MCID: ADL084
MIFTS: 22

Adult-Onset Myasthenia Gravis

Categories: Eye diseases, Immune diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Adult-Onset Myasthenia Gravis

MalaCards integrated aliases for Adult-Onset Myasthenia Gravis:

Name: Adult-Onset Myasthenia Gravis 59
Adult-Onset Autoimmune Myasthenia Gravis 59
Adult-Onset Acquired Myasthenia 59

Characteristics:

Orphanet epidemiological data:

59
adult-onset myasthenia gravis
Inheritance: Multigenic/multifactorial,Not applicable; Prevalence: 1-5/10000 (Serbia),1-9/100000 (Serbia),1-5/10000 (United States),1-5/10000 (United Kingdom),1-5/10000 (Europe); Age of onset: Adult;

Classifications:



External Ids:

Orphanet 59 ORPHA391490
ICD10 via Orphanet 34 G70.0

Summaries for Adult-Onset Myasthenia Gravis

MalaCards based summary : Adult-Onset Myasthenia Gravis, also known as adult-onset autoimmune myasthenia gravis, is related to myasthenia gravis and myasthenia gravis congenital. An important gene associated with Adult-Onset Myasthenia Gravis is HLA-DQA1 (Major Histocompatibility Complex, Class II, DQ Alpha 1), and among its related pathways/superpathways are NF-kappaB Signaling and ICos-ICosL Pathway in T-Helper Cell. Affiliated tissues include eye, and related phenotypes are Increased number of mitotic cells and endocrine/exocrine gland

Related Diseases for Adult-Onset Myasthenia Gravis

Diseases in the Myasthenia Gravis family:

Myasthenia Gravis Congenital Juvenile Myasthenia Gravis
Adult-Onset Myasthenia Gravis

Diseases related to Adult-Onset Myasthenia Gravis via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 myasthenia gravis 10.2
2 myasthenia gravis congenital 10.2
3 sympathetic ophthalmia 9.8 CTLA4 HLA-DQA1
4 autoimmune disease of gastrointestinal tract 9.8 CTLA4 HLA-DQA1
5 autoimmune disease 9.8 CTLA4 HLA-DQA1
6 alopecia areata 9.8 CTLA4 HLA-DQA1
7 celiac disease 1 9.8 CTLA4 HLA-DQA1
8 graves' disease 9.7 CTLA4 HLA-DQA1
9 diabetes mellitus, insulin-dependent 9.6 CTLA4 HLA-DQA1
10 rheumatoid arthritis 9.6 CTLA4 HLA-DQA1 TNFRSF11A

Graphical network of the top 20 diseases related to Adult-Onset Myasthenia Gravis:



Diseases related to Adult-Onset Myasthenia Gravis

Symptoms & Phenotypes for Adult-Onset Myasthenia Gravis

GenomeRNAi Phenotypes related to Adult-Onset Myasthenia Gravis according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased number of mitotic cells GR00098-A-3 8.62 HLA-DQA1 TNFRSF11A

MGI Mouse Phenotypes related to Adult-Onset Myasthenia Gravis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 8.8 CTLA4 HLA-DQA1 TNFRSF11A

Drugs & Therapeutics for Adult-Onset Myasthenia Gravis

Search Clinical Trials , NIH Clinical Center for Adult-Onset Myasthenia Gravis

Genetic Tests for Adult-Onset Myasthenia Gravis

Anatomical Context for Adult-Onset Myasthenia Gravis

MalaCards organs/tissues related to Adult-Onset Myasthenia Gravis:

41
Eye

Publications for Adult-Onset Myasthenia Gravis

Articles related to Adult-Onset Myasthenia Gravis:

# Title Authors Year
1
Survival and mortality of adult-onset myasthenia gravis in the population of Belgrade, Serbia. ( 29572981 )
2018
2
Epidemiological study of adult-onset myasthenia gravis in the area of Belgrade (Serbia) in the period 1979-2008. ( 23363926 )
2013

Variations for Adult-Onset Myasthenia Gravis

Expression for Adult-Onset Myasthenia Gravis

Search GEO for disease gene expression data for Adult-Onset Myasthenia Gravis.

Pathways for Adult-Onset Myasthenia Gravis

GO Terms for Adult-Onset Myasthenia Gravis

Cellular components related to Adult-Onset Myasthenia Gravis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 external side of plasma membrane GO:0009897 8.62 CTLA4 TNFRSF11A

Biological processes related to Adult-Onset Myasthenia Gravis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 adaptive immune response GO:0002250 8.62 CTLA4 TNFRSF11A

Sources for Adult-Onset Myasthenia Gravis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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