MCID: ADL054
MIFTS: 18

Adult Brain Stem Glioma

Categories: Cancer diseases, Neuronal diseases

Aliases & Classifications for Adult Brain Stem Glioma

MalaCards integrated aliases for Adult Brain Stem Glioma:

Name: Adult Brain Stem Glioma 12 15 73
Adult Brainstem Neuroglial Tumor 12

Classifications:



External Ids:

Disease Ontology 12 DOID:4813
NCIt 50 C9091
UMLS 73 C0278873

Summaries for Adult Brain Stem Glioma

Disease Ontology : 12 A brain stem cancer that is characterized by mass lesion of the brainstem in adulthood, associated cranial nerve nuclei and long tracts, has material basis in abnormally proliferating cells and derives from glial cells.

MalaCards based summary : Adult Brain Stem Glioma, is also known as adult brainstem neuroglial tumor. An important gene associated with Adult Brain Stem Glioma is BSG (Basigin (Ok Blood Group)). The drugs Fentanyl and Donepezil have been mentioned in the context of this disorder. Affiliated tissues include brain, t cells and liver.

Related Diseases for Adult Brain Stem Glioma

Diseases in the Brain Stem Glioma family:

Adult Brain Stem Glioma

Symptoms & Phenotypes for Adult Brain Stem Glioma

Drugs & Therapeutics for Adult Brain Stem Glioma

Drugs for Adult Brain Stem Glioma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 170)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 3 437-38-7 3345
2
Donepezil Approved Phase 3,Phase 2 120014-06-4 3152
3
Dopamine Approved Phase 3,Early Phase 1,Not Applicable 51-61-6, 62-31-7 681
4
Methylphenidate Approved, Investigational Phase 3 113-45-1 4158
5 Pancreatic Polypeptide Investigational Phase 3,Phase 1 59763-91-6
6 Cola Phase 3,Phase 1
7 Central Nervous System Depressants Phase 3,Phase 2
8 Adjuvants, Anesthesia Phase 3
9 Liver Extracts Phase 3,Phase 2,Phase 1
10 Anesthetics, Intravenous Phase 3
11 Analgesics, Opioid Phase 3
12 Peripheral Nervous System Agents Phase 3,Phase 2,Phase 1
13 Anesthetics, General Phase 3
14 Analgesics Phase 3,Phase 2,Phase 1
15 Narcotics Phase 3
16 Anesthetics Phase 3
17 Neurotransmitter Agents Phase 3,Phase 2,Early Phase 1,Not Applicable
18 Nootropic Agents Phase 3,Phase 2
19 Cholinergic Agents Phase 3,Phase 2
20 Cholinesterase Inhibitors Phase 3,Phase 2
21 Central Nervous System Stimulants Phase 3,Phase 2
22 Dopamine Agents Phase 3,Early Phase 1,Not Applicable
23 Dexmethylphenidate Hydrochloride Phase 3
24 Neurotransmitter Uptake Inhibitors Phase 3
25 Dopamine Uptake Inhibitors Phase 3
26
Irinotecan Approved, Investigational Phase 2,Phase 1 100286-90-6, 97682-44-5 60838
27
Bevacizumab Approved, Investigational Phase 2 216974-75-3
28
Carboplatin Approved Phase 2,Phase 1 41575-94-4 10339178 38904 498142
29
Lenograstim Approved, Investigational Phase 2,Phase 1 135968-09-1
30
Thiotepa Approved, Investigational Phase 2 52-24-4 5453
31
Carmustine Approved, Investigational Phase 2,Phase 1 154-93-8 2578
32
Iodine Approved, Investigational Phase 1, Phase 2,Phase 2 7553-56-2 807
33
Streptozocin Approved, Investigational Phase 2 18883-66-4 29327
34
Armodafinil Approved, Investigational Phase 2 112111-43-0
35
Modafinil Approved, Investigational Phase 2 68693-11-8 4236
36
Dacarbazine Approved, Investigational Phase 1, Phase 2,Phase 2 4342-03-4 5351166
37
Temozolomide Approved, Investigational Phase 1, Phase 2,Phase 2 85622-93-1 5394
38 Piracetam Approved, Investigational Phase 2 7491-74-9
39
Pregabalin Approved, Illicit, Investigational Phase 2 148553-50-8 5486971
40
Tamoxifen Approved Phase 2 10540-29-1 2733526
41
Topotecan Approved, Investigational Phase 2 123948-87-8, 119413-54-6 60700
42
Cyclophosphamide Approved, Investigational Phase 2 6055-19-2, 50-18-0 2907
43
Paclitaxel Approved, Vet_approved Phase 2,Phase 1 33069-62-4 36314
44
Aldesleukin Approved Phase 2,Phase 1 85898-30-2, 110942-02-4
45
Cisplatin Approved Phase 2,Phase 1 15663-27-1 2767 441203 84093
46
Doxorubicin Approved, Investigational Phase 2 23214-92-8 31703
47
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 2 1177-87-3
48
Promethazine Approved, Investigational Phase 2 60-87-7 4927
49
Acetaminophen Approved Phase 2 103-90-2 1983
50
Diphenhydramine Approved, Investigational Phase 2 147-24-0, 58-73-1 3100

Interventional clinical trials:

(show top 50) (show all 69)
# Name Status NCT ID Phase Drugs
1 Fentanyl Sublingual Spray in Treating Patients With Breakthrough Cancer Pain Completed NCT00538850 Phase 3 Fentanyl sublingual spray;Placebo
2 Donepezil in Treating Patients Who Have Undergone Radiation Therapy for Brain Tumors Completed NCT00369785 Phase 3 donepezil hydrochloride;Placebo
3 Methylphenidate to Improve Quality of Life in Patients Undergoing Radiation Therapy for Brain Tumors Terminated NCT00031798 Phase 3 methylphenidate hydrochloride
4 Proton Beam Radiation Therapy in Treating Patients With Low Grade Gliomas Unknown status NCT01024907 Phase 1, Phase 2
5 Antineoplaston Therapy in Treating Patients With Brain Stem Glioma Completed NCT00003459 Phase 2 Antineoplaston therapy (Atengenal + Astugenal)
6 Irinotecan in Treating Patients With Recurrent Glioma Completed NCT00003134 Phase 2 irinotecan hydrochloride
7 Irinotecan in Treating Patients With Progressive or Recurrent Malignant Glioma Completed NCT00003616 Phase 1, Phase 2 irinotecan hydrochloride
8 Bevacizumab in Reducing CNS Side Effects in Patients Who Have Undergone Radiation Therapy to the Brain for Primary Brain Tumor, Meningioma, or Head and Neck Cancer Completed NCT00492089 Phase 2 bevacizumab;placebo
9 Chemotherapy Followed by Bone Marrow or Peripheral Stem Cell Transplantation in Treating Patients With Glioblastoma Multiforme or Brain Stem Tumors Completed NCT00002619 Phase 2 carboplatin;thiotepa
10 Carmustine in Treating Adults With Recurrent Supratentorial Low-Grade Glioma Completed NCT00003467 Phase 2 carmustine;polifeprosan 20 with carmustine implant
11 Radiolabeled Monoclonal Antibody Therapy in Treating Patients With Primary Brain Tumors Completed NCT00003478 Phase 1, Phase 2
12 Carboplatin in Patients With Progressive Gliomas Completed NCT00002749 Phase 2 carboplatin
13 Phase II Study of Carmustine, Streptozocin, and Mercaptopurine for Refractory or Recurrent Brain Neoplasms Completed NCT00004688 Phase 2 carmustine;mercaptopurine;streptozocin
14 Armodafinil in Treating Fatigue Caused By Radiation Therapy in Patients With Primary Brain Tumors Completed NCT01032200 Phase 2 Armodafinil
15 Veliparib and Temozolomide in Treating Patients With Recurrent Glioblastoma Completed NCT01026493 Phase 1, Phase 2 temozolomide 60 mg x 21 days;temozolomide 75 mg x 21 days;ABT-888 20 mg x 21 days;ABT-888 40 mg x 21 days;Temozolomide 150 mg x 5 days;ABT-888 40 mg x 5 days
16 Phase II Studies Of Donepezil And Ginkgo Biloba In Irradiated Brain Tumor Completed NCT00070161 Phase 2 donepezil hydrochloride
17 Levetiracetam or Pregabalin in Treating Seizures in Patients Undergoing Chemotherapy and/or Radiation Therapy For Primary Brain Tumors Completed NCT00629889 Phase 2 levetiracetam;pregabalin
18 Tamoxifen, Carboplatin, and Topotecan in Treating Patients With CNS Metastases or Recurrent Brain or Spinal Cord Tumors Completed NCT00541138 Phase 2 carboplatin;tamoxifen citrate;topotecan hydrochloride
19 Temozolomide in Treating Patients With Recurrent Glioblastoma Multiforme or Other Malignant Glioma Completed NCT00498927 Phase 2 temozolomide
20 Chemotherapy and Vaccine Therapy Followed by Bone Marrow or Peripheral Stem Cell Transplantation and Interleukin-2 in Treating Patients With Recurrent or Refractory Brain Cancer Completed NCT00014573 Phase 2 carmustine;cisplatin;cyclophosphamide;paclitaxel
21 Talampanel in Treating Patients With Recurrent High-Grade Glioma Completed NCT00064363 Phase 2 talampanel
22 Temozolomide in Treating Patients With Progressive Low-Grade Glioma Completed NCT00003466 Phase 2 temozolomide
23 Combination Chemotherapy and Tamoxifen in Treating Patients With Solid Tumors Completed NCT00002608 Phase 2 cisplatin;doxorubicin hydrochloride;tamoxifen citrate
24 Iodine I 131 Monoclonal Antibody 3F8 in Treating Patients With Central Nervous System Cancer or Leptomeningeal Cancer Active, not recruiting NCT00445965 Phase 2
25 Ritonavir and Lopinavir in Treating Patients With Progressive or Recurrent High-Grade Glioma Terminated NCT01095094 Phase 2 ritonavir;lopinavir
26 Carboplatin, Temozolomide, and Filgrastim in Treating Patients With Newly Diagnosed or Recurrent High-Grade Glioma Withdrawn NCT00006263 Phase 2 carboplatin;temozolomide
27 Photodynamic Therapy With Porfimer Sodium in Treating Patients With Refractory Brain Tumors Unknown status NCT00002647 Phase 1 verteporfin
28 Stereotactic Radiosurgery in Treating Patients With Brain Tumors Completed NCT00019578 Phase 1
29 Gamma-Secretase Inhibitor RO4929097 and Cediranib Maleate in Treating Patients With Advanced Solid Tumors Completed NCT01131234 Phase 1 Gamma-Secretase Inhibitor RO4929097;Cediranib Maleate
30 RO4929097, Temozolomide, and Radiation Therapy in Treating Patients With Newly Diagnosed Malignant Glioma Completed NCT01119599 Phase 1 Gamma-Secretase Inhibitor RO4929097;Temozolomide
31 Erlotinib in Treating Patients With Solid Tumors and Liver or Kidney Dysfunction Completed NCT00030498 Phase 1 erlotinib hydrochloride
32 Internal Radiation Therapy Plus Carmustine Implants in Treating Patients With Recurrent or Refractory Malignant Glioma Completed NCT00003876 Phase 1 polifeprosan 20 with carmustine implant
33 O6-Benzylguanine and Carmustine Implants in Treating Patients With Recurrent Malignant Glioma Completed NCT00004892 Phase 1 O6-benzylguanine;polifeprosan 20 with carmustine implant
34 Combination Chemotherapy Plus Gene Therapy in Treating Patients With CNS Tumors Completed NCT00005796 Phase 1 lomustine;procarbazine hydrochloride;vincristine sulfate
35 Carmustine Wafers Plus Irinotecan in Treating Patients With Recurrent Supratentorial High Grade Gliomas Completed NCT00003463 Phase 1 carmustine;irinotecan hydrochloride;polifeprosan 20 with carmustine implant
36 Calcitriol Plus Carboplatin in Treating Patients With Advanced Solid Tumors Completed NCT00008086 Phase 1 carboplatin
37 Phase I Study of Cellular Immunotherapy for Recurrent/Refractory Malignant Glioma Using Intratumoral Infusions of GRm13Z40-2, An Allogeneic CD8+ Cytolitic T-Cell Line Genetically Modified to Express the IL 13-Zetakine and HyTK and to be Resistant to Glucocorticoids, in Combination With Interleukin-2 Completed NCT01082926 Phase 1
38 A Feasibility, Dose-Escalation Study Using Intracerebral Microdialysis to Assess the Neuropharmacodynamics of Temsirolimus in Patients With Primary or Metastatic Brain Tumors Completed NCT00784914 Phase 1 temsirolimus
39 Cellular Adoptive Immunotherapy Using Genetically Modified T-Lymphocytes in Treating Patients With Recurrent or Refractory High-Grade Malignant Glioma Completed NCT00730613 Phase 1
40 Bortezomib and Temozolomide in Treating Patients With Brain Tumors or Other Solid Tumors That Have Not Responded to Treatment Completed NCT00544284 Phase 1 bortezomib;temozolomide
41 Sodium Stibogluconate and IFNa-2b Followed By CDDP, VLB and DTIC Treating Pts.With Advanced Melanoma or Other Cancers Completed NCT00498979 Phase 1 cisplatin;sodium stibogluconate;dacarbazine;vinblastine
42 Tumor Tissue Analysis in Patients Receiving Imatinib Mesylate for Malignant Glioma Completed NCT00401024 Phase 1 imatinib mesylate
43 Imatinib Mesylate, Vatalanib, and Hydroxyurea in Treating Patients With Recurrent or Relapsed Malignant Glioma Completed NCT00387933 Phase 1 hydroxyurea;imatinib mesylate;vatalanib
44 CC-8490 in Treating Patients With Recurrent or Refractory High-Grade Gliomas Completed NCT00074243 Phase 1 CC-8490
45 Thalidomide and Docetaxel in Treating Patients With Advanced Cancer Completed NCT00049296 Phase 1 docetaxel;thalidomide
46 Yttrium Y 90 SMT 487 in Treating Patients With Refractory or Recurrent Cancer Completed NCT00006368 Phase 1
47 CC-5013 in Treating Patients With Recurrent Glioma Completed NCT00036894 Phase 1 lenalidomide
48 MS-275 in Treating Patients With Advanced Solid Tumors or Lymphoma Completed NCT00020579 Phase 1 entinostat
49 Carboxyamidotriazole and Paclitaxel in Treating Patients With Advanced Solid Tumors or Refractory Lymphomas Completed NCT00019019 Phase 1 carboxyamidotriazole;paclitaxel
50 Monoclonal Antibody Therapy in Treating Patients With Leptomeningeal Cancer Completed NCT00003022 Phase 1

Search NIH Clinical Center for Adult Brain Stem Glioma

Genetic Tests for Adult Brain Stem Glioma

Anatomical Context for Adult Brain Stem Glioma

MalaCards organs/tissues related to Adult Brain Stem Glioma:

41
Brain, T Cells, Liver, Bone, Spinal Cord

Publications for Adult Brain Stem Glioma

Variations for Adult Brain Stem Glioma

Expression for Adult Brain Stem Glioma

Search GEO for disease gene expression data for Adult Brain Stem Glioma.

Pathways for Adult Brain Stem Glioma

GO Terms for Adult Brain Stem Glioma

Sources for Adult Brain Stem Glioma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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