MCID: ADL015
MIFTS: 32

Adult Liposarcoma

Categories: Cancer diseases, Rare diseases

Aliases & Classifications for Adult Liposarcoma

MalaCards integrated aliases for Adult Liposarcoma:

Name: Adult Liposarcoma 12 15 71

Classifications:



External Ids:

Disease Ontology 12 DOID:5693
NCIt 50 C7811
UMLS 71 C0278608

Summaries for Adult Liposarcoma

MalaCards based summary : Adult Liposarcoma is related to breast liposarcoma and ring chromosome 7. An important gene associated with Adult Liposarcoma is MYCBP (MYC Binding Protein), and among its related pathways/superpathways are ERK Signaling and PI3K-Akt signaling pathway. The drugs Doxorubicin and Lenograstim have been mentioned in the context of this disorder. Affiliated tissues include bone and t cells, and related phenotypes are Reduced mammosphere formation and cardiovascular system

Related Diseases for Adult Liposarcoma

Diseases in the Liposarcoma family:

Adult Liposarcoma Inflammatory Liposarcoma

Diseases related to Adult Liposarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 44)
# Related Disease Score Top Affiliating Genes
1 breast liposarcoma 9.9 NOTCH1 CDK4
2 ring chromosome 7 9.8 MDM2 CDK4
3 ring chromosome 9.8 MDM2 CDK4
4 mediastinum liposarcoma 9.8 MDM2 CDK4
5 gastric liposarcoma 9.8 MDM2 CDK4
6 infiltrating lipoma 9.8 MDM2 CDK4
7 spindle cell liposarcoma 9.8 MDM2 CDK4
8 pediatric liposarcoma 9.8 MDM2 CDK4
9 ossifying fibroma 9.8 NOTCH1 MDM2
10 undifferentiated embryonal sarcoma of the liver 9.8 MDM2 CDK4
11 diffuse lipomatosis 9.8 MDM2 CDK4
12 lipoblastoma 9.8 MDM2 CDK4
13 malignant inflammatory fibrous histiocytoma 9.8 MDM2 CDK4
14 liposarcoma of bone 9.8 MDM2 CDK4
15 pancreas sarcoma 9.8 MDM2 CDK4
16 paratesticular lipoma 9.8 MDM2 CDK4
17 lipoma of spermatic cord 9.8 MDM2 CDK4
18 mixed liposarcoma 9.8 MDM2 CDK4
19 hereditary melanoma 9.8 MDM2 CDK4
20 infiltrating angiolipoma 9.8 MDM2 CDK4
21 peripheral osteosarcoma 9.8 MDM2 CDK4
22 juxtacortical osteosarcoma 9.8 MDM2 CDK4
23 pleomorphic lipoma 9.8 MDM2 CDK4
24 extraosseous osteosarcoma 9.8 MDM2 CDK4
25 retroperitoneal sarcoma 9.8 MDM2 CDK4
26 parameningeal embryonal rhabdomyosarcoma 9.8 MDM2 CDK4
27 spindle cell lipoma 9.8 MDM2 CDK4
28 myositis ossificans 9.7 MDM2 CDK4
29 cellular myxoid liposarcoma 9.7 MDM2 CDK4
30 ischemic fasciitis 9.7 MDM2 CDK4
31 retroperitoneum carcinoma 9.7 MDM2 CDK4
32 familial retinoblastoma 9.7 MDM2 CDK4
33 conventional central osteosarcoma 9.7 MDM2 CDK4
34 pleomorphic liposarcoma 9.7 MDM2 CDK4
35 embryonal sarcoma 9.6 MDM2 CDK4 AXIN1
36 connective tissue benign neoplasm 9.6 MDM2 CDK4
37 lipomatosis, multiple 9.5 MDM2 CDK4
38 chondrosarcoma 9.5 MDM2 CDK4 BMP2
39 anaplastic astrocytoma 9.5 NOTCH1 MDM2 CDK4
40 malignant astrocytoma 9.4 NOTCH1 MDM2 CDK4
41 osteogenic sarcoma 9.4 MDM2 CDK4 BMP2
42 mantle cell lymphoma 9.4 NOTCH1 MDM2 CDK4
43 brain cancer 9.4 NOTCH1 MDM2 AXIN1
44 medulloblastoma 9.1 NOTCH1 MDM2 CDK4 BMP2 AXIN1

Graphical network of the top 20 diseases related to Adult Liposarcoma:



Diseases related to Adult Liposarcoma

Symptoms & Phenotypes for Adult Liposarcoma

GenomeRNAi Phenotypes related to Adult Liposarcoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Reduced mammosphere formation GR00396-S 9.02 ADAR CDK4 HNF4A MDM2 NOTCH1

MGI Mouse Phenotypes related to Adult Liposarcoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.01 ADAR AXIN1 BMP2 BTRC CDK4 HNF4A
2 cellular MP:0005384 9.97 ADAR AXIN1 BMP2 BTRC CDK4 HNF4A
3 digestive/alimentary MP:0005381 9.8 AXIN1 BMP2 BTRC CDH17 CDK4 MDM2
4 craniofacial MP:0005382 9.72 AXIN1 BMP2 CDK4 MDM2 NOTCH1
5 embryo MP:0005380 9.7 ADAR AXIN1 BMP2 CDK4 HNF4A MDM2
6 liver/biliary system MP:0005370 9.35 ADAR CDK4 HNF4A MDM2 NOTCH1
7 normal MP:0002873 9.1 AXIN1 BMP2 CDK4 HNF4A MDM2 NOTCH1

Drugs & Therapeutics for Adult Liposarcoma

Drugs for Adult Liposarcoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 45)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Doxorubicin Approved, Investigational Phase 3 23214-92-8 31703
2
Lenograstim Approved, Investigational Phase 3 135968-09-1
3
Ifosfamide Approved Phase 3 3778-73-2 3690
4
Etoposide Approved Phase 3 33419-42-0 36462
5 Antibiotics, Antitubercular Phase 3
6 Anti-Bacterial Agents Phase 3
7
Liposomal doxorubicin Phase 3 31703
8
Isophosphamide mustard Phase 3 100427
9 Alkylating Agents Phase 3
10 Etoposide phosphate Phase 3
11
Temozolomide Approved, Investigational Phase 2 85622-93-1 5394
12
Rosiglitazone Approved, Investigational Phase 2 122320-73-4 77999
13
Sorafenib Approved, Investigational Phase 2 284461-73-0 216239 406563
14
Trabectedin Approved, Investigational Phase 2 114899-77-3 108150
15
Sunitinib Approved, Investigational Phase 2 341031-54-7, 557795-19-4 5329102
16
Topotecan Approved, Investigational Phase 2 119413-54-6, 123948-87-8 60700
17
Nelfinavir Approved Phase 1, Phase 2 159989-64-7 64143
18 Exatecan Investigational Phase 2 171335-80-1
19
Maleic acid Experimental Phase 2 110-16-7 444266
20 Soblidotin Investigational Phase 2 149606-27-9
21 Protein Kinase Inhibitors Phase 1, Phase 2
22 Imatinib Mesylate Phase 1, Phase 2 220127-57-1 123596
23 Hypoglycemic Agents Phase 2
24 Immunosuppressive Agents Phase 2
25 Angiogenesis Inhibitors Phase 2
26 topoisomerase I inhibitors Phase 2
27 Anti-HIV Agents Phase 1, Phase 2
28 Anti-Infective Agents Phase 1, Phase 2
29 HIV Protease Inhibitors Phase 1, Phase 2
30 Anti-Retroviral Agents Phase 1, Phase 2
31 Antiviral Agents Phase 1, Phase 2
32
protease inhibitors Phase 1, Phase 2
33
Sargramostim Approved, Investigational Phase 1 123774-72-1, 83869-56-1
34
Celecoxib Approved, Investigational Phase 1 169590-42-5 2662
35
Cyclophosphamide Approved, Investigational Phase 1 50-18-0, 6055-19-2 2907
36 Molgramostim Investigational Phase 1 99283-10-0
37 Immunologic Factors Phase 1
38 Vaccines Phase 1
39 Anti-Inflammatory Agents Phase 1
40 Analgesics, Non-Narcotic Phase 1
41 Cyclooxygenase 2 Inhibitors Phase 1
42 Anti-Inflammatory Agents, Non-Steroidal Phase 1
43 Analgesics Phase 1
44 Antirheumatic Agents Phase 1
45 Cyclooxygenase Inhibitors Phase 1

Interventional clinical trials:

(show all 29)
# Name Status NCT ID Phase Drugs
1 A Phase III Randomized Study of Preoperative Radiotherapy Plus Surgery Versus Surgery Alone for Patients With Retroperitoneal Sarcoma (RPS) Unknown status NCT01344018 Phase 3
2 Randomised Trial of Post-Operative Radiotherapy Given to Adult Patients With Extremity Soft Tissue Sarcoma [VORTEX] Completed NCT00423618 Phase 3
3 METASTASECTOMY AND CHEMOTHERAPY FOR LUNG METASTASES FROM SOFT TISSUE SARCOMA: A RANDOMIZED PHASE III STUDY (AN INTERGROUP STUDY WITH THE SCANDINAVIAN SARCOMA GROUP) Completed NCT00002764 Phase 3 doxorubicin hydrochloride;ifosfamide
4 Randomised Trial Of Single Agent Doxorubicin Versus Doxorubicin Plus Ifosfamide In The First Line Treatment Of Advanced Or Metastatic Soft Tissue Sarcoma Completed NCT00061984 Phase 3 doxorubicin hydrochloride;ifosfamide
5 Randomized Study Comparing Neoadjuvant Chemotherapy Etoposide + Ifosfamide + Adriamycin (EIA) Combined With Regional Hyperthermia (RHT) Versus Neoadjuvant Chemotherapy Alone in the Treatment of High-Risk Soft Tissue Sarcomas in Adults Completed NCT00003052 Phase 3 doxorubicin hydrochloride;etoposide;ifosfamide
6 RANDOMISED TRIAL OF ADJUVANT CHEMOTHERAPY WITH HIGH-DOSE DOXORUBICIN, IFOSFAMIDE AND LENOGRASTIM IN HIGH GRADE SOFT TISSUE SARCOMA Completed NCT00002641 Phase 3 doxorubicin hydrochloride;ifosfamide;isolated perfusion
7 A Phase III Randomized Study of Preoperative Radiation Plus Surgery Versus Surgery Alone for Patients With Retroperitoneal Sarcomas (RPS) Completed NCT00091351 Phase 3
8 Randomized Phase III Trial of Two Investigational Schedules of Ifosfamide vs. Standard Dose Doxorubicin in Patients With Advanced or Metastatic Soft Tissue Sarcoma Completed NCT00003212 Phase 3 doxorubicin hydrochloride;ifosfamide
9 Randomized Phase II Study of Brostallicin (PNU-166196A) Versus Doxorubicin as First Line Chemotherapy in Patients With Advanced or Metastatic Soft Tissue Sarcoma Unknown status NCT00410462 Phase 2 brostallicin;doxorubicin hydrochloride
10 Phase II Evaluation of Temodal (Temozolomide, Schering) in Previously Treated Advanced Sarcomas Unknown status NCT00003718 Phase 2 temozolomide
11 Efficacy And Safety Study Of Brostallicin In Patients With Locally Advanced Or Metastatic Soft Tissue Sarcoma Failing One Prior Chemotherapy Treatment Completed NCT00041249 Phase 2 brostallicin
12 Dose Finding and Phase II Study of STI 571 in Advanced Soft Tissue Sarcoma Completed NCT00006357 Phase 1, Phase 2 imatinib mesylate
13 A Phase II Study Of Perifosine (D-21266) In Patients With Previously Untreated Metastatic Or Locally Advanced Soft Tissue Sarcoma Completed NCT00053794 Phase 2 perifosine
14 Exatecan As Second-Line Treatment In Advanced Adult Soft Tissue Sarcoma: A Phase II - Study Of The EORTC Soft Tissue And Bone Sarcoma Group Completed NCT00041236 Phase 2 exatecan mesylate
15 Phase II Clinical Trial of Rosiglitazone, a Full-Agonist Ligand for the Peroxisome Proliferator-Activated Receptor Gamma (PPAR), as Differentiation Therapy for Patients With Liposarcoma Completed NCT00004180 Phase 2 rosiglitazone maleate
16 Phase II Trial of BAY-9006 (NSC #724772) in Advanced Soft Tissue Sarcomas Completed NCT00217620 Phase 2 sorafenib
17 A Phase II Study of Intravenous TZT-1027, Administered Weekly Times Two, Every Three Weeks, to Patients With Advanced or Metastatic Soft Tissue Sarcomas (STS) With Prior Exposure to Anthracycline-Based Chemotherapy Completed NCT00064220 Phase 2 soblidotin
18 Phase II Study on ET-743 in Advanced Soft Tissue Sarcomas of the Adult Completed NCT00003939 Phase 2 trabectedin
19 Phase II Clinical Trial of TROGLITAZONE, a Ligand for the Peroxisome Proliferator-Activated Receptor Gamma (PPAR), as Antineoplastic Differentiation Therapy for Patients With Malignant Liposarcoma Completed NCT00003058 Phase 2 troglitazone
20 Multicenter Parallel Phase II Trial of BI 2536 Administered as One Hour IV Infusion Every 3 Weeks in Defined Cohorts of Patients With Various Solid Tumors. A New Drug Screening Program of the EORTC Network of Core Institutions (NOCI) Completed NCT00526149 Phase 2 BI 2536
21 A Multicenter Phase II Study of Continuous Dosing of Sunitinib (Sutent®, SU11248) in Non-GIST Sarcomas Completed NCT00474994 Phase 2 sunitinib malate
22 A Phase II Study of Pazopanib With Oral Topotecan in Patients With Metastatic and Non-resectable Soft Tissue and Bone Sarcomas Active, not recruiting NCT02357810 Phase 2 Pazopanib Hydrochloride;Oral Topotecan Hydrochloride
23 A Phase I/II Study of Nelfinavir in Liposarcoma Terminated NCT00233948 Phase 1, Phase 2 nelfinavir mesylate
24 A Phase I Study Of Vaccination With Telomerase Peptide Plus GM-CSF Completed NCT00069940 Phase 1
25 A Phase I Study of Preoperative Chemoradiation and Intraoperative Radiation Therapy in the Treatment of Retroperitoneal Sarcoma Completed NCT00004123 Phase 1 Doxorubicin hydrochloride (DOX)
26 Phase I Study To Determine The Safety Of Caelyx (Doxorubin HCI, Pegylated Liposomal) In Combination With Ifosfamide In Previously Untreated Adult Patients With Advanced And/Or Metastatic Soft Tissues Sarcomas Completed NCT00030784 Phase 1 ifosfamide;pegylated liposomal doxorubicin hydrochloride
27 A Phase I Trial of Postoperative Radiation With Dose-Escalation of A Cox-2 Inhibitor, Celebrex™ (CELECOXIB) in Patients With Soft Tissue Sarcoma of the Extremity Completed NCT00450736 Phase 1 celecoxib
28 A Phase I Study To Determine the Feasibility of Using Autologous NY-ESO-1 Specific CD8+ T Cells For the Treatment of Patients With Advanced Myxoid/ Round Cell Liposarcoma and Synovial Sarcoma. Completed NCT01477021 Phase 1 cyclophosphamide
29 VORTEX-BIOBANK: Prospective Sample Collection for the VORTEX Randomised Radiotherapy Trial in Patients With Extremity Soft Tissue Sarcoma [VORTEX BIOBANK] Unknown status NCT00900211

Search NIH Clinical Center for Adult Liposarcoma

Genetic Tests for Adult Liposarcoma

Anatomical Context for Adult Liposarcoma

MalaCards organs/tissues related to Adult Liposarcoma:

40
Bone, T Cells

Publications for Adult Liposarcoma

Articles related to Adult Liposarcoma:

# Title Authors PMID Year
1
Childhood liposarcoma. Report of a case and review of the literature. 61
6733687 1984
2
Liposarcoma occurring in children. An analysis of 17 cases and review of the literature. 61
6861094 1983

Variations for Adult Liposarcoma

Expression for Adult Liposarcoma

Search GEO for disease gene expression data for Adult Liposarcoma.

Pathways for Adult Liposarcoma

Pathways related to Adult Liposarcoma according to GeneCards Suite gene sharing:

(show all 17)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.34 NOTCH1 MDM2 HNF4A CDK4 CDH17 BMP2
2
Show member pathways
12.66 NOTCH1 MDM2 CDK4 AXIN1
3 12.38 NOTCH1 MDM2 CDK4 BMP2 AXIN1
4
Show member pathways
12.37 NOTCH1 CDK4 CDH17 AXIN1
5
Show member pathways
12.17 HNF4A BMP2 AXIN1
6
Show member pathways
11.99 MDM2 BMP2 AXIN1
7 11.83 BTRC BMP2 AXIN1
8 11.8 MDM2 CDK4 BTRC
9 11.59 MDM2 CDK4 AXIN1
10 11.42 HNF4A CDK4 CDH17 BTRC AXIN1
11 11.41 NOTCH1 CDH17 BTRC AXIN1
12 11.39 MDM2 BMP2 AXIN1
13 11.23 MDM2 CDK4
14 11.22 NOTCH1 BMP2
15 11.18 MDM2 CDK4
16 11.02 MDM2 CDK4
17 10.99 NOTCH1 BTRC AXIN1

GO Terms for Adult Liposarcoma

Cellular components related to Adult Liposarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nucleoplasm GO:0005654 9.23 NOTCH1 MYCBP MDM2 HNF4A CDK4 CDH17

Biological processes related to Adult Liposarcoma according to GeneCards Suite gene sharing:

(show all 19)
# Name GO ID Score Top Affiliating Genes
1 heart development GO:0007507 9.72 NOTCH1 MDM2 BMP2
2 negative regulation of transcription, DNA-templated GO:0045892 9.72 NOTCH1 MDM2 HNF4A BTRC BMP2
3 negative regulation of canonical Wnt signaling pathway GO:0090090 9.7 NOTCH1 BMP2 AXIN1
4 transcription initiation from RNA polymerase II promoter GO:0006367 9.67 NOTCH1 HNF4A CDK4
5 positive regulation of transcription, DNA-templated GO:0045893 9.63 NOTCH1 MYCBP HNF4A BTRC BMP2 AXIN1
6 positive regulation of epithelial to mesenchymal transition GO:0010718 9.58 NOTCH1 BMP2
7 animal organ regeneration GO:0031100 9.58 NOTCH1 CDK4
8 epithelial to mesenchymal transition GO:0001837 9.57 NOTCH1 BMP2
9 positive regulation of cell cycle GO:0045787 9.56 MDM2 CDK4
10 positive regulation of viral genome replication GO:0045070 9.54 NOTCH1 ADAR
11 cellular response to organic cyclic compound GO:0071407 9.54 MDM2 BTRC BMP2
12 negative regulation of cell cycle arrest GO:0071157 9.51 MDM2 CDK4
13 cardiac septum morphogenesis GO:0060411 9.48 NOTCH1 MDM2
14 cardiac epithelial to mesenchymal transition GO:0060317 9.46 NOTCH1 BMP2
15 cardiac muscle tissue morphogenesis GO:0055008 9.43 NOTCH1 BMP2
16 protein destabilization GO:0031648 9.43 MDM2 BTRC BMP2
17 positive regulation of astrocyte differentiation GO:0048711 9.4 NOTCH1 BMP2
18 endocardial cushion morphogenesis GO:0003203 9.13 NOTCH1 MDM2 BMP2
19 atrioventricular valve morphogenesis GO:0003181 8.8 NOTCH1 MDM2 BMP2

Sources for Adult Liposarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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