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MCID: ADL015
MIFTS: 33

Adult Liposarcoma

Categories: Cancer diseases, Rare diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Adult Liposarcoma

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MalaCards integrated aliases for Adult Liposarcoma:

Name: Adult Liposarcoma 12 15 71

Classifications:

MalaCards categories:
Global: Cancer diseases Rare diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:5693
NCIt 49 C7811
UMLS 71 C0278608
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Summaries for Adult Liposarcoma

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MalaCards based summary : Adult Liposarcoma is related to pleomorphic lipoma and lipomatosis, multiple. An important gene associated with Adult Liposarcoma is MYCBP (MYC Binding Protein), and among its related pathways/superpathways are ERK Signaling and PI3K-Akt signaling pathway. The drugs Doxorubicin and Ifosfamide have been mentioned in the context of this disorder. Affiliated tissues include bone, lung and t cells, and related phenotypes are Reduced mammosphere formation and cardiovascular system

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Related Diseases for Adult Liposarcoma

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Diseases in the Liposarcoma family:

Adult Liposarcoma Inflammatory Liposarcoma

Diseases related to Adult Liposarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 49)
# Related Disease Score Top Affiliating Genes
1 pleomorphic lipoma 29.4 MDM2 CDK4
2 lipomatosis, multiple 28.9 MDM2 CDK4
3 myxoid liposarcoma 11.3
4 uterine adnexa cancer 9.8 NOTCH1 MDM2
5 liposarcoma 9.8
6 well-differentiated liposarcoma 9.8
7 breast liposarcoma 9.8 NOTCH1 CDK4
8 ossifying fibroma 9.7 NOTCH1 MDM2
9 ring chromosome 7 9.7 MDM2 CDK4
10 ring chromosome 9.7 MDM2 CDK4
11 mediastinum liposarcoma 9.7 MDM2 CDK4
12 hereditary melanoma 9.7 MDM2 CDK4
13 undifferentiated embryonal sarcoma of the liver 9.7 MDM2 CDK4
14 spindle cell liposarcoma 9.7 MDM2 CDK4
15 pediatric liposarcoma 9.7 MDM2 CDK4
16 infiltrating lipoma 9.7 MDM2 CDK4
17 gastric liposarcoma 9.7 MDM2 CDK4
18 lipoblastoma 9.7 MDM2 CDK4
19 diffuse lipomatosis 9.7 MDM2 CDK4
20 liposarcoma of bone 9.7 MDM2 CDK4
21 malignant inflammatory fibrous histiocytoma 9.7 MDM2 CDK4
22 pancreas sarcoma 9.7 MDM2 CDK4
23 juxtacortical osteosarcoma 9.7 MDM2 CDK4
24 paratesticular lipoma 9.7 MDM2 CDK4
25 lipoma of spermatic cord 9.7 MDM2 CDK4
26 peripheral osteosarcoma 9.7 MDM2 CDK4
27 mixed liposarcoma 9.7 MDM2 CDK4
28 extraosseous osteosarcoma 9.7 MDM2 CDK4
29 retroperitoneal sarcoma 9.7 MDM2 CDK4
30 spindle cell lipoma 9.7 MDM2 CDK4
31 parameningeal embryonal rhabdomyosarcoma 9.6 MDM2 CDK4
32 infiltrating angiolipoma 9.6 MDM2 CDK4
33 myositis ossificans 9.6 MDM2 CDK4
34 cellular myxoid liposarcoma 9.6 MDM2 CDK4
35 dowling-degos disease 9.6 NOTCH1 ADAR
36 familial retinoblastoma 9.6 MDM2 CDK4
37 retroperitoneum carcinoma 9.6 MDM2 CDK4
38 conventional central osteosarcoma 9.6 MDM2 CDK4
39 pleomorphic liposarcoma 9.6 MDM2 CDK4
40 bone osteosarcoma 9.5 MDM2 CDK4
41 embryonal sarcoma 9.4 MDM2 CDK4 AXIN1
42 connective tissue benign neoplasm 9.4 MDM2 CDK4
43 chondrosarcoma 9.3 MDM2 CDK4 BMP2
44 suppression of tumorigenicity 12 9.2 NOTCH1 MDM2 CDK4
45 mantle cell lymphoma 9.1 NOTCH1 MDM2 CDK4
46 osteogenic sarcoma 9.1 MDM2 CDK4 BMP2
47 brain cancer 8.9 NOTCH1 MDM2 CDK4 AXIN1
48 glioblastoma multiforme 8.8 NOTCH1 MDM2 CDK4 AXIN1
49 medulloblastoma 8.7 NOTCH1 MDM2 CDK4 BMP2 AXIN1

Graphical network of the top 20 diseases related to Adult Liposarcoma:



Diseases related to Adult Liposarcoma
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Symptoms & Phenotypes for Adult Liposarcoma

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GenomeRNAi Phenotypes related to Adult Liposarcoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Reduced mammosphere formation GR00396-S 9.02 ADAR CDK4 HNF4A MDM2 NOTCH1

MGI Mouse Phenotypes related to Adult Liposarcoma:

45 (show all 13)
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.13 ADAR AXIN1 BMP2 BTRC CDK4 HNF4A
2 cellular MP:0005384 10.11 ADAR AXIN1 BMP2 BTRC CDK4 HNF4A
3 growth/size/body region MP:0005378 10.03 ADAR AXIN1 BMP2 BTRC CDK4 HNF4A
4 digestive/alimentary MP:0005381 10.02 AXIN1 BMP2 BTRC CDH17 CDK4 MDM2
5 embryo MP:0005380 10 ADAR AXIN1 BMP2 CDK4 HNF4A MDM2
6 hematopoietic system MP:0005397 9.95 ADAR BMP2 BTRC CDH17 CDK4 MDM2
7 immune system MP:0005387 9.91 ADAR BMP2 BTRC CDH17 CDK4 MDM2
8 craniofacial MP:0005382 9.89 AXIN1 BMP2 CDK4 MDM2 NOTCH1
9 nervous system MP:0003631 9.8 ADAR AXIN1 BMP2 CDK4 HNF4A MDM2
10 liver/biliary system MP:0005370 9.72 ADAR CDK4 HNF4A MDM2 NOTCH1
11 normal MP:0002873 9.63 AXIN1 BMP2 CDK4 HNF4A MDM2 NOTCH1
12 renal/urinary system MP:0005367 9.35 AXIN1 CDK4 HNF4A MDM2 NOTCH1
13 skeleton MP:0005390 9.23 ADAR AXIN1 BMP2 BTRC CDK4 HNF4A
Sources

Drugs & Therapeutics for Adult Liposarcoma

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Drugs for Adult Liposarcoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 45)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Doxorubicin Approved, Investigational Phase 3 23214-92-8 31703
2
Ifosfamide Approved Phase 3 3778-73-2 3690
3
Etoposide Approved Phase 3 33419-42-0 36462
4
Lenograstim Approved, Investigational Phase 3 135968-09-1
5 Alkylating Agents Phase 3
6
Liposomal doxorubicin Phase 3 31703
7 Anti-Bacterial Agents Phase 3
8 Antibiotics, Antitubercular Phase 3
9
Isophosphamide mustard Phase 3 0
10 Etoposide phosphate Phase 3
11
Temozolomide Approved, Investigational Phase 2 85622-93-1 5394
12
Rosiglitazone Approved, Investigational Phase 2 122320-73-4 77999
13
Trabectedin Approved, Investigational Phase 2 114899-77-3 108150
14
Sorafenib Approved, Investigational Phase 2 284461-73-0 216239 406563
15
Sunitinib Approved, Investigational Phase 2 557795-19-4, 341031-54-7 5329102
16
Topotecan Approved, Investigational Phase 2 123948-87-8, 119413-54-6 60700
17
Nelfinavir Approved Phase 1, Phase 2 159989-64-7 64143
18
Maleic acid Experimental, Investigational Phase 2 110-17-8, 110-16-7 444972
19 Exatecan Investigational Phase 2 171335-80-1
20 Soblidotin Investigational Phase 2 149606-27-9
21 Hypoglycemic Agents Phase 2
22 Immunosuppressive Agents Phase 2
23 Protein Kinase Inhibitors Phase 2
24 Imatinib Mesylate Phase 1, Phase 2 220127-57-1 123596
25 Angiogenesis Inhibitors Phase 2
26 topoisomerase I inhibitors Phase 2
27
protease inhibitors Phase 1, Phase 2
28 Anti-HIV Agents Phase 1, Phase 2
29 Anti-Infective Agents Phase 1, Phase 2
30 HIV Protease Inhibitors Phase 1, Phase 2
31 Antiviral Agents Phase 1, Phase 2
32 Anti-Retroviral Agents Phase 1, Phase 2
33
Cyclophosphamide Approved, Investigational Phase 1 50-18-0, 6055-19-2 2907
34
Sargramostim Approved, Investigational Phase 1 83869-56-1, 123774-72-1
35
Celecoxib Approved, Investigational Phase 1 169590-42-5 2662
36 Molgramostim Investigational Phase 1 99283-10-0
37 Immunologic Factors Phase 1
38 Antirheumatic Agents Phase 1
39 Vaccines Phase 1
40 Cyclooxygenase 2 Inhibitors Phase 1
41 Analgesics Phase 1
42 Analgesics, Non-Narcotic Phase 1
43 Anti-Inflammatory Agents Phase 1
44 Cyclooxygenase Inhibitors Phase 1
45 Anti-Inflammatory Agents, Non-Steroidal Phase 1

Interventional clinical trials:

(show all 29)
# Name Status NCT ID Phase Drugs
1 A Phase III Randomized Study of Preoperative Radiotherapy Plus Surgery Versus Surgery Alone for Patients With Retroperitoneal Sarcoma (RPS) Unknown status NCT01344018 Phase 3
2 Randomised Trial of Post-Operative Radiotherapy Given to Adult Patients With Extremity Soft Tissue Sarcoma [VORTEX] Completed NCT00423618 Phase 3
3 A Phase III Randomized Study of Preoperative Radiation Plus Surgery Versus Surgery Alone for Patients With Retroperitoneal Sarcomas (RPS) Completed NCT00091351 Phase 3
4 Randomized Phase III Trial of Two Investigational Schedules of Ifosfamide vs. Standard Dose Doxorubicin in Patients With Advanced or Metastatic Soft Tissue Sarcoma Completed NCT00003212 Phase 3 doxorubicin hydrochloride;ifosfamide
5 Randomized Study Comparing Neoadjuvant Chemotherapy Etoposide + Ifosfamide + Adriamycin (EIA) Combined With Regional Hyperthermia (RHT) Versus Neoadjuvant Chemotherapy Alone in the Treatment of High-Risk Soft Tissue Sarcomas in Adults Completed NCT00003052 Phase 3 doxorubicin hydrochloride;etoposide;ifosfamide
6 METASTASECTOMY AND CHEMOTHERAPY FOR LUNG METASTASES FROM SOFT TISSUE SARCOMA: A RANDOMIZED PHASE III STUDY (AN INTERGROUP STUDY WITH THE SCANDINAVIAN SARCOMA GROUP) Completed NCT00002764 Phase 3 doxorubicin hydrochloride;ifosfamide
7 Randomised Trial Of Single Agent Doxorubicin Versus Doxorubicin Plus Ifosfamide In The First Line Treatment Of Advanced Or Metastatic Soft Tissue Sarcoma Completed NCT00061984 Phase 3 doxorubicin hydrochloride;ifosfamide
8 RANDOMISED TRIAL OF ADJUVANT CHEMOTHERAPY WITH HIGH-DOSE DOXORUBICIN, IFOSFAMIDE AND LENOGRASTIM IN HIGH GRADE SOFT TISSUE SARCOMA Completed NCT00002641 Phase 3 doxorubicin hydrochloride;ifosfamide;isolated perfusion
9 Randomized Phase II Study of Brostallicin (PNU-166196A) Versus Doxorubicin as First Line Chemotherapy in Patients With Advanced or Metastatic Soft Tissue Sarcoma Unknown status NCT00410462 Phase 2 brostallicin;doxorubicin hydrochloride
10 Phase II Evaluation of Temodal (Temozolomide, Schering) in Previously Treated Advanced Sarcomas Unknown status NCT00003718 Phase 2 temozolomide
11 Phase II Clinical Trial of Rosiglitazone, a Full-Agonist Ligand for the Peroxisome Proliferator-Activated Receptor Gamma (PPAR), as Differentiation Therapy for Patients With Liposarcoma Completed NCT00004180 Phase 2 rosiglitazone maleate
12 Phase II Study on ET-743 in Advanced Soft Tissue Sarcomas of the Adult Completed NCT00003939 Phase 2 trabectedin
13 Exatecan As Second-Line Treatment In Advanced Adult Soft Tissue Sarcoma: A Phase II - Study Of The EORTC Soft Tissue And Bone Sarcoma Group Completed NCT00041236 Phase 2 exatecan mesylate
14 Phase II Clinical Trial of TROGLITAZONE, a Ligand for the Peroxisome Proliferator-Activated Receptor Gamma (PPAR), as Antineoplastic Differentiation Therapy for Patients With Malignant Liposarcoma Completed NCT00003058 Phase 2 troglitazone
15 Efficacy And Safety Study Of Brostallicin In Patients With Locally Advanced Or Metastatic Soft Tissue Sarcoma Failing One Prior Chemotherapy Treatment Completed NCT00041249 Phase 2 brostallicin
16 A Phase II Study of Intravenous TZT-1027, Administered Weekly Times Two, Every Three Weeks, to Patients With Advanced or Metastatic Soft Tissue Sarcomas (STS) With Prior Exposure to Anthracycline-Based Chemotherapy Completed NCT00064220 Phase 2 soblidotin
17 A Phase II Study Of Perifosine (D-21266) In Patients With Previously Untreated Metastatic Or Locally Advanced Soft Tissue Sarcoma Completed NCT00053794 Phase 2 perifosine
18 Phase II Trial of BAY-9006 (NSC #724772) in Advanced Soft Tissue Sarcomas Completed NCT00217620 Phase 2 sorafenib
19 Multicenter Parallel Phase II Trial of BI 2536 Administered as One Hour IV Infusion Every 3 Weeks in Defined Cohorts of Patients With Various Solid Tumors. A New Drug Screening Program of the EORTC Network of Core Institutions (NOCI) Completed NCT00526149 Phase 2 BI 2536
20 Dose Finding and Phase II Study of STI 571 in Advanced Soft Tissue Sarcoma Completed NCT00006357 Phase 1, Phase 2 imatinib mesylate
21 A Multicenter Phase II Study of Continuous Dosing of Sunitinib (Sutent®, SU11248) in Non-GIST Sarcomas Completed NCT00474994 Phase 2 sunitinib malate
22 A Phase II Study of Pazopanib With Oral Topotecan in Patients With Metastatic and Non-resectable Soft Tissue and Bone Sarcomas Recruiting NCT02357810 Phase 2 Pazopanib Hydrochloride;Oral Topotecan Hydrochloride
23 A Phase I/II Study of Nelfinavir in Liposarcoma Terminated NCT00233948 Phase 1, Phase 2 nelfinavir mesylate
24 A Phase I Study To Determine the Feasibility of Using Autologous NY-ESO-1 Specific CD8+ T Cells For the Treatment of Patients With Advanced Myxoid/ Round Cell Liposarcoma and Synovial Sarcoma. Completed NCT01477021 Phase 1 cyclophosphamide
25 Phase I Study To Determine The Safety Of Caelyx (Doxorubin HCI, Pegylated Liposomal) In Combination With Ifosfamide In Previously Untreated Adult Patients With Advanced And/Or Metastatic Soft Tissues Sarcomas Completed NCT00030784 Phase 1 ifosfamide;pegylated liposomal doxorubicin hydrochloride
26 A Phase I Study of Preoperative Chemoradiation and Intraoperative Radiation Therapy in the Treatment of Retroperitoneal Sarcoma Completed NCT00004123 Phase 1 Doxorubicin hydrochloride (DOX)
27 A Phase I Study Of Vaccination With Telomerase Peptide Plus GM-CSF Completed NCT00069940 Phase 1
28 A Phase I Trial of Postoperative Radiation With Dose-Escalation of A Cox-2 Inhibitor, Celebrexâ„¢ (CELECOXIB) in Patients With Soft Tissue Sarcoma of the Extremity Completed NCT00450736 Phase 1 celecoxib
29 VORTEX-BIOBANK: Prospective Sample Collection for the VORTEX Randomised Radiotherapy Trial in Patients With Extremity Soft Tissue Sarcoma [VORTEX BIOBANK] Unknown status NCT00900211

Search NIH Clinical Center for Adult Liposarcoma

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Genetic Tests for Adult Liposarcoma

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Anatomical Context for Adult Liposarcoma

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MalaCards organs/tissues related to Adult Liposarcoma:

40
Bone, Lung, T Cells
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Publications for Adult Liposarcoma

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Articles related to Adult Liposarcoma:

# Title Authors PMID Year
1
Childhood liposarcoma. Report of a case and review of the literature. 61
6733687 1984
2
Liposarcoma occurring in children. An analysis of 17 cases and review of the literature. 61
6861094 1983
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Variations for Adult Liposarcoma

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Expression for Adult Liposarcoma

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Search GEO for disease gene expression data for Adult Liposarcoma.
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Pathways for Adult Liposarcoma

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Pathways related to Adult Liposarcoma according to GeneCards Suite gene sharing:

(show all 17)
# Super pathways Score Top Affiliating Genes
1
ERK Signaling 63
Show member pathways
 13.34 NOTCH1 MDM2 HNF4A CDK4 CDH17 BMP2
2
PI3K-Akt signaling pathway 36
Show member pathways
 12.66 NOTCH1 MDM2 CDK4 AXIN1
3
Pathways in cancer 36
12.38 NOTCH1 MDM2 CDK4 BMP2 AXIN1
4
Gastric cancer 36
Show member pathways
 12.37 NOTCH1 CDK4 CDH17 AXIN1
5
Human Embryonic Stem Cell Pluripotency 63
Show member pathways
 12.17 HNF4A BMP2 AXIN1
6
Translation Non-genomic (rapid) action of Androgen Receptor 22
Show member pathways
 11.99 MDM2 BMP2 AXIN1
7
Hippo signaling pathway 36
11.83 BTRC BMP2 AXIN1
8
Cellular senescence (KEGG) 36
11.8 MDM2 CDK4 BTRC
9
Glioblastoma Multiforme 63
11.59 MDM2 CDK4 AXIN1
10
WNT Signaling 63
11.42 HNF4A CDK4 CDH17 BTRC AXIN1
11
Presenilin-Mediated Signaling 63
11.41 NOTCH1 CDH17 BTRC AXIN1
12
Transcription_P53 signaling pathway 22
11.39 MDM2 BMP2 AXIN1
13
Integrated Cancer Pathway 1
11.23 MDM2 CDK4
14
Heart Development 1
11.22 NOTCH1 BMP2
15
DNA damage_ATM/ATR regulation of G1/S checkpoint 22
11.18 MDM2 CDK4
16
Oncogene Induced Senescence 65
11.02 MDM2 CDK4
17
Presenilin action in Notch and Wnt signaling 1
10.99 NOTCH1 BTRC AXIN1
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GO Terms for Adult Liposarcoma

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Cellular components related to Adult Liposarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nucleoplasm GO:0005654 9.23 NOTCH1 MYCBP MDM2 HNF4A CDK4 CDH17

Biological processes related to Adult Liposarcoma according to GeneCards Suite gene sharing:

(show all 19)
# Name GO ID Score Top Affiliating Genes
1 heart development GO:0007507 9.72 NOTCH1 MDM2 BMP2
2 positive regulation of transcription, DNA-templated GO:0045893 9.72 NOTCH1 HNF4A BTRC BMP2 AXIN1
3 negative regulation of canonical Wnt signaling pathway GO:0090090 9.7 NOTCH1 BMP2 AXIN1
4 transcription initiation from RNA polymerase II promoter GO:0006367 9.69 NOTCH1 HNF4A CDK4
5 negative regulation of transcription, DNA-templated GO:0045892 9.65 NOTCH1 MDM2 HNF4A BTRC BMP2
6 positive regulation of epithelial to mesenchymal transition GO:0010718 9.58 NOTCH1 BMP2
7 animal organ regeneration GO:0031100 9.58 NOTCH1 CDK4
8 epithelial to mesenchymal transition GO:0001837 9.57 NOTCH1 BMP2
9 positive regulation of cell cycle GO:0045787 9.56 MDM2 CDK4
10 positive regulation of viral genome replication GO:0045070 9.54 NOTCH1 ADAR
11 cellular response to organic cyclic compound GO:0071407 9.54 MDM2 BTRC BMP2
12 negative regulation of cell cycle arrest GO:0071157 9.49 MDM2 CDK4
13 cardiac muscle tissue morphogenesis GO:0055008 9.48 NOTCH1 BMP2
14 cardiac septum morphogenesis GO:0060411 9.46 NOTCH1 MDM2
15 cardiac epithelial to mesenchymal transition GO:0060317 9.43 NOTCH1 BMP2
16 positive regulation of astrocyte differentiation GO:0048711 9.4 NOTCH1 BMP2
17 protein destabilization GO:0031648 9.33 MDM2 BTRC BMP2
18 endocardial cushion morphogenesis GO:0003203 9.13 NOTCH1 MDM2 BMP2
19 atrioventricular valve morphogenesis GO:0003181 8.8 NOTCH1 MDM2 BMP2
Sources

Sources for Adult Liposarcoma

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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