MCID: ADL027
MIFTS: 31

Adult Dermatomyositis

Categories: Bone diseases, Muscle diseases, Nephrological diseases, Neuronal diseases, Rare diseases, Skin diseases

Aliases & Classifications for Adult Dermatomyositis

MalaCards integrated aliases for Adult Dermatomyositis:

Name: Adult Dermatomyositis 12 15
Adult Onset Dermatomyositis 12
Adult Type Dermatomyositis 70

Classifications:



External Ids:

Disease Ontology 12 DOID:14202
UMLS 70 C0221056

Summaries for Adult Dermatomyositis

MalaCards based summary : Adult Dermatomyositis, also known as adult onset dermatomyositis, is related to subacute cutaneous lupus erythematosus and childhood type dermatomyositis. An important gene associated with Adult Dermatomyositis is MORC3 (MORC Family CW-Type Zinc Finger 3), and among its related pathways/superpathways are Measles and Tuberculosis. The drugs Antidotes and Chelating Agents have been mentioned in the context of this disorder. Affiliated tissues include skin, heart and lung.

Related Diseases for Adult Dermatomyositis

Diseases in the Dermatomyositis family:

Adult Dermatomyositis

Diseases related to Adult Dermatomyositis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 160)
# Related Disease Score Top Affiliating Genes
1 subacute cutaneous lupus erythematosus 29.9 TRIM21 TNF
2 childhood type dermatomyositis 29.8 TRIM33 TRIM24 TRIM21 TNF MORC3 ISG15
3 myositis 29.8 TRIM33 TRIM21 TNF IFNA1 IFIH1
4 interstitial lung disease 29.8 TRIM21 TNF MORC3 IFIH1
5 exanthem 29.6 TRIM21 TNF IFNA1 IFIH1 GPT
6 cutaneous lupus erythematosus 29.5 TRIM21 TNF IFNA1
7 muscular disease 29.5 TRIM33 TNF MORC3 IFIH1
8 systemic lupus erythematosus 28.8 TRIM21 TNF MBL2 ISG15 IFNA1 IFIH1
9 autoimmune disease 28.7 VDR TRIM21 TNF MBL2 IFNA1 IFIH1
10 dermatomyositis 11.4
11 calcinosis 10.4
12 vulvar vestibulitis syndrome 10.3 TNF MBL2
13 myopathy 10.3
14 critical illness polyneuropathy 10.3 TNF GPT
15 gastrointestinal tuberculosis 10.3 TNF GPT
16 granulomatous hepatitis 10.3 TNF GPT
17 polymyositis 10.3
18 coronary aneurysm 10.3 TNF GPT
19 abdominal tuberculosis 10.3 TNF GPT
20 heart aneurysm 10.3 TNF GPT
21 orbital plasma cell granuloma 10.3 TRIM33 MORC3
22 chronic orbital inflammation 10.3 TRIM33 MORC3
23 hemorrhoid 10.3 TNF GPT
24 african tick-bite fever 10.3 TNF GPT
25 compartment syndrome 10.2 TNF GPT
26 cecal disease 10.2 TNF GPT
27 nasopharyngitis 10.2 TNF GPT
28 opisthorchiasis 10.2 TNF GPT
29 tularemia 10.2 TNF MBL2
30 bronchopneumonia 10.2 TNF GPT
31 multidrug-resistant tuberculosis 10.2 VDR TNF
32 intestinal perforation 10.2 TNF GPT
33 dysphagia 10.2
34 null-cell leukemia 10.2 TNF IFNA1
35 drug-induced hepatitis 10.2 TNF GPT
36 skin sarcoidosis 10.2 TNF IFNA1
37 mononeuritis of upper limb and mononeuritis multiplex 10.2 TRIM21 TNF
38 mononeuritis multiplex 10.2 TRIM21 TNF
39 superficial basal cell carcinoma 10.2 TNF IFNA1
40 acute kidney tubular necrosis 10.2 TNF GPT
41 connective tissue disease 10.2
42 trachoma 10.2 TNF MBL2
43 mononeuropathy 10.1 TRIM21 TNF
44 macs syndrome 10.1 TNF IFNA1
45 kawasaki disease 10.1 TNF MBL2 GPT
46 salmonellosis 10.1 VDR TNF GPT
47 pulmonary tuberculosis 10.1 VDR TNF MBL2
48 swine influenza 10.1 TNF IFNA1
49 vasculitis 10.1
50 aspiration pneumonia 10.1 TNF GPT

Graphical network of the top 20 diseases related to Adult Dermatomyositis:



Diseases related to Adult Dermatomyositis

Symptoms & Phenotypes for Adult Dermatomyositis

Drugs & Therapeutics for Adult Dermatomyositis

Drugs for Adult Dermatomyositis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 10)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Antidotes Phase 2
2 Chelating Agents Phase 2
3 Antioxidants Phase 2
4 Protective Agents Phase 2
5 sodium thiosulfate Phase 2
6 Anti-Infective Agents Phase 2
7 Anti-Bacterial Agents Phase 2
8 Calcium, Dietary Phase 2
9 Antitubercular Agents Phase 2
10
Calcium Nutraceutical Phase 2 7440-70-2 271

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 An Open-label Study of Sodium Thiosulfate for Treatment of Calcinosis Associated With Juvenile and Adult Dermatomyositis Recruiting NCT03267277 Phase 2 Sodium Thiosulfate

Search NIH Clinical Center for Adult Dermatomyositis

Genetic Tests for Adult Dermatomyositis

Anatomical Context for Adult Dermatomyositis

MalaCards organs/tissues related to Adult Dermatomyositis:

40
Skin, Heart, Lung, Skeletal Muscle, Endothelial, Kidney, Thyroid

Publications for Adult Dermatomyositis

Articles related to Adult Dermatomyositis:

(show top 50) (show all 153)
# Title Authors PMID Year
1
Association of anti-NXP2 antibody with clinical characteristics and outcomes in adult dermatomyositis: results from clinical applications based on a myositis-specific antibody. 61
33712891 2021
2
Morphological characteristics of the transition from juvenile to adult dermatomyositis. 61
32686124 2020
3
Up-to-date treatment and management of myositis. 61
32890030 2020
4
Macrophage activation syndrome in adult dermatomyositis: a case-based review. 61
32356114 2020
5
A Clinically and Biologically Based Subclassification of the Idiopathic Inflammatory Myopathies Using Machine Learning. 61
32039563 2020
6
Nuclear matrix protein 2 antibody-positive adult dermatomyositis: a case report and review of the literature. 61
32609448 2020
7
[Dermatomyositis: new antibody, new classification]. 61
31859626 2019
8
Clinical significance of subcutaneous fat and fascial involvement in juvenile dermatomyositis. 61
30092673 2019
9
The IgG2 Isotype of Anti-Transcription Intermediary Factor 1γ Autoantibodies Is a Biomarker of Cancer and Mortality in Adult Dermatomyositis. 61
30896088 2019
10
Recent Advances in Pharmacological Treatments of Adult Dermatomyositis. 61
31473845 2019
11
Frequency and clinical relevance of anti-Mi-2 autoantibody in adult Brazilian patients with dermatomyositis. 61
31266544 2019
12
Interferon Chemokine Score and Other Cytokine Measures Track With Changes in Disease Activity in Patients With Juvenile and Adult Dermatomyositis. 61
31777784 2019
13
Extensive calcinosis in adult dermatomyositis. 61
28396153 2019
14
Use of Anti-transcriptional Intermediary Factor-1 Gamma Autoantibody in Identifying Adult Dermatomyositis Patients with Cancer: A Systematic Review and Meta-analysis. 61
30460368 2019
15
Biomarkers in Adult Dermatomyositis: Tools to Help the Diagnosis and Predict the Clinical Outcome. 61
30766892 2019
16
Comparison between treatment naive juvenile and adult dermatomyositis muscle biopsies: difference of inflammatory cells phenotyping. 61
30657098 2018
17
Prevalence and predictors of asymptomatic vertebral fractures in inflammatory myositis. 61
29314651 2018
18
Abatacept in the treatment of adult dermatomyositis and polymyositis: a randomised, phase IIb treatment delayed-start trial. 61
28993346 2018
19
Cutaneous and Systemic Findings Associated With Nuclear Matrix Protein 2 Antibodies in Adult Dermatomyositis Patients. 61
28129490 2017
20
A case of adult dermatomyositis associated with parainfluenza virus infection and Jo-1 antibody. 61
24341326 2017
21
2016 ACR-EULAR adult dermatomyositis and polymyositis and juvenile dermatomyositis response criteria-methodological aspects. 61
28977549 2017
22
Evaluation of the reliability of the Cutaneous Dermatomyositis Disease Area and Severity Index and the Cutaneous Assessment Tool-Binary Method in juvenile dermatomyositis among paediatric dermatologists, rheumatologists and neurologists. 61
28421601 2017
23
Environmental factors associated with disease flare in juvenile and adult dermatomyositis. 61
28444299 2017
24
2016 American College of Rheumatology/European League Against Rheumatism Criteria for Minimal, Moderate, and Major Clinical Response in Adult Dermatomyositis and Polymyositis: An International Myositis Assessment and Clinical Studies Group/Paediatric Rheumatology International Trials Organisation Collaborative Initiative. 61
28382787 2017
25
2016 American College of Rheumatology/European League Against Rheumatism criteria for minimal, moderate, and major clinical response in adult dermatomyositis and polymyositis: An International Myositis Assessment and Clinical Studies Group/Paediatric Rheumatology International Trials Organisation Collaborative Initiative. 61
28385805 2017
26
MDA5 autoantibody-another indicator of clinical diversity in dermatomyositis. 61
28480196 2017
27
Liposteroid therapy for juvenile and adult dermatomyositis: efficacy and side effects. 61
28361075 2017
28
Clinical characteristics of anti-SAE antibodies in Chinese patients with dermatomyositis in comparison with different patient cohorts. 61
28298642 2017
29
[Infrapatellar hypertrichosis in adult dermatomyositis]. 61
27765415 2017
30
Gene Expression Profiling in Blood and Affected Muscle Tissues Reveals Differential Activation Pathways in Patients with New-onset Juvenile and Adult Dermatomyositis. 61
27803134 2017
31
Anti-TIF1-γ-positive young adult dermatomyositis with germ cell tumour. 61
27457276 2016
32
Recent advances in dermatomyositis-specific autoantibodies. 61
27533321 2016
33
Universalis Calcinosis in Adult Dermatomyositis: An "Anti-NXP2 Syndrome". 61
27660942 2016
34
Association of vitamin D receptor gene BsmI B/b and FokI F/f polymorphisms with adult dermatomyositis and systemic lupus erythematosus. 61
26972080 2016
35
[New insights of myositis-specific and -associated autoantibodies in juvenile and adult type myositis]. 61
27452067 2016
36
Gastrointestinal endarteropathy in adult dermatomyositis. 61
26184526 2016
37
Differential roles of hypoxia and innate immunity in juvenile and adult dermatomyositis. 61
27121733 2016
38
Adult dermatomyositis associated with benign ovarian teratoma: A case report. 61
27073526 2016
39
Colonic vasculopathy and perforation in the initial presentation of adult dermatomyositis in a patient with improving muscle weakness. 61
26759443 2016
40
MicroRNA-10a Regulation of Proinflammatory Mediators: An Important Component of Untreated Juvenile Dermatomyositis. 61
26628598 2016
41
Severe adult dermatomyositis with unusual calcinosis. 61
26286744 2015
42
Genome-wide association study identifies HLA 8.1 ancestral haplotype alleles as major genetic risk factors for myositis phenotypes. 61
26291516 2015
43
[Clinical features of patients with juvenile and adult dermatomyositis]. 61
26552025 2015
44
Clinico pathological study of adult dermatomyositis: Importance of muscle histology in the diagnosis. 61
26019418 2015
45
Autoantibodies to DNA mismatch repair enzymes in polymyositis/dermatomyositis and other autoimmune diseases: a possible marker of favorable prognosis. 61
25186186 2014
46
A case of adult dermatomyositis with calcinosis universalis. 61
25400376 2014
47
Paraneoplastic dermatomyositis: a study of 12 cases. 61
24484630 2014
48
HLA class II alleles may influence susceptibility to adult dermatomyositis and polymyositis in a Han Chinese population. 61
24894810 2014
49
MBL2 polymorphisms - manifestations in Bulgarian patients with adult dermatomyositis and systemic lupus erythematosus. 61
24103065 2014
50
Predictors of clinical improvement in rituximab-treated refractory adult and juvenile dermatomyositis and adult polymyositis. 61
24574235 2014

Variations for Adult Dermatomyositis

Expression for Adult Dermatomyositis

Search GEO for disease gene expression data for Adult Dermatomyositis.

Pathways for Adult Dermatomyositis

GO Terms for Adult Dermatomyositis

Biological processes related to Adult Dermatomyositis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 defense response to virus GO:0051607 9.33 ISG15 IFNA1 IFIH1
2 protein ubiquitination GO:0016567 9.02 TRIM33 TRIM24 TRIM21 SAE1 ISG15
3 negative regulation of type I interferon production GO:0032480 8.96 ISG15 IFIH1

Molecular functions related to Adult Dermatomyositis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 zinc ion binding GO:0008270 9.1 VDR TRIM33 TRIM24 TRIM21 MORC3 IFIH1

Sources for Adult Dermatomyositis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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