MCID: ADL008
MIFTS: 32

Adult Oligodendroglioma

Categories: Cancer diseases, Neuronal diseases, Rare diseases
Data Licensing
For inquiries, contact:

Aliases & Classifications for Adult Oligodendroglioma

MalaCards integrated aliases for Adult Oligodendroglioma:

Name: Adult Oligodendroglioma 11 14
Adult Brain Oligodendroglioma 11 71
Grade Ii Adult Oligodendroglial Tumor 11
Oligodendroglioma, Adult 71

Classifications:



External Ids:

Disease Ontology 11 DOID:3186
MeSH 43 D009837
NCIt 49 C4014 C9376
UMLS 71 C0279070 C1332190

Summaries for Adult Oligodendroglioma

MalaCards based summary: Adult Oligodendroglioma, also known as adult brain oligodendroglioma, is related to glioma susceptibility 1 and oligodendroglioma, and has symptoms including headache and seizures. An important gene associated with Adult Oligodendroglioma is KIAA1549 (KIAA1549), and among its related pathways/superpathways are Chromosome Maintenance and Effect of progerin on genes involved in Hutchinson-Gilford progeria syndrome. The drugs Bevacizumab and Everolimus have been mentioned in the context of this disorder. Affiliated tissues include brain and liver.

Related Diseases for Adult Oligodendroglioma

Diseases in the Oligodendroglioma family:

Adult Oligodendroglioma

Diseases related to Adult Oligodendroglioma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 113)
# Related Disease Score Top Affiliating Genes
1 glioma susceptibility 1 29.8 IDH2 IDH1 H3-3A
2 oligodendroglioma 29.4 OLIG2 IDH2 IDH1 FUBP1 FGFR1
3 enchondroma 10.3 IDH2 IDH1
4 chondroma 10.3 IDH2 IDH1
5 histoplasmosis meningitis 10.2 IDH2 IDH1
6 intracranial chondrosarcoma 10.2 IDH2 IDH1
7 anaplastic oligodendroglioma, idh-mutant and 1p/19q-codeleted 10.2 IDH2 IDH1
8 periosteal chondrosarcoma 10.2 IDH2 IDH1
9 juxtacortical chondroma 10.2 IDH2 IDH1
10 sinonasal undifferentiated carcinoma 10.2 IDH2 IDH1
11 gangliocytoma 10.2 KIAA1549 IDH1
12 spindle cell hemangioma 10.2 IDH2 IDH1
13 d-2-hydroxyglutaric aciduria 2 10.2 IDH2 IDH1
14 cerebellum cancer 10.2 KIAA1549 IDH1
15 2-hydroxyglutaric aciduria 10.2 IDH2 IDH1
16 papillary craniopharyngioma 10.2 KIAA1549 IDH1
17 optic nerve neoplasm 10.2 OLIG2 KIAA1549
18 paranasal sinus cancer 10.2 IDH2 IDH1
19 nasal cavity cancer 10.2 IDH2 IDH1
20 d-2-hydroxyglutaric aciduria 1 10.1 IDH2 IDH1
21 bone giant cell sarcoma 10.1 H3-3B H3-3A
22 childhood pilocytic astrocytoma 10.1 KIAA1549 FGFR1
23 periosteal osteogenic sarcoma 10.1 H3-3B H3-3A
24 angioimmunoblastic t-cell lymphoma 10.1 IDH2 IDH1
25 malignant giant cell tumor 10.1 H3-3B H3-3A
26 telangiectatic osteogenic sarcoma 10.1 H3-3B H3-3A
27 l-2-hydroxyglutaric aciduria 10.1 IDH2 IDH1
28 optic nerve glioma 10.1 OLIG2 KIAA1549 IDH1
29 posterior fossa ependymoma 10.1 H3-3B H3-3A
30 central neurocytoma 10.1 OLIG2 KIAA1549 IDH1
31 colon leiomyoma 10.1 H3-3B H3-3A
32 ossifying fibroma 10.1 H3-3B H3-3A
33 cerebellar astrocytoma 10.1 KIAA1549 IDH1 H3-3A
34 bone benign neoplasm 10.0 H3-3B H3-3A
35 simple partial epilepsy 10.0 KIAA1549 IDH1 FGFR1
36 bone giant cell tumor 10.0 H3-3B H3-3A
37 chronic leukemia 10.0 IDH2 IDH1 FGFR1
38 childhood brain stem glioma 10.0 IDH1 H3-3B H3-3A
39 clear cell chondrosarcoma 10.0 IDH1 H3-3B H3-3A
40 intracranial structure hemangioma 10.0 OLIG2 H3-3B H3-3A
41 intracranial cavernous angioma 10.0 OLIG2 H3-3B H3-3A
42 chordoid glioma 10.0 KIAA1549 IDH2 IDH1 FUBP1
43 benign giant cell tumor 10.0 H3-3B H3-3A
44 subependymal glioma 9.9 KIAA1549 IDH1 ATRX
45 idh-mutant anaplastic astrocytoma 9.9 IDH2 IDH1 ATRX
46 gemistocytic astrocytoma 9.9 IDH2 IDH1 ATRX
47 mixed oligodendroglioma-astrocytoma 9.9 IDH2 IDH1 ATRX
48 enchondromatosis, multiple, ollier type 9.9 IDH2 IDH1 ATRX
49 temporal lobe neoplasm 9.9 IDH1 FUBP1 ATRX
50 oculoectodermal syndrome 9.9 H3-3B H3-3A FGFR1

Graphical network of the top 20 diseases related to Adult Oligodendroglioma:



Diseases related to Adult Oligodendroglioma

Symptoms & Phenotypes for Adult Oligodendroglioma

UMLS symptoms related to Adult Oligodendroglioma:


headache; seizures

Drugs & Therapeutics for Adult Oligodendroglioma

Drugs for Adult Oligodendroglioma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 43)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Bevacizumab Approved, Investigational Phase 2 216974-75-3 135329020
2
Everolimus Approved Phase 2 159351-69-6 70789204 6442177
3
Sirolimus Approved, Investigational Phase 2 53123-88-9 5284616 6436030
4
Sunitinib Approved, Investigational Phase 2 557795-19-4 5329102
5
Miconazole Approved, Investigational, Vet_approved Phase 1, Phase 2 22916-47-8 4189
6
Clotrimazole Approved, Vet_approved Phase 1, Phase 2 23593-75-1 2812
7 Immunoglobulins, Intravenous Phase 2
8 Immunoglobulins Phase 2
9 Angiogenesis Inhibitors Phase 2
10 Antibodies, Monoclonal Phase 2
11 Antibodies Phase 2
12 Antineoplastic Agents, Immunological Phase 2
13 Immunologic Factors Phase 2
14 Immunosuppressive Agents Phase 2
15 Vaccines Phase 2
16
Imatinib Mesylate Phase 1, Phase 2 220127-57-1
17 Anti-Bacterial Agents Phase 1, Phase 2
18 Anti-Infective Agents Phase 1, Phase 2
19 Antifungal Agents Phase 1, Phase 2
20 Antibiotics, Antitubercular Phase 1, Phase 2
21
Temozolomide Approved, Investigational Phase 1 85622-93-1 5394
22
Erlotinib Approved, Investigational Phase 1 183319-69-9, 183321-74-6 176870
23
Isotretinoin Approved, Investigational, Nutraceutical Phase 1 302-79-4, 4759-48-2 5538 444795 5282379
24
Etanidazole Investigational Phase 1 22668-01-5 3276
25 Liver Extracts Phase 1
26 R04929097 Phase 1
27 Alkylating Agents Phase 1
28 Antineoplastic Agents, Alkylating Phase 1
29 Protein Kinase Inhibitors Phase 1
30 Fluorides Phase 1
31 Dermatologic Agents Phase 1
32
Edetate calcium disodium anhydrous Approved, Vet_approved 62-33-9, 60-00-4 6049
33
Iron Approved 7439-89-6 29936
34
Pentetic acid Approved 67-43-6
35
Dopamine Approved 62-31-7, 51-61-6 681
36
Imidazole Experimental, Investigational 288-32-4 795
37 Iron Chelating Agents
38 Antidotes
39 Protective Agents
40 Chelating Agents
41 Dihydroxyphenylalanine
42 Neurotransmitter Agents
43 Dopamine Agents

Interventional clinical trials:

(show all 24)
# Name Status NCT ID Phase Drugs
1 A Randomized Phase II Trial of Bevacizumab to Control Brain Radiation Damage Completed NCT00492089 Phase 2 bevacizumab;placebo
2 Phase II Trial of RAD001 in Patients With Recurrent Low Grade Glioma Completed NCT00823459 Phase 2 Everolimus
3 A Pharmacokinetic and Phase 2 Study of Sunitinib Malate in Recurrent Malignant Gliomas Completed NCT00499473 Phase 2 sunitinib malate
4 A Phase II Clinical Trial Evaluating Autologous Dendritic Cells Pulsed With Tumor Lysate Antigen for the Treatment of Low-grade Glioma Completed NCT01635283 Phase 2
5 Proton Radiation for Low Grade Gliomas Completed NCT01024907 Phase 1, Phase 2
6 Phase I/II Trial of Imatinib Mesylate; (Gleevec; STI571) in Treatment of Recurrent Oligodendroglioma and Mixed Oligoastrocytoma Completed NCT00049127 Phase 1, Phase 2 Imatinib Mesylate
7 Phase I/II Trial of Temsirolimus and Perifosine for Recurrent or Progressive Malignant Gliomas Completed NCT01051557 Phase 1, Phase 2 Perifosine;Temsirolimus
8 A Single-Arm, Open-label, Phase II Study Evaluating the Efficacy and Safety of Abemaciclib in Patients With Recurrent Oligodendroglioma Active, not recruiting NCT03969706 Phase 2 Abemaciclib 200 MG
9 Phase II Study of Antineoplastons A10 and AS2-1 in Adult Patients With Oligodendroglioma Terminated NCT00003472 Phase 2 Antineoplaston therapy (Atengenal + Astugenal)
10 Phase I Pilot Study of Stereotaxic Radiosurgery in Patients With Intracranial Neoplasms Completed NCT00019578 Phase 1
11 Phase I Study of OSI-774 (NSC 718781) for Solid Tumors in Patients With Hepatic or Renal Dysfunction Completed NCT00030498 Phase 1 erlotinib hydrochloride
12 Phase 1 Trial of RO4929097 in Combination With Standard Radiotherapy and Temozolomide for Newly Diagnosed Malignant Glioma: A Pharmacokinetic and Pharmacodynamic Study Completed NCT01119599 Phase 1 Gamma-Secretase Inhibitor RO4929097;Temozolomide
13 Phase I Study of Alisertib With Concurrent Fractionated Stereotactic Radiation Treatment for Recurrent High Grade Gliomas Completed NCT02186509 Phase 1 Alisertib
14 Microenvironment: Imaging/Implications in Brain Tumors; A Preliminary Investigation of the Biodistribution of [F-18]-EF5 in Patients With Brain Tumors Terminated NCT00110032 Phase 1 EF5
15 A Phase I Single Arm Open Label Study of Erlotinib and 13-cis-Retinoic Acid (CRA) in Patients With Recurrent Malignant Gliomas Terminated NCT01103375 Phase 1 erlotinib hydrochloride;isotretinoin
16 Natural History of Postoperative Cognitive Function, Quality of Life, and Seizure Control in Patients With Supratentorial Low-Risk Grade II Glioma Completed NCT01417507
17 A Pilot Study of Temporally-modulated Pulsed Radiation Therapy to Reirradiate Recurrent IDH-mutant Gliomas After Prior External Beam Radiation Therapy Recruiting NCT05393258
18 A Pilot Study of Utility of 18F-FDOPA-PET for Neurosurgical Planning and Radiotherapy Target Delineation in Glioma Patients: Biopsy Validation of 18F-FDOPA-PET Uptake and Biodistribution in Brain Tumors Active, not recruiting NCT01165632 Early Phase 1 fluorine F 18 fluorodopa
19 Correlation Between Psychological Stress and Progression of Newly Oligodendroglioma Towards Secondary Glioma: A Longitudinal Study Based on Long-term Follow-up Not yet recruiting NCT05536986
20 Dynamic Contrast Enhanced Steady State T1-Weighted Perfusion MRI (DCE MRI): Characterization of Intracranial Lesions Terminated NCT02967380 Gadobenate Dimeglumine;Gadobutrol
21 Assessment of Hypoxia in Malignant Gliomas Using EF5 Terminated NCT00430079 etanidazole
22 Yoga and Brain Cancer: A Feasibility Study Terminated NCT01234805
23 18F-FDOPA PET/CT or PET/MRI in Patients With Gliomas Terminated NCT02175745 18F-fluoro-dihydroxyphenylalanine
24 Efficacy of 68Ga-DOTATOC Positron Emission Tomography (PET) CT in Children and Young Adults With Brain Tumors Withdrawn NCT02194452

Search NIH Clinical Center for Adult Oligodendroglioma

Genetic Tests for Adult Oligodendroglioma

Anatomical Context for Adult Oligodendroglioma

Organs/tissues related to Adult Oligodendroglioma:

MalaCards : Brain, Liver

Publications for Adult Oligodendroglioma

Articles related to Adult Oligodendroglioma:

# Title Authors PMID Year
1
Prevalence of seizures in brain tumor: A meta-analysis. 62
36274423 2022
2
Rare occurrence of IDH2 mutation in adolescent oligodendroglioma with 1p/19q co-deletion: a case report. 62
32296936 2020
3
Pre- and post-surgery MRSI predictive value in adult oligodendroglioma prognosis. 62
29902567 2018
4
Outcomes and Prognostic Factors in Pediatric Oligodendroglioma: A Population-Based Study. 62
29131101 2018
5
Molecular characterization reveals NF1 deletions and FGFR1-activating mutations in a pediatric spinal oligodendroglioma. 62
27862886 2017
6
Mutation-specific IDH1 antibody differentiates oligodendrogliomas and oligoastrocytomas from other brain tumors with oligodendroglioma-like morphology. 62
21069360 2011

Variations for Adult Oligodendroglioma

Expression for Adult Oligodendroglioma

Search GEO for disease gene expression data for Adult Oligodendroglioma.

Pathways for Adult Oligodendroglioma

GO Terms for Adult Oligodendroglioma

Biological processes related to Adult Oligodendroglioma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nucleosome assembly GO:0006334 9.8 H3-3B H3-3A ATRX
2 2-oxoglutarate metabolic process GO:0006103 9.56 IDH2 IDH1
3 NADP metabolic process GO:0006739 9.46 IDH2 IDH1
4 isocitrate metabolic process GO:0006102 9.26 IDH2 IDH1
5 glyoxylate cycle GO:0006097 8.92 IDH2 IDH1

Molecular functions related to Adult Oligodendroglioma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 RNA polymerase II core promoter sequence-specific DNA binding GO:0000979 9.26 H3-3B H3-3A
2 isocitrate dehydrogenase (NADP+) activity GO:0004450 8.92 IDH2 IDH1

Sources for Adult Oligodendroglioma

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
Content
Loading form....