MCID: ADL008
MIFTS: 40

Adult Oligodendroglioma

Categories: Cancer diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Adult Oligodendroglioma

MalaCards integrated aliases for Adult Oligodendroglioma:

Name: Adult Oligodendroglioma 12 15
Adult Brain Oligodendroglioma 12 72
Grade Ii Adult Oligodendroglial Tumor 12
Oligodendroglioma, Adult 72

Classifications:



External Ids:

Disease Ontology 12 DOID:3186
MeSH 44 D009837
NCIt 50 C4014 C9376
UMLS 72 C0279070 C1332190

Summaries for Adult Oligodendroglioma

MalaCards based summary : Adult Oligodendroglioma, also known as adult brain oligodendroglioma, is related to oligodendroglioma and interval angle-closure glaucoma, and has symptoms including seizures and headache. An important gene associated with Adult Oligodendroglioma is IDH1 (Isocitrate Dehydrogenase (NADP(+)) 1), and among its related pathways/superpathways are MAPK signaling pathway and Glioma. The drugs Donepezil and Fentanyl have been mentioned in the context of this disorder. Affiliated tissues include brain, t cells and liver, and related phenotypes are growth/size/body region and cardiovascular system

Related Diseases for Adult Oligodendroglioma

Diseases in the Oligodendroglioma family:

Adult Oligodendroglioma

Diseases related to Adult Oligodendroglioma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 101)
# Related Disease Score Top Affiliating Genes
1 oligodendroglioma 27.2 TP53 PDGFRA OLIG2 IDH2 IDH1 GFAP
2 interval angle-closure glaucoma 10.6 IDH2 IDH1
3 enchondroma 10.6 IDH2 IDH1
4 cytogenetically normal acute myeloid leukemia 10.6 IDH2 IDH1
5 chondroblastic osteosarcoma 10.6 IDH2 IDH1
6 intraductal papilloma 10.6 IDH2 IDH1
7 multiple enchondromatosis, maffucci type 10.6 IDH2 IDH1
8 spindle cell hemangioma 10.6 IDH2 IDH1
9 extraventricular neurocytoma 10.6 IDH1 GFAP
10 periosteal chondrosarcoma 10.6 IDH2 IDH1
11 primary hypereosinophilic syndrome 10.6 PDGFRA FGFR1
12 oligoastrocytoma 10.5 IDH2 GFAP
13 myeloid and lymphoid neoplasms with eosinophilia and abnormalities of pdgfra, pdgfrb, and fgfr1 10.5 PDGFRA FGFR1
14 dysembryoplastic neuroepithelial tumor 10.5 IDH1 GFAP
15 gemistocytic astrocytoma 10.5 IDH2 GFAP
16 adult astrocytic tumour 10.5 IDH2 IDH1
17 anaplastic oligodendroglioma 10.5 IDH2 GFAP
18 diffuse infiltrative lymphocytosis syndrome 10.5 IDH2 IDH1
19 angiocentric glioma 10.5 IDH1 GFAP
20 drug psychosis 10.5 IDH2 IDH1
21 drug-induced mental disorder 10.5 IDH2 IDH1
22 chronic eosinophilic leukemia 10.4 PDGFRA FGFR1
23 frontal convexity meningioma 10.4 TP53 GFAP
24 plexiform schwannoma 10.4 NF1 GFAP
25 cerebral convexity meningioma 10.4 TP53 GFAP
26 periosteal osteogenic sarcoma 10.4 TP53 IDH1
27 cellular ependymoma 10.4 TP53 GFAP
28 meninges sarcoma 10.4 TP53 GFAP
29 central nervous system primitive neuroectodermal neoplasm 10.4 TP53 GFAP
30 atypical neurofibroma 10.4 NF1 GFAP
31 spinal cancer 10.4 TP53 GFAP
32 megaesophagus 10.4 TP53 FGFR1
33 cerebral neuroblastoma 10.4 TP53 GFAP
34 obstructive hydrocephalus 10.4 NF1 GFAP
35 ependymoblastoma 10.3 TP53 GFAP
36 neurilemmoma of the fifth cranial nerve 10.3 NF1 GFAP
37 undifferentiated pleomorphic sarcoma 10.3 PDGFRA IDH2 IDH1
38 trigeminal nerve neoplasm 10.3 NF1 GFAP
39 chordoid glioma 10.3 TP53 GFAP
40 cerebral ventricle cancer 10.3 TP53 GFAP
41 2-hydroxyglutaric aciduria 10.3 IDH2 IDH1
42 malignant ependymoma 10.3 TP53 GFAP
43 cerebellopontine angle tumor 10.3 IDH1 GFAP
44 cerebellar astrocytoma 10.3 TP53 KIAA1549 IDH1
45 neurofibromatosis, type i 10.2 PDGFRA NF1
46 intracranial chondrosarcoma 10.2 TP53 IDH2 IDH1
47 papilloma of choroid plexus 10.2 TP53 GFAP
48 bile duct adenocarcinoma 10.2 TP53 IDH2 IDH1
49 choroid plexus cancer 10.2 TP53 GFAP
50 intrahepatic cholangiocarcinoma 10.2 TP53 IDH2 IDH1

Graphical network of the top 20 diseases related to Adult Oligodendroglioma:



Diseases related to Adult Oligodendroglioma

Symptoms & Phenotypes for Adult Oligodendroglioma

UMLS symptoms related to Adult Oligodendroglioma:


seizures, headache

MGI Mouse Phenotypes related to Adult Oligodendroglioma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 9.92 FGFR1 FUBP1 GFAP IDH1 NF1 OLIG2
2 cardiovascular system MP:0005385 9.91 FGFR1 FUBP1 GFAP IDH2 NF1 PDGFRA
3 immune system MP:0005387 9.86 FGFR1 FUBP1 GFAP IDH1 KIAA1549 NF1
4 muscle MP:0005369 9.63 FGFR1 GFAP NF1 OLIG2 PDGFRA TP53
5 neoplasm MP:0002006 9.35 IDH2 NF1 OLIG2 PDGFRA TP53
6 respiratory system MP:0005388 9.1 FUBP1 IDH1 NF1 OLIG2 PDGFRA TP53

Drugs & Therapeutics for Adult Oligodendroglioma

Drugs for Adult Oligodendroglioma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 235)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Donepezil Approved Phase 3 120014-06-4 3152
2
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 3 437-38-7 3345
3
Lomustine Approved, Investigational Phase 3 13010-47-4 3950
4
Vincristine Approved, Investigational Phase 3 57-22-7, 2068-78-2 5978
5
Temozolomide Approved, Investigational Phase 3 85622-93-1 5394
6
Dopamine Approved Phase 3 51-61-6, 62-31-7 681
7
Methylphenidate Approved, Investigational Phase 3 113-45-1 4158
8 Pancreatic Polypeptide Investigational Phase 3 59763-91-6
9 Analgesics Phase 3
10 Central Nervous System Depressants Phase 3
11 Nootropic Agents Phase 3
12 Peripheral Nervous System Agents Phase 3
13 Liver Extracts Phase 3
14 Cholinesterase Inhibitors Phase 3
15 Cholinergic Agents Phase 3
16 Cola Phase 3
17 Anesthetics, Intravenous Phase 3
18 Narcotics Phase 3
19 Analgesics, Opioid Phase 3
20 Adjuvants, Anesthesia Phase 3
21 Anesthetics, General Phase 3
22 Anesthetics Phase 3
23 Antineoplastic Agents, Phytogenic Phase 3
24 Tubulin Modulators Phase 3
25 Antimitotic Agents Phase 3
26 Alkylating Agents Phase 3
27 Antineoplastic Agents, Alkylating Phase 3
28 Central Nervous System Stimulants Phase 3
29 Neurotransmitter Agents Phase 3
30 Dexmethylphenidate Hydrochloride Phase 3
31 Neurotransmitter Uptake Inhibitors Phase 3
32 Dopamine Uptake Inhibitors Phase 3
33 Dopamine Agents Phase 3
34
Dasatinib Approved, Investigational Phase 2 302962-49-8 3062316
35
Ethanol Approved Phase 1, Phase 2 64-17-5 702
36
Pregabalin Approved, Illicit, Investigational Phase 2 148553-50-8 5486971
37
Levetiracetam Approved, Investigational Phase 2 102767-28-2 441341
38
Cisplatin Approved Phase 2 15663-27-1 84093 441203 2767
39
Tamoxifen Approved Phase 2 10540-29-1 2733526
40
Sodium citrate Approved, Investigational Phase 2 68-04-2
41
Doxorubicin Approved, Investigational Phase 2 23214-92-8 31703
42
Modafinil Approved, Investigational Phase 2 68693-11-8 4236
43
Aldesleukin Approved Phase 2 85898-30-2, 110942-02-4
44
Thiotepa Approved, Investigational Phase 2 52-24-4 5453
45
Busulfan Approved, Investigational Phase 2 55-98-1 2478
46
Irinotecan Approved, Investigational Phase 2 100286-90-6, 97682-44-5 60838
47
Bevacizumab Approved, Investigational Phase 2 216974-75-3
48
Cyclophosphamide Approved, Investigational Phase 2 50-18-0, 6055-19-2 2907
49
Carmustine Approved, Investigational Phase 2 154-93-8 2578
50
Topotecan Approved, Investigational Phase 2 123948-87-8, 119413-54-6 60700

Interventional clinical trials:

(show top 50) (show all 134)
# Name Status NCT ID Phase Drugs
1 Phase III Double Blind, Placebo Controlled Study of Donepezil in the Irradiated Brain Completed NCT00369785 Phase 3 donepezil hydrochloride;Placebo
2 Primary Chemotherapy With Temozolomide Versus Radiotherapy in Patients With Low Grade Gliomas After Stratification for Genetic 1p Loss: A Phase III Study Completed NCT00182819 Phase 3 temozolomide
3 A Phase II Study of Observation in Favorable Low-Grade Glioma and a Phase II Study of Radiation With or Without PCV Chemotherapy in Unfavorable Low-Grade Glioma Completed NCT00003375 Phase 2, Phase 3 lomustine;procarbazine hydrochloride;vincristine sulfate
4 A Randomized, Double-blind, Placebo-controlled Multi-center Study to Evaluate the Safety and Efficacy of Fentanyl Sublingual Spray (Fentanyl SL Spray) for the Treatment of Breakthrough Cancer Pain Completed NCT00538850 Phase 3 Fentanyl sublingual spray;Placebo
5 Phase III Intergroup Randomized Comparison of Radiation Alone vs. Pre-Radiation Chemotherapy for Pure and Mixed Anaplastic Oligodendrogliomas Completed NCT00002569 Phase 3 lomustine;procarbazine hydrochloride;vincristine sulfate
6 PHASE III STUDY OF ADJUVANT PROCARBAZINE, CCNU AND VINCRISTINE CHEMOTHERAPY IN PATIENTS WITH HIGHLY ANAPLASTIC OLIGODENDROGLIOMA Completed NCT00002840 Phase 3 lomustine;procarbazine hydrochloride;vincristine sulfate
7 Phase III Intergroup Study of Radiotherapy With Concomitant and Adjuvant Temozolomide Versus Radiotherapy With Adjuvant PCV Chemotherapy in Patients With 1p/19q Co-deleted Anaplastic Glioma or Low Grade Glioma Recruiting NCT00887146 Phase 3 concomitant temozolomide (TMZ);procarbazine;adjuvant temozolomide (TMZ);CCNU;vincristine
8 Phase III Study of Radiation Therapy With or Without Temozolomide for Symptomatic or Progressive Low-Grade Gliomas Active, not recruiting NCT00978458 Phase 3 temozolomide
9 Phase III Trial on Concurrent and Adjuvant Temozolomide Chemotherapy in Non-1p/19q Deleted Anaplastic Glioma. The CATNON Intergroup Trial. Active, not recruiting NCT00626990 Phase 3 temozolomide
10 A Phase III, Double-Blind, Prospective Randomized Clinical Trial of the Effect of D-threo-methylphenidate HCl (d-MPH) on Quality of Life in Brain Tumor Patients Receiving Radiation Therapy Terminated NCT00031798 Phase 3 methylphenidate hydrochloride
11 Phase III Randomized Evaluation of 13-Cis-Retinoic Acid (cRA) Plus Procarbazine Versus Procarbazine Alone in the Treatment of Patients With Recurrent Primary Malignant Gliomas Withdrawn NCT00003564 Phase 3 Isotretinoin;Procarbazine Hydrochloride
12 Phase I/Randomized Phase II Double Blind Study of Either Dasatinib or Placebo Combined With Bevacizumab in Recurrent Glioblastoma Unknown status NCT00892177 Phase 2 dasatinib
13 Phase I/II Study of Intratumoral Injection of DTI-015 Prior to Tumor Resection in Patients With Recurrent Malignant Glioma or Metastatic Neoplasm to Brain Unknown status NCT00009854 Phase 1, Phase 2 carmustine in ethanol
14 A Phase II Trial of Continuous Low-Dose Temozolomide for Patients With Recurrent Malignant Glioma Completed NCT00498927 Phase 2 temozolomide
15 Levetiracetam and Pregabalin for Monotherapy in Patients With Brain Tumors and Seizures. A Phase II Randomized Study. Completed NCT00629889 Phase 2 levetiracetam;pregabalin
16 Improved Characterization of Brain Tumors By MRI and MRS Completed NCT00274755 Phase 2 chemotherapy
17 PHASE I STUDY OF ANTI-TENASCIN MONOCLONAL ANTIBODY 131I 81C6 VIA SURGICALLY CREATED CYSTIC RESECTION CAVITY IN THE TREATMENT OF PATIENTS WITH PRIMARY OR METASTATIC MALIGNANT BRAIN TUMORS Completed NCT00002752 Phase 1, Phase 2
18 Cisplatin, Doxorubicin and Tamoxifen in the Treatment of Incurable Soft Tissue and Endocrine Malignancies Completed NCT00002608 Phase 2 cisplatin;doxorubicin hydrochloride;tamoxifen citrate
19 A Phase II Study of Temozolomide (TEMODAR) in the Treatment of Adult Patients With Supratentorial Low Grade Glioma Completed NCT00313729 Phase 2 temozolomide
20 First Line Chemotherapy With Temozolomide in Recurrent Oligodendroglial Tumors, a Phase II Trial Completed NCT00003731 Phase 2 temozolomide
21 Phase II Treatment of Adults and Children With Progressive Low Grade Gliomas With Temodal Completed NCT00003466 Phase 2 temozolomide
22 A Feasibility Study of Armodafinil for Brain Radiation-Induced Fatigue Completed NCT01032200 Phase 2 Armodafinil
23 Phase I/II Trial of Pyrazoloacridine and Carboplatin in Patients With Recurrent Glioma Completed NCT00005976 Phase 2 carboplatin;pyrazoloacridine
24 Immunotherapy for Malignant Glioma - Phase II Trial of Autologous Cancer Antigen Specific Immunotherapy Completed NCT00004024 Phase 2
25 Donepezil and EGb761 in Improving Neurocognitive Function in Patients Who Have Previously Undergone Radiation Therapy for Primary Brain Tumor or Brain Metastases Completed NCT00070161 Phase 2 donepezil hydrochloride
26 A Phase II Trial of Intensive Chemotherapy and Autotransplantation for Patients With Newly Diagnosed Anaplastic Oligodendroglioma Completed NCT00003101 Phase 2 busulfan;lomustine;procarbazine hydrochloride;thiotepa;vincristine sulfate
27 A Phase II Trial of Irinotecan in Recurrent Glioma Completed NCT00003134 Phase 2 irinotecan hydrochloride
28 CAMP 013:- Tandem Thiotepa Regimen For Selected Malignant Gliomas:1) Primary Or Recurrent Glioblastoma Multiforme (GBM); and 2) Recurrent Anaplastic Astrocytomas (AA), Oligodendrogliomas (O), Oligoastrocytomas (OA), Ependymomas And Primitive Neuroectodermal Tumors (PNET) That Have Either Progressed After Primary Therapy Or Are Refractory To Standard Chemotherapy Completed NCT00008008 Phase 2 cyclophosphamide;thiotepa
29 Phase I/II Trial of Irinotecan (CPT-11) in Patients With Recurrent Malignant Glioma Completed NCT00003616 Phase 1, Phase 2 irinotecan hydrochloride
30 A Pilot Study of Tamoxifen, Carboplatin and Topotecan in the Treatment of Recurrent or Refractory Primary Brain or Spinal Cord Tumors or Metastatic Epithelial Cancers With Central Nervous System Metastases Completed NCT00541138 Phase 2 carboplatin;tamoxifen citrate;topotecan hydrochloride
31 Randomized Trial Assessing the Significance of Bevacizumab in Recurrent Grade II and Grade III Gliomas - The TAVAREC Trial Completed NCT01164189 Phase 2 Temozolomide
32 Phase II Study of Carmustine, Streptozocin, and Mercaptopurine for Refractory or Recurrent Brain Neoplasms Completed NCT00004688 Phase 2 carmustine;mercaptopurine;streptozocin
33 Phase II Trial of Continuous Dose Temozolomide in Patients With Newly Diagnosed Pure and Mixed Anaplastic Oligodendroglioma Completed NCT00400816 Phase 2 temozolomide
34 A Phase II Trial Of Pre-Irradiation And Concurrent Temozolomide In Patients With Newly Diagnosed Anaplastic Oligodendrogliomas And Mixed Anaplastic Oligoastrocytomas Completed NCT00033280 Phase 2 temozolomide
35 Bevacizumab in Combination With Irinotecan for Malignant Gliomas Completed NCT00268359 Phase 2 irinotecan hydrochloride
36 Open Label Phase II Study On STI571 (Glivec) Administered As A Daily Oral Treatment In Gliomas Completed NCT00039364 Phase 2 imatinib mesylate
37 A Phase II Study of Temozolomide (SCH 52365, Temodal(R)) for the Treatment of Recurrent Malignant Glioma Completed NCT00004113 Phase 2 temozolomide
38 A Multi-Center, Open-Label Clinical Study to Evaluate the Safety and Performance of the Proxima GliaSite RTS, a Radiation Delivery System, in Patients With Recurrent Malignant Brain Tumors Undergoing Surgical Resection Completed NCT00003574 Phase 2
39 Phase II Treatment of Adults With Recurrent Supratentorial Low Grade Glioma With Gliadel Wafers Completed NCT00003467 Phase 2 carmustine;polifeprosan 20 with carmustine implant
40 A Phase II Study of Topotecan in Patients With Anaplastic Oligodendroglioma or Anaplastic Mixed Oligoastrocytoma Completed NCT00003372 Phase 2 topotecan hydrochloride
41 Second Line Chemotherapy With Temozolomide in Recurrent Oligodendroglial Tumors After PCV-Chemotherapy Completed NCT00003304 Phase 2 temozolomide
42 PHASE II STUDY OF CARBOPLATIN (CBDCA) IN THE TREATMENT OF CHILDREN AND ADULTS WITH PROGRESSIVE LOW GRADE GLIOMAS Completed NCT00002749 Phase 2 carboplatin
43 ANALYSIS OF THE EFFICACY OF SURAMIN IN RECURRENT MALIGNANT PRIMARY BRAIN TUMORS Completed NCT00002639 Phase 2 chemotherapy;suramin
44 A Phase I/II Trial of EMD 121974 for Treatment of Patients With Recurrent Anaplastic Gliomas Completed NCT00006093 Phase 1, Phase 2 cilengitide
45 Phase II Evaluation of Fenretinide NSC (374551) as a Single Agent in the Treatment of Adult Patients With Recurrent Malignant Glioma Completed NCT00006080 Phase 2 fenretinide
46 A Phase II Trial Of Thalidomide And Procarbazine In Adults With Recurrent/Progressive Gliomas Completed NCT00079092 Phase 2 procarbazine hydrochloride;thalidomide
47 A Phase I/II Study of Oral Procarbazine in the Treatment of Recurrent High Grade Astrocytomas Completed NCT00004004 Phase 1, Phase 2 procarbazine hydrochloride
48 A Phase II Trial Of Talampanel In Patients With Recurrent High-Grade Gliomas Completed NCT00064363 Phase 2 talampanel
49 Trial Of Oral Thalidomide, Celecoxib, Etoposide And Cyclophosphamide In Adult Patients With Relapsed Or Progressive Malignant Gliomas Completed NCT00047281 Phase 2 celecoxib;cyclophosphamide;etoposide;thalidomide
50 Phase II Study of 7 Days On/7 Days Off Temozolomide in Patients With High-Grade Glioma Completed NCT00619112 Phase 2 temozolomide

Search NIH Clinical Center for Adult Oligodendroglioma

Genetic Tests for Adult Oligodendroglioma

Anatomical Context for Adult Oligodendroglioma

MalaCards organs/tissues related to Adult Oligodendroglioma:

41
Brain, T Cells, Liver, Skin, Bone, Spinal Cord

Publications for Adult Oligodendroglioma

Articles related to Adult Oligodendroglioma:

# Title Authors PMID Year
1
Pre- and post-surgery MRSI predictive value in adult oligodendroglioma prognosis. 38
29902567 2018
2
Outcomes and Prognostic Factors in Pediatric Oligodendroglioma: A Population-Based Study. 38
29131101 2018
3
Molecular characterization reveals NF1 deletions and FGFR1-activating mutations in a pediatric spinal oligodendroglioma. 38
27862886 2017
4
Mutation-specific IDH1 antibody differentiates oligodendrogliomas and oligoastrocytomas from other brain tumors with oligodendroglioma-like morphology. 38
21069360 2011

Variations for Adult Oligodendroglioma

Expression for Adult Oligodendroglioma

Search GEO for disease gene expression data for Adult Oligodendroglioma.

Pathways for Adult Oligodendroglioma

GO Terms for Adult Oligodendroglioma

Biological processes related to Adult Oligodendroglioma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular matrix organization GO:0030198 9.63 PDGFRA NF1 GFAP
2 tricarboxylic acid cycle GO:0006099 9.48 IDH2 IDH1
3 negative regulation of fibroblast proliferation GO:0048147 9.43 TP53 NF1
4 female gonad development GO:0008585 9.4 PDGFRA IDH1
5 adrenal gland development GO:0030325 9.37 PDGFRA NF1
6 2-oxoglutarate metabolic process GO:0006103 9.32 IDH2 IDH1
7 positive regulation of phospholipase C activity GO:0010863 9.26 PDGFRA FGFR1
8 NADP metabolic process GO:0006739 9.16 IDH2 IDH1
9 isocitrate metabolic process GO:0006102 8.96 IDH2 IDH1
10 glyoxylate cycle GO:0006097 8.62 IDH2 IDH1

Molecular functions related to Adult Oligodendroglioma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein homodimerization activity GO:0042803 9.46 PDGFRA OLIG2 IDH1 FGFR1
2 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GO:0016616 9.26 IDH2 IDH1
3 isocitrate dehydrogenase activity GO:0004448 8.96 IDH2 IDH1
4 isocitrate dehydrogenase (NADP+) activity GO:0004450 8.62 IDH2 IDH1

Sources for Adult Oligodendroglioma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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