MCID: ADL044
MIFTS: 24

Adult Infiltrating Astrocytic Neoplasm

Categories: Bone diseases, Cancer diseases, Neuronal diseases

Aliases & Classifications for Adult Infiltrating Astrocytic Neoplasm

MalaCards integrated aliases for Adult Infiltrating Astrocytic Neoplasm:

Name: Adult Infiltrating Astrocytic Neoplasm 12 15
Adult Infiltrating Astrocytoma 12 71
Adult Infiltrating Astrocytic Tumor 12

Classifications:



External Ids:

Disease Ontology 12 DOID:7656
NCIt 49 C8289
UMLS 71 C0281329

Summaries for Adult Infiltrating Astrocytic Neoplasm

MalaCards based summary : Adult Infiltrating Astrocytic Neoplasm, also known as adult infiltrating astrocytoma, is related to fibrillary astrocytoma and diffuse intrinsic pontine glioma. An important gene associated with Adult Infiltrating Astrocytic Neoplasm is H3C10 (H3 Clustered Histone 10), and among its related pathways/superpathways are Signaling by GPCR and Innate Immune System. The drugs Carmustine and Mercaptopurine have been mentioned in the context of this disorder. Affiliated tissues include brain and bone.

Related Diseases for Adult Infiltrating Astrocytic Neoplasm

Diseases related to Adult Infiltrating Astrocytic Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 fibrillary astrocytoma 9.6 H3C2 H3C10
2 diffuse intrinsic pontine glioma 9.5 H3C2 H3C1
3 childhood pilocytic astrocytoma 9.4 H3C12 H3C11 H3C10
4 brain stem cancer 8.1 H3C7 H3C2 H3C12 H3C11 H3C10 H3C1
5 pilomyxoid astrocytoma 8.1 H3C7 H3C2 H3C12 H3C11 H3C10 H3C1
6 brain stem glioma 8.1 H3C7 H3C2 H3C12 H3C11 H3C10 H3C1
7 giant cell glioblastoma 8.0 H3C7 H3C2 H3C12 H3C11 H3C10 H3C1
8 glioblastoma multiforme 8.0 H3C7 H3C2 H3C12 H3C11 H3C10 H3C1

Graphical network of the top 20 diseases related to Adult Infiltrating Astrocytic Neoplasm:



Diseases related to Adult Infiltrating Astrocytic Neoplasm

Symptoms & Phenotypes for Adult Infiltrating Astrocytic Neoplasm

Drugs & Therapeutics for Adult Infiltrating Astrocytic Neoplasm

Drugs for Adult Infiltrating Astrocytic Neoplasm (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 9)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Carmustine Approved, Investigational Phase 2 154-93-8 2578
2
Mercaptopurine Approved Phase 2 50-44-2 667490
3
Streptozocin Approved, Investigational Phase 2 18883-66-4 29327
4 Immunosuppressive Agents Phase 2
5 Anti-Bacterial Agents Phase 2
6 Alkylating Agents Phase 2
7 Antibiotics, Antitubercular Phase 2
8 Immunologic Factors Phase 2
9 Antimetabolites Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Phase II Study of Carmustine, Streptozocin, and Mercaptopurine for Refractory or Recurrent Brain Neoplasms Completed NCT00004688 Phase 2 carmustine;mercaptopurine;streptozocin
2 Phase I Pilot Study of Stereotaxic Radiosurgery in Patients With Intracranial Neoplasms Completed NCT00019578 Phase 1

Search NIH Clinical Center for Adult Infiltrating Astrocytic Neoplasm

Genetic Tests for Adult Infiltrating Astrocytic Neoplasm

Anatomical Context for Adult Infiltrating Astrocytic Neoplasm

MalaCards organs/tissues related to Adult Infiltrating Astrocytic Neoplasm:

40
Brain, Bone

Publications for Adult Infiltrating Astrocytic Neoplasm

Variations for Adult Infiltrating Astrocytic Neoplasm

Expression for Adult Infiltrating Astrocytic Neoplasm

Search GEO for disease gene expression data for Adult Infiltrating Astrocytic Neoplasm.

Pathways for Adult Infiltrating Astrocytic Neoplasm

Pathways related to Adult Infiltrating Astrocytic Neoplasm according to GeneCards Suite gene sharing:

(show all 27)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.81 H3C7 H3C2 H3C12 H3C11 H3C10 H3C1
2
Show member pathways
13.7 H3C7 H3C2 H3C12 H3C11 H3C10 H3C1
3
Show member pathways
13.56 H3C7 H3C2 H3C12 H3C11 H3C10 H3C1
4
Show member pathways
13.54 H3C7 H3C2 H3C12 H3C11 H3C10 H3C1
5
Show member pathways
13.53 H3C7 H3C2 H3C12 H3C11 H3C10 H3C1
6
Show member pathways
13.52 H3C7 H3C2 H3C12 H3C11 H3C10 H3C1
7
Show member pathways
13.51 H3C7 H3C2 H3C12 H3C11 H3C10 H3C1
8
Show member pathways
13.31 H3C7 H3C2 H3C12 H3C11 H3C10 H3C1
9
Show member pathways
13.31 H3C7 H3C2 H3C12 H3C11 H3C10 H3C1
10
Show member pathways
13.26 H3C7 H3C2 H3C12 H3C11 H3C10 H3C1
11
Show member pathways
13.2 H3C7 H3C2 H3C12 H3C11 H3C10 H3C1
12
Show member pathways
13.14 H3C7 H3C2 H3C12 H3C11 H3C10 H3C1
13
Show member pathways
13.1 H3C7 H3C2 H3C12 H3C11 H3C10 H3C1
14
Show member pathways
12.96 H3C7 H3C2 H3C12 H3C11 H3C10 H3C1
15
Show member pathways
12.86 H3C7 H3C2 H3C12 H3C11 H3C10 H3C1
16
Show member pathways
12.85 H3C7 H3C2 H3C12 H3C11 H3C10 H3C1
17
Show member pathways
12.82 H3C7 H3C2 H3C12 H3C11 H3C10 H3C1
18
Show member pathways
12.72 H3C7 H3C2 H3C12 H3C11 H3C10 H3C1
19
Show member pathways
12.56 H3C7 H3C2 H3C12 H3C11 H3C10 H3C1
20
Show member pathways
12.37 H3C7 H3C2 H3C12 H3C11 H3C10 H3C1
21 12.25 H3C7 H3C2 H3C12 H3C11 H3C10 H3C1
22
Show member pathways
12.15 H3C7 H3C2 H3C12 H3C11 H3C10 H3C1
23 12.07 H3C7 H3C2 H3C12 H3C11 H3C10 H3C1
24 11.93 H3C7 H3C2 H3C12 H3C11 H3C10 H3C1
25
Show member pathways
11.73 H3C7 H3C2 H3C12 H3C11 H3C10 H3C1
26
Show member pathways
11.59 H3C7 H3C2 H3C12 H3C11 H3C10 H3C1
27 10.55 H3C7 H3C2 H3C12 H3C11 H3C10 H3C1

GO Terms for Adult Infiltrating Astrocytic Neoplasm

Cellular components related to Adult Infiltrating Astrocytic Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nucleus GO:0005634 9.93 H3C7 H3C2 H3C12 H3C11 H3C10 H3C1
2 nucleoplasm GO:0005654 9.91 H3C7 H3C2 H3C12 H3C11 H3C10 H3C1
3 extracellular region GO:0005576 9.88 H3C7 H3C2 H3C12 H3C11 H3C10 H3C1
4 extracellular exosome GO:0070062 9.85 H3C7 H3C2 H3C12 H3C11 H3C10 H3C1
5 protein-containing complex GO:0032991 9.8 H3C7 H3C2 H3C12 H3C11 H3C10 H3C1
6 chromosome GO:0005694 9.73 H3C7 H3C2 H3C12 H3C11 H3C10 H3C1
7 nucleosome GO:0000786 9.63 H3C7 H3C2 H3C12 H3C11 H3C10 H3C1
8 nuclear chromosome GO:0000228 9.43 H3C7 H3C2 H3C12 H3C11 H3C10 H3C1
9 nuclear nucleosome GO:0000788 9.1 H3C7 H3C2 H3C12 H3C11 H3C10 H3C1

Biological processes related to Adult Infiltrating Astrocytic Neoplasm according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 chromatin organization GO:0006325 10 H3C7 H3C2 H3C12 H3C11 H3C10 H3C1
2 cellular protein metabolic process GO:0044267 9.99 H3C7 H3C2 H3C12 H3C11 H3C10 H3C1
3 blood coagulation GO:0007596 9.97 H3C7 H3C2 H3C12 H3C11 H3C10 H3C1
4 nucleosome assembly GO:0006334 9.95 H3C7 H3C2 H3C12 H3C11 H3C10 H3C1
5 regulation of gene silencing by miRNA GO:0060964 9.93 H3C7 H3C2 H3C12 H3C11 H3C10 H3C1
6 regulation of megakaryocyte differentiation GO:0045652 9.91 H3C7 H3C2 H3C12 H3C11 H3C10 H3C1
7 protein heterotetramerization GO:0051290 9.88 H3C7 H3C2 H3C12 H3C11 H3C10 H3C1
8 negative regulation of gene expression, epigenetic GO:0045814 9.85 H3C7 H3C2 H3C12 H3C11 H3C10 H3C1
9 regulation of gene silencing GO:0060968 9.8 H3C7 H3C2 H3C12 H3C11 H3C10 H3C1
10 interleukin-7-mediated signaling pathway GO:0038111 9.73 H3C7 H3C2 H3C12 H3C11 H3C10 H3C1
11 telomere organization GO:0032200 9.63 H3C7 H3C2 H3C12 H3C11 H3C10 H3C1
12 DNA replication-dependent nucleosome assembly GO:0006335 9.43 H3C7 H3C2 H3C12 H3C11 H3C10 H3C1
13 chromatin silencing at rDNA GO:0000183 9.1 H3C7 H3C2 H3C12 H3C11 H3C10 H3C1

Molecular functions related to Adult Infiltrating Astrocytic Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 DNA binding GO:0003677 9.63 H3C7 H3C2 H3C12 H3C11 H3C10 H3C1
2 protein heterodimerization activity GO:0046982 9.43 H3C7 H3C2 H3C12 H3C11 H3C10 H3C1
3 cadherin binding GO:0045296 9.1 H3C7 H3C2 H3C12 H3C11 H3C10 H3C1

Sources for Adult Infiltrating Astrocytic Neoplasm

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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