MCID: ADL027
MIFTS: 39

Adult Dermatomyositis

Categories: Bone diseases, Eye diseases, Muscle diseases, Nephrological diseases, Neuronal diseases, Rare diseases, Respiratory diseases, Skin diseases

Aliases & Classifications for Adult Dermatomyositis

MalaCards integrated aliases for Adult Dermatomyositis:

Name: Adult Dermatomyositis 12 15
Adult Onset Dermatomyositis 12
Adult Type Dermatomyositis 73

Classifications:



External Ids:

Disease Ontology 12 DOID:14202
UMLS 73 C0221056

Summaries for Adult Dermatomyositis

MalaCards based summary : Adult Dermatomyositis, also known as adult onset dermatomyositis, is related to viral infectious disease and dermatomyositis. An important gene associated with Adult Dermatomyositis is MBL2 (Mannose Binding Lectin 2), and among its related pathways/superpathways are Tuberculosis and Dendritic Cells Developmental Lineage Pathway. The drugs Pirfenidone and Abatacept have been mentioned in the context of this disorder. Affiliated tissues include skin, bone and eye, and related phenotype is homeostasis/metabolism.

Related Diseases for Adult Dermatomyositis

Diseases in the Dermatomyositis family:

Adult Dermatomyositis

Diseases related to Adult Dermatomyositis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 123)
# Related Disease Score Top Affiliating Genes
1 viral infectious disease 29.2 GPT TLR9 TNF
2 dermatomyositis 11.8
3 childhood type dermatomyositis 11.4
4 vulvar vestibulitis syndrome 10.2 MBL2 TNF
5 streptococcal meningitis 10.2 MBL2 TNF
6 listeriosis 10.2 MBL2 TNF
7 calcinosis 10.2
8 rheumatic fever 10.2 MBL2 TNF
9 multidrug-resistant tuberculosis 10.2 TNF VDR
10 bacterial vaginosis 10.2 MBL2 TNF
11 rheumatic heart disease 10.2 MBL2 TNF
12 rosacea 10.2 TNF VDR
13 lepromatous leprosy 10.2 TNF VDR
14 prostatitis 10.2 TNF VDR
15 extrapulmonary tuberculosis 10.1 MBL2 VDR
16 compartment syndrome 10.1 CHKB TNF
17 endometritis 10.1 CHKB TNF
18 polymyositis 10.1
19 opisthorchiasis 10.1 GPT TNF
20 nonalcoholic steatohepatitis 10.1 GPT TNF
21 hemorrhagic fever 10.1 GPT TNF
22 scrub typhus 10.1 GPT TNF
23 protein-energy malnutrition 10.1 GPT TNF
24 cerebral palsy 10.1 MBL2 TNF
25 hepatitis e 10.1 GPT TNF
26 otitis media 10.1 MBL2 TNF
27 hepatitis a 10.1 GPT TNF
28 obstructive jaundice 10.1 GPT TNF
29 hepatic encephalopathy 10.1 GPT TNF
30 alcoholic hepatitis 10.1 GPT TNF
31 portal hypertension 10.0 GPT TNF
32 mucocutaneous leishmaniasis 10.0 TLR9 TNF
33 cutaneous leishmaniasis 10.0 TLR9 TNF
34 central nervous system vasculitis 10.0 TLR9 TNF
35 cholangitis 10.0 GPT TNF
36 autoimmune disease of eyes, ear, nose and throat 10.0 TLR9 TNF
37 hypersensitivity reaction type iii disease 10.0 TLR9 TNF
38 lichen disease 10.0 TLR9 TNF
39 coccidiosis 10.0 TLR9 TNF
40 middle ear disease 10.0 TLR9 TNF
41 lacrimal apparatus disease 10.0 TLR9 TNF
42 hypersensitivity reaction type iv disease 10.0 TLR9 TNF
43 perinatal necrotizing enterocolitis 10.0 TLR9 TNF
44 meningococcal meningitis 10.0 MBL2 TLR9
45 exanthem 10.0 TLR9 TNF
46 keratoconjunctivitis sicca 10.0 TLR9 TNF
47 keratoconjunctivitis 10.0 TLR9 TNF
48 extrinsic cardiomyopathy 10.0 TLR9 TNF
49 lymph node disease 10.0 TLR9 TNF
50 cryptococcosis 10.0 MBL2 TLR9

Graphical network of the top 20 diseases related to Adult Dermatomyositis:



Diseases related to Adult Dermatomyositis

Symptoms & Phenotypes for Adult Dermatomyositis

MGI Mouse Phenotypes related to Adult Dermatomyositis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.1 CHKB DMBX1 MBL2 TLR9 TNF VDR

Drugs & Therapeutics for Adult Dermatomyositis

Drugs for Adult Dermatomyositis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 134)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Pirfenidone Approved, Investigational Phase 4 53179-13-8 40632
2
Abatacept Approved Phase 4,Phase 3,Phase 2 332348-12-6 10237
3 Anti-Inflammatory Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
4 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
5 Analgesics Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
6 Antirheumatic Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
7 Analgesics, Non-Narcotic Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
8 Anti-Inflammatory Agents, Non-Steroidal Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
9 Immunologic Factors Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
10 Vaccines Phase 4,Not Applicable
11 beta-endorphin Phase 4,Phase 2
12 Hormones Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
13 Melanocyte-Stimulating Hormones Phase 4,Phase 2
14 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
15 Adrenocorticotropic Hormone Phase 4,Phase 2
16 Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
17 Immunosuppressive Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
18
Prednisone Approved, Vet_approved Phase 3,Phase 2,Not Applicable 53-03-2 5865
19
Prednisolone phosphate Approved, Vet_approved Phase 3,Phase 2 302-25-0
20
Miconazole Approved, Investigational, Vet_approved Phase 3,Phase 2 22916-47-8 4189
21
Prednisolone Approved, Vet_approved Phase 3,Phase 2 50-24-8 5755
22
Methylprednisolone Approved, Vet_approved Phase 3,Phase 2 83-43-2 6741
23
Methylprednisolone hemisuccinate Approved Phase 3,Phase 2 2921-57-5
24
Methotrexate Approved Phase 3,Phase 2 59-05-2, 1959-05-2 126941
25
Levoleucovorin Approved, Investigational Phase 3,Phase 2 68538-85-2
26
leucovorin Approved Phase 3,Phase 2 58-05-9 6006 143
27
Tacrolimus Approved, Investigational Phase 2, Phase 3 104987-11-3 445643 439492
28
Benzocaine Approved, Investigational Phase 2, Phase 3 94-09-7, 1994-09-7 2337
29 tannic acid Approved Phase 2, Phase 3
30
Alendronate Approved Phase 2, Phase 3 66376-36-1, 121268-17-5 2088
31
Infliximab Approved Phase 2, Phase 3 170277-31-3
32
Cyclophosphamide Approved, Investigational Phase 2, Phase 3,Phase 1 6055-19-2, 50-18-0 2907
33
rituximab Approved Phase 2, Phase 3 174722-31-7 10201696
34
Etanercept Approved, Investigational Phase 2, Phase 3,Phase 1 185243-69-0
35
belimumab Approved Phase 2, Phase 3 356547-88-1 5957 10451420
36
Acetylcysteine Approved, Investigational Phase 2, Phase 3 616-91-1 12035
37
Folic Acid Approved, Nutraceutical, Vet_approved Phase 3,Phase 2 59-30-3 6037
38
Prednisolone hemisuccinate Experimental Phase 3,Phase 2 2920-86-7
39 Nucleic Acid Synthesis Inhibitors Phase 3,Phase 2
40 Methylprednisolone acetate Phase 3,Phase 2
41 Antineoplastic Agents, Hormonal Phase 3,Phase 2,Not Applicable
42 Antimetabolites, Antineoplastic Phase 3,Phase 2
43 Calcineurin Inhibitors Phase 3,Phase 2
44 Prednisolone acetate Phase 3,Phase 2
45 Vitamin B9 Phase 3,Phase 2
46 Cyclosporins Phase 3,Phase 2
47 Vitamin B Complex Phase 3,Phase 2
48 Antifungal Agents Phase 3,Phase 2
49 Folate Phase 3,Phase 2
50 Gastrointestinal Agents Phase 3,Phase 2,Phase 1

Interventional clinical trials:

(show top 50) (show all 98)
# Name Status NCT ID Phase Drugs
1 Pirfenidone in Progressive Interstitial Lung Disease Associated With Clinically Amyopathic Dermatomyositis Unknown status NCT02821689 Phase 4 Pirfenidone
2 Safety and Efficacy of Anti-Pandemic H1N1 Vaccination in Rheumatic Diseases Unknown status NCT01151644 Phase 4
3 Immune Response After Human Papillomavirus Vaccination in Patients With Autoimmune Disease Completed NCT00815282 Phase 4
4 MP Diagnostics HTLV Blot 2.4 Post-Market Clinical Study Completed NCT03226119 Phase 4
5 Efficacy and Safety of H.P. Acthar Gel for the Treatment of Refractory Cutaneous Manifestations of Dermatomyositis Recruiting NCT02245841 Phase 4 H.P. Acthar Gel
6 Abatacept in Juvenile Dermatomyositis Recruiting NCT02594735 Phase 4 Abatacept
7 Five-year Actively Controlled Clinical Trial in New Onset Juvenile Dermatomyositis Unknown status NCT00323960 Phase 3 3 MPDN pulse + PDN;3 MPDN pulse + PDN + CSA;3 MPDN pulse + PDN + MTX
8 Efficacy and Safety Study of GB-0998 for Treatment of Steroid-resistant Polymyositis and Dermatomyositis (PM/DM) Completed NCT00335985 Phase 3 GB-0998;Placebo of GB-0998
9 Combined Treatment of Methotrexate + Glucocorticoids Versus Glucocorticoids Alone in Patients With PM and DM Completed NCT00651040 Phase 3 Prednisone;Methotrexate
10 Investigation in Myositis-associated Pneumonitis of Prednisolone And Concomitant Tacrolimus Completed NCT00504348 Phase 2, Phase 3 Tacrolimus
11 Alendronate Osteoporosis Study Completed NCT00277251 Phase 2, Phase 3 Alendronate
12 Anakinra in Myositis Completed NCT01165008 Phase 2, Phase 3 Anakinra
13 Treatment With TNF Blockade, Infliximab, in Patients With Myositis Completed NCT00443222 Phase 2, Phase 3 Infliximab
14 Trial to Evaluate Efficacy and Safety of Lenabasum in Dermatomyositis Recruiting NCT03813160 Phase 3 Lenabasum 20 mg;Lenabasum 5 mg;Placebo
15 Study Evaluating Efficacy and Safety of Octanorm in Patients With Dermatomyositis Recruiting NCT03686969 Phase 3 Octanorm
16 Rituximab Versus Cyclophosphamide in Connective Tissue Disease-ILD Recruiting NCT01862926 Phase 2, Phase 3 Rituximab;Cyclophosphamide
17 Trial to Evaluate the Efficacy and Safety of Abatacept in Combination With Standard Therapy Compared to Standard Therapy Alone in Improving Disease Activity in Adults With Active Idiopathic Inflammatory Myopathy Recruiting NCT02971683 Phase 3 Abatacept subcutaneous;Placebo
18 Belimumab in Idiopathic Inflammatory Myositis Recruiting NCT02347891 Phase 2, Phase 3 Belimumab;Placebo
19 Study Evaluating Efficacy and Safety of Octagam 10% in Patients With Dermatomyositis (Idiopathic Inflammatory Myopathy) Active, not recruiting NCT02728752 Phase 3 Octagam 10%
20 Understanding the Pathogenesis and Treatment of Childhood Onset Dermatomyositis Terminated NCT00035958 Phase 2, Phase 3 Prednisone;Methotrexate;Etanercept
21 A Clinical Trial for CTD-ILD Treatment Terminated NCT01424033 Phase 2, Phase 3 N-Acetylcysteine
22 Abatacept Treatment in Polymyositis and Dermatomyositis Unknown status NCT01315938 Phase 2 Abatacept;Abatacept
23 Topical Sodium Thiosulfate and Fractional Carbon Dioxide Laser in Treating Dermatomyositis Associated Calcinosis Completed NCT01572844 Phase 2 Sodium thiosulfate
24 Acthar in Treatment of Refractory Dermatomyositis and Polymyositis Completed NCT01906372 Phase 2 Adrenocorticotropic Hormone Gel
25 Safety and Effectiveness of h5G1.1-mAb for Dermatomyositis Completed NCT00005571 Phase 2 h5G1.1-mAb
26 Efficacy of an Individual Rehabilitation Program in Polymyositis and Dermatomyositis Completed NCT01415219 Phase 2
27 Methimazole to Treat Polymyositis and Dermatomyositis Completed NCT00001421 Phase 2 methimazole
28 Infliximab (Remicade ) to Treat Dermatomyositis and Polymyositis Completed NCT00033891 Phase 2 Infliximab
29 Absorption of Corticosteroids in Children With Juvenile Dermatomyositis Completed NCT00004357 Phase 2 Methylprednisolone;Prednisolone
30 Rituximab for the Treatment of Refractory Adult and Juvenile Dermatomyositis (DM) and Adult Polymyositis (PM) Completed NCT00106184 Phase 2 Rituximab;Placebo
31 Intravenousimmunoglobulin (IVIg) for the Treatment of Inflammatory Myopathies Completed NCT00001261 Phase 2 Gamma Globulin
32 A Study to Evaluate the Long-Term Safety of MEDI-545 in Adult Participants With Systemic Lupus Erythematosus or Myositis Completed NCT00979654 Phase 2 Sifalimumab
33 Evaluating Safety & Efficacy of Apremilast in the Treatment of Cutaneous Disease in Patients With Recalcitrant Dermatomyositis Recruiting NCT03529955 Phase 2 Apremilast 30mg
34 Sodium Thiosulfate for Treatment of Calcinosis Associated With Juvenile and Adult Dermatomyositis Recruiting NCT03267277 Phase 2 Sodium Thiosulfate
35 A Study In Adults With Moderate To Severe Dermatomyositis Recruiting NCT03181893 Phase 2 PF-06823859;Placebo Arm
36 Study of IFN-K in Dermatomyositis Recruiting NCT02980198 Phase 2
37 Tocilizumab in the Treatment of Refractory Polymyositis and Dermatomyositis Recruiting NCT02043548 Phase 2 tocilizumab;placebo
38 Safety, Tolerability, and Efficacy of JBT-101 in Subjects With Dermatomyositis Active, not recruiting NCT02466243 Phase 2 JBT-101;Placebo
39 Trial of IMO-8400 in Adult Patients With Dermatomyositis Active, not recruiting NCT02612857 Phase 2 IMO-8400 Dose Group 1;IMO-8400 Dose Group 2;Placebo
40 Basiliximab Treating Interstitial Pneumonia of CADM Not yet recruiting NCT03192657 Phase 2 Basiliximab;Calcineurin Inhibitors;Steroids
41 Intralesional Sodium Thiosulfate for Ectopic Calcifications or Ossifications. A Pilot Study Not yet recruiting NCT03582800 Phase 2 STS
42 Denosumab for Glucocorticoid-treated Children With Rheumatic Disorders Not yet recruiting NCT02418273 Phase 1, Phase 2 denosumab
43 Safety and Efficacy of BAF312 in Dermatomyositis Terminated NCT02029274 Phase 2 BAF312;Placebo
44 Efficacy and Tolerability of BAF312 in Patients With Polymyositis and Dermatomyositis Terminated NCT01148810 Phase 2 BAF312;Placebo
45 A Pilot Study to Evaluate Topical Sodium Thiosulfate Therapy for Calcinosis Cutis Withdrawn NCT01918904 Phase 2 Sodium thiosulfate;Placebo
46 Evaluation of the Safety and Effectiveness of Tailored Transoral Incisionless Fundoplication (TIF) Using EsophyX for the Treatment of GERD Withdrawn NCT01025739 Phase 2
47 A Pilot Study of Etanercept in Dermatomyositis Completed NCT00112385 Phase 1 Etanercept;Placebo
48 A Study to Evaluate Safety of Multi-Dose MEDI-545 in Adult Patients With Dermatomyositis or Polymyositis Completed NCT00533091 Phase 1
49 A Phase 1 Study of MEDI7734 in Type I Interferon-Mediated Autoimmune Diseases Completed NCT02780674 Phase 1
50 Pilot Study of Total Body Irradiation in Combination With Cyclophosphamide, Anti-thymocyte Globulin, and Autologous CD34-Selected Peripheral Blood Stem Cell Transplantation in Children With Refractory Autoimmune Disorders Completed NCT00010335 Phase 1

Search NIH Clinical Center for Adult Dermatomyositis

Genetic Tests for Adult Dermatomyositis

Anatomical Context for Adult Dermatomyositis

MalaCards organs/tissues related to Adult Dermatomyositis:

41
Skin, Bone, Eye, Lung, Heart, Lymph Node, Prostate

Publications for Adult Dermatomyositis

Articles related to Adult Dermatomyositis:

(show top 50) (show all 90)
# Title Authors Year
1
Abatacept in the treatment of adult dermatomyositis and polymyositis: a randomised, phase IIb treatment delayed-start trial. ( 28993346 )
2018
2
Use of Anti-transcriptional Intermediary Factor-1 Gamma Autoantibody in Identifying Adult Dermatomyositis Patients with Cancer: A Systematic Review and Meta-analysis. ( 30460368 )
2018
3
Association of antinuclear antibody status with clinical features and malignancy risk in adult-onset dermatomyositis. ( 30458207 )
2018
4
Acquired Partial Lipodystrophy Associated with Anti-Mi-2 Antibody-positive Adult-onset Dermatomyositis. ( 30182133 )
2018
5
2016 American College of Rheumatology/European League Against Rheumatism criteria for minimal, moderate, and major clinical response in adult dermatomyositis and polymyositis: An International Myositis Assessment and Clinical Studies Group/Paediatric Rheumatology International Trials Organisation Collaborative Initiative. ( 28385805 )
2017
6
Environmental factors associated with disease flare in juvenile and adult dermatomyositis. ( 28444299 )
2017
7
The cutaneous and systemic findings associated with nuclear matrix protein-2 antibodies in adult dermatomyositis patients. ( 28129490 )
2017
8
Gene Expression Profiling in Blood and Affected Muscle Tissues Reveals Differential Activation Pathways in Patients with New-onset Juvenile and Adult Dermatomyositis. ( 27803134 )
2017
9
Liposteroid therapy for juvenile and adult dermatomyositis: efficacy and side effects. ( 28361075 )
2017
10
2016 ACR-EULAR adult dermatomyositis and polymyositis and juvenile dermatomyositis response criteria-methodological aspects. ( 28977549 )
2017
11
2016 American College of Rheumatology/European League Against Rheumatism Criteria for Minimal, Moderate, and Major Clinical Response in Adult Dermatomyositis and Polymyositis: An International Myositis Assessment and Clinical Studies Group/Paediatric Rheumatology International Trials Organisation Collaborative Initiative. ( 28382787 )
2017
12
Extensive calcinosis in adult dermatomyositis. ( 28396153 )
2017
13
Calcinosis universalis in adult-onset dermatomyositis. ( 27377452 )
2017
14
Association of vitamin D receptor gene BsmI B/b and FokI F/f polymorphisms with adult dermatomyositis and systemic lupus erythematosus. ( 26972080 )
2016
15
Colonic vasculopathy and perforation in the initial presentation of adult dermatomyositis in a patient with improving muscle weakness. ( 26759443 )
2016
16
Universalis Calcinosis in Adult Dermatomyositis: An "Anti-NXP2 Syndrome". ( 27660942 )
2016
17
Differential roles of hypoxia and innate immunity in juvenile and adult dermatomyositis. ( 27121733 )
2016
18
Adult dermatomyositis associated with benign ovarian teratoma: A case report. ( 27073526 )
2016
19
Anti-TIF1-γ-positive young adult dermatomyositis with germ cell tumour. ( 27457276 )
2016
20
Clinico pathological study of adult dermatomyositis: Importance of muscle histology in the diagnosis. ( 26019418 )
2015
21
Severe adult dermatomyositis with unusual calcinosis. ( 26286744 )
2015
22
Gastrointestinal endarteropathy in adult dermatomyositis. ( 26184526 )
2015
23
Calcific panniculitis and nasopharyngeal cancer-associated adult-onset dermatomyositis: a case report and literature review. ( 25977892 )
2015
24
Adult dermatomyositis with bleeding ulcer in the pharynx. ( 25328739 )
2014
25
A case of adult dermatomyositis with calcinosis universalis. ( 25400376 )
2014
26
IL-1RN VNTR Polymorphism in Adult Dermatomyositis and Systemic Lupus Erythematosus. ( 25328514 )
2014
27
HLA class II alleles may influence susceptibility to adult dermatomyositis and polymyositis in a Han Chinese population. ( 24894810 )
2014
28
Unusual sequelae of adult-onset dermatomyositis. ( 25085949 )
2014
29
Analysis of metabolic syndrome in adult dermatomyositis with a focus on cardiovascular disease. ( 23139205 )
2013
30
Adult dermatomyositis associated with lipodystrophy. ( 23962582 )
2013
31
Focal lipodystrophy without metabolic disorders in adult dermatomyositis. ( 22804743 )
2013
32
Lacy reticular-pattern calcinosis in adult dermatomyositis. ( 23908532 )
2013
33
Therapy of calcinosis universalis complicating adult dermatomyositis. ( 24131911 )
2013
34
A case of adult dermatomyositis associated with parainfluenza virus infection and Jo-1 antibody. ( 24341326 )
2013
35
Renal cell carcinoma-associated adult dermatomyositis treated laparoscopic nephrectomy. ( 24311917 )
2013
36
MBL2 polymorphisms - manifestations in bulgarian patients with adult dermatomyositis and systemic lupus erythematosus. ( 24103065 )
2013
37
Association of TNF-I+ polymorphisms with adult dermatomyositis and systemic lupus erythematosus in Bulgarian patients. ( 22913362 )
2012
38
Changes in novel biomarkers of disease activity in juvenile and adult dermatomyositis are sensitive biomarkers of disease course. ( 22886447 )
2012
39
Marked improvement of calcinosis in adult dermatomyositis with etidronate therapy. ( 21710176 )
2012
40
Adult dermatomyositis: experience of a Brazilian tertiary care center. ( 23223700 )
2012
41
Clinical features, pathogenesis and treatment of juvenile and adult dermatomyositis. ( 21947177 )
2011
42
Adult dermatomyositis with severe polyneuropathy: does neuromyositis exist? ( 20229079 )
2010
43
An extremely severe case of cutaneous calcinosis complicating adult dermatomyositis. ( 19076816 )
2009
44
Clinical characteristics and outcomes of juvenile and adult dermatomyositis. ( 19654958 )
2009
45
Case of pneumatosis cystoides intestinalis in adult dermatomyositis. ( 18181780 )
2008
46
Tracheoesophageal fistula: a rare complication of adult dermatomyositis. ( 18474474 )
2008
47
Calcinosis cutis: a rare feature of adult dermatomyositis. ( 18319027 )
2008
48
Acute-onset adult dermatomyositis presenting with erythroderma and diplopia. ( 17868397 )
2007
49
Lipodystrophy and metabolic abnormalities in a case of adult dermatomyositis. ( 17938031 )
2007
50
Difference in adhesion molecule expression (ICAM-1 and VCAM-1) in juvenile and adult dermatomyositis, polymyositis and inclusion body myositis. ( 16431335 )
2006

Variations for Adult Dermatomyositis

Expression for Adult Dermatomyositis

Search GEO for disease gene expression data for Adult Dermatomyositis.

Pathways for Adult Dermatomyositis

Pathways related to Adult Dermatomyositis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.38 TLR9 TNF VDR
2 11.24 TLR9 TNF
3 11.01 TLR9 TNF
4 10.91 TNF VDR
5 10.7 TLR9 TNF
6 9.77 TNF VDR

GO Terms for Adult Dermatomyositis

Biological processes related to Adult Dermatomyositis according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 9.69 TLR9 TNF VDR
2 positive regulation of JNK cascade GO:0046330 9.54 TLR9 TNF
3 defense response to bacterium GO:0042742 9.54 MBL2 TLR9 TNF
4 positive regulation of inflammatory response GO:0050729 9.52 TLR9 TNF
5 I-kappaB kinase/NF-kappaB signaling GO:0007249 9.49 TLR9 TNF
6 positive regulation of interleukin-6 production GO:0032755 9.48 TLR9 TNF
7 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.46 TLR9 TNF
8 positive regulation of JUN kinase activity GO:0043507 9.43 TLR9 TNF
9 positive regulation of phagocytosis GO:0050766 9.4 MBL2 TNF
10 negative regulation of interleukin-6 production GO:0032715 9.32 TLR9 TNF
11 positive regulation of interleukin-8 production GO:0032757 9.26 TLR9 TNF
12 positive regulation of chemokine production GO:0032722 9.16 TLR9 TNF
13 negative regulation of growth of symbiont in host GO:0044130 8.96 MBL2 TNF
14 positive regulation of interleukin-8 biosynthetic process GO:0045416 8.62 TLR9 TNF

Molecular functions related to Adult Dermatomyositis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 RNA polymerase II regulatory region sequence-specific DNA binding GO:0000977 8.8 DMBX1 TNF VDR

Sources for Adult Dermatomyositis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
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45 MESH via Orphanet
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55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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