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MCID: ADL015
MIFTS: 35

Adult Liposarcoma

Categories: Cancer diseases, Rare diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Adult Liposarcoma

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MalaCards integrated aliases for Adult Liposarcoma:

Name: Adult Liposarcoma 12 15 71

Classifications:

MalaCards categories:
Global: Cancer diseases Rare diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:5693
NCIt 49 C7811
UMLS 71 C0278608
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Summaries for Adult Liposarcoma

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MalaCards based summary : Adult Liposarcoma is related to well-differentiated liposarcoma and myxoid liposarcoma. An important gene associated with Adult Liposarcoma is MYCBP (MYC Binding Protein), and among its related pathways/superpathways are ERK Signaling and Nanog in Mammalian ESC Pluripotency. The drugs Mechlorethamine and Doxorubicin have been mentioned in the context of this disorder. Affiliated tissues include bone, lung and t cells, and related phenotypes are Reduced mammosphere formation and cardiovascular system

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Related Diseases for Adult Liposarcoma

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Diseases in the Liposarcoma family:

Adult Liposarcoma Inflammatory Liposarcoma

Diseases related to Adult Liposarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 66)
# Related Disease Score Top Affiliating Genes
1 well-differentiated liposarcoma 28.8 MDM2 CDK4
2 myxoid liposarcoma 11.3
3 adult hepatocellular carcinoma 10.2 CTNNB1 AXIN1
4 hair follicle neoplasm 10.1 CTNNB1 AXIN1
5 ring chromosome 7 10.0 MDM2 CDK4
6 ring chromosome 10.0 MDM2 CDK4
7 mediastinum liposarcoma 10.0 MDM2 CDK4
8 gastric liposarcoma 10.0 MDM2 CDK4
9 diffuse lipomatosis 10.0 MDM2 CDK4
10 undifferentiated embryonal sarcoma of the liver 10.0 MDM2 CDK4
11 spindle cell liposarcoma 10.0 MDM2 CDK4
12 pediatric liposarcoma 10.0 MDM2 CDK4
13 infiltrating lipoma 10.0 MDM2 CDK4
14 lipoblastoma 9.9 MDM2 CDK4
15 mediastinum sarcoma 9.9 MDM2 CDK4
16 liposarcoma of bone 9.9 MDM2 CDK4
17 inflammatory mfh 9.9 MDM2 CDK4
18 pancreas sarcoma 9.9 MDM2 CDK4
19 conventional fibrosarcoma 9.9 MDM2 CTNNB1
20 juxtacortical osteosarcoma 9.9 MDM2 CDK4
21 paratesticular lipoma 9.9 MDM2 CDK4
22 lipoma of spermatic cord 9.9 MDM2 CDK4
23 pleomorphic lipoma 9.9 MDM2 CDK4
24 peripheral osteosarcoma 9.9 MDM2 CDK4
25 extraosseous osteosarcoma 9.9 MDM2 CDK4
26 mixed liposarcoma 9.9 MDM2 CDK4
27 retroperitoneal sarcoma 9.9 MDM2 CDK4
28 pilomatrixoma 9.9 CTNNB1 BMP2 AXIN1
29 infiltrating angiolipoma 9.9 MDM2 CDK4
30 parameningeal embryonal rhabdomyosarcoma 9.9 MDM2 CDK4
31 dedifferentiated liposarcoma 9.9 MDM2 CDK4
32 cellular myxoid liposarcoma 9.9 MDM2 CDK4
33 intestinal benign neoplasm 9.8 HNF4A CTNNB1 AXIN1
34 ischemic fasciitis 9.8 MDM2 CDK4
35 familial retinoblastoma 9.8 MDM2 CDK4
36 osteoporosis-pseudoglioma syndrome 9.8 CTNNB1 AXIN1
37 pleomorphic adenoma 9.7 MDM2 CTNNB1 BMP2
38 pleomorphic liposarcoma 9.7 MDM2 CDK4
39 breast liposarcoma 9.7 NOTCH1 CDK4
40 bone squamous cell carcinoma 9.7 NOTCH1 CTNNB1
41 uterine adnexa cancer 9.6 NOTCH1 MDM2
42 bone osteosarcoma 9.6 MDM2 CDK4
43 familial adenomatous polyposis 9.6 HNF4A GSK3B CTNNB1 AXIN1
44 liposarcoma 9.6 MDM2 CTNNB1 CDK4
45 chondrosarcoma 9.6 MDM2 CDK4 BMP2
46 connective tissue benign neoplasm 9.6 MDM2 CTNNB1 CDK4
47 ossifying fibroma 9.6 NOTCH1 MDM2
48 lung acinar adenocarcinoma 9.5 HNF4A CTNNB1 CDH17 AXIN1
49 li-fraumeni syndrome 9.5 MDM2 CTNNB1 CDK4
50 bone cancer 9.5 NOTCH1 CTNNB1 BMP2

Graphical network of the top 20 diseases related to Adult Liposarcoma:



Diseases related to Adult Liposarcoma
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Symptoms & Phenotypes for Adult Liposarcoma

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GenomeRNAi Phenotypes related to Adult Liposarcoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Reduced mammosphere formation GR00396-S 9.1 ADAR CDK4 GSK3B HNF4A MDM2 NOTCH1

MGI Mouse Phenotypes related to Adult Liposarcoma:

45 (show all 14)
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.19 ADAR AXIN1 BMP2 CDK4 CTNNB1 GSK3B
2 cellular MP:0005384 10.18 ADAR AXIN1 BMP2 CDK4 CTNNB1 GSK3B
3 growth/size/body region MP:0005378 10.11 ADAR AXIN1 BMP2 CDK4 CTNNB1 GSK3B
4 digestive/alimentary MP:0005381 10.1 AXIN1 BMP2 CDH17 CDK4 CTNNB1 GSK3B
5 embryo MP:0005380 10.08 ADAR AXIN1 BMP2 CDK4 CTNNB1 HNF4A
6 craniofacial MP:0005382 10.05 AXIN1 BMP2 CDK4 CTNNB1 GSK3B MDM2
7 immune system MP:0005387 10.03 ADAR BMP2 CDH17 CDK4 CTNNB1 GSK3B
8 mortality/aging MP:0010768 10.02 ADAR AXIN1 BMP2 CDK4 CTNNB1 GSK3B
9 nervous system MP:0003631 9.97 ADAR AXIN1 BMP2 CDK4 CTNNB1 GSK3B
10 liver/biliary system MP:0005370 9.95 ADAR CDK4 CTNNB1 GSK3B HNF4A MDM2
11 normal MP:0002873 9.86 AXIN1 BMP2 CDK4 CTNNB1 GSK3B HNF4A
12 pigmentation MP:0001186 9.46 CDK4 CTNNB1 MDM2 NOTCH1
13 renal/urinary system MP:0005367 9.43 AXIN1 CDK4 CTNNB1 GSK3B MDM2 NOTCH1
14 skeleton MP:0005390 9.28 ADAR AXIN1 BMP2 CDK4 CTNNB1 GSK3B
Sources

Drugs & Therapeutics for Adult Liposarcoma

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Drugs for Adult Liposarcoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 47)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Mechlorethamine Approved, Investigational Phase 3 51-75-2 4033
2
Doxorubicin Approved, Investigational Phase 3 23214-92-8 31703
3
Ifosfamide Approved Phase 3 3778-73-2 3690
4
Lenograstim Approved, Investigational Phase 3 135968-09-1
5
Etoposide Approved Phase 3 33419-42-0 36462
6 Alkylating Agents Phase 3
7 Topoisomerase Inhibitors Phase 3
8 Anti-Bacterial Agents Phase 3
9 Antibiotics, Antitubercular Phase 3
10
Liposomal doxorubicin Phase 3 31703
11
Isophosphamide mustard Phase 3 0
12 Etoposide phosphate Phase 3
13
Temozolomide Approved, Investigational Phase 2 85622-93-1 5394
14
Rosiglitazone Approved, Investigational Phase 2 122320-73-4 77999
15
Trabectedin Approved, Investigational Phase 2 114899-77-3 108150
16
Sorafenib Approved, Investigational Phase 2 284461-73-0 216239 406563
17
Sunitinib Approved, Investigational Phase 2 557795-19-4, 341031-54-7 5329102
18
Topotecan Approved, Investigational Phase 2 123948-87-8, 119413-54-6 60700
19
Nelfinavir Approved Phase 1, Phase 2 159989-64-7 64143
20
Maleic acid Experimental, Investigational Phase 2 110-17-8, 110-16-7 444972
21 Exatecan Investigational Phase 2 171335-80-1
22
Camptothecin Experimental Phase 2 7689-03-4
23 Soblidotin Investigational Phase 2 149606-27-9
24 Hypoglycemic Agents Phase 2
25 Immunosuppressive Agents Phase 2
26 Protein Kinase Inhibitors Phase 2
27 Angiogenesis Inhibitors Phase 2
28 Imatinib Mesylate Phase 1, Phase 2 220127-57-1 123596
29 topoisomerase I inhibitors Phase 2
30
protease inhibitors Phase 1, Phase 2
31 HIV Protease Inhibitors Phase 1, Phase 2
32 Anti-Retroviral Agents Phase 1, Phase 2
33 Anti-Infective Agents Phase 1, Phase 2
34 Anti-HIV Agents Phase 1, Phase 2
35 Antiviral Agents Phase 1, Phase 2
36
Cyclophosphamide Approved, Investigational Phase 1 6055-19-2, 50-18-0 2907
37
Celecoxib Approved, Investigational Phase 1 169590-42-5 2662
38
Sargramostim Approved, Investigational Phase 1 83869-56-1, 123774-72-1
39 Immunologic Factors Phase 1
40 Antirheumatic Agents Phase 1
41 Anti-Inflammatory Agents Phase 1
42 Cyclooxygenase 2 Inhibitors Phase 1
43 Anti-Inflammatory Agents, Non-Steroidal Phase 1
44 Analgesics, Non-Narcotic Phase 1
45 Analgesics Phase 1
46 Cyclooxygenase Inhibitors Phase 1
47 Vaccines Phase 1

Interventional clinical trials:

(show all 29)
# Name Status NCT ID Phase Drugs
1 A Phase III Randomized Study of Preoperative Radiotherapy Plus Surgery Versus Surgery Alone for Patients With Retroperitoneal Sarcoma (RPS) Unknown status NCT01344018 Phase 3
2 Randomised Trial of Post-Operative Radiotherapy Given to Adult Patients With Extremity Soft Tissue Sarcoma [VORTEX] Completed NCT00423618 Phase 3
3 METASTASECTOMY AND CHEMOTHERAPY FOR LUNG METASTASES FROM SOFT TISSUE SARCOMA: A RANDOMIZED PHASE III STUDY (AN INTERGROUP STUDY WITH THE SCANDINAVIAN SARCOMA GROUP) Completed NCT00002764 Phase 3 doxorubicin hydrochloride;ifosfamide
4 Randomized Phase III Trial of Two Investigational Schedules of Ifosfamide vs. Standard Dose Doxorubicin in Patients With Advanced or Metastatic Soft Tissue Sarcoma Completed NCT00003212 Phase 3 doxorubicin hydrochloride;ifosfamide
5 Randomized Study Comparing Neoadjuvant Chemotherapy Etoposide + Ifosfamide + Adriamycin (EIA) Combined With Regional Hyperthermia (RHT) Versus Neoadjuvant Chemotherapy Alone in the Treatment of High-Risk Soft Tissue Sarcomas in Adults Completed NCT00003052 Phase 3 doxorubicin hydrochloride;etoposide;ifosfamide
6 A Phase III Randomized Study of Preoperative Radiation Plus Surgery Versus Surgery Alone for Patients With Retroperitoneal Sarcomas (RPS) Completed NCT00091351 Phase 3
7 Randomised Trial Of Single Agent Doxorubicin Versus Doxorubicin Plus Ifosfamide In The First Line Treatment Of Advanced Or Metastatic Soft Tissue Sarcoma Completed NCT00061984 Phase 3 doxorubicin hydrochloride;ifosfamide
8 RANDOMISED TRIAL OF ADJUVANT CHEMOTHERAPY WITH HIGH-DOSE DOXORUBICIN, IFOSFAMIDE AND LENOGRASTIM IN HIGH GRADE SOFT TISSUE SARCOMA Completed NCT00002641 Phase 3 doxorubicin hydrochloride;ifosfamide;isolated perfusion
9 Phase II Evaluation of Temodal (Temozolomide, Schering) in Previously Treated Advanced Sarcomas Unknown status NCT00003718 Phase 2 temozolomide
10 Randomized Phase II Study of Brostallicin (PNU-166196A) Versus Doxorubicin as First Line Chemotherapy in Patients With Advanced or Metastatic Soft Tissue Sarcoma Unknown status NCT00410462 Phase 2 brostallicin;doxorubicin hydrochloride
11 Phase II Clinical Trial of Rosiglitazone, a Full-Agonist Ligand for the Peroxisome Proliferator-Activated Receptor Gamma (PPAR), as Differentiation Therapy for Patients With Liposarcoma Completed NCT00004180 Phase 2 rosiglitazone maleate
12 Phase II Study on ET-743 in Advanced Soft Tissue Sarcomas of the Adult Completed NCT00003939 Phase 2 trabectedin
13 Phase II Clinical Trial of TROGLITAZONE, a Ligand for the Peroxisome Proliferator-Activated Receptor Gamma (PPAR), as Antineoplastic Differentiation Therapy for Patients With Malignant Liposarcoma Completed NCT00003058 Phase 2 troglitazone
14 Exatecan As Second-Line Treatment In Advanced Adult Soft Tissue Sarcoma: A Phase II - Study Of The EORTC Soft Tissue And Bone Sarcoma Group Completed NCT00041236 Phase 2 exatecan mesylate
15 Phase II Trial of BAY-9006 (NSC #724772) in Advanced Soft Tissue Sarcomas Completed NCT00217620 Phase 2 sorafenib
16 A Phase II Study of Intravenous TZT-1027, Administered Weekly Times Two, Every Three Weeks, to Patients With Advanced or Metastatic Soft Tissue Sarcomas (STS) With Prior Exposure to Anthracycline-Based Chemotherapy Completed NCT00064220 Phase 2 soblidotin
17 A Phase II Study Of Perifosine (D-21266) In Patients With Previously Untreated Metastatic Or Locally Advanced Soft Tissue Sarcoma Completed NCT00053794 Phase 2 perifosine
18 Efficacy And Safety Study Of Brostallicin In Patients With Locally Advanced Or Metastatic Soft Tissue Sarcoma Failing One Prior Chemotherapy Treatment Completed NCT00041249 Phase 2 brostallicin
19 A Multicenter Phase II Study of Continuous Dosing of Sunitinib (Sutent®, SU11248) in Non-GIST Sarcomas Completed NCT00474994 Phase 2 sunitinib malate
20 Multicenter Parallel Phase II Trial of BI 2536 Administered as One Hour IV Infusion Every 3 Weeks in Defined Cohorts of Patients With Various Solid Tumors. A New Drug Screening Program of the EORTC Network of Core Institutions (NOCI) Completed NCT00526149 Phase 2 BI 2536
21 Dose Finding and Phase II Study of STI 571 in Advanced Soft Tissue Sarcoma Completed NCT00006357 Phase 1, Phase 2 imatinib mesylate
22 A Phase II Study of Pazopanib With Oral Topotecan in Patients With Metastatic and Non-resectable Soft Tissue and Bone Sarcomas Recruiting NCT02357810 Phase 2 Pazopanib Hydrochloride;Oral Topotecan Hydrochloride
23 A Phase I/II Study of Nelfinavir in Liposarcoma Terminated NCT00233948 Phase 1, Phase 2 nelfinavir mesylate
24 A Phase I Study To Determine the Feasibility of Using Autologous NY-ESO-1 Specific CD8+ T Cells For the Treatment of Patients With Advanced Myxoid/ Round Cell Liposarcoma and Synovial Sarcoma. Completed NCT01477021 Phase 1 cyclophosphamide
25 Phase I Study To Determine The Safety Of Caelyx (Doxorubin HCI, Pegylated Liposomal) In Combination With Ifosfamide In Previously Untreated Adult Patients With Advanced And/Or Metastatic Soft Tissues Sarcomas Completed NCT00030784 Phase 1 ifosfamide;pegylated liposomal doxorubicin hydrochloride
26 A Phase I Trial of Postoperative Radiation With Dose-Escalation of A Cox-2 Inhibitor, Celebrexâ„¢ (CELECOXIB) in Patients With Soft Tissue Sarcoma of the Extremity Completed NCT00450736 Phase 1 celecoxib
27 A Phase I Study of Preoperative Chemoradiation and Intraoperative Radiation Therapy in the Treatment of Retroperitoneal Sarcoma Completed NCT00004123 Phase 1 Doxorubicin hydrochloride (DOX)
28 A Phase I Study Of Vaccination With Telomerase Peptide Plus GM-CSF Completed NCT00069940 Phase 1
29 VORTEX-BIOBANK: Prospective Sample Collection for the VORTEX Randomised Radiotherapy Trial in Patients With Extremity Soft Tissue Sarcoma [VORTEX BIOBANK] Unknown status NCT00900211

Search NIH Clinical Center for Adult Liposarcoma

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Genetic Tests for Adult Liposarcoma

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Anatomical Context for Adult Liposarcoma

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MalaCards organs/tissues related to Adult Liposarcoma:

40
Bone, Lung, T Cells
Sources

Publications for Adult Liposarcoma

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Articles related to Adult Liposarcoma:

# Title Authors PMID Year
1
Childhood liposarcoma. Report of a case and review of the literature. 61
6733687 1984
2
Liposarcoma occurring in children. An analysis of 17 cases and review of the literature. 61
6861094 1983
Sources

Variations for Adult Liposarcoma

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Expression for Adult Liposarcoma

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Search GEO for disease gene expression data for Adult Liposarcoma.
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Pathways for Adult Liposarcoma

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Pathways related to Adult Liposarcoma according to GeneCards Suite gene sharing:

(show all 45)
# Super pathways Score Top Affiliating Genes
1
ERK Signaling 63
Show member pathways
 13.53 NOTCH1 MDM2 HNF4A GSK3B CTNNB1 CDK4
2
Nanog in Mammalian ESC Pluripotency 63
Show member pathways
 13.12 GSK3B CTNNB1 CDH17 BMP2 AXIN1
3
PI3K-Akt signaling pathway 36
Show member pathways
 12.82 NOTCH1 MDM2 GSK3B CTNNB1 CDK4 AXIN1
4
Human cytomegalovirus infection 36
Show member pathways
 12.79 MDM2 GSK3B CTNNB1 CDK4
5
Sertoli-Sertoli Cell Junction Dynamics 63
Show member pathways
 12.78 GSK3B CTNNB1 CDK4 AXIN1
6
Aldosterone synthesis and secretion 36
Show member pathways
 12.76 GSK3B CTNNB1 CDK4 AXIN1
7
Endometrial cancer 36
Show member pathways
 12.74 MDM2 GSK3B CTNNB1 CDK4 AXIN1
8
Measles 36
Show member pathways
 12.67 MDM2 GSK3B CDK4 ADAR
9
Gastric cancer 36
Show member pathways
 12.51 NOTCH1 GSK3B CTNNB1 CDK4 CDH17 AXIN1
10
Notch Signaling Pathway (WikiPathways) 1
Show member pathways
 12.43 NOTCH1 MYCBP GSK3B CTNNB1
11
Wnt Signaling Pathways: beta-Catenin-dependent Wnt Signaling 64
Show member pathways
 12.41 GSK3B CTNNB1 BMP2 AXIN1
12
Mesodermal Commitment Pathway 1
Show member pathways
 12.39 NOTCH1 HNF4A CTNNB1 AXIN1
13
Human Embryonic Stem Cell Pluripotency 63
Show member pathways
 12.3 HNF4A GSK3B CTNNB1 BMP2 AXIN1
14
p53 Signaling 63
Show member pathways
 12.13 MDM2 GSK3B CDK4
15
Wnt / Hedgehog / Notch 4
12.13 NOTCH1 GSK3B CTNNB1 AXIN1
16
Wnt Signaling Pathway and Pluripotency 1
Show member pathways
 12.1 GSK3B CTNNB1 AXIN1
17
Hippo signaling pathway 36
12.04 GSK3B CTNNB1 BMP2 AXIN1
18
WNT Signaling 63
12.03 HNF4A GSK3B CTNNB1 CDK4 CDH17 AXIN1
19
Integrated Breast Cancer Pathway 1
12.02 MDM2 CTNNB1 CDK4
20
Transcription Androgen Receptor nuclear signaling 22
Show member pathways
 11.99 MDM2 GSK3B CTNNB1
21
Brain-Derived Neurotrophic Factor (BDNF) signaling pathway 1
11.98 GSK3B CTNNB1 BMP2
22
Signaling pathways regulating pluripotency of stem cells 36
11.96 GSK3B CTNNB1 AXIN1
23
G12-G13 in Cellular Signaling 63
11.93 GSK3B CTNNB1 CDH17 AXIN1
24
Thyroid hormone signaling pathway 36
11.9 NOTCH1 MDM2 GSK3B CTNNB1
25
Pathways in cancer 36
11.89 NOTCH1 MDM2 GSK3B CTNNB1 CDK4 BMP2
26
DNA Damage Response (only ATM dependent) 1
11.86 MDM2 GSK3B CTNNB1 AXIN1
27
Reelin Pathway (Cajal-Retzius cells) 63
11.83 GSK3B CTNNB1 AXIN1
28
Senescence and Autophagy in Cancer 1
11.83 MDM2 GSK3B BMP2
29
Presenilin-Mediated Signaling 63
11.81 NOTCH1 GSK3B CTNNB1 CDH17 AXIN1
30
Neural Crest Differentiation 1
11.79 NOTCH1 GSK3B CTNNB1 AXIN1
31
Androgen receptor signaling pathway 1
11.75 MDM2 GSK3B CTNNB1
32
Association Between Physico-Chemical Features and Toxicity Associated Pathways 1
11.61 GSK3B CTNNB1 AXIN1
33
Transcription_P53 signaling pathway 22
11.59 MDM2 CTNNB1 BMP2 AXIN1
34
Wnt Signaling Pathway Netpath 1
11.48 GSK3B CTNNB1 AXIN1
35
Heart Development 1
11.41 NOTCH1 CTNNB1 BMP2
36
Glioblastoma Multiforme 63
11.4 MDM2 GSK3B CTNNB1 CDK4 AXIN1
37
Presenilin action in Notch and Wnt signaling 1
11.29 NOTCH1 GSK3B CTNNB1 AXIN1
38
N-cadherin signaling events 1
11.21 CTNNB1 AXIN1
39
Oncogene Induced Senescence 65
11.19 MDM2 CDK4
40
Aurora A signaling 1
11.17 MDM2 GSK3B
41
Extracellular vesicle-mediated signaling in recipient cells 1
11.16 CTNNB1 AXIN1
42
Wnt/beta-catenin Signaling Pathway in Leukemia 1
11.05 GSK3B CTNNB1
43
C-MYC pathway 1
11 GSK3B AXIN1
44
Regulation of Wnt/B-catenin Signaling by Small Molecule Compounds 1
10.86 GSK3B CTNNB1 AXIN1
45
BMP2-WNT4-FOXO1 Pathway in Human Primary Endometrial Stromal Cell Differentiation 1
10.75 CTNNB1 BMP2
Sources

GO Terms for Adult Liposarcoma

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Cellular components related to Adult Liposarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nucleus GO:0005634 9.96 NOTCH1 MYCBP MDM2 HNF4A GSK3B CTNNB1
2 nucleoplasm GO:0005654 9.61 NOTCH1 MYCBP MDM2 HNF4A GSK3B CTNNB1
3 catenin complex GO:0016342 9.37 CTNNB1 CDH17
4 cell periphery GO:0071944 9.33 NOTCH1 CTNNB1 AXIN1
5 Wnt signalosome GO:1990909 9.32 GSK3B CTNNB1
6 beta-catenin destruction complex GO:0030877 8.8 GSK3B CTNNB1 AXIN1

Biological processes related to Adult Liposarcoma according to GeneCards Suite gene sharing:

(show all 35)
# Name GO ID Score Top Affiliating Genes
1 cell differentiation GO:0030154 10.01 NOTCH1 HNF4A GSK3B CTNNB1 BMP2
2 negative regulation of apoptotic process GO:0043066 9.95 MDM2 GSK3B CTNNB1 ADAR
3 positive regulation of cell proliferation GO:0008284 9.94 NOTCH1 MDM2 CTNNB1 CDK4
4 positive regulation of transcription, DNA-templated GO:0045893 9.92 NOTCH1 HNF4A CTNNB1 BMP2 AXIN1
5 negative regulation of cell proliferation GO:0008285 9.91 NOTCH1 HNF4A CTNNB1 BMP2
6 positive regulation of apoptotic process GO:0043065 9.88 NOTCH1 CTNNB1 CDK4 BMP2
7 negative regulation of transcription, DNA-templated GO:0045892 9.85 NOTCH1 MDM2 HNF4A CTNNB1 BMP2
8 regulation of cell proliferation GO:0042127 9.84 NOTCH1 CTNNB1 CDK4
9 negative regulation of gene expression GO:0010629 9.84 NOTCH1 MDM2 CTNNB1 BMP2
10 transcription initiation from RNA polymerase II promoter GO:0006367 9.81 NOTCH1 HNF4A CDK4
11 heart development GO:0007507 9.8 NOTCH1 MDM2 CTNNB1 BMP2
12 regulation of gene expression GO:0010468 9.78 NOTCH1 MDM2 CTNNB1 CDK4
13 positive regulation of gene expression GO:0010628 9.72 NOTCH1 MDM2 GSK3B CTNNB1 BMP2
14 cellular response to growth factor stimulus GO:0071363 9.69 MDM2 CTNNB1 BMP2
15 cell fate specification GO:0001708 9.67 NOTCH1 CTNNB1
16 negative regulation of canonical Wnt signaling pathway GO:0090090 9.67 NOTCH1 GSK3B BMP2 AXIN1
17 negative regulation of neurogenesis GO:0050768 9.66 NOTCH1 CTNNB1
18 embryonic hindlimb morphogenesis GO:0035116 9.65 NOTCH1 CTNNB1
19 positive regulation of viral genome replication GO:0045070 9.65 NOTCH1 ADAR
20 hair follicle morphogenesis GO:0031069 9.64 NOTCH1 CTNNB1
21 negative regulation of cell cycle arrest GO:0071157 9.63 MDM2 CDK4
22 positive regulation of neuroblast proliferation GO:0002052 9.62 NOTCH1 CTNNB1
23 positive regulation of protein export from nucleus GO:0046827 9.62 MDM2 GSK3B
24 positive regulation of endothelial cell differentiation GO:0045603 9.6 NOTCH1 CTNNB1
25 cardiac septum morphogenesis GO:0060411 9.59 NOTCH1 MDM2
26 cardiac muscle tissue morphogenesis GO:0055008 9.58 NOTCH1 BMP2
27 positive regulation of epithelial to mesenchymal transition GO:0010718 9.58 NOTCH1 CTNNB1 BMP2
28 cardiac epithelial to mesenchymal transition GO:0060317 9.57 NOTCH1 BMP2
29 negative regulation of oligodendrocyte differentiation GO:0048715 9.56 NOTCH1 CTNNB1
30 positive regulation of astrocyte differentiation GO:0048711 9.55 NOTCH1 BMP2
31 beta-catenin destruction complex assembly GO:1904885 9.43 GSK3B AXIN1
32 beta-catenin destruction complex disassembly GO:1904886 9.43 GSK3B CTNNB1 AXIN1
33 endocardial cushion morphogenesis GO:0003203 9.33 NOTCH1 MDM2 BMP2
34 atrioventricular valve morphogenesis GO:0003181 9.13 NOTCH1 MDM2 BMP2
35 epithelial to mesenchymal transition GO:0001837 8.92 NOTCH1 GSK3B CTNNB1 BMP2

Molecular functions related to Adult Liposarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 enzyme binding GO:0019899 9.46 NOTCH1 MDM2 CTNNB1 AXIN1
2 I-SMAD binding GO:0070411 8.96 CTNNB1 AXIN1
3 SMAD binding GO:0046332 8.8 CTNNB1 BMP2 AXIN1
Sources

Sources for Adult Liposarcoma

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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