ATLL
MCID: ADL017
MIFTS: 56

Adult T-Cell Leukemia (ATLL)

Categories: Blood diseases, Cancer diseases, Immune diseases, Infectious diseases, Rare diseases, Skin diseases

Aliases & Classifications for Adult T-Cell Leukemia

MalaCards integrated aliases for Adult T-Cell Leukemia:

Name: Adult T-Cell Leukemia 12 36 15 37
Adult T-Cell Leukemia/lymphoma 12 52 58
Leukemia-Lymphoma, Adult T-Cell 6 43
Atll 52 58
Adult T-Cell Leukaemia/lymphoma 52
T Cell Leukemia Lymphoma Adult 54
Adult T-Cell Lymphoma/leukemia 71
Adult T-Cell Leukaemia 52
Adult T-Cell Lymphoma 52
Leukemia, T-Cell 71

Characteristics:

Orphanet epidemiological data:

58
adult t-cell leukemia/lymphoma
Inheritance: Multigenic/multifactorial,Not applicable; Age of onset: Adult;

Classifications:

Orphanet: 58  
Rare skin diseases
Rare haematological diseases


External Ids:

Disease Ontology 12 DOID:0050523
KEGG 36 H00009
MeSH 43 D015459
NCIt 49 C3184
SNOMED-CT 67 110007008 77430005
ICD10 32 C91.5
MESH via Orphanet 44 D015459
ICD10 via Orphanet 33 C91.5
UMLS via Orphanet 72 C0023493
Orphanet 58 ORPHA86875
UMLS 71 C0023492 C0023493

Summaries for Adult T-Cell Leukemia

KEGG : 36 Adult T-cell leukemia (ATL) is one of the most aggressive hematologic malignancies and is caused by human T-cell leukemia virus type 1 (HTLV-1). The HTLV-1 Tax protein has been demonstrated to be the oncogenic protein of the virus. Tax may contribute to the process of carcinogenesis by a variety of mechanisms, including upregulating the expression of cellular genes involved in T cell growth and proliferation, including IL-2, IL-2R-alpha, and IL-15. However, ATL cells do not always need Tax expression in the later stage of leukemogenesis. Genetic and epigenetic changes should be implicated in such multistep leukemogenesis. Regarding genetic changes, mutation of p53, and deletion of p16 have been reported in ATL. Mutations of Fas gene are also reported in patients with ATL cells. However, such genetic changes were not frequently detected. In this regard, epigenetic change of p16/INK4A gene was more frequent in ATL cells, and accumulated according to the disease progression. This finding suggests that epigenetic change, including DNA methylation, plays an important role in the leukemogenesis of ATL.

MalaCards based summary : Adult T-Cell Leukemia, also known as adult t-cell leukemia/lymphoma, is related to tropical spastic paraparesis and lymphoma. An important gene associated with Adult T-Cell Leukemia is PMAIP1 (Phorbol-12-Myristate-13-Acetate-Induced Protein 1), and among its related pathways/superpathways are Human T-cell leukemia virus 1 infection and Viral carcinogenesis. The drugs Zidovudine and Peginterferon alfa-2b have been mentioned in the context of this disorder. Affiliated tissues include t cells, bone and skin, and related phenotypes are endocrine/exocrine gland and hematopoietic system

Disease Ontology : 12 A T-cell leukemia that results in abnormal increase of lymphocytes, derives from T-cells, has material basis in Human T-lymphotropic virus 1, which is transmitted by sexual contact, transmitted by contaminated needles used by intravenous-drug users, and transmitted by breast feeding. The infection results in formation of skin lesions.

NIH Rare Diseases : 52 Adult T-cell leukemia/lymphoma (ATL) is is a rare and aggressive T-cell lymphoma that is linked to infection by the human T-cell lymphotropic virus 1 (HTLV-1) . The exact mechanism by which HTLV-I infection causes the ATL is unknown. The clinical features of ATL include generalized swelling of the lymph nodes (lymphadenopathy ), increased liver and spleen size (hepatosplenomegaly ), immunosuppression, high levels of calcium in the blood, lytic bone lesions (spots that appear as "holes" on a standard bone x-ray ), and skin lesions. There are four basic clinical variants of ATL: acute (60% of cases), lymphomatous (20 % of cases), chronic (10% of cases) and smoldering (10% of cases). The best treatment for these patients is unclear and patients should be enrolled in clinical trials whenever possible. Medication may include CHOP chemotherapy (cyclophosphamide, doxorubicin, vincristine and prednisone ) or EPOCH (etoposide, vincristine, doxorubicin, cyclophosphamide and prednisone). In some patients, a bone marrow transplant may be recommended.

Wikipedia : 74 Adult T-cell leukemia/lymphoma (ATL or ATLL) is a rare cancer of the immune system's T-cells caused by... more...

Related Diseases for Adult T-Cell Leukemia

Diseases in the Adult T-Cell Leukemia family:

Human T-Cell Leukemia Virus Type 1 Human T-Cell Leukemia Virus Type 2
Human T-Cell Leukemia Virus Type 3 Leukemia, T-Cell, Chronic

Diseases related to Adult T-Cell Leukemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 581)
# Related Disease Score Top Affiliating Genes
1 tropical spastic paraparesis 33.3 IL2RA IL2 FOXP3 CNTN2
2 lymphoma 31.6 TP53 TNFRSF8 IL2RA IL2 CCR6 BCL11B
3 t-cell adult acute lymphocytic leukemia 31.1 TP53 TNFRSF8 PTHLH IL2 FOXP3 CNTN2
4 prolymphocytic leukemia 31.0 TP53 IL2RA CD7
5 marek disease 31.0 TP53 TNFRSF8
6 hairy cell leukemia 30.9 TP53 IL2RA IL2 IFNA1
7 t-cell acute lymphoblastic leukemia 30.9 TP53 IL2RA IL2 BCL11B
8 thyroiditis 30.8 IL2 IFNA1 FOXP3
9 cutaneous t cell lymphoma 30.8 TNFRSF8 IL2RA IL2 IFNA1 CCR6 CCR4
10 primary cutaneous t-cell lymphoma 30.7 TNFRSF8 IL2RA
11 lymphoma, hodgkin, classic 30.7 TNFRSF8 IL2RA IL2 CCR6 CCR4
12 red cell aplasia 30.7 IL2RA IL2 IFNA1
13 anaplastic large cell lymphoma 30.7 TNFRSF8 IL2RA CD4 CCR4
14 pure red-cell aplasia 30.6 IL2RA IL2 IFNA1
15 peripheral t-cell lymphoma 30.6 TP53 TNFRSF8 IL2 FOXP3 CD4 CCR4
16 lymphopenia 30.6 IL2RA IL2 FOXP3 CCR6 BCL11B
17 mycosis fungoides 30.6 TNFRSF8 IL2RA IL2 IFNA1 FOXP3 CD7
18 mumps 30.5 IL2RA IL2 IFNA1
19 t-cell lymphoblastic leukemia/lymphoma 30.5 TXN TNFRSF8 PTHLH IL2RA IL2 FOXP3
20 lethal midline granuloma 30.4 TNFRSF8 CD7
21 thymoma 30.4 TP53 IL2 IFNA1 FOXP3
22 follicular mucinosis 30.3 TNFRSF8 CD7 CD4
23 pancytopenia 30.3 TP53 IL2RA FOXP3 CD7 CD4
24 exanthem 30.2 IL2 IFNA1 CD4 CCR6
25 autoimmune disease 30.2 IL2RA IL2 IFNA1 FOXP3 CCR6 CCR4
26 severe combined immunodeficiency 30.1 IL2RA IL2 CD7 CD4 CCR6 BCL11B
27 lymphoblastic lymphoma 30.1 TP53 TNFRSF8 CD7 CD4
28 chronic graft versus host disease 30.1 IL2RA CD4
29 intermediate uveitis 30.0 IL2RA IL2 CCR6 CCR4
30 central nervous system lymphoma 30.0 TP53 IL2 CCR6
31 scabies 30.0 TNFRSF8 CD4 CCR6
32 hypersplenism 29.8 IL2RA FOXP3 CD4
33 chickenpox 29.8 IL2 IFNA1 CD4 CCR6
34 pfeiffer syndrome 29.7 TNFRSF8 IL2 CD4 CCR6
35 lymphadenitis 29.7 IL2RA CD4 CCR6
36 stomatitis 29.7 IL2 IFNA1 CD4
37 aplastic anemia 29.6 TP53 IL2RA IL2 IFNA1 FOXP3 CD4
38 acquired immunodeficiency syndrome 29.6 TP53 IL2RA IL2 IFNA1 CD4 CCR6
39 leukemia, acute lymphoblastic 29.4 TP53 PTHLH IL2 CD7 CD4 CCR6
40 herpes zoster 29.4 IL2 IFNA1 CD4 CCR6
41 lymphoma, non-hodgkin, familial 29.4 TP53 TNFRSF8 PMAIP1 IL2RA IL2 CD7
42 sarcoidosis 1 29.4 IL2RA IL2 CD4 CCR6
43 allergic hypersensitivity disease 29.4 IL2 FOXP3 CD4 CCR6
44 leukemia, chronic lymphocytic 29.3 TXN TP53 TNFRSF8 PMAIP1 IL2RA IL2
45 thrombocytopenia due to platelet alloimmunization 29.3 FOXP3 CD4 CCR6
46 listeriosis 29.3 IL2 CD4 CCR6
47 viral infectious disease 29.3 IL2RA IL2 IFNA1 CD4 CCR6
48 progressive multifocal leukoencephalopathy 29.3 IL2 CD4 CCR6
49 peripheral nervous system disease 29.2 TP53 IL2 CD4 CCR6
50 epidermodysplasia verruciformis 1 29.2 TP53 CD4 CCR6

Graphical network of the top 20 diseases related to Adult T-Cell Leukemia:



Diseases related to Adult T-Cell Leukemia

Symptoms & Phenotypes for Adult T-Cell Leukemia

MGI Mouse Phenotypes related to Adult T-Cell Leukemia:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 9.9 BCL11B CADM1 CD4 CD7 FOXP3 IL2
2 hematopoietic system MP:0005397 9.83 BCL11B CADM1 CCR4 CCR6 CD4 CD7
3 immune system MP:0005387 9.5 BCL11B CADM1 CCR4 CCR6 CD4 CD7

Drugs & Therapeutics for Adult T-Cell Leukemia

Drugs for Adult T-Cell Leukemia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 319)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Zidovudine Approved Phase 4 30516-87-1 35370
2
Peginterferon alfa-2b Approved Phase 4 99210-65-8, 215647-85-1
3
Valproic acid Approved, Investigational Phase 4 99-66-1 3121
4 Interferon alpha-2 Phase 4
5 Interferon-alpha Phase 4
6 interferons Phase 4
7 Reverse Transcriptase Inhibitors Phase 4
8 Anticonvulsants Phase 4
9
Vindesine Approved, Investigational Phase 3 59917-39-4, 53643-48-4 40839
10 Orange Approved Phase 3
11
Cefepime Approved, Investigational Phase 3 88040-23-7 5479537
12
Ketamine Approved, Vet_approved Phase 3 6740-88-1 3821
13
Mitoxantrone Approved, Investigational Phase 3 65271-80-9 4212
14
Thioguanine Approved Phase 3 154-42-7 2723601
15
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 3 1177-87-3
16
Dexamethasone Approved, Investigational, Vet_approved Phase 3 50-02-2 5743
17
Methylprednisolone Approved, Vet_approved Phase 3 83-43-2 6741
18
Methylprednisolone hemisuccinate Approved Phase 3 2921-57-5
19
Prednisolone phosphate Approved, Vet_approved Phase 3 302-25-0
20 Prednisolone acetate Approved, Vet_approved Phase 3 52-21-1
21
Cyclophosphamide Approved, Investigational Phase 3 50-18-0, 6055-19-2 2907
22
Carboplatin Approved Phase 2, Phase 3 41575-94-4 10339178 38904 498142
23
Prednisolone Approved, Vet_approved Phase 3 50-24-8 5755
24
Iron Approved, Experimental Phase 3 15438-31-0, 7439-89-6 27284 23925
25
Dalteparin Approved Phase 3 9005-49-6
26
Tinzaparin Approved Phase 3 9041-08-1, 9005-49-6 25244225
27
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 3 437-38-7 3345
28
Levofloxacin Approved, Investigational Phase 3 100986-85-4 149096
29
Ofloxacin Approved Phase 3 82419-36-1 4583
30
Thiotepa Approved, Investigational Phase 2, Phase 3 52-24-4 5453
31
Dextromethorphan Approved Phase 3 125-71-3 5360696 5362449
32
Levoleucovorin Approved, Investigational Phase 3 68538-85-2
33
Amphotericin B Approved, Investigational Phase 3 1397-89-3 5280965 14956
34
Caspofungin Approved Phase 3 162808-62-0, 179463-17-3 2826718 468682
35
Darbepoetin alfa Approved, Investigational Phase 3 11096-26-7, 209810-58-2
36
Tazobactam Approved Phase 3 89786-04-9 123630
37
Vancomycin Approved Phase 3 1404-90-6 14969 441141
38
Piperacillin Approved Phase 3 66258-76-2 43672
39
Hydrocortisone Approved, Vet_approved Phase 3 50-23-7 5754
40
Hydrocortisone acetate Approved, Vet_approved Phase 3 50-03-3
41
Cytarabine Approved, Experimental, Investigational Phase 3 147-94-4, 65-46-3 6253
42
Daunorubicin Approved Phase 3 20830-81-3 30323
43
leucovorin Approved Phase 3 58-05-9 6006 143
44
Methotrexate Approved Phase 3 59-05-2, 1959-05-2 126941
45
rituximab Approved Phase 3 174722-31-7 10201696
46
Melphalan Approved Phase 3 148-82-3 460612 4053
47
Mercaptopurine Approved Phase 3 50-44-2 667490
48
Idarubicin Approved Phase 2, Phase 3 58957-92-9 42890
49
Pegaspargase Approved, Investigational Phase 3 130167-69-0
50
Vincristine Approved, Investigational Phase 2, Phase 3 57-22-7, 2068-78-2 5978

Interventional clinical trials:

(show top 50) (show all 362)
# Name Status NCT ID Phase Drugs
1 HTLV-I Associated Adult T-cell Leukaemia/Lymphoma (ATLL) Pilot Study of Combination Therapy With CHOP-Zenapax (CHOP-daclizumab) Completed NCT01418430 Phase 4 CHOP-daclizumab
2 HTLV Blot 2.4 Post-Market Clinical Study of Neurological Disorders and HTLV Positive Specimens Completed NCT03226119 Phase 4
3 Prospective Study of the Molecular Characteristics of Sensitive and Resistant Disease in Patients With HTLV-I Associated Adult T Cell Leukemia Treated With Zidovudine (AZT) Plus Interferon Alpha-2b Terminated NCT00854581 Phase 4 Valproic Acid;Zidovudine
4 A Prospective Randomised Phase III Trial of Early Hospital Discharge Versus Standard Inpatient Management of Cancer Patients With Low-Risk Febrile Neutropenia Receiving Oral Antibiotics. Oral Antibiotics for Neutropenic Sepsis Giving Early Hospital Discharge [ORANGE] Unknown status NCT00445497 Phase 3 amoxicillin-clavulanate potassium;ciprofloxacin
5 Multicenter, Double-Blind, Randomized Study to Compare the Safety and Efficacy of Levofloxacin With That of Cefepime in the Treatment of Fever and Neutropenia - Phase IIIB Unknown status NCT00020865 Phase 3 cefepime hydrochloride;levofloxacin
6 A Randomized Double-Blind Controlled Trial of Ketamine Versus Placebo in Conjunction With Best Pain Management in Neuropathic Pain in Cancer Patients Unknown status NCT01316744 Phase 3 ketamine hydrochloride
7 Randomised Study Comparing 6 And 8 Cycles Of Chemotherapy With CHOP ( Cyclophosphamide, Doxorubicin, Vincristine And Prednisone) At 14-Day Intervals (CHOP-14), Both With Or Without The Monoclonal Anti-CD20 Antibody Rituximab In Patients Aged 61 To 80 Years With Aggressive Non-Hodgkin's Lymphoma Unknown status NCT00052936 Phase 3 CHOP regimen;cyclophosphamide;doxorubicin hydrochloride;prednisone;vincristine sulfate
8 Compared the Efficacy and Safety of CDOP Combined With Chidamide and CDOP in de Novo Peripheral T Cell Lymphoma Patients Unknown status NCT03023358 Phase 3 chidamide;cyclophosphamide;liposomal doxorubicin;vincristine;prednisone
9 The Value of Dexamethasone Versus Prednisolone During Induction and Maintenance Therapy of Prolonged Versus Conventional Duration of L-Asparaginase Therapy During Consolidation and Late Intensification, and of Corticosteroid + VCR Pulses During Maintenance in Acute Lymphoblastic Leukemia and Lymphoblastic Non-Hodgkin Lymphoma of Childhood Unknown status NCT00003728 Phase 3 asparaginase;cyclophosphamide;cytarabine;daunorubicin hydrochloride;dexamethasone;doxorubicin hydrochloride;etoposide;leucovorin calcium;mercaptopurine;methotrexate;methylprednisolone;mitoxantrone hydrochloride;prednisolone;therapeutic hydrocortisone;thioguanine;vincristine sulfate;vindesine
10 Phase III Study of VCAP-AMP-VECP vs. Biweekly CHOP in Aggressive Adult T-cell Leukemia-lymphoma (ATLL): Japan Clinical Oncology Group Study, JCOG9801. Completed NCT00145002 Phase 3 VCAP-AMP-VECP with G-CSF and intrathecal prophylaxis;biweekly-CHOP with G-CSF and intrathecal prophylaxis
11 A Phase III Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Effects of Fragmin (5,000 IU Subcutaneously) in Preventing Catheter-Related Complications When Given Daily to Cancer Patients With Central Venous Catheters Completed NCT00006083 Phase 3 Fragmin
12 A Phase III Double-Blind Equivalence Study of Two Different Formulations of Slow-Release Morphine Followed by a Randomization Between Dextromethorphan or Placebo Plus Statex SR for Chronic Cancer Pain Relief in Terminally Ill Patients Completed NCT00003687 Phase 3 dextromethorphan hydrobromide;morphine sulfate
13 Preparatory Aid to Improve Decision Making About Cancer Clinical Trials (PRE-ACT) Completed NCT00750009 Phase 3
14 A Strategic Study to Determine the Optimal Moment to Initiate Systemic Antifungal Therapy With Ambisome in Granulocytopenic Cancer Patients With Unexplained Fever Refractory to Empirical Antibacterials Completed NCT00003938 Phase 3 liposomal amphotericin B
15 A Multicenter, Double-Blind, Randomized, Comparative Study To Evaluate The Safety, Tolerability, And Efficacy Of MK-0991 Versus (Amphotericin B) Liposome For Injection As Empirical Therapy In Patients With Persistent Fever And Neutropenia Completed NCT00008359 Phase 3 caspofungin acetate;liposomal amphotericin B
16 The Use of American Ginseng (Panax Quinquefolius) to Improve Cancer-Related Fatigue: A Randomized, Double-Blind, Placebo-Controlled Phase III Study Completed NCT00719563 Phase 3 American ginseng
17 Phase III Randomized Trial of an Opioid Titration Order Sheet Compared to Standard of Care in Patients With Cancer Related Pain. Completed NCT00666211 Phase 3
18 Phase III, Randomized, Double-Blind, Placebo-Controlled Crossover Trial of Ondansetron in the Control of Chronic Nausea and Vomiting Not Due to Antineoplastic Therapy in Patients With Advanced Cancer Completed NCT00006348 Phase 3 ondansetron
19 A Randomized, Prospective Double-Blind, Placebo-Controlled Trial of Prophylactic Oral Levofloxacin Following Chemotherapy for Lymphoma and Solid Tumors Completed NCT00005590 Phase 3 levofloxacin
20 A Randomized, Open-Label, Multicenter Study Of Darbepoetin Alfa Administered Once Every Two Weeks (Q2W) Compared With rHuEPO Administered Once Every Week (QW) For The Treatment Of Anemia In Subjects With Non-Myeloid Malignancies Receiving Multiple Chemotherapy Completed NCT00070382 Phase 3 darbepoetin alfa;epoetin alfa
21 Does Hypericum Reduce Fatigue in Cancer Patients on Chemotherapy? A Randomized, Double-Blind, Placebo-Controlled Clinical Trial Completed NCT00005805 Phase 3
22 Vancomycin Versus Placebo in Persistently Febrile Granulocytopenic Patients Given Piperacillin/Tazobactam Completed NCT00003805 Phase 3 piperacillin sodium;piperacillin-tazobactam;tazobactam sodium;vancomycin
23 A Phase III, Randomized Study of the Effects of Parenteral Iron, Oral Iron, or No Iron Supplementation on the Erythropoietic Response to Darbepoetin Alfa for Cancer Patients With Chemotherapy-Associated Anemia Completed NCT00661999 Phase 3 sodium ferric gluconate complex in sucrose
24 A Randomized, Double-blind, Placebo-controlled Multi-center Study to Evaluate the Safety and Efficacy of Fentanyl Sublingual Spray (Fentanyl SL Spray) for the Treatment of Breakthrough Cancer Pain Completed NCT00538850 Phase 3 Fentanyl sublingual spray;Placebo
25 Allogeneic Blood or Marrow Transplantation for Hematologic Malignancy and Aplastic Anemia Completed NCT00003816 Phase 2, Phase 3 busulfan;carboplatin;cyclophosphamide;etoposide;fludarabine phosphate;melphalan;thiotepa
26 Intensive Treatment For T-CELL Acute Lymphoblastic Leukemia and Advanced Stage Lymphoblastic Non-Hodgkin's Lymphoma: A Pediatric Oncology Group Phase III Study Completed NCT01230983 Phase 3 asparaginase;cytarabine;dexrazoxane hydrochloride;doxorubicin hydrochloride;leucovorin calcium;mercaptopurine;methotrexate;prednisone;therapeutic hydrocortisone;vincristine sulfate
27 ALLR3: An International Collaborative Trial for Relapsed and Refractory Acute Lymphoblastic Leukaemia (ALL) Completed NCT00967057 Phase 3 asparaginase;dexamethasone;idarubicin;methotrexate;mitoxantrone hydrochloride;pegaspargase;vincristine sulfate
28 A Multicenter Study of Treatment Protocol for Childhood Acute Lymphoblastic Leukemia in China, 2008. Completed NCT00707083 Phase 3 dexamethasone;mercaptopurine;methotrexate;vincristine sulfate
29 Treatment of Acute Lymphoblastic Leukemia in Children Completed NCT00400946 Phase 3 asparaginase;cyclophosphamide;cytarabine;dexamethasone;dexrazoxane hydrochloride;doxorubicin hydrochloride;etoposide;leucovorin calcium;mercaptopurine;methotrexate;methylprednisolone;pegaspargase;prednisolone;therapeutic hydrocortisone;vincristine sulfate
30 An Open-Label, One-Arm, Multi-Site Trial of Precision Diagnosis Directing Histone Deacetylase Inhibitor Chidamide Total Therapy for Adult T-lymphoblastic Lymphoma/Leukemia Recruiting NCT03564704 Phase 2, Phase 3 Dexamethasone;vincristine;Cyclophosphamide;Idarubicin;Pegaspargase;Adriamycin;Methotrexate;6-mercaptopurine.;Etoposide;Cytarabine;Chidamide
31 An Open-Label, One-Arm, Multi-Site Trial of Precision Diagnosis Directing Histone Deacetylase Inhibitor Chidamide Target Total Therapy for Adult Early T-cell Progenitor Acute Lymphoblastic Leukemia/Lymphoma Recruiting NCT03553238 Phase 2, Phase 3 Chidamide;Dexamethasone;vincristine;Cyclophosphamide;Idarubicin;Pegaspargase;Adriamycin;Methotrexate;6-Mercaptopurine;Etoposide;Cytarabine
32 A Randomized Trial for Adults With Newly Diagnosed Acute Lymphoblastic Leukemia Recruiting NCT01085617 Phase 3 cyclophosphamide;cytarabine;daunorubicin hydrochloride;etoposide;fludarabine phosphate;imatinib mesylate;melphalan;mercaptopurine;methotrexate;nelarabine;pegaspargase;vincristine sulfate
33 Diffuse Large B Cell And Peripheral T Cell Non-Hodgkin's Lymphomas (NHL) In The Elderly. Influence Of Prolonged Oral Etoposide Added To CHOP Combination Chemotherapy In Patients With Good Physiological Status. An EORTC Randomized Phase II-III Trial Including Geriatric Assessment And Quality Of Life Terminated NCT00060385 Phase 2, Phase 3 CHOP regimen;EPOCH regimen;cyclophosphamide;doxorubicin hydrochloride;etoposide;prednisone;vincristine sulfate
34 A Phase II Evaluation of High Dose Chemotherapy and Autologous Stem Cell Transplantation for Intestinal T-cell Lymphomas Unknown status NCT00669812 Phase 2 carmustine;cyclophosphamide;cytarabine;doxorubicin hydrochloride;epirubicin hydrochloride;etoposide;ifosfamide;melphalan;methotrexate;prednisolone;vincristine sulfate
35 Alemtuzumab and CHOP Chemotherapy for Aggressive Histology Peripheral T Cell Lymphomas: A Multi-Centre Phase I and II Study Unknown status NCT00363090 Phase 1, Phase 2 cyclophosphamide;doxorubicin hydrochloride;prednisone;vincristine sulfate
36 Non-Ablative Chemotherapeutic Conditioning Before Allogeneic Stem Cell Transplantation Unknown status NCT00008307 Phase 2 cyclosporine;fludarabine phosphate;melphalan;methylprednisolone;mycophenolate mofetil
37 Phase II Study of Arsenic Trioxide in Relapsed/Refractory Acute Leukemia and Blast Crisis of Chronic Myeloid Leukemia Unknown status NCT00003885 Phase 2 arsenic trioxide
38 Allograft of Hematopoietic Stem Cells With Reduced-intensity Conditioning From a HLA-haploidentical Family Donor: Phase II Study of Combined Immunosuppression Before and After Transplantation Unknown status NCT00740467 Phase 2 busulfan;cyclophosphamide;cyclosporine;fludarabine phosphate;mycophenolate mofetil
39 Radiation Therapy in Combination With Indinavir / Ritonavir (Crixivan / Norvir) for the Treatment of Brain Metastases: a Randomized Phase II Study Unknown status NCT00637637 Phase 2 indinavir sulfate;ritonavir
40 DFCI ALL Adult Consortium Protocol: Adult ALL Trial Unknown status NCT01005758 Phase 2 cyclophosphamide;cytarabine;dexamethasone;doxorubicin hydrochloride;etoposide phosphate;hydrocortisone sodium succinate;imatinib mesylate;mercaptopurine;methotrexate;methylprednisolone;pegaspargase;prednisolone;prednisone;vincristine sulfate
41 MULTICENTRE TRIAL OF INTENSIFIED THERAPY FOR ADULT ALL (O5/93) Unknown status NCT00002531 Phase 2 asparaginase;cyclophosphamide;cytarabine;daunorubicin hydrochloride;dexamethasone;doxorubicin hydrochloride;etoposide;ifosfamide;leucovorin calcium;mercaptopurine;methotrexate;mitoxantrone hydrochloride;prednisolone;teniposide;thioguanine;vincristine sulfate;vindesine
42 A Phase 2, Multicenter, Single-arm, Open-label Study to Evaluate the Safety and Efficacy of Lenalidomide in Patients With Relapsed or Recurrent Adult T-cell Leukemia-lymphoma Completed NCT01724177 Phase 2 Lenalidomide
43 Phase II Clinical Study of KW-0761 in Patients With CCR4-Positive Adult T-cell Leukemia-Lymphoma Completed NCT00920790 Phase 2
44 A Phase II Study of Lenalidomide in Patients With Relapsed or Refractory HTLV-1 Associated Adult T Cell Leukemia/Lymphoma Completed NCT01274533 Phase 2 Lenalidomide
45 Phase II Trial of Nivolumab for HTLV-Associated Adult T Cell Leukemia/Lymphoma Completed NCT02631746 Phase 2
46 Multi-Center, Open-Label, Randomized Study of Anti-CCR4 Monoclonal Antibody KW-0761 or Investigator's Choice in Subjects With Previously Treated Adult T-cell Leukemia-Lymphoma (ATL) Completed NCT01626664 Phase 2 Pralatrexate;gemcitabine plus oxaliplatin;DHAP
47 Multicenter, Randomized, Open-label, Parallel-group Study to Compare mLSG15 + KW-0761 to mLSG15 in Subjects With CCR4-positive Adult T-cell Leukemia-lymphoma (Untreated Primary Disease) Completed NCT01173887 Phase 2 VCAP/AMP/VECP(mLSG15)
48 Phase II Trial Of Induction Therapy With EPOCH Chemotherapy And Maintenance Therapy With Combivir/Interferon ALPHA-2a For HTLV-1 Associated T-Cell Non-Hodgkin's Lymphoma Completed NCT00041327 Phase 2 Etoposide;cyclophosphamide;doxorubicin hydrochloride;lamivudine;prednisone;vincristine sulfate;zidovudine
49 Phase II Study of Therapy With IMTOX-25 in Adults With Refractory/Relapsed Cd25 Positive Adult T Cell Leukemia/Lymphoma Completed NCT01378871 Phase 2 IMTOX-25
50 Phase II Study of the Efficacy and Toxicity of Campath-1H in the Therapy of Adult T-Cell Leukemia Completed NCT00061048 Phase 2

Search NIH Clinical Center for Adult T-Cell Leukemia

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Adult T-Cell Leukemia cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Adult T-Cell Leukemia:
Hematopoietic stem cells for treatment of hematologic malignancies
Embryonic/Adult Cultured Cells Related to Adult T-Cell Leukemia:
Bone marrow-derived hematopoietic stem cells

Cochrane evidence based reviews: leukemia-lymphoma, adult t-cell

Genetic Tests for Adult T-Cell Leukemia

Anatomical Context for Adult T-Cell Leukemia

MalaCards organs/tissues related to Adult T-Cell Leukemia:

40
T Cells, Bone, Skin, Bone Marrow, B Cells, Liver, Breast

Publications for Adult T-Cell Leukemia

Articles related to Adult T-Cell Leukemia:

(show top 50) (show all 4670)
# Title Authors PMID Year
1
Production and characterization of an active single-chain variable fragment antibody recognizing CD25. 54 61
15978327 2005
2
Activation of interleukin-2 receptor alpha expression by extracellular HTLV-I Tax1 protein: a potential role in HTLV-I pathogenesis. 61 54
1501887 1992
3
Hypercalcemia and production of parathyroid hormone-like protein in adult T-cell leukemia-lymphoma. 61 54
1644163 1992
4
Rearrangement of human T cell receptor beta and gamma chain genes in adult T cell leukemia/lymphoma. 61 54
2160910 1990
5
High-yield production in E. coli and characterization of full-length functional p13II protein from human T-cell leukemia virus type 1. 61
32360379 2020
6
Molecular targeting of PD-1 signaling pathway as a novel therapeutic approach in HTLV-1 infection. 61
32283259 2020
7
Improved survival for skin-primary presentation of adult T-cell leukemia/lymphoma (ATLL). 61
31765683 2020
8
Efficacy and Safety of the Modified EPOCH Regimen (Etoposide, Vincristine, Doxorubicin, Carboplatin, and Prednisolone) for Adult T-cell Leukemia/Lymphoma: A Multicenter Retrospective Study. 61
32312633 2020
9
Human T cell lymphotropic virus type-1 associated lymphoma presenting as an intramuscular mass of the calf. 61
32076761 2020
10
Immunophenotypic analysis of cerebrospinal fluid reveals concurrent development of ATL in the CNS of a HAM/TSP patient. 61
31930455 2020
11
Thymoquinone synergizes with arsenic and interferon alpha to target human T-cell leukemia/lymphoma. 61
32272181 2020
12
Phylogenetic and phylodynamic study of Human T-cell lymphotropic virus Type 1 (HTLV-1) in Iran. 61
32561293 2020
13
Frequent horizontal and mother-to-child transmission may contribute to high prevalence of STLV-1 infection in Japanese macaques. 61
32576215 2020
14
Erythroderma: a prospective study of 309 patients followed for 12 years in a tertiary center. 61
32555205 2020
15
HTLV-1 seropositive patients with lung cancer treated with PD-1 inhibitors. 61
32557883 2020
16
Clinicopathological analysis of immunohistochemical expression of CD47 and SIRPα in adult T-cell leukemia/lymphoma. 61
32569413 2020
17
MALT-1 as a novel therapeutic target for adult T-cell leukemia. 61
32574386 2020
18
CD4-/CD8+ adult T-cell leukemia/lymphoma with unusual morphology presenting as ascites and pleural effusion. 61
31820571 2020
19
Evolution of retrovirus-infected premalignant T-cell clones prior to adult T-cell leukemia/lymphoma diagnosis. 61
32160278 2020
20
Successful treatment with brentuximab vedotin for relapsed and refractory adult T cell leukemia. 61
31934889 2020
21
Clinical efficacy of mogamulizumab for relapsed/refractory aggressive adult T-cell leukemia/lymphoma: A retrospective analysis. 61
32564395 2020
22
Predicting the future: adult T-cell leukemia. 61
32497221 2020
23
Targeted deep sequencing reveals clonal and subclonal mutational signatures in Adult T-cell leukemia/lymphoma and defines an unfavorable indolent subtype. 61
32555298 2020
24
Lymphomatous Adult T-cell Leukemia/Lymphoma with Anaplastic Morphology in a Country non-Endemic for HTLV: A Mimicker of Anaplastic Large Cell Lymphoma. 61
32516451 2020
25
Lymphomatous Adult T-cell Leukemia/Lymphoma with Anaplastic Morphology in a Country non-Endemic for HTLV: A Mimicker of Anaplastic Large Cell Lymphoma. 61
32510673 2020
26
Corrigendum to "Development of a complete human IgG monoclonal antibody to transferrin receptor 1 targeted for adult T-cell leukemia/lymphomaˮ [Biochem. Biophys. Res. Commun. 485 (1) 2017 144-151]. 61
32553628 2020
27
Defining signatures of peripheral T-cell lymphoma with a targeted 20-marker gene expression profiling assay. 61
31488561 2020
28
The effect of alcoholic extract from Eucalyptus camaldulensis leaves on HTLV-1 Tax activities. 61
32564665 2020
29
A Suggested Immunohistochemical Algorithm for the Classification of T Cell Lymphomas Involving Lymph Node. 61
32479842 2020
30
Comprehensive immunohistochemical analysis of immune checkpoint molecules in adult T cell leukemia/lymphoma. 61
32157421 2020
31
Mortality and risk of progression to adult T cell leukemia/lymphoma in HTLV-1-associated myelopathy/tropical spastic paraparesis. 61
32393644 2020
32
Mantle cell lymphoma mimicking adult T-cell leukemia. 61
32019688 2020
33
Indolent multipapular adult T-cell leukemia/lymphoma with phenotype of resident memory T cells. 61
32383209 2020
34
RNF8 Dysregulation and Down-regulation During HTLV-1 Infection Promote Genomic Instability in Adult T-Cell Leukemia. 61
32453758 2020
35
Apoptosis as a mechanism for the treatment of adult T cell leukemia: promising drugs from benchside to bedside. 61
32389641 2020
36
Orbital and Ocular Adnexal Manifestations of Adult T-Cell Leukemia/Lymphoma: a Case Report and Systematic Review. 61
32427727 2020
37
Adult T-cell leukemia/lymphoma incidence rate in French Guiana: a prospective cohort of women infected with HTLV-1. 61
32396612 2020
38
Adult T-cell leukemia/lymphoma and Glucose-6-phosphate dehydrogenase deficiency rapidly diagnosed through blood smear examination. 61
32429624 2020
39
Robust CD8+ T-cell proliferation and diversification after mogamulizumab in patients with adult T-cell leukemia-lymphoma. 61
32433748 2020
40
Inefficient Tax-Specific T-Cell Responses in Mice after Syngeneic Transplantation with tax-Transgenic Mouse-Derived Adult T-Cell Leukemia Cells. 61
32009059 2020
41
cDNA-Based Mutation Screening Using a Combination of High-Resolution Melting Curve and Fragment Analysis Facilitates Efficient CCR4 Mutation Analysis in Adult T-Cell Leukemia/Lymphoma. 61
32367127 2020
42
Correction to: Treatment of aggressive adult T-cell leukemia/lymphoma: a retrospective study in a hospital located in HTLV-1 highly endemic area. 61
32144642 2020
43
Clinical Outcomes of Patients with Adult T Cell Leukemia-Lymphoma in a Nonendemic Metropolitan Area: A Retrospective Analysis of the Population-Based Osaka Cancer Registry. 61
32417489 2020
44
Antiretroviral Therapy in HTLV-1 Infection: An Updated Overview. 61
32369988 2020
45
Clinical features and human T-cell leukemia virus type-1 (HTLV-1) proviral load in HTLV-1-positive patients with rheumatoid arthritis: Baseline data in a single center cohort study. 61
30938551 2020
46
Synthetic (E)-3-Phenyl-5-(phenylamino)-2-styryl-1,3,4-thiadiazol-3-ium Chloride Derivatives as Promising Chemotherapy Agents on Cell Lines Infected with HTLV-1. 61
32486038 2020
47
Activation of PERK-ATF4-CHOP pathway as a novel therapeutic approach for efficient elimination of HTLV-1-infected cells. 61
32369565 2020
48
Targeting aberrant DNA hypermethylation as a driver of ATL leukemogenesis using the new oral demethylating agent OR-2100. 61
32391874 2020
49
Complete genome sequence of human T-cell lymphotropic type 1 from patients with different clinical profiles, including infective dermatitis. 61
31883457 2020
50
Granuloma With an Underlying Lymphoma: A Diagnostic Challenge and a Wider Histologic Spectrum Including Adult T-Cell Leukemia/Lymphoma. 61
30653030 2020

Variations for Adult T-Cell Leukemia

ClinVar genetic disease variations for Adult T-Cell Leukemia:

6 ‎‎ ‎‎ ‎‎
# Gene Name Type Significance ClinVarId dbSNP ID GRCh37 Pos GRCh38 Pos
1 NT5C2 NM_012229.4(NT5C2):c.1100G>A (p.Arg367Gln)SNV not provided 376349 rs1057519866 10:104852955-104852955 10:103093198-103093198
2 NT5C2 NM_012229.4(NT5C2):c.1075A>C (p.Lys359Gln)SNV not provided 376350 rs1057519867 10:104852980-104852980 10:103093223-103093223
3 NT5C2 NM_012229.4(NT5C2):c.1220A>C (p.Asp407Ala)SNV not provided 376351 rs1057519868 10:104850745-104850745 10:103090988-103090988

Expression for Adult T-Cell Leukemia

Search GEO for disease gene expression data for Adult T-Cell Leukemia.

Pathways for Adult T-Cell Leukemia

Pathways related to Adult T-Cell Leukemia according to KEGG:

36
# Name Kegg Source Accession
1 Human T-cell leukemia virus 1 infection hsa05166
2 Viral carcinogenesis hsa05203

Pathways related to Adult T-Cell Leukemia according to GeneCards Suite gene sharing:

(show all 14)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.6 TP53 TNFRSF8 SPOCK3 PMAIP1 IL2RA IL2
2
Show member pathways
13.22 TP53 TNFRSF8 IL2RA IL2 CD4 CCR6
3 12.63 TP53 PMAIP1 IL2RA IL2 IFNA1
4
Show member pathways
12.63 IL2RA IL2 IFNA1 FOXP3 CD4
5 12.07 TP53 IL2RA IL2 CD4
6
Show member pathways
12.04 IL2RA IL2 CCR6 CCR4
7 11.74 TXN TNFRSF8 PDLIM2 IL2RA IL2 IFNA1
8 11.71 IL2RA CD7 CD4
9
Show member pathways
11.51 IL2RA IL2 FOXP3
10
Show member pathways
11.37 IL2RA IL2 FOXP3
11 11.26 IL2RA IL2 CD7 CD4 CCR6
12 11.12 IL2RA IL2 FOXP3 CD4
13
Show member pathways
11.05 IL2RA IL2 FOXP3
14 10.88 IL2RA IL2 CD4

GO Terms for Adult T-Cell Leukemia

Biological processes related to Adult T-Cell Leukemia according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of cell proliferation GO:0008285 9.88 TP53 TNFRSF8 PTHLH FOXP3 BCL11B
2 cytokine-mediated signaling pathway GO:0019221 9.77 TP53 IL2RA IL2 IFNA1 CD4
3 immune response GO:0006955 9.73 IL2RA IL2 CD7 CD4 CCR6 CCR4
4 positive regulation of T cell proliferation GO:0042102 9.63 IL2RA IL2 CD4
5 T cell activation GO:0042110 9.61 FOXP3 CD7 CD4
6 negative regulation of immune response GO:0050777 9.54 IL2RA FOXP3
7 positive regulation of regulatory T cell differentiation GO:0045591 9.52 IL2 FOXP3
8 interleukin-2-mediated signaling pathway GO:0038110 9.51 IL2RA IL2
9 T cell homeostasis GO:0043029 9.5 PMAIP1 IL2RA FOXP3
10 negative regulation of T-helper 17 cell differentiation GO:2000320 9.49 IL2 FOXP3
11 regulation of T cell homeostatic proliferation GO:0046013 9.4 IL2RA IL2
12 tolerance induction GO:0002507 9.16 FOXP3 CCR4
13 regulation of regulatory T cell differentiation GO:0045589 9.13 IL2RA IL2 FOXP3
14 negative regulation of lymphocyte proliferation GO:0050672 8.8 IL2RA IL2 FOXP3

Molecular functions related to Adult T-Cell Leukemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.58 TXN TP53 TNFRSF8 SPOCK3 PTHLH PRDM16

Sources for Adult T-Cell Leukemia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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