MCID: ADL008
MIFTS: 38

Adult Oligodendroglioma

Categories: Cancer diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Adult Oligodendroglioma

MalaCards integrated aliases for Adult Oligodendroglioma:

Name: Adult Oligodendroglioma 12 15
Adult Brain Oligodendroglioma 12 73
Grade Ii Adult Oligodendroglial Tumor 12
Oligodendroglioma, Adult 73

Classifications:



External Ids:

Disease Ontology 12 DOID:3186
MeSH 44 D009837
NCIt 50 C4014 C9376

Summaries for Adult Oligodendroglioma

MalaCards based summary : Adult Oligodendroglioma, also known as adult brain oligodendroglioma, is related to oligodendroglioma and interval angle-closure glaucoma, and has symptoms including headache and seizures. An important gene associated with Adult Oligodendroglioma is IDH2 (Isocitrate Dehydrogenase (NADP(+)) 2, Mitochondrial), and among its related pathways/superpathways are Citrate cycle (TCA cycle) and Peroxisome. The drugs Carmustine and Carboplatin have been mentioned in the context of this disorder. Affiliated tissues include brain, bone and bone marrow.

Related Diseases for Adult Oligodendroglioma

Diseases in the Oligodendroglioma family:

Adult Oligodendroglioma

Diseases related to Adult Oligodendroglioma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 39)
# Related Disease Score Top Affiliating Genes
1 oligodendroglioma 28.9 IDH1 IDH2
2 interval angle-closure glaucoma 9.8 IDH1 IDH2
3 enchondroma 9.8 IDH1 IDH2
4 intracranial chondrosarcoma 9.8 IDH1 IDH2
5 cytogenetically normal acute myeloid leukemia 9.8 IDH1 IDH2
6 chondroblastic osteosarcoma 9.8 IDH1 IDH2
7 intraductal papilloma 9.8 IDH1 IDH2
8 multiple enchondromatosis, maffucci type 9.8 IDH1 IDH2
9 spindle cell hemangioma 9.8 IDH1 IDH2
10 glioma susceptibility 1 9.8 IDH1 IDH2
11 periosteal chondrosarcoma 9.8 IDH1 IDH2
12 adult astrocytic tumour 9.8 IDH1 IDH2
13 fibrillary astrocytoma 9.8 IDH1 IDH2
14 undifferentiated pleomorphic sarcoma 9.8 IDH1 IDH2
15 drug-induced mental disorder 9.8 IDH1 IDH2
16 drug psychosis 9.8 IDH1 IDH2
17 diffuse infiltrative lymphocytosis syndrome 9.8 IDH1 IDH2
18 2-hydroxyglutaric aciduria 9.7 IDH1 IDH2
19 breast papillary carcinoma 9.7 IDH1 IDH2
20 d-2-hydroxyglutaric aciduria 1 9.7 IDH1 IDH2
21 bone marrow cancer 9.7 FGFR1 NF1
22 enchondromatosis, multiple, ollier type 9.7 IDH1 IDH2
23 bile duct adenocarcinoma 9.7 IDH1 IDH2
24 intrahepatic cholangiocarcinoma 9.6 IDH1 IDH2
25 li-fraumeni syndrome 9.6 IDH1 NF1
26 chondrosarcoma 9.6 IDH1 IDH2
27 giant cell glioblastoma 9.5 FGFR1 IDH1
28 gliosarcoma 9.5 FGFR1 IDH1
29 essential thrombocythemia 9.4 IDH1 IDH2
30 bladder urothelial carcinoma 9.4 FGFR1 IDH1
31 myelofibrosis 9.3 IDH1 IDH2
32 pilocytic astrocytoma of cerebellum 9.2 IDH1 IDH2 NF1
33 myeloma, multiple 9.2 IDH1 IDH2
34 brain stem glioma 9.1 FGFR1 IDH1 IDH2
35 pilocytic astrocytoma 9.1 FGFR1 IDH1 NF1
36 myelodysplastic syndrome 9.1 IDH1 IDH2 NF1
37 glioblastoma 9.0 FGFR1 IDH1 IDH2
38 glioma 8.5 FGFR1 IDH1 IDH2 NF1
39 hepatocellular carcinoma 8.3 FGFR1 IDH1 IDH2

Graphical network of the top 20 diseases related to Adult Oligodendroglioma:



Diseases related to Adult Oligodendroglioma

Symptoms & Phenotypes for Adult Oligodendroglioma

UMLS symptoms related to Adult Oligodendroglioma:


headache, seizures

Drugs & Therapeutics for Adult Oligodendroglioma

Drugs for Adult Oligodendroglioma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 360)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Carmustine Approved, Investigational Phase 3,Phase 1,Phase 2,Not Applicable 154-93-8 2578
2
Carboplatin Approved Phase 3,Phase 2,Phase 1,Not Applicable 41575-94-4 10339178 498142 38904
3
Vincristine Approved, Investigational Phase 3,Phase 2,Phase 1,Not Applicable 2068-78-2, 57-22-7 5978
4
Cisplatin Approved Phase 3,Phase 2,Phase 1 15663-27-1 84093 441203 2767
5
Cyclophosphamide Approved, Investigational Phase 3,Phase 2,Phase 1 50-18-0, 6055-19-2 2907
6
Etoposide Approved Phase 3,Phase 2,Phase 1,Not Applicable 33419-42-0 36462
7
Lenograstim Approved, Investigational Phase 3,Phase 2,Phase 1 135968-09-1
8
Methotrexate Approved Phase 3,Phase 2,Not Applicable 1959-05-2, 59-05-2 126941
9
Temozolomide Approved, Investigational Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 85622-93-1 5394
10
Thiotepa Approved, Investigational Phase 3,Phase 2,Phase 1 52-24-4 5453
11
Dacarbazine Approved, Investigational Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 4342-03-4 5351166
12
Lomustine Approved, Investigational Phase 3,Phase 2,Phase 1 13010-47-4 3950
13
Procarbazine Approved, Investigational Phase 3,Phase 2,Phase 1 671-16-9 4915
14
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 3 437-38-7 3345
15
Donepezil Approved Phase 3,Phase 2 120014-06-4 3152
16
Dexamethasone Approved, Investigational, Vet_approved Phase 3,Phase 2,Phase 1 50-02-2 5743
17
Granisetron Approved, Investigational Phase 3 109889-09-0 3510
18
Ondansetron Approved Phase 3 99614-02-5 4595
19
Cyproheptadine Approved Phase 3,Phase 2 129-03-3 2913
20
Histamine Approved, Investigational Phase 3,Phase 2 75614-87-8, 51-45-6 774
21
Dopamine Approved Phase 3,Not Applicable 51-61-6, 62-31-7 681
22
Methylphenidate Approved, Investigational Phase 3 113-45-1 4158
23
Isotretinoin Approved Phase 3,Phase 1 4759-48-2 5538 5282379
24
Folic Acid Approved, Nutraceutical, Vet_approved Phase 3,Phase 2,Phase 1,Not Applicable 59-30-3 6037
25
leucovorin Approved, Nutraceutical Phase 3,Phase 2,Phase 1,Not Applicable 58-05-9 143 6006
26
Tretinoin Approved, Investigational, Nutraceutical Phase 3,Phase 1 302-79-4 5538 444795
27 Pancreatic Polypeptide Investigational Phase 3,Phase 1 59763-91-6
28 Alkylating Agents Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
29 Antineoplastic Agents, Alkylating Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
30 Antimitotic Agents Phase 3,Phase 2,Phase 1,Not Applicable
31 Antineoplastic Agents, Phytogenic Phase 3,Phase 2,Phase 1,Not Applicable
32 Antimetabolites Phase 3,Phase 2,Phase 1,Not Applicable
33 Antimetabolites, Antineoplastic Phase 3,Phase 2,Not Applicable
34 Antirheumatic Agents Phase 3,Phase 2,Phase 1,Not Applicable
35 Dermatologic Agents Phase 3,Phase 1,Phase 2,Not Applicable
36 Etoposide phosphate Phase 3,Phase 2,Phase 1,Not Applicable
37 Folic Acid Antagonists Phase 3,Phase 2,Not Applicable
38 Immunosuppressive Agents Phase 3,Phase 2,Phase 1,Not Applicable
39 Nucleic Acid Synthesis Inhibitors Phase 3,Phase 2,Phase 1,Not Applicable
40 Topoisomerase Inhibitors Phase 3,Phase 2,Phase 1,Not Applicable
41 Vitamin B Complex Phase 3,Phase 2,Phase 1,Not Applicable
42 Central Nervous System Depressants Phase 3,Phase 1,Phase 2
43 Liver Extracts Phase 3,Phase 2,Phase 1
44 Keratolytic Agents Phase 3,Phase 1,Phase 2
45 Adjuvants, Anesthesia Phase 3
46 Analgesics Phase 3,Phase 2,Phase 1
47 Analgesics, Opioid Phase 3
48 Anesthetics Phase 3,Phase 1
49 Anesthetics, General Phase 3
50 Anesthetics, Intravenous Phase 3

Interventional clinical trials:

(show top 50) (show all 366)
# Name Status NCT ID Phase Drugs
1 Safety and Efficacy Study of Intracranially Implanted Carmustine to Treat Newly Diagnosed Malignant Glioma Unknown status NCT01656980 Phase 3 Carmustine
2 Carboplatin Plus Vincristine in Treating Children and Adolescents With Low Grade Glioma Unknown status NCT00003015 Phase 3 carboplatin;vincristine sulfate
3 Combination Chemotherapy With or Without Etoposide Followed By an Autologous Stem Cell Transplant in Treating Young Patients With Previously Untreated Malignant Brain Tumors Unknown status NCT00392886 Phase 3 carboplatin;cisplatin;cyclophosphamide;etoposide;methotrexate;temozolomide;thiotepa;vincristine sulfate
4 Radiation Therapy With and Without Combination Chemotherapy in Patients With Resected Anaplastic Oligodendroglioma Completed NCT00002840 Phase 3 lomustine;procarbazine hydrochloride;vincristine sulfate
5 Radiation Therapy With or Without Chemotherapy in Treating Patients With Anaplastic Oligodendroglioma Completed NCT00002569 Phase 3 lomustine;procarbazine hydrochloride;vincristine sulfate
6 Randomized Phase III Study of Sequential Radiochemotherapy of Anaplastic Glioma With PCV or Temozolomide Completed NCT00717210 Phase 3 Temozolomide
7 Radiation Therapy or Temozolomide in Treating Patients With Gliomas Completed NCT00182819 Phase 3 temozolomide
8 Observation or Radiation Therapy With or Without Combination Chemotherapy in Treating Patients With Low-Grade Glioma Completed NCT00003375 Phase 2, Phase 3 lomustine;procarbazine hydrochloride;vincristine sulfate
9 Fentanyl Sublingual Spray in Treating Patients With Breakthrough Cancer Pain Completed NCT00538850 Phase 3 Fentanyl sublingual spray;Placebo
10 Donepezil in Treating Patients Who Have Undergone Radiation Therapy for Brain Tumors Completed NCT00369785 Phase 3 donepezil hydrochloride;Placebo
11 Acupressure in Controlling Nausea in Young Patients Receiving Highly Emetogenic Chemotherapy Completed NCT01346267 Phase 3
12 Efficacy of Post-radiation Adjuvant Temozolomide Chemotherapy in Residue Low-grade Glioma Recruiting NCT01649830 Phase 3 Temozolomide
13 Radiation Therapy With Concomitant and Adjuvant Temozolomide Versus Radiation Therapy With Adjuvant PCV Chemotherapy in Patients With Anaplastic Glioma or Low Grade Glioma Recruiting NCT00887146 Phase 3 concomitant temozolomide (TMZ);procarbazine;adjuvant temozolomide (TMZ);CCNU;vincristine
14 Phase III Trial of Anaplastic Glioma Without 1p/19q LOH Active, not recruiting NCT00626990 Phase 3 temozolomide
15 Radiation Therapy With or Without Temozolomide in Treating Patients With Low-Grade Glioma Active, not recruiting NCT00978458 Phase 3 temozolomide
16 Treatment Strategy for Low-grade Gliomas Terminated NCT00897377 Phase 3 Temozolomide
17 Cyproheptadine in Preventing Weight Loss in Children Receiving Chemotherapy for Cancer Terminated NCT01132547 Phase 3 cyproheptadine hydrochloride
18 Methylphenidate to Improve Quality of Life in Patients Undergoing Radiation Therapy for Brain Tumors Terminated NCT00031798 Phase 3 methylphenidate hydrochloride
19 Procarbazine and Isotretinoin in Treating Patients With Recurrent Primary Malignant Gliomas Withdrawn NCT00003564 Phase 3 Isotretinoin;Procarbazine Hydrochloride
20 Phase I/II Trial of Safety and Anti-tumor Efficacy of AXL1717(Picropodophyllin) in the Treatment of Recurrent Malignant Astrocytomas Unknown status NCT01721577 Phase 1, Phase 2 AXL1717
21 A Prospective Cohort to Study the Effect of Temozolomide on IDH Mutational Low Grade Gliomas Unknown status NCT02209428 Phase 2 Temozolomide
22 A Study of 131I-TM601 in Adults With Recurrent Malignant Glioma Unknown status NCT00683761 Phase 1, Phase 2 131I-TM601
23 Temozolomide in Treating Patients With Recurrent or Progressive Malignant Glioma Unknown status NCT00004204 Phase 2 temozolomide
24 Proton Beam Radiation Therapy in Treating Patients With Low Grade Gliomas Unknown status NCT01024907 Phase 1, Phase 2
25 A Study of Aminolevulinic Acid (ALA) to Enhance Visualization and Resection of Malignant Glial Tumors of the Brain Unknown status NCT01403311 Phase 2 5-Aminolevuline Acid
26 Cisplatin and Temozolomide in Treating Young Patients With Malignant Glioma Unknown status NCT00360945 Phase 2 cisplatin;temozolomide
27 Combination Chemotherapy With or Without Radiation Therapy in Treating Children With Brain Tumors Unknown status NCT00281905 Phase 2 carboplatin;cisplatin;cyclophosphamide;methotrexate;vincristine sulfate
28 Carmustine Followed By Surgery in Treating Patients With Recurrent Supratentorial Malignant Glioma or Metastatic Brain Neoplasm Unknown status NCT00009854 Phase 1, Phase 2 carmustine in ethanol
29 Temozolomide in Relapsed or Advanced Anaplastic Oligodendroglioma and Oligoastrocytoma: Single-arm, Phase II Trial Completed NCT01847235 Phase 2 Temozolomide
30 Temozolomide in Patients With Newly Diagnosed Anaplastic Oligodendroglioma and Mixed Oligoastrocytoma Completed NCT00362570 Phase 2 Temozolomide
31 Combination Chemotherapy and Bone Marrow Transplantation or Peripheral Stem Cell Transplantation in Treating Patients With Oligodendroglioma Completed NCT00003101 Phase 2 busulfan;lomustine;procarbazine hydrochloride;thiotepa;vincristine sulfate
32 Temozolomide in Treating Patients With Newly Diagnosed Anaplastic Oligodendroglioma or Mixed Oligoastrocytoma Completed NCT00400816 Phase 2 temozolomide
33 Temozolomide in Treating Patients With Anaplastic Oligodendroglioma Completed NCT00003465 Phase 2 temozolomide
34 Temozolomide Plus Radiation Therapy in Treating Patients With Newly Diagnosed Anaplastic Oligodendrogliomas or Mixed Anaplastic Oligoastrocytomas Completed NCT00033280 Phase 2 temozolomide
35 Biological Therapy Following Surgery and Radiation Therapy in Treating Patients With Primary or Recurrent Astrocytoma or Oligodendroglioma Completed NCT00004024 Phase 2
36 Topotecan in Treating Patients With Recurrent Brain Tumors Completed NCT00003372 Phase 2 topotecan hydrochloride
37 Phase II NKTR-102 In Bevacizumab-Resistant High Grade Glioma Completed NCT01663012 Phase 2 Etirinotecan pegol
38 Thiotepa Followed by Peripheral Stem Cell or Bone Marrow Transplant in Treating Patients With Malignant Glioma Completed NCT00008008 Phase 2 cyclophosphamide;thiotepa
39 Temozolomide in Treating Patients With Recurrent Oligodendroglial Tumors Completed NCT00003304 Phase 2 temozolomide
40 Prolonged Daily Temozolomide for Low-Grade Glioma Completed NCT00165360 Phase 2 Temozolomide
41 Phase II Trial of RAD001 in Patients With Recurrent Low Grade Glioma Completed NCT00823459 Phase 2 RAD001
42 Phase II Imatinib + Hydroxyurea in Treatment of Patients With Recurrent/Progressive Grade II Low-Grade Glioma (LGG) Completed NCT00615927 Phase 2 Imatinib Mesylate & Hydroxyurea
43 Temozolomide in Treating Patients With Recurrent Oligodendroglial Tumors Completed NCT00003731 Phase 2 temozolomide
44 Tandutinib Plus Bevacizumab to Treat Recurrent Brain Tumors Completed NCT00667394 Phase 2 MLN-518 (Tandutinib)
45 Chemotherapy in Treating Patients With Progressive or Recurrent Brain Tumors Completed NCT00012038 Phase 1, Phase 2 irofulven
46 Procarbazine in Treating Patients With Recurrent Brain Tumor Completed NCT00004004 Phase 1, Phase 2 procarbazine hydrochloride
47 Efficacy of Protracted Temozolomide in Patients With Progressive High Grade Glioma Completed NCT00575887 Phase 2 Temozolomide
48 The Effects of Continuous 28-day (28/28) Temozolomide Chemotherapy in Subjects With Recurrent Malignant Glioma Who Have Failed the Conventional 5-day (5/28) Treatment (P04601) Completed NCT00392171 Phase 2 Temozolomide
49 Phase II Study of Carmustine, Streptozocin, and Mercaptopurine for Refractory or Recurrent Brain Neoplasms Completed NCT00004688 Phase 2 carmustine;mercaptopurine;streptozocin
50 A Proof-of-concept Study to Assess the Ability of [18F]AH-111585 PET Imaging to Detect Tumours and Angiogenesis Completed NCT00565721 Phase 2 Fluciclatide Injection - (AH111585 (F18))

Search NIH Clinical Center for Adult Oligodendroglioma

Genetic Tests for Adult Oligodendroglioma

Anatomical Context for Adult Oligodendroglioma

MalaCards organs/tissues related to Adult Oligodendroglioma:

41
Brain, Bone, Bone Marrow, Spinal Cord, T Cells, Liver, Endothelial

Publications for Adult Oligodendroglioma

Articles related to Adult Oligodendroglioma:

# Title Authors Year
1
Pre- and post-surgery MRSI predictive value in adult oligodendroglioma prognosis. ( 29902567 )
2018

Variations for Adult Oligodendroglioma

Expression for Adult Oligodendroglioma

Search GEO for disease gene expression data for Adult Oligodendroglioma.

Pathways for Adult Oligodendroglioma

Pathways related to Adult Oligodendroglioma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.27 IDH1 IDH2
2 11.07 IDH1 IDH2
3 10.77 FGFR1 IDH1
4
Show member pathways
9.74 IDH1 IDH2

GO Terms for Adult Oligodendroglioma

Cellular components related to Adult Oligodendroglioma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 peroxisome GO:0005777 8.62 IDH1 IDH2

Biological processes related to Adult Oligodendroglioma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 tricarboxylic acid cycle GO:0006099 9.26 IDH1 IDH2
2 2-oxoglutarate metabolic process GO:0006103 9.16 IDH1 IDH2
3 isocitrate metabolic process GO:0006102 8.96 IDH1 IDH2
4 glyoxylate cycle GO:0006097 8.62 IDH1 IDH2

Molecular functions related to Adult Oligodendroglioma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 magnesium ion binding GO:0000287 9.32 IDH1 IDH2
2 NAD binding GO:0051287 9.26 IDH1 IDH2
3 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GO:0016616 9.16 IDH1 IDH2
4 isocitrate dehydrogenase activity GO:0004448 8.96 IDH1 IDH2
5 isocitrate dehydrogenase (NADP+) activity GO:0004450 8.62 IDH1 IDH2

Sources for Adult Oligodendroglioma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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