MCID: ADL023
MIFTS: 53

Adult Medulloblastoma

Categories: Cancer diseases, Fetal diseases, Genetic diseases, Immune diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Adult Medulloblastoma

MalaCards integrated aliases for Adult Medulloblastoma:

Name: Adult Medulloblastoma 12 15
Adult Brain Medulloblastoma 12 74
Medulloblastoma, Adult 74

Classifications:



External Ids:

Disease Ontology 12 DOID:3864
MeSH 45 D008527
NCIt 51 C4011 C9373

Summaries for Adult Medulloblastoma

MalaCards based summary : Adult Medulloblastoma, also known as adult brain medulloblastoma, is related to meningioma, familial and medulloblastoma, and has symptoms including vomiting, gait ataxia and headache. An important gene associated with Adult Medulloblastoma is SHH (Sonic Hedgehog Signaling Molecule), and among its related pathways/superpathways are Pathways in cancer and Signaling by Hedgehog. The drugs Fentanyl and Donepezil have been mentioned in the context of this disorder. Affiliated tissues include brain, bone and bone marrow, and related phenotypes are Decreased viability in esophageal squamous lineage and behavior/neurological

Related Diseases for Adult Medulloblastoma

Diseases in the Medulloblastoma family:

Adult Medulloblastoma

Diseases related to Adult Medulloblastoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 168)
# Related Disease Score Top Affiliating Genes
1 meningioma, familial 28.8 ENO2 GFAP SUFU SYP TP53
2 medulloblastoma 28.4 ATOH1 ENO2 GFAP GLI1 IDH1 MYCN
3 septopreoptic holoprosencephaly 10.4 PTCH1 SHH
4 midline interhemispheric variant of holoprosencephaly 10.4 PTCH1 SHH
5 microform holoprosencephaly 10.3 PTCH1 SHH SUFU
6 chordoid glioma 10.3 GFAP TP53
7 calcifying epithelial odontogenic tumor 10.3 PTCH1 TP53
8 frontal convexity meningioma 10.2 GFAP TP53
9 intracranial chondrosarcoma 10.2 IDH1 TP53
10 cerebellar astrocytoma 10.2 IDH1 TP53
11 gliofibroma 10.2 GFAP TP53
12 cerebral convexity meningioma 10.2 GFAP TP53
13 protoplasmic astrocytoma 10.2 GFAP TP53
14 meninges sarcoma 10.2 GFAP TP53
15 focal epithelial hyperplasia 10.2 GLI1 SHH TP53
16 ring chromosome 7 10.2 MDM2 TP53
17 zika virus infection 10.2 MDM2 TP53
18 basal cell nevus syndrome 10.1 GLI1 PTCH1 SHH SUFU
19 inflammatory liposarcoma 10.1 EIF5B MDM2
20 lung combined type small cell carcinoma 10.1 GFAP SYP
21 inflammatory mfh 10.1 GFAP MDM2
22 pleuropulmonary blastoma 10.1 MYCN SHH TP53
23 actinic cheilitis 10.1 MDM2 TP53
24 microcystic meningioma 10.1 ENO2 GFAP
25 mixed glioma 10.1 GFAP IDH1 TP53
26 glioma susceptibility 1 10.1 GFAP IDH1 TP53
27 spinal cancer 10.1 GFAP TP53
28 fibrillary astrocytoma 10.1 GFAP IDH1 TP53
29 spinal cord astrocytoma 10.1 GFAP IDH1 TP53
30 gastric tubular adenocarcinoma 10.1 GLI1 SHH SYP
31 chordoid meningioma 10.1 GFAP SYP
32 sclerosing liposarcoma 10.1 MDM2 TP53
33 brain glioma 10.1 GFAP IDH1 TP53
34 nodular medulloblastoma 10.1 GFAP GLI1 PTCH1 SUFU
35 lip cancer 10.0 MDM2 TP53
36 obstructive hydrocephalus 10.0 GFAP SUFU SYP
37 chiari malformation 10.0 GFAP SYP
38 intracranial cysts 10.0 ENO2 GFAP
39 goblet cell carcinoid 10.0 ATOH1 ENO2
40 pilomyxoid astrocytoma 10.0 GFAP SUFU SYP
41 tracheoesophageal fistula 10.0 MYCN SHH SYP
42 primitive neuroectodermal tumor of the cervix uteri 10.0 ENO2 GFAP
43 melanotic medulloblastoma 10.0 ENO2 GFAP
44 extraventricular neurocytoma 10.0 GFAP IDH1 SYP
45 olfactory groove meningioma 10.0 SYP TP53
46 periosteal osteogenic sarcoma 10.0 IDH1 MDM2 TP53
47 dysembryoplastic neuroepithelial tumor 10.0 GFAP IDH1 SYP
48 angiocentric glioma 10.0 GFAP IDH1 SYP
49 adrenal neuroblastoma 10.0 ENO2 MYCN
50 ependymoblastoma 10.0 GFAP TP53

Graphical network of the top 20 diseases related to Adult Medulloblastoma:



Diseases related to Adult Medulloblastoma

Symptoms & Phenotypes for Adult Medulloblastoma

UMLS symptoms related to Adult Medulloblastoma:


vomiting, gait ataxia, headache

GenomeRNAi Phenotypes related to Adult Medulloblastoma according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability in esophageal squamous lineage GR00235-A 9.32 ATOH1 BRPF1 EIF5B GFAP GLI1 IDH1

MGI Mouse Phenotypes related to Adult Medulloblastoma:

47 (show all 18)
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.35 ATOH1 BRPF1 ENO2 GFAP GLI1 KAT6A
2 growth/size/body region MP:0005378 10.31 BRPF1 ENO2 GFAP GLI1 IDH1 KAT6A
3 cellular MP:0005384 10.3 ATOH1 BRPF1 ENO2 GFAP GLI1 KAT6A
4 homeostasis/metabolism MP:0005376 10.26 ATOH1 BRPF1 GFAP IDH1 KAT6A MDM2
5 craniofacial MP:0005382 10.25 ENO2 GLI1 KAT6A MDM2 MYCN PTCH1
6 mortality/aging MP:0010768 10.25 ATOH1 BRPF1 GFAP GLI1 IDH1 KAT6A
7 digestive/alimentary MP:0005381 10.24 ATOH1 GFAP GLI1 KAT6A MDM2 MYCN
8 cardiovascular system MP:0005385 10.22 GFAP KAT6A MDM2 MYCN PTCH1 SFRP1
9 embryo MP:0005380 10.22 BRPF1 GLI1 KAT6A MDM2 MYCN PTCH1
10 nervous system MP:0003631 10.21 ATOH1 BRPF1 ENO2 GFAP GLI1 KAT6A
11 endocrine/exocrine gland MP:0005379 10.11 ATOH1 GLI1 KAT6A MDM2 PTCH1 SFRP1
12 limbs/digits/tail MP:0005371 10.11 GLI1 KAT6A MDM2 MYCN PTCH1 SFRP1
13 normal MP:0002873 10.03 ATOH1 BRPF1 GFAP GLI1 KAT6A MDM2
14 no phenotypic analysis MP:0003012 9.97 ATOH1 GLI1 MDM2 MYCN PTCH1 SFRP1
15 neoplasm MP:0002006 9.88 GLI1 MDM2 PTCH1 SHH SUFU TP53
16 reproductive system MP:0005389 9.76 GLI1 KAT6A MDM2 MYCN PTCH1 SFRP1
17 respiratory system MP:0005388 9.61 ATOH1 ENO2 GLI1 IDH1 MYCN PTCH1
18 skeleton MP:0005390 9.32 BRPF1 IDH1 KAT6A MDM2 MYCN PTCH1

Drugs & Therapeutics for Adult Medulloblastoma

Drugs for Adult Medulloblastoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 159)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 3 437-38-7 3345
2
Donepezil Approved Phase 3,Phase 2 120014-06-4 3152
3 Pancreatic Polypeptide Investigational Phase 3,Phase 1 59763-91-6
4 Narcotics Phase 3
5 Adjuvants, Anesthesia Phase 3
6 Analgesics Phase 3,Phase 2
7 Anesthetics, Intravenous Phase 3
8 Liver Extracts Phase 3,Phase 2,Phase 1
9 Anesthetics, General Phase 3
10 Anesthetics Phase 3
11 Analgesics, Opioid Phase 3
12 Central Nervous System Depressants Phase 3,Phase 2
13 Peripheral Nervous System Agents Phase 3,Phase 2
14 Cola Phase 3,Phase 1
15 Cholinesterase Inhibitors Phase 3,Phase 2
16 Neurotransmitter Agents Phase 3,Phase 2
17 Nootropic Agents Phase 3,Phase 2
18 Cholinergic Agents Phase 3,Phase 2
19
Octreotide Approved, Investigational Phase 2,Phase 1,Not Applicable 83150-76-9 6400441 383414
20
Somatostatin Approved, Investigational Phase 2,Phase 1 38916-34-6, 51110-01-1 53481605
21
Cyclophosphamide Approved, Investigational Phase 2 50-18-0, 6055-19-2 2907
22
Lenograstim Approved, Investigational Phase 2,Phase 1 135968-09-1
23
Etoposide Approved Phase 2 33419-42-0 36462
24
Vincristine Approved, Investigational Phase 2,Phase 1,Not Applicable 2068-78-2, 57-22-7 5978
25
Cisplatin Approved Phase 2,Not Applicable 15663-27-1 2767 441203 84093
26
Temozolomide Approved, Investigational Phase 1, Phase 2,Phase 2 85622-93-1 5394
27
Carmustine Approved, Investigational Phase 2,Phase 1 154-93-8 2578
28
Thiotepa Approved, Investigational Phase 2,Phase 1 52-24-4 5453
29
Methotrexate Approved Phase 2 1959-05-2, 59-05-2 126941
30
leucovorin Approved Phase 2 58-05-9 143 6006
31
Iodine Approved, Investigational Phase 1, Phase 2,Phase 2,Not Applicable 7553-56-2 807
32
Sargramostim Approved, Investigational Phase 2 123774-72-1, 83869-56-1
33
Pregabalin Approved, Illicit, Investigational Phase 2 148553-50-8 5486971
34
Levetiracetam Approved, Investigational Phase 2 102767-28-2 441341
35
Aldesleukin Approved Phase 2 110942-02-4, 85898-30-2
36
Paclitaxel Approved, Vet_approved Phase 2,Phase 1 33069-62-4 36314
37
Sodium Citrate Approved, Investigational Phase 2 68-04-2
38
Doxorubicin Approved, Investigational Phase 2 23214-92-8 31703
39
Tamoxifen Approved Phase 2 10540-29-1 2733526
40
Carboplatin Approved Phase 1, Phase 2 41575-94-4 10339178 38904 498142
41
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 2 1177-87-3
42
Dexamethasone Approved, Investigational, Vet_approved Phase 2 50-02-2 5743
43
Promethazine Approved, Investigational Phase 2 60-87-7 4927
44
Diphenhydramine Approved, Investigational Phase 2 147-24-0, 58-73-1 3100
45
Acetaminophen Approved Phase 2 103-90-2 1983
46
Mechlorethamine Approved, Investigational Phase 1, Phase 2 51-75-2 4033
47
Mannitol Approved, Investigational Phase 1, Phase 2 69-65-8 6251 453
48
Melphalan Approved Phase 1, Phase 2 148-82-3 460612 4053
49
Folic Acid Approved, Nutraceutical, Vet_approved Phase 2 59-30-3 6037
50
Calcium Approved, Nutraceutical Phase 2,Phase 1 7440-70-2 271

Interventional clinical trials:

(show all 49)
# Name Status NCT ID Phase Drugs
1 Fentanyl Sublingual Spray in Treating Patients With Breakthrough Cancer Pain Completed NCT00538850 Phase 3 Fentanyl sublingual spray;Placebo
2 Donepezil in Treating Patients Who Have Undergone Radiation Therapy for Brain Tumors Completed NCT00369785 Phase 3 donepezil hydrochloride;Placebo
3 Vismodegib in Treating Patients With Recurrent or Refractory Medulloblastoma Completed NCT00939484 Phase 2 Vismodegib
4 Ga-DOTATOC Versus Octreoscan + CT Completed NCT01869725 Phase 2
5 Combination Chemotherapy Plus Radiation Therapy in Treating Adult Patients With Brain Cancer Completed NCT00003309 Phase 2 cisplatin;cyclophosphamide;etoposide;vincristine sulfate
6 Plerixafor After Radiation Therapy and Temozolomide in Treating Patients With Newly Diagnosed High Grade Glioma Completed NCT01977677 Phase 1, Phase 2 temozolomide;plerixafor
7 Chemotherapy Plus Peripheral Stem Cell Transplant in Treating Patients With Central Nervous System Cancer Completed NCT00007982 Phase 2 carmustine;cisplatin;cyclophosphamide;etoposide;thiotepa
8 Combination Chemotherapy Followed by Radiation Therapy in Treating Patients With Medulloblastoma, Supratentorial Primitive Neuroectodermal Tumor, or Ependymoma Completed NCT00006258 Phase 2 cisplatin;cyclophosphamide;etoposide;methotrexate;vincristine sulfate
9 Radiolabeled Monoclonal Antibody Therapy in Treating Patients With Primary Brain Tumors Completed NCT00003478 Phase 1, Phase 2
10 Radiolabeled Monoclonal Antibody Therapy in Treating Patients With Primary or Metastatic Brain Cancers Completed NCT00002752 Phase 1, Phase 2
11 Thiotepa Followed by Peripheral Stem Cell or Bone Marrow Transplant in Treating Patients With Malignant Glioma Completed NCT00008008 Phase 2 cyclophosphamide;thiotepa
12 Levetiracetam or Pregabalin in Treating Seizures in Patients Undergoing Chemotherapy and/or Radiation Therapy For Primary Brain Tumors Completed NCT00629889 Phase 2 levetiracetam;pregabalin
13 Radiolabeled Monoclonal Antibody Therapy in Treating Patients With Primary or Metastatic Brain Tumors Completed NCT00003461 Phase 1, Phase 2
14 Chemotherapy and Vaccine Therapy Followed by Bone Marrow or Peripheral Stem Cell Transplantation and Interleukin-2 in Treating Patients With Recurrent or Refractory Brain Cancer Completed NCT00014573 Phase 2 carmustine;cisplatin;cyclophosphamide;paclitaxel
15 Phase II Studies Of Donepezil And Ginkgo Biloba In Irradiated Brain Tumor Completed NCT00070161 Phase 2 donepezil hydrochloride
16 Combination Chemotherapy and Tamoxifen in Treating Patients With Solid Tumors Completed NCT00002608 Phase 2 cisplatin;doxorubicin hydrochloride;tamoxifen citrate
17 Interest of a Dose Decrease for Radiotherapy Associated With Chemotherapy for Treatment of Standard Risk Adult Medulloblastomas Recruiting NCT01857453 Phase 2 carboplatine;Etoposide
18 Iodine I 131 Monoclonal Antibody 3F8 in Treating Patients With Central Nervous System Cancer or Leptomeningeal Cancer Active, not recruiting NCT00445965 Phase 2
19 Melphalan, Carboplatin, Mannitol, and Sodium Thiosulfate in Treating Patients With Recurrent or Progressive CNS Embryonal or Germ Cell Tumors Suspended NCT00983398 Phase 1, Phase 2 Carboplatin;Mannitol;Melphalan;Sodium Thiosulfate
20 Study of Vismodegib in Combination With Temozolomide Versus Temozolomide Alone in Patients With Medulloblastomas With an Activation of the Sonic Hedgehog Pathway Terminated NCT01601184 Phase 1, Phase 2 vismodegib;Temozolomide
21 Photodynamic Therapy With Porfimer Sodium in Treating Patients With Refractory Brain Tumors Unknown status NCT00002647 Phase 1 verteporfin
22 Stereotactic Radiosurgery in Treating Patients With Brain Tumors Completed NCT00019578 Phase 1
23 RO4929097, Temozolomide, and Radiation Therapy in Treating Patients With Newly Diagnosed Malignant Glioma Completed NCT01119599 Phase 1 Gamma-Secretase Inhibitor RO4929097;Temozolomide
24 Combination Chemotherapy Followed by Peripheral Stem Cell Transplantation or Bone Marrow Transplantation in Treating Patients With Brain Cancer Completed NCT00025558 Phase 1 carboplatin;temozolomide;thiotepa
25 Combination Chemotherapy Plus Gene Therapy in Treating Patients With CNS Tumors Completed NCT00005796 Phase 1 lomustine;procarbazine hydrochloride;vincristine sulfate
26 Calcitriol Plus Carboplatin in Treating Patients With Advanced Solid Tumors Completed NCT00008086 Phase 1 carboplatin
27 Radiolabeled Monoclonal Antibody Therapy After Radiation Therapy in Treating Patients With Primary Brain Tumors Completed NCT00003484 Phase 1 carmustine;irinotecan hydrochloride
28 A Feasibility, Dose-Escalation Study Using Intracerebral Microdialysis to Assess the Neuropharmacodynamics of Temsirolimus in Patients With Primary or Metastatic Brain Tumors Completed NCT00784914 Phase 1 temsirolimus
29 Bortezomib and Temozolomide in Treating Patients With Brain Tumors or Other Solid Tumors That Have Not Responded to Treatment Completed NCT00544284 Phase 1 bortezomib;temozolomide
30 Yttrium Y 90 SMT 487 in Treating Patients With Refractory or Recurrent Cancer Completed NCT00006368 Phase 1
31 Thalidomide and Docetaxel in Treating Patients With Advanced Cancer Completed NCT00049296 Phase 1 docetaxel;thalidomide
32 MS-275 in Treating Patients With Advanced Solid Tumors or Lymphoma Completed NCT00020579 Phase 1 entinostat
33 Carboxyamidotriazole and Paclitaxel in Treating Patients With Advanced Solid Tumors or Refractory Lymphomas Completed NCT00019019 Phase 1 carboxyamidotriazole;paclitaxel
34 Monoclonal Antibody Therapy in Treating Patients With Leptomeningeal Cancer Completed NCT00003022 Phase 1
35 Radiolabeled Monoclonal Antibody Therapy in Treating Patients With Refractory, Recurrent, or Advanced CNS or Leptomeningeal Cancer Recruiting NCT00089245 Phase 1
36 Positron Emission Tomography Using Fluorine F 18 EF5 to Find Oxygen in Tumor Cells of Patients Who Are Undergoing Surgery or Biopsy for Newly Diagnosed Brain Tumors Terminated NCT00110032 Phase 1 EF5
37 Melphalan With BBBD in Treating Patients With Brain Malignancies Terminated NCT00253721 Phase 1 Melphalan
38 Magnetic Resonance Imaging in Determining Extent of Cancer in Patients With Newly Diagnosed Glioma Completed NCT00005082 Not Applicable
39 Study of Blood and Cheek Cell Samples From Patients With Glioma Completed NCT01009307
40 Study of Tissue Samples From Patients With Glioma or Other Brain Tumors Completed NCT00967200
41 Decision Making About Participating in Pharmacokinetic Studies in Patients Enrolled in a Phase I Treatment Clinical Trial Completed NCT00890435
42 Changes in Semen or Sperm Caused by Temozolomide in Patients With Newly Diagnosed, Progressive, or Recurrent Primary Malignant Brain Tumors Completed NCT00499798
43 Stress Reduction Program in Patients With Malignant Brain Tumors and Their Family Caregivers Completed NCT00376818 Not Applicable
44 Acute Side Effects in Patients Who Are Undergoing Stereotactic Radiosurgery for Brain Tumors or Other Brain Disorders Completed NCT00255671
45 Intrathecal Radioimmunotherapy, Radiation Therapy, and Chemotherapy After Surgery in Treating Patients With Medulloblastoma Active, not recruiting NCT00058370 Not Applicable cisplatin;lomustine;vincristine sulfate
46 Gadobutrol Versus Gadopentetate Dimeglumine or Gadobenate Dimeglumine Before DCE-MRI in Diagnosing Patients With Multiple Sclerosis, Grade II-IV Glioma, or Brain Metastases Terminated NCT02967380 Not Applicable Gadobenate Dimeglumine;Gadobutrol
47 Yoga Therapy in Treating Patients With Malignant Brain Tumors Terminated NCT01234805 Not Applicable
48 Efficacy of 68Ga-DOTATOC Positron Emission Tomography (PET) CT in Children and Young Adults With Brain Tumors Withdrawn NCT02194452 Not Applicable
49 Perfusion Magnetic Resonance Imaging in Measuring the Growth of Blood Vessels in Newly Diagnosed Brain Tumors Withdrawn NCT00005790 Not Applicable

Search NIH Clinical Center for Adult Medulloblastoma

Genetic Tests for Adult Medulloblastoma

Anatomical Context for Adult Medulloblastoma

MalaCards organs/tissues related to Adult Medulloblastoma:

42
Brain, Bone, Bone Marrow, Lung, Pineal, Liver, Cervix

Publications for Adult Medulloblastoma

Articles related to Adult Medulloblastoma:

(show top 50) (show all 70)
# Title Authors Year
1
Patterns of Failure in Patients With Adult Medulloblastoma Presenting Without Extraneural Metastasis. ( 29045264 )
2018
2
Long-term outcomes of adult medulloblastoma patients treated with radiotherapy. ( 29019042 )
2018
3
A Rare Extra-Axial Midline Tentorial Adult Medulloblastoma with Dural-Tail Sign Mimicking a Meningioma. ( 29682065 )
2018
4
Prognostic value of Ki-67 index in adult medulloblastoma after accounting for molecular subgroup: a retrospective clinical and molecular analysis. ( 29687281 )
2018
5
Radiotherapy for Adult Medulloblastoma: Evaluation of Helical Tomotherapy, Volumetric Intensity Modulated Arc Therapy, and Three-Dimensional Conformal Radiotherapy and the Results of Helical Tomotherapy Therapy. ( 29750173 )
2018
6
Adult Medulloblastoma: Occurrence of a Rare Event. ( 30397563 )
2018
7
Distinctive localization and MRI features correlate of molecular subgroups in adult medulloblastoma. ( 28808827 )
2017
8
Adjuvant chemotherapy and overall survival in adult medulloblastoma. ( 27540083 )
2017
9
Complete and sustained response of adult medulloblastoma to first-line sonic hedgehog inhibition with vismodegib. ( 27682250 )
2016
10
Adult medulloblastoma: A rare case report and literature review. ( 27512610 )
2016
11
Comment on: Adjuvant chemotherapy in adult medulloblastoma: is it an option for average-risk patients? ( 27278608 )
2016
12
Multicenter experience of adult medulloblastoma: A study of Anatolian Society of Medical Oncology (ASMO). ( 27273958 )
2016
13
Dynamic susceptibility contrast perfusion imaging in biopsy-proved adult medulloblastoma. ( 27262628 )
2016
14
Molecular subgroups of adult medulloblastoma: a long-term single-institution study. ( 27106407 )
2016
15
Adjuvant chemotherapy in adult medulloblastoma: is it an option for average-risk patients? ( 26940908 )
2016
16
Chemotherapy increases long-term survival in patients with adult medulloblastoma--a literature-based meta-analysis. ( 26359208 )
2016
17
[Adult medulloblastoma: Retrospective series of 21 patients]. ( 26706607 )
2016
18
Outcomes of adult medulloblastoma treated with a multimodality approach: A tertiary cancer center experience. ( 26981508 )
2015
19
Radiotherapy for adult medulloblastoma: Long term result from a single institution. A review of prognostic factors and why we do need a multi-institutional cooperative program. ( 26109916 )
2015
20
Adult medulloblastoma: clinical characters, prognostic factors, outcomes and patterns of relapse. ( 26026861 )
2015
21
Extracranial recurrence in the bone marrow of adult medulloblastoma patient - a therapeutic trap. ( 25778341 )
2015
22
New perspectives in the treatment of adult medulloblastoma in the era of molecular oncology. ( 25600839 )
2015
23
Deep sequencing identifies IDH1 R132S mutation in adult medulloblastoma. ( 24616312 )
2015
24
Adult medulloblastoma: a single institution experience. ( 25316389 )
2014
25
Cushing's reflex in a rare case of adult medulloblastoma. ( 25215166 )
2014
26
Patterns of care in adult medulloblastoma: results of an international online survey. ( 25026996 )
2014
27
Shedding light on adult medulloblastoma: current management and opportunities for advances. ( 24857151 )
2014
28
Neuroradiology and histopathology in two cases of adult medulloblastoma. ( 24750703 )
2014
29
Adult medulloblastoma: feasibility and effectiveness of utilising high-dose chemotherapy with autologous stem cell rescue in newly diagnosed patients. ( 24528821 )
2014
30
Retreatment of recurrent adult medulloblastoma with radiotherapy: a case report and review of the literature. ( 23497715 )
2013
31
Local perspective on a rare brain tumour: adult medulloblastoma. ( 23279053 )
2013
32
Comprehensive high-resolution genomic profiling and cytogenetics of two pediatric and one adult medulloblastoma. ( 23896263 )
2013
33
Adult medulloblastoma associated with syringomyelia: a case report. ( 23691470 )
2012
34
A tale of two tumors: pediatric and adult medulloblastoma. ( 23330354 )
2012
35
Adult medulloblastoma, from spongioblastoma cerebelli to the present day: a review of treatment and the integration of molecular markers. ( 23330353 )
2012
36
A rare case of adult medulloblastoma with spinal metastasis. ( 23056969 )
2012
37
Adult medulloblastoma: multiagent chemotherapy with cisplatinum and etoposide: a single institutional experience. ( 21874383 )
2012
38
The role of radiotherapy in adult medulloblastoma: long-term single-institution experience and a review of the literature. ( 21805324 )
2012
39
Update on molecular and genetic alterations in adult medulloblastoma. ( 23864912 )
2012
40
Adult medulloblastoma comprises three major molecular variants. ( 21632505 )
2011
41
Atypical adult medulloblastoma. ( 21553317 )
2011
42
Preponderance of sonic hedgehog pathway activation characterizes adult medulloblastoma. ( 21107850 )
2011
43
Radiation-induced adult medulloblastoma: a two-case report and review of the literature. ( 20936325 )
2011
44
Adult medulloblastoma mimicking Lhermitte-Duclos disease: can diffusion weighted imaging help? ( 19439857 )
2009
45
Adult medulloblastoma and the "dural-tail" sign: rare mimic of a posterior petrous meningioma. ( 19285790 )
2009
46
Survival of patients with adult medulloblastoma: a population-based study. ( 18278809 )
2008
47
Boost Gamma Knife surgery during multimodality management of adult medulloblastoma. ( 18240913 )
2008
48
Neuroimaging abnormalities in adult medulloblastoma undergoing intensified therapy. ( 19192661 )
2008
49
MATH-1 production by an adult medulloblastoma suggestive of a cerebellar external granule cell precursor origin. ( 18032051 )
2008
50
Adult medulloblastoma: clinical profile and treatment results of 18 patients. ( 18078755 )
2008

Variations for Adult Medulloblastoma

Expression for Adult Medulloblastoma

Search GEO for disease gene expression data for Adult Medulloblastoma.

Pathways for Adult Medulloblastoma

GO Terms for Adult Medulloblastoma

Cellular components related to Adult Medulloblastoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytosol GO:0005829 9.73 BRPF1 EIF5B ENO2 GFAP GLI1 IDH1
2 MOZ/MORF histone acetyltransferase complex GO:0070776 8.8 BRPF1 KAT6A KAT6B

Biological processes related to Adult Medulloblastoma according to GeneCards Suite gene sharing:

(show all 28)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of gene expression GO:0010629 9.88 MDM2 MYCN SFRP1 SHH
2 cellular response to hypoxia GO:0071456 9.81 MDM2 SFRP1 TP53
3 negative regulation of transcription, DNA-templated GO:0045892 9.8 KAT6A KAT6B MDM2 PTCH1 SFRP1 TP53
4 neural tube closure GO:0001843 9.77 PTCH1 SFRP1 SUFU
5 canonical Wnt signaling pathway GO:0060070 9.74 GLI1 SFRP1 SHH
6 smoothened signaling pathway GO:0007224 9.72 GLI1 PTCH1 SHH
7 negative regulation of osteoblast differentiation GO:0045668 9.7 PTCH1 SFRP1 SUFU
8 dorsal/ventral pattern formation GO:0009953 9.65 GLI1 PTCH1 SHH
9 intermediate filament organization GO:0045109 9.63 GFAP SHH
10 histone H3 acetylation GO:0043966 9.63 BRPF1 KAT6A KAT6B
11 somite development GO:0061053 9.62 PTCH1 SHH
12 cellular response to estrogen stimulus GO:0071391 9.62 MDM2 SFRP1
13 dorsal/ventral neural tube patterning GO:0021904 9.61 PTCH1 SHH
14 positive regulation of production of miRNAs involved in gene silencing by miRNA GO:1903800 9.58 MYCN TP53
15 Bergmann glial cell differentiation GO:0060020 9.56 GFAP SHH
16 regulation of signal transduction by p53 class mediator GO:1901796 9.56 BRPF1 KAT6A MDM2 TP53
17 spinal cord dorsal/ventral patterning GO:0021513 9.54 SHH SUFU
18 positive regulation of smoothened signaling pathway GO:0045880 9.54 GLI1 SFRP1 SHH
19 smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation GO:0021938 9.49 GLI1 SHH
20 cellular response to actinomycin D GO:0072717 9.43 MDM2 TP53
21 ventral midline development GO:0007418 9.4 GLI1 SHH
22 digestive tract morphogenesis GO:0048546 9.33 GLI1 SFRP1 SHH
23 positive regulation of transcription, DNA-templated GO:0045893 9.28 KAT6B KAT6A GLI1 BRPF1 MYCN PTCH1
24 prostate gland development GO:0030850 9.13 GLI1 PTCH1 SHH
25 regulation of transcription, DNA-templated GO:0006355 10.15 ATOH1 KAT6A KAT6B MYCN SHH SUFU
26 multicellular organism development GO:0007275 10.1 ATOH1 GLI1 SFRP1 SHH SUFU TP53
27 positive regulation of transcription by RNA polymerase II GO:0045944 10.05 ATOH1 GLI1 KAT6A KAT6B MYCN SHH
28 negative regulation of apoptotic process GO:0043066 10 ATOH1 MDM2 SFRP1 SHH TP53

Molecular functions related to Adult Medulloblastoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 metal ion binding GO:0046872 9.85 BRPF1 EIF5B ENO2 GLI1 IDH1 KAT6A
2 identical protein binding GO:0042802 9.73 GFAP IDH1 MDM2 SFRP1 SYP TP53
3 transcription factor binding GO:0008134 9.62 KAT6A KAT6B SUFU TP53
4 H4 histone acetyltransferase activity GO:0010485 8.96 KAT6A KAT6B
5 patched binding GO:0005113 8.62 PTCH1 SHH

Sources for Adult Medulloblastoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
Content
Loading form....