MCID: ADL025
MIFTS: 26

Adult Pineoblastoma

Categories: Cancer diseases, Endocrine diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Adult Pineoblastoma

MalaCards integrated aliases for Adult Pineoblastoma:

Name: Adult Pineoblastoma 12 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:6648
NCIt 50 C8292
UMLS 73 C0281332

Summaries for Adult Pineoblastoma

MalaCards based summary : Adult Pineoblastoma is related to pineoblastoma and murray valley encephalitis. An important gene associated with Adult Pineoblastoma is PDE4DIP (Phosphodiesterase 4D Interacting Protein), and among its related pathways/superpathways are Mitotic Prophase and Translational Control. The drugs Fentanyl and Donepezil have been mentioned in the context of this disorder. Affiliated tissues include brain, liver and bone.

Related Diseases for Adult Pineoblastoma

Diseases in the Pineoblastoma family:

Adult Pineoblastoma

Diseases related to Adult Pineoblastoma via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 pineoblastoma 9.9
2 murray valley encephalitis 9.7 DICER1 DROSHA
3 adult pineal parenchymal tumor 9.5 DICER1 DROSHA PDE4DIP

Symptoms & Phenotypes for Adult Pineoblastoma

Drugs & Therapeutics for Adult Pineoblastoma

Drugs for Adult Pineoblastoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 95)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 3 437-38-7 3345
2
Donepezil Approved Phase 3,Phase 2 120014-06-4 3152
3 Pancreatic Polypeptide Investigational Phase 3,Phase 1 59763-91-6
4 Cola Phase 3,Phase 1
5 Central Nervous System Depressants Phase 3,Phase 2
6 Adjuvants, Anesthesia Phase 3
7 Liver Extracts Phase 3,Phase 1
8 Anesthetics, Intravenous Phase 3
9 Analgesics, Opioid Phase 3
10 Peripheral Nervous System Agents Phase 3,Phase 2
11 Anesthetics, General Phase 3
12 Analgesics Phase 3,Phase 2
13 Narcotics Phase 3
14 Anesthetics Phase 3
15 Neurotransmitter Agents Phase 3,Phase 2
16 Nootropic Agents Phase 3,Phase 2
17 Cholinergic Agents Phase 3,Phase 2
18 Cholinesterase Inhibitors Phase 3,Phase 2
19
Temozolomide Approved, Investigational Phase 1, Phase 2 85622-93-1 5394
20
Dacarbazine Approved, Investigational Phase 1, Phase 2 4342-03-4 5351166
21 Piracetam Approved, Investigational Phase 2 7491-74-9
22
Pregabalin Approved, Illicit, Investigational Phase 2 148553-50-8 5486971
23
Carboplatin Approved Phase 1, Phase 2 41575-94-4 10339178 38904 498142
24
Melphalan Approved Phase 1, Phase 2 148-82-3 4053 460612
25
Mannitol Approved, Investigational Phase 1, Phase 2 69-65-8 453 6251
26
Mechlorethamine Approved, Investigational Phase 1, Phase 2 51-75-2 4033
27 Etiracetam Investigational Phase 2 33996-58-6
28 Alkylating Agents Phase 1, Phase 2,Phase 2
29 Anti-Retroviral Agents Phase 1, Phase 2
30 Antineoplastic Agents, Alkylating Phase 1, Phase 2,Phase 2
31 Anti-Infective Agents Phase 1, Phase 2,Phase 2
32 JM 3100 Phase 1, Phase 2
33 Anti-HIV Agents Phase 1, Phase 2
34 Antiviral Agents Phase 1, Phase 2
35 Anticonvulsants Phase 2,Phase 1
36 Psychotropic Drugs Phase 2
37 Anti-Anxiety Agents Phase 2
38 Calcium, Dietary Phase 2,Phase 1
39 Neuroprotective Agents Phase 2
40 Tranquilizing Agents Phase 2
41 calcium channel blockers Phase 2,Phase 1
42 Protective Agents Phase 2,Phase 1
43 Ginkgo Phase 2
44 Anti-Bacterial Agents Phase 1, Phase 2
45 Immunologic Factors Phase 1, Phase 2
46 Immunosuppressive Agents Phase 1, Phase 2
47 alanine Phase 1, Phase 2
48 Antidotes Phase 1, Phase 2
49 diuretics Phase 1, Phase 2
50 phenylalanine Phase 1, Phase 2

Interventional clinical trials:

(show all 25)
# Name Status NCT ID Phase Drugs
1 Fentanyl Sublingual Spray in Treating Patients With Breakthrough Cancer Pain Completed NCT00538850 Phase 3 Fentanyl sublingual spray;Placebo
2 Donepezil in Treating Patients Who Have Undergone Radiation Therapy for Brain Tumors Completed NCT00369785 Phase 3 donepezil hydrochloride;Placebo
3 Plerixafor After Radiation Therapy and Temozolomide in Treating Patients With Newly Diagnosed High Grade Glioma Completed NCT01977677 Phase 1, Phase 2 temozolomide;plerixafor
4 Levetiracetam or Pregabalin in Treating Seizures in Patients Undergoing Chemotherapy and/or Radiation Therapy For Primary Brain Tumors Completed NCT00629889 Phase 2 levetiracetam;pregabalin
5 Phase II Studies Of Donepezil And Ginkgo Biloba In Irradiated Brain Tumor Completed NCT00070161 Phase 2 donepezil hydrochloride
6 Melphalan, Carboplatin, Mannitol, and Sodium Thiosulfate in Treating Patients With Recurrent or Progressive CNS Embryonal or Germ Cell Tumors Suspended NCT00983398 Phase 1, Phase 2 Carboplatin;Mannitol;Melphalan;Sodium Thiosulfate
7 Photodynamic Therapy With Porfimer Sodium in Treating Patients With Refractory Brain Tumors Unknown status NCT00002647 Phase 1 verteporfin
8 RO4929097, Temozolomide, and Radiation Therapy in Treating Patients With Newly Diagnosed Malignant Glioma Completed NCT01119599 Phase 1 Gamma-Secretase Inhibitor RO4929097;Temozolomide
9 A Feasibility, Dose-Escalation Study Using Intracerebral Microdialysis to Assess the Neuropharmacodynamics of Temsirolimus in Patients With Primary or Metastatic Brain Tumors Completed NCT00784914 Phase 1 temsirolimus
10 Bortezomib and Temozolomide in Treating Patients With Brain Tumors or Other Solid Tumors That Have Not Responded to Treatment Completed NCT00544284 Phase 1 bortezomib;temozolomide
11 Yttrium Y 90 SMT 487 in Treating Patients With Refractory or Recurrent Cancer Completed NCT00006368 Phase 1
12 Calcitriol Plus Carboplatin in Treating Patients With Advanced Solid Tumors Completed NCT00008086 Phase 1 carboplatin
13 Thalidomide and Docetaxel in Treating Patients With Advanced Cancer Completed NCT00049296 Phase 1 docetaxel;thalidomide
14 Combination Chemotherapy Followed by Peripheral Stem Cell Transplantation or Bone Marrow Transplantation in Treating Patients With Brain Cancer Completed NCT00025558 Phase 1 carboplatin;temozolomide;thiotepa
15 Carboxyamidotriazole and Paclitaxel in Treating Patients With Advanced Solid Tumors or Refractory Lymphomas Completed NCT00019019 Phase 1 carboxyamidotriazole;paclitaxel
16 Positron Emission Tomography Using Fluorine F 18 EF5 to Find Oxygen in Tumor Cells of Patients Who Are Undergoing Surgery or Biopsy for Newly Diagnosed Brain Tumors Terminated NCT00110032 Phase 1 EF5
17 Melphalan With BBBD in Treating Patients With Brain Malignancies Terminated NCT00253721 Phase 1 Melphalan
18 Study of Blood and Cheek Cell Samples From Patients With Glioma Completed NCT01009307
19 Study of Tissue Samples From Patients With Glioma or Other Brain Tumors Completed NCT00967200
20 Changes in Semen or Sperm Caused by Temozolomide in Patients With Newly Diagnosed, Progressive, or Recurrent Primary Malignant Brain Tumors Completed NCT00499798
21 Acute Side Effects in Patients Who Are Undergoing Stereotactic Radiosurgery for Brain Tumors or Other Brain Disorders Completed NCT00255671
22 Gadobutrol Versus Gadopentetate Dimeglumine or Gadobenate Dimeglumine Before DCE-MRI in Diagnosing Patients With Multiple Sclerosis, Grade II-IV Glioma, or Brain Metastases Terminated NCT02967380 Not Applicable Gadobenate Dimeglumine;Gadobutrol
23 Yoga Therapy in Treating Patients With Malignant Brain Tumors Terminated NCT01234805 Not Applicable
24 Efficacy of 68Ga-DOTATOC Positron Emission Tomography (PET) CT in Children and Young Adults With Brain Tumors Withdrawn NCT02194452 Not Applicable
25 Perfusion Magnetic Resonance Imaging in Measuring the Growth of Blood Vessels in Newly Diagnosed Brain Tumors Withdrawn NCT00005790 Not Applicable

Search NIH Clinical Center for Adult Pineoblastoma

Genetic Tests for Adult Pineoblastoma

Anatomical Context for Adult Pineoblastoma

MalaCards organs/tissues related to Adult Pineoblastoma:

41
Brain, Liver, Bone, Pineal

Publications for Adult Pineoblastoma

Articles related to Adult Pineoblastoma:

# Title Authors Year
1
Complete regression of adult pineoblastoma following radiotherapy: A case report and review of the literature. ( 26622845 )
2015

Variations for Adult Pineoblastoma

Expression for Adult Pineoblastoma

Search GEO for disease gene expression data for Adult Pineoblastoma.

Pathways for Adult Pineoblastoma

Pathways related to Adult Pineoblastoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.78 DICER1 DROSHA
2 11.24 DICER1 DROSHA
3
Show member pathways
9.83 DICER1 DROSHA

GO Terms for Adult Pineoblastoma

Biological processes related to Adult Pineoblastoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 RNA phosphodiester bond hydrolysis, endonucleolytic GO:0090502 9.37 DICER1 DROSHA
2 gene silencing by RNA GO:0031047 9.32 DICER1 DROSHA
3 RNA phosphodiester bond hydrolysis GO:0090501 9.26 DICER1 DROSHA
4 miRNA metabolic process GO:0010586 9.16 DICER1 DROSHA
5 pre-miRNA processing GO:0031054 8.96 DICER1 DROSHA
6 production of siRNA involved in RNA interference GO:0030422 8.62 DICER1 DROSHA

Molecular functions related to Adult Pineoblastoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nuclease activity GO:0004518 9.32 DICER1 DROSHA
2 endonuclease activity GO:0004519 9.26 DICER1 DROSHA
3 double-stranded RNA binding GO:0003725 9.16 DICER1 DROSHA
4 endoribonuclease activity GO:0004521 8.96 DICER1 DROSHA
5 ribonuclease III activity GO:0004525 8.62 DICER1 DROSHA

Sources for Adult Pineoblastoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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