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ALI
MCID: ADL010
MIFTS: 71

Adult Respiratory Distress Syndrome (ALI)

Categories: Blood diseases, Cardiovascular diseases, Rare diseases, Respiratory diseases
Genes Variations Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
Sources

Aliases & Classifications for Adult Respiratory Distress Syndrome

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MalaCards integrated aliases for Adult Respiratory Distress Syndrome:

Name: Adult Respiratory Distress Syndrome 12 20 15 32
Acute Respiratory Distress Syndrome 12 74 20 15 17
Respiratory Distress Syndrome, Adult 74 20 71
Non-Cardiogenic Pulmonary Edema 12 20 71
Acute Lung Injury 20 58 17
Ards 12 20 62
Respiratory Distress Syndrome 44 62
Shock Lung 12 20
Increased-Permeability Pulmonary Edema 20
Respiratory Distress Syndrome Adult 54
Acute Respiratory Distress 54
Stiff Lung 20
Adult Rds 12
Ali 20

Characteristics:

Orphanet epidemiological data:

58
acute lung injury
Prevalence: 1-5/10000 (Europe);

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Respiratory diseases Cardiovascular diseases Blood diseases
See all MalaCards categories (disease lists)
ICD10: 32
Orphanet: 58  
Rare respiratory diseases


External Ids:

Disease Ontology 12 DOID:11394
MeSH 44 D012128
NCIt 50 C3353
SNOMED-CT 67 155627006
ICD10 32 J80
MESH via Orphanet 45 D055371
UMLS via Orphanet 72 C0242488
Orphanet 58 ORPHA178320
UMLS 71 C0035222 C3241936
Sources

Summaries for Adult Respiratory Distress Syndrome

About this section
GARD : 20 Acute respiratory distress syndrome (ARDS) is a life-threatening lung condition that prevents enough oxygen from getting to the lungs and into the blood. People who develop ARDS often are very ill with another disease or have major injuries. The condition leads to a buildup of fluid in the air sacs which prevents enough oxygen from passing into the bloodstream. Symptoms may include difficulty breathing, low blood pressure and organ failure, rapid breathing and shortness of breath.

MalaCards based summary : Adult Respiratory Distress Syndrome, also known as acute respiratory distress syndrome, is related to respiratory distress syndrome, infant and surfactant metabolism dysfunction, pulmonary, 1, and has symptoms including dyspnea, hemoptysis and apnea. An important gene associated with Adult Respiratory Distress Syndrome is IGHMBP2 (Immunoglobulin Mu DNA Binding Protein 2), and among its related pathways/superpathways are Cytokine Signaling in Immune system and Toll-Like receptor Signaling Pathways. The drugs Propofol and Cisatracurium have been mentioned in the context of this disorder. Affiliated tissues include Lung, and related phenotypes are respiratory failure and tachypnea

Disease Ontology : 12 A respiratory failure that results from diffuse injury to the endothelium of the lung (as in sepsis, chest trauma, massive blood transfusion, aspiration of the gastric contents, or pneumonia) and is characterized by pulmonary edema with an abnormally high amount of protein in the edematous fluid and by difficult rapid breathing and hypoxemia.

PubMed Health : 62 About ards: ARDS, or acute respiratory distress syndrome, is a lung condition that leads to low oxygen levels in the blood. ARDS can be life threatening because your body's organs need oxygen-rich blood to work well. People who develop ARDS often are very ill with another disease or have major injuries. They might already be in the hospital when they develop ARDS.

Wikipedia : 74 Acute respiratory distress syndrome (ARDS) is a type of respiratory failure characterized by rapid onset... more...

Sources

Related Diseases for Adult Respiratory Distress Syndrome

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Diseases in the Adult Respiratory Distress Syndrome family:

Adult Acute Respiratory Distress Syndrome

Diseases related to Adult Respiratory Distress Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 1210)
# Related Disease Score Top Affiliating Genes
1 respiratory distress syndrome, infant 33.2 SFTPC GJB2 ABCA3
2 surfactant metabolism dysfunction, pulmonary, 1 32.9 SFTPC SFTPB ABCA3
3 staphylococcal toxic shock syndrome 32.5 TNF IL1B
4 pulmonary edema 32.0 TNF IL1B FGF7 CXCL8
5 toxic shock syndrome 31.9 TNF IL6 IL1B CXCL8
6 disseminated intravascular coagulation 31.8 TNF THBD IL6 ELANE
7 exudative vitreoretinopathy 1 31.7 TNF IL6 IL1B CXCL8 ANGPT1
8 bronchiolitis 31.5 TNF SFTPD IL6 IL1B CXCL8
9 acute pancreatitis 31.4 TNF MPO IL6 IL1B ELANE CXCL8
10 plasmodium vivax malaria 31.3 TNF THBD IL6 IL1B
11 leptospirosis 31.3 TNF IL6 IL1B CXCL8
12 disease by infectious agent 31.3 TNF SFTPD IL6 IL1B
13 pyelonephritis 31.3 TNF IL6 IL1B CXCL8
14 viral pneumonia 31.2 TNF SFTPD IL6 CXCL8
15 allergic disease 31.2 TNF MPO IL6 IL1B
16 interstitial emphysema 31.2 SFTPD SFTPC SFTPB ABCA3
17 cryptogenic organizing pneumonia 31.2 TNF SFTPD SFTPC MPO CXCL8
18 bacterial pneumonia 31.2 TNF SFTPD SFTPB IL6 IL1B ELN
19 sleep apnea 31.2 TNF IL6 IL1B CXCL8
20 bronchiolitis obliterans 31.2 TNF SFTPD MPO IL6 CXCL8
21 fasciitis 31.2 TNF IL6 CXCL8
22 pancreatitis 31.1 TNF IL6 IL1B ELANE
23 respiratory failure 31.1 TNF THBD SFTPD SFTPC SFTPB MPO
24 preterm premature rupture of the membranes 31.1 TNF IL6 IL1B CXCL8
25 bronchiectasis 31.1 TNF MPO IL6 IL1B ELANE CXCL8
26 peritonitis 31.1 TNF MPO IL6 IL1B ELANE CXCL8
27 common cold 31.1 TNF IL6 IL1B CXCL8
28 exanthem 31.1 TNF IL6 IL1B CXCL8
29 acute interstitial pneumonia 31.1 TNF SFTPD SFTPC SFTPB IL6 ABCA3
30 severe acute respiratory syndrome 31.1 TNF IL6 IL1B CXCL8
31 pleurisy 31.1 TNF MPO CXCL8 ALOX5
32 bronchopneumonia 31.1 TNF MPO IL6 IL1B ELANE CXCL8
33 pulmonary fibrosis 31.1 SFTPD SFTPC MPO IL1B FGF7 ELN
34 bacterial infectious disease 31.1 TNF IL6 IL1B ELANE CXCL8
35 pulmonary disease, chronic obstructive 31.1 TNF SFTPD SFTPB MPO IL6 IL1B
36 respiratory distress syndrome in premature infants 31.1 SFTPC SFTPB ABCA3
37 necrotizing fasciitis 31.1 IL6 IL1B CXCL8
38 cardiomyopathy, familial hypertrophic, 20 31.1 TNF SFTPB IL6 ELN CXCL8
39 liver disease 31.1 TNF IL6 IL1B CXCL8 CP
40 mycoplasma pneumoniae pneumonia 31.1 TNF SFTPD IL6
41 capillary leak syndrome 31.0 IL6 ELANE CXCL8
42 neutropenia 31.0 TNF MPO IL6 IL1B ELANE CXCL8
43 typhoid fever 31.0 TNF THBD IL6 IL1B
44 extrinsic allergic alveolitis 31.0 SFTPD MPO IL6 IL1B ELANE CXCL8
45 human cytomegalovirus infection 31.0 IL6 IL1B CXCL8
46 vasculitis 31.0 TNF THBD MPO IL6 ELANE
47 gastroenteritis 31.0 TNF IL6 IL1B CXCL8
48 bacterial sepsis 31.0 TNF IL6 IL1B ELANE CXCL8
49 spinal cord injury 31.0 TNF IL6 CXCL8
50 heart disease 31.0 TNF THBD MPO IL6 IL1B ELN

Graphical network of the top 20 diseases related to Adult Respiratory Distress Syndrome:



Diseases related to Adult Respiratory Distress Syndrome
Sources

Symptoms & Phenotypes for Adult Respiratory Distress Syndrome

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Human phenotypes related to Adult Respiratory Distress Syndrome:

58 31 (show all 23)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 respiratory failure 58 31 frequent (33%) Frequent (79-30%) HP:0002878
2 tachypnea 58 31 frequent (33%) Frequent (79-30%) HP:0002789
3 respiratory distress 58 31 frequent (33%) Frequent (79-30%) HP:0002098
4 hypoxemia 58 31 frequent (33%) Frequent (79-30%) HP:0012418
5 pneumonia 58 31 frequent (33%) Frequent (79-30%) HP:0002090
6 elevated c-reactive protein level 58 31 frequent (33%) Frequent (79-30%) HP:0011227
7 pulmonary infiltrates 58 31 frequent (33%) Frequent (79-30%) HP:0002113
8 increased circulating surfactant protein level 58 31 frequent (33%) Frequent (79-30%) HP:0032094
9 increased circulating interleukin 6 31 frequent (33%) HP:0030783
10 fever 58 31 occasional (7.5%) Occasional (29-5%) HP:0001945
11 hemoptysis 58 31 occasional (7.5%) Occasional (29-5%) HP:0002105
12 sepsis 58 31 occasional (7.5%) Occasional (29-5%) HP:0100806
13 edema 58 31 occasional (7.5%) Occasional (29-5%) HP:0000969
14 acute pancreatitis 58 31 occasional (7.5%) Occasional (29-5%) HP:0001735
15 abnormality of tumor necrosis factor secretion 58 31 occasional (7.5%) Occasional (29-5%) HP:0011118
16 shock 58 31 occasional (7.5%) Occasional (29-5%) HP:0031273
17 diffuse alveolar hemorrhage 58 31 occasional (7.5%) Occasional (29-5%) HP:0025420
18 alcoholism 58 31 occasional (7.5%) Occasional (29-5%) HP:0030955
19 abnormal pulmonary interstitial morphology 31 occasional (7.5%) HP:0006530
20 dyspnea 58 Frequent (79-30%)
21 interstitial pulmonary abnormality 58 Occasional (29-5%)
22 increased serum interleukin-6 58 Frequent (79-30%)
23 abnormality of serum cytokine level 58 Frequent (79-30%)

UMLS symptoms related to Adult Respiratory Distress Syndrome:


dyspnea, hemoptysis, apnea, respiratory distress, cheyne-stokes respiration, coughing, hoarseness, labored breathing

MGI Mouse Phenotypes related to Adult Respiratory Distress Syndrome:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.16 ABCA3 ALOX5 ANGPT1 CP ELANE FGF7
2 cardiovascular system MP:0005385 10.15 ABCA3 ALOX5 ANGPT1 CP GJB2 IGHMBP2
3 growth/size/body region MP:0005378 10.13 ABCA3 ANGPT1 FGF7 GJB2 IGHMBP2 IL1B
4 immune system MP:0005387 9.97 ALOX5 ANGPT1 CP ELANE FGF7 GJB2
5 mortality/aging MP:0010768 9.83 ABCA3 ANGPT1 ELANE GJB2 IGHMBP2 IL1B
6 respiratory system MP:0005388 9.23 ABCA3 IGHMBP2 IL6 SFTPB SFTPC SFTPD
Sources

Drugs & Therapeutics for Adult Respiratory Distress Syndrome

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PubMed Health treatment related to Adult Respiratory Distress Syndrome: 62

ARDS is treated in a hospital's intensive care unit. Current treatment approaches focus on improving blood oxygen levels and providing supportive care. Doctors also will try to pinpoint and treat the underlying cause of the condition.

Drugs for Adult Respiratory Distress Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 400)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Propofol Approved, Investigational, Vet_approved Phase 4 2078-54-8 4943
2
Cisatracurium Approved Phase 4 96946-41-7 62887
3
Atracurium Approved, Experimental, Investigational Phase 4 64228-79-1 47319
4
Lidocaine Approved, Vet_approved Phase 4 137-58-6 3676
5
Rocuronium Approved Phase 4 119302-91-9, 143558-00-3 441290
6
Valsartan Approved, Investigational Phase 4 137862-53-4 60846
7
Ibuprofen Approved Phase 4 15687-27-1 3672
8
Dalteparin Approved Phase 4 9005-49-6
9
Tinzaparin Approved Phase 4 9041-08-1, 9005-49-6 25244225
10
Ketamine Approved, Vet_approved Phase 4 6740-88-1 3821
11
Caffeine Approved Phase 4 58-08-2 2519
12
Bivalirudin Approved, Investigational Phase 4 128270-60-0 16129704
13
Heparin Approved, Investigational Phase 4 9005-49-6 772 9812414
14 Poractant alfa Approved Phase 4 129069-19-8
15
Remifentanil Approved Phase 4 132875-61-7 60815
16
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 4 1177-87-3
17
Dexamethasone Approved, Investigational, Vet_approved Phase 4 50-02-2 5743
18
Spironolactone Approved Phase 4 1952-01-7, 52-01-7 5833
19
Iron Approved Phase 4 7439-89-6 23925 29936
20
Deferoxamine Approved, Investigational Phase 4 70-51-9 2973
21
Budesonide Approved Phase 4 51333-22-3 63006 5281004
22
Betamethasone Approved, Vet_approved Phase 4 378-44-9 9782
23 Sivelestat Investigational Phase 4 127373-66-4
24 Psychotropic Drugs Phase 4
25 GABA Modulators Phase 4
26 Anti-Anxiety Agents Phase 4
27 Neuromuscular Nondepolarizing Agents Phase 4
28 Cholinergic Antagonists Phase 4
29 Cholinergic Agents Phase 4
30 Anesthetics Phase 4
31 Neurotransmitter Agents Phase 4
32 Analgesics, Non-Narcotic Phase 4
33 Anesthetics, Intravenous Phase 4
34 Anesthetics, General Phase 4
35 Neuromuscular Blocking Agents Phase 4
36 Serine Proteinase Inhibitors Phase 4
37 Sodium Channel Blockers Phase 4
38 Anesthetics, Local Phase 4
39 Anti-Arrhythmia Agents Phase 4
40 Calcium, Dietary Phase 4
41 Cyclooxygenase Inhibitors Phase 4
42 Anti-Inflammatory Agents, Non-Steroidal Phase 4
43 Tin Fluorides Phase 4
44 Heparin, Low-Molecular-Weight Phase 4
45 Antithrombins Phase 4
46 Antithrombin III Phase 4
47 Anesthetics, Dissociative Phase 4
48 Excitatory Amino Acid Antagonists Phase 4
49
Glycopyrrolate Phase 4 596-51-0 3494
50
Piperidine Phase 4 110-89-4 8082

Interventional clinical trials:

(show top 50) (show all 1329)
# Name Status NCT ID Phase Drugs
1 Sleep Intervention During Acute Lung Injury Unknown status NCT01050699 Phase 4 Dexmedetomidine;Midazolam and Fentanyl
2 Effect of Treatment With Stress-Doses Glucocorticoid on Mortality in Patients With ARDS and Relative Adrenal Insufficiency Unknown status NCT00773058 Phase 4 hydrocortisone;placebo
3 Efficacy Evaluation of Surfactant Administration for Respiratory Distress Syndrome Treatment Via Laryngeal Mask Airway. A Randomized Controlled Trial Unknown status NCT01173237 Phase 4
4 Routine Administration of Surfactant/Budesonide to Prevent BPD in VLBW With RDS-A Double Blind Study Unknown status NCT03275415 Phase 4 budesonide;Saline
5 Impact of Fluid Resuscitation Therapy on Pulmonary Edema as Measured by Alveolar Fluid Clearance in Patients With Acute Respiratory Distress Syndrome (ARDS) Unknown status NCT01763853 Phase 4 4% albumin
6 Effects of NMBA on the Alteration of Transpulmonary Pressures at the Early Phase of ARDS Unknown status NCT01573715 Phase 4 NIMBEX;NIMBEX
7 Early Bubble CPAP (EBCPAP) in Very Low Birth Weight Infants (VLBWI) Unknown status NCT00368680 Phase 4
8 Efficacy of Rescue Surfactant Delivery Via Endotracheal Intubation (INSURE Technique) Versus Laryngeal Mask Airway (LMA) for Respiratory Distress Syndrome (RDS) in Preterm Neonates Unknown status NCT02164734 Phase 4 remifentanil
9 Comparative Trial of Two Strategies of RDS Treatment in Newborns With Birth Weight > 1500 Grams Unknown status NCT00277030 Phase 4 Surfactant
10 THE EFFECT OF SUSTAINED LUNG INFLATION MANEUVER APPLIED THROUGH NASAL PRONG ON EARLY AND LATE RESPIRATORY MORBIDITIES IN PRETERM INFANTS Unknown status NCT02887924 Phase 4
11 Prevention of Chronic Lung Disease (CLD) in Preterm Infants -A New Therapeutic Regimen Unknown status NCT00883532 Phase 4 budesonide;surfactant and air (placebo)
12 Propofol and Remifentanil Versus Midazolam and Remifentanil as Premedication Allowing Very Early Extubation After Surfactant Treatment in Preterm Neonates With Respiratory Distress Syndrome Unknown status NCT00797160 Phase 4 propofol
13 Functional Residual Capacity Guided Alveolar Recruitment Strategy in Patients With Acute Respiratory Failure After Cardiac Surgery Unknown status NCT01280019 Phase 4
14 A Multicentre, Randomized, Clinical Trial of Noninvasive Ventilation: Neurally Adjusted Ventilatory Assist (NAVA) vs. Pressure Support in Pediatric Acute Respiratory Failure - NINAVAPed Protocol Unknown status NCT01873521 Phase 4
15 Early Administration of Surfactant in Spontaneous Breathing (TAKE CARE) Versus InSurE (Intubation, Surfactant, Extubation) : A Pilot Study Unknown status NCT01329432 Phase 4
16 The Effect of Maternal Antenatal Steroid Administration on the Blood Flow Through the Pulmonary Artery in the Term Fetus; a Randomized Control Double Blinded Study Unknown status NCT02978976 Phase 4 Betamethasone;saline
17 the Study of Using Esophageal Pressure to Guide the PEEP Setting in Abdominal Hypertension Patients Who Undergoing Mechanical Ventilation Unknown status NCT01825304 Phase 4
18 Efficacy and Safety of Sivelestat Sodium Hydrate in Acute Lung Injury Associated With Systemic Inflammatory Response Syndrome, Compared With the Conventional Treatment in Japan Completed NCT00219375 Phase 4 Sivelestat sodium hydrate;Sivelestat sodium hydrate
19 Effects of Bolus Surfactant Therapy on Serial Peripheral Perfusion Index and Tissue Carbon Monoxide Measurements in Preterm Infants With Severe Respiratory Distress Syndrome Completed NCT01923844 Phase 4 exogenous surfactant
20 Comparative Study of the Use of Remifentanil Versus Morphine for Sedation and Analgesia of Premature Neonates During Mechanical Ventilation in the Treatment of Respiratory Distress Syndrome (RDS) Completed NCT00391105 Phase 4 Remifentanil
21 Effect of Early 48-hour Sevoflurane Inhalation on Gas Exchange and Inflammation in Patients Presenting With Acute Respiratory Distress Syndrome (ARDS) : a Monocentric, Prospective, Randomized Study. Completed NCT02166853 Phase 4 sevoflurane;midazolam
22 Effects Of A Recruitment Maneuver On Plasma Levels of sRAGE, The Soluble Form of The Receptor For Advanced Glycation End Products, In Patients With Diffuse Acute Respiratory Distress Syndrome (ARDS) Completed NCT01600651 Phase 4
23 Corticosteroid Mediates Acute Respiratory Distress Syndrome Via NLRP3 Inflammasome Signaling Pathway Completed NCT02819453 Phase 4 Methylprednisolone
24 A Comparative, Randomised Controlled Trial for Evaluating the Efficacy of Dexamethasone in the Treatment of Patients With Acute Respiratory Distress Syndrome Completed NCT01731795 Phase 4 Dexamethasone
25 The Study of Pharmacokinetics and Pharmacodynamics of a Loading Dose Cisatracurium in Critically Ill Patients Completed NCT03337373 Phase 4 cisatracurium
26 Assessment of the Cerebral Tissue Oxygenation and the Bioelectrical Brain Activity of Preterm Newborns During Administration of Two Different Surfactant Completed NCT01941524 Phase 4 Poractant alfa instillation;Beractant instillation
27 Rescue Surfactant for Respiratory Distress Syndrome (RDS) in Newborns: Comparing Efficacy of Delivery Via Laryngeal Mask Airway to Delivery by Endotracheal Intubation Completed NCT01042600 Phase 4
28 Comparison of Effectiveness of Nasal CPAP and Nasal IMV in Early Rescue Surfactant Treatment in Preterm Infants Completed NCT01741129 Phase 4
29 Premedication for Non-Emergency Endotracheal Intubation In the NICU Completed NCT01749501 Phase 4 Rocuronium
30 Synchronized Intermittent Mandatory Ventilation (SIMV) Versus Nasal Intermittent Positive Pressure Ventilation (NIPPV) In Preterm Infants With Respiratory Distress Completed NCT00486850 Phase 4
31 An International, Open, Randomized, Controlled Study to Evaluate the Efficacy of Combining Prophylactic Curosurf® With Early Nasal CPAP Versus Early Nasal CPAP Alone in Very Preterm Infants at Risk of Respiratory Distress Syndrome Completed NCT00501982 Phase 4 Poractant alfa (Curosurf®)
32 Laryngoscope Versus CMAC for Endotracheal Intubation in Patients Undergoing Emergent Airway Management Completed NCT01710891 Phase 4
33 Systematic Early Use of Neuromuscular Blocking Agents in ARDS Patients Completed NCT00299650 Phase 4 cisatracurium;Placebo;Cisatracurium besilate
34 A Multi-center, Post Marketing Surveillance Study to Monitor the Safety and Performance of the Barricaid® ARD in the Treatment of Back and Radicular Pain Caused by Primary Lumbar Disc Herniation Completed NCT01534065 Phase 4
35 Efficacy of Adding Budesonide to Poractant Alfa to Prevent Bronchopulmonary Dysplasia in Preterm Infants With Respiratory Distress Syndrome. Recruiting NCT03521063 Phase 4 Budesonide;Poractant Alfa;Saline
36 Effect of Inhalation Sedation With Sevoflurane Compared With Propofol on the Sepsis-related Acute Respiratory Distress Syndrome (ARDS) Course. Recruiting NCT04014218 Phase 4 Inhalation Sedation;Intravenous Sedation
37 PRAETORIAN-COVID: A Double-blind, Placebo-controlled Randomized Clinical Trial With Valsartan for PRevention of Acute rEspiraTORy dIstress Syndrome in hospitAlized patieNts With SARS-COV-2 (COVID-19) Infection Disease Recruiting NCT04335786 Phase 4 Valsartan (Diovan);Placebo oral tablet
38 Sedation With Sevoflurane Versus Propofol in Patients With Acute Respiratory Distress Syndrome Caused by COVID19 Infection Recruiting NCT04359862 Phase 4 Sevoflurane;Propofol
39 Lipid Ibuprofen Versus Standard of Care for Acute Hypoxemic Respiratory Failure Due to COVID-19: a Multicentre, Randomised, Controlled Trial Recruiting NCT04334629 Phase 4 Ibuprofen
40 Premedication for Less Invasive Surfactant Administration Recruiting NCT03735563 Phase 4 Ketamine;Fentanyl
41 Impact of the Administration of Intravenous or Paravertebral Lidocaine in Continuous Perfusion During the Intraoperative Period of Lung Resection Surgery on the Appearance of Postoperative Complications Recruiting NCT03905837 Phase 4 Lidocaine;Remifentanil
42 Life-threatening Acute Respiratory Failure in Children: to Breathe or Not to Breathe Spontaneously, That's the Question Recruiting NCT02902055 Phase 4 Neuromuscular Blocking Agents;Isotonic saline
43 Anticoagulation in Patients Suffering From COVID-19 Disease-The Anti-Co Trial Recruiting NCT04445935 Phase 4 Bivalirudin Injection;Standard treatment
44 Effect of Dexamethasone in Patients With ARDS and COVID-19 - Prospective, Multi-centre, Open-label, Parallel-group, Randomized Controlled Trial (REMED Trial) Recruiting NCT04663555 Phase 4 Dexamethasone
45 Oxygenation Targets in Cardiac Surgery Patients - a Before-and-after Study Active, not recruiting NCT04133740 Phase 4 Oxygen
46 Exogenous Surfactant in Very Preterm Neonates Presenting With Severe Respiratory Distress in Prevention of Bronchopulmonary Dysplasia Active, not recruiting NCT01039285 Phase 4 Curosurf
47 Nebulized Heparin vs. Placebo for the Treatment of COVID-19 Induced Lung Injury Enrolling by invitation NCT04397510 Phase 4 Heparin;0.9% Sodium-chloride
48 The Effect of Spironolactone on Oxygenation in Covid-19 ARDS Patients Not yet recruiting NCT04345887 Phase 4 Spironolactone 100mg;Placebo oral tablet
49 Comparison of Two Fraction Oxygen Inspired (FiO2) Thresholds for the Surfactant Administration in Preterm Infants With Respiratory Disease Syndrome: a Single-center Randomized Phase IV Clinical Trial Not yet recruiting NCT04199364 Phase 4 Poractant Alfa 80 mg/mL Intratracheal Suspension
50 Stress Assessment in Preterm Infants With Respiratory Distress Syndrome Treated or Not With an Analgesic Drug During the Traditional or the Less Invasive Method of Surfactant Therapy. Not yet recruiting NCT04073173 Phase 4 Analgesic, Opioid

Search NIH Clinical Center for Adult Respiratory Distress Syndrome

Inferred drug relations via UMLS 71 / NDF-RT 51 :


Acetylcysteine
Albumin Human, USP
ALBUMIN,HUMAN INJ
Epoprostenol
Epoprostenol Sodium
Methylprednisolone
methylprednisolone acetate
Methylprednisolone Sodium Succinate
Nitrous Oxide

Cochrane evidence based reviews: respiratory distress syndrome

Sources

Genetic Tests for Adult Respiratory Distress Syndrome

About this section
Sources

Anatomical Context for Adult Respiratory Distress Syndrome

About this section

MalaCards organs/tissues related to Adult Respiratory Distress Syndrome:

40
Lung, Endothelial, Neutrophil, Kidney, Brain, Bone Marrow, Liver
LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database

Cells/anatomical compartments in embryo or adult related to Adult Respiratory Distress Syndrome:
# Tissue Anatomical CompartmentCell Relevance
1 Lung Pulmonary Capillary Plexus Affected by disease
2 Lung Alveoli Alveolar Epithelial Type 1 Cells Affected by disease, potential therapeutic candidate
3 Lung Alveoli Alveolar Epithelial Type 2 Cells Affected by disease, potential therapeutic candidate
Sources

Publications for Adult Respiratory Distress Syndrome

About this section

Articles related to Adult Respiratory Distress Syndrome:

(show top 50) (show all 19731)
# Title Authors PMID Year
1
Alveolar dead-space response to activated protein C in acute respiratory distress syndrome. 54 61
20420733 2010
2
Nrf2 protects against airway disorders. 54 61
19646463 2010
3
Activation of the stress protein response inhibits the STAT1 signalling pathway and iNOS function in alveolar macrophages: role of Hsp90 and Hsp70. 61 54
20388761 2010
4
The interaction of soluble Tie2 with angiopoietins and pulmonary vascular permeability in septic and nonseptic critically ill patients. 61 54
19543148 2010
5
Recombinant angiotensin-converting enzyme 2 improves pulmonary blood flow and oxygenation in lipopolysaccharide-induced lung injury in piglets. 61 54
19851091 2010
6
Humanized monoclonal antibody against the chemokine CXCL-8 (IL-8) effectively prevents acute lung injury. 54 61
19909826 2010
7
Sivelestat (selective neutrophil elastase inhibitor) improves the mortality rate of sepsis associated with both acute respiratory distress syndrome and disseminated intravascular coagulation patients. 54 61
19487982 2010
8
Does activation of the FcgammaRIIa play a role in the pathogenesis of the acute lung injury/acute respiratory distress syndrome? 54 61
20088831 2010
9
Hepatocyte growth factor in exhaled breath and BAL fluid in sarcoidosis. 54 61
20461686 2010
10
Genetic polymorphisms of peptidase inhibitor 3 (elafin) are associated with acute respiratory distress syndrome. 61 54
19251943 2009
11
[Relationship between tumor necrosis factor beta gene polymorphism and acute respiratory distress syndrome after operation for esophageal carcinoma]. 54 61
19958618 2009
12
Evidence lost to treatment of critically-ill patients? 54 61
19940825 2009
13
Bench-to-bedside review: the role of nitric oxide in sepsis. 54 61
20477340 2009
14
Anti-chemokine autoantibody:chemokine immune complexes activate endothelial cells via IgG receptors. 54 61
19109244 2009
15
[Application of damage control theory on the trauma orthopaedic treatment]. 61 54
19705736 2009
16
Combined use of extracorporeal membrane oxygenation and activated protein C for severe acute respiratory distress syndrome and septic shock. 61 54
19577093 2009
17
Evolving practices in the management of acute kidney injury in the ICU (Intensive Care Unit). 54 61
19473627 2009
18
Neutrophil-derived IL-6 limits alveolar barrier disruption in experimental ventilator-induced lung injury. 61 54
19494331 2009
19
Functional variants of the human 5-lipoxygenase gene and their genetic diagnosis. 54 61
19446447 2009
20
Keratinocyte growth factor expression is suppressed in early acute lung injury/acute respiratory distress syndrome by smad and c-Abl pathways. 61 54
19325470 2009
21
L-selectin shedding in sepsis limits leukocyte mediated microvascular injury at remote sites. 54 61
19303986 2009
22
Induction of proinflammatory cytokines in primary human macrophages by influenza A virus (H5N1) is selectively regulated by IFN regulatory factor 3 and p38 MAPK. 54 61
19124752 2009
23
Plasma neutrophil elastase and elafin imbalance is associated with acute respiratory distress syndrome (ARDS) development. 61 54
19197381 2009
24
Recombinant production of a hybrid plasminogen activator composed of surfactant protein B and low-molecular-weight urokinase. 61 54
19132247 2008
25
Anakinra (IL-1R antagonist) lowers pulmonary artery pressure in a neonatal surfactant depleted piglet model. 54 61
18668691 2008
26
Surfactant protein-B polymorphisms and mortality in the acute respiratory distress syndrome. 61 54
18679120 2008
27
[Application of continuous veno-venous hemofiltration in patients with acute respiratory distress syndrome]. 54 61
19087678 2008
28
Successful management of postoperative acute respiratory distress syndrome in a patient with lung cancer. 54 61
18607685 2008
29
C5a and TNF-alpha up-regulate the expression of tissue factor in intra-alveolar neutrophils of patients with the acute respiratory distress syndrome. 61 54
18490736 2008
30
Factor V Leiden mutation is associated with improved 30-day survival in patients with acute respiratory distress syndrome. 54 61
18496379 2008
31
Usefulness of a selective neutrophil elastase inhibitor (sivelestat) in septic ARDS patients after gastrointestinal surgery. 61 54
18705309 2008
32
Different expression ratio of S100A8/A9 and S100A12 in acute and chronic lung diseases. 54 61
18164192 2008
33
Anti-interleukin-8 autoantibody:interleukin-8 immune complexes in acute lung injury/acute respiratory distress syndrome. 54 61
18260828 2008
34
Inhalation of activated protein C: A possible new adjunctive intervention in acute respiratory distress syndrome. 61 54
19707316 2007
35
Anti-KC autoantibody:KC complexes cause severe lung inflammation in mice via IgG receptors. 54 61
17585113 2007
36
Anti-IL-8 autoantibody:IL-8 immune complexes suppress spontaneous apoptosis of neutrophils. 61 54
17513455 2007
37
Functional genomics highlights differential induction of antiviral pathways in the lungs of SARS-CoV-infected macaques. 54 61
17696609 2007
38
From oxygen sensing to heart failure: role of thioredoxin. 61 54
17511584 2007
39
Neutrophil-derived S100A12 in acute lung injury and respiratory distress syndrome. 61 54
17414728 2007
40
Cell-based angiopoietin-1 gene therapy for acute lung injury. 54 61
17322110 2007
41
The importance of surfactant on the development of neonatal pulmonary diseases. 54 61
17505704 2007
42
Association of IL-8-251A/T polymorphism with incidence of Acute Respiratory Distress Syndrome (ARDS) and IL-8 synthesis after multiple trauma. 61 54
17498967 2007
43
[Prognostic significance of neutrophil elastase inhibitor in patients with acute lung injury and interstitial pneumonia]. 61 54
17419435 2007
44
Anti-interleukin 8 autoantibody:interleukin 8 immune complexes visualized by laser confocal microscopy in injured lung. 54 61
17516748 2007
45
Dihydroxyoctadecamonoenoate esters inhibit the neutrophil respiratory burst. 54 61
17435320 2007
46
Successful treatment of life-threatening melioidosis with activated protein C and meropenem. 54 61
17332913 2007
47
TNF-alpha increases tyrosine phosphorylation of vascular endothelial cadherin and opens the paracellular pathway through fyn activation in human lung endothelia. 61 54
16891393 2006
48
KL4-surfactant prevents hyperoxic and LPS-induced lung injury in mice. 61 54
16871629 2006
49
Role of TNFalpha in pulmonary pathophysiology. 54 61
17034639 2006
50
Release of soluble E-selectin from activated endothelial cells upon apoptosis. 54 61
17235725 2006
Sources

Variations for Adult Respiratory Distress Syndrome

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ClinVar genetic disease variations for Adult Respiratory Distress Syndrome:

6 (show all 13)
# Gene Name Type Significance ClinVarId dbSNP ID GRCh37 Pos GRCh38 Pos
1 RALGAPA1 NM_001346249.2(RALGAPA1):c.1126C>T (p.Arg376Ter) SNV Pathogenic 691794 rs1595416752 14:36217916-36217916 14:35748710-35748710
2 RALGAPA1 NM_001346249.2(RALGAPA1):c.6510del (p.Phe2170fs) Deletion Pathogenic 691795 rs1594878619 14:36096643-36096643 14:35627437-35627437
3 RALGAPA1 NM_001346249.2(RALGAPA1):c.610G>T (p.Glu204Ter) SNV Pathogenic 691796 rs1595446167 14:36226052-36226052 14:35756846-35756846
4 RALGAPA1 NM_001346249.2(RALGAPA1):c.7250C>G (p.Ser2417Ter) SNV Pathogenic 691797 rs1594642302 14:36041884-36041884 14:35572678-35572678
5 RALGAPA1 NM_001346249.2(RALGAPA1):c.4745A>G (p.Asn1582Ser) SNV Pathogenic 691798 rs1595085511 14:36143795-36143795 14:35674589-35674589
6 IGHMBP2 NM_002180.2(IGHMBP2):c.92G>A (p.Trp31Ter) SNV Pathogenic 242499 rs863224880 11:68673542-68673542 11:68906074-68906074
7 GJB2 NM_004004.6(GJB2):c.488T>C (p.Met163Thr) SNV Likely pathogenic 449488 rs1273330603 13:20763233-20763233 13:20189094-20189094
8 SYT2 NM_177402.5(SYT2):c.1084_1089del (p.Tyr362_Asp363del) Deletion Likely pathogenic 373966 rs1057518805 1:202566056-202566061 1:202596928-202596933
9 SFTPC NM_001317778.2(SFTPC):c.163C>T (p.Leu55Phe) SNV Likely pathogenic 598978 rs1563221666 8:22020207-22020207 8:22162694-22162694
10 ABCA3 NM_001089.3(ABCA3):c.614-2A>G SNV Likely pathogenic 598980 rs773223403 16:2369843-2369843 16:2319842-2319842
11 ABCA3 NM_001089.3(ABCA3):c.3200G>A (p.Gly1067Glu) SNV Uncertain significance 598979 rs1567339065 16:2336773-2336773 16:2286772-2286772
12 PMP22 NM_000304.4(PMP22):c.422T>G (p.Val141Gly) SNV Uncertain significance 373965 rs1057518804 17:15134295-15134295 17:15230978-15230978
13 DES NM_001927.4(DES):c.407T>A (p.Leu136His) SNV Uncertain significance 44261 rs397516695 2:220283591-220283591 2:219418869-219418869
Sources

Expression for Adult Respiratory Distress Syndrome

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Search GEO for disease gene expression data for Adult Respiratory Distress Syndrome.
Sources

Pathways for Adult Respiratory Distress Syndrome

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Pathways related to Adult Respiratory Distress Syndrome according to GeneCards Suite gene sharing:

(show all 40)
# Super pathways Score Top Affiliating Genes
1
Cytokine Signaling in Immune system 65
Show member pathways
 13.33 TNF IL6 IL1B FGF7 CXCL8 ANGPT1
2
Toll-Like receptor Signaling Pathways 64
Show member pathways
 12.7 TNF IL6 IL1B CXCL8 CP
3
Immune response IL-23 signaling pathway 23
Show member pathways
 12.57 TNF MPO IL6 IL1B ANGPT1
4
IL-17 Family Signaling Pathways 64
Show member pathways
 12.3 TNF IL6 IL1B CXCL8
5
Folate Metabolism 1
Show member pathways
 12.3 TNF MPO IL6 IL1B ALOX5
6
Toll Comparative Pathway 63
Show member pathways
 12.28 TNF IL6 IL1B CXCL8
7
Transcriptional misregulation in cancer 36
12.25 MPO IL6 ELANE CXCL8
8
Immune response IFN alpha/beta signaling pathway 23
Show member pathways
 12.25 TNF IL6 IL1B FGF7 CXCL8
9
NOD-like receptor signaling pathway 36
12.22 TNF IL6 IL1B CXCL8
10
Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways 1
12.16 TNF IL6 IL1B CXCL8
11
Bacterial infections in CF airways 23
Show member pathways
 12.11 TNF SFTPD IL6 IL1B CXCL8
12
Yersinia infection 36
12.07 TNF IL6 IL1B CXCL8
13
Spinal Cord Injury 1
11.99 TNF IL6 IL1B CXCL8
14
Amoebiasis 36
11.89 TNF IL6 IL1B CXCL8
15
Th1 Differentiation Pathway 64
Show member pathways
 11.73 TNF IL6 IL1B
16
Pertussis 36
11.73 TNF IL6 IL1B CXCL8
17
Dendritic Cells Developmental Lineage Pathway 64
11.71 TNF THBD IL6 IL1B
18
Interleukin-4 and 13 signaling 65
11.71 TNF IL6 IL1B CXCL8 ALOX5
19
Photodynamic therapy-induced NF-kB survival signaling 1
Show member pathways
 11.61 TNF IL6 IL1B CXCL8
20
AGE-RAGE signaling pathway in diabetic complications 36
11.55 TNF THBD IL6 IL1B CXCL8
21
Photodynamic therapy-induced AP-1 survival signaling. 1
11.54 TNF IL6 FGF7
22
Legionellosis 36
11.51 TNF IL6 IL1B CXCL8
23
Transcription_Role of VDR in regulation of genes involved in osteoporosis 23
11.48 TNF IL6 IL1B
24
Malaria 36
11.43 TNF IL6 IL1B CXCL8
25
Interleukin-10 signaling 65
11.4 TNF IL6 IL1B CXCL8
26
African trypanosomiasis 36
11.37 TNF IL6 IL1B
27
amb2 Integrin signaling 1
11.35 TNF MPO IL6 ELANE
28
IL-10 Pathway 63
11.34 TNF IL6 IL1B
29
Validated transcriptional targets of AP1 family members Fra1 and Fra2 1
11.32 THBD IL6 CXCL8
30
Rheumatoid arthritis 36
11.32 TNF IL6 IL1B CXCL8 ANGPT1
31
Development and heterogeneity of the ILC family 1
11.29 TNF IL6 IL1B
32
Antifolate resistance 36
11.27 TNF IL6 IL1B
33
Surfactant metabolism 65
Show member pathways
 11.26 SFTPD SFTPC SFTPB ABCA3
34
Cytokines and Inflammatory Response 1
11.23 TNF IL6 IL1B
35
Defective CSF2RA causes pulmonary surfactant metabolism dysfunction 4 (SMDP4) 65
Show member pathways
 11.15 SFTPD SFTPC SFTPB
36
Overview of nanoparticle effects 1
11.01 TNF IL6 CXCL8
37
Lung fibrosis 1
10.97 TNF SFTPC IL6 IL1B FGF7 ELN
38
G-protein signaling_Rap2B regulation pathway 23
10.92 TNF IL6 IL1B FGF7 ELN CXCL8
39
LDL Oxidation in Atherogenesis 63
10.9 TNF MPO IL1B
40
IL-9 Signaling Pathways and their Primary Biological Effects in Different Immune Cell Types 64
10.76 IL6 IL1B
Sources

GO Terms for Adult Respiratory Distress Syndrome

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Cellular components related to Adult Respiratory Distress Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.8 TNF SFTPD SFTPC SFTPB MPO IL6
2 extracellular space GO:0005615 9.5 TNF THBD SFTPD SFTPC SFTPB MPO
3 clathrin-coated endocytic vesicle GO:0045334 9.43 SFTPD SFTPC SFTPB
4 lamellar body GO:0042599 9.37 SFTPC SFTPB
5 alveolar lamellar body GO:0097208 9.33 SFTPC SFTPB ABCA3
6 multivesicular body lumen GO:0097486 9.32 SFTPC SFTPB

Biological processes related to Adult Respiratory Distress Syndrome according to GeneCards Suite gene sharing:

(show all 33)
# Name GO ID Score Top Affiliating Genes
1 inflammatory response GO:0006954 10 TNF IL6 IL1B CXCL8 ALOX5
2 defense response to bacterium GO:0042742 9.96 TNF SFTPD MPO ELANE
3 positive regulation of gene expression GO:0010628 9.95 TNF IL6 IL1B FGF7 CXCL8 ANGPT1
4 positive regulation of protein phosphorylation GO:0001934 9.93 TNF IL1B FGF7 ANGPT1
5 leukocyte migration GO:0050900 9.92 TNF THBD ELANE ANGPT1
6 cytokine-mediated signaling pathway GO:0019221 9.92 TNF IL6 IL1B CXCL8 ALOX5
7 cellular response to lipopolysaccharide GO:0071222 9.89 TNF IL6 IL1B CXCL8
8 animal organ morphogenesis GO:0009887 9.88 TNF SFTPB FGF7 ELN
9 response to glucocorticoid GO:0051384 9.81 TNF IL6 ABCA3
10 positive regulation of smooth muscle cell proliferation GO:0048661 9.79 TNF IL6 ELANE
11 humoral immune response GO:0006959 9.79 TNF IL6 ALOX5
12 response to lipopolysaccharide GO:0032496 9.77 THBD MPO IL1B GJB2 ELANE
13 positive regulation of phagocytosis GO:0050766 9.74 TNF SFTPD IL1B
14 regulation of insulin secretion GO:0050796 9.71 TNF IL6 IL1B ALOX5
15 regulation of I-kappaB kinase/NF-kappaB signaling GO:0043122 9.67 TNF IL1B ANGPT1
16 surfactant homeostasis GO:0043129 9.65 SFTPD ABCA3
17 negative regulation of chemokine production GO:0032682 9.65 IL6 ELANE
18 regulation of establishment of endothelial barrier GO:1903140 9.65 TNF IL1B
19 negative regulation of vascular wound healing GO:0061044 9.64 TNF ALOX5
20 negative regulation of lipid storage GO:0010888 9.64 TNF IL6
21 negative regulation of neurogenesis GO:0050768 9.63 TNF IL6 IL1B
22 positive regulation of interleukin-8 production GO:0032757 9.62 TNF IL6 IL1B ELANE
23 positive regulation of glial cell proliferation GO:0060252 9.61 TNF IL6 IL1B
24 negative regulation of cytokine production involved in immune response GO:0002719 9.6 TNF ANGPT1
25 positive regulation of fever generation GO:0031622 9.58 TNF IL1B
26 positive regulation of leukocyte adhesion to arterial endothelial cell GO:1904999 9.56 TNF ALOX5
27 sequestering of triglyceride GO:0030730 9.55 TNF IL1B
28 response to yeast GO:0001878 9.54 MPO ELANE
29 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.51 TNF IL1B
30 positive regulation of neuroinflammatory response GO:0150078 9.43 TNF IL6 IL1B
31 cellular protein metabolic process GO:0044267 9.43 SFTPD SFTPC SFTPB IL6 CP ABCA3
32 vascular endothelial growth factor production GO:0010573 9.33 TNF IL6 IL1B
33 respiratory gaseous exchange GO:0007585 8.92 SFTPD SFTPC SFTPB ELN

Molecular functions related to Adult Respiratory Distress Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 8.92 TNF IL6 IL1B CXCL8
Sources

Sources for Adult Respiratory Distress Syndrome

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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