MCID: ADL030
MIFTS: 65

Adult-Onset Still's Disease

Categories: Bone diseases, Nephrological diseases, Rare diseases

Aliases & Classifications for Adult-Onset Still's Disease

MalaCards integrated aliases for Adult-Onset Still's Disease:

Name: Adult-Onset Still's Disease 12 77 54 15 17
Adult-Onset Still Disease 12 60 74
Still's Disease, Adult-Onset 45
Adult Onset Still's Disease 12
Still's Disease Adult Onset 54
Stills Disease Adult-Onset 56
Adult Onset Still Disease 38
Wissler-Fanconi Syndrome 60
Adult Still's Disease 54
Wissler's Syndrome 74
Aosd 60

Characteristics:

Orphanet epidemiological data:

60
adult-onset still disease
Inheritance: Not applicable; Prevalence: 1-9/1000000 (France),1-9/1000000 (Japan),1-9/1000000 (Norway),1-9/100000 (Norway),1-9/100000 (Europe),1-9/1000000 (Turkey),1-9/100000 (Turkey); Age of onset: Adult; Age of death: normal life expectancy;

Classifications:



Summaries for Adult-Onset Still's Disease

NIH Rare Diseases : 54 Adult-onset Still's disease (AOSD) is an inflammatory disease characterized by high fevers, rash, sore throat, and joint pain. Several joints are often affected at the same time, and the joints are often stiff for several hours in the morning. Fevers develop each day (usually in the afternoon or evening), and the rash comes and goes with the fever. Other signs and symptoms may include abdominal pain, pleurisy, swollen lymph nodes, and weight loss. In some cases, the lungs and heart become inflamed. As it progresses, the disease may lead to chronic arthritis and other complications. The cause of AOSD is unknown, and no risk factors for the disease have been identified. It is diagnosed based on symptoms and the results of several blood tests. Blood test results may show a high white blood cell count, high C-reactive protein and ESR (measures of inflammation), high ferritin level, high fibrinogen level, and high levels of AST and ALT on liver function tests. AOSD is only diagnosed when other conditions such as infections and cancer are ruled out. Treatment aims to control inflammation, and prevent joint damage and other complications. Depending on severity and whether long-term management is needed, medications used may include non-steroidal inflammatory drugs, glucocorticoids, nonbiologic or biologic disease-modifying antirheumatic drugs (DMARDs), or other biologic agents. The long-term outlook depends on severity, whether the disease is chronic (long-lasting), and what organs or parts of the body are involved.  Of note, Still's disease which occurs in children (those under the age of 16) is known as systemic onset juvenile rheumatoid arthritis (JRA).

MalaCards based summary : Adult-Onset Still's Disease, also known as adult-onset still disease, is related to purpura and amyloidosis aa, and has symptoms including exanthema An important gene associated with Adult-Onset Still's Disease is IL18 (Interleukin 18), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Antirheumatic Agents and Interleukin 1 Receptor Antagonist Protein have been mentioned in the context of this disorder. Affiliated tissues include liver, lung and testes, and related phenotypes are arthritis and splenomegaly

Disease Ontology : 12 An arthritis that is a rare from of inflammatory arthritis characterized by fevers, rash, and joint pain.

Wikipedia : 77 Adult-onset Still''s disease (AOSD) is a form of Still''s disease, a rare systemic autoinflammatory... more...

Related Diseases for Adult-Onset Still's Disease

Diseases related to Adult-Onset Still's Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 423)
# Related Disease Score Top Affiliating Genes
1 purpura 30.8 CRP IL6 TNF
2 amyloidosis aa 30.6 CRP MEFV
3 vasculitis 30.5 CRP MEFV TNF
4 endocarditis 30.5 CRP IL6 TNF
5 cardiac tamponade 30.4 IL1RN TNFRSF1A
6 polyarteritis nodosa 30.4 CRP IL6 MEFV
7 meningitis 30.4 CRP IL1B IL6 TNF
8 pustulosis of palm and sole 30.4 IL1RN TNF
9 pneumonia 30.4 CRP IL1B IL6 TNF
10 acute respiratory distress syndrome 30.3 IL1B IL6 TNF
11 interstitial lung disease 30.3 IL1B IL6 TNF
12 systemic onset juvenile idiopathic arthritis 30.2 IL18 MEFV MIF TNF
13 fasciitis 30.2 IL18 IL6 TNF
14 necrotizing fasciitis 30.2 IL18 IL1RN IL6
15 inflammatory myopathy with abundant macrophages 30.2 MEFV TNFRSF1A
16 lymphadenitis 30.2 IL18 IL1B TNF
17 melioidosis 30.2 IL18 IL6 TNF
18 cytomegalovirus infection 30.1 IL1B IL6 TNF
19 pleurisy 30.1 CRP MEFV TNF
20 pharyngitis 30.0 CRP IL1B MEFV
21 colitis 30.0 IL1B IL6 TNF
22 rheumatoid arthritis, systemic juvenile 30.0 IL1R1 IL6 MIF
23 drug reaction with eosinophilia and systemic symptoms 30.0 CRP TNF
24 pericardial effusion 30.0 CRP IL6 TNFRSF1A
25 spondylitis 29.8 CRP IL1RN IL6 TNF
26 chikungunya 29.8 IL1B IL6 TNF
27 appendicitis 29.8 CRP IL1B IL6 TNF
28 lyme disease 29.8 CRP IL1B IL6 TNF
29 aseptic meningitis 29.8 CSF1 IL1B IL1R1 IL1RN TNF
30 ulcerative colitis 29.7 CRP IL1B IL6 TNF
31 spondylarthropathy 29.7 CSF1 TNF TNFRSF1A
32 cryopyrin-associated periodic syndrome 29.7 CRP IL1R1 IL1RN IL6
33 osteomyelitis 29.6 IL1B IL1RN IL6 TNF
34 glomerulonephritis 29.6 CSF1 IL1B MIF
35 juvenile rheumatoid arthritis 29.6 CRP IL18 IL1B IL1R1 IL1RN IL6
36 chlamydia 29.5 CRP IL1B IL6 TNF
37 schnitzler syndrome 29.5 CRP IL18 IL1B IL1R1 IL1RN
38 sarcoidosis 1 29.5 IL18 IL1B TNF
39 familial mediterranean fever 29.3 CRP IL1B IL1RN MEFV TNF TNFRSF1A
40 psoriatic arthritis 29.2 CRP IL1B IL6 TNF TNFRSF1A
41 arthritis 29.2 CSF1 IL18 IL1B IL1RN IL6 MIF
42 osteoporosis 29.1 CSF1 IL1B IL1RN IL6 TNF
43 diabetes mellitus 29.1 CRP IL1B IL1RN IL6 TNF
44 pericarditis 29.0 CRP IL1B IL1RN IL6 MEFV TNF
45 systemic lupus erythematosus 28.9 CRP CSF1 IL18 IL1B IL6 TNF
46 rheumatoid arthritis 27.6 CRP CSF1 IL18 IL1B IL1R1 IL1RN
47 wissler's syndrome 12.1
48 macrophage activation syndrome 10.6
49 hepatitis 10.6
50 lymphoma 10.5

Graphical network of the top 20 diseases related to Adult-Onset Still's Disease:



Diseases related to Adult-Onset Still's Disease

Symptoms & Phenotypes for Adult-Onset Still's Disease

Human phenotypes related to Adult-Onset Still's Disease:

60 33 (show all 29)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 arthritis 60 33 hallmark (90%) Very frequent (99-80%) HP:0001369
2 splenomegaly 60 33 hallmark (90%) Very frequent (99-80%) HP:0001744
3 hepatomegaly 60 33 hallmark (90%) Very frequent (99-80%) HP:0002240
4 fever 60 33 hallmark (90%) Very frequent (99-80%) HP:0001945
5 fatigue 60 33 hallmark (90%) Very frequent (99-80%) HP:0012378
6 joint swelling 60 33 hallmark (90%) Very frequent (99-80%) HP:0001386
7 arthralgia 60 33 hallmark (90%) Very frequent (99-80%) HP:0002829
8 pruritus 60 33 hallmark (90%) Very frequent (99-80%) HP:0000989
9 leukocytosis 60 33 hallmark (90%) Very frequent (99-80%) HP:0001974
10 erythema 60 33 hallmark (90%) Very frequent (99-80%) HP:0010783
11 skin rash 60 33 hallmark (90%) Very frequent (99-80%) HP:0000988
12 elevated c-reactive protein level 60 33 hallmark (90%) Very frequent (99-80%) HP:0011227
13 restrictive ventilatory defect 60 33 hallmark (90%) Very frequent (99-80%) HP:0002091
14 elevated erythrocyte sedimentation rate 60 33 hallmark (90%) Very frequent (99-80%) HP:0003565
15 neutrophilia 60 33 hallmark (90%) Very frequent (99-80%) HP:0011897
16 abdominal pain 60 33 frequent (33%) Frequent (79-30%) HP:0002027
17 myalgia 60 33 frequent (33%) Frequent (79-30%) HP:0003326
18 pericarditis 60 33 frequent (33%) Frequent (79-30%) HP:0001701
19 pleuritis 60 33 frequent (33%) Frequent (79-30%) HP:0002102
20 generalized lymphadenopathy 60 33 frequent (33%) Frequent (79-30%) HP:0008940
21 hepatitis 60 33 occasional (7.5%) Occasional (29-5%) HP:0012115
22 bone marrow hypocellularity 60 33 occasional (7.5%) Occasional (29-5%) HP:0005528
23 elevated hepatic transaminase 60 33 occasional (7.5%) Occasional (29-5%) HP:0002910
24 myocarditis 60 33 occasional (7.5%) Occasional (29-5%) HP:0012819
25 recurrent pharyngitis 60 33 occasional (7.5%) Occasional (29-5%) HP:0100776
26 meningitis 60 33 occasional (7.5%) Occasional (29-5%) HP:0001287
27 cartilage destruction 60 33 occasional (7.5%) Occasional (29-5%) HP:0100773
28 abnormal circulating lipid concentration 33 occasional (7.5%) HP:0003119
29 abnormality of lipid metabolism 60 Occasional (29-5%)

UMLS symptoms related to Adult-Onset Still's Disease:


exanthema

MGI Mouse Phenotypes related to Adult-Onset Still's Disease:

47 (show all 15)
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.22 CRP CSF1 IL18 IL1B IL1R1 IL1RN
2 immune system MP:0005387 10.2 CRP CSF1 IL18 IL1B IL1R1 IL1RN
3 cardiovascular system MP:0005385 10.19 CRP CSF1 IL18 IL1B IL1R1 IL1RN
4 hematopoietic system MP:0005397 10.19 CSF1 IL18 IL1B IL1R1 IL1RN IL6
5 cellular MP:0005384 10.18 CSF1 IL18 IL1R1 IL1RN IL6 MEFV
6 growth/size/body region MP:0005378 10.16 CSF1 IL18 IL1B IL1R1 IL1RN IL6
7 integument MP:0010771 10.09 CSF1 IL18 IL1B IL1R1 IL1RN IL6
8 mortality/aging MP:0010768 10.02 CSF1 IL18 IL1B IL1R1 IL1RN IL6
9 adipose tissue MP:0005375 9.95 IL18 IL1R1 IL6 TNF TNFRSF1A
10 liver/biliary system MP:0005370 9.88 CSF1 IL1R1 IL6 MEFV TNF TNFRSF1A
11 muscle MP:0005369 9.8 CSF1 IL18 IL1R1 IL6 TNF TNFRSF1A
12 nervous system MP:0003631 9.76 CSF1 IL18 IL1B IL1R1 IL6 MIF
13 neoplasm MP:0002006 9.73 IL1B IL1R1 IL6 MIF TNF TNFRSF1A
14 skeleton MP:0005390 9.56 CSF1 IL1B IL1R1 IL1RN IL6 MEFV
15 vision/eye MP:0005391 9.1 CSF1 IL18 IL1R1 IL6 TNF TNFRSF1A

Drugs & Therapeutics for Adult-Onset Still's Disease

Drugs for Adult-Onset Still's Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 29)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Antirheumatic Agents Phase 3,Phase 2
2 Interleukin 1 Receptor Antagonist Protein Phase 3,Phase 2
3
Leflunomide Approved, Investigational Phase 2 75706-12-6 3899
4
leucovorin Approved Phase 2 58-05-9 143 6006
5
Azathioprine Approved Phase 2 446-86-6 2265
6
Methotrexate Approved Phase 2 1959-05-2, 59-05-2 126941
7
Methylprednisolone hemisuccinate Approved Phase 2 2921-57-5
8
Prednisolone phosphate Approved, Vet_approved Phase 2 302-25-0
9
Prednisolone Approved, Vet_approved Phase 2 50-24-8 5755
10
Methylprednisolone Approved, Vet_approved Phase 2 83-43-2 6741
11
Rilonacept Approved, Investigational Phase 2 501081-76-1 104924
12
Folic Acid Approved, Nutraceutical, Vet_approved Phase 2 59-30-3 6037
13
Prednisolone hemisuccinate Experimental Phase 2 2920-86-7
14 Immunoglobulins Phase 2
15 Antibodies Phase 2
16 Antibodies, Monoclonal Phase 2
17 Dermatologic Agents Phase 2
18 Folic Acid Antagonists Phase 2
19 Immunosuppressive Agents Phase 2
20 Vitamin B Complex Phase 2
21 Prednisolone acetate Phase 2
22 Methylprednisolone Acetate Phase 2
23 Antimetabolites, Antineoplastic Phase 2
24 Vitamin B9 Phase 2
25 Immunologic Factors Phase 2
26 Folate Phase 2
27 Nucleic Acid Synthesis Inhibitors Phase 2
28 Antimetabolites Phase 2
29 Anti-Inflammatory Agents Phase 2

Interventional clinical trials:

(show all 11)
# Name Status NCT ID Phase Drugs
1 A Study to Evaluate Efficacy and Safety of Anakinra in the Treatment of Still's Disease (SJIA and AOSD) Recruiting NCT03265132 Phase 3 Placebo
2 Efficacy and Safety of Tocilizumab in Adult's Still Disease Unknown status NCT01002781 Phase 2 Tocilizumab
3 Treatment of Refractory Adult-onset Still's Disease With Anakinra: a Randomized Study Completed NCT01033656 Phase 2 anakinra;comparators
4 Therapeutic Use of Tadekinig Alfa in Adult-onset Still's Disease Completed NCT02398435 Phase 2
5 Interleukin-1 Trap to Treat Autoinflammatory Diseases Completed NCT00094900 Phase 2 IL-1 Trap
6 Tocilizumab in Patients With Schnitzler's Syndrome Recruiting NCT03046381 Phase 2 Tocilizumab
7 Canakinumab for Treatment of Adult Onset Still's Disease Terminated NCT02204293 Phase 2 Canakinumab;Placebo Injection;Canakinumab
8 Admission of Adult-onset Still Disease Patients in the ICU Completed NCT03276650
9 Natural History, Genetics, and Pathophysiology of Systemic Juvenile Idiopathic Arthritis, Adult-Onset Still's Disease, and Related Conditions Recruiting NCT03510442
10 Glycosylated Ferritin in Macrophagic Activation Syndromes Recruiting NCT02143986
11 Multi-center Registration Study of Adult Onset Still's Disease in Chinese Population Not yet recruiting NCT03651193

Search NIH Clinical Center for Adult-Onset Still's Disease

Cochrane evidence based reviews: still's disease, adult-onset

Genetic Tests for Adult-Onset Still's Disease

Anatomical Context for Adult-Onset Still's Disease

MalaCards organs/tissues related to Adult-Onset Still's Disease:

42
Liver, Lung, Testes, Bone, Heart, Lymph Node, Thyroid

Publications for Adult-Onset Still's Disease

Articles related to Adult-Onset Still's Disease:

(show top 50) (show all 848)
# Title Authors Year
1
Successful treatment with anakinra of an HIV-associated immune reconstitution inflammatory syndrome mimicking adult-onset Still's disease. ( 30239973 )
2019
2
Case of adult-onset Still's disease with psoriasiform eruptions. ( 30144140 )
2019
3
Are the 2016 EULAR/ACR/PRINTO classification criteria for macrophage activation syndrome applicable to patients with adult-onset Still's disease? ( 30051293 )
2019
4
Biological agents in the management of adult-onset Still's disease. ( 29631071 )
2019
5
Racial/Ethnic variations in morbidity and mortality in Adult Onset Still's Disease: An analysis of national dataset. ( 31109638 )
2019
6
Efficacy of sarilumab in adult-onset Still's disease as a corticosteroid-sparing agent. ( 31056689 )
2019
7
The role of damage associated molecular pattern for pathogenesis and biomarkers in adult onset Still's disease. ( 31055973 )
2019
8
Neutrophil extracellular traps may contribute to the pathogenesis in adult-onset Still's disease. ( 31043551 )
2019
9
Histopathology and expression of the chemokines CXCL10, CXCL13, and CXCR3 and the endogenous TLR-4 ligand S100A8/A9 in lymph nodes of patients with adult-onset Still's disease. ( 31101882 )
2019
10
Cytomegalovirus Infection May Trigger Adult-Onset Still's Disease Onset or Relapses. ( 31068953 )
2019
11
Complex presentation of adult-onset Still's disease. ( 31028049 )
2019
12
Long-Term Retention Rate of Anakinra in Adult Onset Still's Disease and Predictive Factors for Treatment Response. ( 31001115 )
2019
13
An adult case of atypical familial Mediterranean fever (pyrin-associated autoinflammatory disease) similar to adult-onset Still's disease. ( 30997089 )
2019
14
Managing Adult-onset Still's disease: The effectiveness of high-dosage of corticosteroids as first-line treatment in inducing the clinical remission. Results from an observational study. ( 30985672 )
2019
15
Incidental papillary thyroid cancer diagnosis in patient with adult-onset Still's disease-like manifestations. ( 30932443 )
2019
16
Comparative study of Interleukin-18 (IL-18) serum levels in adult onset Still's disease (AOSD) and systemic onset juvenile idiopathic arthritis (sJIA) and its use as a biomarker for diagnosis and evaluation of disease activity. ( 30886992 )
2019
17
FDG PET/CT findings in adult-onset Still's disease. ( 30828734 )
2019
18
Tocilizumab for the treatment of adult-onset Still's disease. ( 30827128 )
2019
19
Correction to: Efficacy of canakinumab as first-line biologic agent in adult-onset Still's disease. ( 30803447 )
2019
20
Correction to: Proposal for a simple algorithm to differentiate adult-onset Still's disease with other fever of unknown origin causes: a longitudinal prospective study. ( 30778863 )
2019
21
Characteristics of circulating natural killer cells and their interferon-γ production in active adult-onset Still's disease. ( 30770498 )
2019
22
Adult-onset Still's disease-associated interstitial lung disease represents severe phenotype of the disease with higher rate of haemophagocytic syndrome and relapse. ( 30767871 )
2019
23
Efficacy of canakinumab as first-line biologic agent in adult-onset Still's disease. ( 30760322 )
2019
24
Adult-onset Still's disease biological treatment strategy may depend on the phenotypic dichotomy. ( 30755262 )
2019
25
Proposal for a simple algorithm to differentiate adult-onset Still's disease with other fever of unknown origin causes: a longitudinal prospective study. ( 30710221 )
2019
26
Increased neutrophil extracellular traps activate NLRP3 and inflammatory macrophages in adult-onset Still's disease. ( 30616678 )
2019
27
Refractory macrophage activation syndrome in the setting of adult-onset Still disease with hemophagocytic lymphohistiocytosis detected on skin biopsy treated with canakinumab and tacrolimus. ( 30927277 )
2019
28
Adult onset still disease associated with Endogenous lipoid pneumonia, A case report. ( 30830958 )
2019
29
Adult-onset Still's disease in a patient with psoriasis vulgaris showing inverse correlation of disease activity. ( 29083047 )
2018
30
Evidence for genetic overlap between adult onset Still's disease and hereditary periodic fever syndromes. ( 29159471 )
2018
31
Generalized Purpura as an Atypical Skin Manifestation of Adult-onset Still's Disease in a Patient with Behçet's Disease. ( 29313056 )
2018
32
Two Severe Cases of Adult-onset Still's Disease with Persistent Pruritic Eruptions. ( 29362813 )
2018
33
Molecular genetic analysis for periodic fever syndromes: a supplemental role for the diagnosis of adult-onset Still's disease. ( 29909561 )
2018
34
An atypical persistent eruption of adult-onset Still's disease with neutrophilic urticarial dermatosis-like dermal features: A case report and review of the literature. ( 29992610 )
2018
35
Tracheal, laryngeal and pulmonary mucormycosis followed by organizing pneumonia in a patient with Adult Onset Still's Disease. ( 30148059 )
2018
36
Severe Adult-Onset Still's Disease Mimicking Systemic Infection. ( 30186016 )
2018
37
Mechanisms, biomarkers and targets for adult-onset Still's disease. ( 30218025 )
2018
38
Tocilizumab in patients with adult-onset still's disease refractory to glucocorticoid treatment: a randomised, double-blind, placebo-controlled phase III trial. ( 30279267 )
2018
39
A Rare Ocular Manifestation of Adult Onset Still's Disease: Purtscher's-like Retinopathy. ( 27599266 )
2018
40
Selective IgM deficiency associated with adult-onset Still disease. ( 29625671 )
2018
41
Increased severity and epidermal alterations in persistent versus evanescent skin lesions in adult-onset Still disease. ( 29787836 )
2018
42
Cytokine levels in persistent skin lesions of adult-onset Still disease. ( 30245097 )
2018
43
Up-regulation of CD64 Expression on Monocytes in Patients With Active Adult-Onset Still Disease: A Possible Biomarker of Disease Activity. ( 30418347 )
2018
44
Adult-onset Still's Disease in a Female Patient with Schizophrenia: A Case Report and Literature Review. ( 30254808 )
2018
45
HLA-DQB1 DPB1 alleles in Japanese patients with adult-onset Still's disease. ( 30136608 )
2018
46
Adult-onset Still's disease with haemorrhagic pericarditis and tamponade preceded by acute Lyme disease. ( 30115716 )
2018
47
A comprehensive review on adult onset Still's disease. ( 30077425 )
2018
48
Adult-Onset Still's Disease: Molecular Pathophysiology and Therapeutic Advances. ( 30069732 )
2018
49
Characteristic patterns of HLA presentation and T cell differentiation in adult-onset Still's disease. ( 30052100 )
2018
50
A Case of Adult-Onset Still's Disease Caused by a Novel Splicing Mutation in TNFAIP3 Successfully Treated With Tocilizumab. ( 30022980 )
2018

Variations for Adult-Onset Still's Disease

Expression for Adult-Onset Still's Disease

Search GEO for disease gene expression data for Adult-Onset Still's Disease.

Pathways for Adult-Onset Still's Disease

Pathways related to Adult-Onset Still's Disease according to GeneCards Suite gene sharing:

(show top 50) (show all 79)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.83 CRP CSF1 IL18 IL1B IL1R1 IL1RN
2
Show member pathways
13.77 CSF1 IL18 IL1B IL1R1 IL6 TNF
3
Show member pathways
13.59 CSF1 IL18 IL1B IL1R1 IL1RN IL6
4
Show member pathways
13.46 IL18 IL1B IL1R1 IL6 TNF TNFRSF1A
5
Show member pathways
13.37 CSF1 IL18 IL1B IL1R1 IL6 TNF
6
Show member pathways
13.28 CSF1 IL18 IL1B IL1R1 IL1RN IL6
7
Show member pathways
13.26 CSF1 IL18 IL1B IL1R1 IL6 TNF
8
Show member pathways
13.07 IL18 IL1B IL6 MEFV TNF TNFRSF1A
9
Show member pathways
12.92 IL1B IL1R1 IL6 TNF TNFRSF1A
10
Show member pathways
12.85 IL18 IL1B IL6 TNF TNFRSF1A
11 12.76 CSF1 IL1B IL1R1 TNF TNFRSF1A
12
Show member pathways
12.71 IL18 IL1B IL6 TNF
13
Show member pathways
12.7 IL1B IL1R1 IL6 TNF TNFRSF1A
14
Show member pathways
12.64 IL1B IL1R1 TNF TNFRSF1A
15
Show member pathways
12.6 IL18 IL1B IL1R1 IL6 TNF
16
Show member pathways
12.57 IL1B IL1R1 TNF TNFRSF1A
17
Show member pathways
12.56 IL18 IL1B IL6 TNF
18 12.54 IL1B IL1RN TNF TNFRSF1A
19 12.36 IL1R1 IL6 TNF TNFRSF1A
20
Show member pathways
12.34 CRP CSF1 IL1B IL6 TNF
21
Show member pathways
12.32 IL1B IL1R1 IL6 MIF TNF
22
Show member pathways
12.24 IL18 IL1B IL6 TNF
23 12.23 IL18 IL1B IL6 TNF TNFRSF1A
24
Show member pathways
12.21 IL1B IL1R1 IL6 TNF
25
Show member pathways
12.2 IL1B TNF TNFRSF1A
26 12.2 IL1B IL1RN IL6 TNF
27
Show member pathways
12.17 IL1B IL6 TNF
28
Show member pathways
12.17 IL1B TNF TNFRSF1A
29 12.14 IL6 TNF TNFRSF1A
30 12.12 IL1B IL1R1 TNF TNFRSF1A
31
Show member pathways
12.08 IL18 IL1B IL1R1 IL6 TNFRSF1A
32
Show member pathways
12.05 IL18 IL1B IL1R1 IL6 TNF
33 12.04 IL6 MIF TNF
34 12.03 CSF1 IL1B IL1R1 TNF TNFRSF1A
35
Show member pathways
12.01 IL1B IL6 TNF
36 12.01 IL18 IL1B IL6 TNF
37 11.98 CSF1 IL6 TNF
38
Show member pathways
11.96 IL18 IL1B IL1R1
39
Show member pathways
11.95 IL6 TNF TNFRSF1A
40 11.95 IL1B IL1R1 IL6 MIF TNF
41 11.93 IL1B IL1R1 TNF TNFRSF1A
42 11.92 IL1B IL1R1 IL6 TNF
43 11.9 IL1B IL6 TNF
44
Show member pathways
11.88 IL18 IL1B IL1R1 IL1RN IL6 TNF
45 11.87 CSF1 IL1B IL6 TNF TNFRSF1A
46 11.83 IL18 IL1B IL6
47 11.82 IL18 IL1B IL1R1 TNF
48 11.78 IL1B IL6 TNF
49 11.78 CSF1 IL1B IL6 TNF
50 11.75 CSF1 IL1B IL1R1 IL6 TNF

GO Terms for Adult-Onset Still's Disease

Cellular components related to Adult-Onset Still's Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.61 CRP CSF1 IL18 IL1B IL1RN IL6
2 vesicle GO:0031982 9.33 IL1B IL1RN MIF
3 extracellular region GO:0005576 9.32 CRP CSF1 IL18 IL1B IL1R1 IL1RN

Biological processes related to Adult-Onset Still's Disease according to GeneCards Suite gene sharing:

(show top 50) (show all 54)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 9.95 CRP CSF1 IL18 IL1B IL6 TNF
2 positive regulation of protein phosphorylation GO:0001934 9.89 IL1B MIF TNF
3 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 9.89 IL1B IL1RN TNF TNFRSF1A
4 cellular response to lipopolysaccharide GO:0071222 9.88 IL1B IL1RN IL6 TNF
5 positive regulation of DNA-binding transcription factor activity GO:0051091 9.86 IL1B IL6 TNF
6 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.86 IL18 IL1B IL6 TNF
7 defense response to Gram-positive bacterium GO:0050830 9.85 CRP IL6 TNF
8 positive regulation of JNK cascade GO:0046330 9.85 IL1B IL1RN TNF
9 positive regulation of peptidyl-serine phosphorylation GO:0033138 9.84 IL6 MIF TNF
10 positive regulation of inflammatory response GO:0050729 9.83 IL18 TNF TNFRSF1A
11 cellular response to organic cyclic compound GO:0071407 9.82 IL18 IL1B TNF
12 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.82 IL18 IL6 TNFRSF1A
13 positive regulation of smooth muscle cell proliferation GO:0048661 9.8 IL18 IL6 TNF
14 positive regulation of interleukin-6 production GO:0032755 9.8 IL1B IL1RN IL6 TNF
15 regulation of signaling receptor activity GO:0010469 9.8 CSF1 IL18 IL1B IL1RN IL6 MIF
16 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.79 IL18 IL1B TNF
17 interleukin-1-mediated signaling pathway GO:0070498 9.78 IL1B IL1R1 IL1RN
18 lipopolysaccharide-mediated signaling pathway GO:0031663 9.74 IL18 IL1B TNF
19 positive regulation of cytokine secretion GO:0050715 9.72 MIF TNF
20 negative regulation of neurogenesis GO:0050768 9.72 IL1B IL6 TNF
21 positive regulation of interleukin-8 production GO:0032757 9.71 IL1B TNF
22 negative regulation of myoblast differentiation GO:0045662 9.71 IL18 TNF
23 positive regulation of glial cell proliferation GO:0060252 9.71 IL1B IL6 TNF
24 positive regulation of interferon-gamma production GO:0032729 9.71 IL18 IL1B IL1R1 TNF
25 positive regulation of osteoclast differentiation GO:0045672 9.7 CSF1 TNF
26 positive regulation of chemokine production GO:0032722 9.7 IL6 TNF
27 negative regulation of lipid catabolic process GO:0050995 9.7 IL1B TNF
28 positive regulation of macrophage derived foam cell differentiation GO:0010744 9.69 CSF1 IL18
29 regulation of I-kappaB kinase/NF-kappaB signaling GO:0043122 9.69 IL1B TNF
30 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.69 IL1B TNF
31 response to glucocorticoid GO:0051384 9.69 IL1RN IL6 TNF
32 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.68 IL1B TNF
33 positive regulation of granulocyte macrophage colony-stimulating factor production GO:0032725 9.68 IL18 IL1B
34 positive regulation of ceramide biosynthetic process GO:2000304 9.67 TNF TNFRSF1A
35 death-inducing signaling complex assembly GO:0071550 9.66 TNF TNFRSF1A
36 positive regulation of chemokine biosynthetic process GO:0045080 9.66 IL1B TNF
37 interleukin-6 production GO:0032635 9.65 IL18 IL1B
38 negative regulation of interleukin-1-mediated signaling pathway GO:2000660 9.64 IL1RN IL6
39 positive regulation of chemokine (C-X-C motif) ligand 2 production GO:2000343 9.63 MIF TNF
40 positive regulation of fever generation GO:0031622 9.63 IL1B TNF
41 negative regulation of lipid storage GO:0010888 9.63 CRP IL6 TNF
42 sequestering of triglyceride GO:0030730 9.61 IL1B TNF
43 regulation of establishment of endothelial barrier GO:1903140 9.61 IL1B TNF TNFRSF1A
44 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.6 IL1B TNF
45 cytokine-mediated signaling pathway GO:0019221 9.56 CSF1 IL18 IL1B IL1R1 IL1RN IL6
46 positive regulation of T-helper 1 cell cytokine production GO:2000556 9.54 IL18 IL1B IL1R1
47 positive regulation of neuroinflammatory response GO:0150078 9.46 IL18 IL1B IL6 TNF
48 carboxylic acid metabolic process GO:0019752 9.4 MIF
49 inflammatory response GO:0006954 9.36 CRP CSF1 IL18 IL1B IL1R1 IL1RN
50 positive regulation of JUN kinase activity GO:0043507 9.28 TNF

Molecular functions related to Adult-Onset Still's Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.72 CRP CSF1 MEFV MIF TNF
2 cytokine activity GO:0005125 9.17 CSF1 IL18 IL1B IL1RN IL6 MIF
3 interleukin-1 receptor binding GO:0005149 9.16 IL1B IL1RN
4 protease binding GO:0002020 9.13 IL1R1 MIF TNF
5 protein binding GO:0005515 10 CRP CSF1 IL18 IL1B IL1R1 IL1RN

Sources for Adult-Onset Still's Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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