MCID: ADL084
MIFTS: 21

Adult-Onset Myasthenia Gravis

Categories: Eye diseases, Immune diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Adult-Onset Myasthenia Gravis

MalaCards integrated aliases for Adult-Onset Myasthenia Gravis:

Name: Adult-Onset Myasthenia Gravis 58
Adult-Onset Autoimmune Myasthenia Gravis 58
Adult-Onset Acquired Myasthenia 58

Characteristics:

Orphanet epidemiological data:

58
adult-onset myasthenia gravis
Inheritance: Multigenic/multifactorial,Not applicable; Prevalence: 1-5/10000 (Serbia),1-9/100000 (Serbia),1-5/10000 (United States),1-5/10000 (United Kingdom),1-5/10000 (Europe); Age of onset: Adult;

Classifications:

Orphanet: 58  
Rare neurological diseases
Rare eye diseases


External Ids:

ICD10 via Orphanet 33 G70.0
Orphanet 58 ORPHA391490

Summaries for Adult-Onset Myasthenia Gravis

MalaCards based summary : Adult-Onset Myasthenia Gravis, also known as adult-onset autoimmune myasthenia gravis, is related to myasthenia gravis and autoimmune disease. An important gene associated with Adult-Onset Myasthenia Gravis is CTLA4 (Cytotoxic T-Lymphocyte Associated Protein 4), and among its related pathways/superpathways are NF-kappaB Signaling and ICos-ICosL Pathway in T-Helper Cell. Affiliated tissues include eye, and related phenotype is Increased number of mitotic cells.

Related Diseases for Adult-Onset Myasthenia Gravis

Graphical network of the top 20 diseases related to Adult-Onset Myasthenia Gravis:



Diseases related to Adult-Onset Myasthenia Gravis

Symptoms & Phenotypes for Adult-Onset Myasthenia Gravis

GenomeRNAi Phenotypes related to Adult-Onset Myasthenia Gravis according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased number of mitotic cells GR00098-A-3 8.62 HLA-DQA1 TNFRSF11A

Drugs & Therapeutics for Adult-Onset Myasthenia Gravis

Search Clinical Trials , NIH Clinical Center for Adult-Onset Myasthenia Gravis

Genetic Tests for Adult-Onset Myasthenia Gravis

Anatomical Context for Adult-Onset Myasthenia Gravis

MalaCards organs/tissues related to Adult-Onset Myasthenia Gravis:

40
Eye

Publications for Adult-Onset Myasthenia Gravis

Articles related to Adult-Onset Myasthenia Gravis:

# Title Authors PMID Year
1
Comparison of anti-acetylcholine receptor profiles between Chinese cases of adult- and juvenile-onset myasthenia gravis using cell-based assays. 61
32992216 2020
2
Cell-Based Versus Enzyme-Linked Immunosorbent Assay for the Detection of Acetylcholine Receptor Antibodies in Chinese Juvenile Myasthenia Gravis. 61
31307830 2019
3
HLA typing using next-generation sequencing for Chinese juvenile- and adult-onset myasthenia gravis patients. 61
30595166 2019
4
Survival and mortality of adult-onset myasthenia gravis in the population of Belgrade, Serbia. 61
29572981 2018
5
Epidemiological study of adult-onset myasthenia gravis in the area of Belgrade (Serbia) in the period 1979-2008. 61
23363926 2013
6
A candidate gene for autoimmune myasthenia gravis. 61
22744667 2012
7
Myasthenia gravis. 61
9118787 1997
8
Acetylcholine receptor antibody in myasthenia gravis. 61
2589004 1989
9
Myasthenia gravis and HLA antigens in American blacks and other races. 61
6334696 1984

Variations for Adult-Onset Myasthenia Gravis

Expression for Adult-Onset Myasthenia Gravis

Search GEO for disease gene expression data for Adult-Onset Myasthenia Gravis.

Pathways for Adult-Onset Myasthenia Gravis

Pathways related to Adult-Onset Myasthenia Gravis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.88 TNFRSF11A CTLA4
2
Show member pathways
11.7 HLA-DQA1 CTLA4
3
Show member pathways
11.49 HLA-DQA1 CTLA4
4 11.33 HLA-DQA1 CTLA4
5 10.81 HLA-DQA1 CTLA4
6 10.77 TNFRSF11A HLA-DQA1 CTLA4

GO Terms for Adult-Onset Myasthenia Gravis

Cellular components related to Adult-Onset Myasthenia Gravis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 external side of plasma membrane GO:0009897 8.62 TNFRSF11A CTLA4

Biological processes related to Adult-Onset Myasthenia Gravis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 T cell receptor signaling pathway GO:0050852 8.96 HLA-DQA1 CTLA4
2 adaptive immune response GO:0002250 8.8 TNFRSF11A HLA-DQA1 CTLA4

Sources for Adult-Onset Myasthenia Gravis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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