AOSD
MCID: ADL030
MIFTS: 67

Adult-Onset Still's Disease (AOSD)

Categories: Bone diseases, Nephrological diseases, Rare diseases

Aliases & Classifications for Adult-Onset Still's Disease

MalaCards integrated aliases for Adult-Onset Still's Disease:

Name: Adult-Onset Still's Disease 12 76 53 15
Adult-Onset Still Disease 12 59 73
Still's Disease, Adult-Onset 44
Adult Onset Still's Disease 12
Still's Disease Adult Onset 53
Stills Disease Adult-Onset 55
Adult Onset Still Disease 37
Wissler-Fanconi Syndrome 59
Adult Still's Disease 53
Wissler's Syndrome 73
Aosd 59

Characteristics:

Orphanet epidemiological data:

59
adult-onset still disease
Inheritance: Not applicable; Prevalence: 1-9/1000000 (France),1-9/1000000 (Japan),1-9/1000000 (Norway),1-9/100000 (Norway),1-9/100000 (Europe),1-9/1000000 (Turkey),1-9/100000 (Turkey); Age of onset: Adult; Age of death: normal life expectancy;

Classifications:



Summaries for Adult-Onset Still's Disease

NIH Rare Diseases : 53 Adult-onset Still's disease (AOSD) is an inflammatory disease characterized by high fevers, rash, sore throat, and joint pain. Several joints are often affected at the same time, and the joints are often stiff for several hours in the morning. Fevers develop each day (usually in the afternoon or evening), and the rash comes and goes with the fever. Other signs and symptoms may include abdominal pain, pleurisy, swollen lymph nodes, and weight loss. In some cases, the lungs and heart become inflamed. As it progresses, the disease may lead to chronic arthritis and other complications. The cause of AOSD is unknown, and no risk factors for the disease have been identified. It is diagnosed based on symptoms and the results of several blood tests. Blood test results may show a high white blood cell count, high C-reactive protein and ESR (measures of inflammation), high ferritin level, high fibrinogen level, and high levels of AST and ALT on liver function tests. AOSD is only diagnosed when other conditions such as infections and cancer are ruled out. Treatment aims to control inflammation, and prevent joint damage and other complications. Depending on severity and whether long-term management is needed, medications used may include non-steroidal inflammatory drugs, glucocorticoids, nonbiologic or biologic disease-modifying antirheumatic drugs (DMARDs), or other biologic agents. The long-term outlook depends on severity, whether the disease is chronic (long-lasting), and what organs or parts of the body are involved.  Of note, Still's disease which occurs in children (those under the age of 16) is known as systemic onset juvenile rheumatoid arthritis (JRA).

MalaCards based summary : Adult-Onset Still's Disease, also known as adult-onset still disease, is related to endocarditis and acute respiratory distress syndrome, and has symptoms including exanthema An important gene associated with Adult-Onset Still's Disease is IL18 (Interleukin 18), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Antirheumatic Agents and Interleukin 1 Receptor Antagonist Protein have been mentioned in the context of this disorder. Affiliated tissues include testes, liver and lymph node, and related phenotypes are arthritis and splenomegaly

Disease Ontology : 12 An arthritis that is a rare from of inflammatory arthritis characterized by fevers, rash, and joint pain.

Wikipedia : 76 Adult-onset Still''s disease (AOSD) is a form of Still''s disease, a rare systemic autoinflammatory... more...

Related Diseases for Adult-Onset Still's Disease

Diseases related to Adult-Onset Still's Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 301)
# Related Disease Score Top Affiliating Genes
1 endocarditis 30.1 CRP IL6 TNF
2 acute respiratory distress syndrome 30.0 IL1B IL6 TNF
3 drug reaction with eosinophilia and systemic symptoms 29.9 CRP TNF
4 leishmaniasis 29.8 IL1B IL6 TNF
5 colitis 29.8 IL1B IL6 TNF
6 chikungunya 29.8 IL1B IL6 TNF
7 cryopyrin-associated periodic syndrome 29.7 CRP IL1R1 IL1RN IL6
8 rheumatoid arthritis, systemic juvenile 29.7 IL1R1 IL6 MIF
9 meningitis 29.7 CRP IL1B IL6 TNF
10 pneumonia 29.7 CRP IL1B IL6 TNF
11 systemic onset juvenile idiopathic arthritis 29.4 IL1RN MEFV MIF TNF
12 sarcoidosis 1 29.4 IL18 IL1B MIF TNF
13 arthritis 29.2 CSF1 IL18 IL1B IL1RN IL6 MIF
14 pericarditis 28.9 CRP IL1B IL1RN IL6 MEFV TNF
15 rheumatoid arthritis 28.0 CRP CSF1 IL18 IL1B IL1R1 IL1RN
16 wissler's syndrome 12.0
17 fanconi syndrome 10.4
18 intussusception 10.3 CRP IL6
19 neutrophilia, hereditary 10.3 CRP IL6
20 spinal disease 10.3 CRP IL6
21 multicentric castleman disease 10.3 CRP IL6
22 viral pneumonia 10.3 CRP IL6
23 cecal disease 10.3 CRP IL6
24 relapsing polychondritis 10.3 CRP IL6
25 pyelitis 10.3 CRP IL6
26 subacute thyroiditis 10.3 CRP IL6
27 amyloidosis aa 10.3 CRP MEFV
28 listeria meningitis 10.3 IL18 TNF
29 melancholia 10.2 CRP TNF
30 salpingitis 10.2 CRP TNF
31 tuberculous peritonitis 10.2 CRP TNF
32 retinitis pigmentosa 55 10.2 IL6 TNF
33 angioimmunoblastic lymphadenopathy with dysproteinemia 10.2 IL6 TNF
34 critical limb ischemia 10.2 IL6 TNF
35 autoimmune gastritis 10.2 IL6 TNF
36 meconium aspiration syndrome 10.2 IL6 TNF
37 listeriosis 10.2 IL6 TNF
38 burning mouth syndrome 10.2 IL6 TNF
39 null-cell leukemia 10.2 IL6 TNF
40 anca-associated vasculitis 10.2 IL6 TNF
41 anterior uveitis 10.2 IL6 TNF
42 leukomalacia 10.2 IL6 TNF
43 posterior urethral valves 10.2 IL6 TNF
44 cardiogenic shock 10.2 IL6 TNF
45 streptococcal toxic-shock syndrome 10.2 IL6 TNF
46 cartilage disease 10.2 CRP IL1RN
47 autoinflammation, panniculitis, and dermatosis syndrome 10.2 MEFV TNF
48 erysipelas 10.2 MEFV TNF
49 alcoholic gastritis 10.2 IL18 IL1B
50 suppurative otitis media 10.2 CRP IL1B

Graphical network of the top 20 diseases related to Adult-Onset Still's Disease:



Diseases related to Adult-Onset Still's Disease

Symptoms & Phenotypes for Adult-Onset Still's Disease

Human phenotypes related to Adult-Onset Still's Disease:

59 32 (show all 30)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 arthritis 59 32 hallmark (90%) Very frequent (99-80%) HP:0001369
2 splenomegaly 59 32 hallmark (90%) Very frequent (99-80%) HP:0001744
3 hepatomegaly 59 32 hallmark (90%) Very frequent (99-80%) HP:0002240
4 fever 59 32 hallmark (90%) Very frequent (99-80%) HP:0001945
5 fatigue 59 32 hallmark (90%) Very frequent (99-80%) HP:0012378
6 joint swelling 59 32 hallmark (90%) Very frequent (99-80%) HP:0001386
7 arthralgia 59 32 hallmark (90%) Very frequent (99-80%) HP:0002829
8 hepatitis 59 32 occasional (7.5%) Occasional (29-5%) HP:0012115
9 bone marrow hypocellularity 59 32 occasional (7.5%) Occasional (29-5%) HP:0005528
10 abdominal pain 59 32 frequent (33%) Frequent (79-30%) HP:0002027
11 pruritus 59 32 hallmark (90%) Very frequent (99-80%) HP:0000989
12 myalgia 59 32 frequent (33%) Frequent (79-30%) HP:0003326
13 abnormality of lipid metabolism 59 32 occasional (7.5%) Occasional (29-5%) HP:0003119
14 leukocytosis 59 32 hallmark (90%) Very frequent (99-80%) HP:0001974
15 erythema 59 32 hallmark (90%) Very frequent (99-80%) HP:0010783
16 pericarditis 59 32 frequent (33%) Frequent (79-30%) HP:0001701
17 myocarditis 59 32 occasional (7.5%) Occasional (29-5%) HP:0012819
18 recurrent pharyngitis 59 32 occasional (7.5%) Occasional (29-5%) HP:0100776
19 skin rash 59 32 hallmark (90%) Very frequent (99-80%) HP:0000988
20 meningitis 59 32 occasional (7.5%) Occasional (29-5%) HP:0001287
21 elevated c-reactive protein level 59 32 hallmark (90%) Very frequent (99-80%) HP:0011227
22 cartilage destruction 59 32 occasional (7.5%) Occasional (29-5%) HP:0100773
23 pleuritis 59 32 frequent (33%) Frequent (79-30%) HP:0002102
24 restrictive ventilatory defect 59 32 hallmark (90%) Very frequent (99-80%) HP:0002091
25 elevated erythrocyte sedimentation rate 59 32 hallmark (90%) Very frequent (99-80%) HP:0003565
26 generalized lymphadenopathy 59 32 frequent (33%) Frequent (79-30%) HP:0008940
27 elevated hepatic transaminases 59 Occasional (29-5%)
28 neutrophillia 59 Very frequent (99-80%)
29 neutrophilia 32 hallmark (90%) HP:0011897
30 elevated hepatic transaminase 32 occasional (7.5%) HP:0002910

UMLS symptoms related to Adult-Onset Still's Disease:


exanthema

MGI Mouse Phenotypes related to Adult-Onset Still's Disease:

46 (show all 15)
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.22 CRP CSF1 IL18 IL1B IL1R1 IL1RN
2 immune system MP:0005387 10.2 CRP CSF1 IL18 IL1B IL1R1 IL1RN
3 cardiovascular system MP:0005385 10.19 CRP CSF1 IL18 IL1B IL1R1 IL1RN
4 hematopoietic system MP:0005397 10.19 CSF1 IL18 IL1B IL1R1 IL1RN IL6
5 cellular MP:0005384 10.18 CSF1 IL18 IL1R1 IL1RN IL6 MEFV
6 growth/size/body region MP:0005378 10.16 CSF1 IL18 IL1B IL1R1 IL1RN IL6
7 integument MP:0010771 10.09 CSF1 IL18 IL1B IL1R1 IL1RN IL6
8 mortality/aging MP:0010768 10.02 CSF1 IL18 IL1B IL1R1 IL1RN IL6
9 adipose tissue MP:0005375 9.95 IL18 IL1R1 IL6 TNF TNFRSF1A
10 liver/biliary system MP:0005370 9.88 CSF1 IL1R1 IL6 MEFV TNF TNFRSF1A
11 muscle MP:0005369 9.8 CSF1 IL18 IL1R1 IL6 TNF TNFRSF1A
12 nervous system MP:0003631 9.76 CSF1 IL18 IL1B IL1R1 IL6 MIF
13 neoplasm MP:0002006 9.73 IL1B IL1R1 IL6 MIF TNF TNFRSF1A
14 skeleton MP:0005390 9.56 CSF1 IL1B IL1R1 IL1RN IL6 MEFV
15 vision/eye MP:0005391 9.1 CSF1 IL18 IL1R1 IL6 TNF TNFRSF1A

Drugs & Therapeutics for Adult-Onset Still's Disease

Drugs for Adult-Onset Still's Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 27)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Antirheumatic Agents Phase 3,Phase 2
2 Interleukin 1 Receptor Antagonist Protein Phase 3,Phase 2
3
Methylprednisolone hemisuccinate Approved Phase 2 2921-57-5
4
leucovorin Approved Phase 2 58-05-9 6006 143
5
Azathioprine Approved Phase 2 446-86-6 2265
6
Prednisolone Approved, Vet_approved Phase 2 50-24-8 5755
7
Methylprednisolone Approved, Vet_approved Phase 2 83-43-2 6741
8
Prednisolone phosphate Approved, Vet_approved Phase 2 302-25-0
9
Methotrexate Approved Phase 2 59-05-2, 1959-05-2 126941
10
Leflunomide Approved, Investigational Phase 2 75706-12-6 3899
11
Folic Acid Approved, Nutraceutical, Vet_approved Phase 2 59-30-3 6037
12
Prednisolone hemisuccinate Experimental Phase 2 2920-86-7
13 Antibodies, Monoclonal Phase 2
14 Immunoglobulins Phase 2
15 Antibodies Phase 2
16 Folic Acid Antagonists Phase 2
17 Prednisolone acetate Phase 2
18 Immunologic Factors Phase 2
19 Vitamin B Complex Phase 2
20 Immunosuppressive Agents Phase 2
21 Methylprednisolone acetate Phase 2
22 Folate Phase 2
23 Dermatologic Agents Phase 2
24 Antimetabolites Phase 2
25 Antimetabolites, Antineoplastic Phase 2
26 Nucleic Acid Synthesis Inhibitors Phase 2
27 Vitamin B9 Phase 2

Interventional clinical trials:

(show all 11)
# Name Status NCT ID Phase Drugs
1 A Study to Evaluate Efficacy and Safety of Anakinra in the Treatment of Still's Disease (SJIA and AOSD) Recruiting NCT03265132 Phase 3 Placebo
2 Efficacy and Safety of Tocilizumab in Adult's Still Disease Unknown status NCT01002781 Phase 2 Tocilizumab
3 Treatment of Refractory Adult-onset Still's Disease With Anakinra: a Randomized Study Completed NCT01033656 Phase 2 anakinra;comparators
4 Therapeutic Use of Tadekinig Alfa in Adult-onset Still's Disease Completed NCT02398435 Phase 2
5 Interleukin-1 Trap to Treat Autoinflammatory Diseases Completed NCT00094900 Phase 2 IL-1 Trap
6 Tocilizumab in Patients With Schnitzler's Syndrome Recruiting NCT03046381 Phase 2 Tocilizumab
7 Canakinumab for Treatment of Adult Onset Still's Disease Terminated NCT02204293 Phase 2 Canakinumab;Placebo Injection;Canakinumab
8 Admission of Adult-onset Still Disease Patients in the ICU Completed NCT03276650
9 Natural History, Genetics, and Pathophysiology of Systemic Juvenile Idiopathic Arthritis, Adult-Onset Still's Disease, and Related Conditions Recruiting NCT03510442
10 Glycosylated Ferritin in Macrophagic Activation Syndromes Recruiting NCT02143986
11 Multi-center Registration Study of Adult Onset Still's Disease in Chinese Population Not yet recruiting NCT03651193

Search NIH Clinical Center for Adult-Onset Still's Disease

Cochrane evidence based reviews: still's disease, adult-onset

Genetic Tests for Adult-Onset Still's Disease

Anatomical Context for Adult-Onset Still's Disease

MalaCards organs/tissues related to Adult-Onset Still's Disease:

41
Testes, Liver, Lymph Node, Lung, Heart, Bone, Skin

Publications for Adult-Onset Still's Disease

Articles related to Adult-Onset Still's Disease:

(show top 50) (show all 797)
# Title Authors Year
1
Beneficial use of serum ferritin and heme oxygenase-1 as biomarkers in adult-onset Still's disease: A multicenter retrospective study. ( 29278009 )
2018
2
Impaired autophagic flux and its related inflammation in patients with adult-onset Still's disease. ( 29416600 )
2018
3
Evidence for genetic overlap between adult onset Still's disease and hereditary periodic fever syndromes. ( 29159471 )
2018
4
Biological agents in the management of adult-onset Still's disease. ( 29631071 )
2018
5
A case of adult onset Still's disease with mutations of the MEFV gene who is partially responsive to colchicine. ( 29642170 )
2018
6
Interleukin-37 is increased in adult-onset Still's disease and associated with disease activity. ( 29566725 )
2018
7
Generalized Purpura as an Atypical Skin Manifestation of Adult-onset Still's Disease in a Patient with BehAset's Disease. ( 29313056 )
2018
8
Severe Pulmonary Hypertension Due to Adult-Onset Still's Disease. ( 29468168 )
2018
9
Adult-onset Still's disease initially thought to be an odontogenic infection: A case report. ( 29733534 )
2018
10
Molecular genetic analysis for periodic fever syndromes: a supplemental role for the diagnosis of adult-onset Still's disease. ( 29909561 )
2018
11
Acute appendicitis complicated with necrotizing fasciitis in a patient with adult-onset Still's disease: A case report. ( 29384877 )
2018
12
Adult Onset Still's Disease: A Classic Presentation of a Rare Illness. ( 29906427 )
2018
13
Biological therapy of traditional therapy-resistant adult-onset Still's disease: an evidence-based review. ( 29416343 )
2018
14
Two Severe Cases of Adult-onset Still's Disease with Persistent Pruritic Eruptions. ( 29362813 )
2018
15
Early use of anakinra in adult-onset Still's disease myocarditis. ( 29291663 )
2018
16
Adult-onset Still's disease with prominent polyserositis. ( 29506437 )
2018
17
Efficacy and safety of tocilizumab with inhibition of interleukin-6 in adult-onset Still's disease: A meta-analysis. ( 29251027 )
2018
18
Adding colchicine to immunosuppressive treatments; a potential option for biologics-refractory adult-onset Still's disease. ( 29784018 )
2018
19
Complications of adult-onset Still's disease and their management. ( 29658384 )
2018
20
Efficacy of Denosumab for Osteoporosis in Two Patients with Adult-Onset Still's Disease-Denosumab Efficacy in Osteoporotic Still's Disease Patients. ( 29565301 )
2018
21
Atypical form of Adult-onset Still's Disease with Distal Interphalangeal Joints Involvement. ( 28758587 )
2018
22
Adult onset Still's disease occurring during pregnancy: Case-report and literature review. ( 28781105 )
2018
23
Open-label, multicentre, dose-escalating phase II clinical trial on the safety and efficacy of tadekinig alfa (IL-18BP) in adult-onset Still's disease. ( 29472362 )
2018
24
Therapeutic innovation in adult-onset Still's disease (and other rare inflammatory disorders): how to secure evidence-based medicine? ( 29860231 )
2018
25
Macrophage Activation Syndrome Associated With Adult Onset Still's Disease. ( 29938438 )
2018
26
Adult-Onset Still's Disease and Macrophage-Activating Syndrome Progressing to Lymphoma: A Clinical Pathology Conference Held by the Division of Rheumatology at Hospital for Special Surgery. ( 29983666 )
2018
27
Interleukin-18 as a diagnostic marker of adult-onset Still's disease in older patients: a case report and review of the literature. ( 29986752 )
2018
28
An atypical persistent eruption of adult-onset Still's disease with neutrophilic urticarial dermatosis-like dermal features: A case report and review of the literature. ( 29992610 )
2018
29
A Case of Adult-Onset Still's Disease Caused by a Novel Splicing Mutation in TNFAIP3 Successfully Treated With Tocilizumab. ( 30022980 )
2018
30
Are the 2016 EULAR/ACR/PRINTO classification criteria for macrophage activation syndrome applicable to patients with adult-onset Still's disease? ( 30051293 )
2018
31
Characteristic patterns of HLA presentation and T cell differentiation in adult-onset Still's disease. ( 30052100 )
2018
32
Adult-Onset Still's Disease: Molecular Pathophysiology and Therapeutic Advances. ( 30069732 )
2018
33
A comprehensive review on adult onset Still's disease. ( 30077425 )
2018
34
Adult-onset Still's disease with haemorrhagic pericarditis and tamponade preceded by acute Lyme disease. ( 30115716 )
2018
35
HLA-DQB1 DPB1 alleles in Japanese patients with adult-onset Still's disease. ( 30136608 )
2018
36
Case of adult-onset Still's disease with psoriasiform eruptions. ( 30144140 )
2018
37
Tracheal, laryngeal and pulmonary mucormycosis followed by organizing pneumonia in a patient with Adult Onset Still's Disease. ( 30148059 )
2018
38
Severe Adult-Onset Still's Disease Mimicking Systemic Infection. ( 30186016 )
2018
39
Mechanisms, biomarkers and targets for adult-onset Still's disease. ( 30218025 )
2018
40
Successful treatment with anakinra of an HIV-associated immune reconstitution inflammatory syndrome mimicking adult-onset Still's disease. ( 30239973 )
2018
41
Adult-onset Still's Disease in a Female Patient with Schizophrenia: A Case Report and Literature Review. ( 30254808 )
2018
42
Tocilizumab in patients with adult-onset still's disease refractory to glucocorticoid treatment: a randomised, double-blind, placebo-controlled phase III trial. ( 30279267 )
2018
43
Pathogenesis of adult onset still's disease: current understanding and new insights. ( 30295095 )
2018
44
Development and Role in Therapy of Canakinumab in Adult-Onset Still's Disease. ( 30298010 )
2018
45
Noncaseating suppurative granulomatous lymphadenitis in adult onset Still's disease - a diagnostic dilemma in a tuberculosis-endemic region: a case report. ( 30318016 )
2018
46
Anakinra for the treatment of adult-onset Still's disease. ( 30324816 )
2018
47
Adult Onset Still's Disease Masquerading as Sepsis in an Asplenic Patient. ( 30341856 )
2018
48
Prolonged treatment with Tadekinig alfa in adult-onset Still's disease. ( 30352887 )
2018
49
Tocilizumab in patients with adult-onset Still's disease refractory to glucocorticoid treatment. ( 30389689 )
2018
50
Histopathological diagnosis of persistent pruritic eruptions associated with adult-onset Still's disease. ( 30408204 )
2018

Variations for Adult-Onset Still's Disease

Expression for Adult-Onset Still's Disease

Search GEO for disease gene expression data for Adult-Onset Still's Disease.

Pathways for Adult-Onset Still's Disease

Pathways related to Adult-Onset Still's Disease according to GeneCards Suite gene sharing:

(show top 50) (show all 80)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.83 CRP CSF1 IL18 IL1B IL1R1 IL1RN
2
Show member pathways
13.77 CSF1 IL18 IL1B IL1R1 IL6 TNF
3
Show member pathways
13.59 CSF1 IL18 IL1B IL1R1 IL1RN IL6
4
Show member pathways
13.46 IL18 IL1B IL1R1 IL6 TNF TNFRSF1A
5
Show member pathways
13.37 CSF1 IL18 IL1B IL1R1 IL6 TNF
6
Show member pathways
13.28 CSF1 IL18 IL1B IL1R1 IL1RN IL6
7
Show member pathways
13.26 CSF1 IL18 IL1B IL1R1 IL6 TNF
8
Show member pathways
13.01 IL1B IL1R1 IL6 TNF TNFRSF1A
9
Show member pathways
12.99 IL18 IL1B IL6 MEFV TNF TNFRSF1A
10
Show member pathways
12.86 IL18 IL1B IL6 TNF TNFRSF1A
11
Show member pathways
12.79 IL18 IL1B IL6 TNF TNFRSF1A
12 12.76 CSF1 IL1B IL1R1 TNF TNFRSF1A
13
Show member pathways
12.71 IL18 IL1B IL6 TNF
14
Show member pathways
12.7 IL1B IL1R1 IL6 TNF TNFRSF1A
15
Show member pathways
12.64 IL1B IL1R1 TNF TNFRSF1A
16
Show member pathways
12.6 IL18 IL1B IL1R1 IL6 TNF
17
Show member pathways
12.58 IL1B IL1R1 TNF TNFRSF1A
18
Show member pathways
12.56 IL18 IL1B IL6 TNF
19 12.54 IL1B IL1RN TNF TNFRSF1A
20 12.42 IL1R1 IL6 TNF TNFRSF1A
21
Show member pathways
12.34 CRP CSF1 IL1B IL6 TNF
22
Show member pathways
12.32 IL1B IL1R1 IL6 MIF TNF
23
Show member pathways
12.24 IL18 IL1B IL6 TNF
24 12.23 IL18 IL1B IL6 TNF TNFRSF1A
25
Show member pathways
12.21 IL1B IL1R1 IL6 TNF
26
Show member pathways
12.2 IL1B TNF TNFRSF1A
27 12.2 IL1B IL1RN IL6 TNF
28
Show member pathways
12.17 IL1B IL6 TNF
29
Show member pathways
12.17 IL1B TNF TNFRSF1A
30 12.14 IL6 TNF TNFRSF1A
31 12.12 IL1B IL1R1 TNF TNFRSF1A
32
Show member pathways
12.08 IL18 IL1B IL1R1 IL6 TNFRSF1A
33
Show member pathways
12.05 IL18 IL1B IL1R1 IL6 TNF
34 12.04 IL6 MIF TNF
35 12.03 CSF1 IL1B IL1R1 TNF TNFRSF1A
36
Show member pathways
12.02 IL1B IL6 TNF
37 12.01 IL18 IL1B IL6 TNF
38 11.98 CSF1 IL6 TNF
39
Show member pathways
11.96 IL18 IL1B IL1R1
40
Show member pathways
11.95 IL6 TNF TNFRSF1A
41 11.95 IL1B IL1R1 IL6 MIF TNF
42 11.92 IL1B IL1R1 IL6 TNF
43 11.91 IL1B IL1R1 TNF TNFRSF1A
44 11.9 IL1B IL6 TNF
45
Show member pathways
11.88 IL18 IL1B IL1R1 IL1RN IL6 TNF
46 11.87 CSF1 IL1B IL6 TNF TNFRSF1A
47 11.83 IL18 IL1B IL6
48 11.82 IL18 IL1B IL1R1 TNF
49 11.78 IL1B IL6 TNF
50 11.78 CSF1 IL1B IL6 TNF

GO Terms for Adult-Onset Still's Disease

Cellular components related to Adult-Onset Still's Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.61 CRP CSF1 IL18 IL1B IL1RN IL6
2 vesicle GO:0031982 9.33 IL1B IL1RN MIF
3 extracellular region GO:0005576 9.32 CRP CSF1 IL18 IL1B IL1R1 IL1RN

Biological processes related to Adult-Onset Still's Disease according to GeneCards Suite gene sharing:

(show top 50) (show all 55)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 9.95 CRP CSF1 IL18 IL1B IL6 TNF
2 positive regulation of protein phosphorylation GO:0001934 9.89 IL1B MIF TNF
3 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 9.89 IL1B IL1RN TNF TNFRSF1A
4 cellular response to lipopolysaccharide GO:0071222 9.88 IL1B IL1RN IL6 TNF
5 positive regulation of DNA-binding transcription factor activity GO:0051091 9.86 IL1B IL6 TNF
6 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.86 IL18 IL1B IL6 TNF
7 defense response to Gram-positive bacterium GO:0050830 9.85 CRP IL6 TNF
8 positive regulation of JNK cascade GO:0046330 9.85 IL1B IL1RN TNF
9 positive regulation of peptidyl-serine phosphorylation GO:0033138 9.85 IL6 MIF TNF
10 positive regulation of inflammatory response GO:0050729 9.83 IL18 TNF TNFRSF1A
11 cellular response to organic cyclic compound GO:0071407 9.82 IL18 IL1B TNF
12 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.82 IL18 IL6 TNFRSF1A
13 response to glucocorticoid GO:0051384 9.81 IL1B IL1RN IL6 TNF
14 positive regulation of smooth muscle cell proliferation GO:0048661 9.8 IL18 IL6 TNF
15 positive regulation of interleukin-6 production GO:0032755 9.8 IL1B IL1RN IL6 TNF
16 regulation of signaling receptor activity GO:0010469 9.8 CSF1 IL18 IL1B IL1RN IL6 MIF
17 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.79 IL18 IL1B TNF
18 interleukin-1-mediated signaling pathway GO:0070498 9.78 IL1B IL1R1 IL1RN
19 positive regulation of JUN kinase activity GO:0043507 9.76 IL1B IL1RN TNF
20 lipopolysaccharide-mediated signaling pathway GO:0031663 9.74 IL18 IL1B TNF
21 positive regulation of cytokine secretion GO:0050715 9.72 MIF TNF
22 positive regulation of interleukin-8 production GO:0032757 9.72 IL1B TNF
23 negative regulation of neurogenesis GO:0050768 9.72 IL1B IL6 TNF
24 negative regulation of myoblast differentiation GO:0045662 9.71 IL18 TNF
25 positive regulation of osteoclast differentiation GO:0045672 9.71 CSF1 TNF
26 positive regulation of glial cell proliferation GO:0060252 9.71 IL1B IL6 TNF
27 positive regulation of interferon-gamma production GO:0032729 9.71 IL18 IL1B IL1R1 TNF
28 positive regulation of chemokine production GO:0032722 9.7 IL6 TNF
29 carboxylic acid metabolic process GO:0019752 9.7 IL1RN MIF
30 negative regulation of lipid catabolic process GO:0050995 9.7 IL1B TNF
31 positive regulation of macrophage derived foam cell differentiation GO:0010744 9.7 CSF1 IL18
32 regulation of I-kappaB kinase/NF-kappaB signaling GO:0043122 9.69 IL1B TNF
33 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.69 IL1B TNF
34 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.69 IL1B TNF
35 positive regulation of granulocyte macrophage colony-stimulating factor production GO:0032725 9.68 IL18 IL1B
36 positive regulation of ceramide biosynthetic process GO:2000304 9.68 TNF TNFRSF1A
37 death-inducing signaling complex assembly GO:0071550 9.67 TNF TNFRSF1A
38 positive regulation of chemokine biosynthetic process GO:0045080 9.66 IL1B TNF
39 interleukin-6 production GO:0032635 9.65 IL18 IL1B
40 negative regulation of glutamate secretion GO:0014050 9.65 IL1B IL1RN
41 negative regulation of interleukin-1-mediated signaling pathway GO:2000660 9.64 IL1RN IL6
42 positive regulation of chemokine (C-X-C motif) ligand 2 production GO:2000343 9.63 MIF TNF
43 positive regulation of fever generation GO:0031622 9.63 IL1B TNF
44 negative regulation of lipid storage GO:0010888 9.63 CRP IL6 TNF
45 sequestering of triglyceride GO:0030730 9.61 IL1B TNF
46 regulation of establishment of endothelial barrier GO:1903140 9.61 IL1B TNF TNFRSF1A
47 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.6 IL1B TNF
48 cytokine-mediated signaling pathway GO:0019221 9.56 CSF1 IL18 IL1B IL1R1 IL1RN IL6
49 positive regulation of T-helper 1 cell cytokine production GO:2000556 9.54 IL18 IL1B IL1R1
50 chronic inflammatory response to antigenic stimulus GO:0002439 9.5 IL1B IL1RN TNF

Molecular functions related to Adult-Onset Still's Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.72 CRP CSF1 MEFV MIF TNF
2 cytokine activity GO:0005125 9.17 CSF1 IL18 IL1B IL1RN IL6 MIF
3 interleukin-1 receptor binding GO:0005149 9.16 IL1B IL1RN
4 protease binding GO:0002020 9.13 IL1R1 MIF TNF
5 protein binding GO:0005515 10 CRP CSF1 IL18 IL1B IL1R1 IL1RN

Sources for Adult-Onset Still's Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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