MCID: ADL030
MIFTS: 64

Adult-Onset Still's Disease

Categories: Rare diseases, Nephrological diseases, Bone diseases

Aliases & Classifications for Adult-Onset Still's Disease

MalaCards integrated aliases for Adult-Onset Still's Disease:

Name: Adult-Onset Still's Disease 12 76 53 15
Adult-Onset Still Disease 12 59 73
Adult Onset Still's Disease 12 37
Still's Disease, Adult-Onset 44
Still's Disease Adult Onset 53
Stills Disease Adult-Onset 55
Wissler-Fanconi Syndrome 59
Adult Still's Disease 53
Wissler's Syndrome 73
Aosd 59

Characteristics:

Orphanet epidemiological data:

59
adult-onset still disease
Inheritance: Not applicable; Prevalence: 1-9/1000000 (France),1-9/1000000 (Japan),1-9/1000000 (Norway),1-9/100000 (Norway),1-9/100000 (Europe),1-9/1000000 (Turkey),1-9/100000 (Turkey); Age of onset: Adult; Age of death: normal life expectancy;

Classifications:



Summaries for Adult-Onset Still's Disease

NIH Rare Diseases : 53 Adult-onset Still's disease (AOSD) is an inflammatory disease characterized by high fevers, rash, sore throat, and joint pain. Several joints are often affected at the same time, and the joints are often stiff for several hours in the morning. Fevers develop each day (usually in the afternoon or evening), and the rash comes and goes with the fever. Other signs and symptoms may include abdominal pain, pleurisy, swollen lymph nodes, and weight loss. In some cases, the lungs and heart become inflamed. As it progresses, the disease may lead to chronic arthritis and other complications. The cause of AOSD is unknown, and no risk factors for the disease have been identified. It is diagnosed based on symptoms and the results of several blood tests. Blood test results may show a high white blood cell count, high C-reactive protein and ESR (measures of inflammation), high ferritin level, high fibrinogen level, and high levels of AST and ALT on liver function tests. AOSD is only diagnosed when other conditions such as infections and cancer are ruled out. Treatment aims to control inflammation, and prevent joint damage and other complications. Depending on severity and whether long-term management is needed, medications used may include non-steroidal inflammatory drugs, glucocorticoids, nonbiologic or biologic disease-modifying antirheumatic drugs (DMARDs), or other biologic agents. The long-term outlook depends on severity, whether the disease is chronic (long-lasting), and what organs or parts of the body are involved.  Of note, Still's disease which occurs in children (those under the age of 16) is known as systemic onset juvenile rheumatoid arthritis (JRA).

MalaCards based summary : Adult-Onset Still's Disease, also known as adult-onset still disease, is related to cellulitis and chikungunya, and has symptoms including exanthema An important gene associated with Adult-Onset Still's Disease is IL18 (Interleukin 18), and among its related pathways/superpathways are Innate Immune System and PEDF Induced Signaling. The drugs Antirheumatic Agents and Interleukin 1 Receptor Antagonist Protein have been mentioned in the context of this disorder. Affiliated tissues include testes, liver and lymph node, and related phenotypes are skin rash and pruritus

Disease Ontology : 12 An arthritis that is a rare from of inflammatory arthritis characterized by fevers, rash, and joint pain.

Wikipedia : 76 Adult-onset Still\'s disease (AOSD) is a form of Still\'s disease, a rare systemic autoinflammatory... more...

Related Diseases for Adult-Onset Still's Disease

Diseases related to Adult-Onset Still's Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 273)
# Related Disease Score Top Affiliating Genes
1 cellulitis 30.2 CRP IL1R1 TNF
2 chikungunya 29.8 IL1B IL6 TNF
3 rheumatoid arthritis, systemic juvenile 29.7 IL1R1 IL6 MIF
4 cryopyrin-associated periodic syndrome 29.6 CRP IL1R1 IL1RN IL6
5 visceral leishmaniasis 29.4 CRP IL18 IL1B TNF
6 systemic onset juvenile idiopathic arthritis 29.3 IL18 IL1B MEFV TNF
7 pericarditis 28.7 CRP IL1B IL6 MEFV TNF
8 arthritis 26.0 CSF1 IL18 IL1B IL1RN IL6 MIF
9 wissler's syndrome 11.9
10 cold agglutinin disease 10.8 CRP IL6
11 cardiogenic shock 10.8 CRP IL6
12 neutrophilia, hereditary 10.8 CRP IL6
13 spinal disease 10.8 CRP IL6
14 castleman disease 10.8 CRP IL6
15 scorpion envenomation 10.7 IL6 TNF
16 angina pectoris 10.7 CRP IL6
17 viral pneumonia 10.7 CRP IL6
18 leukomalacia 10.7 IL6 TNF
19 angioimmunoblastic lymphadenopathy with dysproteinemia 10.7 IL6 TNF
20 cecal disease 10.7 CRP IL6
21 relapsing polychondritis 10.7 CRP IL6
22 critical limb ischemia 10.7 IL6 TNF
23 streptococcal toxic-shock syndrome 10.7 IL6 TNF
24 subacute thyroiditis 10.7 CRP IL6
25 null-cell leukemia 10.7 IL6 TNF
26 hypersensitivity vasculitis 10.6 CRP MEFV
27 melancholia 10.6 CRP TNF
28 amyloidosis aa 10.6 CRP MEFV
29 intussusception 10.6 CRP IL6
30 retinitis pigmentosa 55 10.6 IL6 TNF
31 anca-associated vasculitis 10.6 IL6 TNF
32 listeria meningitis 10.6 IL18 TNF
33 hyper-igd syndrome 10.6 CRP IL1RN
34 autoinflammation, panniculitis, and dermatosis syndrome 10.6 MEFV TNF
35 multicentric castleman disease 10.6 CRP IL6
36 posterior urethral valves 10.6 IL6 TNF
37 cartilage disease 10.6 CRP IL1RN
38 recurrent corneal erosion 10.6 IL1B IL6
39 microscopic colitis 10.6 IL6 TNF
40 meconium aspiration syndrome 10.5 IL6 TNF
41 bagassosis 10.5 IL1B IL6
42 erysipelas 10.5 MEFV TNF
43 acute cystitis 10.5 CRP IL18 IL6
44 burning mouth syndrome 10.5 IL6 TNF
45 periodontitis, chronic 10.5 IL1B IL6
46 inflammatory bowel disease 3 10.5 IL18 TNF
47 pericoronitis 10.5 CRP IL1B
48 funisitis 10.5 IL1B IL6
49 glossitis 10.5 IL1B IL6
50 periodic fever, familial, autosomal dominant 10.5 MEFV TNF

Graphical network of the top 20 diseases related to Adult-Onset Still's Disease:



Diseases related to Adult-Onset Still's Disease

Symptoms & Phenotypes for Adult-Onset Still's Disease

Human phenotypes related to Adult-Onset Still's Disease:

59 32 (show all 29)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 skin rash 59 32 hallmark (90%) Very frequent (99-80%) HP:0000988
2 pruritus 59 32 hallmark (90%) Very frequent (99-80%) HP:0000989
3 meningitis 59 32 occasional (7.5%) Occasional (29-5%) HP:0001287
4 arthritis 59 32 hallmark (90%) Very frequent (99-80%) HP:0001369
5 joint swelling 59 32 hallmark (90%) Very frequent (99-80%) HP:0001386
6 pericarditis 59 32 frequent (33%) Frequent (79-30%) HP:0001701
7 splenomegaly 59 32 hallmark (90%) Very frequent (99-80%) HP:0001744
8 fever 59 32 hallmark (90%) Very frequent (99-80%) HP:0001945
9 leukocytosis 59 32 hallmark (90%) Very frequent (99-80%) HP:0001974
10 abdominal pain 59 32 frequent (33%) Frequent (79-30%) HP:0002027
11 restrictive ventilatory defect 59 32 hallmark (90%) Very frequent (99-80%) HP:0002091
12 pleuritis 59 32 frequent (33%) Frequent (79-30%) HP:0002102
13 hepatomegaly 59 32 hallmark (90%) Very frequent (99-80%) HP:0002240
14 arthralgia 59 32 hallmark (90%) Very frequent (99-80%) HP:0002829
15 elevated hepatic transaminases 59 32 occasional (7.5%) Occasional (29-5%) HP:0002910
16 abnormality of lipid metabolism 59 32 occasional (7.5%) Occasional (29-5%) HP:0003119
17 myalgia 59 32 frequent (33%) Frequent (79-30%) HP:0003326
18 elevated erythrocyte sedimentation rate 59 32 hallmark (90%) Very frequent (99-80%) HP:0003565
19 bone marrow hypocellularity 59 32 occasional (7.5%) Occasional (29-5%) HP:0005528
20 generalized lymphadenopathy 59 32 frequent (33%) Frequent (79-30%) HP:0008940
21 erythema 59 32 hallmark (90%) Very frequent (99-80%) HP:0010783
22 elevated c-reactive protein level 59 32 hallmark (90%) Very frequent (99-80%) HP:0011227
23 hepatitis 59 32 occasional (7.5%) Occasional (29-5%) HP:0012115
24 fatigue 59 32 hallmark (90%) Very frequent (99-80%) HP:0012378
25 myocarditis 59 32 occasional (7.5%) Occasional (29-5%) HP:0012819
26 cartilage destruction 59 32 occasional (7.5%) Occasional (29-5%) HP:0100773
27 recurrent pharyngitis 59 32 occasional (7.5%) Occasional (29-5%) HP:0100776
28 neutrophillia 59 Very frequent (99-80%)
29 neutrophilia 32 hallmark (90%) HP:0011897

UMLS symptoms related to Adult-Onset Still's Disease:


exanthema

MGI Mouse Phenotypes related to Adult-Onset Still's Disease:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.1 IL6 IL1B CSF1 IL1R1 FCGR2A IL1RN
2 cardiovascular system MP:0005385 10.08 IL1B CRP CSF1 IL1R1 IL1RN IL18
3 homeostasis/metabolism MP:0005376 10.07 IL6 IL1B CRP CSF1 IL1R1 IL1RN
4 cellular MP:0005384 10.06 CSF1 IL1R1 IL1RN IL18 TNF IL6
5 immune system MP:0005387 10.06 IL6 IL1B CRP CSF1 IL1R1 FCGR2A
6 growth/size/body region MP:0005378 10.03 IL1RN IL18 IL1B CSF1 IL1R1 TNF
7 integument MP:0010771 9.86 IL6 IL1B CSF1 IL1R1 IL1RN IL18
8 mortality/aging MP:0010768 9.81 IL1B CSF1 IL1R1 FCGR2A IL1RN IL18
9 neoplasm MP:0002006 9.35 IL1B IL1R1 TNF IL6 MIF
10 skeleton MP:0005390 9.23 IL1B CSF1 IL1R1 FCGR2A IL1RN TNF

Drugs & Therapeutics for Adult-Onset Still's Disease

Drugs for Adult-Onset Still's Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 26)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Antirheumatic Agents Phase 3,Phase 2
2 Interleukin 1 Receptor Antagonist Protein Phase 3,Phase 2
3
Azathioprine Approved Phase 2 446-86-6 2265
4
Leflunomide Approved, Investigational Phase 2 75706-12-6 3899
5
Methotrexate Approved Phase 2 1959-05-2, 59-05-2 126941
6
Methylprednisolone Approved, Vet_approved Phase 2 83-43-2 6741
7
Prednisolone Approved, Vet_approved Phase 2 50-24-8 5755
8
Folic Acid Approved, Nutraceutical, Vet_approved Phase 2 59-30-3 6037
9
leucovorin Approved, Nutraceutical Phase 2 58-05-9 143 6006
10 Antibodies Phase 2
11 Antibodies, Monoclonal Phase 2
12 Immunoglobulins Phase 2
13 Antimetabolites Phase 2
14 Antimetabolites, Antineoplastic Phase 2
15 Dermatologic Agents Phase 2
16 Folic Acid Antagonists Phase 2
17 Immunosuppressive Agents Phase 2
18 Methylprednisolone acetate Phase 2
19 Methylprednisolone Hemisuccinate Phase 2
20 Nucleic Acid Synthesis Inhibitors Phase 2
21 Prednisolone acetate Phase 2
22 Prednisolone hemisuccinate Phase 2
23 Prednisolone phosphate Phase 2
24 Vitamin B Complex Phase 2
25 Folate Nutraceutical Phase 2
26 Vitamin B9 Nutraceutical Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Study to Evaluate Efficacy and Safety of Anakinra in the Treatment of Still's Disease (SJIA and AOSD) Recruiting NCT03265132 Phase 3 Placebo
2 Efficacy and Safety of Tocilizumab in Adult's Still Disease Unknown status NCT01002781 Phase 2 Tocilizumab
3 Treatment of Refractory Adult-onset Still's Disease With Anakinra: a Randomized Study Completed NCT01033656 Phase 2 anakinra;comparators
4 Therapeutic Use of Tadekinig Alfa in Adult-onset Still's Disease Completed NCT02398435 Phase 2
5 Interleukin-1 Trap to Treat Autoinflammatory Diseases Completed NCT00094900 Phase 2 IL-1 Trap
6 Canakinumab for Treatment of Adult Onset Still's Disease Recruiting NCT02204293 Phase 2 Canakinumab;Placebo Injection;Canakinumab
7 Tocilizumab in Patients With Schnitzler's Syndrome Recruiting NCT03046381 Phase 2 Tocilizumab
8 Admission of Adult-onset Still Disease Patients in the ICU Recruiting NCT03276650
9 Natural History, Genetics, and Pathophysiology of Systemic Juvenile Idiopathic Arthritis, Adult-Onset Still's Disease, and Related Conditions Recruiting NCT03510442
10 Glycosylated Ferritin in Macrophagic Activation Syndromes Recruiting NCT02143986

Search NIH Clinical Center for Adult-Onset Still's Disease

Cochrane evidence based reviews: still's disease, adult-onset

Genetic Tests for Adult-Onset Still's Disease

Anatomical Context for Adult-Onset Still's Disease

MalaCards organs/tissues related to Adult-Onset Still's Disease:

41
Testes, Liver, Lymph Node, Lung, Heart, Skin, Bone

Publications for Adult-Onset Still's Disease

Articles related to Adult-Onset Still's Disease:

(show top 50) (show all 660)
# Title Authors Year
1
Beneficial use of serum ferritin and heme oxygenase-1 as biomarkers in adult-onset Still's disease: A multicenter retrospective study. ( 29278009 )
2018
2
Impaired autophagic flux and its related inflammation in patients with adult-onset Still's disease. ( 29416600 )
2018
3
Evidence for genetic overlap between adult onset Still's disease and hereditary periodic fever syndromes. ( 29159471 )
2018
4
Biological agents in the management of adult-onset Still's disease. ( 29631071 )
2018
5
A case of adult onset Still's disease with mutations of the MEFV gene who is partially responsive to colchicine. ( 29642170 )
2018
6
Interleukin-37 is increased in adult-onset Still's disease and associated with disease activity. ( 29566725 )
2018
7
Generalized Purpura as an Atypical Skin Manifestation of Adult-onset Still's Disease in a Patient with BehAset's Disease. ( 29313056 )
2018
8
Severe Pulmonary Hypertension Due to Adult-Onset Still's Disease. ( 29468168 )
2018
9
Adult-onset Still's disease initially thought to be an odontogenic infection: A case report. ( 29733534 )
2018
10
Molecular genetic analysis for periodic fever syndromes: a supplemental role for the diagnosis of adult-onset Still's disease. ( 29909561 )
2018
11
Acute appendicitis complicated with necrotizing fasciitis in a patient with adult-onset Still's disease: A case report. ( 29384877 )
2018
12
Adult Onset Still's Disease: A Classic Presentation of a Rare Illness. ( 29906427 )
2018
13
Biological therapy of traditional therapy-resistant adult-onset Still's disease: an evidence-based review. ( 29416343 )
2018
14
Two Severe Cases of Adult-onset Still's Disease with Persistent Pruritic Eruptions. ( 29362813 )
2018
15
Early use of anakinra in adult-onset Still's disease myocarditis. ( 29291663 )
2018
16
Adult-onset Still's disease with prominent polyserositis. ( 29506437 )
2018
17
Efficacy and safety of tocilizumab with inhibition of interleukin-6 in adult-onset Still's disease: A meta-analysis. ( 29251027 )
2018
18
Adding colchicine to immunosuppressive treatments; a potential option for biologics-refractory adult-onset Still's disease. ( 29784018 )
2018
19
Complications of adult-onset Still's disease and their management. ( 29658384 )
2018
20
Efficacy of Denosumab for Osteoporosis in Two Patients with Adult-Onset Still's Disease-Denosumab Efficacy in Osteoporotic Still's Disease Patients. ( 29565301 )
2018
21
Increased Severity and Epidermal Alterations in Persistent versus Evanescent Skin lesions in Adult Onset Still's disease. ( 29787836 )
2018
22
Macrophage Activation Syndrome Associated With Adult Onset Still's Disease. ( 29938438 )
2018
23
Open-label, multicentre, dose-escalating phase II clinical trial on the safety and efficacy of tadekinig alfa (IL-18BP) in adult-onset Still's disease. ( 29472362 )
2018
24
Therapeutic innovation in adult-onset Still's disease (and other rare inflammatory disorders): how to secure evidence-based medicine? ( 29860231 )
2018
25
Highly Expression of CD11b and CD32 on Peripheral Blood Mononuclear Cells from Patients with Adult-Onset Still's Disease. ( 28106835 )
2017
26
Phosphorylated signal transducer and activator of transcription 3 in the epidermis in adult-onset Still's disease. ( 28470759 )
2017
27
Autophagy inhibition in adult-onset Still's disease: still more space for hydroxychloroquine? ( 29148405 )
2017
28
Adult-Onset Still's Disease: Is This Truly a Diagnosis of Exclusion? ( 29164007 )
2017
29
Validation of the Fautrel classification criteria for adult-onset Still's disease. ( 28760536 )
2017
30
Adult onset Still's Disease. ( 29241877 )
2017
31
A case of adult-onset Still's disease accompanied by pseudo-gray platelet syndrome. ( 29043244 )
2017
32
Utility and drawbacks of [18]F-fluorodeoxyglucose positron emission tomography in the evaluation of adult-onset Still's disease. ( 29096430 )
2017
33
Adult-onset Still's disease in a patient with psoriasis vulgaris showing inverse correlation of disease activity. ( 29083047 )
2017
34
Purulent constrictive pericarditis caused by Salmonella enteritidis in a patient with adult-onset Still's disease: A case report. ( 29390286 )
2017
35
Adult-onset Still's disease presenting with shawl sign-like eruption. ( 28925003 )
2017
36
Adult-onset Still's disease-like condition due to alcoholic hepatitis and vitamin B deficiency. ( 28691376 )
2017
37
Delay in the Diagnosis of Adult-Onset Still's Disease. ( 28690954 )
2017
38
Adult onset Still's disease-The evidence that anti-interleukin-1 treatment is effective and well-tolerated (a comprehensive literature review). ( 28757235 )
2017
39
Biologic drugs in adult onset Still's disease: a systematic review and meta-analysis of observational studies. ( 28870100 )
2017
40
Upregulation of circulating microRNA-134 in adult-onset Still's disease and its use as potential biomarker. ( 28646209 )
2017
41
Refractory Adult Onset Still's Disease. ( 29282446 )
2017
42
Response to Interleukin-1 Inhibitors in 140 Italian Patients with Adult-Onset Still's Disease: A Multicentre Retrospective Observational Study. ( 28659802 )
2017
43
New Markers for Adult-Onset Still's Disease. ( 28529117 )
2017
44
Imaging characteristics of adult onset Still's disease demonstrated with 18F-FDG PET/CT. ( 28765926 )
2017
45
Adult-onset Still's disease with atypical cutaneous manifestations. ( 28296747 )
2017
46
Diagnostic Challenge: A Report of Two Adult-Onset Still's Disease Cases. ( 29147588 )
2017
47
Rumpel-Leede phenomenon in a patient with adult-onset Still's disease. ( 28130282 )
2017
48
Inadvertent Skipping of Steroids in Septic Shock Leads to a Diagnosis of Adult Onset Still's Disease. ( 28191382 )
2017
49
Elevated circulating levels of the interferon-I^-induced chemokines are associated with disease activity and cutaneous manifestations in adult-onset Still's disease. ( 28436448 )
2017
50
A Pilot Study on Tocilizumab for Treating Refractory Adult-Onset Still's Disease. ( 29044212 )
2017

Variations for Adult-Onset Still's Disease

Expression for Adult-Onset Still's Disease

Search GEO for disease gene expression data for Adult-Onset Still's Disease.

Pathways for Adult-Onset Still's Disease

Pathways related to Adult-Onset Still's Disease according to GeneCards Suite gene sharing:

(show top 50) (show all 63)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.79 CRP CSF1 FCGR2A IL18 IL1B IL1R1
2
Show member pathways
13.6 CSF1 IL18 IL1B IL1R1 IL1RN IL6
3
Show member pathways
13.33 CSF1 IL18 IL1B IL1R1 IL6 TNF
4
Show member pathways
13.3 CSF1 IL18 IL1B IL1R1 IL1RN IL6
5
Show member pathways
13.23 CSF1 IL18 IL1B IL1R1 IL6 TNF
6
Show member pathways
12.95 IL18 IL1B IL6 MEFV TNF
7
Show member pathways
12.72 IL18 IL1B IL6 TNF
8 12.69 CSF1 IL1B IL1R1 TNF
9
Show member pathways
12.69 IL18 IL1B IL6 TNF
10
Show member pathways
12.63 IL1B IL1R1 IL6 TNF
11
Show member pathways
12.59 IL18 IL1B IL6 TNF
12
Show member pathways
12.54 IL18 IL1B IL6 TNF
13
Show member pathways
12.44 IL1B IL1R1 TNF
14
Show member pathways
12.42 IL18 IL1B IL1R1 IL6 TNF
15
Show member pathways
12.31 CRP CSF1 IL1B IL6 TNF
16
Show member pathways
12.23 IL18 IL1B IL1R1 IL6 TNF
17
Show member pathways
12.22 IL1B IL1R1 IL6 MIF TNF
18 12.2 FCGR2A IL18 IL1B IL6 TNF
19
Show member pathways
12.18 FCGR2A IL1B TNF
20
Show member pathways
12.18 IL1B IL1R1 IL6 TNF
21 12.18 IL1B IL1RN IL6 TNF
22
Show member pathways
12.14 IL1B IL6 TNF
23 12.04 IL1B IL1R1 TNF
24
Show member pathways
12.03 IL18 IL1B IL1R1 IL6
25 12.01 IL6 MIF TNF
26 12 CSF1 FCGR2A IL6 TNF
27 11.99 IL18 IL1B IL6 TNF
28 11.98 CSF1 FCGR2A IL1B IL1R1 TNF
29 11.96 CSF1 IL1B IL6 TNF
30
Show member pathways
11.94 IL18 IL1B IL1R1
31 11.89 IL1B IL1R1 IL6 TNF
32
Show member pathways
11.88 IL18 IL1B IL1R1 IL1RN IL6 TNF
33 11.87 IL1B IL6 TNF
34 11.85 IL1B IL1R1 TNF
35 11.81 IL18 IL1B IL6
36 11.8 IL18 IL1B IL1R1 TNF
37 11.75 IL1B IL6 TNF
38 11.75 CSF1 IL1B IL6 TNF
39 11.71 CSF1 IL1B IL1R1 IL6 TNF
40
Show member pathways
11.67 IL1B IL6 MIF TNF
41 11.66 IL1B IL6 TNF
42 11.61 CSF1 IL18 IL1B IL6 TNF
43 11.58 IL18 IL1B IL6 TNF
44 11.54 CSF1 IL1B IL6
45 11.51 IL1B IL6 TNF
46 11.51 FCGR2A IL1B IL1R1 IL6 MIF TNF
47 11.5 IL18 IL1B IL6 TNF
48
Show member pathways
11.48 IL1B IL1R1 TNF
49 11.48 CSF1 IL18 IL1B TNF
50 11.46 IL18 IL1B MEFV

GO Terms for Adult-Onset Still's Disease

Cellular components related to Adult-Onset Still's Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.7 CRP CSF1 FCGR2A IL18 IL1B IL1RN
2 extracellular space GO:0005615 9.56 CRP CSF1 IL18 IL1B IL1RN IL6
3 vesicle GO:0031982 9.43 IL1B IL1RN MIF
4 extracellular region GO:0005576 9.28 CRP CSF1 IL18 IL1B IL1R1 IL1RN

Biological processes related to Adult-Onset Still's Disease according to GeneCards Suite gene sharing:

(show all 39)
# Name GO ID Score Top Affiliating Genes
1 innate immune response GO:0045087 9.98 CRP CSF1 MEFV MIF
2 immune response GO:0006955 9.85 IL18 IL1B IL1R1 IL1RN IL6 TNF
3 positive regulation of protein phosphorylation GO:0001934 9.84 IL1B MIF TNF
4 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.83 IL1B IL6 TNF
5 positive regulation of DNA binding transcription factor activity GO:0051091 9.81 IL1B IL6 TNF
6 defense response to Gram-positive bacterium GO:0050830 9.8 CRP IL6 TNF
7 interleukin-1-mediated signaling pathway GO:0070498 9.79 IL1B IL1R1 IL1RN
8 positive regulation of peptidyl-serine phosphorylation GO:0033138 9.79 IL6 MIF TNF
9 cellular response to organic cyclic compound GO:0071407 9.77 IL18 IL1B TNF
10 response to glucocorticoid GO:0051384 9.75 IL1RN IL6 TNF
11 positive regulation of gene expression GO:0010628 9.73 CRP CSF1 IL18 IL1B IL6 TNF
12 positive regulation of smooth muscle cell proliferation GO:0048661 9.7 IL18 IL6 TNF
13 regulation of signaling receptor activity GO:0010469 9.7 CSF1 IL18 IL1B IL1RN IL6 MIF
14 positive regulation of cytokine secretion GO:0050715 9.68 MIF TNF
15 positive regulation of interleukin-8 production GO:0032757 9.67 IL1B TNF
16 negative regulation of myoblast differentiation GO:0045662 9.67 IL18 TNF
17 positive regulation of interleukin-6 production GO:0032755 9.67 IL1B IL6 TNF
18 positive regulation of osteoclast differentiation GO:0045672 9.66 CSF1 TNF
19 positive regulation of chemokine production GO:0032722 9.66 IL6 TNF
20 negative regulation of lipid catabolic process GO:0050995 9.65 IL1B TNF
21 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.65 IL1B TNF
22 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.65 IL18 IL1B TNF
23 positive regulation of macrophage derived foam cell differentiation GO:0010744 9.64 CSF1 IL18
24 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.63 IL1B TNF
25 positive regulation of granulocyte macrophage colony-stimulating factor production GO:0032725 9.63 IL18 IL1B
26 positive regulation of interferon-gamma production GO:0032729 9.63 IL18 IL1B TNF
27 positive regulation of chemokine biosynthetic process GO:0045080 9.61 IL1B TNF
28 interleukin-6 production GO:0032635 9.59 IL18 IL1B
29 regulation of establishment of endothelial barrier GO:1903140 9.58 IL1B TNF
30 lipopolysaccharide-mediated signaling pathway GO:0031663 9.58 IL18 IL1B TNF
31 positive regulation of fever generation GO:0031622 9.57 IL1B TNF
32 fever generation GO:0001660 9.56 IL1B IL1RN
33 positive regulation of chemokine (C-X-C motif) ligand 2 production GO:2000343 9.55 MIF TNF
34 negative regulation of interleukin-1-mediated signaling pathway GO:2000660 9.54 IL1RN IL6
35 sequestering of triglyceride GO:0030730 9.51 IL1B TNF
36 negative regulation of lipid storage GO:0010888 9.5 CRP IL6 TNF
37 cytokine-mediated signaling pathway GO:0019221 9.5 CSF1 IL18 IL1B IL1R1 IL1RN IL6
38 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.43 IL1B TNF
39 inflammatory response GO:0006954 9.28 CRP CSF1 IL18 IL1B IL1RN IL6

Molecular functions related to Adult-Onset Still's Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.65 CRP CSF1 MEFV MIF TNF
2 cytokine activity GO:0005125 9.17 CSF1 IL18 IL1B IL1RN IL6 MIF
3 interleukin-1 receptor binding GO:0005149 9.16 IL1B IL1RN
4 protease binding GO:0002020 9.13 IL1R1 MIF TNF
5 protein binding GO:0005515 10.06 CRP CSF1 FCGR2A IL18 IL1B IL1R1

Sources for Adult-Onset Still's Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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