MCID: ADL001
MIFTS: 29

Adult Lymphoma

Categories: Blood diseases, Cancer diseases, Eye diseases, Immune diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Adult Lymphoma

MalaCards integrated aliases for Adult Lymphoma:

Name: Adult Lymphoma 12 15 72

Classifications:



External Ids:

Disease Ontology 12 DOID:5825
NCIt 50 C7587
UMLS 72 C1332206

Summaries for Adult Lymphoma

MalaCards based summary : Adult Lymphoma is related to lymphoma and b-cell lymphoma. An important gene associated with Adult Lymphoma is LSS (Lanosterol Synthase). The drugs Mercaptopurine and Dexamethasone have been mentioned in the context of this disorder. Affiliated tissues include b cells, heart and bone, and related phenotypes are growth/size/body region and mortality/aging

Related Diseases for Adult Lymphoma

Diseases in the Lymphoma family:

Adult Lymphoma Eye Lymphoma

Diseases related to Adult Lymphoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 50)
# Related Disease Score Top Affiliating Genes
1 lymphoma 10.2
2 b-cell lymphoma 9.9
3 diffuse large b-cell lymphoma 9.9
4 lymphoma, hodgkin, classic 9.8
5 burkitt lymphoma 9.7
6 lymphoma, non-hodgkin, familial 9.7
7 anaplastic large cell lymphoma 9.7
8 lymphoblastic lymphoma 9.7
9 intussusception 9.6
10 myelofibrosis 9.6
11 3-methylglutaconic aciduria, type iii 9.6
12 body mass index quantitative trait locus 11 9.6
13 yemenite deaf-blind hypopigmentation syndrome 9.6
14 body mass index quantitative trait locus 9 9.6
15 body mass index quantitative trait locus 8 9.6
16 body mass index quantitative trait locus 4 9.6
17 body mass index quantitative trait locus 10 9.6
18 body mass index quantitative trait locus 7 9.6
19 body mass index quantitative trait locus 12 9.6
20 body mass index quantitative trait locus 14 9.6
21 leukemia, acute lymphoblastic 9.6
22 myelodysplastic syndrome 9.6
23 body mass index quantitative trait locus 18 9.6
24 body mass index quantitative trait locus 19 9.6
25 body mass index quantitative trait locus 20 9.6
26 adult t-cell leukemia 9.6
27 peripheral t-cell lymphoma 9.6
28 follicular lymphoma 9.6
29 cardiac arrest 9.6
30 lymphocytic leukemia 9.6
31 prolymphocytic leukemia 9.6
32 gastric lymphoma 9.6
33 pulmonary edema 9.6
34 facial paralysis 9.6
35 hyperuricemia 9.6
36 constipation 9.6
37 acute t cell leukemia 9.6
38 mediastinal malignant lymphoma 9.6
39 t-cell leukemia 9.6
40 childhood leukemia 9.6
41 gastrointestinal lymphoma 9.6
42 keratoconjunctivitis 9.6
43 exophthalmos 9.6
44 granulocytopenia 9.6
45 leukemia, t-cell, chronic 9.6
46 t-cell prolymphocytic leukemia 9.6
47 hematopoietic stem cell transplantation 9.6
48 nodular lymphocyte predominant hodgkin lymphoma 9.6
49 intravascular large b-cell lymphoma 9.6
50 precursor t-cell acute lymphoblastic leukemia 9.6

Graphical network of the top 20 diseases related to Adult Lymphoma:



Diseases related to Adult Lymphoma

Symptoms & Phenotypes for Adult Lymphoma

MGI Mouse Phenotypes related to Adult Lymphoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 9.35 BCLAF1 HDAC5 IFT172 NPM1 PRDM1
2 mortality/aging MP:0010768 9.1 BCLAF1 HDAC5 IFT172 LSS NPM1 PRDM1

Drugs & Therapeutics for Adult Lymphoma

Drugs for Adult Lymphoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 57)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Mercaptopurine Approved Phase 4 50-44-2 667490
2
Dexamethasone Approved, Investigational, Vet_approved Phase 4 50-02-2 5743
3
Prednisolone phosphate Approved, Vet_approved Phase 4 302-25-0
4
Methotrexate Approved Phase 4 1959-05-2, 59-05-2 126941
5
Methylprednisolone Approved, Vet_approved Phase 4 83-43-2 6741
6
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 4 1177-87-3
7
Methylprednisolone hemisuccinate Approved Phase 4 2921-57-5
8
Vincristine Approved, Investigational Phase 4 57-22-7, 2068-78-2 5978
9
Etoposide Approved Phase 4 33419-42-0 36462
10
Vindesine Approved, Investigational Phase 4 59917-39-4, 53643-48-4 40839
11
Cyclophosphamide Approved, Investigational Phase 4 50-18-0, 6055-19-2 2907
12
leucovorin Approved Phase 4 58-05-9 143 6006
13
Thioguanine Approved Phase 4 154-42-7 2723601
14
Cladribine Approved, Investigational Phase 4 4291-63-8 20279
15
Daunorubicin Approved Phase 4 20830-81-3 30323
16
Prednisolone Approved, Vet_approved Phase 4 50-24-8 5755
17
Cytarabine Approved, Experimental, Investigational Phase 4 147-94-4, 65-46-3 6253
18
Doxorubicin Approved, Investigational Phase 4 23214-92-8 31703
19
Folic acid Approved, Nutraceutical, Vet_approved Phase 4 59-30-3 6037
20
Prednisolone hemisuccinate Experimental Phase 4 2920-86-7
21 Hormone Antagonists Phase 4
22 Antiemetics Phase 4
23 Tubulin Modulators Phase 4
24 Alkylating Agents Phase 4
25 Folic Acid Antagonists Phase 4
26 Gastrointestinal Agents Phase 4
27 Prednisolone acetate Phase 4
28
Liposomal doxorubicin Phase 4 31703
29 Antineoplastic Agents, Phytogenic Phase 4
30 Hormones Phase 4
31 Peripheral Nervous System Agents Phase 4
32 glucocorticoids Phase 4
33 Anti-Inflammatory Agents Phase 4
34 Methylprednisolone Acetate Phase 4
35 Vitamin B9 Phase 4
36 Folate Phase 4
37 Anti-Infective Agents Phase 4
38 Anti-Bacterial Agents Phase 4
39 Immunosuppressive Agents Phase 4
40 Antineoplastic Agents, Hormonal Phase 4
41 Nucleic Acid Synthesis Inhibitors Phase 4
42 Vitamin B Complex Phase 4
43 Antibiotics, Antitubercular Phase 4
44 Topoisomerase Inhibitors Phase 4
45 Dermatologic Agents Phase 4
46 Etoposide phosphate Phase 4
47 Antimitotic Agents Phase 4
48 Antiviral Agents Phase 4
49 Antimetabolites Phase 4
50 BB 1101 Phase 4

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Multicenter Trial for Treatment Optimization in T-lymphoblastic Lymphoma in Adults and Adolescents Older Than 15 Years (GMALL T-LBL 1/2004) (Amend 1) Completed NCT00199017 Phase 4 Dexamethasone/Prednisolone;Cyclophosphamide;Vincristine;Daunorubicin;Asparaginase;G-CSF;Mercaptopurine;Cytarabine;Methotrexate;VP16;Vindesine;Adriamycin;Thioguanine;HDARAC;Cladribine
2 Radiation Dose Optimization in Diffuse Large B- Cell Lymphoma (DOBL) - A Randomised Phase III Non- Inferiority Trial. Recruiting NCT02964858 Phase 3
3 A Multicenter Pilot Study of Reduced Intensity Allogeneic Stem Cell Transplantation Followed by Adoptive Cellular Immunotherapy With Donor Derived Latent Membrane Protein (LMP) Specific-CTLs in Patients With Epstein-Barr Virus (EBV)Positive Refractory or Recurrent Hodgkin Lymphoma Terminated NCT01636388 Phase 2
4 A Multicenter Pilot Study of Third Party LMP1/2-Specific Cytotoxic T Lymphocytes for Treatment of Patients With Refractory /Relapsed EBV-Associated Lymphoma A Childhood, Adolescent and Young Adult Lymphoma Cell Therapy Consortium (LCTC) Multicenter Clinical Trial Completed NCT02057445 Phase 1 EBV CTL's
5 Pilot Study Evaluating the Use of Proton Radiation for Treatment of Lymphoma Involving the Mediastinum Terminated NCT01751412

Search NIH Clinical Center for Adult Lymphoma

Genetic Tests for Adult Lymphoma

Anatomical Context for Adult Lymphoma

MalaCards organs/tissues related to Adult Lymphoma:

41
B Cells, Heart, Bone, T Cells, Bone Marrow, Thymus

Publications for Adult Lymphoma

Articles related to Adult Lymphoma:

(show top 50) (show all 66)
# Title Authors PMID Year
1
Effect of allogeneic hematopoietic cell transplantation for patients with T-prolymphocytic leukemia: a retrospective study from the Adult Lymphoma Working Group of the Japan Society for hematopoietic cell transplantation. 38
31327025 2019
2
Pharmacokinetics of thiotepa in high-dose regimens for autologous hematopoietic stem cell transplant in Japanese patients with pediatric tumors or adult lymphoma. 38
31428821 2019
3
Role of 18F-FLT PET/CT in suspected recurrent or residual lymphoma: final results of a pilot prospective trial. 38
31102000 2019
4
Impact of early rasburicase on incidence of clinical tumor lysis syndrome in lymphoma. 38
31223041 2019
5
Clinical outcomes of hepatitis B or C virus infections in patients with malignant lymphoma receiving autologous stem cell transplantation: on behalf of the Adult Lymphoma Working Group of the Japan Society for Haematopoietic Cell Transplantation (JSHCT). 38
31206602 2019
6
Outcome of patients receiving consolidative autologous peripheral blood stem cell transplantation in the frontline treatment of intravascular large B-cell lymphoma: Adult Lymphoma Working Group of the Japan Society for Hematopoietic Cell Transplantation. 38
30809035 2019
7
Radiation and the heart: systematic review of dosimetry and cardiac endpoints. 38
30360659 2018
8
Proton therapy for adults with mediastinal lymphomas: the International Lymphoma Radiation Oncology Group guidelines. 38
30108066 2018
9
Non-cancer drug consumption during the early trajectory of lymphoma survivorship. 38
29229217 2018
10
The utility of bone marrow sampling in the diagnosis and staging of lymphoma in South Africa. 38
29427399 2018
11
Building a Healthy Body After Cancer: Young Adult Lymphoma Survivors' Perspectives on Exercise After Cancer Treatment. 38
29272188 2018
12
Pharmacotherapeutic Management of Pediatric Lymphoma. 38
29127674 2018
13
Effect of BCLAF1 on HDAC inhibitor LMK-235-mediated apoptosis of diffuse large B cell lymphoma cells and its mechanism. 38
29969367 2018
14
Adolescent and young adult lymphoma: collaborative efforts toward optimizing care and improving outcomes. 38
29296842 2017
15
Impact of Fc gamma-receptor polymorphisms on the response to rituximab treatment in children and adolescents with mature B cell lymphoma/leukemia. 38
27376362 2016
16
Relevance of flow cytometric enumeration of post-thaw leucocytes: influence of temperature during cell staining on viable cell recovery. 38
27037580 2016
17
Hybrid FDG-PET/MR compared to FDG-PET/CT in adult lymphoma patients. 38
27315095 2016
18
Impaired Right Ventricular Function in Long-Term Lymphoma Survivors. 38
27038515 2016
19
Successful management of adult lymphoma-associated intussusception by laparoscopic reduction and appendectomy. 38
27217710 2016
20
Valvular Dysfunction in Lymphoma Survivors Treated With Autologous Stem Cell Transplantation: A National Cross-Sectional Study. 38
26897666 2016
21
Concurrent and Clonally Related Pediatric Follicular Lymphoma and Burkitt Lymphoma in a 5-Year-Old Boy. 38
26732781 2016
22
Reduced-intensity transplantation for lymphomas using haploidentical related donors vs HLA-matched unrelated donors. 38
26670632 2016
23
Antibody therapies for lymphoma in children. 38
26784573 2016
24
Lymphoma in Adolescents and Young Adults. 38
27595360 2016
25
Heart Failure and Asymptomatic Left Ventricular Systolic Dysfunction in Lymphoma Survivors Treated With Autologous Stem-Cell Transplantation: A National Cross-Sectional Study. 38
26169610 2015
26
Revised International Pediatric Non-Hodgkin Lymphoma Staging System. 38
25940716 2015
27
Hepatosplenic T-cell lymphoma: A case series. 38
25450840 2015
28
Outcomes after autologous SCT in lymphoma patients grouped by weight. 38
25665041 2015
29
Liposomal cytarabine in the prophylaxis and treatment of CNS lymphoma: toxicity analysis in a retrospective case series study conducted at Polish Lymphoma Research Group Centers. 38
25716885 2015
30
Changing trends of adult lymphoma in the Kingdom of Saudi Arabia - comparison of data sources. 38
25773852 2015
31
PRDM1/BLIMP1 is commonly inactivated in anaplastic large T-cell lymphoma. 38
24004669 2013
32
Increased IL-6 detection in adult and pediatric lymphoid tissue harboring parvovirus B19. 38
23522566 2013
33
Obesity in adult lymphoma survivors. 38
21888618 2012
34
Management of tumor lysis syndrome with a single fixed dose of rasburicase in Asian lymphoma patients: a case series and literature review. 38
22151984 2011
35
An exploratory model of the relationships between cancer-related trauma outcomes on quality of life in non-Hodgkin lymphoma survivors. 38
21240723 2011
36
Ophthalmic disorders in adult lymphoma patients. 38
21180448 2010
37
Clinicopathologic characteristics and treatment outcome of the addition of rituximab to chemotherapy for CD5-positive in comparison with CD5-negative diffuse large B-cell lymphoma. 38
20231297 2010
38
Nodular, lymphocyte-predominant Hodgkin lymphoma: a long-term study and analysis of transformation to diffuse large B-cell lymphoma in a cohort of 164 patients from the Adult Lymphoma Study Group. 38
20029973 2010
39
Ophthalmic disorders in adult lymphoma patients in Africa. 38
20404992 2009
40
Efficacy and toxicity of 2 schedules of frontline rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone plus bortezomib in patients with B-cell lymphoma: a randomized phase 2 trial from the French Adult Lymphoma Study Group (GELA). 38
19593797 2009
41
Clinical features and prognosis of de novo diffuse large B-cell lymphoma with t(14;18) and 8q24/c-MYC translocations. 38
19151788 2009
42
Clinical significance of 8q24/c-MYC translocation in diffuse large B-cell lymphoma. 38
19038003 2009
43
Adolescent non-Hodgkin lymphoma and Hodgkin lymphoma: state of the science. 38
19087093 2009
44
Utility of PET scans to predict disease relapse in pediatric patients with Hodgkin lymphoma. 38
16514616 2007
45
Follicular lymphoma-like B cells in healthy individuals: a novel intermediate step in early lymphomagenesis. 38
17043145 2006
46
Staging in childhood lymphoma: differences between FDG-PET and CT. 38
15711722 2005
47
Loss to follow-up of patients with malignant lymphoma. 38
15115474 2004
48
Efficacy and safety of rasburicase (recombinant urate oxidase) for the prevention and treatment of hyperuricemia during induction chemotherapy of aggressive non-Hodgkin's lymphoma: results of the GRAAL1 (Groupe d'Etude des Lymphomes de l'Adulte Trial on Rasburicase Activity in Adult Lymphoma) study. 38
14581437 2003
49
Concomitant impairment of left ventricular systolic and diastolic function during doxorubicin therapy: a prospective radionuclide ventriculographic and echocardiographic study. 38
12685836 2002
50
Neuroendocrine changes during the evolution of doxorubicin-induced left ventricular dysfunction in adult lymphoma patients. 38
11724646 2001

Variations for Adult Lymphoma

Expression for Adult Lymphoma

Search GEO for disease gene expression data for Adult Lymphoma.

Pathways for Adult Lymphoma

GO Terms for Adult Lymphoma

Biological processes related to Adult Lymphoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 chromatin remodeling GO:0006338 8.62 NPM1 HDAC5

Molecular functions related to Adult Lymphoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 histone deacetylase binding GO:0042826 8.62 PRDM1 HDAC5

Sources for Adult Lymphoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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