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ALI
MCID: ADL010
MIFTS: 65

Adult Respiratory Distress Syndrome (ALI)

Categories: Blood diseases, Cardiovascular diseases, Rare diseases, Respiratory diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
Sources

Aliases & Classifications for Adult Respiratory Distress Syndrome

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MalaCards integrated aliases for Adult Respiratory Distress Syndrome:

Name: Adult Respiratory Distress Syndrome 12 52 15 32
Respiratory Distress Syndrome, Adult 74 52 43 71
Acute Respiratory Distress Syndrome 12 74 52 17
Ards 12 52 15 62
Non-Cardiogenic Pulmonary Edema 12 52 71
Acute Lung Injury 52 58 17
Shock Lung 12 52
Increased-Permeability Pulmonary Edema 52
Respiratory Distress Syndrome Adult 54
Acute Respiratory Distress 54
Stiff Lung 52
Adult Rds 12
Ali 52

Characteristics:

Orphanet epidemiological data:

58
acute lung injury
Prevalence: 1-5/10000 (Europe);

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Respiratory diseases Cardiovascular diseases Blood diseases
See all MalaCards categories (disease lists)
ICD10: 32
Orphanet: 58  
Rare respiratory diseases


External Ids:

Disease Ontology 12 DOID:11394
MeSH 43 D012128
NCIt 49 C3353
SNOMED-CT 67 67782005
ICD10 32 J80
MESH via Orphanet 44 D055371
UMLS via Orphanet 72 C0242488
Orphanet 58 ORPHA178320
UMLS 71 C0035222 C3241936
Sources

Summaries for Adult Respiratory Distress Syndrome

About this section
NIH Rare Diseases : 52 Acute respiratory distress syndrome (ARDS) is a life-threatening lung condition that prevents enough oxygen from getting to the lungs and into the blood. People who develop ARDS often are very ill with another disease or have major injuries. The condition leads to a buildup of fluid in the air sacs which prevents enough oxygen from passing into the bloodstream. Symptoms may include difficulty breathing, low blood pressure and organ failure, rapid breathing and shortness of breath.

MalaCards based summary : Adult Respiratory Distress Syndrome, also known as respiratory distress syndrome, adult, is related to pulmonary edema and toxic shock syndrome, and has symptoms including dyspnea, hemoptysis and apnea. An important gene associated with Adult Respiratory Distress Syndrome is CXCL8 (C-X-C Motif Chemokine Ligand 8), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Propofol and Atracurium have been mentioned in the context of this disorder. Affiliated tissues include Lung, and related phenotypes are fever and dyspnea

Disease Ontology : 12 A respiratory failure that results from diffuse injury to the endothelium of the lung (as in sepsis, chest trauma, massive blood transfusion, aspiration of the gastric contents, or pneumonia) and is characterized by pulmonary edema with an abnormally high amount of protein in the edematous fluid and by difficult rapid breathing and hypoxemia.

PubMed Health : 62 About ards: ARDS, or acute respiratory distress syndrome, is a lung condition that leads to low oxygen levels in the blood. ARDS can be life threatening because your body's organs need oxygen-rich blood to work well. People who develop ARDS often are very ill with another disease or have major injuries. They might already be in the hospital when they develop ARDS.

Wikipedia : 74 Acute respiratory distress syndrome (ARDS) is a type of respiratory failure characterized by rapid onset... more...

Sources

Related Diseases for Adult Respiratory Distress Syndrome

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Diseases in the Adult Respiratory Distress Syndrome family:

Adult Acute Respiratory Distress Syndrome

Diseases related to Adult Respiratory Distress Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 1152)
# Related Disease Score Top Affiliating Genes
1 pulmonary edema 31.5 TNF IL10 F2 CXCL8 CSF3 ACE
2 toxic shock syndrome 31.4 TNF IL6 IL1R1 IL10 CXCL8 CD14
3 aspiration pneumonia 31.3 IL6 F2 ACE
4 thrombophlebitis 31.1 TNF SERPINE1 F2
5 pancreatitis 31.1 TNF IL6 IL10 ELANE
6 acute pancreatitis 31.0 TNF PLA2G6 IL6 IL10 ELANE CXCL8
7 chickenpox 31.0 TNF IL6 IL10
8 congestive heart failure 31.0 TNF IL6 ANGPT2 ACE
9 pleurisy 31.0 TNF CXCL8 ALOX5
10 cryptogenic organizing pneumonia 31.0 TNF SFTPD SFTPC CXCL8
11 bronchopneumonia 31.0 TNF IL6 IL10 ELANE CXCL8
12 pulmonary fibrosis 31.0 SFTPD SFTPC SERPINE1 ELN ELANE CXCL8
13 cytomegalovirus infection 31.0 TNF IL6 CXCL8
14 fasciitis 31.0 TNF IL6 CXCL8
15 leptospirosis 31.0 TNF IL6 IL10 F2 CXCL8
16 compartment syndrome 31.0 TNF IL6 F2
17 neutropenia 31.0 TNF IL6 IL10 ELANE CXCL8 CSF3
18 status asthmaticus 30.9 IL1R1 IL10 ELANE CXCL8
19 autoimmune disease 30.9 TNF IL6 IL1R1 IL10 CXCL8
20 capillary leak syndrome 30.9 IL6 ELANE CXCL8
21 meningoencephalitis 30.9 TNF IL6 IL10
22 acute interstitial pneumonia 30.9 SFTPD SFTPC SFTPB
23 interstitial emphysema 30.9 SFTPD SFTPC SFTPB
24 allergic hypersensitivity disease 30.9 TNF SFTPD IL10 CXCL8 ALOX5
25 leishmaniasis 30.9 TNF IL6 IL10 CXCL8
26 cardiomyopathy, familial hypertrophic, 20 30.8 TNF IL6 ELN CXCL8
27 hemophagocytic lymphohistiocytosis 30.8 TNF IL10 CXCL8
28 paracoccidioidomycosis 30.8 TNF IL6 IL10
29 disseminated intravascular coagulation 30.8 TNF THBD SERPINE1 IL6 IL10 F2
30 extrinsic allergic alveolitis 30.8 SFTPD IL6 IL10 ELANE CXCL8
31 plague 30.8 TNF IL6 IL10
32 colitis 30.8 TNF IL6 IL10 CXCL8
33 plasmodium vivax malaria 30.8 TNF THBD IL6 IL10 ANGPT2
34 common cold 30.8 TNF IL6 IL1R1 IL10 CXCL8
35 cardiac rupture 30.8 TNF ELANE CXCL8
36 leprosy 3 30.7 TNF IL6 IL10 CXCL8
37 bronchopulmonary dysplasia 30.7 SFTPB ELANE CXCL8
38 cerebral aneurysms 30.7 ELN ELANE
39 myocarditis 30.7 TNF IL6 IL10 ACE
40 thrombophilia due to thrombin defect 30.7 THBD SERPINE1 F2
41 myeloma, multiple 30.7 TNF IL6 IL10 CXCL8 CSF3
42 aortic aneurysm, familial abdominal, 1 30.7 IL6 ELN ELANE ACE
43 pyelonephritis 30.7 TNF IL6 IL10 CXCL8 CSF3 ACE
44 intracranial hypertension 30.7 TNF SERPINE1 F2
45 viral pneumonia 30.7 TNF SFTPD IL6 IL10 CXCL8
46 limb ischemia 30.7 TNF SERPINE1 IL6 F2 ANGPT2 ACE
47 tuberculous meningitis 30.7 TNF CXCL8 ALOX5
48 vasculitis 30.7 TNF THBD IL6 IL10 ELANE
49 ileus 30.7 TNF IL6 IL10 F2
50 engraftment syndrome 30.7 CXCL8 CSF3

Graphical network of the top 20 diseases related to Adult Respiratory Distress Syndrome:



Diseases related to Adult Respiratory Distress Syndrome
Sources

Symptoms & Phenotypes for Adult Respiratory Distress Syndrome

About this section

Human phenotypes related to Adult Respiratory Distress Syndrome:

58 (show all 21)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 fever 58 Occasional (29-5%)
2 dyspnea 58 Frequent (79-30%)
3 edema 58 Occasional (29-5%)
4 pulmonary infiltrates 58 Frequent (79-30%)
5 hemoptysis 58 Occasional (29-5%)
6 sepsis 58 Occasional (29-5%)
7 respiratory failure 58 Frequent (79-30%)
8 tachypnea 58 Frequent (79-30%)
9 respiratory distress 58 Frequent (79-30%)
10 hypoxemia 58 Frequent (79-30%)
11 pneumonia 58 Frequent (79-30%)
12 interstitial pulmonary abnormality 58 Occasional (29-5%)
13 elevated c-reactive protein level 58 Frequent (79-30%)
14 increased circulating surfactant protein level 58 Frequent (79-30%)
15 acute pancreatitis 58 Occasional (29-5%)
16 abnormality of tumor necrosis factor secretion 58 Occasional (29-5%)
17 increased serum interleukin-6 58 Frequent (79-30%)
18 shock 58 Occasional (29-5%)
19 diffuse alveolar hemorrhage 58 Occasional (29-5%)
20 alcoholism 58 Occasional (29-5%)
21 abnormality of serum cytokine level 58 Frequent (79-30%)

UMLS symptoms related to Adult Respiratory Distress Syndrome:


dyspnea, hemoptysis, apnea, respiratory distress, cheyne-stokes respiration, coughing, hoarseness, labored breathing

MGI Mouse Phenotypes related to Adult Respiratory Distress Syndrome:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.25 ACE ALOX5 CD14 CSF3 ELANE F2
2 homeostasis/metabolism MP:0005376 10.24 ACE ALOX5 ANGPT2 CD14 ELANE F2
3 immune system MP:0005387 10.22 ACE ALOX5 ANGPT2 CD14 CSF3 ELANE
4 cardiovascular system MP:0005385 10.17 ACE ALOX5 ANGPT2 F2 IL10 IL1R1
5 mortality/aging MP:0010768 10.03 ACE ANGPT2 CD14 ELANE F2 IL10
6 adipose tissue MP:0005375 10 ACE ALOX5 CD14 IL1R1 IL6 SERPINE1
7 integument MP:0010771 9.96 ANGPT2 CSF3 ELANE F2 IL10 IL1R1
8 neoplasm MP:0002006 9.56 ACE ELANE IL10 IL1R1 IL6 SERPINE1
9 respiratory system MP:0005388 9.4 ANGPT2 CD14 F2 IL10 IL1R1 IL6
Sources

Drugs & Therapeutics for Adult Respiratory Distress Syndrome

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PubMed Health treatment related to Adult Respiratory Distress Syndrome: 62

ARDS is treated in a hospital's intensive care unit. Current treatment approaches focus on improving blood oxygen levels and providing supportive care. Doctors also will try to pinpoint and treat the underlying cause of the condition.

Drugs for Adult Respiratory Distress Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 516)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Propofol Approved, Investigational, Vet_approved Phase 4 2078-54-8 4943
2
Atracurium Approved, Experimental, Investigational Phase 4 64228-79-1 47319
3
Cisatracurium Approved Phase 4 96946-41-7
4
Carbon monoxide Approved, Investigational Phase 4 630-08-0 281
5
Heparin Approved, Investigational Phase 4 9005-49-6 46507594 772
6
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4 437-38-7 3345
7
Morphine Approved, Investigational Phase 4 57-27-2 5288826
8
Acetylcysteine Approved, Investigational Phase 4 616-91-1 12035
9
Desflurane Approved Phase 4 57041-67-5 42113
10
Ketamine Approved, Vet_approved Phase 4 6740-88-1 3821
11
Metformin Approved Phase 4 657-24-9 14219 4091
12
Prednisolone phosphate Approved, Vet_approved Phase 4 302-25-0
13
Methylprednisolone Approved, Vet_approved Phase 4 83-43-2 6741
14
Methylprednisolone hemisuccinate Approved Phase 4 2921-57-5
15 Prednisolone acetate Approved, Vet_approved Phase 4 52-21-1
16
Prednisolone Approved, Vet_approved Phase 4 50-24-8 5755
17
Lidocaine Approved, Vet_approved Phase 4 137-58-6 3676
18
Rocuronium Approved Phase 4 119302-91-9, 143558-00-3 441290
19
Valsartan Approved, Investigational Phase 4 137862-53-4 60846
20
Losartan Approved Phase 4 114798-26-4 3961
21
Midazolam Approved, Illicit Phase 4 59467-70-8 4192
22
Spironolactone Approved Phase 4 52-01-7, 1952-01-7 5833
23
Hydroxychloroquine Approved Phase 4 118-42-3 3652
24
Zinc Approved, Investigational Phase 4 7440-66-6 32051
25
Remifentanil Approved Phase 4 132875-61-7 60815
26
Selenium Approved, Investigational, Vet_approved Phase 4 7782-49-2
27
Tocopherol Approved, Investigational Phase 4 1406-66-2, 54-28-4 14986
28
Budesonide Approved Phase 4 51333-22-3 63006 5281004
29 Poractant alfa Approved Phase 4 129069-19-8
30 Beractant Approved Phase 4 108778-82-1
31
Betamethasone Approved, Vet_approved Phase 4 378-44-9 9782
32
Cysteine Approved, Nutraceutical Phase 4 52-90-4 5862
33
Glycine Approved, Nutraceutical, Vet_approved Phase 4 56-40-6 750
34
Vitamin C Approved, Nutraceutical Phase 4 50-81-7 5785 54670067
35
Vitamin A Approved, Nutraceutical, Vet_approved Phase 4 22737-96-8, 68-26-8, 11103-57-4 9904001 445354
36
Vitamin E Approved, Nutraceutical, Vet_approved Phase 4 59-02-9 14985
37 Sivelestat Investigational Phase 4 127373-66-4
38
Prednisolone hemisuccinate Experimental Phase 4 2920-86-7
39
BCG vaccine Investigational Phase 4
40
Camostat Experimental Phase 4 59721-28-7
41 Tocotrienol Investigational Phase 4 6829-55-6
42 Gastrointestinal Agents Phase 4
43 Antineoplastic Agents, Hormonal Phase 4
44 Neuroprotective Agents Phase 4
45 Antiemetics Phase 4
46 Fibrin Fibrinogen Degradation Products Phase 4
47 Plasma-lyte 148 Phase 4
48 Ophthalmic Solutions Phase 4
49 Adrenergic beta-Agonists Phase 4
50 Anesthetics, General Phase 4

Interventional clinical trials:

(show top 50) (show all 1756)
# Name Status NCT ID Phase Drugs
1 Effect of Treatment With Stress-Doses Glucocorticoid on Mortality in Patients With ARDS and Relative Adrenal Insufficiency Unknown status NCT00773058 Phase 4 hydrocortisone;placebo
2 Effects of NMBA on the Alteration of Transpulmonary Pressures at the Early Phase of ARDS Unknown status NCT01573715 Phase 4 NIMBEX;NIMBEX
3 Impact of Fluid Resuscitation Therapy on Pulmonary Edema as Measured by Alveolar Fluid Clearance in Patients With Acute Respiratory Distress Syndrome (ARDS) Unknown status NCT01763853 Phase 4 4% albumin
4 the Study of Using Esophageal Pressure to Guide the PEEP Setting in Abdominal Hypertension Patients Who Undergoing Mechanical Ventilation Unknown status NCT01825304 Phase 4
5 Functional Residual Capacity Guided Alveolar Recruitment Strategy in Patients With Acute Respiratory Failure After Cardiac Surgery Unknown status NCT01280019 Phase 4
6 Propofol and Remifentanil Versus Midazolam and Remifentanil as Premedication Allowing Very Early Extubation After Surfactant Treatment in Preterm Neonates With Respiratory Distress Syndrome Unknown status NCT00797160 Phase 4 propofol
7 Early Bubble CPAP (EBCPAP) in Very Low Birth Weight Infants (VLBWI) Unknown status NCT00368680 Phase 4
8 Efficacy Evaluation of Surfactant Administration for Respiratory Distress Syndrome Treatment Via Laryngeal Mask Airway. A Randomized Controlled Trial Unknown status NCT01173237 Phase 4
9 Comparative Trial of Two Strategies of RDS Treatment in Newborns With Birth Weight > 1500 Grams Unknown status NCT00277030 Phase 4 Surfactant
10 The Effect of 6-Methyl-Prednisolone on Organ Dysfunction and Mortality of Patients With Unresolving Multiple Organ Dysfunction Syndrome Unknown status NCT00127985 Phase 4 6-methyl-prednisolone
11 Prevention of Chronic Lung Disease (CLD) in Preterm Infants -A New Therapeutic Regimen Unknown status NCT00883532 Phase 4 budesonide;surfactant and air (placebo)
12 THE EFFECT OF SUSTAINED LUNG INFLATION MANEUVER APPLIED THROUGH NASAL PRONG ON EARLY AND LATE RESPIRATORY MORBIDITIES IN PRETERM INFANTS Unknown status NCT02887924 Phase 4
13 A Multicentre, Randomized, Clinical Trial of Noninvasive Ventilation: Neurally Adjusted Ventilatory Assist (NAVA) vs. Pressure Support in Pediatric Acute Respiratory Failure - NINAVAPed Protocol Unknown status NCT01873521 Phase 4
14 The Effect of Withholding Feeds During Red Blood Cell Transfusion on Development of TRAGI in Very Low Birth Weight Infants Unknown status NCT02132819 Phase 4
15 The Effects of High Doze Tranexamic Acid Application on Hemorrhage, Blood Transfusion, Fibrin Degradation Products, and Kidney Functions for Total Hip Arthroplasty Unknown status NCT02094066 Phase 4 tranexamic acid;serum physiologic
16 Impact of Various Sedation Regimens on the Incidence of Post-sedation Delirium in Patients Receiving Mechanical Ventilation Unknown status NCT02117726 Phase 4 Dexmedetomidine,midazolam;Propofol,midazolam
17 Evaluation of High-dose Corticosteroids on Microcirculation Alterations in Cardiac Surgery, by FMD (Flow Mediated vasoDilation), Near Infrared Spectrophotometry (NIRS) and Biological Analysis (Syndecan-1) Unknown status NCT02798068 Phase 4 Solu-medrol or placebo administration
18 Effect of Early 48-hour Sevoflurane Inhalation on Gas Exchange and Inflammation in Patients Presenting With Acute Respiratory Distress Syndrome (ARDS) : a Monocentric, Prospective, Randomized Study. Completed NCT02166853 Phase 4 sevoflurane;midazolam
19 Corticosteroid Mediates Acute Respiratory Distress Syndrome Via NLRP3 Inflammasome Signaling Pathway Completed NCT02819453 Phase 4 Methylprednisolone
20 A Comparative, Randomised Controlled Trial for Evaluating the Efficacy of Dexamethasone in the Treatment of Patients With Acute Respiratory Distress Syndrome Completed NCT01731795 Phase 4 Dexamethasone
21 Effects Of A Recruitment Maneuver On Plasma Levels of sRAGE, The Soluble Form of The Receptor For Advanced Glycation End Products, In Patients With Diffuse Acute Respiratory Distress Syndrome (ARDS) Completed NCT01600651 Phase 4
22 The Study of Pharmacokinetics and Pharmacodynamics of a Loading Dose Cisatracurium in Critically Ill Patients Completed NCT03337373 Phase 4 cisatracurium
23 Efficacy and Safety of Sivelestat Sodium Hydrate in Acute Lung Injury Associated With Systemic Inflammatory Response Syndrome, Compared With the Conventional Treatment in Japan Completed NCT00219375 Phase 4 Sivelestat sodium hydrate;Sivelestat sodium hydrate
24 Comparison of Effectiveness of Nasal CPAP and Nasal IMV in Early Rescue Surfactant Treatment in Preterm Infants Completed NCT01741129 Phase 4
25 Effect of Perioperative Lung Protective Strategies on the Occurrence of Postoperative Pulmonary Complications in Patients Undergoing Lumbar Spinal Surgery in the Prone Position Completed NCT02373475 Phase 4
26 Assessment of the Cerebral Tissue Oxygenation and the Bioelectrical Brain Activity of Preterm Newborns During Administration of Two Different Surfactant Completed NCT01941524 Phase 4 Poractant alfa instillation;Beractant instillation
27 Effect of Steroids Given Over 24 Hours on Cytokine Release and Urinary Desmosine Levels in Patients Undergoing Bilateral Total Knee Replacement Completed NCT01399268 Phase 4 Hydrocortisone;Saline
28 Influence of N-Acetylcysteine on Morbidity, Oxygenation and Cytokine Levels in Partial or Total Esophagectomy for Cancer. A Multicenter, Prospective, Randomised Double Blind, Placebo-controlled Study Completed NCT00512265 Phase 4 n-acetylcysteine;250mL glucose 5%
29 Restrictive vs. Liberal Oxygen Therapy for Trauma Patients. PILOT: The TRAUMOX Trial Completed NCT03491644 Phase 4 Titrated Oxygen;Liberal Oxygen
30 Comparative Study of the Use of Remifentanil Versus Morphine for Sedation and Analgesia of Premature Neonates During Mechanical Ventilation in the Treatment of Respiratory Distress Syndrome (RDS) Completed NCT00391105 Phase 4 Remifentanil
31 An International, Open, Randomized, Controlled Study to Evaluate the Efficacy of Combining Prophylactic Curosurf® With Early Nasal CPAP Versus Early Nasal CPAP Alone in Very Preterm Infants at Risk of Respiratory Distress Syndrome Completed NCT00501982 Phase 4 Poractant alfa (Curosurf®)
32 Synchronized Intermittent Mandatory Ventilation (SIMV) Versus Nasal Intermittent Positive Pressure Ventilation (NIPPV) In Preterm Infants With Respiratory Distress Completed NCT00486850 Phase 4
33 Effects of Bolus Surfactant Therapy on Serial Peripheral Perfusion Index and Tissue Carbon Monoxide Measurements in Preterm Infants With Severe Respiratory Distress Syndrome Completed NCT01923844 Phase 4 exogenous surfactant
34 Premedication for Non-Emergency Endotracheal Intubation In the NICU Completed NCT01749501 Phase 4 Rocuronium
35 Effect of Adding Metformin to Insulin Therapy in Pregnant Women With Type I Diabetes as Regards Pregnancy Outcome Completed NCT03928340 Phase 4 Metformin;Insulin
36 Supportive Measures in Treatment of Aluminum Phosphide Poisoning as a Trial to Reduce Mortality at Assiut University Hospital Completed NCT03879356 Phase 4 N-acetyl cysteine
37 Rescue Surfactant for Respiratory Distress Syndrome (RDS) in Newborns: Comparing Efficacy of Delivery Via Laryngeal Mask Airway to Delivery by Endotracheal Intubation Completed NCT01042600 Phase 4
38 STUDY OF PULMONARY AND SYSTEMIC INFLAMMATORY RESPONSE SECONDARY TO LUNG RESECTION SURGERY USING INTRAVENOUS ANESTHESIA VERSUS INHALATION ANESTHESIA WITH HALOGENATED AGENTS Completed NCT02168751 Phase 4 propofol;Sevoflurane
39 ON Pump vs OFF Pump Myocardial Revascularization in High Risk Patients: a Randomized Study Completed NCT01290952 Phase 4
40 Evaluating Fluid Strategies in Thoracic Surgery Patients Utilizing a Goal Directed Approach Completed NCT02135146 Phase 4 Plasmalyte 3ml/kg/hr group;Plasmalyte 6ml/kg/hr group
41 Investigating Nutritional Therapy With EPA, GLA and Antioxidants Role in Sepsis Treatment-INTERSEPT STUDY Completed NCT00329680 Phase 4
42 Systematic Early Use of Neuromuscular Blocking Agents in ARDS Patients Completed NCT00299650 Phase 4 cisatracurium;Placebo;Cisatracurium besilate
43 Recruitment Maneuver Increases Oxygenation After Intubation in Hypoxemic ICU Patients: a Randomized Controlled Study Completed NCT01014299 Phase 4
44 Laryngoscope Versus CMAC for Endotracheal Intubation in Patients Undergoing Emergent Airway Management Completed NCT01710891 Phase 4
45 Effect Of Ketamine Infusion On Oxygenation And Ventilation Mechanics In Patients With Chronic Obstructive Pulmonary Disease Applied One Lung Ventilation Completed NCT02962999 Phase 4 Ketamine;Saline
46 Prospective Validation of a Plasma Transfusion Dosing Algorithm in Patients With Chronic Liver Disease Completed NCT02366845 Phase 4
47 Efficacy of Nebulized Heparin and Salbutamol in Mechanically Ventilated Patients With Acute Exacerbation Chronic Obstructive Pulmonary Disease: a Randomized Clinical Trial Completed NCT03333395 Phase 4 Nebulized heparin and salbutamol;Nebulized salbutamol
48 PRO-DEFENSE: Propofol Versus Dexmedetomidine for Sedation in Mechanically Ventilated Patients With Sepsis Completed NCT02203019 Phase 4 Propofol;Dexmedetomidine;Fentanyl
49 Perioperative Fluid Treatment in Colorectal Surgery Completed NCT03537989 Phase 4 Saline
50 Effect of Inhalation Sedation With Sevoflurane Compared With Propofol on the Sepsis-related Acute Respiratory Distress Syndrome (ARDS) Course. Recruiting NCT04014218 Phase 4 Inhalation Sedation;Intravenous Sedation

Search NIH Clinical Center for Adult Respiratory Distress Syndrome

Inferred drug relations via UMLS 71 / NDF-RT 50 :


Acetylcysteine
Albumin Human, USP
ALBUMIN,HUMAN INJ
Epoprostenol
Epoprostenol Sodium
Methylprednisolone
methylprednisolone acetate
Methylprednisolone Sodium Succinate
Nitrous Oxide

Cochrane evidence based reviews: respiratory distress syndrome, adult

Sources

Genetic Tests for Adult Respiratory Distress Syndrome

About this section
Sources

Anatomical Context for Adult Respiratory Distress Syndrome

About this section

MalaCards organs/tissues related to Adult Respiratory Distress Syndrome:

40
Lung, Neutrophil, Liver, Endothelial, Heart, Kidney, Testes
LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database

Cells/anatomical compartments in embryo or adult related to Adult Respiratory Distress Syndrome:
# Tissue Anatomical CompartmentCell Relevance
1 Lung Pulmonary Capillary Plexus Affected by disease
2 Lung Alveoli Alveolar Epithelial Type 1 Cells Affected by disease, potential therapeutic candidate
3 Lung Alveoli Alveolar Epithelial Type 2 Cells Affected by disease, potential therapeutic candidate
Sources

Publications for Adult Respiratory Distress Syndrome

About this section

Articles related to Adult Respiratory Distress Syndrome:

(show top 50) (show all 4355)
# Title Authors PMID Year
1
Association of IL-8-251A/T polymorphism with incidence of Acute Respiratory Distress Syndrome (ARDS) and IL-8 synthesis after multiple trauma. 61 54
17498967 2007
2
Copper stimulates the synthesis and release of interleukin-8 in human endothelial cells: a possible early role in systemic inflammatory responses. 54 61
12865660 2003
3
Anti-inflammatory activity of neutrophil elastase inhibitors. 61 54
12833649 2003
4
Phospholipase A2 is present in meconium and inhibits the activity of pulmonary surfactant: an in vitro study. 61 54
11332933 2001
5
Anti-interleukin-8 autoantibody in the tracheobronchial aspirate of infants with chronic lung disease. 54 61
11207999 2001
6
Levels of IL-8 and myeloperoxidase in the lungs of pneumonia patients. 61 54
11269653 2001
7
Inhaled porcine pancreatic elastase causes bronchoconstriction via a bradykinin-mediated mechanism. 54 61
11007574 2000
8
Interleukin-8 expression by fetal and neonatal pulmonary cells in hyaline membrane disease and amniotic infection. 54 61
10960493 2000
9
CXCR2 stimulation primes CXCR1 [Ca2+]i responses to IL-8 in human neutrophils. 54 61
10588510 1999
10
Pulmonary surfactant in health and human lung diseases: state of the art. 61 54
10445627 1999
11
Upregulated tumor necrosis factor-alpha gene expression in the hypoplastic lung in patients with congenital diaphragmatic hernia. 54 61
9880689 1998
12
Stimulation of inflammatory markers after blunt trauma. 61 54
9692580 1998
13
Cytokine release and mitogenic activity in the viridans streptococcal shock syndrome. 61 54
9619375 1998
14
Effect of PDE4 inhibitors on zymosan-induced IL-8 release from human neutrophils: synergism with prostanoids and salbutamol. 61 54
9559913 1998
15
Biochemical and pharmacological characterization of FR134043, a novel elastase inhibitor. 54 61
9592030 1998
16
Lipopolysaccharide-induced NF-kappaB activation and cytokine release in human alveolar macrophages is PKC-independent and TK- and PC-PLC-dependent. 54 61
9490656 1998
17
Biochemical and pharmacological characterization of FK706, a novel elastase inhibitor. 61 54
9389382 1997
18
Relative production of tumour necrosis factor alpha and interleukin 10 in adult respiratory distress syndrome. 61 54
9176536 1997
19
Protein kinase inhibitor attenuates an increase in endothelial monolayer permeability induced by tumour necrosis factor-alpha. 61 54
9424406 1997
20
Studies on the interaction of IL-8 with human plasma alpha 2-macroglobulin: evidence for the presence of IL-8 complexed to alpha 2-macroglobulin in lung fluids of patients with adult respiratory distress syndrome. 54 61
9029135 1997
21
The regional production of cytokines and lactate in sepsis-related multiple organ failure. 54 61
9001289 1997
22
Secretory leukoprotease inhibitor: partnering alpha 1-proteinase inhibitor to combat pulmonary inflammation. 61 54
8994529 1996
23
Interleukin-8 and adult respiratory distress syndrome. 61 54
8968789 1996
24
Sustained high levels of circulatory interleukin-8 are associated with a poor outcome in patients with adult respiratory distress syndrome. 54 61
8968796 1996
25
Tumor necrosis factor alpha (TNF alpha)-induced ICAM-1 surface expression in airway epithelial cells in vitro: possible signal transduction mechanisms. 54 61
8906209 1996
26
Anti-IL-8 autoantibodies in alveolar fluid from patients with the adult respiratory distress syndrome. 54 61
8805676 1996
27
The association between mortality rates and decreased concentrations of interleukin-10 and interleukin-1 receptor antagonist in the lung fluids of patients with the adult respiratory distress syndrome. 61 54
8686976 1996
28
Detection of IL-5 and IL-1 receptor antagonist in bronchoalveolar lavage fluid in acute eosinophilic pneumonia. 61 54
8648034 1996
29
[High concentrations of interleukin-8 in bronchoalveolar lavage fluid from a patient with adult respiratory distress syndrome]. 61 54
8753113 1996
30
The role of cytokines in human lung fibrosis. 54 61
8680382 1996
31
Cytokines in human lung fibrosis. 61 54
8678788 1996
32
Elastin fibers and the diagnosis of bacterial pneumonia in the adult respiratory distress syndrome. 61 54
7587258 1995
33
GRO alpha and interleukin-8 in Pneumocystis carinii or bacterial pneumonia and adult respiratory distress syndrome. 54 61
7582292 1995
34
Influence of heparin thromboprophylaxis on plasma leucocyte elastase levels following lobectomy for lung carcinoma. 61 54
7578893 1995
35
Relationship between alpha-tocopherol and polymorphonuclear leukocyte elastase in septic adult respiratory distress syndrome. 61 54
7582866 1995
36
Bronchoalveolar lavage fluid phospholipase A2 activities are increased in human adult respiratory distress syndrome. 54 61
7631805 1995
37
Interleukin-8 increases endothelial permeability independent of neutrophils. 61 54
7636916 1995
38
The value of polymorphonuclear elastase in adult respiratory distress syndrome. 54 61
7554278 1995
39
Immunosuppressive properties of surfactant and plasma on alveolar macrophages. 61 54
7897303 1995
40
Plasma interleukin 8 and polymorphonuclear leukocyte elastase concentrations in patients with septic shock. 61 54
7583359 1995
41
Use of elastin fibre detection in the diagnosis of ventilator associated pneumonia. 61 54
7886642 1995
42
The role of neutrophil elastase in chronic inflammation. 54 61
7952645 1994
43
Prophylactic treatment in the adult respiratory distress syndrome. 61 54
7613495 1994
44
Leukotrienes and alpha tumor necrosis factor levels in the bronchoalveolar lavage fluid of patient at risk for the adult respiratory distress syndrome. 54 61
7808646 1994
45
Tumor necrosis factor-alpha-induced inhibition of phosphatidylcholine synthesis by human type II pneumocytes is partially mediated by prostaglandins. 61 54
8040266 1994
46
[Soluble thrombomodulin: as a marker of endothelial injury]. 61 54
8051797 1994
47
Effect of pentoxifylline and somatostatin on tumour necrosis factor production by human pulmonary macrophages. 61 54
7834820 1994
48
Significance of alpha-tocopherol and interleukin 8 in septic adult respiratory distress syndrome. 61 54
8091005 1994
49
Effect of pentoxifylline on the inhibition of surfactant synthesis induced by TNF-alpha in human type II pneumocytes. 61 54
8118639 1994
50
High levels of interleukin-8 in the blood and alveolar spaces of patients with pneumonia and adult respiratory distress syndrome. 54 61
8406851 1993
Sources

Variations for Adult Respiratory Distress Syndrome

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Expression for Adult Respiratory Distress Syndrome

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Search GEO for disease gene expression data for Adult Respiratory Distress Syndrome.
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Pathways for Adult Respiratory Distress Syndrome

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Pathways related to Adult Respiratory Distress Syndrome according to GeneCards Suite gene sharing:

(show top 50) (show all 52)
# Super pathways Score Top Affiliating Genes
1
Innate Immune System 65
Show member pathways
 14.05 TNF PLA2G6 IL6 IL1R1 IL10 ELANE
2
ERK Signaling 63
Show member pathways
 13.83 TNF IL6 IL1R1 IL10 ELN CXCL8
3
PEDF Induced Signaling 63
Show member pathways
 13.64 TNF PLA2G6 IL6 IL1R1 IL10 F2
4
Akt Signaling 63
Show member pathways
 13.42 TNF IL6 IL1R1 IL10 CXCL8 CXCL1
5
Cytokine Signaling in Immune system 65
Show member pathways
 13.37 TNF IL6 IL1R1 IL10 CXCL8 CXCL1
6
PAK Pathway 63
Show member pathways
 13.33 TNF PLA2G6 IL6 IL1R1 IL10 CXCL8
7
Toll-like Receptor Signaling Pathway 36 1
Show member pathways
 13.09 TNF SFTPD SERPINE1 IL6 IL10 CXCL8
8
Human cytomegalovirus infection 36
Show member pathways
 12.95 TNF IL6 IL1R1 CXCL8 CXCL1 ANGPT2
9
Toll-Like receptor Signaling Pathways 64
Show member pathways
 12.75 TNF SERPINE1 IL6 IL1R1 CXCL8 CD14
10
Immune response IL-23 signaling pathway 22
Show member pathways
 12.59 TNF IL6 IL10 F2 CXCL1 CD14
11
Shigellosis 36
12.39 TNF IL1R1 CXCL8 CD14
12
IL-17 Family Signaling Pathways 64
Show member pathways
 12.37 TNF IL6 CXCL8 CXCL1 CSF3
13
Chemokine Superfamily: Human/Mouse Ligand-Receptor Interactions 64
Show member pathways
 12.36 TNF IL6 IL10 CXCL8 CXCL1
14
Toll Comparative Pathway 63
Show member pathways
 12.35 TNF IL6 IL1R1 CXCL8 CD14
15
Folate Metabolism 1
Show member pathways
 12.35 TNF SERPINE1 IL6 F2 ALOX5
16
Salmonella infection (KEGG) 36
12.32 TNF IL6 CXCL8 CD14
17
Pathogenic Escherichia coli infection 36
12.29 TNF IL6 IL1R1 F2 CXCL8
18
Transcriptional misregulation in cancer 36
12.28 IL6 ELANE CXCL8 CD14
19
Diseases associated with the TLR signaling cascade 65
Show member pathways
 12.28 TNF IL6 CXCL8 CD14
20
NOD-like receptor signaling pathway 36
12.25 TNF IL6 CXCL8 CXCL1
21
Tuberculosis 36
12.25 TNF IL6 IL10 CD14
22
Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways 1
12.19 TNF IL6 IL10 CXCL8
23
Bacterial infections in CF airways 22
Show member pathways
 12.13 TNF SFTPD IL6 IL1R1 CXCL8 CD14
24
Hematopoietic Stem Cells and Lineage-specific Markers 64
12.05 TNF IL6 IL10 CSF3 CD14
25
Yersinia infection 36
12.04 TNF IL6 IL10 CXCL8
26
Interleukin-4 and 13 signaling 65
12.04 TNF IL6 IL10 CXCL8 ALOX5
27
Senescence and Autophagy in Cancer 1
11.98 SERPINE1 IL6 CXCL8 CXCL1
28
NF-kappa B signaling pathway 36
11.98 TNF IL1R1 CXCL8 CXCL1 CD14
29
AGE-RAGE signaling pathway in diabetic complications 36
11.96 TNF THBD SERPINE1 IL6 CXCL8
30
Hematopoietic cell lineage 36
11.94 TNF IL6 IL1R1 CSF3 CD14
31
Rheumatoid arthritis 36
11.91 TNF IL6 CXCL8 CXCL1
32
Cytokine production by Th17 cells in CF (Mouse model) 22
Show member pathways
 11.9 IL6 CXCL8 CXCL1 CSF3 CD14
33
Spinal Cord Injury 1
11.88 TNF PLA2G6 IL6 IL1R1 CXCL8 CXCL1
34
Innate Lymphoid Cells Differentiation 64
11.79 TNF IL1R1 IL10
35
Pertussis 36
11.76 TNF IL6 IL10 CXCL8 CD14
36
Dendritic Cells Developmental Lineage Pathway 64
11.72 TNF THBD IL6 IL10 CD14
37
Photodynamic therapy-induced NF-kB survival signaling 1
Show member pathways
 11.68 TNF IL6 CXCL8
38
Transcription_NF-kB signaling pathway 22
11.6 TNF IL1R1 CD14
39
Legionellosis 36
11.56 TNF IL6 CXCL8 CXCL1 CD14
40
amb2 Integrin signaling 1
11.54 TNF IL6 ELANE
41
Amoebiasis 36
11.51 TNF IL6 IL1R1 IL10 CXCL8 CXCL1
42
Surfactant metabolism 65
Show member pathways
 11.49 SFTPD SFTPC SFTPB
43
Malaria 36
11.47 TNF IL6 IL10 CXCL8 CSF3
44
Lung fibrosis 1
11.43 TNF SFTPC IL6 ELN CXCL8 CSF3
45
IL-10 Pathway 63
11.42 TNF IL6 IL10 CD14
46
African trypanosomiasis 36
11.41 TNF IL6 IL10
47
Validated transcriptional targets of AP1 family members Fra1 and Fra2 1
11.37 THBD IL6 CXCL8
48
Defective CSF2RA causes pulmonary surfactant metabolism dysfunction 4 (SMDP4) 65
Show member pathways
 11.22 SFTPD SFTPC SFTPB
49
Cytokines and Inflammatory Response 1
11.12 TNF IL6 IL10 CXCL1 CSF3
50
Overview of nanoparticle effects 1
11.07 TNF IL6 CXCL8
Sources

GO Terms for Adult Respiratory Distress Syndrome

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Cellular components related to Adult Respiratory Distress Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.91 TNF SFTPD SFTPC SFTPB SERPINE1 IL6
2 collagen-containing extracellular matrix GO:0062023 9.72 SERPINE1 F2 ELN ELANE ANGPT2
3 external side of plasma membrane GO:0009897 9.63 TNF THBD IL1R1 F2 CD14 ACE
4 extracellular space GO:0005615 9.58 TNF THBD SFTPD SFTPC SFTPB SERPINE1
5 lamellar body GO:0042599 9.43 SFTPC SFTPB
6 clathrin-coated endocytic vesicle GO:0045334 9.43 SFTPD SFTPC SFTPB
7 multivesicular body lumen GO:0097486 9.4 SFTPC SFTPB
8 alveolar lamellar body GO:0097208 9.37 SFTPC SFTPB

Biological processes related to Adult Respiratory Distress Syndrome according to GeneCards Suite gene sharing:

(show all 31)
# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.95 TNF IL6 IL1R1 IL10 CXCL8 CXCL1
2 response to lipopolysaccharide GO:0032496 9.9 THBD IL10 ELANE CD14
3 cellular protein metabolic process GO:0044267 9.89 SFTPD SFTPC SFTPB IL6 F2
4 leukocyte migration GO:0050900 9.88 TNF THBD F2 ELANE ANGPT2
5 positive regulation of DNA-binding transcription factor activity GO:0051091 9.83 TNF IL6 IL10 CSF3
6 antimicrobial humoral immune response mediated by antimicrobial peptide GO:0061844 9.81 F2 CXCL8 CXCL1
7 response to glucocorticoid GO:0051384 9.81 TNF IL6 IL10
8 inflammatory response GO:0006954 9.8 TNF IL6 IL1R1 CXCL8 CXCL1 CD14
9 positive regulation of smooth muscle cell proliferation GO:0048661 9.79 TNF IL6 ELANE
10 humoral immune response GO:0006959 9.79 TNF IL6 ALOX5
11 positive regulation of interferon-gamma production GO:0032729 9.76 TNF IL1R1 CD14
12 positive regulation of cytokine secretion GO:0050715 9.71 TNF IL10 CD14
13 leukocyte chemotaxis GO:0030595 9.69 IL10 CXCL8 CXCL1
14 leukocyte migration involved in inflammatory response GO:0002523 9.65 ELANE ALOX5
15 negative regulation of lipid storage GO:0010888 9.65 TNF IL6
16 negative regulation of platelet activation GO:0010544 9.64 THBD F2
17 endothelial cell apoptotic process GO:0072577 9.63 TNF IL10
18 response to molecule of bacterial origin GO:0002237 9.63 IL10 CXCL8 CD14
19 neutrophil mediated immunity GO:0002446 9.62 IL6 ACE
20 respiratory gaseous exchange GO:0007585 9.62 SFTPD SFTPC SFTPB ELN
21 negative regulation of cytokine production involved in immune response GO:0002719 9.61 TNF IL10
22 negative regulation of fibrinolysis GO:0051918 9.61 THBD SERPINE1 F2
23 negative regulation of cytokine secretion involved in immune response GO:0002740 9.59 TNF IL10
24 positive regulation of leukocyte adhesion to arterial endothelial cell GO:1904999 9.58 TNF ALOX5
25 neutrophil mediated killing of gram-negative bacterium GO:0070945 9.57 F2 ELANE
26 negative regulation of chemokine biosynthetic process GO:0045079 9.56 IL6 ELANE
27 cytokine-mediated signaling pathway GO:0019221 9.56 TNF IL6 IL1R1 IL10 CXCL8 CXCL1
28 receptor biosynthetic process GO:0032800 9.55 TNF IL10
29 negative regulation of vascular wound healing GO:0061044 9.54 TNF SERPINE1 ALOX5
30 positive regulation of JAK-STAT cascade GO:0046427 9.46 TNF IL6 IL10 F2
31 cellular response to lipopolysaccharide GO:0071222 9.23 TNF SERPINE1 IL6 IL10 CXCL8 CXCL1

Molecular functions related to Adult Respiratory Distress Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protease binding GO:0002020 9.46 TNF SERPINE1 IL1R1 ELANE
2 lipopolysaccharide binding GO:0001530 9.43 SFTPD F2 CD14
3 growth factor activity GO:0008083 9.35 IL6 IL10 F2 CXCL1 CSF3
4 cytokine activity GO:0005125 9.1 TNF IL6 IL10 CXCL8 CXCL1 CSF3
Sources

Sources for Adult Respiratory Distress Syndrome

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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