MCID: ADL001
MIFTS: 38

Adult Lymphoma

Categories: Blood diseases, Cancer diseases, Eye diseases, Immune diseases, Neuronal diseases

Aliases & Classifications for Adult Lymphoma

MalaCards integrated aliases for Adult Lymphoma:

Name: Adult Lymphoma 12 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:5825
NCIt 50 C7587
UMLS 73 C1332206

Summaries for Adult Lymphoma

MalaCards based summary : Adult Lymphoma is related to b-cell lymphomas and diffuse large b-cell lymphoma. An important gene associated with Adult Lymphoma is BCLAF1 (BCL2 Associated Transcription Factor 1), and among its related pathways/superpathways are NF-kappaB Signaling and Neural Crest Differentiation. The drugs Doxorubicin and Gemcitabine have been mentioned in the context of this disorder. Affiliated tissues include b cells, eye and lung, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Related Diseases for Adult Lymphoma

Diseases in the Lymphoma family:

Adult Lymphoma Eye Lymphoma

Diseases related to Adult Lymphoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 46)
# Related Disease Score Top Affiliating Genes
1 b-cell lymphomas 29.4 CD5 MYC PRDM1 TNFRSF8
2 diffuse large b-cell lymphoma 29.2 CD5 MYC PRDM1 TNFRSF8
3 lymphoma, hodgkin, classic 29.2 ALK CD5 SMUG1
4 middle ear carcinoma 10.2 CSF3 SMUG1
5 ovarian squamous cell carcinoma 10.2 CSF3 SMUG1
6 bone lymphoma 10.2 IFT172 SMUG1
7 lymphoma 10.2
8 prostate lymphoma 10.2 CD5 SMUG1
9 breast lymphoma 10.2 CD5 SMUG1
10 mediastinal cancer 10.1 CD5 SMUG1
11 pericardial tuberculosis 10.1 CABIN1 SMUG1
12 t-cell adult acute lymphocytic leukemia 10.1 CD2 CD5
13 sternum cancer 10.1 SMUG1 TNFRSF8
14 b cell prolymphocytic leukemia 10.1 CD5 MYC
15 malignant epithelioid hemangioendothelioma 10.1 MYC SMUG1
16 granulomatous myositis 10.1 SMUG1 TNFRSF8
17 epidural neoplasm 10.1 CD5 TNFRSF8
18 plasmablastic lymphoma 10.1 MYC PRDM1
19 thymus lipoma 10.1 CD5 TNFRSF8
20 granulomatous disease, chronic, autosomal recessive, cytochrome b-positive, type ii 10.0 PRDM1 TNFRSF8
21 autoimmune lymphoproliferative syndrome, type v 10.0 ALK CD5
22 reticulum cell sarcoma 10.0 CD2 TNFRSF8
23 poliomyelitis 10.0 FCGR2A FCGR3A
24 immune system organ benign neoplasm 10.0 CD5 TNFRSF8
25 hodgkin's lymphoma, lymphocytic depletion 10.0 ALK TNFRSF8
26 lymphatic system disease 10.0 CD5 SMUG1 TNFRSF8
27 richter's syndrome 10.0 CD5 MYC
28 primary thrombocytopenia 10.0 FCGR2A FCGR3A
29 lemierre's syndrome 9.9 ALK SMUG1
30 ecthyma 9.9 ALK CSF3 TNFRSF8
31 alk-negative anaplastic large cell lymphoma 9.9 ALK MYC
32 myeloma, multiple 9.9 CSF3 MYC PRDM1 SMUG1
33 colon lymphoma 9.9 ALK CD5 TNFRSF8
34 peripheral t-cell lymphoma 9.9 ALK CD5 TNFRSF8
35 pediatric lymphoma 9.9 ALK SMUG1 TNFRSF8
36 respiratory system cancer 9.9 ALK MYC SMUG1
37 lung lymphoma 9.8 ALK CD5 SMUG1 TNFRSF8
38 leukocyte disease 9.5 CD2 CD5 CSF3 MYC SMUG1 TNFRSF8
39 burkitt lymphoma 9.5
40 intussusception 9.5
41 hyperuricemia 9.5
42 influenza 9.5
43 nodular lymphocyte predominant hodgkin lymphoma 9.5
44 hematologic cancer 9.5 ALK CD2 CD5 CSF3 MYC TNFRSF8
45 lymphatic system cancer 9.4 ALK CD2 CD5 MYC SMUG1 TNFRSF8
46 lymphoma, non-hodgkin, familial 9.4 ALK CD5 CSF3 FCGR3A MYC SMUG1

Graphical network of the top 20 diseases related to Adult Lymphoma:



Diseases related to Adult Lymphoma

Symptoms & Phenotypes for Adult Lymphoma

GenomeRNAi Phenotypes related to Adult Lymphoma according to GeneCards Suite gene sharing:

26 (show all 15)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-112 9.62 TNFRSF8
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-144 9.62 MYC
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-15 9.62 TNFRSF8
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-160 9.62 MYC
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-171 9.62 PRDM1
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-173 9.62 MYC
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-179 9.62 PRDM1
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-18 9.62 TNFRSF8
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-191 9.62 FCGR2A TNFRSF8
10 Decreased shRNA abundance (Z-score < -2) GR00366-A-26 9.62 MYC
11 Decreased shRNA abundance (Z-score < -2) GR00366-A-34 9.62 FCGR2A
12 Decreased shRNA abundance (Z-score < -2) GR00366-A-58 9.62 TNFRSF8
13 Decreased shRNA abundance (Z-score < -2) GR00366-A-60 9.62 FCGR2A MYC PRDM1 TNFRSF8
14 Decreased shRNA abundance (Z-score < -2) GR00366-A-66 9.62 FCGR2A PRDM1
15 Decreased shRNA abundance (Z-score < -2) GR00366-A-87 9.62 FCGR2A

MGI Mouse Phenotypes related to Adult Lymphoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.61 BCLAF1 CABIN1 CD5 CD8B CSF3 FCGR2A
2 immune system MP:0005387 9.28 BCLAF1 CABIN1 CD5 CD8B CSF3 FCGR2A

Drugs & Therapeutics for Adult Lymphoma

Drugs for Adult Lymphoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 18)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Doxorubicin Approved, Investigational Phase 2 23214-92-8 31703
2
Gemcitabine Approved Phase 2 95058-81-4 60750
3
Cyclophosphamide Approved, Investigational Phase 2 6055-19-2, 50-18-0 2907
4
Denileukin diftitox Approved, Investigational Phase 2 173146-27-5
5
Methotrexate Approved Phase 2 59-05-2, 1959-05-2 126941
6
Prednisone Approved, Vet_approved Phase 2 53-03-2 5865
7
Vincristine Approved, Investigational Phase 2 57-22-7, 2068-78-2 5978
8
Vinorelbine Approved, Investigational Phase 2 71486-22-1 60780 44424639
9
Doxil Approved June 1999 Phase 2 31703
10 Analgesics, Non-Narcotic Phase 2
11 Peripheral Nervous System Agents Phase 2
12 Analgesics Phase 2
13 Interleukin-2 Phase 2
14
Decitabine Approved, Investigational Early Phase 1 2353-33-5 451668
15
Azacitidine Approved, Investigational Early Phase 1 320-67-2 9444
16
Pembrolizumab Approved Early Phase 1 1374853-91-4
17 Antimetabolites, Antineoplastic Early Phase 1
18 Antimetabolites Early Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Treatment of PTCL With Aggressive Induction Therapy Followed by Autologous SCT Using Denileukin Diftitox (Ontak) Unknown status NCT00632827 Phase 2 REGIMEN;REGIMEN B
2 Allogeneic Stem Cell Transplantation With Adoptive Immunotherapy in Epstein-Barr Virus Positive Recurrent/Refractory Hodgkins Lymphoma Terminated NCT01636388 Phase 2
3 3rd Party LMP1/2-Specific Cytotoxic T Lymphocytes for EBV-Associated Lymphoma Completed NCT02057445 Phase 1 EBV CTL's
4 Study of Gene Modified Donor T Cell Infusion in Patients With Recurrent Disease After Allogeneic Transplant Active, not recruiting NCT02477878 Phase 1 AP1903
5 Pembrolizumab in Combination With Decitabine and Hypofractionated Index Lesion Radiation in Pediatrics and Young Adults Recruiting NCT03445858 Early Phase 1 Pembrolizumab;Decitabine
6 Proton Radiation for Lymphoma Involving Mediastinum Terminated NCT01751412 Not Applicable

Search NIH Clinical Center for Adult Lymphoma

Genetic Tests for Adult Lymphoma

Anatomical Context for Adult Lymphoma

MalaCards organs/tissues related to Adult Lymphoma:

41
B Cells, Eye, Lung, Bone, Colon, Breast, Thymus

Publications for Adult Lymphoma

Articles related to Adult Lymphoma:

(show all 19)
# Title Authors Year
1
Adolescent and young adult lymphoma: collaborative efforts toward optimizing care and improving outcomes. ( 29296842 )
2017
2
Building a Healthy Body After Cancer: Young Adult Lymphoma Survivors' Perspectives on Exercise After Cancer Treatment. ( 29272188 )
2017
3
Hybrid FDG-PET/MR compared to FDG-PET/CT in adult lymphoma patients. ( 27315095 )
2016
4
Successful management of adult lymphoma-associated intussusception by laparoscopic reduction and appendectomy. ( 27217710 )
2016
5
Changing trends of adult lymphoma in the kingdom of saudi arabia - comparison of data sources. ( 25773852 )
2015
6
Obesity in adult lymphoma survivors. ( 21888618 )
2012
7
Nodular, lymphocyte-predominant Hodgkin lymphoma: a long-term study and analysis of transformation to diffuse large B-cell lymphoma in a cohort of 164 patients from the Adult Lymphoma Study Group. ( 20029973 )
2010
8
Ophthalmic disorders in adult lymphoma patients. ( 21180448 )
2010
9
Efficacy and toxicity of 2 schedules of frontline rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone plus bortezomib in patients with B-cell lymphoma: a randomized phase 2 trial from the French Adult Lymphoma Study Group (GELA). ( 19593797 )
2009
10
Ophthalmic disorders in adult lymphoma patients in Africa. ( 20404992 )
2009
11
Efficacy and safety of rasburicase (recombinant urate oxidase) for the prevention and treatment of hyperuricemia during induction chemotherapy of aggressive non-Hodgkin's lymphoma: results of the GRAAL1 (Groupe d'Etude des Lymphomes de l'Adulte Trial on Rasburicase Activity in Adult Lymphoma) study. ( 14581437 )
2003
12
Comparison of echocardiography and radionuclide ventriculography in the follow-up of left ventricular systolic function in adult lymphoma patients during doxorubicin therapy. ( 11298849 )
2001
13
Neuroendocrine changes during the evolution of doxorubicin-induced left ventricular dysfunction in adult lymphoma patients. ( 11724646 )
2001
14
CyclOBEAP (cyclophosphamide, vincristine, bleomycin, etoposide, doxorubicin, prednisolone) regimen with granulocyte colony-stimulating factor (G-CSF) for patients with aggressive non-Hodgkin's lymphoma: a pilot study. The Adult Lymphoma Treatment Study Group (ALTSG). ( 11007055 )
2000
15
Beyond cancer: changes, problems and needs expressed by adult lymphoma survivors attending an out-patients clinic. ( 7711981 )
1994
16
Does treatment with haemopoietic growth factors affect the incidence of bacteraemia in adult lymphoma transplant recipients? ( 7687501 )
1993
17
Antibody response to a two-dose influenza vaccine regimen in adult lymphoma patients on chemotherapy. ( 8307050 )
1993
18
Mediastinal large cell lymphoma. An uncommon subset of adult lymphoma curable with combined modality therapy. ( 3167803 )
1988
19
Clinical utility of lymphocyte surface markers combined with the Lukes-Collins histologic classification in adult lymphoma. ( 313510 )
1979

Variations for Adult Lymphoma

Expression for Adult Lymphoma

Search GEO for disease gene expression data for Adult Lymphoma.

Pathways for Adult Lymphoma

Pathways related to Adult Lymphoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 12.14 CABIN1 CD2 PRDM1 TNFRSF8
2 11.44 HDAC4 HDAC5 MYC
3 11.32 CD2 CD5 CSF3 FCGR2A
4 11.06 CD5 PRDM1 TNFRSF8
5 10.91 CD2 CD5 CD8B CSF3

GO Terms for Adult Lymphoma

Biological processes related to Adult Lymphoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 B cell activation GO:0042113 9.48 HDAC4 HDAC5
2 regulation of protein binding GO:0043393 9.46 HDAC4 HDAC5
3 histone H3 deacetylation GO:0070932 9.43 HDAC4 HDAC5
4 positive regulation of DNA-binding transcription factor activity GO:0051091 9.43 CSF3 HDAC4 HDAC5
5 positive regulation of smooth muscle cell migration GO:0014911 9.4 HDAC4 MYC
6 negative regulation of myotube differentiation GO:0010832 9.37 HDAC4 HDAC5
7 regulation of gene expression, epigenetic GO:0040029 9.32 HDAC4 HDAC5
8 protein deacetylation GO:0006476 9.16 HDAC4 HDAC5
9 positive regulation of response to DNA damage stimulus GO:2001022 8.96 BCLAF1 MYC
10 chromatin remodeling GO:0006338 8.8 HDAC4 HDAC5 MYC

Molecular functions related to Adult Lymphoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 histone deacetylase binding GO:0042826 9.5 HDAC4 HDAC5 PRDM1
2 IgG binding GO:0019864 9.26 FCGR2A FCGR3A
3 NAD-dependent histone deacetylase activity (H3-K14 specific) GO:0032041 9.16 HDAC4 HDAC5
4 protein deacetylase activity GO:0033558 8.96 HDAC4 HDAC5
5 repressing transcription factor binding GO:0070491 8.8 HDAC4 HDAC5 MYC

Sources for Adult Lymphoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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