MCID: ADL023
MIFTS: 44

Adult Medulloblastoma

Categories: Cancer diseases, Fetal diseases, Genetic diseases, Immune diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Adult Medulloblastoma

MalaCards integrated aliases for Adult Medulloblastoma:

Name: Adult Medulloblastoma 12 15
Adult Brain Medulloblastoma 12 71
Medulloblastoma, Adult 71

Classifications:



External Ids:

Disease Ontology 12 DOID:3864
MeSH 43 D008527
NCIt 49 C4011 C9373
UMLS 71 C0278876 C1332188

Summaries for Adult Medulloblastoma

MalaCards based summary : Adult Medulloblastoma, also known as adult brain medulloblastoma, is related to supratentorial primitive neuroectodermal tumor and cerebellar medulloblastoma, and has symptoms including vomiting, headache and gait ataxia. An important gene associated with Adult Medulloblastoma is KDM4C (Lysine Demethylase 4C), and among its related pathways/superpathways are Pathways in cancer and Signaling by Hedgehog. The drugs Donepezil and Fentanyl have been mentioned in the context of this disorder. Affiliated tissues include brain, liver and bone marrow, and related phenotypes are homeostasis/metabolism and embryo

Related Diseases for Adult Medulloblastoma

Diseases in the Medulloblastoma family:

Adult Medulloblastoma

Diseases related to Adult Medulloblastoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 85)
# Related Disease Score Top Affiliating Genes
1 supratentorial primitive neuroectodermal tumor 30.2 SHH MYCN
2 cerebellar medulloblastoma 29.7 SHH PTCH1 ATOH1
3 childhood medulloblastoma 29.5 SUFU PTCH1 MYCN GLI2
4 basal cell carcinoma 29.3 SUFU SHH PTCH1 MYCN GLI2
5 medulloblastoma 28.3 SUFU SHH SFRP1 PTCH1 MYCN KDM4C
6 holoprosencephaly 1 10.4 SHH GLI2
7 ovary leiomyosarcoma 10.3 SUFU PTCH1
8 polydactyly, preaxial ii 10.3 SHH PTCH1
9 holoprosencephaly, recurrent infections, and monocytosis 10.3 PTCH1 GLI2
10 medullomyoblastoma 10.3 SUFU SHH
11 calcifying epithelial odontogenic tumor 10.3 PTCH1 GLI2
12 central nervous system primitive neuroectodermal neoplasm 10.3 SHH MYCN
13 holoprosencephaly 5 10.3 SHH GLI2
14 holoprosencephaly 2 10.3 SHH GLI2
15 holoprosencephaly 4 10.3 SHH GLI2
16 culler-jones syndrome 10.2 SHH GLI2
17 corpus callosum lipoma 10.2 SHH GLI2
18 cerebral hemisphere lipoma 10.2 SHH GLI2
19 autonomic nervous system benign neoplasm 10.2 MYCN KDM4C
20 peripheral nervous system benign neoplasm 10.2 MYCN KDM4C
21 keratocystic odontogenic tumor 10.2 SUFU SHH PTCH1
22 hydrocephalus 10.2
23 holoprosencephaly 9 10.1 SHH PTCH1 GLI2
24 focal dermal hypoplasia 10.1 SUFU SHH PTCH1
25 midline interhemispheric variant of holoprosencephaly 10.1 SHH PTCH1 GLI2
26 septopreoptic holoprosencephaly 10.1 SHH PTCH1 GLI2
27 alobar holoprosencephaly 10.1 SHH PTCH1 GLI2
28 lobar holoprosencephaly 10.1 SHH PTCH1 GLI2
29 holoprosencephaly 11 10.1 SHH PTCH1 GLI2
30 solitary median maxillary central incisor 10.1 SHH PTCH1 GLI2
31 holoprosencephaly 3 10.1 SHH GLI2
32 brain stem glioma 10.1 SHH MYCN KDM4C
33 semilobar holoprosencephaly 10.1 SHH PTCH1 GLI2
34 pallister-hall syndrome 10.1 SHH PTCH1 GLI2
35 skeletal muscle cancer 10.1 SHH PTCH1 MYCN
36 rare tumor 10.1
37 supratentorial cancer 10.1 SHH MYCN
38 esophageal atresia 10.1 SHH MYCN GLI2
39 congenital nervous system abnormality 10.1 SHH PTCH1 GLI2
40 physical disorder 10.1 SHH PTCH1 GLI2
41 contractures, pterygia, and spondylocarpotarsal fusion syndrome 1a 10.0 SHH PTCH1 KDM4C
42 duodenal atresia 10.0 SHH MYCN
43 meningioma, radiation-induced 10.0
44 meningioma, familial 10.0
45 spinal meningioma 10.0
46 secretory meningioma 10.0
47 lymphoplasmacyte-rich meningioma 10.0
48 anus, imperforate 10.0 SHH GLI2
49 melanotic medulloblastoma 9.9 SUFU SHH PTCH1 GLI2
50 microform holoprosencephaly 9.9 SUFU SHH PTCH1 GLI2

Graphical network of the top 20 diseases related to Adult Medulloblastoma:



Diseases related to Adult Medulloblastoma

Symptoms & Phenotypes for Adult Medulloblastoma

UMLS symptoms related to Adult Medulloblastoma:


vomiting, headache, gait ataxia

MGI Mouse Phenotypes related to Adult Medulloblastoma:

45 (show all 12)
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.13 ATOH1 BRPF1 GLI2 KCNA1 KDM4C MYCN
2 embryo MP:0005380 10.02 BRPF1 GLI2 MYCN PTCH1 SFRP1 SHH
3 mortality/aging MP:0010768 10.02 ATOH1 BRPF1 GLI2 KCNA1 KDM4C MYCN
4 craniofacial MP:0005382 9.99 GLI2 MYCN PTCH1 SFRP1 SHH SUFU
5 digestive/alimentary MP:0005381 9.97 ATOH1 GLI2 MYCN PTCH1 SHH SUFU
6 integument MP:0010771 9.95 ATOH1 GLI2 KCNA1 KDM4C PTCH1 SHH
7 nervous system MP:0003631 9.91 ATOH1 BRPF1 GLI2 KCNA1 MYCN PTCH1
8 hearing/vestibular/ear MP:0005377 9.85 ATOH1 GLI2 KCNA1 PTCH1 SHH
9 limbs/digits/tail MP:0005371 9.85 GLI2 MYCN PTCH1 SFRP1 SHH SUFU
10 no phenotypic analysis MP:0003012 9.76 ATOH1 GLI2 KDM4C MYCN PTCH1 SFRP1
11 normal MP:0002873 9.5 ATOH1 BRPF1 GLI2 MYCN PTCH1 SHH
12 respiratory system MP:0005388 9.1 ATOH1 GLI2 MYCN PTCH1 SHH SUFU

Drugs & Therapeutics for Adult Medulloblastoma

Drugs for Adult Medulloblastoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 133)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Donepezil Approved Phase 3 120014-06-4 3152
2
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 3 437-38-7 3345
3 Pancreatic Polypeptide Investigational Phase 3 59763-91-6
4 Analgesics Phase 3
5 Neurotransmitter Agents Phase 3
6 Cholinesterase Inhibitors Phase 3
7 Cholinergic Agents Phase 3
8 Liver Extracts Phase 3
9 Cola Phase 3
10 Anesthetics Phase 3
11 Narcotics Phase 3
12 Analgesics, Opioid Phase 3
13 Anesthetics, General Phase 3
14 Anesthetics, Intravenous Phase 3
15
Vincristine Approved, Investigational Phase 2 57-22-7, 2068-78-2 5978
16
Cisplatin Approved Phase 2 15663-27-1 2767 441203 84093
17
Lenograstim Approved, Investigational Phase 2 135968-09-1
18
Cyclophosphamide Approved, Investigational Phase 2 50-18-0, 6055-19-2 2907
19
Pregabalin Approved, Investigational Phase 2 148553-50-8 5486971
20
Levetiracetam Approved Phase 2 102767-28-2 441341
21
Carmustine Approved, Investigational Phase 2 154-93-8 2578
22
Sargramostim Approved, Investigational Phase 2 83869-56-1, 123774-72-1
23
Paclitaxel Approved, Vet_approved Phase 2 33069-62-4 36314
24
Aldesleukin Approved Phase 2 85898-30-2, 110942-02-4
25
Thiotepa Approved, Investigational Phase 2 52-24-4 5453
26
Methotrexate Approved Phase 2 59-05-2, 1959-05-2 126941
27
leucovorin Approved Phase 2 58-05-9 6006 143
28
Doxorubicin Approved, Investigational Phase 2 23214-92-8 31703
29
Sodium citrate Approved, Investigational Phase 2 68-04-2
30
Tamoxifen Approved Phase 2 10540-29-1 2733526
31
Somatostatin Approved, Investigational Phase 2 38916-34-6, 51110-01-1 53481605
32
Octreotide Approved, Investigational Phase 2 83150-76-9 383414 6400441
33
Etoposide Approved Phase 2 33419-42-0 36462
34
Carboplatin Approved Phase 2 41575-94-4 10339178 38904 498142
35
nivolumab Approved Phase 2 946414-94-4
36
Iodine Approved, Investigational Phase 2 7553-56-2 807
37
Promethazine Approved, Investigational Phase 2 60-87-7 4927
38
Acetaminophen Approved Phase 2 103-90-2 1983
39
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 2 1177-87-3
40
Diphenhydramine Approved, Investigational Phase 2 58-73-1, 147-24-0 3100
41
Dexamethasone Approved, Investigational, Vet_approved Phase 2 50-02-2 5743
42
Folic acid Approved, Nutraceutical, Vet_approved Phase 2 59-30-3 6037
43
Citric acid Approved, Nutraceutical, Vet_approved Phase 2 77-92-9 311
44
Phenylalanine Approved, Investigational, Nutraceutical Phase 2 63-91-2 6140
45 Molgramostim Investigational Phase 2 99283-10-0
46 Tubulin Modulators Phase 2
47 Antirheumatic Agents Phase 2
48 Antimitotic Agents Phase 2
49 Hormones Phase 2
50 Psychotropic Drugs Phase 2

Interventional clinical trials:

(show all 42)
# Name Status NCT ID Phase Drugs
1 Phase III Double Blind, Placebo Controlled Study of Donepezil in the Irradiated Brain Completed NCT00369785 Phase 3 donepezil hydrochloride;Placebo
2 A Randomized, Double-blind, Placebo-controlled Multi-center Study to Evaluate the Safety and Efficacy of Fentanyl Sublingual Spray (Fentanyl SL Spray) for the Treatment of Breakthrough Cancer Pain Completed NCT00538850 Phase 3 Fentanyl sublingual spray;Placebo
3 A Phase II Trial of Preradiation Multiagent Chemotherapy for Adults With "Poor Risk" Medulloblastoma, PNET, and Disseminated Ependymoma Completed NCT00003309 Phase 2 cisplatin;cyclophosphamide;etoposide;vincristine sulfate
4 PHASE I STUDY OF ANTI-TENASCIN MONOCLONAL ANTIBODY 131I 81C6 VIA SURGICALLY CREATED CYSTIC RESECTION CAVITY IN THE TREATMENT OF PATIENTS WITH PRIMARY OR METASTATIC MALIGNANT BRAIN TUMORS Completed NCT00002752 Phase 1, Phase 2
5 Levetiracetam and Pregabalin for Monotherapy in Patients With Brain Tumors and Seizures. A Phase II Randomized Study. Completed NCT00629889 Phase 2 levetiracetam;pregabalin
6 Phase II Trial Of High Dose Cyclophosphamide, Cisplatin And Carmustine With Stem Cell Reconstitution Followed By Specific Cellular Therapy In Patients With Recurrent Or Refractory Brain Tumors Completed NCT00014573 Phase 2 carmustine;cisplatin;cyclophosphamide;paclitaxel
7 CAMP 013:- Tandem Thiotepa Regimen For Selected Malignant Gliomas:1) Primary Or Recurrent Glioblastoma Multiforme (GBM); and 2) Recurrent Anaplastic Astrocytomas (AA), Oligodendrogliomas (O), Oligoastrocytomas (OA), Ependymomas And Primitive Neuroectodermal Tumors (PNET) That Have Either Progressed After Primary Therapy Or Are Refractory To Standard Chemotherapy Completed NCT00008008 Phase 2 cyclophosphamide;thiotepa
8 CAMP 004A - Phase 2 Study Of Intensive Chemotherapy (BET) For Selected Categories Of Malignant Central Nervous System Tumor Completed NCT00007982 Phase 2 carmustine;cisplatin;cyclophosphamide;etoposide;thiotepa
9 Dose Intensive Chemotherapy for Patients Greater Than or Equal To 10 Years of Age With Newly Diagnosed High Stage Medulloblastoma, Supratentorial Primitive Neuroectodermal Tumors (PNET) and Ependymoma: A Feasibility Study of an Intensive Induction Chemotherapy Regimen Followed by Standard Irradiation Completed NCT00006258 Phase 2 cisplatin;cyclophosphamide;etoposide;methotrexate;vincristine sulfate
10 Phase I Study of Intra-Tumoral, Radiolabeled, Anti-Tenascin Monoclonal Antibody 81C6 in the Treatment of Patients With Malignant Primary Brain Tumors Completed NCT00003478 Phase 1, Phase 2
11 Phase I Study of At-Labeled Anti-Tenascin Human/Mouse Chimeric Monoclonal Antibody 81C6 (ch81C6) Via Surgically Created Cystic Resection Cavity in the Treatment of Patients With Primary or Metastatic Brain Tumors Completed NCT00003461 Phase 1, Phase 2
12 Cisplatin, Doxorubicin and Tamoxifen in the Treatment of Incurable Soft Tissue and Endocrine Malignancies Completed NCT00002608 Phase 2 cisplatin;doxorubicin hydrochloride;tamoxifen citrate
13 Donepezil and EGb761 in Improving Neurocognitive Function in Patients Who Have Previously Undergone Radiation Therapy for Primary Brain Tumor or Brain Metastases Completed NCT00070161 Phase 2 donepezil hydrochloride
14 Comparator Study of 68Ga-DOTATOC PET/CT With Octreoscan + High-resolution, Contrast-enhanced CT for Diagnosis and Staging in Neuroendocrine Tumors and Other Somatostatin Receptor Positive Tumors Completed NCT01869725 Phase 2
15 A Phase II Clinical Trial Evaluating the Efficacy and Safety of GDC-0449 in Adults With Recurrent or Refractory Medulloblastoma Completed NCT00939484 Phase 2 Vismodegib
16 National, Multicentric, Prospective Phase II Study Estimating the Interest of a Dose Decrease for Radiation Therapy Associated With a Carboplatine and Etoposide Based Chemotherapy for the Treatment of Standard Risk Adult Medulloblastomas Recruiting NCT01857453 Phase 2 carboplatine;Etoposide
17 Phase II Trial of the Immune Checkpoint Inhibitor Nivolumab in Patients With Select Rare CNS Cancers Recruiting NCT03173950 Phase 2 Nivolumab
18 Phase II Study of Intrathecal I-3F8 in Patients With GD2-Expressing Central Nervous System and Leptomeningeal Neoplasms Active, not recruiting NCT00445965 Phase 2
19 Photodynamic Therapy For Childhood Brain Tumors, A Phase I Study Unknown status NCT00002647 Phase 1 verteporfin
20 Phase I Pilot Study of Stereotaxic Radiosurgery in Patients With Intracranial Neoplasms Completed NCT00019578 Phase 1
21 Dose Escalation of Temozolomide in Combination With Thiotepa and Carboplatin With Autologous Stem Cell Rescue in Patients With Malignant Brain Tumors With Minimal Residual Disease Completed NCT00025558 Phase 1 carboplatin;temozolomide;thiotepa
22 Phase I Study of Anti-Tenascin Monoclonal Antibody I-Labeled 81C6 Via Surgically Created Cystic Resection Cavity in the Treatment of Patients With Primary Brain Tumors After External Beam Radiotherapy Completed NCT00003484 Phase 1 carmustine;irinotecan hydrochloride
23 A Pilot Feasibility, Dose-Escalation Study Using Intracerebral Microdialysis to Assess the Neuropharmacodynamics of Temsirolimus in Patients With Primary or Metastatic Brain Tumors Completed NCT00784914 Phase 1 temsirolimus
24 A Phase I Study of Bortezomib and Temozolomide in Patients With Refractory Solid Tumors Completed NCT00544284 Phase 1 bortezomib;temozolomide
25 A Phase I Trial of Subcutaneous And/Or Oral Calcitriol [(1,25-COH)2D3] and Carboplatin in Advanced Solid Tumors Completed NCT00008086 Phase 1 carboplatin
26 A Pilot Study of Dose-Intensified Procarbazine, CCNU, Vincristine (PCV) for Poor Prognosis Pediatric and Adult Brain Tumors Utilizing Fibronectin-Assisted, Retroviral-Mediated Modification of CD34+ Peripheral Blood Cells With O6-Methylguanine DNA Methyltransferase Completed NCT00005796 Phase 1 lomustine;procarbazine hydrochloride;vincristine sulfate
27 A Phase I, Open-Label, Maximum Tolerated Single-Cycle and Four-Cycle Dose-Finding Study to Evaluation the Safety and Tolerability of 90Y-SMT 487 Administered by Intravenous Infusion to Subjects With Refractory Somatostatin-Receptor Positive Tumors Completed NCT00006368 Phase 1
28 A PHASE I STUDY OF THE COMBINATION OF CAI AND PACLITAXEL IN ADULT PATIENTS WITH REFRACTORY CANCERS OR LYMPHOMA Completed NCT00019019 Phase 1 carboxyamidotriazole;paclitaxel
29 Phase I Pharmacokinetic Trial of Thalidomide and Docetaxel: A Regimen Based on Anti-Angiogenic Therapeutic Principles Completed NCT00049296 Phase 1 docetaxel;thalidomide
30 A Phase I Study of an Oral Histone Deacetylase Inhibitor, MS-275, in Refractory Solid Tumors and Lymphomas Completed NCT00020579 Phase 1 entinostat
31 Phase I Study of Intrathecal 131-I-3F8 Monoclonal Antibody in Patients With GD2 Positive Leptomeningeal Neoplasms Completed NCT00003022 Phase 1
32 Phase I Study Of Intrathecal Radioimmunotherapy Using I-8H9 For Central Nervous System/Leptomeningeal Neoplasms Active, not recruiting NCT00089245 Phase 1 Iodine I 131 MOAB 8H9;Iodine I 131 MOAB 8H9
33 Intra-Arterial Melphalan (L-Phenylalanine Mustard) Administered in Conjunction With Osmotic Blood-Brain Barrier Disruption in Patients With Brain Malignancies: A Phase I Study Terminated NCT00253721 Phase 1 Melphalan
34 Identification of Genes Involved in the Pathogenesis of Gliomas by Transcriptome Analysis Completed NCT00967200
35 Magnetic Resonance Correlates of Glioma Tumor Burden Completed NCT00005082
36 Prospective Study on the Short-Term Adverse Effects From Gamma Knife Radiosurgery Completed NCT00255671
37 Temozolomide Induced Changes in Semen/Sperm Analysis in Men With Newly Diagnosed, Progressive or Recurrent Primary Malignant Brain Tumors Completed NCT00499798
38 San Francisco Bay Area Adult Glioma Prognosis Study Protocol Completed NCT01009307
39 A Trial Of Radioimmunotherapy, Reduced-Dose External Beam Craniospinal Radiation Therapy With IMRT Boost, And Chemotherapy For Patients With Standard-Risk Medulloblastoma Completed NCT00058370 cisplatin;lomustine;vincristine sulfate
40 A Pharmacokinetic Participation Questionnaire Study Completed NCT00890435
41 Evaluation of a Stress Reduction Program in Patients With Malignant Brain Tumors and Their Family Caregivers Completed NCT00376818
42 Perfusion Magnetic Resonance Imaging of Brain Tumors: Correlation With Indicators of Angiogenesis Withdrawn NCT00005790

Search NIH Clinical Center for Adult Medulloblastoma

Genetic Tests for Adult Medulloblastoma

Anatomical Context for Adult Medulloblastoma

MalaCards organs/tissues related to Adult Medulloblastoma:

40
Brain, Liver, Bone Marrow, Bone, Cerebellum, Spinal Cord

Publications for Adult Medulloblastoma

Articles related to Adult Medulloblastoma:

(show top 50) (show all 121)
# Title Authors PMID Year
1
Reduced-dose craniospinal irradiation is feasible for standard-risk adult medulloblastoma patients. 61
32567042 2020
2
Prognostic role of chemotherapy, radiotherapy dose, and extent of surgical resection in adult medulloblastoma. 61
32291240 2020
3
Salvage Re-irradiation Options in Adult Medulloblastoma: A Case Report and Review of the Literature. 61
32354920 2020
4
Neurocognitive functioning and health-related quality of life in adult medulloblastoma patients: long-term outcomes of the NOA-07 study. 61
32367436 2020
5
miR-196B-5P and miR-200B-3P Are Differentially Expressed in Medulloblastomas of Adults and Children. 61
32365560 2020
6
Tumor Location and Treatment Modality are Associated with Overall Survival in Adult Medulloblastoma. 61
32226663 2020
7
Updates on Management of Adult Medulloblastoma. 61
31236711 2019
8
Differential response of SHH-expressing adult medulloblastomas to the sonic hedgehog inhibitor vismodegib: whole-genome analysis. 61
31423907 2019
9
Patterns of Failure in Patients With Adult Medulloblastoma Presenting Without Extraneural Metastasis. 61
29045264 2018
10
Impact of postoperative residual tumor and meningeal dissemination in adult medulloblastoma: A retrospective analysis. 61
32136193 2018
11
Adult medulloblastoma: An oncology radiation therapy department experience with 22 cases. 61
32136194 2018
12
Medulloblastoma in Older Adults: A Case Report and Literature Review. 61
29883827 2018
13
Prognostic value of Ki-67 index in adult medulloblastoma after accounting for molecular subgroup: a retrospective clinical and molecular analysis. 61
29687281 2018
14
Adult Medulloblastoma: Occurrence of a Rare Event. 61
30397563 2018
15
Preradiation Chemotherapy for Adult High-risk Medulloblastoma: A Trial of the ECOG-ACRIN Cancer Research Group (E4397). 61
27635620 2018
16
A Rare Extra-Axial Midline Tentorial Adult Medulloblastoma with Dural-Tail Sign Mimicking a Meningioma. 61
29682065 2018
17
Medulloblastoma in adults : A retrospective single institution analysis. 61
29147840 2018
18
The Neuroradiological Spectra of Adult and Pediatric Medulloblastoma Differ : Results from a Literature-based Meta-analysis. 61
27334102 2018
19
Radiotherapy for Adult Medulloblastoma: Evaluation of Helical Tomotherapy, Volumetric Intensity Modulated Arc Therapy, and Three-Dimensional Conformal Radiotherapy and the Results of Helical Tomotherapy Therapy. 61
29750173 2018
20
Long-term outcomes of adult medulloblastoma patients treated with radiotherapy. 61
29019042 2018
21
Distinctive localization and MRI features correlate of molecular subgroups in adult medulloblastoma. 61
28808827 2017
22
Adjuvant chemotherapy and overall survival in adult medulloblastoma. 61
27540083 2017
23
Adult-onset medulloblastoma presenting as slow-growing, atypical mass: a case report. 61
30363229 2017
24
[Adolescent and Young Adults (AYAS) brain tumor national Web conference. On behalf of ANOCEF, GO-AJA and SFCE societies]. 61
27866682 2016
25
Complete and sustained response of adult medulloblastoma to first-line sonic hedgehog inhibition with vismodegib. 61
27682250 2016
26
Dynamic susceptibility contrast perfusion imaging in biopsy-proved adult medulloblastoma. 61
27262628 2016
27
Comment on: Adjuvant chemotherapy in adult medulloblastoma: is it an option for average-risk patients? 61
27278608 2016
28
Molecular subgroups of adult medulloblastoma: a long-term single-institution study. 61
27106407 2016
29
Adjuvant chemotherapy in adult medulloblastoma: is it an option for average-risk patients? 61
26940908 2016
30
Multicenter experience of adult medulloblastoma: A study of Anatolian Society of Medical Oncology (ASMO). 61
27273958 2016
31
Chemotherapy increases long-term survival in patients with adult medulloblastoma--a literature-based meta-analysis. 61
26359208 2016
32
[Adult medulloblastoma: Retrospective series of 21 patients]. 61
26706607 2016
33
[Prognostic factors of adult medulloblastomas: A review of the literature and perspectives]. 61
26657111 2016
34
Adult medulloblastoma: A rare case report and literature review. 61
27512610 2016
35
Outcomes of adult medulloblastoma treated with a multimodality approach: A tertiary cancer center experience. 61
26981508 2015
36
Adult medulloblastoma: clinical characters, prognostic factors, outcomes and patterns of relapse. 61
26026861 2015
37
[Evolution of the management of pediatric and adult medulloblastoma]. 61
26141663 2015
38
MOZ and MORF acetyltransferases: Molecular interaction, animal development and human disease. 61
25920810 2015
39
Radiotherapy for adult medulloblastoma: Long term result from a single institution. A review of prognostic factors and why we do need a multi-institutional cooperative program. 61
26109916 2015
40
New perspectives in the treatment of adult medulloblastoma in the era of molecular oncology. 61
25600839 2015
41
Deep sequencing identifies IDH1 R132S mutation in adult medulloblastoma. 61
24616312 2015
42
Extracranial recurrence in the bone marrow of adult medulloblastoma patient - a therapeutic trap. 61
25778341 2015
43
Patterns of care in adult medulloblastoma: results of an international online survey. 61
25026996 2014
44
Adult medulloblastoma: a single institution experience. 61
25316389 2014
45
Neuroradiology and histopathology in two cases of adult medulloblastoma. 61
24750703 2014
46
[Analysis of pathologic characteristics and prognosis in different subtypes of adult medulloblastoma]. 61
24842015 2014
47
Long-term outcomes and role of chemotherapy in adults with newly diagnosed medulloblastoma. 61
23111362 2014
48
Adult medulloblastoma: feasibility and effectiveness of utilising high-dose chemotherapy with autologous stem cell rescue in newly diagnosed patients. 61
24528821 2014
49
Prominent EMA 'dots' in tumour-induced Bergmann gliosis. 61
24117995 2014
50
Shedding light on adult medulloblastoma: current management and opportunities for advances. 61
24857151 2014

Variations for Adult Medulloblastoma

Expression for Adult Medulloblastoma

Search GEO for disease gene expression data for Adult Medulloblastoma.

Pathways for Adult Medulloblastoma

GO Terms for Adult Medulloblastoma

Biological processes related to Adult Medulloblastoma according to GeneCards Suite gene sharing:

(show all 36)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of apoptotic process GO:0043066 9.97 SHH SFRP1 GLI2 ATOH1
2 positive regulation of transcription, DNA-templated GO:0045893 9.85 SHH SFRP1 PTCH1 MYCN GLI2 BRPF1
3 anterior/posterior pattern specification GO:0009952 9.79 SHH SFRP1 GLI2
4 positive regulation of neuron differentiation GO:0045666 9.77 KDM4C GLI2 ATOH1
5 neural tube closure GO:0001843 9.74 SUFU SFRP1 PTCH1
6 pattern specification process GO:0007389 9.71 SHH PTCH1 GLI2
7 negative regulation of osteoblast differentiation GO:0045668 9.7 SUFU SFRP1 PTCH1
8 mammary gland development GO:0030879 9.67 PTCH1 GLI2
9 developmental growth GO:0048589 9.66 SHH GLI2
10 hair follicle morphogenesis GO:0031069 9.66 SHH GLI2
11 branching morphogenesis of an epithelial tube GO:0048754 9.65 SHH GLI2
12 dopaminergic neuron differentiation GO:0071542 9.65 SHH SFRP1
13 hindbrain development GO:0030902 9.65 SHH GLI2
14 dorsal/ventral pattern formation GO:0009953 9.65 SHH PTCH1 GLI2
15 cellular response to cholesterol GO:0071397 9.64 PTCH1 OSBPL7
16 osteoblast development GO:0002076 9.64 SHH GLI2
17 anatomical structure formation involved in morphogenesis GO:0048646 9.63 SHH GLI2
18 neuroblast proliferation GO:0007405 9.63 SHH KCNA1
19 somite development GO:0061053 9.62 SHH PTCH1
20 digestive tract morphogenesis GO:0048546 9.62 SHH SFRP1
21 smooth muscle tissue development GO:0048745 9.61 SHH PTCH1
22 prostate gland development GO:0030850 9.6 SHH PTCH1
23 metanephric collecting duct development GO:0072205 9.58 SHH PTCH1
24 positive regulation of T cell differentiation in thymus GO:0033089 9.58 SHH GLI2
25 smoothened signaling pathway involved in dorsal/ventral neural tube patterning GO:0060831 9.56 PTCH1 GLI2
26 mammary gland duct morphogenesis GO:0060603 9.55 PTCH1 GLI2
27 smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation GO:0021938 9.51 SHH GLI2
28 negative regulation of smoothened signaling pathway GO:0045879 9.5 SUFU PTCH1 GLI2
29 hindgut morphogenesis GO:0007442 9.49 SHH GLI2
30 smoothened signaling pathway involved in spinal cord motor neuron cell fate specification GO:0021776 9.46 SUFU GLI2
31 smoothened signaling pathway involved in ventral spinal cord interneuron specification GO:0021775 9.43 SUFU GLI2
32 spinal cord motor neuron differentiation GO:0021522 9.43 SHH PTCH1 GLI2
33 ventral midline development GO:0007418 9.4 SHH GLI2
34 dorsal/ventral neural tube patterning GO:0021904 9.33 SHH PTCH1 GLI2
35 smoothened signaling pathway GO:0007224 9.26 SUFU SHH PTCH1 GLI2
36 spinal cord dorsal/ventral patterning GO:0021513 8.8 SUFU SHH GLI2

Molecular functions related to Adult Medulloblastoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 patched binding GO:0005113 8.62 SHH PTCH1

Sources for Adult Medulloblastoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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