MCID: ADL001
MIFTS: 34

Adult Lymphoma

Categories: Blood diseases, Cancer diseases, Eye diseases, Immune diseases, Rare diseases

Aliases & Classifications for Adult Lymphoma

MalaCards integrated aliases for Adult Lymphoma:

Name: Adult Lymphoma 12 15 71

Classifications:



External Ids:

Disease Ontology 12 DOID:5825
NCIt 49 C7587
UMLS 71 C1332206

Summaries for Adult Lymphoma

MalaCards based summary : Adult Lymphoma is related to nodular lymphocyte predominant hodgkin lymphoma and anaplastic large cell lymphoma. An important gene associated with Adult Lymphoma is CSF3 (Colony Stimulating Factor 3), and among its related pathways/superpathways are NF-kappaB Signaling and B cell receptor signaling pathway (KEGG). The drugs Dexamethasone acetate and Methotrexate have been mentioned in the context of this disorder. Affiliated tissues include b cells, t cells and bone, and related phenotypes are hematopoietic system and immune system

Related Diseases for Adult Lymphoma

Diseases in the Lymphoma family:

Adult Lymphoma Eye Lymphoma

Diseases related to Adult Lymphoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 161)
# Related Disease Score Top Affiliating Genes
1 nodular lymphocyte predominant hodgkin lymphoma 29.9 TNFRSF8 BCL6
2 anaplastic large cell lymphoma 29.7 TNFRSF8 IRF4 ALK
3 adult t-cell leukemia 29.5 TNFRSF8 MYC IRF4
4 gastric lymphoma 29.4 MME IRF4 BCL6
5 lymphoma, hodgkin, classic 29.3 TNFRSF8 IRF4 CSF3 BCL6 ALK
6 intravascular large b-cell lymphoma 28.8 MME CD5 BCL6
7 prolymphocytic leukemia 28.6 MYC CD5 CD19
8 gastrointestinal lymphoma 28.4 TNFRSF8 MME CD5 BCL6
9 lymphoblastic lymphoma 28.2 TNFRSF8 MYC MME CD5 BCL6
10 peripheral t-cell lymphoma 27.3 TNFRSF8 MME CD5 CD19 BCL6 ALK
11 burkitt lymphoma 27.0 TNFRSF8 PRDM1 MYC MME IRF4 CSF3
12 leukemia, acute lymphoblastic 26.8 MME MIR27A IRF4 CSF3 CD5 CD22
13 lymphoma 26.7 TNFRSF8 PRDM1 MYC MME IRF4 CSF3
14 diffuse large b-cell lymphoma 26.2 TNFRSF8 PRDM1 MYC MME IRF4 CSF3
15 b-cell lymphoma 26.1 TNFRSF8 PRDM1 MYC MME IRF4 CD5
16 lymphoma, non-hodgkin, familial 25.2 TNFRSF8 PRDM1 MYC MME MIR27A IRF4
17 primary mediastinal large b-cell lymphoma 10.4 IRF4 BCL6
18 hodgkin's lymphoma, lymphocytic-histiocytic predominance 10.4 TNFRSF8 BCL6
19 primary cutaneous diffuse large b-cell lymphoma, leg type 10.3 MYC IRF4
20 high grade b-cell lymphoma with myc and/ or bcl2 and/or bcl6 rearrangement 10.3 MYC BCL6
21 lymphoma aids related 10.3 MYC BCL6
22 primary cutaneous anaplastic large cell lymphoma 10.3 IRF4 ALK
23 co-trimoxazole allergy 10.3 CSF3 ALK
24 selective igg deficiency disease 10.3 PRDM1 IRF4
25 alk-positive anaplastic large cell lymphoma 10.3 TNFRSF8 ALK
26 breast lipoma 10.3 TNFRSF8 ALK
27 pleural lipoma 10.2 TNFRSF8 ALK
28 lymphomatoid papulosis 10.2 TNFRSF8 ALK
29 ureteral lymphoma 10.2 MME BCL6
30 paranasal sinus lymphoma 10.2 TNFRSF8 CSF3 BCL6
31 ovarian lymphoma 10.2 MME BCL6
32 pediatric systemic lupus erythematosus 10.2 MYC MIR27A
33 hodgkin's lymphoma, lymphocytic depletion 10.2 TNFRSF8 ALK
34 t-cell lymphoma, subcutaneous panniculitis-like 10.2 TNFRSF8 ALK
35 primary cutaneous b-cell lymphoma 10.2 PRDM1 BCL6
36 scabies 10.2 TNFRSF8 CSF3
37 otosalpingitis 10.2 CSF3 CD19
38 lung acinar adenocarcinoma 10.1 MYC ALK
39 lymphosarcoma 10.1 TNFRSF8 CD22 BCL6
40 panniculitis 10.1 TNFRSF8 MYC CSF3
41 alk-negative anaplastic large cell lymphoma 10.1 MYC ALK
42 inflammatory liposarcoma 10.1 MME ALK
43 monoclonal paraproteinemia 10.1 CD22 CD19
44 capillary disease 10.1 CSF3 CD22
45 bladder lateral wall cancer 10.1 MYC MME
46 refractory hematologic cancer 10.1 CD22 CD19
47 refractory hairy cell leukemia 10.1 CD22 CD19
48 cerebral lymphoma 10.1 TNFRSF8 CD19
49 b-cell adult acute lymphocytic leukemia 10.0 CD22 CD19
50 central epithelioid sarcoma 10.0 TNFRSF8 MME

Graphical network of the top 20 diseases related to Adult Lymphoma:



Diseases related to Adult Lymphoma

Symptoms & Phenotypes for Adult Lymphoma

MGI Mouse Phenotypes related to Adult Lymphoma:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.91 BCL6 CD19 CD22 CD5 CSF3 IRF4
2 immune system MP:0005387 9.85 BCL6 CD19 CD22 CD5 CSF3 IRF4
3 integument MP:0010771 9.5 ALK BCL6 CD19 CD5 CSF3 MME
4 neoplasm MP:0002006 9.02 ALK CD19 IRF4 MYC PRDM1

Drugs & Therapeutics for Adult Lymphoma

Drugs for Adult Lymphoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 50)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 4 1177-87-3
2
Methotrexate Approved Phase 4 1959-05-2, 59-05-2 126941
3
Dexamethasone Approved, Investigational, Vet_approved Phase 4 50-02-2 5743
4
Daunorubicin Approved Phase 4 20830-81-3 30323
5
Methylprednisolone hemisuccinate Approved Phase 4 2921-57-5
6
Methylprednisolone Approved, Vet_approved Phase 4 83-43-2 6741
7
Mercaptopurine Approved Phase 4 50-44-2 667490
8
Cladribine Approved, Investigational Phase 4 4291-63-8 20279
9
Cyclophosphamide Approved, Investigational Phase 4 50-18-0, 6055-19-2 2907
10
Doxorubicin Approved, Investigational Phase 4 23214-92-8 31703
11
leucovorin Approved Phase 4 58-05-9 6006 143
12
Thioguanine Approved Phase 4 154-42-7 2723601
13 Prednisolone acetate Approved, Vet_approved Phase 4 52-21-1
14
Prednisolone Approved, Vet_approved Phase 4 50-24-8 5755
15
Vincristine Approved, Investigational Phase 4 2068-78-2, 57-22-7 5978
16
Vindesine Approved, Investigational Phase 4 53643-48-4, 59917-39-4 40839
17
Prednisolone phosphate Approved, Vet_approved Phase 4 302-25-0
18
Cytarabine Approved, Experimental, Investigational Phase 4 147-94-4, 65-46-3 6253
19
Etoposide Approved Phase 4 33419-42-0 36462
20
Folic acid Approved, Nutraceutical, Vet_approved Phase 4 59-30-3 6037
21
Prednisolone hemisuccinate Experimental Phase 4 2920-86-7
22 Antiemetics Phase 4
23 Immunosuppressive Agents Phase 4
24 Alkylating Agents Phase 4
25 Methylprednisolone Acetate Phase 4
26 Vitamin B Complex Phase 4
27 Anti-Infective Agents Phase 4
28 Anti-Bacterial Agents Phase 4
29 Folic Acid Antagonists Phase 4
30 Antibiotics, Antitubercular Phase 4
31 Vitamin B9 Phase 4
32 Dermatologic Agents Phase 4
33 BB 1101 Phase 4
34 Topoisomerase Inhibitors Phase 4
35
asparaginase Phase 4
36 Antiviral Agents Phase 4
37 Hormone Antagonists Phase 4
38
Liposomal doxorubicin Phase 4 31703
39 Folate Phase 4
40 Autonomic Agents Phase 4
41 Anti-Inflammatory Agents Phase 4
42 Gastrointestinal Agents Phase 4
43 Antirheumatic Agents Phase 4
44 Antineoplastic Agents, Hormonal Phase 4
45 Antimetabolites Phase 4
46 glucocorticoids Phase 4
47 Etoposide phosphate Phase 4
48 Hormones Phase 4
49 Antimitotic Agents Phase 4
50 Immunologic Factors Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Multicenter Trial for Treatment Optimization in T-lymphoblastic Lymphoma in Adults and Adolescents Older Than 15 Years (GMALL T-LBL 1/2004) (Amend 1) Completed NCT00199017 Phase 4 Dexamethasone/Prednisolone;Cyclophosphamide;Vincristine;Daunorubicin;Asparaginase;G-CSF;Mercaptopurine;Cytarabine;Methotrexate;VP16;Vindesine;Adriamycin;Thioguanine;HDARAC;Cladribine
2 Radiation Dose Optimization in Diffuse Large B- Cell Lymphoma (DOBL) - A Randomised Phase III Non- Inferiority Trial. Recruiting NCT02964858 Phase 3
3 A Multicenter Pilot Study of Reduced Intensity Allogeneic Stem Cell Transplantation Followed by Adoptive Cellular Immunotherapy With Donor Derived Latent Membrane Protein (LMP) Specific-CTLs in Patients With Epstein-Barr Virus (EBV)Positive Refractory or Recurrent Hodgkin Lymphoma Terminated NCT01636388 Phase 2
4 A Multicenter Pilot Study of Third Party LMP1/2-Specific Cytotoxic T Lymphocytes for Treatment of Patients With Refractory /Relapsed EBV-Associated Lymphoma A Childhood, Adolescent and Young Adult Lymphoma Cell Therapy Consortium (LCTC) Multicenter Clinical Trial Completed NCT02057445 Phase 1 EBV CTL's
5 Pilot Study Evaluating the Use of Proton Radiation for Treatment of Lymphoma Involving the Mediastinum Terminated NCT01751412

Search NIH Clinical Center for Adult Lymphoma

Genetic Tests for Adult Lymphoma

Anatomical Context for Adult Lymphoma

MalaCards organs/tissues related to Adult Lymphoma:

40
B Cells, T Cells, Bone, Breast, Heart, Bone Marrow, Eye

Publications for Adult Lymphoma

Articles related to Adult Lymphoma:

(show top 50) (show all 72)
# Title Authors PMID Year
1
Genetic polymorphisms and vincristine-induced peripheral neuropathy in patients treated with rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone therapy. 61
31993939 2020
2
Serum soluble VSIG4 as a surrogate marker for the diagnosis of lymphoma-associated hemophagocytic lymphohistiocytosis. 61
31960419 2020
3
Targeting chronic NFAT activation with calcineurin inhibitors in diffuse large B-cell lymphoma. 61
31794606 2020
4
Glucocorticoids Induced White Adipose Tissue Hypermetabolism in Cushing's Syndrome. 61
31811068 2019
5
Two Successful Sperm Aspirations in High-Risk Adolescent and Young Adult Lymphoma Patients Before Initiation of Emergent Therapy. 61
31613701 2019
6
Pharmacokinetics of thiotepa in high-dose regimens for autologous hematopoietic stem cell transplant in Japanese patients with pediatric tumors or adult lymphoma. 61
31428821 2019
7
Effect of allogeneic hematopoietic cell transplantation for patients with T-prolymphocytic leukemia: a retrospective study from the Adult Lymphoma Working Group of the Japan Society for hematopoietic cell transplantation. 61
31327025 2019
8
Outcome of patients receiving consolidative autologous peripheral blood stem cell transplantation in the frontline treatment of intravascular large B-cell lymphoma: Adult Lymphoma Working Group of the Japan Society for Hematopoietic Cell Transplantation. 61
30809035 2019
9
Clinical outcomes of hepatitis B or C virus infections in patients with malignant lymphoma receiving autologous stem cell transplantation: on behalf of the Adult Lymphoma Working Group of the Japan Society for Haematopoietic Cell Transplantation (JSHCT). 61
31206602 2019
10
Impact of early rasburicase on incidence of clinical tumor lysis syndrome in lymphoma. 61
31223041 2019
11
Role of 18F-FLT PET/CT in suspected recurrent or residual lymphoma: final results of a pilot prospective trial. 61
31102000 2019
12
Correlations between maximum standardized uptake value measured via 18F-fluorodeoxyglucose positron emission tomography/computed tomography and clinical variables and biochemical indicators in adult lymphoma. 61
31939441 2019
13
Radiation and the heart: systematic review of dosimetry and cardiac endpoints. 61
30360659 2018
14
Proton therapy for adults with mediastinal lymphomas: the International Lymphoma Radiation Oncology Group guidelines. 61
30108066 2018
15
Non-cancer drug consumption during the early trajectory of lymphoma survivorship. 61
29229217 2018
16
The utility of bone marrow sampling in the diagnosis and staging of lymphoma in South Africa. 61
29427399 2018
17
Building a Healthy Body After Cancer: Young Adult Lymphoma Survivors' Perspectives on Exercise After Cancer Treatment. 61
29272188 2018
18
Pharmacotherapeutic Management of Pediatric Lymphoma. 61
29127674 2018
19
Effect of BCLAF1 on HDAC inhibitor LMK-235-mediated apoptosis of diffuse large B cell lymphoma cells and its mechanism. 61
29969367 2018
20
Adolescent and young adult lymphoma: collaborative efforts toward optimizing care and improving outcomes. 61
29296842 2017
21
Impact of Fc gamma-receptor polymorphisms on the response to rituximab treatment in children and adolescents with mature B cell lymphoma/leukemia. 61
27376362 2016
22
Relevance of flow cytometric enumeration of post-thaw leucocytes: influence of temperature during cell staining on viable cell recovery. 61
27037580 2016
23
Hybrid FDG-PET/MR compared to FDG-PET/CT in adult lymphoma patients. 61
27315095 2016
24
Impaired Right Ventricular Function in Long-Term Lymphoma Survivors. 61
27038515 2016
25
Successful management of adult lymphoma-associated intussusception by laparoscopic reduction and appendectomy. 61
27217710 2016
26
Valvular Dysfunction in Lymphoma Survivors Treated With Autologous Stem Cell Transplantation: A National Cross-Sectional Study. 61
26897666 2016
27
Concurrent and Clonally Related Pediatric Follicular Lymphoma and Burkitt Lymphoma in a 5-Year-Old Boy. 61
26732781 2016
28
Reduced-intensity transplantation for lymphomas using haploidentical related donors vs HLA-matched unrelated donors. 61
26670632 2016
29
Lymphoma in Adolescents and Young Adults. 61
27595360 2016
30
Antibody therapies for lymphoma in children. 61
26784573 2016
31
Heart Failure and Asymptomatic Left Ventricular Systolic Dysfunction in Lymphoma Survivors Treated With Autologous Stem-Cell Transplantation: A National Cross-Sectional Study. 61
26169610 2015
32
Revised International Pediatric Non-Hodgkin Lymphoma Staging System. 61
25940716 2015
33
Hepatosplenic T-cell lymphoma: A case series. 61
25450840 2015
34
Outcomes after autologous SCT in lymphoma patients grouped by weight. 61
25665041 2015
35
Liposomal cytarabine in the prophylaxis and treatment of CNS lymphoma: toxicity analysis in a retrospective case series study conducted at Polish Lymphoma Research Group Centers. 61
25716885 2015
36
Changing trends of adult lymphoma in the Kingdom of Saudi Arabia - comparison of data sources. 61
25773852 2015
37
PRDM1/BLIMP1 is commonly inactivated in anaplastic large T-cell lymphoma. 61
24004669 2013
38
Increased IL-6 detection in adult and pediatric lymphoid tissue harboring parvovirus B19. 61
23522566 2013
39
Obesity in adult lymphoma survivors. 61
21888618 2012
40
Management of tumor lysis syndrome with a single fixed dose of rasburicase in Asian lymphoma patients: a case series and literature review. 61
22151984 2011
41
An exploratory model of the relationships between cancer-related trauma outcomes on quality of life in non-Hodgkin lymphoma survivors. 61
21240723 2011
42
Clinicopathologic characteristics and treatment outcome of the addition of rituximab to chemotherapy for CD5-positive in comparison with CD5-negative diffuse large B-cell lymphoma. 61
20231297 2010
43
Ophthalmic disorders in adult lymphoma patients. 61
21180448 2010
44
Nodular, lymphocyte-predominant Hodgkin lymphoma: a long-term study and analysis of transformation to diffuse large B-cell lymphoma in a cohort of 164 patients from the Adult Lymphoma Study Group. 61
20029973 2010
45
Ophthalmic disorders in adult lymphoma patients in Africa. 61
20404992 2009
46
Efficacy and toxicity of 2 schedules of frontline rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone plus bortezomib in patients with B-cell lymphoma: a randomized phase 2 trial from the French Adult Lymphoma Study Group (GELA). 61
19593797 2009
47
Clinical features and prognosis of de novo diffuse large B-cell lymphoma with t(14;18) and 8q24/c-MYC translocations. 61
19151788 2009
48
Clinical significance of 8q24/c-MYC translocation in diffuse large B-cell lymphoma. 61
19038003 2009
49
Adolescent non-Hodgkin lymphoma and Hodgkin lymphoma: state of the science. 61
19087093 2009
50
Utility of PET scans to predict disease relapse in pediatric patients with Hodgkin lymphoma. 61
16514616 2007

Variations for Adult Lymphoma

Expression for Adult Lymphoma

Search GEO for disease gene expression data for Adult Lymphoma.

Pathways for Adult Lymphoma

GO Terms for Adult Lymphoma

Biological processes related to Adult Lymphoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine-mediated signaling pathway GO:0019221 8.92 MYC IRF4 CSF3 BCL6

Sources for Adult Lymphoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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