MCID: ADL054
MIFTS: 36

Adult Brain Stem Glioma

Categories: Cancer diseases, Neuronal diseases

Aliases & Classifications for Adult Brain Stem Glioma

MalaCards integrated aliases for Adult Brain Stem Glioma:

Name: Adult Brain Stem Glioma 12 15 74
Adult Brainstem Neuroglial Tumor 12

Classifications:



External Ids:

Disease Ontology 12 DOID:4813
NCIt 51 C9091
UMLS 74 C0278873

Summaries for Adult Brain Stem Glioma

Disease Ontology : 12 A brain stem cancer that is characterized by mass lesion of the brainstem in adulthood, associated cranial nerve nuclei and long tracts, has material basis in abnormally proliferating cells and derives from glial cells.

MalaCards based summary : Adult Brain Stem Glioma, also known as adult brainstem neuroglial tumor, is related to achalasia and neurofibromatosis, type iv, of riccardi. An important gene associated with Adult Brain Stem Glioma is BSG (Basigin (Ok Blood Group)), and among its related pathways/superpathways are Endometrial cancer and Cell surface interactions at the vascular wall. The drugs Fentanyl and Donepezil have been mentioned in the context of this disorder. Affiliated tissues include brain, bone and liver, and related phenotypes are Decreased viability and Decreased viability

Related Diseases for Adult Brain Stem Glioma

Diseases in the Brain Stem Glioma family:

Adult Brain Stem Glioma

Diseases related to Adult Brain Stem Glioma via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 achalasia 9.9 KIT RET
2 neurofibromatosis, type iv, of riccardi 9.9 KIT RET
3 differentiated thyroid carcinoma 9.9 BSG RET
4 constipation 9.8 KIT RET
5 cerebral primitive neuroectodermal tumor 9.8 BSG SRC
6 waardenburg's syndrome 9.8 KIT RET
7 colonic disease 9.7 RET SRC
8 adenoid cystic carcinoma 9.7 BSG KIT
9 leukemia, chronic myeloid 9.7 KIT SRC
10 myelofibrosis 9.6 KIT SRC

Graphical network of the top 20 diseases related to Adult Brain Stem Glioma:



Diseases related to Adult Brain Stem Glioma

Symptoms & Phenotypes for Adult Brain Stem Glioma

GenomeRNAi Phenotypes related to Adult Brain Stem Glioma according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00221-A-1 9.9 KIT RET
2 Decreased viability GR00221-A-2 9.9 RET
3 Decreased viability GR00221-A-4 9.9 RET
4 Decreased viability GR00231-A 9.9 RET
5 Decreased viability GR00301-A 9.9 KIT RET SRC
6 Decreased viability GR00402-S-2 9.9 KIT RET SRC
7 Decreased viability in HMC1.1 cells GR00105-A-0 8.96 KIT SRC
8 Increased cell viability after pRB stimulation GR00230-A-1 8.62 KIT RET

MGI Mouse Phenotypes related to Adult Brain Stem Glioma:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 9.71 BSG KIT RET SRC
2 hematopoietic system MP:0005397 9.67 BSG KIT RET SRC
3 immune system MP:0005387 9.62 BSG KIT RET SRC
4 limbs/digits/tail MP:0005371 9.43 KIT RET SRC
5 neoplasm MP:0002006 9.33 KIT RET SRC
6 reproductive system MP:0005389 9.26 BSG KIT RET SRC
7 respiratory system MP:0005388 8.92 BSG KIT RET SRC

Drugs & Therapeutics for Adult Brain Stem Glioma

Drugs for Adult Brain Stem Glioma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 173)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 3 437-38-7 3345
2
Donepezil Approved Phase 3,Phase 2 120014-06-4 3152
3
Dopamine Approved Phase 3,Early Phase 1,Not Applicable 62-31-7, 51-61-6 681
4
Methylphenidate Approved, Investigational Phase 3 113-45-1 4158
5 Pancreatic Polypeptide Investigational Phase 3,Phase 1 59763-91-6
6 Cola Phase 3,Phase 1
7 Central Nervous System Depressants Phase 3,Phase 2
8 Peripheral Nervous System Agents Phase 3,Phase 2,Phase 1
9 Analgesics, Opioid Phase 3
10 Anesthetics Phase 3
11 Anesthetics, Intravenous Phase 3
12 Narcotics Phase 3
13 Adjuvants, Anesthesia Phase 3
14 Analgesics Phase 3,Phase 2,Phase 1
15 Liver Extracts Phase 3,Phase 2,Phase 1
16 Anesthetics, General Phase 3
17 Cholinesterase Inhibitors Phase 3,Phase 2
18 Nootropic Agents Phase 3,Phase 2
19 Neurotransmitter Agents Phase 3,Phase 2,Early Phase 1,Not Applicable
20 Cholinergic Agents Phase 3,Phase 2
21 Central Nervous System Stimulants Phase 3,Phase 2
22 Dopamine Agents Phase 3,Early Phase 1,Not Applicable
23 Dexmethylphenidate Hydrochloride Phase 3
24 Neurotransmitter Uptake Inhibitors Phase 3
25 Dopamine Uptake Inhibitors Phase 3
26
Irinotecan Approved, Investigational Phase 2,Phase 1 100286-90-6, 97682-44-5 60838
27
Bevacizumab Approved, Investigational Phase 2 216974-75-3
28
Carboplatin Approved Phase 2,Phase 1 41575-94-4 38904 10339178 498142
29
Lenograstim Approved, Investigational Phase 2,Phase 1 135968-09-1
30
Thiotepa Approved, Investigational Phase 2 52-24-4 5453
31
Carmustine Approved, Investigational Phase 2,Phase 1 154-93-8 2578
32
Iodine Approved, Investigational Phase 1, Phase 2,Phase 2 7553-56-2 807
33
Mercaptopurine Approved Phase 2 50-44-2 667490
34
Streptozocin Approved, Investigational Phase 2 18883-66-4 29327
35
Modafinil Approved, Investigational Phase 2 68693-11-8 4236
36
Temozolomide Approved, Investigational Phase 1, Phase 2,Phase 2 85622-93-1 5394
37
Pregabalin Approved, Illicit, Investigational Phase 2 148553-50-8 5486971
38
Levetiracetam Approved, Investigational Phase 2 102767-28-2 441341
39
Sodium Citrate Approved, Investigational Phase 2 68-04-2
40
Topotecan Approved, Investigational Phase 2 123948-87-8, 119413-54-6 60700
41
Tamoxifen Approved Phase 2 10540-29-1 2733526
42
Paclitaxel Approved, Vet_approved Phase 2,Phase 1 33069-62-4 36314
43
Cyclophosphamide Approved, Investigational Phase 2 6055-19-2, 50-18-0 2907
44
Cisplatin Approved Phase 2,Phase 1 15663-27-1 441203 84093 2767
45
Aldesleukin Approved Phase 2,Phase 1 85898-30-2, 110942-02-4
46
Sargramostim Approved, Investigational Phase 2,Phase 1 123774-72-1, 83869-56-1
47
Doxorubicin Approved, Investigational Phase 2 23214-92-8 31703
48
Dexamethasone Approved, Investigational, Vet_approved Phase 2 50-02-2 5743
49
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 2 1177-87-3
50
Promethazine Approved, Investigational Phase 2 60-87-7 4927

Interventional clinical trials:

(show top 50) (show all 69)
# Name Status NCT ID Phase Drugs
1 Fentanyl Sublingual Spray in Treating Patients With Breakthrough Cancer Pain Completed NCT00538850 Phase 3 Fentanyl sublingual spray;Placebo
2 Donepezil in Treating Patients Who Have Undergone Radiation Therapy for Brain Tumors Completed NCT00369785 Phase 3 donepezil hydrochloride;Placebo
3 Methylphenidate to Improve Quality of Life in Patients Undergoing Radiation Therapy for Brain Tumors Terminated NCT00031798 Phase 3 methylphenidate hydrochloride
4 Proton Beam Radiation Therapy in Treating Patients With Low Grade Gliomas Unknown status NCT01024907 Phase 1, Phase 2
5 Antineoplaston Therapy in Treating Patients With Brain Stem Glioma Completed NCT00003459 Phase 2 Antineoplaston therapy (Atengenal + Astugenal)
6 Irinotecan in Treating Patients With Recurrent Glioma Completed NCT00003134 Phase 2 irinotecan hydrochloride
7 Irinotecan in Treating Patients With Progressive or Recurrent Malignant Glioma Completed NCT00003616 Phase 1, Phase 2 irinotecan hydrochloride
8 Bevacizumab in Reducing CNS Side Effects in Patients Who Have Undergone Radiation Therapy to the Brain for Primary Brain Tumor, Meningioma, or Head and Neck Cancer Completed NCT00492089 Phase 2 bevacizumab;placebo
9 Chemotherapy Followed by Bone Marrow or Peripheral Stem Cell Transplantation in Treating Patients With Glioblastoma Multiforme or Brain Stem Tumors Completed NCT00002619 Phase 2 carboplatin;thiotepa
10 Carmustine in Treating Adults With Recurrent Supratentorial Low-Grade Glioma Completed NCT00003467 Phase 2 carmustine;polifeprosan 20 with carmustine implant
11 Radiolabeled Monoclonal Antibody Therapy in Treating Patients With Primary Brain Tumors Completed NCT00003478 Phase 1, Phase 2
12 Carboplatin in Patients With Progressive Gliomas Completed NCT00002749 Phase 2 carboplatin
13 Phase II Study of Carmustine, Streptozocin, and Mercaptopurine for Refractory or Recurrent Brain Neoplasms Completed NCT00004688 Phase 2 carmustine;mercaptopurine;streptozocin
14 Armodafinil in Treating Fatigue Caused By Radiation Therapy in Patients With Primary Brain Tumors Completed NCT01032200 Phase 2 Armodafinil
15 Veliparib and Temozolomide in Treating Patients With Recurrent Glioblastoma Completed NCT01026493 Phase 1, Phase 2 temozolomide 60 mg x 21 days;temozolomide 75 mg x 21 days;ABT-888 20 mg x 21 days;ABT-888 40 mg x 21 days;Temozolomide 150 mg x 5 days;ABT-888 40 mg x 5 days
16 Phase II Studies Of Donepezil And Ginkgo Biloba In Irradiated Brain Tumor Completed NCT00070161 Phase 2 donepezil hydrochloride
17 Levetiracetam or Pregabalin in Treating Seizures in Patients Undergoing Chemotherapy and/or Radiation Therapy For Primary Brain Tumors Completed NCT00629889 Phase 2 levetiracetam;pregabalin
18 Tamoxifen, Carboplatin, and Topotecan in Treating Patients With CNS Metastases or Recurrent Brain or Spinal Cord Tumors Completed NCT00541138 Phase 2 carboplatin;tamoxifen citrate;topotecan hydrochloride
19 Temozolomide in Treating Patients With Recurrent Glioblastoma Multiforme or Other Malignant Glioma Completed NCT00498927 Phase 2 temozolomide
20 Chemotherapy and Vaccine Therapy Followed by Bone Marrow or Peripheral Stem Cell Transplantation and Interleukin-2 in Treating Patients With Recurrent or Refractory Brain Cancer Completed NCT00014573 Phase 2 carmustine;cisplatin;cyclophosphamide;paclitaxel
21 Talampanel in Treating Patients With Recurrent High-Grade Glioma Completed NCT00064363 Phase 2 talampanel
22 Temozolomide in Treating Patients With Progressive Low-Grade Glioma Completed NCT00003466 Phase 2 temozolomide
23 Combination Chemotherapy and Tamoxifen in Treating Patients With Solid Tumors Completed NCT00002608 Phase 2 cisplatin;doxorubicin hydrochloride;tamoxifen citrate
24 Iodine I 131 Monoclonal Antibody 3F8 in Treating Patients With Central Nervous System Cancer or Leptomeningeal Cancer Active, not recruiting NCT00445965 Phase 2
25 Ritonavir and Lopinavir in Treating Patients With Progressive or Recurrent High-Grade Glioma Terminated NCT01095094 Phase 2 ritonavir;lopinavir
26 Carboplatin, Temozolomide, and Filgrastim in Treating Patients With Newly Diagnosed or Recurrent High-Grade Glioma Withdrawn NCT00006263 Phase 2 carboplatin;temozolomide
27 Photodynamic Therapy With Porfimer Sodium in Treating Patients With Refractory Brain Tumors Unknown status NCT00002647 Phase 1 verteporfin
28 Stereotactic Radiosurgery in Treating Patients With Brain Tumors Completed NCT00019578 Phase 1
29 Gamma-Secretase Inhibitor RO4929097 and Cediranib Maleate in Treating Patients With Advanced Solid Tumors Completed NCT01131234 Phase 1 Gamma-Secretase Inhibitor RO4929097;Cediranib Maleate
30 RO4929097, Temozolomide, and Radiation Therapy in Treating Patients With Newly Diagnosed Malignant Glioma Completed NCT01119599 Phase 1 Gamma-Secretase Inhibitor RO4929097;Temozolomide
31 Erlotinib in Treating Patients With Solid Tumors and Liver or Kidney Dysfunction Completed NCT00030498 Phase 1 erlotinib hydrochloride
32 Internal Radiation Therapy Plus Carmustine Implants in Treating Patients With Recurrent or Refractory Malignant Glioma Completed NCT00003876 Phase 1 polifeprosan 20 with carmustine implant
33 O6-Benzylguanine and Carmustine Implants in Treating Patients With Recurrent Malignant Glioma Completed NCT00004892 Phase 1 O6-benzylguanine;polifeprosan 20 with carmustine implant
34 Combination Chemotherapy Plus Gene Therapy in Treating Patients With CNS Tumors Completed NCT00005796 Phase 1 lomustine;procarbazine hydrochloride;vincristine sulfate
35 Carmustine Wafers Plus Irinotecan in Treating Patients With Recurrent Supratentorial High Grade Gliomas Completed NCT00003463 Phase 1 carmustine;irinotecan hydrochloride;polifeprosan 20 with carmustine implant
36 Calcitriol Plus Carboplatin in Treating Patients With Advanced Solid Tumors Completed NCT00008086 Phase 1 carboplatin
37 Phase I Study of Cellular Immunotherapy for Recurrent/Refractory Malignant Glioma Using Intratumoral Infusions of GRm13Z40-2, An Allogeneic CD8+ Cytolitic T-Cell Line Genetically Modified to Express the IL 13-Zetakine and HyTK and to be Resistant to Glucocorticoids, in Combination With Interleukin-2 Completed NCT01082926 Phase 1
38 A Feasibility, Dose-Escalation Study Using Intracerebral Microdialysis to Assess the Neuropharmacodynamics of Temsirolimus in Patients With Primary or Metastatic Brain Tumors Completed NCT00784914 Phase 1 temsirolimus
39 Cellular Adoptive Immunotherapy Using Genetically Modified T-Lymphocytes in Treating Patients With Recurrent or Refractory High-Grade Malignant Glioma Completed NCT00730613 Phase 1
40 Bortezomib and Temozolomide in Treating Patients With Brain Tumors or Other Solid Tumors That Have Not Responded to Treatment Completed NCT00544284 Phase 1 bortezomib;temozolomide
41 Sodium Stibogluconate and IFNa-2b Followed By CDDP, VLB and DTIC Treating Pts.With Advanced Melanoma or Other Cancers Completed NCT00498979 Phase 1 cisplatin;sodium stibogluconate;dacarbazine;vinblastine
42 Tumor Tissue Analysis in Patients Receiving Imatinib Mesylate for Malignant Glioma Completed NCT00401024 Phase 1 imatinib mesylate
43 Imatinib Mesylate, Vatalanib, and Hydroxyurea in Treating Patients With Recurrent or Relapsed Malignant Glioma Completed NCT00387933 Phase 1 hydroxyurea;imatinib mesylate;vatalanib
44 CC-8490 in Treating Patients With Recurrent or Refractory High-Grade Gliomas Completed NCT00074243 Phase 1 CC-8490
45 Thalidomide and Docetaxel in Treating Patients With Advanced Cancer Completed NCT00049296 Phase 1 docetaxel;thalidomide
46 Yttrium Y 90 SMT 487 in Treating Patients With Refractory or Recurrent Cancer Completed NCT00006368 Phase 1
47 CC-5013 in Treating Patients With Recurrent Glioma Completed NCT00036894 Phase 1 lenalidomide
48 MS-275 in Treating Patients With Advanced Solid Tumors or Lymphoma Completed NCT00020579 Phase 1 entinostat
49 Carboxyamidotriazole and Paclitaxel in Treating Patients With Advanced Solid Tumors or Refractory Lymphomas Completed NCT00019019 Phase 1 carboxyamidotriazole;paclitaxel
50 Monoclonal Antibody Therapy in Treating Patients With Leptomeningeal Cancer Completed NCT00003022 Phase 1

Search NIH Clinical Center for Adult Brain Stem Glioma

Genetic Tests for Adult Brain Stem Glioma

Anatomical Context for Adult Brain Stem Glioma

MalaCards organs/tissues related to Adult Brain Stem Glioma:

42
Brain, Bone, Liver, Bone Marrow, Kidney, Spinal Cord, T Cells

Publications for Adult Brain Stem Glioma

Variations for Adult Brain Stem Glioma

Expression for Adult Brain Stem Glioma

Search GEO for disease gene expression data for Adult Brain Stem Glioma.

Pathways for Adult Brain Stem Glioma

GO Terms for Adult Brain Stem Glioma

Biological processes related to Adult Brain Stem Glioma according to GeneCards Suite gene sharing:

(show all 19)
# Name GO ID Score Top Affiliating Genes
1 phosphorylation GO:0016310 9.69 KIT RET SRC
2 protein phosphorylation GO:0006468 9.67 KIT RET SRC
3 leukocyte migration GO:0050900 9.58 BSG SRC
4 protein autophosphorylation GO:0046777 9.58 KIT SRC
5 positive regulation of gene expression GO:0010628 9.58 KIT RET SRC
6 homophilic cell adhesion via plasma membrane adhesion molecules GO:0007156 9.57 BSG RET
7 cell differentiation GO:0030154 9.56 RET SRC
8 positive regulation of MAPK cascade GO:0043410 9.55 KIT RET
9 activation of MAPK activity GO:0000187 9.54 KIT RET
10 phosphatidylinositol phosphorylation GO:0046854 9.52 KIT SRC
11 positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 9.48 KIT SRC
12 positive regulation of MAP kinase activity GO:0043406 9.43 KIT SRC
13 axon guidance GO:0007411 9.43 BSG RET SRC
14 positive regulation of phosphatidylinositol 3-kinase activity GO:0043552 9.37 KIT SRC
15 peptidyl-tyrosine phosphorylation GO:0018108 9.33 KIT RET SRC
16 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.32 KIT SRC
17 negative regulation of apoptotic process GO:0043066 9.16 SRC
18 positive regulation of protein kinase B signaling GO:0051897 9.13 KIT RET SRC
19 transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 8.8 KIT RET SRC

Molecular functions related to Adult Brain Stem Glioma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 kinase activity GO:0016301 9.5 KIT RET SRC
2 Ras guanyl-nucleotide exchange factor activity GO:0005088 9.37 KIT RET
3 protein kinase activity GO:0004672 9.33 KIT RET SRC
4 phosphatidylinositol-4,5-bisphosphate 3-kinase activity GO:0046934 9.26 KIT SRC
5 transmembrane receptor protein tyrosine kinase activity GO:0004714 8.96 KIT RET
6 protein tyrosine kinase activity GO:0004713 8.8 KIT RET SRC

Sources for Adult Brain Stem Glioma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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