MCID: ADL022
MIFTS: 16

Adult Central Nervous System Primitive Neuroectodermal Neoplasm

Categories: Cancer diseases, Neuronal diseases

Aliases & Classifications for Adult Central Nervous System Primitive Neuroectodermal Neoplasm

MalaCards integrated aliases for Adult Central Nervous System Primitive Neuroectodermal Neoplasm:

Name: Adult Central Nervous System Primitive Neuroectodermal Neoplasm 12 15
Adult Central Nervous System Primitive Neuroectodermal Tumor 71
Adult Cns Pnet 12

Classifications:



External Ids:

Disease Ontology 12 DOID:3865
NCIt 49 C5411
UMLS 71 C1332196

Summaries for Adult Central Nervous System Primitive Neuroectodermal Neoplasm

MalaCards based summary : Adult Central Nervous System Primitive Neuroectodermal Neoplasm, also known as adult central nervous system primitive neuroectodermal tumor, is related to supratentorial primitive neuroectodermal tumor and supratentorial cancer. An important gene associated with Adult Central Nervous System Primitive Neuroectodermal Neoplasm is IDH1 (Isocitrate Dehydrogenase (NADP(+)) 1), and among its related pathways/superpathways is Neural Stem Cell Differentiation Pathways and Lineage-specific Markers. Related phenotypes are hearing/vestibular/ear and nervous system

Related Diseases for Adult Central Nervous System Primitive Neuroectodermal Neoplasm

Diseases in the Central Nervous System Primitive Neuroectodermal Neoplasm family:

Adult Central Nervous System Primitive Neuroectodermal Neoplasm

Diseases related to Adult Central Nervous System Primitive Neuroectodermal Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 11)
# Related Disease Score Top Affiliating Genes
1 supratentorial primitive neuroectodermal tumor 9.9 SHH IDH1
2 supratentorial cancer 9.9 SHH IDH1
3 brain stem glioma 9.8 SHH IDH1
4 li-fraumeni syndrome 9.7 SHH IDH1
5 cerebellar medulloblastoma 9.6 SHH ATOH1
6 adult medulloblastoma 9.6 SHH ATOH1
7 central nervous system cancer 9.6 SHH IDH1
8 basal cell nevus syndrome 9.5 SHH ATOH1
9 cerebellum cancer 9.4 SHH IDH1 ATOH1
10 infratentorial cancer 9.3 SHH IDH1 ATOH1
11 medulloblastoma 8.9 SHH IDH1 HIC1 ATOH1

Graphical network of the top 20 diseases related to Adult Central Nervous System Primitive Neuroectodermal Neoplasm:



Diseases related to Adult Central Nervous System Primitive Neuroectodermal Neoplasm

Symptoms & Phenotypes for Adult Central Nervous System Primitive Neuroectodermal Neoplasm

MGI Mouse Phenotypes related to Adult Central Nervous System Primitive Neuroectodermal Neoplasm:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 hearing/vestibular/ear MP:0005377 9.46 ATOH1 CDKN2D HIC1 SHH
2 nervous system MP:0003631 9.35 ATOH1 CDKN2D FABP7 HIC1 SHH
3 respiratory system MP:0005388 8.92 ATOH1 CDKN2D IDH1 SHH

Drugs & Therapeutics for Adult Central Nervous System Primitive Neuroectodermal Neoplasm

Search Clinical Trials , NIH Clinical Center for Adult Central Nervous System Primitive Neuroectodermal Neoplasm

Genetic Tests for Adult Central Nervous System Primitive Neuroectodermal Neoplasm

Anatomical Context for Adult Central Nervous System Primitive Neuroectodermal Neoplasm

Publications for Adult Central Nervous System Primitive Neuroectodermal Neoplasm

Variations for Adult Central Nervous System Primitive Neuroectodermal Neoplasm

Expression for Adult Central Nervous System Primitive Neuroectodermal Neoplasm

Search GEO for disease gene expression data for Adult Central Nervous System Primitive Neuroectodermal Neoplasm.

Pathways for Adult Central Nervous System Primitive Neuroectodermal Neoplasm

Pathways related to Adult Central Nervous System Primitive Neuroectodermal Neoplasm according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.52 SHH FABP7

GO Terms for Adult Central Nervous System Primitive Neuroectodermal Neoplasm

Biological processes related to Adult Central Nervous System Primitive Neuroectodermal Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 central nervous system development GO:0007417 9.16 SHH ATOH1
2 negative regulation of Wnt signaling pathway GO:0030178 8.96 SHH HIC1
3 inner ear development GO:0048839 8.62 SHH ATOH1

Sources for Adult Central Nervous System Primitive Neuroectodermal Neoplasm

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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