MCID: ADL019
MIFTS: 36

Adult Fibrosarcoma

Categories: Bone diseases, Cancer diseases, Rare diseases

Aliases & Classifications for Adult Fibrosarcoma

MalaCards integrated aliases for Adult Fibrosarcoma:

Name: Adult Fibrosarcoma 12 15 74

Classifications:



External Ids:

Disease Ontology 12 DOID:3516
NCIt 51 C7809
UMLS 74 C0278595

Summaries for Adult Fibrosarcoma

MalaCards based summary : Adult Fibrosarcoma is related to dermatofibrosarcoma protuberans and mesenchymoma. An important gene associated with Adult Fibrosarcoma is NTRK3 (Neurotrophic Receptor Tyrosine Kinase 3), and among its related pathways/superpathways are Bisphosphonate Pathway, Pharmacodynamics and Osteoblast Signaling. The drugs Doxorubicin and Ifosfamide have been mentioned in the context of this disorder. Affiliated tissues include lung and liver, and related phenotypes are growth/size/body region and cardiovascular system

Related Diseases for Adult Fibrosarcoma

Diseases in the Fibrosarcoma family:

Adult Fibrosarcoma Congenital Fibrosarcoma

Diseases related to Adult Fibrosarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 73)
# Related Disease Score Top Affiliating Genes
1 dermatofibrosarcoma protuberans 29.7 CD34 COL1A1 PDGFB
2 mesenchymoma 10.4 MB MYOD1
3 cellular congenital mesoblastic nephroma 10.3 ETV6 NTRK3
4 ring chromosome 4 10.3 COL1A1 PDGFB
5 pediatric fibrosarcoma 10.3 ETV6 NTRK3
6 malignant triton tumor 10.3 MB MYOD1
7 botryoid rhabdomyosarcoma 10.3 MB MYOD1
8 bednar tumor 10.3 COL1A1 PDGFB
9 congenital fibrosarcoma 10.3 ETV6 NTRK3
10 spindle cell rhabdomyosarcoma 10.3 MB MYOD1
11 breast secretory carcinoma 10.3 ETV6 NTRK3
12 myofibroma 10.3 ETV6 MB
13 dermis tumor 10.3 COL1A1 PDGFB
14 pleomorphic rhabdomyosarcoma 10.3 MB MYOD1
15 kidney sarcoma 10.2 MB WT1
16 gas gangrene 10.2 MB MYOD1
17 kidney rhabdoid cancer 10.2 MB WT1
18 meninges sarcoma 10.2 CD34 MB
19 undifferentiated embryonal sarcoma of the liver 10.2 MYOD1 MYOG
20 embryonal sarcoma 10.2 MYOD1 MYOG
21 sclerosing liposarcoma 10.2 CD34 MB
22 congenital mesoblastic nephroma 10.2 ETV6 NTRK3 WT1
23 hobnail hemangioma 10.2 CD34 WT1
24 osteogenesis imperfecta, type v 10.1 COL1A1 FDPS
25 inflammatory leiomyosarcoma 10.1 MYOD1 MYOG
26 melanomatosis 10.1 HRAS WT1
27 orbit rhabdomyosarcoma 10.1 MB MYOG
28 fibrosarcoma 10.1
29 conventional leiomyosarcoma 10.1 MYOD1 MYOG
30 peritoneal benign neoplasm 10.1 CD34 WT1
31 bone ewing's sarcoma 10.1 PDGFB WT1
32 angiomyoma 10.1 CD34 MB
33 rhabdoid cancer 10.1 MB MYOD1 WT1
34 diffuse peritoneal leiomyomatosis 10.1 CD34 WT1
35 adult mesoblastic nephroma 10.1 CD34 ETV6 NTRK3
36 venous hemangioma 10.1 CD34 WT1
37 kidney clear cell sarcoma 10.1 ETV6 MB WT1
38 sarcomatoid squamous cell skin carcinoma 10.1 CD34 MB
39 differentiated thyroid carcinoma 10.1 ETV6 HRAS NTRK3
40 cardiovascular organ benign neoplasm 10.1 CD34 MB
41 benign perivascular tumor 10.0 CD34 MB
42 skin sarcoma 10.0 CD34 COL1A1 PDGFB
43 mixed liposarcoma 10.0 CD34 MB PDGFB
44 mixed cell type cancer 10.0 HRAS MB
45 core binding factor acute myeloid leukemia 10.0 HRAS WT1
46 rhabdomyosarcoma 10.0 MB MYOD1 MYOG
47 breast rhabdomyosarcoma 10.0 MB MYOD1 MYOG
48 medullomyoblastoma 10.0 MB MYOD1 MYOG
49 skeletal muscle cancer 10.0 MB MYOD1 MYOG
50 acute leukemia 10.0 CD34 ETV6 WT1

Graphical network of the top 20 diseases related to Adult Fibrosarcoma:



Diseases related to Adult Fibrosarcoma

Symptoms & Phenotypes for Adult Fibrosarcoma

MGI Mouse Phenotypes related to Adult Fibrosarcoma:

47 (show all 11)
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 10.11 COL1A1 ETV6 HRAS MB MYOD1 MYOG
2 cardiovascular system MP:0005385 10.1 COL1A1 ETV6 HRAS MB MYOD1 NTRK3
3 homeostasis/metabolism MP:0005376 10.09 CD34 COL1A1 ETV6 HRAS MB MYOD1
4 mortality/aging MP:0010768 10.02 COL1A1 ETV6 HRAS MB MYOD1 MYOG
5 embryo MP:0005380 9.95 COL1A1 ETV6 MB MYOG PDGFB WT1
6 integument MP:0010771 9.88 CD34 COL1A1 ETV6 HRAS MYOG PDGFB
7 muscle MP:0005369 9.8 COL1A1 MB MYOD1 MYOG PDGFB WT1
8 no phenotypic analysis MP:0003012 9.76 COL1A1 ETV6 HRAS MYOD1 MYOG NTRK3
9 neoplasm MP:0002006 9.73 CD34 COL1A1 ETV6 HRAS MYOD1 WT1
10 normal MP:0002873 9.5 COL1A1 ETV6 HRAS MYOD1 MYOG NTRK3
11 respiratory system MP:0005388 9.23 COL1A1 HRAS MB MYOD1 MYOG NTRK3

Drugs & Therapeutics for Adult Fibrosarcoma

Drugs for Adult Fibrosarcoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 49)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Doxorubicin Approved, Investigational Phase 3,Phase 2,Phase 1 23214-92-8 31703
2
Ifosfamide Approved Phase 3,Phase 2,Phase 1 3778-73-2 3690
3
Mechlorethamine Approved, Investigational Phase 3,Phase 2,Phase 1 51-75-2 4033
4
Lenograstim Approved, Investigational Phase 3 135968-09-1
5
Etoposide Approved Phase 3 33419-42-0 36462
6
Trabectedin Approved, Investigational Phase 2, Phase 3 114899-77-3 108150
7
Cyclophosphamide Approved, Investigational Phase 2, Phase 3 6055-19-2, 50-18-0 2907
8
Doxil Approved June 1999 Phase 3,Phase 2,Phase 1 31703
9 Anti-Bacterial Agents Phase 3,Phase 2,Phase 1
10 Antineoplastic Agents, Alkylating Phase 3,Phase 2,Phase 1
11 Topoisomerase Inhibitors Phase 3,Phase 2,Phase 1
12 Alkylating Agents Phase 3,Phase 2,Phase 1
13 Antibiotics, Antitubercular Phase 3,Phase 2,Phase 1
14
Isophosphamide mustard Phase 3,Phase 2,Phase 1 0
15 Antineoplastic Agents, Phytogenic Phase 3,Phase 2
16 Etoposide phosphate Phase 3
17
Temozolomide Approved, Investigational Phase 2 85622-93-1 5394
18
Romidepsin Approved, Investigational Phase 2 128517-07-7 5352062
19
Sunitinib Approved, Investigational Phase 2 557795-19-4, 341031-54-7 5329102
20
Gemcitabine Approved Phase 2 95058-81-4 60750
21
Saracatinib Investigational Phase 2 379231-04-6
22
Camptothecin Experimental Phase 2 7689-03-4
23 Exatecan Investigational Phase 2 171335-80-1
24 Soblidotin Investigational Phase 2 149606-27-9
25 Protein Kinase Inhibitors Phase 2,Phase 1
26 Imatinib Mesylate Phase 2,Phase 1 220127-57-1 123596
27 topoisomerase I inhibitors Phase 2
28 Angiogenesis Modulating Agents Phase 2
29 Angiogenesis Inhibitors Phase 2
30 Immunosuppressive Agents Phase 2
31 Antimetabolites, Antineoplastic Phase 2
32 Immunologic Factors Phase 2
33 Antimetabolites Phase 2
34 Anti-Infective Agents Phase 2
35 Antiviral Agents Phase 2
36
Celecoxib Approved, Investigational Phase 1 169590-42-5 2662
37 Antibodies Phase 1
38 Immunoglobulins Phase 1
39 Antibodies, Monoclonal Phase 1
40 Analgesics Phase 1
41 Antirheumatic Agents Phase 1
42 Analgesics, Non-Narcotic Phase 1
43 Peripheral Nervous System Agents Phase 1
44 Anti-Inflammatory Agents Phase 1
45 Cyclooxygenase Inhibitors Phase 1
46 Anti-Inflammatory Agents, Non-Steroidal Phase 1
47 Cyclooxygenase 2 Inhibitors Phase 1
48 Cola Early Phase 1
49 Liver Extracts Early Phase 1

Interventional clinical trials:

(show all 34)
# Name Status NCT ID Phase Drugs
1 Surgery With or Without Radiation Therapy in Untreated Nonmetastatic Retroperitoneal Sarcoma Unknown status NCT01344018 Phase 3
2 Observation, Radiation Therapy, Combination Chemotherapy, and/or Surgery in Treating Young Patients With Soft Tissue Sarcoma Completed NCT00346164 Phase 3 doxorubicin hydrochloride;ifosfamide
3 Surgery With or Without Combination Chemotherapy in Treating Patients With Lung Metastases From Soft Tissue Sarcoma Completed NCT00002764 Phase 3 doxorubicin hydrochloride;ifosfamide
4 Ifosfamide or Doxorubicin in Treating Patients With Advanced or Metastatic Soft Tissue Sarcoma Completed NCT00003212 Phase 3 doxorubicin hydrochloride;ifosfamide
5 Combination Chemotherapy With or Without Hyperthermia Therapy in Treating Patients With Soft Tissue Sarcoma Completed NCT00003052 Phase 3 doxorubicin hydrochloride;etoposide;ifosfamide
6 Surgery With or Without Chemotherapy in Treating Patients With Soft Tissue Sarcoma Completed NCT00002641 Phase 3 doxorubicin hydrochloride;ifosfamide;isolated perfusion
7 Doxorubicin With or Without Ifosfamide and Pegfilgrastim in Treating Patients With Locally Advanced or Metastatic Soft Tissue Sarcoma Completed NCT00061984 Phase 3 doxorubicin hydrochloride;ifosfamide
8 Surgery With or Without Radiation Therapy in Treating Patients With Primary Soft Tissue Sarcoma of the Retroperitoneum or Pelvis Completed NCT00091351 Phase 3
9 Randomised Trial of Volume of Post-operative Radiotherapy Given to Adult Patients With eXtremity Soft Tissue Sarcoma Completed NCT00423618 Phase 3
10 Radiation Therapy With or Without Combination Chemotherapy or Pazopanib Hydrochloride Before Surgery in Treating Patients With Newly Diagnosed Non-rhabdomyosarcoma Soft Tissue Sarcomas That Can Be Removed by Surgery Active, not recruiting NCT02180867 Phase 2, Phase 3 Doxorubicin Hydrochloride;Ifosfamide;Pazopanib Hydrochloride
11 Doxorubicin Hydrochloride or Trabectedin in Treating Patients With Previously Untreated Advanced or Metastatic Soft Tissue Sarcoma Terminated NCT01189253 Phase 2, Phase 3 doxorubicin hydrochloride;trabectedin
12 Temozolomide in Treating Patients With Advanced Soft Tissue Sarcoma Unknown status NCT00003718 Phase 2 temozolomide
13 Brostallicin or Doxorubicin as First-Line Therapy in Treating Patients With Relapsed, Refractory, or Metastatic Soft Tissue Sarcoma Unknown status NCT00410462 Phase 2 brostallicin;doxorubicin hydrochloride
14 Imatinib Mesylate in Treating Patients With Locally Recurrent or Metastatic Dermatofibrosarcoma Protuberans Completed NCT00084630 Phase 2 imatinib mesylate
15 Imatinib Mesylate in Treating Patients With Locally Advanced or Metastatic Dermatofibrosarcoma Protuberans or Giant Cell Fibroblastoma Completed NCT00085475 Phase 2 imatinib mesylate
16 AZD0530 in Treating Patients With Recurrent Locally Advanced or Metastatic Soft Tissue Sarcoma Completed NCT00659360 Phase 2 saracatinib
17 Vismodegib and Gamma-Secretase/Notch Signalling Pathway Inhibitor RO4929097 in Treating Patients With Advanced or Metastatic Sarcoma Completed NCT01154452 Phase 1, Phase 2 Gamma-Secretase Inhibitor RO4929097;Vismodegib
18 Depsipeptide (Romidepsin) in Treating Patients With Metastatic or Unresectable Soft Tissue Sarcoma Completed NCT00112463 Phase 2 romidepsin
19 Ecteinascidin 743 in Treating Patients With Advanced Soft Tissue Sarcoma Completed NCT00003939 Phase 2 trabectedin
20 STI571 in Treating Patients With Recurrent or Refractory Soft Tissue Sarcoma Completed NCT00006357 Phase 1, Phase 2 imatinib mesylate
21 Brostallicin in Treating Patients With Locally Advanced or Metastatic Soft Tissue Sarcoma Completed NCT00041249 Phase 2 brostallicin
22 Exatecan Mesylate in Treating Patients With Advanced Soft Tissue Sarcoma Completed NCT00041236 Phase 2 exatecan mesylate
23 Perifosine in Treating Patients With Metastatic or Locally Advanced Soft Tissue Sarcoma Completed NCT00053794 Phase 2 perifosine
24 BI 2536 in Treating Patients With Recurrent or Metastatic Solid Tumors Completed NCT00526149 Phase 2 BI 2536
25 Sunitinib in Treating Patients With Metastatic, Locally Advanced, or Locally Recurrent Sarcomas Completed NCT00474994 Phase 2 sunitinib malate
26 Soblidotin in Treating Patients With Advanced or Metastatic Soft Tissue Sarcoma Completed NCT00064220 Phase 2 soblidotin
27 Gemcitabine Hydrochloride With or Without Pazopanib Hydrochloride in Treating Patients With Refractory Soft Tissue Sarcoma Recruiting NCT01532687 Phase 2 Gemcitabine Hydrochloride;Pazopanib Hydrochloride
28 S9624 Ifosfamide in Treating Patients With Meningeal Tumors Terminated NCT00003292 Phase 2 ifosfamide
29 Intensity-Modulated Radiation Therapy in Treating Patients Undergoing Surgery for Stage IB, Stage II, or Stage III Soft Tissue Sarcoma Terminated NCT00740597 Phase 2
30 Cixutumumab and Doxorubicin Hydrochloride in Treating Patients With Unresectable, Locally Advanced, or Metastatic Soft Tissue Sarcoma Completed NCT00720174 Phase 1 Doxorubicin Hydrochloride
31 Liposomal Doxorubicin Plus Ifosfamide in Treating Patients With Advanced or Metastatic Soft Tissue Sarcoma Completed NCT00030784 Phase 1 ifosfamide;pegylated liposomal doxorubicin hydrochloride
32 Celecoxib and Radiation Therapy in Treating Patients With Stage II or Stage III Soft Tissue Sarcoma of the Arm, Hand, Leg, or Foot That Has Been Removed by Surgery Completed NCT00450736 Phase 1 celecoxib
33 Tissue Sample Collection From Patients With Soft Tissue Sarcoma of the Arms, Hands, Legs, or Feet Treated on Clinial Trial CRUK-VORTEX Unknown status NCT00900211
34 Tumor Necrosis Factor in Patients Undergoing Surgery for Primary Cancer or Metastatic Cancer Completed NCT00436410 Early Phase 1

Search NIH Clinical Center for Adult Fibrosarcoma

Genetic Tests for Adult Fibrosarcoma

Anatomical Context for Adult Fibrosarcoma

MalaCards organs/tissues related to Adult Fibrosarcoma:

42
Lung, Liver

Publications for Adult Fibrosarcoma

Articles related to Adult Fibrosarcoma:

# Title Authors Year
1
CT and MRI Findings of Soft Tissue Adult Fibrosarcoma in Extremities. ( 29693010 )
2018
2
Adult fibrosarcoma: surgical management in developing countries. ( 25528208 )
2015
3
Adult fibrosarcoma of the wrist: a case report. ( 22689150 )
2012
4
Gains of 12q are the most frequent genomic imbalances in adult fibrosarcoma and are correlated with a poor outcome. ( 11921284 )
2002
5
Expression of COL1A1-PDGFB fusion transcripts in superficial adult fibrosarcoma suggests a close relationship to dermatofibrosarcoma protuberans. ( 11329146 )
2001

Variations for Adult Fibrosarcoma

Expression for Adult Fibrosarcoma

Search GEO for disease gene expression data for Adult Fibrosarcoma.

Pathways for Adult Fibrosarcoma

Pathways related to Adult Fibrosarcoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
10.42 FDPS HRAS
2 9.77 COL1A1 PDGFB

GO Terms for Adult Fibrosarcoma

Biological processes related to Adult Fibrosarcoma according to GeneCards Suite gene sharing:

(show all 23)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription, DNA-templated GO:0045893 9.8 COL1A1 MYOD1 MYOG PDGFB WT1
2 positive regulation of MAPK cascade GO:0043410 9.7 HRAS NTRK3 PDGFB
3 cellular response to tumor necrosis factor GO:0071356 9.69 COL1A1 MYOD1 MYOG
4 cellular response to estradiol stimulus GO:0071392 9.61 MYOD1 MYOG
5 activation of protein kinase B activity GO:0032148 9.61 NTRK3 PDGFB
6 positive regulation of pri-miRNA transcription by RNA polymerase II GO:1902895 9.59 PDGFB WT1
7 positive regulation of muscle cell differentiation GO:0051149 9.58 MYOD1 MYOG
8 skeletal muscle fiber development GO:0048741 9.58 MYOD1 MYOG
9 positive regulation of myoblast differentiation GO:0045663 9.57 MYOD1 MYOG
10 myoblast differentiation GO:0045445 9.56 MYOD1 MYOG
11 heart development GO:0007507 9.56 MB NTRK3 PDGFB WT1
12 positive regulation of actin cytoskeleton reorganization GO:2000251 9.55 HRAS NTRK3
13 positive regulation of myoblast fusion GO:1901741 9.54 MYOD1 MYOG
14 cellular response to retinoic acid GO:0071300 9.5 COL1A1 MYOG NTRK3
15 hematopoietic stem cell proliferation GO:0071425 9.49 CD34 ETV6
16 myotube differentiation GO:0014902 9.48 MYOD1 MYOG
17 positive regulation of phospholipase C activity GO:0010863 9.46 HRAS NTRK3
18 positive regulation of skeletal muscle fiber development GO:0048743 9.43 MYOD1 MYOG
19 paracrine signaling GO:0038001 9.37 CD34 PDGFB
20 positive regulation of cell migration GO:0030335 9.26 COL1A1 HRAS NTRK3 PDGFB
21 muscle cell fate commitment GO:0042693 9.16 MYOD1 MYOG
22 positive regulation of gene expression GO:0010628 9.02 CD34 HRAS NTRK3 PDGFB WT1
23 positive regulation of transcription by RNA polymerase II GO:0045944 10 ETV6 HRAS MYOD1 MYOG WT1

Molecular functions related to Adult Fibrosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001228 9.13 MYOD1 MYOG WT1
2 platelet-derived growth factor binding GO:0048407 8.62 COL1A1 PDGFB

Sources for Adult Fibrosarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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