MCID: ADL042
MIFTS: 14

Adult Malignant Schwannoma

Categories: Cancer diseases, Neuronal diseases

Aliases & Classifications for Adult Malignant Schwannoma

MalaCards integrated aliases for Adult Malignant Schwannoma:

Name: Adult Malignant Schwannoma 12 15
Adult Neurofibrosarcoma 72
Adult Mpnst 12

Classifications:



External Ids:

Disease Ontology 12 DOID:8369
NCIt 50 C7814
UMLS 72 C0278622

Summaries for Adult Malignant Schwannoma

MalaCards based summary : Adult Malignant Schwannoma, is also known as adult neurofibrosarcoma. An important gene associated with Adult Malignant Schwannoma is NF1 (Neurofibromin 1). The drugs Ifosfamide and Mechlorethamine have been mentioned in the context of this disorder. Affiliated tissues include lung and bone.

Related Diseases for Adult Malignant Schwannoma

Symptoms & Phenotypes for Adult Malignant Schwannoma

Drugs & Therapeutics for Adult Malignant Schwannoma

Drugs for Adult Malignant Schwannoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 37)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ifosfamide Approved Phase 3 3778-73-2 3690
2
Mechlorethamine Approved, Investigational Phase 3 51-75-2 4033
3
Etoposide Approved Phase 3 33419-42-0 36462
4
Lenograstim Approved, Investigational Phase 3 135968-09-1
5
Trabectedin Approved, Investigational Phase 2, Phase 3 114899-77-3 108150
6
Doxorubicin Approved, Investigational Phase 2, Phase 3 23214-92-8 31703
7 Antineoplastic Agents, Phytogenic Phase 3
8
Isophosphamide mustard Phase 3 0
9 Etoposide phosphate Phase 3
10 Alkylating Agents Phase 2, Phase 3
11 Antineoplastic Agents, Alkylating Phase 2, Phase 3
12 Topoisomerase Inhibitors Phase 2, Phase 3
13
Liposomal doxorubicin Phase 2, Phase 3 31703
14 Anti-Bacterial Agents Phase 2, Phase 3
15 Antibiotics, Antitubercular Phase 2, Phase 3
16
Temozolomide Approved, Investigational Phase 2 85622-93-1 5394
17
Sunitinib Approved, Investigational Phase 2 557795-19-4, 341031-54-7 5329102
18 Exatecan Investigational Phase 2 171335-80-1
19
Camptothecin Experimental Phase 2 7689-03-4
20 topoisomerase I inhibitors Phase 2
21
Erlotinib Hydrochloride Phase 2 183319-69-9 176871
22 Protein Kinase Inhibitors Phase 2
23 Angiogenesis Inhibitors Phase 2
24 Angiogenesis Modulating Agents Phase 2
25 Immunosuppressive Agents Phase 2
26 Imatinib Mesylate Phase 1, Phase 2 220127-57-1 123596
27 Immunologic Factors Phase 2
28 Adjuvants, Immunologic Phase 2
29
Celecoxib Approved, Investigational Phase 1 169590-42-5 2662
30 Analgesics Phase 1
31 Anti-Inflammatory Agents Phase 1
32 Analgesics, Non-Narcotic Phase 1
33 Cyclooxygenase Inhibitors Phase 1
34 Cyclooxygenase 2 Inhibitors Phase 1
35 Peripheral Nervous System Agents Phase 1
36 Anti-Inflammatory Agents, Non-Steroidal Phase 1
37 Antirheumatic Agents Phase 1

Interventional clinical trials:

(show all 23)
# Name Status NCT ID Phase Drugs
1 Randomised Trial of Post-Operative Radiotherapy Given to Adult Patients With Extremity Soft Tissue Sarcoma [VORTEX] Completed NCT00423618 Phase 3
2 A Phase III Randomized Study of Preoperative Radiation Plus Surgery Versus Surgery Alone for Patients With Retroperitoneal Sarcomas (RPS) Completed NCT00091351 Phase 3
3 Randomised Trial Of Single Agent Doxorubicin Versus Doxorubicin Plus Ifosfamide In The First Line Treatment Of Advanced Or Metastatic Soft Tissue Sarcoma Completed NCT00061984 Phase 3 doxorubicin hydrochloride;ifosfamide
4 Randomized Phase III Trial of Two Investigational Schedules of Ifosfamide vs. Standard Dose Doxorubicin in Patients With Advanced or Metastatic Soft Tissue Sarcoma Completed NCT00003212 Phase 3 doxorubicin hydrochloride;ifosfamide
5 Randomized Study Comparing Neoadjuvant Chemotherapy Etoposide + Ifosfamide + Adriamycin (EIA) Combined With Regional Hyperthermia (RHT) Versus Neoadjuvant Chemotherapy Alone in the Treatment of High-Risk Soft Tissue Sarcomas in Adults Completed NCT00003052 Phase 3 doxorubicin hydrochloride;etoposide;ifosfamide
6 METASTASECTOMY AND CHEMOTHERAPY FOR LUNG METASTASES FROM SOFT TISSUE SARCOMA: A RANDOMIZED PHASE III STUDY (AN INTERGROUP STUDY WITH THE SCANDINAVIAN SARCOMA GROUP) Completed NCT00002764 Phase 3 doxorubicin hydrochloride;ifosfamide
7 RANDOMISED TRIAL OF ADJUVANT CHEMOTHERAPY WITH HIGH-DOSE DOXORUBICIN, IFOSFAMIDE AND LENOGRASTIM IN HIGH GRADE SOFT TISSUE SARCOMA Completed NCT00002641 Phase 3 doxorubicin hydrochloride;ifosfamide;isolated perfusion
8 TRUSTS: A Phase IIB/III Multicenter Study Comparing the Efficacy of TRabectedin Administered as a 3-Hour or 24-Hour Infusion to Doxorubicin in Patients With Advanced or Metastatic Untreated Soft Tissue Sarcoma Terminated NCT01189253 Phase 2, Phase 3 doxorubicin hydrochloride;trabectedin
9 Randomized Phase II Study of Brostallicin (PNU-166196A) Versus Doxorubicin as First Line Chemotherapy in Patients With Advanced or Metastatic Soft Tissue Sarcoma Unknown status NCT00410462 Phase 2 brostallicin;doxorubicin hydrochloride
10 Phase II Evaluation of Temodal (Temozolomide, Schering) in Previously Treated Advanced Sarcomas Unknown status NCT00003718 Phase 2 temozolomide
11 Phase II Study on ET-743 in Advanced Soft Tissue Sarcomas of the Adult Completed NCT00003939 Phase 2 trabectedin
12 Exatecan As Second-Line Treatment In Advanced Adult Soft Tissue Sarcoma: A Phase II - Study Of The EORTC Soft Tissue And Bone Sarcoma Group Completed NCT00041236 Phase 2 exatecan mesylate
13 U.S./Canada Sarcoma Intergroup Study of OSI-774 in Malignant Peripheral Nerve Sheath Tumors, Phase II Completed NCT00068367 Phase 2 erlotinib hydrochloride
14 A Phase II Study Of Perifosine (D-21266) In Patients With Previously Untreated Metastatic Or Locally Advanced Soft Tissue Sarcoma Completed NCT00053794 Phase 2 perifosine
15 Efficacy And Safety Study Of Brostallicin In Patients With Locally Advanced Or Metastatic Soft Tissue Sarcoma Failing One Prior Chemotherapy Treatment Completed NCT00041249 Phase 2 brostallicin
16 A Multicenter Phase II Study of Continuous Dosing of Sunitinib (Sutent®, SU11248) in Non-GIST Sarcomas Completed NCT00474994 Phase 2 sunitinib malate
17 Dose Finding and Phase II Study of STI 571 in Advanced Soft Tissue Sarcoma Completed NCT00006357 Phase 1, Phase 2 imatinib mesylate
18 Multicenter Parallel Phase II Trial of BI 2536 Administered as One Hour IV Infusion Every 3 Weeks in Defined Cohorts of Patients With Various Solid Tumors. A New Drug Screening Program of the EORTC Network of Core Institutions (NOCI) Completed NCT00526149 Phase 2 BI 2536
19 Phase II Trial of Chemotherapy in Sporadic and Neurofibromatosis Type 1 Associated High Grade Malignant Peripheral Nerve Sheath Tumors Completed NCT00304083 Phase 2 doxorubicin hydrochloride;etoposide;ifosfamide
20 Phase II Study of Preoperative Intensity-Modulated Radiation Therapy for Soft-Tissue Sarcomas Terminated NCT00740597 Phase 2
21 Phase I Study To Determine The Safety Of Caelyx (Doxorubin HCI, Pegylated Liposomal) In Combination With Ifosfamide In Previously Untreated Adult Patients With Advanced And/Or Metastatic Soft Tissues Sarcomas Completed NCT00030784 Phase 1 ifosfamide;pegylated liposomal doxorubicin hydrochloride
22 A Phase I Trial of Postoperative Radiation With Dose-Escalation of A Cox-2 Inhibitor, Celebrex™ (CELECOXIB) in Patients With Soft Tissue Sarcoma of the Extremity Completed NCT00450736 Phase 1 celecoxib
23 VORTEX-BIOBANK: Prospective Sample Collection for the VORTEX Randomised Radiotherapy Trial in Patients With Extremity Soft Tissue Sarcoma [VORTEX BIOBANK] Unknown status NCT00900211

Search NIH Clinical Center for Adult Malignant Schwannoma

Genetic Tests for Adult Malignant Schwannoma

Anatomical Context for Adult Malignant Schwannoma

MalaCards organs/tissues related to Adult Malignant Schwannoma:

41
Lung, Bone

Publications for Adult Malignant Schwannoma

Articles related to Adult Malignant Schwannoma:

# Title Authors PMID Year
1
Pediatric and adult malignant peripheral nerve sheath tumors: an analysis of data from the surveillance, epidemiology, and end results program. 38
24390465 2014

Variations for Adult Malignant Schwannoma

Expression for Adult Malignant Schwannoma

Search GEO for disease gene expression data for Adult Malignant Schwannoma.

Pathways for Adult Malignant Schwannoma

GO Terms for Adult Malignant Schwannoma

Sources for Adult Malignant Schwannoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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