MCID: ADL056
MIFTS: 22

Adult Pineal Parenchymal Tumor

Categories: Cancer diseases, Endocrine diseases

Aliases & Classifications for Adult Pineal Parenchymal Tumor

MalaCards integrated aliases for Adult Pineal Parenchymal Tumor:

Name: Adult Pineal Parenchymal Tumor 12 15 73
Adult Pineal Parenchymal Neoplasm 12

Classifications:



External Ids:

Disease Ontology 12 DOID:5031
NCIt 50 C8273
UMLS 73 C0280794

Summaries for Adult Pineal Parenchymal Tumor

MalaCards based summary : Adult Pineal Parenchymal Tumor, also known as adult pineal parenchymal neoplasm, is related to murray valley encephalitis and adult pineoblastoma. An important gene associated with Adult Pineal Parenchymal Tumor is PDE4DIP (Phosphodiesterase 4D Interacting Protein), and among its related pathways/superpathways are Mitotic Prophase and Translational Control. The drugs Immunologic Factors and Antibodies, Monoclonal have been mentioned in the context of this disorder. Affiliated tissues include pineal, brain and liver.

Related Diseases for Adult Pineal Parenchymal Tumor

Diseases related to Adult Pineal Parenchymal Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 murray valley encephalitis 9.7 DICER1 DROSHA
2 adult pineoblastoma 9.5 DICER1 DROSHA PDE4DIP

Symptoms & Phenotypes for Adult Pineal Parenchymal Tumor

Drugs & Therapeutics for Adult Pineal Parenchymal Tumor

Drugs for Adult Pineal Parenchymal Tumor (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 17)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Immunologic Factors Phase 1, Phase 2
2 Antibodies, Monoclonal Phase 1, Phase 2
3 Immunoglobulins Phase 1, Phase 2
4 Antibodies Phase 1, Phase 2
5
Irinotecan Approved, Investigational Phase 1 100286-90-6, 97682-44-5 60838
6
Iodine Approved, Investigational Phase 1 7553-56-2 807
7
Carmustine Approved, Investigational Phase 1 154-93-8 2578
8
Entinostat Investigational Phase 1 209783-80-2
9 Topoisomerase Inhibitors Phase 1
10 Alkylating Agents Phase 1
11 topoisomerase I inhibitors Phase 1
12 cadexomer iodine Phase 1
13 Antineoplastic Agents, Phytogenic Phase 1
14 Antineoplastic Agents, Alkylating Phase 1
15 Liver Extracts Phase 1
16 Histone Deacetylase Inhibitors Phase 1
17 Cola Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Radiolabeled Monoclonal Antibody Therapy in Treating Patients With Primary or Metastatic Brain Tumors Completed NCT00003461 Phase 1, Phase 2
2 Stereotactic Radiosurgery in Treating Patients With Brain Tumors Completed NCT00019578 Phase 1
3 Radiolabeled Monoclonal Antibody Therapy After Radiation Therapy in Treating Patients With Primary Brain Tumors Completed NCT00003484 Phase 1 carmustine;irinotecan hydrochloride
4 MS-275 in Treating Patients With Advanced Solid Tumors or Lymphoma Completed NCT00020579 Phase 1 entinostat
5 Study of Genes and Environment in Patients With Cancer in East Anglia, Trent, or West Midlands Regions of the United Kingdom Unknown status NCT00757614
6 Decision Making About Participating in Pharmacokinetic Studies in Patients Enrolled in a Phase I Treatment Clinical Trial Completed NCT00890435
7 Perfusion Magnetic Resonance Imaging in Measuring the Growth of Blood Vessels in Newly Diagnosed Brain Tumors Withdrawn NCT00005790 Not Applicable

Search NIH Clinical Center for Adult Pineal Parenchymal Tumor

Genetic Tests for Adult Pineal Parenchymal Tumor

Anatomical Context for Adult Pineal Parenchymal Tumor

MalaCards organs/tissues related to Adult Pineal Parenchymal Tumor:

41
Pineal, Brain, Liver

Publications for Adult Pineal Parenchymal Tumor

Variations for Adult Pineal Parenchymal Tumor

Expression for Adult Pineal Parenchymal Tumor

Search GEO for disease gene expression data for Adult Pineal Parenchymal Tumor.

Pathways for Adult Pineal Parenchymal Tumor

Pathways related to Adult Pineal Parenchymal Tumor according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.78 DICER1 DROSHA
2 11.24 DICER1 DROSHA
3
Show member pathways
9.83 DICER1 DROSHA

GO Terms for Adult Pineal Parenchymal Tumor

Biological processes related to Adult Pineal Parenchymal Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 RNA phosphodiester bond hydrolysis, endonucleolytic GO:0090502 9.37 DICER1 DROSHA
2 gene silencing by RNA GO:0031047 9.32 DICER1 DROSHA
3 RNA phosphodiester bond hydrolysis GO:0090501 9.26 DICER1 DROSHA
4 miRNA metabolic process GO:0010586 9.16 DICER1 DROSHA
5 pre-miRNA processing GO:0031054 8.96 DICER1 DROSHA
6 production of siRNA involved in RNA interference GO:0030422 8.62 DICER1 DROSHA

Molecular functions related to Adult Pineal Parenchymal Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nuclease activity GO:0004518 9.32 DICER1 DROSHA
2 endonuclease activity GO:0004519 9.26 DICER1 DROSHA
3 double-stranded RNA binding GO:0003725 9.16 DICER1 DROSHA
4 endoribonuclease activity GO:0004521 8.96 DICER1 DROSHA
5 ribonuclease III activity GO:0004525 8.62 DICER1 DROSHA

Sources for Adult Pineal Parenchymal Tumor

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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