MEST
MCID: ADL014
MIFTS: 28

Adult Mesoblastic Nephroma (MEST)

Categories: Cancer diseases, Nephrological diseases, Rare diseases

Aliases & Classifications for Adult Mesoblastic Nephroma

MalaCards integrated aliases for Adult Mesoblastic Nephroma:

Name: Adult Mesoblastic Nephroma 12 15
Benign Mixed Epithelial and Stromal Tumor of Kidney 74
Mixed Epithelial and Stromal Tumour of Kidney 12
Benign Mest 12
Mest 12

Classifications:



External Ids:

Disease Ontology 12 DOID:2678
UMLS 74 C1272677

Summaries for Adult Mesoblastic Nephroma

Disease Ontology : 12 A mixed neoplasm that is seen mostly in early infancy and that consists of classic and cellular (atypical) variants.

MalaCards based summary : Adult Mesoblastic Nephroma, also known as benign mixed epithelial and stromal tumor of kidney, is related to silver-russell syndrome and arts syndrome, and has symptoms including flank pain An important gene associated with Adult Mesoblastic Nephroma is NTRK3 (Neurotrophic Receptor Tyrosine Kinase 3), and among its related pathways/superpathways are L1CAM interactions and Hematopoietic cell lineage. Affiliated tissues include kidney, and related phenotype is Negative genetic interaction between KRASG13D/+ and KRAS+/-.

Related Diseases for Adult Mesoblastic Nephroma

Diseases in the Adult Mesoblastic Nephroma family:

Congenital Mesoblastic Nephroma

Diseases related to Adult Mesoblastic Nephroma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 41)
# Related Disease Score Top Affiliating Genes
1 silver-russell syndrome 11.4
2 arts syndrome 11.2
3 retinitis pigmentosa 4 11.2
4 transient neonatal diabetes mellitus 11.2
5 cystic nephroma 11.1
6 mixed epithelial stromal tumour 11.1
7 iga glomerulonephritis 10.2
8 hepatosplenic t-cell lymphoma 10.2
9 angiomyolipoma 10.1
10 kidney disease 10.1
11 fibrosarcoma 10.1 ETV6 NTRK3
12 cellular congenital mesoblastic nephroma 10.1 ETV6 NTRK3
13 congenital mesoblastic nephroma 10.1 ETV6 NTRK3
14 pediatric fibrosarcoma 10.1 ETV6 NTRK3
15 congenital fibrosarcoma 10.0 ETV6 NTRK3
16 breast secretory carcinoma 10.0 ETV6 NTRK3
17 malignant mesenchymoma 10.0 ETV6 NTRK3
18 connective tissue cancer 10.0 CD34 NTRK3
19 differentiated thyroid carcinoma 10.0 ETV6 NTRK3
20 breast cancer 10.0
21 hepatocellular carcinoma 10.0
22 autism 10.0
23 lung cancer susceptibility 3 10.0
24 diabetes mellitus 10.0
25 male infertility 10.0
26 pre-eclampsia 10.0
27 gestational diabetes 10.0
28 adenocarcinoma 10.0
29 infertility 10.0
30 glioma 10.0
31 depression 10.0
32 sulfite oxidase deficiency due to molybdenum cofactor deficiency 10.0
33 nephrogenic adenofibroma 9.9 CD34 CHL1
34 precursor t-cell acute lymphoblastic leukemia 9.9 CD34 ETV6
35 acute leukemia 9.9 CD34 ETV6
36 peripheral nervous system neoplasm 9.9 CD34 CHL1
37 gastrointestinal stromal tumor 9.9 CD34 NTRK3
38 bone marrow cancer 9.9 CD34 ETV6
39 leukemia, chronic myeloid 9.8 CD34 ETV6
40 adult fibrosarcoma 9.8 CD34 ETV6 NTRK3
41 hematologic cancer 9.7 CD34 ETV6

Graphical network of the top 20 diseases related to Adult Mesoblastic Nephroma:



Diseases related to Adult Mesoblastic Nephroma

Symptoms & Phenotypes for Adult Mesoblastic Nephroma

UMLS symptoms related to Adult Mesoblastic Nephroma:


flank pain

GenomeRNAi Phenotypes related to Adult Mesoblastic Nephroma according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Negative genetic interaction between KRASG13D/+ and KRAS+/- GR00255-A-5 8.8 CD24 CD34 ETV6

Drugs & Therapeutics for Adult Mesoblastic Nephroma

Search Clinical Trials , NIH Clinical Center for Adult Mesoblastic Nephroma

Genetic Tests for Adult Mesoblastic Nephroma

Anatomical Context for Adult Mesoblastic Nephroma

MalaCards organs/tissues related to Adult Mesoblastic Nephroma:

42
Kidney

Publications for Adult Mesoblastic Nephroma

Articles related to Adult Mesoblastic Nephroma:

# Title Authors Year
1
Multiphasic contrast-enhanced CT and MRI findings of adult mesoblastic nephroma: A report of two cases. ( 23986620 )
2013
2
Mixed epithelial and stromal tumor of the kidney or adult mesoblastic nephroma: an update. ( 20845287 )
2010
3
Adult mesoblastic nephroma: a case with fatal recurrence. ( 18592471 )
2008
4
Adult mesoblastic nephroma: appearances on magnetic resonance imaging. ( 15288147 )
2004
5
Adult mesoblastic nephroma. ( 10707372 )
2000
6
Adult mesoblastic nephroma with ciliated epithelium. A case report. ( 10782471 )
2000
7
Adult mesoblastic nephroma: expansion of the morphologic spectrum and review of literature. ( 9669345 )
1998
8
A case of adult mesoblastic nephroma: ultrastructure and discussion of histogenesis. ( 2160549 )
1990

Variations for Adult Mesoblastic Nephroma

Expression for Adult Mesoblastic Nephroma

Search GEO for disease gene expression data for Adult Mesoblastic Nephroma.

Pathways for Adult Mesoblastic Nephroma

Pathways related to Adult Mesoblastic Nephroma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.25 CD24 CHL1
2 10.94 CD24 CD34
3 10.35 CD24 CD34

GO Terms for Adult Mesoblastic Nephroma

Biological processes related to Adult Mesoblastic Nephroma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell differentiation GO:0030154 9.5 CHL1 ETV6 NTRK3
2 cell-cell adhesion GO:0098609 9.26 CD24 CD34
3 neuron migration GO:0001764 9.16 CHL1 NTRK3
4 cell adhesion GO:0007155 9.13 CD24 CD34 CHL1
5 hematopoietic stem cell proliferation GO:0071425 8.62 CD34 ETV6

Sources for Adult Mesoblastic Nephroma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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