ALI
MCID: ADL010
MIFTS: 63

Adult Respiratory Distress Syndrome (ALI)

Categories: Blood diseases, Cardiovascular diseases, Rare diseases, Respiratory diseases

Aliases & Classifications for Adult Respiratory Distress Syndrome

MalaCards integrated aliases for Adult Respiratory Distress Syndrome:

Name: Adult Respiratory Distress Syndrome 12 52 15 32
Respiratory Distress Syndrome, Adult 74 52 43 71
Ards 12 52 15 62
Non-Cardiogenic Pulmonary Edema 12 52 71
Acute Lung Injury 52 58 17
Acute Respiratory Distress Syndrome 52 17
Shock Lung 12 52
Increased-Permeability Pulmonary Edema 52
Respiratory Distress Syndrome Adult 54
Acute Respiratory Distress 54
Stiff Lung 52
Adult Rds 12
Ali 52

Characteristics:

Orphanet epidemiological data:

58
acute lung injury
Prevalence: 1-5/10000 (Europe);

Classifications:

Orphanet: 58  
Rare respiratory diseases


External Ids:

Disease Ontology 12 DOID:11394
MeSH 43 D012128
NCIt 49 C3353
SNOMED-CT 67 67782005
ICD10 32 J80
MESH via Orphanet 44 D055371
UMLS via Orphanet 72 C0242488
Orphanet 58 ORPHA178320
UMLS 71 C0035222 C3241936

Summaries for Adult Respiratory Distress Syndrome

NIH Rare Diseases : 52 Acute respiratory distress syndrome (ARDS) is a life-threatening lung condition that prevents enough oxygen from getting to the lungs and into the blood. People who develop ARDS often are very ill with another disease or have major injuries. The condition leads to a buildup of fluid in the air sacs which prevents enough oxygen from passing into the bloodstream. Symptoms may include difficulty breathing, low blood pressure and organ failure, rapid breathing and shortness of breath.

MalaCards based summary : Adult Respiratory Distress Syndrome, also known as respiratory distress syndrome, adult, is related to pulmonary edema and toxic shock syndrome, and has symptoms including dyspnea, respiratory distress and apnea. An important gene associated with Adult Respiratory Distress Syndrome is CXCL8 (C-X-C Motif Chemokine Ligand 8), and among its related pathways/superpathways are ERK Signaling and PEDF Induced Signaling. The drugs Methylprednisolone and Methylprednisolone hemisuccinate have been mentioned in the context of this disorder. Affiliated tissues include Lung, and related phenotypes are hematopoietic system and homeostasis/metabolism

Disease Ontology : 12 A respiratory failure that results from diffuse injury to the endothelium of the lung (as in sepsis, chest trauma, massive blood transfusion, aspiration of the gastric contents, or pneumonia) and is characterized by pulmonary edema with an abnormally high amount of protein in the edematous fluid and by difficult rapid breathing and hypoxemia.

PubMed Health : 62 About ards: ARDS, or acute respiratory distress syndrome, is a lung condition that leads to low oxygen levels in the blood. ARDS can be life threatening because your body's organs need oxygen-rich blood to work well. People who develop ARDS often are very ill with another disease or have major injuries. They might already be in the hospital when they develop ARDS.

Wikipedia : 74 Acute respiratory distress syndrome (ARDS) is a type of respiratory failure characterized by rapid onset... more...

Related Diseases for Adult Respiratory Distress Syndrome

Diseases in the Adult Respiratory Distress Syndrome family:

Adult Acute Respiratory Distress Syndrome

Diseases related to Adult Respiratory Distress Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 1111)
# Related Disease Score Top Affiliating Genes
1 pulmonary edema 31.4 TNF IL10 F2 CXCL8 CSF3 ACE
2 toxic shock syndrome 31.3 TNF IL6 IL1R1 IL10 CXCL8 CD14
3 aspiration pneumonia 31.2 IL6 F2 ACE
4 chickenpox 31.1 TNF IL6 IL10
5 cerebral aneurysms 31.1 ELN ELANE
6 pleurisy 31.0 TNF CXCL8 ALOX5
7 acute pancreatitis 31.0 TNF PLA2G6 IL6 IL10 ELANE CXCL8
8 cytomegalovirus infection 31.0 TNF IL6 CXCL8
9 interstitial emphysema 31.0 SFTPC SFTPB
10 congestive heart failure 31.0 TNF IL6 ANGPT2 ACE
11 bronchopneumonia 31.0 TNF IL6 IL10 ELANE CXCL8
12 cardiomyopathy, familial hypertrophic, 20 30.9 IL6 ELN CXCL8
13 compartment syndrome 30.9 TNF IL6 F2
14 pulmonary fibrosis 30.9 SFTPD SFTPC SERPINE1 ELN ELANE CXCL8
15 status asthmaticus 30.9 IL1R1 IL10 ELANE CXCL8
16 leptospirosis 30.9 TNF IL6 IL10 F2 CXCL8
17 typhoid fever 30.9 TNF IL6 IL1R1 F2
18 hemophagocytic lymphohistiocytosis 30.8 TNF IL10 CXCL8
19 conjunctivitis 30.8 TNF IL6 IL10 CXCL8
20 leishmaniasis 30.8 TNF IL6 IL10 CXCL8
21 fasciitis 30.8 TNF IL6 CXCL8
22 paracoccidioidomycosis 30.8 TNF IL6 IL10
23 capillary leak syndrome 30.8 IL6 ELANE CXCL8 CSF3
24 vasculitis 30.7 TNF THBD IL6 ELANE
25 common cold 30.7 TNF IL6 IL1R1 IL10 CXCL8
26 severe acute respiratory syndrome 30.7 TNF IL6 IL10 CXCL8
27 bronchopulmonary dysplasia 30.7 SFTPB ELANE CXCL8
28 leprosy 3 30.7 TNF IL6 IL10 CXCL8
29 myeloma, multiple 30.7 TNF IL6 IL10 CXCL8 CSF3
30 engraftment syndrome 30.7 CXCL8 CSF3
31 disseminated intravascular coagulation 30.7 TNF THBD SERPINE1 IL6 IL10 F2
32 idiopathic interstitial pneumonia 30.7 SFTPD SFTPC SFTPB SERPINE1 ELANE CXCL8
33 aortic aneurysm, familial abdominal, 1 30.7 IL6 ELN ELANE ACE
34 myocarditis 30.7 TNF IL6 IL10 ACE
35 visceral leishmaniasis 30.7 TNF IL10 CXCL8
36 tuberculous meningitis 30.7 TNF CXCL8 ALOX5
37 mycobacterium kansasii 30.7 CXCL8 CD14
38 intracranial hypertension 30.7 TNF SERPINE1 F2
39 thrombophilia due to thrombin defect 30.7 THBD SERPINE1 F2
40 arthus reaction 30.6 TNF ELANE ALOX5
41 haemophilus influenzae 30.6 TNF CXCL8
42 bacteriuria 30.6 IL6 CXCL8 CXCL1
43 spinal cord injury 30.6 TNF IL6 CXCL8
44 pharyngitis 30.6 TNF IL6 CXCL8
45 viral pneumonia 30.6 TNF SFTPD IL6 IL10 CXCL8
46 optic nerve disease 30.6 TNF IL6 ELN ACE
47 pyelonephritis 30.6 TNF IL6 IL10 CXCL8 CSF3 ACE
48 periventricular leukomalacia 30.6 TNF IL6 IL1R1
49 scorpion envenomation 30.6 TNF IL6
50 invasive aspergillosis 30.6 SFTPD IL10 CXCL8 CSF3

Graphical network of the top 20 diseases related to Adult Respiratory Distress Syndrome:



Diseases related to Adult Respiratory Distress Syndrome

Symptoms & Phenotypes for Adult Respiratory Distress Syndrome

UMLS symptoms related to Adult Respiratory Distress Syndrome:


dyspnea, respiratory distress, apnea, hemoptysis, cheyne-stokes respiration, coughing, hoarseness, labored breathing

MGI Mouse Phenotypes related to Adult Respiratory Distress Syndrome:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.25 ACE ALOX5 CD14 CSF3 ELANE F2
2 homeostasis/metabolism MP:0005376 10.24 ACE ALOX5 ANGPT2 CD14 ELANE F2
3 immune system MP:0005387 10.22 ACE ALOX5 ANGPT2 CD14 CSF3 ELANE
4 growth/size/body region MP:0005378 10.21 ACE CD14 F2 IL10 IL1R1 IL6
5 cardiovascular system MP:0005385 10.2 ACE ALOX5 ANGPT2 F2 IL10 IL1R1
6 mortality/aging MP:0010768 10.03 ACE ANGPT2 CD14 ELANE F2 IL10
7 adipose tissue MP:0005375 10.02 ACE ALOX5 CD14 IL1R1 IL6 SERPINE1
8 integument MP:0010771 9.91 ANGPT2 CSF3 F2 IL10 IL1R1 IL6
9 neoplasm MP:0002006 9.56 ACE ELANE IL10 IL1R1 IL6 SERPINE1
10 respiratory system MP:0005388 9.4 ANGPT2 CD14 F2 IL10 IL1R1 IL6

Drugs & Therapeutics for Adult Respiratory Distress Syndrome

PubMed Health treatment related to Adult Respiratory Distress Syndrome: 62

ARDS is treated in a hospital's intensive care unit. Current treatment approaches focus on improving blood oxygen levels and providing supportive care. Doctors also will try to pinpoint and treat the underlying cause of the condition.

Drugs for Adult Respiratory Distress Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 414)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Methylprednisolone Approved, Vet_approved Phase 4 83-43-2 6741
2
Methylprednisolone hemisuccinate Approved Phase 4 2921-57-5
3
Prednisolone Approved, Vet_approved Phase 4 50-24-8 5755
4 Prednisolone acetate Approved, Vet_approved Phase 4 52-21-1
5
Prednisolone phosphate Approved, Vet_approved Phase 4 302-25-0
6
Tramadol Approved, Investigational Phase 4 27203-92-5 33741
7
Sufentanil Approved, Investigational Phase 4 56030-54-7 41693
8
Clonidine Approved Phase 4 4205-90-7 2803
9
Nefopam Approved, Investigational Phase 4 13669-70-0
10
Atracurium Approved, Experimental, Investigational Phase 4 64228-79-1 47319
11
Cisatracurium Approved Phase 4 96946-41-7
12
Carbon monoxide Approved, Investigational Phase 4 630-08-0 281
13
Morphine Approved, Investigational Phase 4 57-27-2 5288826
14
Heparin Approved, Investigational Phase 4 9005-49-6 772 46507594
15
Acetylcysteine Approved, Investigational Phase 4 616-91-1 12035
16
Desflurane Approved Phase 4 57041-67-5 42113
17
Ketamine Approved, Vet_approved Phase 4 6740-88-1 3821
18
Propofol Approved, Investigational, Vet_approved Phase 4 2078-54-8 4943
19
Rocuronium Approved Phase 4 119302-91-9, 143558-00-3 441290
20
Zinc Approved, Investigational Phase 4 7440-66-6 32051
21
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4 437-38-7 3345
22
Metformin Approved Phase 4 657-24-9 4091 14219
23
Lidocaine Approved, Vet_approved Phase 4 137-58-6 3676
24
Midazolam Approved, Illicit Phase 4 59467-70-8 4192
25
Dexmedetomidine Approved, Vet_approved Phase 4 113775-47-6 5311068 68602
26
Remifentanil Approved Phase 4 132875-61-7 60815
27
Budesonide Approved Phase 4 51333-22-3 63006 5281004
28 Poractant alfa Approved Phase 4 129069-19-8
29 Beractant Approved Phase 4 108778-82-1
30
Betamethasone Approved, Vet_approved Phase 4 378-44-9 9782
31
Cysteine Approved, Nutraceutical Phase 4 52-90-4 5862
32
Glycine Approved, Nutraceutical, Vet_approved Phase 4 56-40-6 750
33
Prednisolone hemisuccinate Experimental Phase 4 2920-86-7
34 Sivelestat Investigational Phase 4 127373-66-4
35 Antiemetics Phase 4
36 Gastrointestinal Agents Phase 4
37 Methylprednisolone Acetate Phase 4
38 Protective Agents Phase 4
39 Neuroprotective Agents Phase 4
40 Antineoplastic Agents, Hormonal Phase 4
41 Fibrin Fibrinogen Degradation Products Phase 4
42 Hydrocortisone-17-butyrate Phase 4
43 Antibiotics, Antitubercular Phase 4
44 Anti-Bacterial Agents Phase 4
45 Ophthalmic Solutions Phase 4
46 Plasma-lyte 148 Phase 4
47 Adrenergic beta-Agonists Phase 4
48 Serine Proteinase Inhibitors Phase 4
49 Anticoagulants Phase 4
50 Fibrinolytic Agents Phase 4

Interventional clinical trials:

(show top 50) (show all 1276)
# Name Status NCT ID Phase Drugs
1 Effect of Treatment With Stress-Doses Glucocorticoid on Mortality in Patients With ARDS and Relative Adrenal Insufficiency Unknown status NCT00773058 Phase 4 hydrocortisone;placebo
2 Effects of NMBA on the Alteration of Transpulmonary Pressures at the Early Phase of ARDS Unknown status NCT01573715 Phase 4 NIMBEX;NIMBEX
3 Impact of Fluid Resuscitation Therapy on Pulmonary Edema as Measured by Alveolar Fluid Clearance in Patients With Acute Respiratory Distress Syndrome (ARDS) Unknown status NCT01763853 Phase 4 4% albumin
4 the Study of Using Esophageal Pressure to Guide the PEEP Setting in Abdominal Hypertension Patients Who Undergoing Mechanical Ventilation Unknown status NCT01825304 Phase 4
5 Assessment of the Cerebral Tissue Oxygenation and the Bioelectrical Brain Activity of Preterm Newborns During Administration of Two Different Surfactant Unknown status NCT01941524 Phase 4 Poractant alfa instillation;Beractant instillation
6 Functional Residual Capacity Guided Alveolar Recruitment Strategy in Patients With Acute Respiratory Failure After Cardiac Surgery Unknown status NCT01280019 Phase 4
7 Propofol and Remifentanil Versus Midazolam and Remifentanil as Premedication Allowing Very Early Extubation After Surfactant Treatment in Preterm Neonates With Respiratory Distress Syndrome Unknown status NCT00797160 Phase 4 propofol
8 Comparative Trial of Two Strategies of RDS Treatment in Newborns With Birth Weight > 1500 Grams Unknown status NCT00277030 Phase 4 Surfactant
9 Early Bubble CPAP (EBCPAP) in Very Low Birth Weight Infants (VLBWI) Unknown status NCT00368680 Phase 4
10 Efficacy Evaluation of Surfactant Administration for Respiratory Distress Syndrome Treatment Via Laryngeal Mask Airway. A Randomized Controlled Trial Unknown status NCT01173237 Phase 4
11 The Effect of 6-Methyl-Prednisolone on Organ Dysfunction and Mortality of Patients With Unresolving Multiple Organ Dysfunction Syndrome Unknown status NCT00127985 Phase 4 6-methyl-prednisolone
12 Prevention of Chronic Lung Disease (CLD) in Preterm Infants -A New Therapeutic Regimen Unknown status NCT00883532 Phase 4 budesonide;surfactant and air (placebo)
13 THE EFFECT OF SUSTAINED LUNG INFLATION MANEUVER APPLIED THROUGH NASAL PRONG ON EARLY AND LATE RESPIRATORY MORBIDITIES IN PRETERM INFANTS Unknown status NCT02887924 Phase 4
14 A Multicentre, Randomized, Clinical Trial of Noninvasive Ventilation: Neurally Adjusted Ventilatory Assist (NAVA) vs. Pressure Support in Pediatric Acute Respiratory Failure - NINAVAPed Protocol Unknown status NCT01873521 Phase 4
15 A MULTICENTER, RANDOMIZED, CONTROLLED STUDY OF EPIDURAL ANALGESIA FOR SEVERE ACUTE PANCREATITIS Unknown status NCT02126332 Phase 4
16 The Effects of High Doze Tranexamic Acid Application on Hemorrhage, Blood Transfusion, Fibrin Degradation Products, and Kidney Functions for Total Hip Arthroplasty Unknown status NCT02094066 Phase 4 tranexamic acid;serum physiologic
17 The Effect of Withholding Feeds During Red Blood Cell Transfusion on Development of TRAGI in Very Low Birth Weight Infants Unknown status NCT02132819 Phase 4
18 Impact of Various Sedation Regimens on the Incidence of Post-sedation Delirium in Patients Receiving Mechanical Ventilation Unknown status NCT02117726 Phase 4 Dexmedetomidine,midazolam;Propofol,midazolam
19 Evaluation of High-dose Corticosteroids on Microcirculation Alterations in Cardiac Surgery, by FMD (Flow Mediated vasoDilation), Near Infrared Spectrophotometry (NIRS) and Biological Analysis (Syndecan-1) Unknown status NCT02798068 Phase 4 Solu-medrol or placebo administration
20 Effect of Early 48-hour Sevoflurane Inhalation on Gas Exchange and Inflammation in Patients Presenting With Acute Respiratory Distress Syndrome (ARDS) : a Monocentric, Prospective, Randomized Study. Completed NCT02166853 Phase 4 sevoflurane;midazolam
21 Corticosteroid Mediates Acute Respiratory Distress Syndrome Via NLRP3 Inflammasome Signaling Pathway Completed NCT02819453 Phase 4 Methylprednisolone
22 A Comparative, Randomised Controlled Trial for Evaluating the Efficacy of Dexamethasone in the Treatment of Patients With Acute Respiratory Distress Syndrome Completed NCT01731795 Phase 4 Dexamethasone
23 Effects Of A Recruitment Maneuver On Plasma Levels of sRAGE, The Soluble Form of The Receptor For Advanced Glycation End Products, In Patients With Diffuse Acute Respiratory Distress Syndrome (ARDS) Completed NCT01600651 Phase 4
24 The Study of Pharmacokinetics and Pharmacodynamics of a Loading Dose Cisatracurium in Critically Ill Patients Completed NCT03337373 Phase 4 cisatracurium
25 Efficacy and Safety of Sivelestat Sodium Hydrate in Acute Lung Injury Associated With Systemic Inflammatory Response Syndrome, Compared With the Conventional Treatment in Japan Completed NCT00219375 Phase 4 Sivelestat sodium hydrate;Sivelestat sodium hydrate
26 Comparison of Effectiveness of Nasal CPAP and Nasal IMV in Early Rescue Surfactant Treatment in Preterm Infants Completed NCT01741129 Phase 4
27 Effect of Perioperative Lung Protective Strategies on the Occurrence of Postoperative Pulmonary Complications in Patients Undergoing Lumbar Spinal Surgery in the Prone Position Completed NCT02373475 Phase 4
28 Effect of Steroids Given Over 24 Hours on Cytokine Release and Urinary Desmosine Levels in Patients Undergoing Bilateral Total Knee Replacement Completed NCT01399268 Phase 4 Hydrocortisone;Saline
29 Influence of N-Acetylcysteine on Morbidity, Oxygenation and Cytokine Levels in Partial or Total Esophagectomy for Cancer. A Multicenter, Prospective, Randomised Double Blind, Placebo-controlled Study Completed NCT00512265 Phase 4 n-acetylcysteine;250mL glucose 5%
30 Restrictive vs. Liberal Oxygen Therapy for Trauma Patients. PILOT: The TRAUMOX Trial Completed NCT03491644 Phase 4 Titrated Oxygen;Liberal Oxygen
31 An International, Open, Randomized, Controlled Study to Evaluate the Efficacy of Combining Prophylactic Curosurf® With Early Nasal CPAP Versus Early Nasal CPAP Alone in Very Preterm Infants at Risk of Respiratory Distress Syndrome Completed NCT00501982 Phase 4 Poractant alfa (Curosurf®)
32 Comparative Study of the Use of Remifentanil Versus Morphine for Sedation and Analgesia of Premature Neonates During Mechanical Ventilation in the Treatment of Respiratory Distress Syndrome (RDS) Completed NCT00391105 Phase 4 Remifentanil
33 Synchronized Intermittent Mandatory Ventilation (SIMV) Versus Nasal Intermittent Positive Pressure Ventilation (NIPPV) In Preterm Infants With Respiratory Distress Completed NCT00486850 Phase 4
34 Premedication for Non-Emergency Endotracheal Intubation In the NICU Completed NCT01749501 Phase 4 Rocuronium
35 Effects of Bolus Surfactant Therapy on Serial Peripheral Perfusion Index and Tissue Carbon Monoxide Measurements in Preterm Infants With Severe Respiratory Distress Syndrome Completed NCT01923844 Phase 4 exogenous surfactant
36 Supportive Measures in Treatment of Aluminum Phosphide Poisoning as a Trial to Reduce Mortality at Assiut University Hospital Completed NCT03879356 Phase 4 N-acetyl cysteine
37 Rescue Surfactant for Respiratory Distress Syndrome (RDS) in Newborns: Comparing Efficacy of Delivery Via Laryngeal Mask Airway to Delivery by Endotracheal Intubation Completed NCT01042600 Phase 4
38 STUDY OF PULMONARY AND SYSTEMIC INFLAMMATORY RESPONSE SECONDARY TO LUNG RESECTION SURGERY USING INTRAVENOUS ANESTHESIA VERSUS INHALATION ANESTHESIA WITH HALOGENATED AGENTS Completed NCT02168751 Phase 4 propofol;Sevoflurane
39 ON Pump vs OFF Pump Myocardial Revascularization in High Risk Patients: a Randomized Study Completed NCT01290952 Phase 4
40 Evaluating Fluid Strategies in Thoracic Surgery Patients Utilizing a Goal Directed Approach Completed NCT02135146 Phase 4 Plasmalyte 3ml/kg/hr group;Plasmalyte 6ml/kg/hr group
41 Investigating Nutritional Therapy With EPA, GLA and Antioxidants Role in Sepsis Treatment-INTERSEPT STUDY Completed NCT00329680 Phase 4
42 Systematic Early Use of Neuromuscular Blocking Agents in ARDS Patients Completed NCT00299650 Phase 4 cisatracurium;Placebo;Cisatracurium besilate
43 Recruitment Maneuver Increases Oxygenation After Intubation in Hypoxemic ICU Patients: a Randomized Controlled Study Completed NCT01014299 Phase 4
44 Laryngoscope Versus CMAC for Endotracheal Intubation in Patients Undergoing Emergent Airway Management Completed NCT01710891 Phase 4
45 Effect Of Ketamine Infusion On Oxygenation And Ventilation Mechanics In Patients With Chronic Obstructive Pulmonary Disease Applied One Lung Ventilation Completed NCT02962999 Phase 4 Ketamine;Saline
46 Prospective Validation of a Plasma Transfusion Dosing Algorithm in Patients With Chronic Liver Disease Completed NCT02366845 Phase 4
47 Efficacy of Nebulized Heparin and Salbutamol in Mechanically Ventilated Patients With Acute Exacerbation Chronic Obstructive Pulmonary Disease: a Randomized Clinical Trial Completed NCT03333395 Phase 4 Nebulized heparin and salbutamol;Nebulized salbutamol
48 Perioperative Fluid Treatment in Colorectal Surgery Completed NCT03537989 Phase 4 Saline
49 Effect of Inhalation Sedation With Sevoflurane Compared With Propofol on the Sepsis-related Acute Respiratory Distress Syndrome (ARDS) Course. Recruiting NCT04014218 Phase 4 Inhalation Sedation;Intravenous Sedation
50 Life-threatening Acute Respiratory Failure in Children: to Breathe or Not to Breathe Spontaneously, That's the Question Recruiting NCT02902055 Phase 4 Neuromuscular Blocking Agents;Isotonic saline

Search NIH Clinical Center for Adult Respiratory Distress Syndrome

Inferred drug relations via UMLS 71 / NDF-RT 50 :


Acetylcysteine
Albumin Human, USP
ALBUMIN,HUMAN INJ
Epoprostenol
Epoprostenol Sodium
Methylprednisolone
methylprednisolone acetate
Methylprednisolone Sodium Succinate
Nitrous Oxide

Cochrane evidence based reviews: respiratory distress syndrome, adult

Genetic Tests for Adult Respiratory Distress Syndrome

Anatomical Context for Adult Respiratory Distress Syndrome

MalaCards organs/tissues related to Adult Respiratory Distress Syndrome:

40
Lung, Neutrophil, Liver, Endothelial, Heart, Brain, Bone
LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database

Cells/anatomical compartments in embryo or adult related to Adult Respiratory Distress Syndrome:
# Tissue Anatomical CompartmentCell Relevance
1 Lung Pulmonary Capillary Plexus Affected by disease
2 Lung Alveoli Alveolar Epithelial Type 1 Cells Affected by disease, potential therapeutic candidate
3 Lung Alveoli Alveolar Epithelial Type 2 Cells Affected by disease, potential therapeutic candidate

Publications for Adult Respiratory Distress Syndrome

Articles related to Adult Respiratory Distress Syndrome:

(show top 50) (show all 4331)
# Title Authors PMID Year
1
Association of IL-8-251A/T polymorphism with incidence of Acute Respiratory Distress Syndrome (ARDS) and IL-8 synthesis after multiple trauma. 61 54
17498967 2007
2
Copper stimulates the synthesis and release of interleukin-8 in human endothelial cells: a possible early role in systemic inflammatory responses. 61 54
12865660 2003
3
Anti-inflammatory activity of neutrophil elastase inhibitors. 54 61
12833649 2003
4
Phospholipase A2 is present in meconium and inhibits the activity of pulmonary surfactant: an in vitro study. 54 61
11332933 2001
5
Anti-interleukin-8 autoantibody in the tracheobronchial aspirate of infants with chronic lung disease. 54 61
11207999 2001
6
Levels of IL-8 and myeloperoxidase in the lungs of pneumonia patients. 61 54
11269653 2001
7
Inhaled porcine pancreatic elastase causes bronchoconstriction via a bradykinin-mediated mechanism. 54 61
11007574 2000
8
Interleukin-8 expression by fetal and neonatal pulmonary cells in hyaline membrane disease and amniotic infection. 54 61
10960493 2000
9
CXCR2 stimulation primes CXCR1 [Ca2+]i responses to IL-8 in human neutrophils. 61 54
10588510 1999
10
Pulmonary surfactant in health and human lung diseases: state of the art. 54 61
10445627 1999
11
Upregulated tumor necrosis factor-alpha gene expression in the hypoplastic lung in patients with congenital diaphragmatic hernia. 61 54
9880689 1998
12
Stimulation of inflammatory markers after blunt trauma. 54 61
9692580 1998
13
Cytokine release and mitogenic activity in the viridans streptococcal shock syndrome. 54 61
9619375 1998
14
Effect of PDE4 inhibitors on zymosan-induced IL-8 release from human neutrophils: synergism with prostanoids and salbutamol. 54 61
9559913 1998
15
Biochemical and pharmacological characterization of FR134043, a novel elastase inhibitor. 54 61
9592030 1998
16
Lipopolysaccharide-induced NF-kappaB activation and cytokine release in human alveolar macrophages is PKC-independent and TK- and PC-PLC-dependent. 61 54
9490656 1998
17
Biochemical and pharmacological characterization of FK706, a novel elastase inhibitor. 54 61
9389382 1997
18
Relative production of tumour necrosis factor alpha and interleukin 10 in adult respiratory distress syndrome. 61 54
9176536 1997
19
Protein kinase inhibitor attenuates an increase in endothelial monolayer permeability induced by tumour necrosis factor-alpha. 61 54
9424406 1997
20
Studies on the interaction of IL-8 with human plasma alpha 2-macroglobulin: evidence for the presence of IL-8 complexed to alpha 2-macroglobulin in lung fluids of patients with adult respiratory distress syndrome. 54 61
9029135 1997
21
The regional production of cytokines and lactate in sepsis-related multiple organ failure. 54 61
9001289 1997
22
Secretory leukoprotease inhibitor: partnering alpha 1-proteinase inhibitor to combat pulmonary inflammation. 54 61
8994529 1996
23
Interleukin-8 and adult respiratory distress syndrome. 61 54
8968789 1996
24
Sustained high levels of circulatory interleukin-8 are associated with a poor outcome in patients with adult respiratory distress syndrome. 61 54
8968796 1996
25
Tumor necrosis factor alpha (TNF alpha)-induced ICAM-1 surface expression in airway epithelial cells in vitro: possible signal transduction mechanisms. 54 61
8906209 1996
26
Anti-IL-8 autoantibodies in alveolar fluid from patients with the adult respiratory distress syndrome. 61 54
8805676 1996
27
The association between mortality rates and decreased concentrations of interleukin-10 and interleukin-1 receptor antagonist in the lung fluids of patients with the adult respiratory distress syndrome. 54 61
8686976 1996
28
Detection of IL-5 and IL-1 receptor antagonist in bronchoalveolar lavage fluid in acute eosinophilic pneumonia. 61 54
8648034 1996
29
[High concentrations of interleukin-8 in bronchoalveolar lavage fluid from a patient with adult respiratory distress syndrome]. 61 54
8753113 1996
30
The role of cytokines in human lung fibrosis. 54 61
8680382 1996
31
Cytokines in human lung fibrosis. 61 54
8678788 1996
32
Elastin fibers and the diagnosis of bacterial pneumonia in the adult respiratory distress syndrome. 54 61
7587258 1995
33
GRO alpha and interleukin-8 in Pneumocystis carinii or bacterial pneumonia and adult respiratory distress syndrome. 61 54
7582292 1995
34
Influence of heparin thromboprophylaxis on plasma leucocyte elastase levels following lobectomy for lung carcinoma. 61 54
7578893 1995
35
Interleukin-8 increases endothelial permeability independent of neutrophils. 61 54
7636916 1995
36
Relationship between alpha-tocopherol and polymorphonuclear leukocyte elastase in septic adult respiratory distress syndrome. 61 54
7582866 1995
37
Bronchoalveolar lavage fluid phospholipase A2 activities are increased in human adult respiratory distress syndrome. 54 61
7631805 1995
38
The value of polymorphonuclear elastase in adult respiratory distress syndrome. 61 54
7554278 1995
39
Immunosuppressive properties of surfactant and plasma on alveolar macrophages. 54 61
7897303 1995
40
Plasma interleukin 8 and polymorphonuclear leukocyte elastase concentrations in patients with septic shock. 61 54
7583359 1995
41
Use of elastin fibre detection in the diagnosis of ventilator associated pneumonia. 54 61
7886642 1995
42
The role of neutrophil elastase in chronic inflammation. 54 61
7952645 1994
43
Prophylactic treatment in the adult respiratory distress syndrome. 54 61
7613495 1994
44
Leukotrienes and alpha tumor necrosis factor levels in the bronchoalveolar lavage fluid of patient at risk for the adult respiratory distress syndrome. 61 54
7808646 1994
45
Tumor necrosis factor-alpha-induced inhibition of phosphatidylcholine synthesis by human type II pneumocytes is partially mediated by prostaglandins. 61 54
8040266 1994
46
Effect of pentoxifylline and somatostatin on tumour necrosis factor production by human pulmonary macrophages. 54 61
7834820 1994
47
[Soluble thrombomodulin: as a marker of endothelial injury]. 54 61
8051797 1994
48
Significance of alpha-tocopherol and interleukin 8 in septic adult respiratory distress syndrome. 61 54
8091005 1994
49
Effect of pentoxifylline on the inhibition of surfactant synthesis induced by TNF-alpha in human type II pneumocytes. 61 54
8118639 1994
50
High levels of interleukin-8 in the blood and alveolar spaces of patients with pneumonia and adult respiratory distress syndrome. 61 54
8406851 1993

Variations for Adult Respiratory Distress Syndrome

Expression for Adult Respiratory Distress Syndrome

Search GEO for disease gene expression data for Adult Respiratory Distress Syndrome.

Pathways for Adult Respiratory Distress Syndrome

Pathways related to Adult Respiratory Distress Syndrome according to GeneCards Suite gene sharing:

(show top 50) (show all 54)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.84 TNF IL6 IL1R1 IL10 ELN CXCL8
2
Show member pathways
13.66 TNF PLA2G6 IL6 IL1R1 IL10 F2
3
Show member pathways
13.44 TNF IL6 IL1R1 IL10 CXCL8 CXCL1
4
Show member pathways
13.39 TNF IL6 IL1R1 IL10 CXCL8 CXCL1
5
Show member pathways
13.32 TNF PLA2G6 IL6 IL1R1 IL10 CXCL8
6
Show member pathways
13.14 TNF SFTPD SERPINE1 IL6 IL10 CXCL8
7
Show member pathways
12.96 TNF IL6 IL1R1 CXCL8 CXCL1 ANGPT2
8
Show member pathways
12.59 TNF IL6 IL10 F2 CXCL1 CD14
9 12.39 TNF IL1R1 CXCL8 CD14
10
Show member pathways
12.38 TNF IL6 CXCL8 CXCL1 CSF3
11
Show member pathways
12.37 TNF IL6 IL10 CXCL8 CXCL1
12
Show member pathways
12.37 TNF SERPINE1 IL6 F2 ALOX5
13
Show member pathways
12.36 TNF IL6 IL1R1 CXCL8 CD14
14 12.33 TNF IL6 IL1R1 F2 CXCL8
15
Show member pathways
12.29 TNF IL6 CXCL8 CD14
16 12.28 IL6 ELANE CXCL8 CD14
17 12.26 TNF IL6 CXCL8 CXCL1
18 12.26 TNF IL6 IL10 CD14
19
Show member pathways
12.25 TNF SERPINE1 IL6 IL1R1 CXCL8
20 12.2 TNF IL6 IL10 CXCL8
21
Show member pathways
12.13 TNF SFTPD IL6 IL1R1 CXCL8 CD14
22
Show member pathways
12.09 TNF IL6 IL1R1 IL10
23
Show member pathways
12.07 TNF IL6 F2 CD14
24 12.05 TNF IL6 IL10 CXCL8
25 12.05 TNF IL6 IL10 CSF3 CD14
26 12.04 TNF IL6 IL10 CXCL8 ALOX5
27 11.98 SERPINE1 IL6 CXCL8 CXCL1
28 11.97 TNF IL1R1 CXCL8 CXCL1 CD14
29 11.96 TNF THBD SERPINE1 IL6 CXCL8
30 11.94 TNF IL6 IL1R1 CSF3 CD14
31 11.92 TNF IL6 CXCL8 CXCL1
32
Show member pathways
11.89 IL6 CXCL8 CXCL1 CSF3 CD14
33 11.88 TNF PLA2G6 IL6 IL1R1 CXCL8 CXCL1
34 11.83 IL6 CXCL8 CXCL1 CD14
35 11.79 TNF IL1R1 IL10
36 11.77 TNF IL6 IL10 CXCL1
37 11.76 TNF IL6 IL10 CXCL8 CD14
38 11.72 TNF THBD IL6 IL10 CD14
39
Show member pathways
11.68 TNF IL6 CXCL8
40 11.61 TNF IL1R1 CD14
41 11.56 TNF IL6 CXCL8 CXCL1 CD14
42 11.55 TNF IL6 ELANE
43 11.51 TNF IL6 IL1R1 IL10 CXCL8 CXCL1
44
Show member pathways
11.49 SFTPD SFTPC SFTPB
45 11.47 TNF IL6 IL10 CXCL8 CSF3
46 11.43 TNF IL6 IL10
47 11.43 TNF SFTPC IL6 ELN CXCL8 CSF3
48 11.42 TNF IL6 IL10 CD14
49 11.38 THBD IL6 CXCL8
50
Show member pathways
11.23 SFTPD SFTPC SFTPB

GO Terms for Adult Respiratory Distress Syndrome

Cellular components related to Adult Respiratory Distress Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.91 TNF SFTPD SFTPC SFTPB SERPINE1 IL6
2 external side of plasma membrane GO:0009897 9.65 TNF IL1R1 F2 CD14 ACE
3 extracellular space GO:0005615 9.58 TNF THBD SFTPD SFTPC SFTPB SERPINE1
4 lamellar body GO:0042599 9.37 SFTPC SFTPB
5 clathrin-coated endocytic vesicle GO:0045334 9.33 SFTPD SFTPC SFTPB
6 multivesicular body lumen GO:0097486 9.32 SFTPC SFTPB

Biological processes related to Adult Respiratory Distress Syndrome according to GeneCards Suite gene sharing:

(show all 27)
# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.95 TNF IL6 IL1R1 IL10 CXCL8 CXCL1
2 response to lipopolysaccharide GO:0032496 9.88 THBD IL10 ELANE CD14
3 cellular protein metabolic process GO:0044267 9.88 SFTPD SFTPC SFTPB IL6 F2
4 leukocyte migration GO:0050900 9.85 TNF THBD F2 ELANE ANGPT2
5 positive regulation of DNA-binding transcription factor activity GO:0051091 9.83 TNF IL6 IL10 CSF3
6 antimicrobial humoral immune response mediated by antimicrobial peptide GO:0061844 9.79 F2 CXCL8 CXCL1
7 response to glucocorticoid GO:0051384 9.79 TNF IL6 IL10
8 positive regulation of smooth muscle cell proliferation GO:0048661 9.77 TNF IL6 ELANE
9 inflammatory response GO:0006954 9.76 TNF IL6 IL1R1 IL10 CXCL8 CXCL1
10 positive regulation of interferon-gamma production GO:0032729 9.74 TNF IL1R1 CD14
11 positive regulation of cytokine secretion GO:0050715 9.69 TNF IL10 CD14
12 leukocyte chemotaxis GO:0030595 9.67 IL10 CXCL8 CXCL1
13 positive regulation of ceramide biosynthetic process GO:2000304 9.63 TNF PLA2G6
14 negative regulation of lipid storage GO:0010888 9.63 TNF IL6
15 negative regulation of platelet activation GO:0010544 9.62 THBD F2
16 respiratory gaseous exchange GO:0007585 9.62 SFTPD SFTPC SFTPB ELN
17 endothelial cell apoptotic process GO:0072577 9.61 TNF IL10
18 response to molecule of bacterial origin GO:0002237 9.61 IL10 CXCL8 CD14
19 neutrophil mediated immunity GO:0002446 9.6 IL6 ACE
20 negative regulation of cytokine secretion involved in immune response GO:0002740 9.58 TNF IL10
21 neutrophil mediated killing of gram-negative bacterium GO:0070945 9.56 F2 ELANE
22 positive regulation of JAK-STAT cascade GO:0046427 9.56 TNF IL6 IL10 F2
23 cytokine-mediated signaling pathway GO:0019221 9.56 TNF IL6 IL1R1 IL10 CXCL8 CXCL1
24 negative regulation of chemokine biosynthetic process GO:0045079 9.55 IL6 ELANE
25 receptor biosynthetic process GO:0032800 9.54 TNF IL10
26 negative regulation of fibrinolysis GO:0051918 9.54 THBD SERPINE1 F2
27 cellular response to lipopolysaccharide GO:0071222 9.23 TNF SERPINE1 IL6 IL10 CXCL8 CXCL1

Molecular functions related to Adult Respiratory Distress Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protease binding GO:0002020 9.46 TNF SERPINE1 IL1R1 ELANE
2 lipopolysaccharide binding GO:0001530 9.43 SFTPD F2 CD14
3 growth factor activity GO:0008083 9.35 IL6 IL10 F2 CXCL1 CSF3
4 cytokine activity GO:0005125 9.1 TNF IL6 IL10 CXCL8 CXCL1 CSF3

Sources for Adult Respiratory Distress Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
Content
Loading form....