MCID: ADL023
MIFTS: 54

Adult Medulloblastoma

Categories: Cancer diseases, Neuronal diseases, Genetic diseases, Rare diseases

Aliases & Classifications for Adult Medulloblastoma

MalaCards integrated aliases for Adult Medulloblastoma:

Name: Adult Medulloblastoma 12 15
Adult Brain Medulloblastoma 12 73
Medulloblastoma, Adult 73

Classifications:



External Ids:

Disease Ontology 12 DOID:3864
MeSH 44 D008527
NCIt 50 C4011 C9373

Summaries for Adult Medulloblastoma

MalaCards based summary : Adult Medulloblastoma, also known as adult brain medulloblastoma, is related to gangliocytoma and medulloblastoma, and has symptoms including headache, vomiting and gait ataxia. An important gene associated with Adult Medulloblastoma is SHH (Sonic Hedgehog), and among its related pathways/superpathways are Pathways in cancer and Neuroscience. The drugs Carboplatin and Cisplatin have been mentioned in the context of this disorder. Affiliated tissues include brain, bone and bone marrow, and related phenotypes are Decreased viability in esophageal squamous lineage and growth/size/body region

Related Diseases for Adult Medulloblastoma

Diseases in the Medulloblastoma family:

Adult Medulloblastoma

Diseases related to Adult Medulloblastoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 152)
# Related Disease Score Top Affiliating Genes
1 gangliocytoma 29.8 GFAP SYP
2 medulloblastoma 26.3 ATOH1 ENO2 GFAP GLI1 IDH1 MYCN
3 septopreoptic holoprosencephaly 10.7 PTCH1 SHH
4 microform holoprosencephaly 10.7 PTCH1 SHH SUFU
5 midline interhemispheric variant of holoprosencephaly 10.7 PTCH1 SHH
6 calcifying epithelial odontogenic tumor 10.7 PTCH1 TP53
7 intracranial chondrosarcoma 10.7 IDH1 TP53
8 frontal convexity meningioma 10.7 GFAP TP53
9 cerebellar astrocytoma 10.6 IDH1 TP53
10 gliofibroma 10.6 GFAP TP53
11 spinal cord glioma 10.6 TP53 TUBB3
12 ring chromosome 7 10.6 MDM2 TP53
13 zika virus infection 10.6 MDM2 TP53
14 cerebral convexity meningioma 10.6 GFAP TP53
15 protoplasmic astrocytoma 10.6 GFAP TP53
16 actinic cheilitis 10.5 MDM2 TP53
17 lung combined type small cell carcinoma 10.4 GFAP SYP
18 basal cell nevus syndrome 10.4 GLI1 PTCH1 SHH SUFU
19 childhood medulloblastoma 10.3 MYCN PTCH1 SUFU
20 mixed glioma 10.3 GFAP IDH1 TP53
21 fibrillary astrocytoma 10.3 GFAP IDH1 TP53
22 gastric tubular adenocarcinoma 10.3 GLI1 SHH SYP
23 spinal cord astrocytoma 10.3 GFAP IDH1 TP53
24 periosteal osteogenic sarcoma 10.3 IDH1 MDM2 TP53
25 intracranial cysts 10.3 ENO2 GFAP
26 inflammatory mfh 10.2 GFAP MDM2
27 pancreas adenocarcinoma 10.2 GLI1 SHH TP53
28 rhabdoid meningioma 10.2 GFAP SYP
29 primitive neuroectodermal tumor of the cervix uteri 10.2 ENO2 GFAP
30 melanotic medulloblastoma 10.2 ENO2 GFAP
31 pilomyxoid astrocytoma 10.2 GFAP SUFU SYP
32 breast papillary carcinoma 10.2 IDH1 PTCH1 SYP
33 nodular medulloblastoma 10.2 GFAP GLI1 PTCH1 SUFU
34 extraventricular neurocytoma 10.1 GFAP IDH1 SYP
35 grade iii astrocytoma 10.1 GFAP MDM2 TP53
36 li-fraumeni syndrome 10.1 IDH1 MDM2 TP53
37 ureter small cell carcinoma 10.1 ENO2 SYP
38 pleomorphic adenoma 10.1 GFAP MDM2 TP53
39 dysembryoplastic neuroepithelial tumor 10.1 GFAP IDH1 SYP
40 angiocentric glioma 10.1 GFAP IDH1 SYP
41 malignant sertoli cell tumor 10.1 ENO2 SYP
42 urinary bladder small cell neuroendocrine carcinoma 10.1 ENO2 SYP
43 adrenal neuroblastoma 10.1 ENO2 MYCN
44 cellular ependymoma 10.1 GFAP SYP TP53
45 cerebellopontine angle tumor 10.1 GFAP IDH1 SYP
46 goblet cell carcinoid 10.1 ATOH1 ENO2
47 papilloma of choroid plexus 10.1 GFAP SYP TP53
48 auditory system cancer 10.1 ENO2 SYP
49 inflammatory liposarcoma 10.1 EIF5B MDM2
50 chordoid meningioma 10.1 GFAP SYP

Graphical network of the top 20 diseases related to Adult Medulloblastoma:



Diseases related to Adult Medulloblastoma

Symptoms & Phenotypes for Adult Medulloblastoma

UMLS symptoms related to Adult Medulloblastoma:


headache, vomiting, gait ataxia

GenomeRNAi Phenotypes related to Adult Medulloblastoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability in esophageal squamous lineage GR00235-A 9.4 ATOH1 BRPF1 EIF5B GFAP GLI1 IDH1

MGI Mouse Phenotypes related to Adult Medulloblastoma:

46 (show all 19)
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 10.37 TP53 ENO2 IDH1 GFAP BRPF1 GLI1
2 behavior/neurological MP:0005386 10.36 TP53 SYP BRPF1 GLI1 ENO2 GFAP
3 cellular MP:0005384 10.35 TP53 TUBB3 BRPF1 GLI1 ENO2 GFAP
4 mortality/aging MP:0010768 10.33 TP53 TUBB3 IDH1 GFAP ATOH1 BRPF1
5 digestive/alimentary MP:0005381 10.29 TP53 GFAP ATOH1 GLI1 PPP1R12A KAT6A
6 homeostasis/metabolism MP:0005376 10.29 TP53 SUFU BRPF1 IDH1 GFAP ATOH1
7 cardiovascular system MP:0005385 10.27 TP53 SUFU GFAP MYCN PPP1R12A MDM2
8 craniofacial MP:0005382 10.26 TP53 ENO2 GLI1 MDM2 KAT6A MYCN
9 embryo MP:0005380 10.24 TP53 SUFU GLI1 BRPF1 MDM2 KAT6A
10 nervous system MP:0003631 10.24 TUBB3 SYP TP53 ENO2 GFAP KAT6A
11 immune system MP:0005387 10.19 TP53 SUFU IDH1 GFAP PPP1R12A MDM2
12 limbs/digits/tail MP:0005371 10.13 TP53 GLI1 MDM2 KAT6A MYCN SFRP1
13 normal MP:0002873 10.03 SYP TP53 GFAP ATOH1 GLI1 BRPF1
14 muscle MP:0005369 9.98 TP53 GFAP MYCN PPP1R12A MDM2 PTCH1
15 no phenotypic analysis MP:0003012 9.97 TP53 SUFU GLI1 ATOH1 MDM2 MYCN
16 neoplasm MP:0002006 9.88 TP53 SUFU GLI1 MDM2 PTCH1 SHH
17 renal/urinary system MP:0005367 9.7 TP53 GLI1 MYCN PPP1R12A MDM2 SHH
18 respiratory system MP:0005388 9.65 TUBB3 TP53 ENO2 IDH1 ATOH1 GLI1
19 skeleton MP:0005390 9.32 TP53 SUFU BRPF1 IDH1 MDM2 KAT6A

Drugs & Therapeutics for Adult Medulloblastoma

Drugs for Adult Medulloblastoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 298)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Carboplatin Approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 41575-94-4 10339178 498142 38904
2
Cisplatin Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 15663-27-1 84093 441203 2767
3
Cyclophosphamide Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1 50-18-0, 6055-19-2 2907
4
Etoposide Approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1 33419-42-0 36462
5
Lenograstim Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 135968-09-1
6
Methotrexate Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 1959-05-2, 59-05-2 126941
7
Thiotepa Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 52-24-4 5453
8
Vincristine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 2068-78-2, 57-22-7 5978
9
Mesna Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 3375-50-6 598
10
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 59-30-3 6037
11
leucovorin Approved, Nutraceutical Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 58-05-9 143 6006
12 Alkylating Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
13 Antimetabolites Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
14 Antimetabolites, Antineoplastic Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
15 Antimitotic Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
16 Antineoplastic Agents, Alkylating Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
17 Antineoplastic Agents, Phytogenic Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
18 Antirheumatic Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
19 Dermatologic Agents Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable,Early Phase 1
20 Etoposide phosphate Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1
21 Folic Acid Antagonists Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
22 Immunosuppressive Agents Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1
23 Nucleic Acid Synthesis Inhibitors Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
24 Topoisomerase Inhibitors Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1
25 Vitamin B Complex Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
26 Folate Nutraceutical Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
27 Vitamin B9 Nutraceutical Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
28
Lomustine Approved, Investigational Phase 3,Phase 2,Phase 1,Not Applicable 13010-47-4 3950
29
Dacarbazine Approved, Investigational Phase 2, Phase 3,Phase 1 4342-03-4 5351166
30
Temozolomide Approved, Investigational Phase 2, Phase 3,Phase 3,Phase 1 85622-93-1 5394
31
Melphalan Approved Phase 2, Phase 3,Phase 1,Not Applicable 148-82-3 4053 460612
32
Levoleucovorin Approved, Investigational Phase 3,Phase 2,Early Phase 1 68538-85-2
33
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 3 437-38-7 3345
34
Donepezil Approved Phase 3,Phase 2,Early Phase 1 120014-06-4 3152
35
Dexamethasone Approved, Investigational, Vet_approved Phase 3,Phase 2,Phase 1 50-02-2 5743
36
Granisetron Approved, Investigational Phase 3 109889-09-0 3510
37
Ondansetron Approved Phase 3 99614-02-5 4595
38
Isotretinoin Approved Phase 3,Phase 2,Phase 1,Not Applicable 4759-48-2 5538 5282379
39
Cyproheptadine Approved Phase 3,Phase 2 129-03-3 2913
40
Histamine Approved, Investigational Phase 3,Phase 2 75614-87-8, 51-45-6 774
41
Metformin Approved Phase 3 657-24-9 14219 4091
42 Trofosfamide Investigational Phase 2, Phase 3 22089-22-1
43 Pancreatic Polypeptide Investigational Phase 3,Phase 1 59763-91-6
44 Adjuvants, Immunologic Phase 3,Phase 2,Phase 1,Not Applicable
45 Protective Agents Phase 3,Phase 2,Phase 1,Not Applicable
46 Liver Extracts Phase 3,Phase 2,Phase 1
47 Antidotes Phase 3,Phase 2,Phase 1
48 Calcium, Dietary Phase 3,Phase 2,Phase 1
49 Micronutrients Phase 3,Phase 2,Phase 1
50 Trace Elements Phase 3,Phase 2,Phase 1

Interventional clinical trials:

(show top 50) (show all 254)
# Name Status NCT ID Phase Drugs
1 HeadStart4: Newly Diagnosed Children (<10 y/o) With Medulloblastoma and Other CNS Embryonal Tumors Recruiting NCT02875314 Phase 4 Induction;Single Cycle Intensive Chemotherapy;Tandem 3 Cycle Intensive Chemotherapy
2 Radiation Therapy Plus Combination Chemotherapy in Treating Children With Medulloblastoma Unknown status NCT00053872 Phase 3 cisplatin;lomustine;vincristine sulfate
3 Therapy Optimization Trial for the Treatment of Relapsed or Refractory Brain Tumors in Children Unknown status NCT00749723 Phase 2, Phase 3 carboplatin;etoposide;temozolomide;thiotepa, carboplatin, etoposide;temozolomide, thiotepa;etoposide;trofosfamide/etoposide
4 Stem Cell Transplant for High Risk Central Nervous System (CNS) Tumors Unknown status NCT00179803 Phase 2, Phase 3
5 Combination Chemotherapy With or Without Etoposide Followed By an Autologous Stem Cell Transplant in Treating Young Patients With Previously Untreated Malignant Brain Tumors Unknown status NCT00392886 Phase 3 carboplatin;cisplatin;cyclophosphamide;etoposide;methotrexate;temozolomide;thiotepa;vincristine sulfate
6 Comparison of Radiation Therapy Regimens in Combination With Chemotherapy in Treating Young Patients With Newly Diagnosed Standard-Risk Medulloblastoma Completed NCT00085735 Phase 3 Cisplatin;Cyclophosphamide;Lomustine;Vincristine Sulfate
7 Combination Chemotherapy Followed By Peripheral Stem Cell Transplant in Treating Young Patients With Newly Diagnosed Supratentorial Primitive Neuroectodermal Tumors or High-Risk Medulloblastoma Completed NCT00336024 Phase 3 etoposide;cyclophosphamide;cisplatin;carboplatin;thiotepa;methotrexate;leucovorin calcium;vincristine sulfate
8 Combination Chemotherapy Followed by Second-Look Surgery and Radiation Therapy in Treating Children With Nonmetastatic Medulloblastoma or Primitive Neuroectodermal Tumor Completed NCT00006461 Phase 3 cisplatin;cyclophosphamide;vincristine sulfate;etoposide
9 Radiation Therapy Plus Combination Chemotherapy in Treating Children With Medulloblastoma Completed NCT00002875 Phase 3 cisplatin;cyclophosphamide;lomustine;mesna;vincristine sulfate
10 Sodium Thiosulfate in Preventing Hearing Loss in Young Patients Receiving Cisplatin for Newly Diagnosed Germ Cell Tumor, Hepatoblastoma, Medulloblastoma, Neuroblastoma, Osteosarcoma, or Other Malignancy Completed NCT00716976 Phase 3 sodium thiosulfate
11 Fentanyl Sublingual Spray in Treating Patients With Breakthrough Cancer Pain Completed NCT00538850 Phase 3 Fentanyl sublingual spray;Placebo
12 Donepezil in Treating Patients Who Have Undergone Radiation Therapy for Brain Tumors Completed NCT00369785 Phase 3 donepezil hydrochloride;Placebo
13 Acupressure in Controlling Nausea in Young Patients Receiving Highly Emetogenic Chemotherapy Completed NCT01346267 Phase 3
14 International Society of Paediatric Oncology (SIOP) PNET 5 Medulloblastoma Recruiting NCT02066220 Phase 2, Phase 3 Reduced-intensity maintenance chemotherapy;Maintenance chemotherapy
15 Chemotherapy and Radiation Therapy in Treating Young Patients With Newly Diagnosed, Previously Untreated, High-Risk Medulloblastoma Recruiting NCT00392327 Phase 3 Vincristine Sulfate;Carboplatin;Cisplatin;Cyclophosphamide;Isotretinoin
16 Hyperfractionated Versus Conventionally Fractionated Radiotherapy in Standard Risk Medulloblastoma Active, not recruiting NCT01351870 Phase 3
17 Placebo Controlled Double Blind Crossover Trial of Metformin for Brain Repair in Children With Cranial-Spinal Radiation for Medulloblastoma Active, not recruiting NCT02040376 Phase 3 Metformin;Placebo
18 Treatment of Patients With Newly Diagnosed Medulloblastoma, Supratentorial Primitive Neuroectodermal Tumor, or Atypical Teratoid Rhabdoid Tumor Active, not recruiting NCT00085202 Phase 3 cisplatin;cyclophosphamide;vincristine
19 Study of Fixed vs. Flexible Filgrastim to Accelerate Bone Marrow Recovery After Chemotherapy in Children With Cancer Active, not recruiting NCT01987596 Phase 3
20 Cyproheptadine in Preventing Weight Loss in Children Receiving Chemotherapy for Cancer Terminated NCT01132547 Phase 3 cyproheptadine hydrochloride
21 Radiation Therapy and Combination Chemotherapy in Treating Young Patients With Metastatic Medulloblastoma Who Have Undergone Surgery Unknown status NCT00276666 Phase 2 cisplatin;lomustine;vincristine sulfate
22 High Risk Primitive Neuroectodermal (PNET) Brain Tumors in Childhood Unknown status NCT00180791 Phase 2 Etoposide, carboplatin, melphalan, cisplatin, thiotepa
23 Study of Vinorelbine and Cyclofosfamide Among Patients With Refractory Tumours or in Relapse Unknown status NCT00180947 Phase 2 Vinorelbine, cyclofosfamide
24 The Use of 5-aminolevulinic Acid (ALA) as an Intraoperative Tumor Marker for Resection of Pediatric Central Nervous System (CNS) Tumors Unknown status NCT02050243 Phase 1, Phase 2 5ALA
25 A Study of Aminolevulinic Acid (ALA) to Enhance Visualization and Resection of Malignant Glial Tumors of the Brain Unknown status NCT01403311 Phase 2 5-Aminolevuline Acid
26 Combination Chemotherapy With or Without Radiation Therapy in Treating Children With Brain Tumors Unknown status NCT00281905 Phase 2 carboplatin;cisplatin;cyclophosphamide;methotrexate;vincristine sulfate
27 Vismodegib in Treating Patients With Recurrent or Refractory Medulloblastoma Completed NCT00939484 Phase 2 Vismodegib
28 A Phase II Study of Oral LDE225 in Patients With Hedge-Hog (Hh)-Pathway Activated Relapsed Medulloblastoma (MB) Completed NCT01708174 Phase 2 LDE225;TMZ
29 Combination Chemotherapy in Treating Younger Patients With Newly Diagnosed, Non-Metastatic Desmoplastic Medulloblastoma Completed NCT02017964 Phase 2 Vincristine Sulfate;Cyclophosphamide;Methotrexate;Etoposide;Carboplatin
30 Vismodegib in Treating Younger Patients With Recurrent or Refractory Medulloblastoma Completed NCT01239316 Phase 2 Vismodegib
31 Etoposide Plus Radiation Therapy Followed by Combination Chemotherapy in Treating Children With Newly Diagnosed Advanced Medulloblastoma Completed NCT00003573 Phase 2 cisplatin;cyclophosphamide;etoposide;vincristine sulfate
32 Concurrent Carboplatin and Reduced Dose Craniospinal Radiation for Medulloblastoma and Primitive Neuroectodermal Tumor (PNET) Completed NCT01542736 Phase 2 Carboplatin;Vincristine
33 Oxaliplatin in Treating Children With Recurrent or Refractory Medulloblastoma, Supratentorial Primitive Neuroectodermal Tumor, or Atypical Teratoid Rhabdoid Tumor Completed NCT00047177 Phase 2 Oxaliplatin
34 Bevacizumab and Irinotecan in Treating Young Patients With Recurrent, Progressive, or Refractory Glioma, Medulloblastoma, Ependymoma, or Low Grade Glioma Completed NCT00381797 Phase 2 Irinotecan Hydrochloride
35 Chemotherapy, Radiation Therapy, and Peripheral Stem Cell Transplantation in Treating Children With Newly Diagnosed Medulloblastoma or Supratentorial Primitive Neuroectodermal Tumor Completed NCT00003211 Phase 2 amifostine trihydrate;cisplatin;cyclophosphamide;vincristine sulfate
36 Combination Chemotherapy Followed by Bone Marrow and/or Peripheral Stem Cell Transplantation in Treating Patients With Recurrent Medulloblastoma or CNS Germ Cell Tumors Completed NCT00002594 Phase 2 cyclophosphamide;melphalan
37 Tipifarnib in Treating Young Patients With Recurrent or Progressive High-Grade Glioma, Medulloblastoma, Primitive Neuroectodermal Tumor, or Brain Stem Glioma Completed NCT00070525 Phase 2 tipifarnib
38 Combination of Irinotecan and Temozolomide in Children With Brain Tumors. Completed NCT00404495 Phase 2 Irinotecan;Temozolomide
39 Combination Chemotherapy Followed by Radiation Therapy in Treating Patients With Medulloblastoma, Supratentorial Primitive Neuroectodermal Tumor, or Ependymoma Completed NCT00006258 Phase 2 cisplatin;cyclophosphamide;etoposide;methotrexate;vincristine sulfate
40 A Phase I Dose Finding and Safety Study of Oral LDE225 in Children and a Phase II Portion to Assess Preliminary Efficacy in Recurrent or Refractory MB Completed NCT01125800 Phase 1, Phase 2 LDE225
41 Combination Chemotherapy, Surgery or Radiation Therapy, and Peripheral Stem Cell Transplant in Treating Patients With Recurrent Medulloblastoma or Primitive Neuroectodermal and Pineal Tumors Completed NCT00025077 Phase 2 carboplatin;cyclophosphamide;thiotepa
42 Combination Chemotherapy Plus Radiation Therapy in Treating Adult Patients With Brain Cancer Completed NCT00003309 Phase 2 cisplatin;cyclophosphamide;etoposide;vincristine sulfate
43 Lapatinib in Treating Young Patients With Recurrent or Refractory Central Nervous System Tumors Completed NCT00095940 Phase 1, Phase 2 lapatinib ditosylate
44 A Study of Pemetrexed in Children With Recurrent Cancer Completed NCT00520936 Phase 2 pemetrexed
45 Clinical Studies of Gemcitabine-Oxaliplatin Completed NCT00407433 Phase 2 Gemcitabine (Gemzar®), Oxaliplatin (Eloxatin®)
46 Rebeccamycin Analogue in Treating Children With Solid Tumors or Non-Hodgkin's Lymphoma Completed NCT00006102 Phase 2 becatecarin
47 Phenylbutyrate to Treat Children With Progressive or Recurrent Brain Tumors Completed NCT00006450 Phase 2 Phenylbutyrate
48 Irinotecan in Treating Children With Refractory Solid Tumors Completed NCT00004078 Phase 2 irinotecan hydrochloride
49 Topotecan Hydrochloride in Treating Children With Meningeal Cancer That Has Not Responded to Previous Treatment Completed NCT00005811 Phase 2 topotecan hydrochloride
50 Radiolabeled Monoclonal Antibody Therapy in Treating Patients With Primary or Metastatic Brain Cancers Completed NCT00002752 Phase 1, Phase 2

Search NIH Clinical Center for Adult Medulloblastoma

Genetic Tests for Adult Medulloblastoma

Anatomical Context for Adult Medulloblastoma

MalaCards organs/tissues related to Adult Medulloblastoma:

41
Brain, Bone, Bone Marrow, Spinal Cord, Testes, Pineal, Endothelial

Publications for Adult Medulloblastoma

Articles related to Adult Medulloblastoma:

(show top 50) (show all 70)
# Title Authors Year
1
Prognostic value of Ki-67 index in adult medulloblastoma after accounting for molecular subgroup: a retrospective clinical and molecular analysis. ( 29687281 )
2018
2
Radiotherapy for Adult Medulloblastoma: Evaluation of Helical Tomotherapy, Volumetric Intensity Modulated Arc Therapy, and Three-Dimensional Conformal Radiotherapy and the Results of Helical Tomotherapy Therapy. ( 29750173 )
2018
3
Long-term outcomes of adult medulloblastoma patients treated with radiotherapy. ( 29019042 )
2018
4
A Rare Extra-Axial Midline Tentorial Adult Medulloblastoma with Dural-Tail Sign Mimicking a Meningioma. ( 29682065 )
2018
5
Distinctive localization and MRI features correlate of molecular subgroups in adult medulloblastoma. ( 28808827 )
2017
6
Patterns of Failure in Patients With Adult Medulloblastoma Presenting Without Extraneural Metastasis. ( 29045264 )
2017
7
Adjuvant chemotherapy and overall survival in adult medulloblastoma. ( 27540083 )
2016
8
[Adult medulloblastoma: Retrospective series of 21 patients]. ( 26706607 )
2016
9
Multicenter experience of adult medulloblastoma: A study of Anatolian Society of Medical Oncology (ASMO). ( 27273958 )
2016
10
Molecular subgroups of adult medulloblastoma: a long-term single-institution study. ( 27106407 )
2016
11
Comment on: Adjuvant chemotherapy in adult medulloblastoma: is it an option for average-risk patients? ( 27278608 )
2016
12
Adult medulloblastoma: A rare case report and literature review. ( 27512610 )
2016
13
Adjuvant chemotherapy in adult medulloblastoma: is it an option for average-risk patients? ( 26940908 )
2016
14
Complete and sustained response of adult medulloblastoma to first-line sonic hedgehog inhibition with vismodegib. ( 27682250 )
2016
15
Dynamic susceptibility contrast perfusion imaging in biopsy-proved adult medulloblastoma. ( 27262628 )
2016
16
Extracranial recurrence in the bone marrow of adult medulloblastoma patient - a therapeutic trap. ( 25778341 )
2015
17
Adult medulloblastoma: clinical characters, prognostic factors, outcomes and patterns of relapse. ( 26026861 )
2015
18
Radiotherapy for adult medulloblastoma: Long term result from a single institution. A review of prognostic factors and why we do need a multi-institutional cooperative program. ( 26109916 )
2015
19
Outcomes of adult medulloblastoma treated with a multimodality approach: A tertiary cancer center experience. ( 26981508 )
2015
20
Chemotherapy increases long-term survival in patients with adult medulloblastoma-a literature-based meta-analysis. ( 26359208 )
2015
21
Neuroradiology and histopathology in two cases of adult medulloblastoma. ( 24750703 )
2014
22
Shedding light on adult medulloblastoma: current management and opportunities for advances. ( 24857151 )
2014
23
Adult medulloblastoma: a single institution experience. ( 25316389 )
2014
24
Patterns of care in adult medulloblastoma: results of an international online survey. ( 25026996 )
2014
25
Cushing's reflex in a rare case of adult medulloblastoma. ( 25215166 )
2014
26
New perspectives in the treatment of adult medulloblastoma in the era of molecular oncology. ( 25600839 )
2014
27
Deep Sequencing Identifies IDH1 R132S Mutation in Adult Medulloblastoma. ( 24616312 )
2014
28
Adult medulloblastoma: feasibility and effectiveness of utilising high-dose chemotherapy with autologous stem cell rescue in newly diagnosed patients. ( 24528821 )
2014
29
Local perspective on a rare brain tumour: adult medulloblastoma. ( 23279053 )
2013
30
Comprehensive high-resolution genomic profiling and cytogenetics of two pediatric and one adult medulloblastoma. ( 23896263 )
2013
31
Retreatment of recurrent adult medulloblastoma with radiotherapy: a case report and review of the literature. ( 23497715 )
2013
32
A rare case of adult medulloblastoma with spinal metastasis. ( 23056969 )
2012
33
Unusual presentation in adult medulloblastomas: imaging features mimicking cerebellar dysplastic gangliocytoma (Lhermitte-Duclos disease). ( 23135053 )
2012
34
Adult medulloblastoma associated with syringomyelia: a case report. ( 23691470 )
2012
35
Update on molecular and genetic alterations in adult medulloblastoma. ( 23864912 )
2012
36
Adult medulloblastoma: multiagent chemotherapy with cisplatinum and etoposide: a single institutional experience. ( 21874383 )
2012
37
The role of radiotherapy in adult medulloblastoma: long-term single-institution experience and a review of the literature. ( 21805324 )
2012
38
A tale of two tumors: pediatric and adult medulloblastoma. ( 23330354 )
2012
39
Adult medulloblastoma, from spongioblastoma cerebelli to the present day: a review of treatment and the integration of molecular markers. ( 23330353 )
2012
40
Atypical adult medulloblastoma. ( 21553317 )
2011
41
Preponderance of sonic hedgehog pathway activation characterizes adult medulloblastoma. ( 21107850 )
2011
42
Radiation-induced adult medulloblastoma: a two-case report and review of the literature. ( 20936325 )
2011
43
Adult medulloblastoma comprises three major molecular variants. ( 21632505 )
2011
44
Adult medulloblastoma and the &amp;quot;dural-tail&amp;quot; sign: rare mimic of a posterior petrous meningioma. ( 19285790 )
2009
45
Adult medulloblastoma mimicking Lhermitte-Duclos disease: can diffusion weighted imaging help? ( 19439857 )
2009
46
MATH-1 production by an adult medulloblastoma suggestive of a cerebellar external granule cell precursor origin. ( 18032051 )
2008
47
Survival of patients with adult medulloblastoma: a population-based study. ( 18278809 )
2008
48
Boost Gamma Knife surgery during multimodality management of adult medulloblastoma. ( 18240913 )
2008
49
Adult medulloblastoma: clinical profile and treatment results of 18 patients. ( 18078755 )
2008
50
Neuroimaging abnormalities in adult medulloblastoma undergoing intensified therapy. ( 19192661 )
2008

Variations for Adult Medulloblastoma

Expression for Adult Medulloblastoma

Search GEO for disease gene expression data for Adult Medulloblastoma.

Pathways for Adult Medulloblastoma

GO Terms for Adult Medulloblastoma

Cellular components related to Adult Medulloblastoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytosol GO:0005829 9.77 BRPF1 EIF5B ENO2 GFAP GLI1 IDH1
2 MOZ/MORF histone acetyltransferase complex GO:0070776 8.8 BRPF1 KAT6A KAT6B

Biological processes related to Adult Medulloblastoma according to GeneCards Suite gene sharing:

(show all 26)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of cell proliferation GO:0008284 9.98 GLI1 MDM2 MYCN SFRP1 SHH
2 negative regulation of gene expression GO:0010629 9.87 MDM2 MYCN SFRP1 SHH
3 negative regulation of transcription, DNA-templated GO:0045892 9.8 KAT6A KAT6B MDM2 PTCH1 SFRP1 TP53
4 lung development GO:0030324 9.77 GLI1 MYCN SHH
5 canonical Wnt signaling pathway GO:0060070 9.77 GLI1 SFRP1 SHH
6 neural tube closure GO:0001843 9.75 PTCH1 SFRP1 SUFU
7 smoothened signaling pathway GO:0007224 9.73 GLI1 PTCH1 SHH
8 regulation of signal transduction by p53 class mediator GO:1901796 9.73 BRPF1 KAT6A MDM2 TP53
9 negative regulation of osteoblast differentiation GO:0045668 9.69 PTCH1 SFRP1 SUFU
10 dorsal/ventral pattern formation GO:0009953 9.67 GLI1 PTCH1 SHH
11 histone H3 acetylation GO:0043966 9.65 BRPF1 KAT6A KAT6B
12 somite development GO:0061053 9.63 PTCH1 SHH
13 cellular response to estrogen stimulus GO:0071391 9.62 MDM2 SFRP1
14 dorsal/ventral neural tube patterning GO:0021904 9.61 PTCH1 SHH
15 Bergmann glial cell differentiation GO:0060020 9.55 GFAP SHH
16 spinal cord dorsal/ventral patterning GO:0021513 9.52 SHH SUFU
17 smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation GO:0021938 9.46 GLI1 SHH
18 positive regulation of smoothened signaling pathway GO:0045880 9.43 GLI1 SFRP1 SHH
19 cellular response to actinomycin D GO:0072717 9.4 MDM2 TP53
20 ventral midline development GO:0007418 9.37 GLI1 SHH
21 prostate gland development GO:0030850 9.33 GLI1 PTCH1 SHH
22 positive regulation of transcription, DNA-templated GO:0045893 9.28 BRPF1 GLI1 KAT6A KAT6B MYCN PTCH1
23 digestive tract morphogenesis GO:0048546 9.13 GLI1 SFRP1 SHH
24 regulation of transcription, DNA-templated GO:0006355 10.26 ATOH1 BRPF1 GLI1 KAT6A KAT6B MYCN
25 positive regulation of transcription by RNA polymerase II GO:0045944 10.08 ATOH1 GLI1 KAT6B MYCN PPP1R12A SHH
26 negative regulation of apoptotic process GO:0043066 10.02 ATOH1 MDM2 SFRP1 SHH TP53

Molecular functions related to Adult Medulloblastoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 acetyltransferase activity GO:0016407 8.96 KAT6A KAT6B
2 patched binding GO:0005113 8.62 PTCH1 SHH

Sources for Adult Medulloblastoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
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37 KEGG
38 LifeMap
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69 SNOMED-CT via HPO
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71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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