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MCID: ADL054
MIFTS: 34

Adult Brain Stem Glioma

Categories: Cancer diseases, Neuronal diseases
Genes Tissues Related diseases Pathways Drugs
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Aliases & Classifications for Adult Brain Stem Glioma

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MalaCards integrated aliases for Adult Brain Stem Glioma:

Name: Adult Brain Stem Glioma 12 15 72
Adult Brainstem Neuroglial Tumor 12

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Neuronal diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:4813
NCIt 50 C9091
UMLS 72 C0278873
Sources

Summaries for Adult Brain Stem Glioma

About this section
Disease Ontology : 12 A brain stem cancer that is characterized by mass lesion of the brainstem in adulthood, associated cranial nerve nuclei and long tracts, has material basis in abnormally proliferating cells and derives from glial cells.

MalaCards based summary : Adult Brain Stem Glioma, also known as adult brainstem neuroglial tumor, is related to fibrillary astrocytoma and pleomorphic xanthoastrocytoma. An important gene associated with Adult Brain Stem Glioma is BSG (Basigin (Ok Blood Group)), and among its related pathways/superpathways are Endometrial cancer and Cell surface interactions at the vascular wall. The drugs Donepezil and Fentanyl have been mentioned in the context of this disorder. Affiliated tissues include brain, t cells and liver, and related phenotypes are Decreased viability and Decreased viability

Sources

Related Diseases for Adult Brain Stem Glioma

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Diseases in the Brain Stem Glioma family:

Adult Brain Stem Glioma

Diseases related to Adult Brain Stem Glioma via text searches within MalaCards or GeneCards Suite gene sharing:

(showing 30, show less)
# Related Disease Score Top Affiliating Genes
1 fibrillary astrocytoma 10.3 MGMT IDH1
2 pleomorphic xanthoastrocytoma 10.3 MGMT IDH1
3 brain glioma 10.2 MGMT IDH1
4 giant cell glioblastoma 10.2 MGMT IDH1
5 cerebral primitive neuroectodermal tumor 10.2 SRC BSG
6 lymphoepithelioma-like thymic carcinoma 10.1 KIT IDH1
7 adenosquamous lung carcinoma 10.1 RET PIK3CA
8 spinal cord astrocytoma 10.1 MGMT IDH1 BSG
9 aggressive digital papillary adenocarcinoma 10.1 PIK3CA KIT
10 brain stem glioma 10.1 PIK3CA IDH1 BSG
11 lung adenoid cystic carcinoma 10.1 PIK3CA KIT
12 cerebrum cancer 10.1 MGMT IDH1
13 mast-cell leukemia 10.0 PIK3CA KIT
14 papillary hidradenoma 10.0 PIK3CA KIT
15 supratentorial cancer 10.0 MGMT IDH1
16 glioblastoma multiforme 9.9 PIK3CA MGMT IDH1
17 adamantinoma of long bones 9.9 RET PIK3CA MGMT
18 adenosquamous carcinoma 9.8 PIK3CA KIT
19 achalasia 9.8 RET KIT
20 brain cancer 9.8 PIK3CA MGMT IDH1
21 undifferentiated pleomorphic sarcoma 9.8 PIK3CA KIT IDH1
22 bladder urothelial carcinoma 9.8 PIK3CA KIT IDH1
23 melanoma, cutaneous malignant 1 9.8 PIK3CA MGMT KIT
24 adenocarcinoma 9.7 RET PIK3CA KIT
25 myelofibrosis 9.6 SRC KIT IDH1
26 lung cancer susceptibility 3 9.5 SRC PIK3CA IDH1
27 large intestine cancer 9.5 SRC PIK3CA MGMT IDH1
28 glioblastoma 9.5 SRC PIK3CA MGMT IDH1
29 adenoid cystic carcinoma 9.5 PIK3CA KIT IDH1 BSG
30 gastric adenocarcinoma 9.1 PIK3CA MGMT KIT

Graphical network of the top 20 diseases related to Adult Brain Stem Glioma:



Diseases related to Adult Brain Stem Glioma
Sources

Symptoms & Phenotypes for Adult Brain Stem Glioma

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GenomeRNAi Phenotypes related to Adult Brain Stem Glioma according to GeneCards Suite gene sharing:

26 (showing 7, show less)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00221-A-1 9.7 KIT RET
2 Decreased viability GR00221-A-2 9.7 RET
3 Decreased viability GR00221-A-4 9.7 RET
4 Decreased viability GR00231-A 9.7 RET
5 Decreased viability GR00301-A 9.7 KIT RET SRC
6 Decreased viability GR00402-S-2 9.7 KIT RET SRC
7 Decreased viability in HMC1.1 cells GR00105-A-0 8.62 KIT SRC

MGI Mouse Phenotypes related to Adult Brain Stem Glioma:

46 (showing 3, show less)
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 9.63 BSG KIT MGMT PIK3CA RET SRC
2 neoplasm MP:0002006 9.35 KIT MGMT PIK3CA RET SRC
3 respiratory system MP:0005388 9.1 BSG IDH1 KIT MGMT RET SRC
Sources

Drugs & Therapeutics for Adult Brain Stem Glioma

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Drugs for Adult Brain Stem Glioma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(showing 156, show less)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Donepezil Approved Phase 3 120014-06-4 3152
2
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 3 437-38-7 3345
3
Dopamine Approved Phase 3 51-61-6, 62-31-7 681
4
Methylphenidate Approved, Investigational Phase 3 113-45-1 4158
5 Pancreatic Polypeptide Investigational Phase 3 59763-91-6
6 Analgesics Phase 3
7 Central Nervous System Depressants Phase 3
8 Nootropic Agents Phase 3
9 Peripheral Nervous System Agents Phase 3
10 Cholinesterase Inhibitors Phase 3
11 Cholinergic Agents Phase 3
12 Liver Extracts Phase 3
13 Cola Phase 3
14 Anesthetics, Intravenous Phase 3
15 Narcotics Phase 3
16 Analgesics, Opioid Phase 3
17 Adjuvants, Anesthesia Phase 3
18 Anesthetics, General Phase 3
19 Anesthetics Phase 3
20 Central Nervous System Stimulants Phase 3
21 Neurotransmitter Agents Phase 3
22 Dexmethylphenidate Hydrochloride Phase 3
23 Neurotransmitter Uptake Inhibitors Phase 3
24 Dopamine Uptake Inhibitors Phase 3
25 Dopamine Agents Phase 3
26
Mercaptopurine Approved Phase 2 50-44-2 667490
27
Streptozocin Approved, Investigational Phase 2 18883-66-4 29327
28
Pregabalin Approved, Illicit, Investigational Phase 2 148553-50-8 5486971
29
Levetiracetam Approved, Investigational Phase 2 102767-28-2 441341
30
Irinotecan Approved, Investigational Phase 2 100286-90-6, 97682-44-5 60838
31
Modafinil Approved, Investigational Phase 2 68693-11-8 4236
32
Aldesleukin Approved Phase 2 85898-30-2, 110942-02-4
33
Thiotepa Approved, Investigational Phase 2 52-24-4 5453
34
Cisplatin Approved Phase 2 15663-27-1 84093 441203 2767
35
Tamoxifen Approved Phase 2 10540-29-1 2733526
36
Sodium citrate Approved, Investigational Phase 2 68-04-2
37
Doxorubicin Approved, Investigational Phase 2 23214-92-8 31703
38
Topotecan Approved, Investigational Phase 2 123948-87-8, 119413-54-6 60700
39
Paclitaxel Approved, Vet_approved Phase 2 33069-62-4 36314
40
Cyclophosphamide Approved, Investigational Phase 2 50-18-0, 6055-19-2 2907
41
Iodine Approved, Investigational Phase 2 7553-56-2 807
42
Acetaminophen Approved Phase 2 103-90-2 1983
43
Promethazine Approved, Investigational Phase 2 60-87-7 4927
44
Dexamethasone Approved, Investigational, Vet_approved Phase 2 50-02-2 5743
45
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 2 1177-87-3
46
Diphenhydramine Approved, Investigational Phase 2 58-73-1, 147-24-0 3100
47
Lopinavir Approved Phase 2 192725-17-0 92727
48
Ritonavir Approved, Investigational Phase 2 155213-67-5 392622
49
Calcium Approved, Nutraceutical Phase 2 7440-70-2 271
50
Citric acid Approved, Nutraceutical, Vet_approved Phase 2 77-92-9 311
51
Veliparib Investigational Phase 1, Phase 2 912444-00-9 11960529
52 Immunosuppressive Agents Phase 2
53 Anti-Bacterial Agents Phase 2
54 Antibiotics, Antitubercular Phase 2
55 Nucleic Acid Synthesis Inhibitors Phase 2
56 Antimetabolites Phase 2
57 Antimetabolites, Antineoplastic Phase 2
58 Tranquilizing Agents Phase 2
59 Hormones Phase 2
60 Anti-Anxiety Agents Phase 2
61 Psychotropic Drugs Phase 2
62 Anticonvulsants Phase 2
63 calcium channel blockers Phase 2
64 Calcium, Dietary Phase 2
65 topoisomerase I inhibitors Phase 2
66 Topoisomerase Inhibitors Phase 2
67 Cytochrome P-450 CYP3A Inducers Phase 2
68 Cytochrome P-450 Enzyme Inducers Phase 2
69 Wakefulness-Promoting Agents Phase 2
70 Hormone Antagonists Phase 2
71 Interleukin-2 Phase 2
72 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 2
73 Ginkgo Phase 2
74 Estrogens Phase 2
75 Citrate Phase 2
76 Selective Estrogen Receptor Modulators Phase 2
77
Liposomal doxorubicin Phase 2 31703
78 Estrogen Receptor Modulators Phase 2
79 Estrogen Receptor Antagonists Phase 2
80 Antineoplastic Agents, Hormonal Phase 2
81 Estrogen Antagonists Phase 2
82 Bone Density Conservation Agents Phase 2
83 Albumin-Bound Paclitaxel Phase 2
84 Vaccines Phase 2
85 Antirheumatic Agents Phase 2
86 Poly(ADP-ribose) Polymerase Inhibitors Phase 1, Phase 2
87 cadexomer iodine Phase 2
88 Antibodies Phase 2
89 Antineoplastic Agents, Immunological Phase 2
90 Antibodies, Monoclonal Phase 2
91 Immunoglobulins Phase 2
92 Micronutrients Phase 2
93 Trace Elements Phase 2
94 Nutrients Phase 2
95 Anti-Infective Agents, Local Phase 2
96 BB 1101 Phase 2
97 HIV Protease Inhibitors Phase 2
98 Cytochrome P-450 CYP3A Inhibitors Phase 2
99
protease inhibitors Phase 2
100 Cytochrome P-450 Enzyme Inhibitors Phase 2
101 Anti-Infective Agents Phase 2
102 Anti-HIV Agents Phase 2
103 Anti-Retroviral Agents Phase 2
104 Antiviral Agents Phase 2
105
Trioxsalen Approved Phase 1 3902-71-4 5585
106
Verteporfin Approved, Investigational Phase 1 129497-78-5
107
Lenalidomide Approved Phase 1 191732-72-6 216326
108
Hydroxyurea Approved Phase 1 127-07-1 3657
109
Sirolimus Approved, Investigational Phase 1 53123-88-9 6436030 5284616 46835353
110
Everolimus Approved Phase 1 159351-69-6 6442177 70789204
111
Miconazole Approved, Investigational, Vet_approved Phase 1 22916-47-8 4189
112
Procarbazine Approved, Investigational Phase 1 671-16-9 4915
113
Lomustine Approved, Investigational Phase 1 13010-47-4 3950
114
Vincristine Approved, Investigational Phase 1 57-22-7, 2068-78-2 5978
115
Bortezomib Approved, Investigational Phase 1 179324-69-7 93860 387447
116
Vinblastine Approved Phase 1 865-21-4 241903 13342
117
Dacarbazine Approved, Investigational Phase 1 4342-03-4 5351166
118
Somatostatin Approved, Investigational Phase 1 38916-34-6, 51110-01-1 53481605
119
Octreotide Approved, Investigational Phase 1 83150-76-9 383414 6400441
120
Docetaxel Approved, Investigational Phase 1 114977-28-5 148124
121
Carmustine Approved, Investigational Phase 1 154-93-8 2578
122
Mechlorethamine Approved, Investigational Phase 1 51-75-2 4033
123
Melphalan Approved Phase 1 148-82-3 460612 4053
124
Sargramostim Approved, Investigational Phase 1 83869-56-1, 123774-72-1
125
Calcitriol Approved, Nutraceutical Phase 1 32222-06-3 5280453 134070
126
Vatalanib Investigational Phase 1 212141-54-3 151194
127 Dihematoporphyrin Ether Phase 1
128 Dermatologic Agents Phase 1
129 Photosensitizing Agents Phase 1
130 Imatinib Mesylate Phase 1 220127-57-1 123596
131 Protein Kinase Inhibitors Phase 1
132 Angiogenesis Inhibitors Phase 1
133 Angiogenesis Modulating Agents Phase 1
134 Analgesics, Non-Narcotic Phase 1
135 glucocorticoids Phase 1
136 Dialysis Solutions Phase 1
137 Antifungal Agents Phase 1
138 Mitogens Phase 1
139 Vitamins Phase 1
140 Vasoconstrictor Agents Phase 1
141 Antineoplastic Agents, Phytogenic Phase 1
142 Tubulin Modulators Phase 1
143 Antimitotic Agents Phase 1
144 Interferon alpha-2 Phase 1
145 Interferon-alpha Phase 1
146 Anthelmintics Phase 1
147 interferons Phase 1
148 Antiparasitic Agents Phase 1
149 Antiprotozoal Agents Phase 1
150 Antimony Sodium Gluconate Phase 1
151 Carboxyamido-triazole Phase 1
152 Gastrointestinal Agents Phase 1
153 Radiopharmaceuticals Phase 1
154 Edotreotide Phase 1
155 phenylalanine Phase 1
156 O(6)-benzylguanine Phase 1

Interventional clinical trials:

(showing 55, show less)
# Name Status NCT ID Phase Drugs
1 Phase III Double Blind, Placebo Controlled Study of Donepezil in the Irradiated Brain Completed NCT00369785 Phase 3 donepezil hydrochloride;Placebo
2 A Randomized, Double-blind, Placebo-controlled Multi-center Study to Evaluate the Safety and Efficacy of Fentanyl Sublingual Spray (Fentanyl SL Spray) for the Treatment of Breakthrough Cancer Pain Completed NCT00538850 Phase 3 Fentanyl sublingual spray;Placebo
3 A Phase III, Double-Blind, Prospective Randomized Clinical Trial of the Effect of D-threo-methylphenidate HCl (d-MPH) on Quality of Life in Brain Tumor Patients Receiving Radiation Therapy Terminated NCT00031798 Phase 3 methylphenidate hydrochloride
4 Phase II Study of Carmustine, Streptozocin, and Mercaptopurine for Refractory or Recurrent Brain Neoplasms Completed NCT00004688 Phase 2 carmustine;mercaptopurine;streptozocin
5 Phase II Study of Antineoplastons A10 and AS2-1 In Patients With Brain Stem Glioma Completed NCT00003459 Phase 2 Antineoplaston therapy (Atengenal + Astugenal)
6 Phase II Treatment of Adults With Recurrent Supratentorial Low Grade Glioma With Gliadel Wafers Completed NCT00003467 Phase 2 carmustine;polifeprosan 20 with carmustine implant
7 Phase II Treatment of Adults and Children With Progressive Low Grade Gliomas With Temodal Completed NCT00003466 Phase 2 temozolomide
8 PHASE II STUDY OF CARBOPLATIN (CBDCA) IN THE TREATMENT OF CHILDREN AND ADULTS WITH PROGRESSIVE LOW GRADE GLIOMAS Completed NCT00002749 Phase 2 carboplatin
9 A Phase II Trial of Continuous Low-Dose Temozolomide for Patients With Recurrent Malignant Glioma Completed NCT00498927 Phase 2 temozolomide
10 Levetiracetam and Pregabalin for Monotherapy in Patients With Brain Tumors and Seizures. A Phase II Randomized Study. Completed NCT00629889 Phase 2 levetiracetam;pregabalin
11 A Phase II Trial Of Talampanel In Patients With Recurrent High-Grade Gliomas Completed NCT00064363 Phase 2 talampanel
12 A Phase II Trial of Irinotecan in Recurrent Glioma Completed NCT00003134 Phase 2 irinotecan hydrochloride
13 A Feasibility Study of Armodafinil for Brain Radiation-Induced Fatigue Completed NCT01032200 Phase 2 Armodafinil
14 Phase I/II Trial of Irinotecan (CPT-11) in Patients With Recurrent Malignant Glioma Completed NCT00003616 Phase 1, Phase 2 irinotecan hydrochloride
15 Phase I Study of Intra-Tumoral, Radiolabeled, Anti-Tenascin Monoclonal Antibody 81C6 in the Treatment of Patients With Malignant Primary Brain Tumors Completed NCT00003478 Phase 1, Phase 2
16 Donepezil and EGb761 in Improving Neurocognitive Function in Patients Who Have Previously Undergone Radiation Therapy for Primary Brain Tumor or Brain Metastases Completed NCT00070161 Phase 2 donepezil hydrochloride
17 A TRIAL OF INTENSIVE CHEMOTHERAPY AND AUTOLOGOUS STEM CELL RECONSTITUTION FOR PATIENTS BETWEEN SIX AND SIXTY YEARS OF AGE, WITH NON-PROGRESSIVE GLIOBLASTOMA MULTIFORME OR DIFFUSE INTRINSIC BRAINSTEM TUMORS, FOLLOWING INITIAL LOCAL-FIELD IRRADIATION Completed NCT00002619 Phase 2 carboplatin;thiotepa
18 Cisplatin, Doxorubicin and Tamoxifen in the Treatment of Incurable Soft Tissue and Endocrine Malignancies Completed NCT00002608 Phase 2 cisplatin;doxorubicin hydrochloride;tamoxifen citrate
19 A Pilot Study of Tamoxifen, Carboplatin and Topotecan in the Treatment of Recurrent or Refractory Primary Brain or Spinal Cord Tumors or Metastatic Epithelial Cancers With Central Nervous System Metastases Completed NCT00541138 Phase 2 carboplatin;tamoxifen citrate;topotecan hydrochloride
20 Phase II Trial Of High Dose Cyclophosphamide, Cisplatin And Carmustine With Stem Cell Reconstitution Followed By Specific Cellular Therapy In Patients With Recurrent Or Refractory Brain Tumors Completed NCT00014573 Phase 2 carmustine;cisplatin;cyclophosphamide;paclitaxel
21 A Randomized Phase I/II Study of ABT-888 in Combination With Temozolomide in Recurrent (Temozolomide Resistant) Glioblastoma Completed NCT01026493 Phase 1, Phase 2 temozolomide 60 mg x 21 days;temozolomide 75 mg x 21 days;ABT-888 20 mg x 21 days;ABT-888 40 mg x 21 days;Temozolomide 150 mg x 5 days;ABT-888 40 mg x 5 days
22 Phase II Study of Intrathecal I-3F8 in Patients With GD2-Expressing Central Nervous System and Leptomeningeal Neoplasms Active, not recruiting NCT00445965 Phase 2
23 Phase II Trial of Ritonavir/Lopinavir in Patients With Progressive of Recurrent High-Grade Gliomas Terminated NCT01095094 Phase 2 ritonavir;lopinavir
24 Phase II Trial of Temozolomide, Carboplatin and Neupogen in High-Grade Gliomas, Both Newly-Diagnosed and Recurrent Withdrawn NCT00006263 Phase 2 carboplatin;temozolomide
25 Photodynamic Therapy For Childhood Brain Tumors, A Phase I Study Unknown status NCT00002647 Phase 1 verteporfin
26 Determination of the In-Tumor-Concentration of Imatinib Mesylate in Malignant Glioma After Oral Administration Completed NCT00401024 Phase 1 imatinib mesylate
27 A Phase I Trial Of A Thalidomide Analog, CC-5013, For The Treatment Of Patients With Recurrent High-Grade Gliomas Completed NCT00036894 Phase 1 lenalidomide
28 Phase I Pilot Study of Stereotaxic Radiosurgery in Patients With Intracranial Neoplasms Completed NCT00019578 Phase 1
29 A Phase I Trial Of CC-8490 For The Treatment Of Patients With Recurrent/Refractory High-Grade Gliomas Completed NCT00074243 Phase 1 CC-8490
30 Phase I Treatment of Adults With Recurrent Supratentorial High Grade Glioma With Gliadel Wafers Plus Irinotecan (CPT-11) Completed NCT00003463 Phase 1 carmustine;irinotecan hydrochloride;polifeprosan 20 with carmustine implant
31 Phase I Study of Cellular Immunotherapy for Recurrent/Refractory Malignant Glioma Using Intratumoral Infusions of GRm13Z40-2, An Allogeneic CD8+ Cytolitic T-Cell Line Genetically Modified to Express the IL 13-Zetakine and HyTK and to be Resistant to Glucocorticoids, in Combination With Interleukin-2 Completed NCT01082926 Phase 1
32 Phase I GLIADEL and Continuous Infusion of Intravenous O6-Benzylguanine Trial in Patients With Recurrent Malignant Glioma Completed NCT00004892 Phase 1 O6-benzylguanine;polifeprosan 20 with carmustine implant
33 A Phase I Study of Concurrent Multi-modality Treatment for Patients With Relapsed Malignant Glioma Using Permanent I-125 Interstitial Seeds and Dose Escalation of Gliadel 3.85% Carmustine (BCNU) Polymer Wafers Completed NCT00003876 Phase 1 polifeprosan 20 with carmustine implant
34 Phase I Study of Intrathecal 131-I-3F8 Monoclonal Antibody in Patients With GD2 Positive Leptomeningeal Neoplasms Completed NCT00003022 Phase 1
35 Phase I Dose Escalation of Gleevec in Combination With PTK787/ZK 222584 (PTK/ZK) Plus Hydroxyurea Completed NCT00387933 Phase 1 hydroxyurea;imatinib mesylate;vatalanib
36 Pilot Feasibility and Safety Study of Cellular Immunotherapy for Recurrent/Refractory Malignant Glioma Using Genetically-Modified Autologous CD8+ T Cell Clones Completed NCT00730613 Phase 1
37 A Pilot Feasibility, Dose-Escalation Study Using Intracerebral Microdialysis to Assess the Neuropharmacodynamics of Temsirolimus in Patients With Primary or Metastatic Brain Tumors Completed NCT00784914 Phase 1 temsirolimus
38 A Phase I Trial of Subcutaneous And/Or Oral Calcitriol [(1,25-COH)2D3] and Carboplatin in Advanced Solid Tumors Completed NCT00008086 Phase 1 carboplatin
39 A Pilot Study of Dose-Intensified Procarbazine, CCNU, Vincristine (PCV) for Poor Prognosis Pediatric and Adult Brain Tumors Utilizing Fibronectin-Assisted, Retroviral-Mediated Modification of CD34+ Peripheral Blood Cells With O6-Methylguanine DNA Methyltransferase Completed NCT00005796 Phase 1 lomustine;procarbazine hydrochloride;vincristine sulfate
40 A Phase I Study of Bortezomib and Temozolomide in Patients With Refractory Solid Tumors Completed NCT00544284 Phase 1 bortezomib;temozolomide
41 Phase I Evaluation of Sodium Stibogluconate in Combination With Interferon α-2b Followed by Cisplatin, Vinblastine and Dacarbazine for Patients With Melanoma or Malignancies Potentially Responsive to SSG and/or Interferons Completed NCT00498979 Phase 1 cisplatin;sodium stibogluconate;dacarbazine;vinblastine
42 A PHASE I STUDY OF THE COMBINATION OF CAI AND PACLITAXEL IN ADULT PATIENTS WITH REFRACTORY CANCERS OR LYMPHOMA Completed NCT00019019 Phase 1 carboxyamidotriazole;paclitaxel
43 A Phase I, Open-Label, Maximum Tolerated Single-Cycle and Four-Cycle Dose-Finding Study to Evaluation the Safety and Tolerability of 90Y-SMT 487 Administered by Intravenous Infusion to Subjects With Refractory Somatostatin-Receptor Positive Tumors Completed NCT00006368 Phase 1
44 Phase I Pharmacokinetic Trial of Thalidomide and Docetaxel: A Regimen Based on Anti-Angiogenic Therapeutic Principles Completed NCT00049296 Phase 1 docetaxel;thalidomide
45 Intra-Arterial Melphalan (L-Phenylalanine Mustard) Administered in Conjunction With Osmotic Blood-Brain Barrier Disruption in Patients With Brain Malignancies: A Phase I Study Terminated NCT00253721 Phase 1 Melphalan
46 Mutant MGMT Gene Transfer Into Human Hematopoietic Progenitors to Protect Hematopoiesis During O6-Benzylguanine (BG, NSC 637037) and Carmustine Followed by Temozolomide Therapy of Advanced Solid Tumors Terminated NCT00003567 Phase 1 O6-benzylguanine;carmustine;temozolomide
47 A Population Based Study of Genetic Predisposition and Gene-Environment Interactions in Cancer in East Anglia, Trent and West Midlands Unknown status NCT00757614
48 Identification of Genes Involved in the Pathogenesis of Gliomas by Transcriptome Analysis Completed NCT00967200
49 Prospective Study on the Short-Term Adverse Effects From Gamma Knife Radiosurgery Completed NCT00255671
50 Temozolomide Induced Changes in Semen/Sperm Analysis in Men With Newly Diagnosed, Progressive or Recurrent Primary Malignant Brain Tumors Completed NCT00499798
51 San Francisco Bay Area Adult Glioma Prognosis Study Protocol Completed NCT01009307
52 Comprehensive Molecular Analysis of Tumor Samples Derived From Patients With Diffuse Brainstem Glioma - A Pilot Study Completed NCT00899834
53 A Pharmacokinetic Participation Questionnaire Study Completed NCT00890435
54 A Pharmacokinetic and Pharmacogenomic Study of Patients With High-Grade Gliomas Receiving Daily Radiation Therapy and Temozolomide Terminated NCT00471653 temozolomide
55 Perfusion Magnetic Resonance Imaging of Brain Tumors: Correlation With Indicators of Angiogenesis Withdrawn NCT00005790

Search NIH Clinical Center for Adult Brain Stem Glioma

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Genetic Tests for Adult Brain Stem Glioma

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Anatomical Context for Adult Brain Stem Glioma

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MalaCards organs/tissues related to Adult Brain Stem Glioma:

41
Brain, T Cells, Liver, Bone, Spinal Cord
Sources

Publications for Adult Brain Stem Glioma

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Variations for Adult Brain Stem Glioma

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Expression for Adult Brain Stem Glioma

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Search GEO for disease gene expression data for Adult Brain Stem Glioma.
Sources

Pathways for Adult Brain Stem Glioma

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Pathways related to Adult Brain Stem Glioma according to GeneCards Suite gene sharing:

(showing 34, show less)
# Super pathways Score Top Affiliating Genes
1
Endometrial cancer 37
Show member pathways
 12.58 SRC RET PIK3CA KIT
2
Cell surface interactions at the vascular wall 66
Show member pathways
 11.97 SRC PIK3CA BSG
3
GDNF-Family Ligands and Receptor Interactions 64
Show member pathways
 11.92 SRC RET PIK3CA
4
Kit receptor signaling pathway 1
Show member pathways
 11.89 SRC PIK3CA KIT
5
Tyrosine Kinases / Adaptors 4
11.78 SRC RET KIT
6
VEGF Pathway (Tocris) 61
Show member pathways
 11.42 RET PIK3CA KIT
7
Signaling events mediated by focal adhesion kinase 1
11.39 SRC PIK3CA
8
PDGFR-beta signaling pathway 1
11.39 SRC PIK3CA
9
Signaling events mediated by PTP1B 1
11.35 SRC PIK3CA
10
Aryl Hydrocarbon Receptor 1
11.33 SRC RET
11
Thymic Stromal LymphoPoietin (TSLP) Signaling Pathway 1
11.32 SRC PIK3CA
12
FGF signaling pathway 1
11.31 SRC PIK3CA
13
Integrins in angiogenesis 1
11.3 SRC PIK3CA
14
Paxillin-dependent events mediated by a4b1 1
Show member pathways
 11.28 SRC PIK3CA
15
Signaling events mediated by TCPTP 1
Show member pathways
 11.25 SRC PIK3CA
16
Class I PI3K signaling events 1
11.24 SRC PIK3CA
17
Internalization of ErbB1 1
11.15 SRC PIK3CA
18
CXCR3-mediated signaling events 1
11.14 SRC PIK3CA
19
E-cadherin signaling in the nascent adherens junction 1
11.12 SRC PIK3CA
20
Trk receptor signaling mediated by PI3K and PLC-gamma 1
11.1 SRC PIK3CA
21
Ephrin B reverse signaling 1
11.02 SRC PIK3CA
22
Plasma membrane estrogen receptor signaling 1
11 SRC PIK3CA
23
Nectin adhesion pathway 1
10.97 SRC PIK3CA
24
EGF receptor (ErbB1) signaling pathway 1
10.97 SRC PIK3CA
25
Angiogenesis (WikiPathways) 1
10.94 SRC PIK3CA
26
G-protein signaling_H-RAS regulation pathway 22
10.9 SRC RET PIK3CA
27
E-cadherin signaling in keratinocytes 1
10.77 SRC PIK3CA
28
Central carbon metabolism in cancer 37
10.76 RET PIK3CA KIT IDH1
29
Nongenotropic Androgen signaling 1
10.73 SRC PIK3CA
30
Signaling events regulated by Ret tyrosine kinase 1
10.71 SRC RET PIK3CA
31
EPHA2 forward signaling 1
10.69 SRC PIK3CA
32
Regulation of KIT signaling 66
10.61 SRC KIT
33
Atypical NF-kappaB pathway 1
10.51 SRC PIK3CA
34
RNAi Pathway 64
9.91 SRC RET PIK3CA
Sources

GO Terms for Adult Brain Stem Glioma

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Biological processes related to Adult Brain Stem Glioma according to GeneCards Suite gene sharing:

(showing 15, show less)
# Name GO ID Score Top Affiliating Genes
1 phosphorylation GO:0016310 9.8 SRC RET PIK3CA KIT
2 protein phosphorylation GO:0006468 9.76 SRC RET PIK3CA KIT
3 response to drug GO:0042493 9.71 SRC RET MGMT
4 leukocyte migration GO:0050900 9.61 SRC PIK3CA BSG
5 T cell costimulation GO:0031295 9.55 SRC PIK3CA
6 peptidyl-tyrosine phosphorylation GO:0018108 9.54 SRC RET KIT
7 epidermal growth factor receptor signaling pathway GO:0007173 9.52 SRC PIK3CA
8 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.51 SRC KIT
9 positive regulation of phosphatidylinositol 3-kinase activity GO:0043552 9.48 SRC KIT
10 negative regulation of apoptotic process GO:0043066 9.4 SRC MGMT
11 transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 9.33 SRC RET KIT
12 negative regulation of anoikis GO:2000811 9.32 SRC PIK3CA
13 axon guidance GO:0007411 9.26 SRC RET PIK3CA BSG
14 phosphatidylinositol phosphorylation GO:0046854 8.96 PIK3CA
15 positive regulation of protein kinase B signaling GO:0051897 8.92 SRC RET PIK3CA KIT

Molecular functions related to Adult Brain Stem Glioma according to GeneCards Suite gene sharing:

(showing 6, show less)
# Name GO ID Score Top Affiliating Genes
1 transferase activity GO:0016740 9.77 SRC RET PIK3CA MGMT KIT
2 kinase activity GO:0016301 9.46 SRC RET PIK3CA KIT
3 cadherin binding GO:0045296 9.43 SRC IDH1 BSG
4 transmembrane receptor protein tyrosine kinase activity GO:0004714 9.32 RET KIT
5 protein tyrosine kinase activity GO:0004713 9.13 SRC RET KIT
6 phosphatidylinositol-4,5-bisphosphate 3-kinase activity GO:0046934 8.32 PIK3CA
Sources

Sources for Adult Brain Stem Glioma

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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