Adult Cystic Nephroma disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Adult Cystic Nephroma

MalaCards integrated aliases for Adult Cystic Nephroma:

Name: Adult Cystic Nephroma ¹² ¹⁵

Multilocular Cystic Nephroma, Mixed Epithelial Stromal Tumour and Renal Epithelial Stromal Tumour ¹²

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Nephrological diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:2673

NCIt ⁴⁹ C7504

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Summaries for Adult Cystic Nephroma

Disease Ontology : ¹² A nephroma that is characterized as a localized, well-circumscribed multilocular tumor lined by hobnail epithelium.

MalaCards based summary : Adult Cystic Nephroma, also known as multilocular cystic nephroma, mixed epithelial stromal tumour and renal epithelial stromal tumour, is related to nephroma and cervical adenomyoma. An important gene associated with Adult Cystic Nephroma is PGR (Progesterone Receptor), and among its related pathways/superpathways are Mesenchymal Stem Cells and Lineage-specific Markers and Dendritic Cells Developmental Lineage Pathway. Affiliated tissues include kidney, and related phenotypes are cardiovascular system and cellular

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Related Diseases for Adult Cystic Nephroma

Diseases in the Adult Cystic Nephroma family:

Malignant Cystic Nephroma

Diseases related to Adult Cystic Nephroma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 153)

#	Related Disease	Score	Top Affiliating Genes
1	nephroma	28.2	PGR MME MEST KIT DES ACTC1
2	cervical adenomyoma	10.2	PGR MME
3	adenomyoma	10.2	PGR MME
4	fallopian tube endometriosis	10.2	PGR MME
5	cervical benign neoplasm	10.2	PGR MME
6	uterine corpus adenosarcoma	10.2	PGR MME
7	cervical serous adenocarcinoma	10.2	PGR MME
8	breast leiomyoma	10.2	PGR MME
9	breast metaplastic carcinoma	10.2	PGR MME
10	vulvar leiomyoma	10.2	PGR MME
11	pancreatic mucinous cystadenoma	10.2	PGR MME
12	ovarian endometrioid stromal sarcoma	10.2	PGR MME
13	eccrine papillary adenocarcinoma	10.2	PGR MME
14	cutaneous adenocystic carcinoma	10.2	PGR MME
15	breast sarcoma	10.2	PGR MME
16	leiomyomatosis	10.2	PGR KIT
17	urethral benign neoplasm	10.2	PGR MME
18	cervical adenoma malignum	10.2	PGR MME
19	breast osteosarcoma	10.2	PGR MME
20	intraductal breast benign neoplasm	10.2	PGR MME
21	breast benign neoplasm	10.2	PGR MME
22	vaginal cancer	10.2	PGR MME
23	sweat gland benign neoplasm	10.2	PGR MME
24	liver leiomyoma	10.2	PGR KIT
25	mulchandani-bhoj-conlin syndrome	10.2	PGR MME
26	urethra leiomyoma	10.1	MME KIT
27	thoracic benign neoplasm	10.1	PGR MME
28	prostate stromal sarcoma	10.1	PGR KIT
29	mucocele of appendix	10.1	MME KIT
30	uterus leiomyosarcoma	10.1	PGR KIT
31	mixed epithelial stromal tumour	10.1	MME MEST
32	cribriform carcinoma	10.1	PGR KIT
33	ovarian mixed germ cell neoplasm	10.1	MME KIT
34	microglandular adenosis	10.1	PGR KIT
35	vulvar disease	10.1	PGR KIT
36	endobronchial leiomyoma	10.1	MME KIT
37	endometrial stromal tumor	10.1	PGR MME
38	tubular adenocarcinoma	10.1	PGR MME
39	uterine benign neoplasm	10.1	PGR MME
40	pleomorphic carcinoma	10.1	PGR KIT
41	reproductive organ benign neoplasm	10.1	PGR MME
42	calcifying aponeurotic fibroma	10.1	PGR ACTC1
43	glycogen-rich clear cell breast carcinoma	10.1	PGR ACTC1
44	kidney cortex disease	10.1	MME MEST
45	bizarre leiomyoma	10.1	PGR ACTC1
46	breast myoepithelial carcinoma	10.1	PGR ACTC1
47	myxoid leiomyosarcoma	10.1	PGR ACTC1
48	tonsil cancer	10.1	PGR KIT
49	adenomyosis	10.1	PGR MME
50	breast fibroadenoma	10.1	PGR MME

Graphical network of the top 20 diseases related to Adult Cystic Nephroma:

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Symptoms & Phenotypes for Adult Cystic Nephroma

MGI Mouse Phenotypes related to Adult Cystic Nephroma:

⁴⁵

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	cardiovascular system	MP:0005385	9.55	ACTC1 DES KIT MEST PGR
2	cellular	MP:0005384	9.43	ACTC1 DES KIT MEST MME PGR
3	muscle	MP:0005369	9.02	ACTC1 DES KIT MEST PGR

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Drugs & Therapeutics for Adult Cystic Nephroma

Interventional clinical trials:

#	Name	Status	NCT ID	Phase	Drugs
1	Renal Tumors Classification, Biology, and Banking Study	Suspended	NCT00898365

Search NIH Clinical Center for Adult Cystic Nephroma

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Genetic Tests for Adult Cystic Nephroma

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Anatomical Context for Adult Cystic Nephroma

MalaCards organs/tissues related to Adult Cystic Nephroma:

⁴⁰

Kidney

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Publications for Adult Cystic Nephroma

Articles related to Adult Cystic Nephroma:

(show all 12)

#	Title	Authors	PMID	Year
1	Can contrast enhanced ultrasound differentiate benign cystic nephroma from malignant multicystic renal lesions? A case report. ⁶¹	Chua N...Liyanage SH	31867215	2020
2	Tubulocystic renal cell carcinoma: a review of literature focused on radiological findings for differential diagnosis. ⁶¹	Honda Y...Awai K	29796844	2018
3	Pediatric Cystic Nephroma Is Morphologically, Immunohistochemically, and Genetically Distinct From Adult Cystic Nephroma. ⁶¹	Li Y...Argani P	28177962	2017
4	Ultrasound Imaging of Cystic Nephroma. ⁶¹	Greco F...Grasso RF	28752022	2017
5	[Laparoscopic nephron-sparing surgery for treatment of complex cystic renal lesions]. ⁶¹	Liu YQ...Ma LL	23073588	2012
6	Mixed epithelial and stromal tumor of the kidney: radiologic-pathologic correlation. ⁶¹	Chu LC...Fishman EK	21071374	2010
7	Adult cystic nephroma: a case report and a review of the literature. ⁶¹	Kuzgunbay B...Kilinc F	18555707	2009
8	[Clinicopathologic analysis of mixed epithelial and stromal tumor of kidney and adult cystic nephroma]. ⁶¹	Xiang H...Zhu XZ	19781188	2009
9	Adult cystic nephroma and mixed epithelial and stromal tumor of the kidney are the same disease entity: molecular and histologic evidence. ⁶¹	Zhou M...Teh BT	18971776	2009
10	Adult cystic nephroma and mixed epithelial and stromal tumor of the kidney: clinical, radiographic, and pathologic characteristics. ⁶¹	Lane BR...Zhou M	18313107	2008
11	Malignant mixed epithelial and stromal tumor of the kidney with rhabdoid features: report of a case including immunohistochemical, molecular genetic studies and comparison to morphologically similar renal tumors. ⁶¹	Sukov WR...Lewin M	17707262	2007
12	Cystic nephroma (multilocular cyst) and mixed epithelial and stromal tumor of the kidney: a spectrum of the same entity? ⁶¹	Jevremovic D...Lewin M	16546041	2006

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Genes for Adult Cystic Nephroma

Genes related to Adult Cystic Nephroma (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	PGR	Progesterone Receptor	Protein Coding	12.08	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
2	MME	Membrane Metalloendopeptidase	Protein Coding	10.97	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
3	KIT	KIT Proto-Oncogene, Receptor Tyrosine Kinase	Protein Coding	10.2	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
4	MEST	Mesoderm Specific Transcript	Protein Coding	7.97	DISEASES inferred ¹⁵
5	ACTC1	Actin Alpha Cardiac Muscle 1	Protein Coding	6.66	GeneCards inferred via : Publications (show sections)
6	DES	Desmin	Protein Coding	6.66	GeneCards inferred via : Publications (show sections)

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Variations for Adult Cystic Nephroma

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Expression for Adult Cystic Nephroma

Search GEO for disease gene expression data for Adult Cystic Nephroma.

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Pathways for Adult Cystic Nephroma

Pathways related to Adult Cystic Nephroma according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Mesenchymal Stem Cells and Lineage-specific Markers ⁶⁴	11.23	KIT DES
2	Dendritic Cells Developmental Lineage Pathway ⁶⁴	11.02	MME KIT
3	Striated Muscle Contraction ⁶⁵ ¹	10.81	DES ACTC1
4	Cardiac Progenitor Differentiation ¹	10.35	KIT ACTC1

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GO Terms for Adult Cystic Nephroma

Biological processes related to Adult Cystic Nephroma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	muscle filament sliding	GO:0030049	8.62	DES ACTC1

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