MCID: ADL019
MIFTS: 30

Adult Fibrosarcoma

Categories: Bone diseases, Cancer diseases, Rare diseases

Aliases & Classifications for Adult Fibrosarcoma

MalaCards integrated aliases for Adult Fibrosarcoma:

Name: Adult Fibrosarcoma 12 15 70

Classifications:



External Ids:

Disease Ontology 12 DOID:3516
NCIt 50 C7809
UMLS 70 C0278595

Summaries for Adult Fibrosarcoma

MalaCards based summary : Adult Fibrosarcoma is related to ring chromosome and monophasic synovial sarcoma. An important gene associated with Adult Fibrosarcoma is NTRK3 (Neurotrophic Receptor Tyrosine Kinase 3), and among its related pathways/superpathways is Mesenchymal Stem Cell Differentiation Pathways and Lineage-specific Markers. The drugs Etoposide and Ifosfamide have been mentioned in the context of this disorder. Affiliated tissues include bone and liver, and related phenotype is normal.

Related Diseases for Adult Fibrosarcoma

Diseases in the Fibrosarcoma family:

Adult Fibrosarcoma Congenital Fibrosarcoma

Diseases related to Adult Fibrosarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 138)
# Related Disease Score Top Affiliating Genes
1 ring chromosome 29.9 ETV6 CREB3L2
2 monophasic synovial sarcoma 29.7 SSX1 CD34
3 sarcoma, synovial 29.5 SSX1 MYOG CD34
4 cellular congenital mesoblastic nephroma 10.3 NTRK3 ETV6
5 congenital mesoblastic nephroma 10.3 NTRK3 ETV6
6 nephroma 10.3 NTRK3 ETV6
7 breast secretory carcinoma 10.3 NTRK3 ETV6
8 breast adenoid cystic carcinoma 10.3 NTRK3 ETV6
9 lipid-rich carcinoma 10.3 NTRK3 ETV6
10 mammary analogue secretory carcinoma 10.3 NTRK3 ETV6
11 cerebellar angioblastoma 10.2 NTRK3 ETV6
12 lung combined type small cell carcinoma 10.2 MYOG CALD1
13 kidney benign neoplasm 10.2 NTRK3 ETV6
14 fibrosarcoma 10.2
15 liposarcoma of bone 10.2 MYOG CD34
16 uterus leiomyosarcoma 10.2 MYOG CALD1
17 hobnail hemangioma 10.2 MYOG CD34
18 prostate sarcoma 10.2 MYOG CD34
19 myofibroma 10.2 CD34 CALD1
20 acinar cell carcinoma 10.1 NTRK3 ETV6
21 intravascular angioleiomyoma 10.1 CD34 CALD1
22 breast myofibroblastoma 10.1 CD34 CALD1
23 fasciitis 10.1 ETV6 CD34
24 glomangiomyoma 10.1 CD34 CALD1
25 angiomyoma 10.1 CD34 CALD1
26 vulvar leiomyosarcoma 10.1 CD34 CALD1
27 gallbladder leiomyosarcoma 10.1 CD34 CALD1
28 deep leiomyoma 10.1 CD34 CALD1
29 peritoneal benign neoplasm 10.1 CD34 CALD1
30 breast leiomyosarcoma 10.1 CD34 CALD1
31 perivascular epithelioid cell tumor 10.1 NTRK3 CALD1
32 glomangiosarcoma 10.1 CD34 CALD1
33 colon leiomyosarcoma 10.1 CD34 CALD1
34 adult malignant schwannoma 10.1 MYOG CD34
35 kidney cortex disease 10.1 NTRK3 MYOG ETV6
36 congenital fibrosarcoma 10.1 NTRK3 MYOG ETV6
37 benign perivascular tumor 10.1 CD34 CALD1
38 breast sarcoma 10.1 MYOG CD34
39 perivascular tumor 10.1 CD34 CALD1
40 small intestine leiomyoma 10.1 CD34 CALD1
41 testicular fibroma 10.1 CD34 CALD1
42 pineal region teratoma 10.1 MYOG MYOD1
43 intravenous leiomyomatosis 10.1 CD34 CALD1
44 sarcomatoid squamous cell skin carcinoma 10.1 CD34 CALD1
45 skeletal muscle neoplasm 10.1 MYOG MYOD1
46 retroperitoneal leiomyosarcoma 10.1 CD34 CALD1
47 undifferentiated embryonal sarcoma of the liver 10.1 MYOG MYOD1
48 embryonal sarcoma 10.1 MYOG MYOD1
49 skin sarcoma 10.1 CD34 CALD1
50 gallbladder sarcoma 10.1 MYOG MYOD1

Graphical network of the top 20 diseases related to Adult Fibrosarcoma:



Diseases related to Adult Fibrosarcoma

Symptoms & Phenotypes for Adult Fibrosarcoma

MGI Mouse Phenotypes related to Adult Fibrosarcoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 normal MP:0002873 9.1 CD248 ETV6 MAML3 MYOD1 MYOG NTRK3

Drugs & Therapeutics for Adult Fibrosarcoma

Drugs for Adult Fibrosarcoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 31)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Etoposide Approved Phase 3 33419-42-0 36462
2
Ifosfamide Approved Phase 3 3778-73-2 3690
3
Lenograstim Approved, Investigational Phase 3 135968-09-1
4
Doxorubicin Approved, Investigational Phase 2, Phase 3 23214-92-8 31703
5
Trabectedin Approved, Investigational Phase 2, Phase 3 114899-77-3 108150
6 Etoposide phosphate Phase 3
7
Isophosphamide mustard Phase 3 100427
8 Antibiotics, Antitubercular Phase 2, Phase 3
9
Liposomal doxorubicin Phase 2, Phase 3 31703
10 Alkylating Agents Phase 2, Phase 3
11 Anti-Bacterial Agents Phase 2, Phase 3
12
Temozolomide Approved, Investigational Phase 2 85622-93-1 5394
13
Sunitinib Approved, Investigational Phase 2 557795-19-4, 341031-54-7 5329102
14
Exatecan Investigational Phase 2 171335-80-1
15
Soblidotin Investigational Phase 2 149606-27-9
16
Saracatinib Investigational Phase 2 379231-04-6
17 Angiogenesis Inhibitors Phase 2
18 Immunosuppressive Agents Phase 2
19 Protein Kinase Inhibitors Phase 2
20 topoisomerase I inhibitors Phase 2
21 Imatinib Mesylate Phase 2 220127-57-1 123596
22
Celecoxib Approved, Investigational Phase 1 169590-42-5 2662
23 Analgesics, Non-Narcotic Phase 1
24 Cyclooxygenase 2 Inhibitors Phase 1
25 Analgesics Phase 1
26 Cyclooxygenase Inhibitors Phase 1
27 Antirheumatic Agents Phase 1
28 Anti-Inflammatory Agents Phase 1
29 Anti-Inflammatory Agents, Non-Steroidal Phase 1
30 Cola Early Phase 1
31 Liver Extracts Early Phase 1

Interventional clinical trials:

(show all 27)
# Name Status NCT ID Phase Drugs
1 A Phase III Randomized Study of Preoperative Radiotherapy Plus Surgery Versus Surgery Alone for Patients With Retroperitoneal Sarcoma (RPS) Unknown status NCT01344018 Phase 3
2 A Phase III Randomized Study of Preoperative Radiation Plus Surgery Versus Surgery Alone for Patients With Retroperitoneal Sarcomas (RPS) Completed NCT00091351 Phase 3
3 Randomized Study Comparing Neoadjuvant Chemotherapy Etoposide + Ifosfamide + Adriamycin (EIA) Combined With Regional Hyperthermia (RHT) Versus Neoadjuvant Chemotherapy Alone in the Treatment of High-Risk Soft Tissue Sarcomas in Adults Completed NCT00003052 Phase 3 doxorubicin hydrochloride;etoposide;ifosfamide
4 Randomized Phase III Trial of Two Investigational Schedules of Ifosfamide vs. Standard Dose Doxorubicin in Patients With Advanced or Metastatic Soft Tissue Sarcoma Completed NCT00003212 Phase 3 doxorubicin hydrochloride;ifosfamide
5 RANDOMISED TRIAL OF ADJUVANT CHEMOTHERAPY WITH HIGH-DOSE DOXORUBICIN, IFOSFAMIDE AND LENOGRASTIM IN HIGH GRADE SOFT TISSUE SARCOMA Completed NCT00002641 Phase 3 doxorubicin hydrochloride;ifosfamide;isolated perfusion
6 Randomised Trial Of Single Agent Doxorubicin Versus Doxorubicin Plus Ifosfamide In The First Line Treatment Of Advanced Or Metastatic Soft Tissue Sarcoma Completed NCT00061984 Phase 3 doxorubicin hydrochloride;ifosfamide
7 Randomised Trial of Post-Operative Radiotherapy Given to Adult Patients With Extremity Soft Tissue Sarcoma [VORTEX] Completed NCT00423618 Phase 3
8 METASTASECTOMY AND CHEMOTHERAPY FOR LUNG METASTASES FROM SOFT TISSUE SARCOMA: A RANDOMIZED PHASE III STUDY (AN INTERGROUP STUDY WITH THE SCANDINAVIAN SARCOMA GROUP) Completed NCT00002764 Phase 3 doxorubicin hydrochloride;ifosfamide
9 TRUSTS: A Phase IIB/III Multicenter Study Comparing the Efficacy of TRabectedin Administered as a 3-Hour or 24-Hour Infusion to Doxorubicin in Patients With Advanced or Metastatic Untreated Soft Tissue Sarcoma Terminated NCT01189253 Phase 2, Phase 3 doxorubicin hydrochloride;trabectedin
10 Randomized Phase II Study of Brostallicin (PNU-166196A) Versus Doxorubicin as First Line Chemotherapy in Patients With Advanced or Metastatic Soft Tissue Sarcoma Unknown status NCT00410462 Phase 2 brostallicin;doxorubicin hydrochloride
11 Phase II Evaluation of Temodal (Temozolomide, Schering) in Previously Treated Advanced Sarcomas Unknown status NCT00003718 Phase 2 temozolomide
12 A Multicenter Phase II Study of Continuous Dosing of Sunitinib (Sutent®, SU11248) in Non-GIST Sarcomas Completed NCT00474994 Phase 2 sunitinib malate
13 A Phase II Study Of Perifosine (D-21266) In Patients With Previously Untreated Metastatic Or Locally Advanced Soft Tissue Sarcoma Completed NCT00053794 Phase 2 perifosine
14 Efficacy And Safety Study Of Brostallicin In Patients With Locally Advanced Or Metastatic Soft Tissue Sarcoma Failing One Prior Chemotherapy Treatment Completed NCT00041249 Phase 2 brostallicin
15 Exatecan As Second-Line Treatment In Advanced Adult Soft Tissue Sarcoma: A Phase II - Study Of The EORTC Soft Tissue And Bone Sarcoma Group Completed NCT00041236 Phase 2 exatecan mesylate
16 Phase II Study of Glivec (Imatinib) in Locally Advanced and/or Metastatic Soft Tissue Sarcomas Expressing the t(17;22)(q22;q13) Translocation Resulting in a COL1A1/PDGF-beta Fusion Protein i.e. DermatoFibroSarcoma Protuberans (DFSP) and Giant Cell Fibroblastoma (GCF) Completed NCT00085475 Phase 2 imatinib mesylate
17 A Phase II Study of Intravenous TZT-1027, Administered Weekly Times Two, Every Three Weeks, to Patients With Advanced or Metastatic Soft Tissue Sarcomas (STS) With Prior Exposure to Anthracycline-Based Chemotherapy Completed NCT00064220 Phase 2 soblidotin
18 Dose Finding and Phase II Study of STI 571 in Advanced Soft Tissue Sarcoma Completed NCT00006357 Phase 1, Phase 2 imatinib mesylate
19 Phase II Study on ET-743 in Advanced Soft Tissue Sarcomas of the Adult Completed NCT00003939 Phase 2 trabectedin
20 Multicenter Parallel Phase II Trial of BI 2536 Administered as One Hour IV Infusion Every 3 Weeks in Defined Cohorts of Patients With Various Solid Tumors. A New Drug Screening Program of the EORTC Network of Core Institutions (NOCI) Completed NCT00526149 Phase 2 BI 2536
21 A Phase II Study of Imatinib (NSC-716051) in Patients With Locally Advanced or Metastatic Dermatofibrosarcoma Protuberans Completed NCT00084630 Phase 2 imatinib mesylate
22 A Phase 2 Study of AZD0530 in Recurrent or Metastatic Soft Tissue Sarcoma Completed NCT00659360 Phase 2 saracatinib
23 Phase II Study of Preoperative Intensity-Modulated Radiation Therapy for Soft-Tissue Sarcomas Terminated NCT00740597 Phase 2
24 A Phase I Trial of Postoperative Radiation With Dose-Escalation of A Cox-2 Inhibitor, Celebrex™ (CELECOXIB) in Patients With Soft Tissue Sarcoma of the Extremity Completed NCT00450736 Phase 1 celecoxib
25 Phase I Study To Determine The Safety Of Caelyx (Doxorubin HCI, Pegylated Liposomal) In Combination With Ifosfamide In Previously Untreated Adult Patients With Advanced And/Or Metastatic Soft Tissues Sarcomas Completed NCT00030784 Phase 1 ifosfamide;pegylated liposomal doxorubicin hydrochloride
26 VORTEX-BIOBANK: Prospective Sample Collection for the VORTEX Randomised Radiotherapy Trial in Patients With Extremity Soft Tissue Sarcoma [VORTEX BIOBANK] Unknown status NCT00900211
27 An Evaluation of the Tissue Distribution and the Selective Tumor Trafficking of TNF-Bound Colloidal Gold (CYT-6091) Following Intravenous Administration in Subjects With Primary and Metastatic Cancer Undergoing Surgical Resection Completed NCT00436410 Early Phase 1

Search NIH Clinical Center for Adult Fibrosarcoma

Genetic Tests for Adult Fibrosarcoma

Anatomical Context for Adult Fibrosarcoma

MalaCards organs/tissues related to Adult Fibrosarcoma:

40
Bone, Liver

Publications for Adult Fibrosarcoma

Articles related to Adult Fibrosarcoma:

(show all 26)
# Title Authors PMID Year
1
Dedifferentiated secretory breast carcinoma with fibrosarcomatous features harboring an ETV6-NTRK3 fusion in both components. 61
33342011 2020
2
Cervical Infantile Fibrosarcoma: a rare cause of paediatric parapharyngeal neck mass. 61
33344316 2020
3
Soft tissue tumors characterized by a wide spectrum of kinase fusions share a lipofibromatosis-like neural tumor pattern. 61
32506523 2020
4
[Spindle cell/sclerosing rhabdomyosarcoma: a clinicopathological study of 20 cases]. 61
32268670 2020
5
Fibrosarcoma of anterior abdominal wall: A rare case report. 61
33171433 2020
6
Recurrent fibrosarcoma of maxillary sinus involving the cranial base: A rare case. 61
29970723 2018
7
CT and MRI Findings of Soft Tissue Adult Fibrosarcoma in Extremities. 61
29693010 2018
8
Pediatric Fibroblastic and Myofibroblastic Tumors: A Pictorial Review. 61
27399243 2016
9
Adult fibrosarcoma: surgical management in developing countries. 61
25528208 2015
10
Sentinel node biopsy in pediatric patients: the experience in a single institution. 61
25478665 2014
11
Fibrosarcoma: a review and update. 61
24266941 2014
12
Spindle cell rhabdomyosarcoma of the retroperitoneum: an unusual case developed in a pregnant woman but obscured by pregnancy. 61
25197361 2014
13
Malignant transformation of orbital solitary fibrous tumor. 61
23525957 2013
14
Adult fibrosarcoma of the wrist: a case report. 61
22689150 2012
15
A rare case of juvenile fibrosarcoma of eyelid. 61
18094736 2007
16
Infantile fibrosarcoma of thigh--a case report. 61
15801689 2005
17
Sclerosing epitheloid fibrosarcoma. A report of two cases. 61
15688980 2004
18
Gains of 12q are the most frequent genomic imbalances in adult fibrosarcoma and are correlated with a poor outcome. 61
11921284 2002
19
Expression of COL1A1-PDGFB fusion transcripts in superficial adult fibrosarcoma suggests a close relationship to dermatofibrosarcoma protuberans. 61
11329146 2001
20
The detection of Tel-TrkC chimeric transcripts is more specific than TrkC immunoreactivity for the diagnosis of congenital fibrosarcoma. 61
11169520 2001
21
Recurrent chromosome changes in two adult fibrosarcomas. 61
9491323 1998
22
A comparative study of apoptosis and cell proliferation in infantile and adult fibrosarcomas. 61
8853038 1996
23
Multiple chromosome rearrangements in a fibrosarcoma. 61
8625267 1996
24
Congenital-infantile fibrosarcoma: study of two cases and review of the literature. 61
7839472 1994
25
Mixed hepatoblastoma in the adult: case report and review of the literature. 61
6255014 1980
26
Infantile and adult fibrosarcomas of the soft tissues. 61
452901 1979

Variations for Adult Fibrosarcoma

Expression for Adult Fibrosarcoma

Search GEO for disease gene expression data for Adult Fibrosarcoma.

Pathways for Adult Fibrosarcoma

Pathways related to Adult Fibrosarcoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.78 MYOG MYOD1 CD34

GO Terms for Adult Fibrosarcoma

Cellular components related to Adult Fibrosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 myofibril GO:0030016 8.62 MYOD1 CALD1

Biological processes related to Adult Fibrosarcoma according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 regulation of transcription, DNA-templated GO:0006355 9.91 SSX1 MYOG MYOD1 ETV6 CREB3L2
2 positive regulation of transcription by RNA polymerase II GO:0045944 9.77 MYOG MYOD1 MAML3 ETV6 CREB3L2
3 skeletal muscle tissue development GO:0007519 9.54 MYOG MYOD1
4 skeletal muscle cell differentiation GO:0035914 9.52 MYOG MYOD1
5 cellular response to estradiol stimulus GO:0071392 9.49 MYOG MYOD1
6 positive regulation of muscle cell differentiation GO:0051149 9.48 MYOG MYOD1
7 skeletal muscle fiber development GO:0048741 9.46 MYOG MYOD1
8 skeletal muscle tissue regeneration GO:0043403 9.43 MYOG MYOD1
9 positive regulation of myoblast differentiation GO:0045663 9.4 MYOG MYOD1
10 myoblast differentiation GO:0045445 9.32 MYOG MYOD1
11 hematopoietic stem cell proliferation GO:0071425 9.26 ETV6 CD34
12 myotube differentiation GO:0014902 9.16 MYOG MYOD1
13 positive regulation of skeletal muscle fiber development GO:0048743 8.96 MYOG MYOD1
14 muscle cell fate commitment GO:0042693 8.62 MYOG MYOD1

Molecular functions related to Adult Fibrosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 DNA-binding transcription factor activity GO:0003700 9.26 MYOG MYOD1 ETV6 CREB3L2
2 E-box binding GO:0070888 9.16 MYOG MYOD1
3 DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001228 8.92 MYOG MYOD1 ETV6 CREB3L2

Sources for Adult Fibrosarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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