MCID: ADL001
MIFTS: 38

Adult Lymphoma

Categories: Blood diseases, Cancer diseases, Eye diseases, Immune diseases, Neuronal diseases

Aliases & Classifications for Adult Lymphoma

MalaCards integrated aliases for Adult Lymphoma:

Name: Adult Lymphoma 12 15 74

Classifications:



External Ids:

Disease Ontology 12 DOID:5825
NCIt 51 C7587
UMLS 74 C1332206

Summaries for Adult Lymphoma

MalaCards based summary : Adult Lymphoma is related to diffuse large b-cell lymphoma and lymphoma. An important gene associated with Adult Lymphoma is LSS (Lanosterol Synthase), and among its related pathways/superpathways are PEDF Induced Signaling and PI3K-Akt signaling pathway. The drugs Prednisone and Denileukin diftitox have been mentioned in the context of this disorder. Affiliated tissues include b cells, t cells and lung, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Related Diseases for Adult Lymphoma

Graphical network of the top 20 diseases related to Adult Lymphoma:



Diseases related to Adult Lymphoma

Symptoms & Phenotypes for Adult Lymphoma

GenomeRNAi Phenotypes related to Adult Lymphoma according to GeneCards Suite gene sharing:

27 (show all 16)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-112 9.66 TNFRSF8
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-144 9.66 MYC
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-15 9.66 TNFRSF8
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-160 9.66 MYC
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-171 9.66 PRDM1
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-173 9.66 MYC
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-179 9.66 PRDM1
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-18 9.66 TNFRSF8
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-191 9.66 FCGR2A TNFRSF8
10 Decreased shRNA abundance (Z-score < -2) GR00366-A-26 9.66 MYC
11 Decreased shRNA abundance (Z-score < -2) GR00366-A-34 9.66 FCGR2A
12 Decreased shRNA abundance (Z-score < -2) GR00366-A-58 9.66 TNFRSF8
13 Decreased shRNA abundance (Z-score < -2) GR00366-A-59 9.66 BTK
14 Decreased shRNA abundance (Z-score < -2) GR00366-A-60 9.66 BTK FCGR2A MYC PRDM1 TNFRSF8
15 Decreased shRNA abundance (Z-score < -2) GR00366-A-66 9.66 FCGR2A PRDM1
16 Decreased shRNA abundance (Z-score < -2) GR00366-A-87 9.66 FCGR2A

MGI Mouse Phenotypes related to Adult Lymphoma:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.93 BCLAF1 BTK CABIN1 CD5 CD8B CSF3
2 immune system MP:0005387 9.73 BCLAF1 BTK CABIN1 CD5 CD8B CSF3
3 mortality/aging MP:0010768 9.44 ALK BCLAF1 BTK CABIN1 DNMT3A FCGR2A

Drugs & Therapeutics for Adult Lymphoma

Drugs for Adult Lymphoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 18)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Prednisone Approved, Vet_approved Phase 2 53-03-2 5865
2
Denileukin diftitox Approved, Investigational Phase 2 173146-27-5
3
Vincristine Approved, Investigational Phase 2 2068-78-2, 57-22-7 5978
4
Doxorubicin Approved, Investigational Phase 2 23214-92-8 31703
5
Methotrexate Approved Phase 2 1959-05-2, 59-05-2 126941
6
Vinorelbine Approved, Investigational Phase 2 71486-22-1 44424639 60780
7
Cyclophosphamide Approved, Investigational Phase 2 50-18-0, 6055-19-2 2907
8
Gemcitabine Approved Phase 2 95058-81-4 60750
9
Doxil Approved June 1999 Phase 2 31703
10 Analgesics, Non-Narcotic Phase 2
11 Analgesics Phase 2
12 Peripheral Nervous System Agents Phase 2
13 Interleukin-2 Phase 2
14
Decitabine Approved, Investigational Early Phase 1 2353-33-5 451668
15
Pembrolizumab Approved Early Phase 1 1374853-91-4
16 Antimetabolites, Antineoplastic Early Phase 1
17 Antimetabolites Early Phase 1
18 Antineoplastic Agents, Immunological Early Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Treatment of PTCL With Aggressive Induction Therapy Followed by Autologous SCT Using Denileukin Diftitox (Ontak) Unknown status NCT00632827 Phase 2 REGIMEN;REGIMEN B
2 Allogeneic Stem Cell Transplantation With Adoptive Immunotherapy in Epstein-Barr Virus Positive Recurrent/Refractory Hodgkins Lymphoma Terminated NCT01636388 Phase 2
3 3rd Party LMP1/2-Specific Cytotoxic T Lymphocytes for EBV-Associated Lymphoma Completed NCT02057445 Phase 1 EBV CTL's
4 Study of Gene Modified Donor T Cell Infusion in Patients With Recurrent Disease After Allogeneic Transplant Active, not recruiting NCT02477878 Phase 1 AP1903
5 Pembrolizumab in Combination With Decitabine and Hypofractionated Index Lesion Radiation in Pediatrics and Young Adults Recruiting NCT03445858 Early Phase 1 Pembrolizumab;Decitabine
6 Proton Radiation for Lymphoma Involving Mediastinum Terminated NCT01751412 Not Applicable

Search NIH Clinical Center for Adult Lymphoma

Genetic Tests for Adult Lymphoma

Anatomical Context for Adult Lymphoma

MalaCards organs/tissues related to Adult Lymphoma:

42
B Cells, T Cells, Lung, Colon, Eye, Myeloid

Publications for Adult Lymphoma

Articles related to Adult Lymphoma:

(show all 20)
# Title Authors Year
1
Outcome of patients receiving consolidative autologous peripheral blood stem cell transplantation in the frontline treatment of intravascular large B-cell lymphoma: Adult Lymphoma Working Group of the Japan Society for Hematopoietic Cell Transplantation. ( 30809035 )
2019
2
Building a Healthy Body After Cancer: Young Adult Lymphoma Survivors' Perspectives on Exercise After Cancer Treatment. ( 29272188 )
2018
3
Adolescent and young adult lymphoma: collaborative efforts toward optimizing care and improving outcomes. ( 29296842 )
2017
4
Successful management of adult lymphoma-associated intussusception by laparoscopic reduction and appendectomy. ( 27217710 )
2016
5
Hybrid FDG-PET/MR compared to FDG-PET/CT in adult lymphoma patients. ( 27315095 )
2016
6
Changing trends of adult lymphoma in the Kingdom of Saudi Arabia - comparison of data sources. ( 25773852 )
2015
7
Obesity in adult lymphoma survivors. ( 21888618 )
2012
8
Nodular, lymphocyte-predominant Hodgkin lymphoma: a long-term study and analysis of transformation to diffuse large B-cell lymphoma in a cohort of 164 patients from the Adult Lymphoma Study Group. ( 20029973 )
2010
9
Ophthalmic disorders in adult lymphoma patients. ( 21180448 )
2010
10
Efficacy and toxicity of 2 schedules of frontline rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone plus bortezomib in patients with B-cell lymphoma: a randomized phase 2 trial from the French Adult Lymphoma Study Group (GELA). ( 19593797 )
2009
11
Ophthalmic disorders in adult lymphoma patients in Africa. ( 20404992 )
2009
12
Efficacy and safety of rasburicase (recombinant urate oxidase) for the prevention and treatment of hyperuricemia during induction chemotherapy of aggressive non-Hodgkin's lymphoma: results of the GRAAL1 (Groupe d'Etude des Lymphomes de l'Adulte Trial on Rasburicase Activity in Adult Lymphoma) study. ( 14581437 )
2003
13
Comparison of echocardiography and radionuclide ventriculography in the follow-up of left ventricular systolic function in adult lymphoma patients during doxorubicin therapy. ( 11298849 )
2001
14
Neuroendocrine changes during the evolution of doxorubicin-induced left ventricular dysfunction in adult lymphoma patients. ( 11724646 )
2001
15
CyclOBEAP (cyclophosphamide, vincristine, bleomycin, etoposide, doxorubicin, prednisolone) regimen with granulocyte colony-stimulating factor (G-CSF) for patients with aggressive non-Hodgkin's lymphoma: a pilot study. The Adult Lymphoma Treatment Study Group (ALTSG). ( 11007055 )
2000
16
Beyond cancer: changes, problems and needs expressed by adult lymphoma survivors attending an out-patients clinic. ( 7711981 )
1994
17
Does treatment with haemopoietic growth factors affect the incidence of bacteraemia in adult lymphoma transplant recipients? ( 7687501 )
1993
18
Antibody response to a two-dose influenza vaccine regimen in adult lymphoma patients on chemotherapy. ( 8307050 )
1993
19
Mediastinal large cell lymphoma. An uncommon subset of adult lymphoma curable with combined modality therapy. ( 3167803 )
1988
20
Clinical utility of lymphocyte surface markers combined with the Lukes-Collins histologic classification in adult lymphoma. ( 313510 )
1979

Variations for Adult Lymphoma

Expression for Adult Lymphoma

Search GEO for disease gene expression data for Adult Lymphoma.

Pathways for Adult Lymphoma

GO Terms for Adult Lymphoma

Biological processes related to Adult Lymphoma according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 chromatin organization GO:0006325 9.83 CABIN1 DNMT3A HDAC4 HDAC5
2 response to drug GO:0042493 9.76 DNMT3A HDAC4 HDAC5 MYC
3 response to ethanol GO:0045471 9.65 CSF3 DNMT3A MYC
4 positive regulation of DNA-binding transcription factor activity GO:0051091 9.61 CSF3 HDAC4 HDAC5
5 regulation of protein binding GO:0043393 9.54 HDAC4 HDAC5
6 histone H3 deacetylation GO:0070932 9.51 HDAC4 HDAC5
7 transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 9.5 ALK CD8B FLT1
8 positive regulation of smooth muscle cell migration GO:0014911 9.49 HDAC4 MYC
9 negative regulation of myotube differentiation GO:0010832 9.4 HDAC4 HDAC5
10 regulation of gene expression, epigenetic GO:0040029 9.37 HDAC4 HDAC5
11 chromatin remodeling GO:0006338 9.33 HDAC4 HDAC5 MYC
12 protein deacetylation GO:0006476 9.26 HDAC4 HDAC5
13 positive regulation of response to DNA damage stimulus GO:2001022 8.96 BCLAF1 MYC
14 B cell activation GO:0042113 8.8 BTK HDAC4 HDAC5

Molecular functions related to Adult Lymphoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transcription factor binding GO:0008134 9.73 DNMT3A HDAC4 HDAC5 MYC
2 histone deacetylase binding GO:0042826 9.58 HDAC4 HDAC5 PRDM1
3 RNA polymerase II proximal promoter sequence-specific DNA binding GO:0000978 9.55 DNMT3A HDAC4 HDAC5 MYC PRDM1
4 IgG binding GO:0019864 9.37 FCGR2A FCGR3A
5 NAD-dependent histone deacetylase activity (H3-K14 specific) GO:0032041 9.32 HDAC4 HDAC5
6 protein deacetylase activity GO:0033558 9.26 HDAC4 HDAC5
7 transmembrane signaling receptor activity GO:0004888 8.96 CD5 TNFRSF8
8 repressing transcription factor binding GO:0070491 8.8 HDAC4 HDAC5 MYC

Sources for Adult Lymphoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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