MCID: ADL025
MIFTS: 20

Adult Pineoblastoma

Categories: Cancer diseases, Endocrine diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Adult Pineoblastoma

MalaCards integrated aliases for Adult Pineoblastoma:

Name: Adult Pineoblastoma 12 15 70

Classifications:



External Ids:

Disease Ontology 12 DOID:6648
NCIt 50 C8292
UMLS 70 C0281332

Summaries for Adult Pineoblastoma

MalaCards based summary : Adult Pineoblastoma is related to hydrocephalus and pineoblastoma. An important gene associated with Adult Pineoblastoma is ZNF789 (Zinc Finger Protein 789). The drugs Fentanyl and Donepezil have been mentioned in the context of this disorder. Affiliated tissues include brain, pineal and liver.

Related Diseases for Adult Pineoblastoma

Diseases in the Pineoblastoma family:

Adult Pineoblastoma

Diseases related to Adult Pineoblastoma via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 hydrocephalus 10.1
2 pineoblastoma 10.1
3 obstructive hydrocephalus 9.9
4 pineal parenchymal tumor of intermediate differentiation 9.8 ZNF789 ACOT6
5 hydrolethalus syndrome 1 9.5 PDE4DIP NBPF26
6 adult pineal parenchymal tumor 8.5 ZNF789 SEC22B PDE4DIP NBPF26 DCHS2 ACOT6

Graphical network of the top 20 diseases related to Adult Pineoblastoma:



Diseases related to Adult Pineoblastoma

Symptoms & Phenotypes for Adult Pineoblastoma

Drugs & Therapeutics for Adult Pineoblastoma

Drugs for Adult Pineoblastoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 67)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 3 437-38-7 3345
2
Donepezil Approved Phase 3 120014-06-4 3152
3 Pancreatic Polypeptide Investigational Phase 3 59763-91-6
4 Analgesics Phase 3
5 Nootropic Agents Phase 3
6 Cola Phase 3
7 Narcotics Phase 3
8 Anesthetics Phase 3
9 Liver Extracts Phase 3
10 Anesthetics, Intravenous Phase 3
11 Anesthetics, General Phase 3
12 Analgesics, Opioid Phase 3
13 Cholinesterase Inhibitors Phase 3
14 Neurotransmitter Agents Phase 3
15 Cholinergic Agents Phase 3
16
Levetiracetam Approved Phase 2 102767-28-2 441341
17
Pregabalin Approved, Investigational Phase 2 148553-50-8 5486971
18 Psychotropic Drugs Phase 2
19 Anti-Anxiety Agents Phase 2
20 Hormones Phase 2
21 Anticonvulsants Phase 2
22 calcium channel blockers Phase 2
23 Calcium, Dietary Phase 2
24 Ginkgo Phase 2
25
Calcium Nutraceutical Phase 2 7440-70-2 271
26
Verteporfin Approved, Investigational Phase 1 129497-78-5
27
Trioxsalen Approved Phase 1 3902-71-4 5585
28
Clotrimazole Approved, Vet_approved Phase 1 23593-75-1 2812
29
Miconazole Approved, Investigational, Vet_approved Phase 1 22916-47-8 4189
30
Sirolimus Approved, Investigational Phase 1 53123-88-9 5284616 6436030
31
Temozolomide Approved, Investigational Phase 1 85622-93-1 5394
32
Bortezomib Approved, Investigational Phase 1 179324-69-7 387447 93860
33
Thiotepa Approved, Investigational Phase 1 52-24-4 5453
34
Lenograstim Approved, Investigational Phase 1 135968-09-1
35
Carboplatin Approved Phase 1 41575-94-4 10339178 498142 38904
36
Paclitaxel Approved, Vet_approved Phase 1 33069-62-4 36314
37
Somatostatin Approved, Investigational Phase 1 51110-01-1, 38916-34-6 53481605
38
Docetaxel Approved, Investigational Phase 1 114977-28-5 148124
39
Thalidomide Approved, Investigational, Withdrawn Phase 1 50-35-1 5426
40
Mechlorethamine Approved, Investigational Phase 1 51-75-2 4033
41
Melphalan Approved Phase 1 148-82-3 4053 460612
42
Calcitriol Approved, Nutraceutical Phase 1 32222-06-3 134070 5280453
43
Phenylalanine Approved, Investigational, Nutraceutical Phase 1 63-91-2 6140
44 Photosensitizing Agents Phase 1
45 Dihematoporphyrin Ether Phase 1
46 Dermatologic Agents Phase 1
47 Mitogens Phase 1
48 Anti-Bacterial Agents Phase 1
49 Antibiotics, Antitubercular Phase 1
50 Dialysis Solutions Phase 1

Interventional clinical trials:

(show all 18)
# Name Status NCT ID Phase Drugs
1 A Randomized, Double-blind, Placebo-controlled Multi-center Study to Evaluate the Safety and Efficacy of Fentanyl Sublingual Spray (Fentanyl SL Spray) for the Treatment of Breakthrough Cancer Pain Completed NCT00538850 Phase 3 Fentanyl sublingual spray;Placebo
2 Phase III Double Blind, Placebo Controlled Study of Donepezil in the Irradiated Brain Completed NCT00369785 Phase 3 donepezil hydrochloride;Placebo
3 Levetiracetam and Pregabalin for Monotherapy in Patients With Brain Tumors and Seizures. A Phase II Randomized Study. Completed NCT00629889 Phase 2 levetiracetam;pregabalin
4 Donepezil and EGb761 in Improving Neurocognitive Function in Patients Who Have Previously Undergone Radiation Therapy for Primary Brain Tumor or Brain Metastases Completed NCT00070161 Phase 2 donepezil hydrochloride
5 Photodynamic Therapy For Childhood Brain Tumors, A Phase I Study Unknown status NCT00002647 Phase 1 verteporfin
6 A Pilot Feasibility, Dose-Escalation Study Using Intracerebral Microdialysis to Assess the Neuropharmacodynamics of Temsirolimus in Patients With Primary or Metastatic Brain Tumors Completed NCT00784914 Phase 1 temsirolimus
7 A Phase I Study of Bortezomib and Temozolomide in Patients With Refractory Solid Tumors Completed NCT00544284 Phase 1 bortezomib;temozolomide
8 Dose Escalation of Temozolomide in Combination With Thiotepa and Carboplatin With Autologous Stem Cell Rescue in Patients With Malignant Brain Tumors With Minimal Residual Disease Completed NCT00025558 Phase 1 carboplatin;temozolomide;thiotepa
9 A PHASE I STUDY OF THE COMBINATION OF CAI AND PACLITAXEL IN ADULT PATIENTS WITH REFRACTORY CANCERS OR LYMPHOMA Completed NCT00019019 Phase 1 carboxyamidotriazole;paclitaxel
10 A Phase I, Open-Label, Maximum Tolerated Single-Cycle and Four-Cycle Dose-Finding Study to Evaluation the Safety and Tolerability of 90Y-SMT 487 Administered by Intravenous Infusion to Subjects With Refractory Somatostatin-Receptor Positive Tumors Completed NCT00006368 Phase 1
11 Phase I Pharmacokinetic Trial of Thalidomide and Docetaxel: A Regimen Based on Anti-Angiogenic Therapeutic Principles Completed NCT00049296 Phase 1 docetaxel;thalidomide
12 A Phase I Trial of Subcutaneous And/Or Oral Calcitriol [(1,25-COH)2D3] and Carboplatin in Advanced Solid Tumors Completed NCT00008086 Phase 1 carboplatin
13 Intra-Arterial Melphalan (L-Phenylalanine Mustard) Administered in Conjunction With Osmotic Blood-Brain Barrier Disruption in Patients With Brain Malignancies: A Phase I Study Terminated NCT00253721 Phase 1 Melphalan
14 Temozolomide Induced Changes in Semen/Sperm Analysis in Men With Newly Diagnosed, Progressive or Recurrent Primary Malignant Brain Tumors Completed NCT00499798
15 Identification of Genes Involved in the Pathogenesis of Gliomas by Transcriptome Analysis Completed NCT00967200
16 San Francisco Bay Area Adult Glioma Prognosis Study Protocol Completed NCT01009307
17 Prospective Study on the Short-Term Adverse Effects From Gamma Knife Radiosurgery Completed NCT00255671
18 Perfusion Magnetic Resonance Imaging of Brain Tumors: Correlation With Indicators of Angiogenesis Withdrawn NCT00005790

Search NIH Clinical Center for Adult Pineoblastoma

Genetic Tests for Adult Pineoblastoma

Anatomical Context for Adult Pineoblastoma

MalaCards organs/tissues related to Adult Pineoblastoma:

40
Brain, Pineal, Liver

Publications for Adult Pineoblastoma

Articles related to Adult Pineoblastoma:

# Title Authors PMID Year
1
A Case Report of Adult Pineoblastoma Occurring in a Pregnant Woman. 61
31092461 2019
2
Recurrent homozygous deletion of DROSHA and microduplication of PDE4DIP in pineoblastoma. 61
30030436 2018
3
Complete regression of adult pineoblastoma following radiotherapy: A case report and review of the literature. 61
26622845 2015
4
Management and survival of pineoblastoma: an analysis of 34 adults from the brain tumor registry of Japan. 61
15782004 2005

Variations for Adult Pineoblastoma

Expression for Adult Pineoblastoma

Search GEO for disease gene expression data for Adult Pineoblastoma.

Pathways for Adult Pineoblastoma

GO Terms for Adult Pineoblastoma

Sources for Adult Pineoblastoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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