MCID: ADL084
MIFTS: 22

Adult-Onset Myasthenia Gravis

Categories: Eye diseases, Immune diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Adult-Onset Myasthenia Gravis

MalaCards integrated aliases for Adult-Onset Myasthenia Gravis:

Name: Adult-Onset Myasthenia Gravis 60
Adult-Onset Autoimmune Myasthenia Gravis 60
Adult-Onset Acquired Myasthenia 60

Characteristics:

Orphanet epidemiological data:

60
adult-onset myasthenia gravis
Inheritance: Multigenic/multifactorial,Not applicable; Prevalence: 1-5/10000 (Serbia),1-9/100000 (Serbia),1-5/10000 (United States),1-5/10000 (United Kingdom),1-5/10000 (Europe); Age of onset: Adult;

Classifications:



External Ids:

ICD10 via Orphanet 35 G70.0
Orphanet 60 ORPHA391490

Summaries for Adult-Onset Myasthenia Gravis

MalaCards based summary : Adult-Onset Myasthenia Gravis, also known as adult-onset autoimmune myasthenia gravis, is related to myasthenia gravis and myasthenia gravis congenital. An important gene associated with Adult-Onset Myasthenia Gravis is HLA-DQA1 (Major Histocompatibility Complex, Class II, DQ Alpha 1), and among its related pathways/superpathways are NF-kappaB Signaling and ICos-ICosL Pathway in T-Helper Cell. Affiliated tissues include eye, and related phenotypes are Increased number of mitotic cells and endocrine/exocrine gland

Related Diseases for Adult-Onset Myasthenia Gravis

Diseases in the Myasthenia Gravis family:

Myasthenia Gravis Congenital Juvenile Myasthenia Gravis
Adult-Onset Myasthenia Gravis

Diseases related to Adult-Onset Myasthenia Gravis via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 myasthenia gravis 10.3
2 myasthenia gravis congenital 10.3
3 sympathetic ophthalmia 9.7 CTLA4 HLA-DQA1
4 autoimmune disease of gastrointestinal tract 9.7 CTLA4 HLA-DQA1
5 celiac disease 1 9.6 CTLA4 HLA-DQA1
6 graves' disease 9.6 CTLA4 HLA-DQA1
7 diabetes mellitus, insulin-dependent 9.4 CTLA4 HLA-DQA1
8 rheumatoid arthritis 9.4 CTLA4 HLA-DQA1 TNFRSF11A

Graphical network of the top 20 diseases related to Adult-Onset Myasthenia Gravis:



Diseases related to Adult-Onset Myasthenia Gravis

Symptoms & Phenotypes for Adult-Onset Myasthenia Gravis

GenomeRNAi Phenotypes related to Adult-Onset Myasthenia Gravis according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased number of mitotic cells GR00098-A-3 8.62 HLA-DQA1 TNFRSF11A

MGI Mouse Phenotypes related to Adult-Onset Myasthenia Gravis:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 8.8 CTLA4 HLA-DQA1 TNFRSF11A

Drugs & Therapeutics for Adult-Onset Myasthenia Gravis

Search Clinical Trials , NIH Clinical Center for Adult-Onset Myasthenia Gravis

Genetic Tests for Adult-Onset Myasthenia Gravis

Anatomical Context for Adult-Onset Myasthenia Gravis

MalaCards organs/tissues related to Adult-Onset Myasthenia Gravis:

42
Eye

Publications for Adult-Onset Myasthenia Gravis

Articles related to Adult-Onset Myasthenia Gravis:

# Title Authors Year
1
HLA typing using next-generation sequencing for Chinese juvenile- and adult-onset myasthenia gravis patients. ( 30595166 )
2019
2
Survival and mortality of adult-onset myasthenia gravis in the population of Belgrade, Serbia. ( 29572981 )
2018
3
Epidemiological study of adult-onset myasthenia gravis in the area of Belgrade (Serbia) in the period 1979-2008. ( 23363926 )
2013
4
Adult onset acquired myasthenia gravis in three Great Dane littermates. ( 18684140 )
2008

Variations for Adult-Onset Myasthenia Gravis

Expression for Adult-Onset Myasthenia Gravis

Search GEO for disease gene expression data for Adult-Onset Myasthenia Gravis.

Pathways for Adult-Onset Myasthenia Gravis

GO Terms for Adult-Onset Myasthenia Gravis

Cellular components related to Adult-Onset Myasthenia Gravis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 external side of plasma membrane GO:0009897 8.62 CTLA4 TNFRSF11A

Biological processes related to Adult-Onset Myasthenia Gravis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 adaptive immune response GO:0002250 8.62 CTLA4 TNFRSF11A

Sources for Adult-Onset Myasthenia Gravis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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