ATLL
MCID: ADL017
MIFTS: 63

Adult T-Cell Leukemia (ATLL)

Categories: Blood diseases, Cancer diseases, Immune diseases, Rare diseases, Skin diseases

Aliases & Classifications for Adult T-Cell Leukemia

MalaCards integrated aliases for Adult T-Cell Leukemia:

Name: Adult T-Cell Leukemia 39 12 38 15
Adult T-Cell Leukemia/lymphoma 12 54 60
Leukemia-Lymphoma, Adult T-Cell 6 45
Atll 54 60
Adult T-Cell Leukaemia/lymphoma 54
T Cell Leukemia Lymphoma Adult 56
Adult T-Cell Lymphoma/leukemia 74
Adult T-Cell Leukaemia 54
Adult T-Cell Lymphoma 54
Leukemia, T-Cell 74

Characteristics:

Orphanet epidemiological data:

60
adult t-cell leukemia/lymphoma
Inheritance: Multigenic/multifactorial,Not applicable; Age of onset: Adult;

Classifications:



External Ids:

Disease Ontology 12 DOID:0050523
KEGG 38 H00009
MeSH 45 D015459
NCIt 51 C3184
SNOMED-CT 69 77430005
ICD10 34 C91.5 C91.50
MESH via Orphanet 46 D015459
ICD10 via Orphanet 35 C91.5
UMLS via Orphanet 75 C0023493
Orphanet 60 ORPHA86875

Summaries for Adult T-Cell Leukemia

NIH Rare Diseases : 54 Adult T-cell leukemia/lymphoma (ATL) is is a rare and aggressive T-cell lymphoma that is linked to infection by the human T-cell lymphotropic virus 1 (HTLV-1). The exact mechanism by which HTLV-I infection causes the ATL is unknown. The clinical features of ATL include generalized swelling of the lymph nodes (lymphadenopathy), increased liver and spleen size (hepatosplenomegaly), immunosuppression, high levels of calcium in the blood, lytic bone lesions (spots that appear as �??holes�?� on a standard bone x-ray), and skin lesions.  There are four basic clinical variants of ATL: acute (60% of cases), lymphomatous (20 % of cases), chronic (10% of cases) and smoldering (10% of cases). The best treatment for these patients is unclear and patients should be enrolled in clinical trials whenever possible. Medication may include CHOP chemotherapy (cyclophosphamide, doxorubicin, vincristine and prednisone) or EPOCH (etoposide, vincristine, doxorubicin, cyclophosphamide and prednisone). In some patients, a bone marrow transplant may be recommended.

MalaCards based summary : Adult T-Cell Leukemia, also known as adult t-cell leukemia/lymphoma, is related to tropical spastic paraparesis and t-cell adult acute lymphocytic leukemia. An important gene associated with Adult T-Cell Leukemia is PMAIP1 (Phorbol-12-Myristate-13-Acetate-Induced Protein 1), and among its related pathways/superpathways are Human T-cell leukemia virus 1 infection and Viral carcinogenesis. The drugs Vincristine and Ifosfamide have been mentioned in the context of this disorder. Affiliated tissues include t cells, bone and bone marrow, and related phenotypes are no effect and hematopoietic system

Disease Ontology : 12 A T-cell leukemia that results in abnormal increase of lymphocytes, derives from T-cells, has material basis in Human T-lymphotropic virus 1, which is transmitted by sexual contact, transmitted by contaminated needles used by intravenous-drug users, and transmitted by breast feeding. The infection results in_formation_of skin lesions.

Wikipedia : 77 Lymphoma is a group of blood cancers that develop from lymphocytes (a type of white blood cell). The... more...

Related Diseases for Adult T-Cell Leukemia

Diseases in the T-Cell Leukemia family:

Adult T-Cell Leukemia Acute T Cell Leukemia
Human T-Cell Leukemia Virus Type 1 Human T-Cell Leukemia Virus Type 2
Human T-Cell Leukemia Virus Type 3 Leukemia, B-Cell, Chronic
Leukemia, T-Cell, Chronic

Diseases related to Adult T-Cell Leukemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 202)
# Related Disease Score Top Affiliating Genes
1 tropical spastic paraparesis 32.6 CNTN2 FOXP3 IL2 IL2RA
2 t-cell adult acute lymphocytic leukemia 31.8 BCL11B CD7 FOXP3 IL2 IRF4 PTHLH
3 t-cell leukemia 31.0 BCL11B CCND2 CD7 CNTN2 IL2 IL2RA
4 cutaneous t cell lymphoma 30.7 CCR4 IL2 IL2RA TNFRSF8
5 peripheral t-cell lymphoma 30.7 CCR4 IL2 TNFRSF8
6 acquired immunodeficiency syndrome 30.6 IL2 IL2RA TP53
7 mycosis fungoides 30.4 CCR4 CD7 IL2 IL2RA TNFRSF8
8 marek disease 30.1 TNFRSF8 TP53
9 lymphopenia 30.1 FOXP3 IL2 IL2RA
10 immunodysregulation, polyendocrinopathy, and enteropathy, x-linked 30.1 FOXP3 IL2 IL2RA
11 leukemia, chronic lymphocytic 30.1 CCND2 IL2 IL2RA TP53
12 b-cell lymphomas 30.0 CCND2 IRF4 TNFRSF8 TP53
13 sezary's disease 29.9 CCR4 CD7 IL2 IL2RA TNFRSF8
14 myeloma, multiple 29.7 CCND2 IL2 IRF4 PMAIP1 TP53
15 diffuse large b-cell lymphoma 29.4 IRF4 TNFRSF8 TP53
16 lymphoma, non-hodgkin, familial 29.1 CCND2 CD7 IL2 IL2RA IRF4 TNFRSF8
17 human t-cell leukemia virus type 1 11.7
18 myelopathy, htlv-1-associated 11.6
19 leukemia 11.5
20 precursor t-cell acute lymphoblastic leukemia 11.4
21 lymphoma 11.3
22 lymphoid leukemia 11.3
23 retrovirus-associated myelopathy 11.3
24 hematopoietic stem cell transplantation 10.6
25 acute t cell leukemia 10.6
26 spastic paraparesis 10.4
27 pneumonia 10.4
28 fixed drug eruption 10.3 CCR4 IL2
29 scabies 10.3
30 anaplastic large cell lymphoma 10.3
31 recurrent respiratory papillomatosis 10.3 IL2 TP53
32 pityriasis lichenoides 10.3 CD7 TNFRSF8
33 pityriasis lichenoides et varioliformis acuta 10.3 CD7 TNFRSF8
34 autoimmune enteropathy 10.2 FOXP3 IL2RA
35 leukemia, acute myeloid 10.2
36 graft-versus-host disease 10.2
37 hepatitis 10.2
38 hepatitis b 10.2
39 dermatitis 10.2
40 acute pancreatitis 10.2
41 pancreatitis 10.2
42 myeloid leukemia 10.2
43 cytomegalovirus infection 10.2
44 immune deficiency disease 10.2 IL2 IL2RA TNFRSF8
45 rheumatoid arthritis 10.2
46 arthritis 10.2
47 bone resorption disease 10.2
48 lymphocytic leukemia 10.2
49 strongyloidiasis 10.2
50 sarcoma 10.2

Graphical network of the top 20 diseases related to Adult T-Cell Leukemia:



Diseases related to Adult T-Cell Leukemia

Symptoms & Phenotypes for Adult T-Cell Leukemia

GenomeRNAi Phenotypes related to Adult T-Cell Leukemia according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 no effect GR00402-S-1 9.92 BCL11B CADM1 CCND2 CCR4 CCR6 CD7

MGI Mouse Phenotypes related to Adult T-Cell Leukemia:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.27 BCL11B CADM1 CCND2 CCR4 CCR6 CD7
2 endocrine/exocrine gland MP:0005379 10.21 BCL11B CADM1 CCND2 CD7 FOXP3 IL2
3 behavior/neurological MP:0005386 10.16 BCL11B CADM1 CCND2 CNTN2 EPC1 FOXP3
4 immune system MP:0005387 10.16 BCL11B CADM1 CCND2 CCR4 CCR6 CD7
5 growth/size/body region MP:0005378 10.14 BCL11B CADM1 EPC1 FOXP3 IL2 IL2RA
6 homeostasis/metabolism MP:0005376 10.1 BCL11B CCND2 CCR6 EPC1 FOXP3 IL2
7 liver/biliary system MP:0005370 9.7 CCND2 FOXP3 IL2 JUND PRDM16 PTHLH
8 respiratory system MP:0005388 9.56 CCR4 FOXP3 IL2 IL2RA JUND PRDM16
9 vision/eye MP:0005391 9.23 BCL11B CCND2 FOXP3 IL2 IL2RA PRDM16

Drugs & Therapeutics for Adult T-Cell Leukemia

Drugs for Adult T-Cell Leukemia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 457)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Vincristine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 2068-78-2, 57-22-7 5978
2
Ifosfamide Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 3778-73-2 3690
3
Prednisone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 53-03-2 5865
4
Epirubicin Approved Phase 4,Phase 2 56420-45-2 41867
5
Cyclophosphamide Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 6055-19-2, 50-18-0 2907
6
Cisplatin Approved Phase 4,Phase 2,Phase 1 15663-27-1 441203 84093 2767
7
Etoposide Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1,Not Applicable 33419-42-0 36462
8
Gemcitabine Approved Phase 4,Phase 2,Phase 1 95058-81-4 60750
9
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 1177-87-3
10
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 50-02-2 5743
11
Epinephrine Approved, Vet_approved Phase 4,Not Applicable 51-43-4 5816
12
Bupivacaine Approved, Investigational Phase 4,Phase 1,Phase 2 2180-92-9, 38396-39-3 2474
13
Racepinephrine Approved Phase 4,Not Applicable 329-65-7 838
14
Zidovudine Approved Phase 4,Phase 2 30516-87-1 35370
15
Ropivacaine Approved Phase 4 84057-95-4 71273 175805
16
Benzocaine Approved, Investigational Phase 4,Phase 2 94-09-7, 1994-09-7 2337
17
tannic acid Approved Phase 4,Phase 2 1401-55-4
18
Peginterferon alfa-2b Approved Phase 4,Phase 2 99210-65-8, 215647-85-1
19
Valproic Acid Approved, Investigational Phase 4 99-66-1 3121
20
Isophosphamide mustard Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 0
21 Anti-Bacterial Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
22 Anti-Inflammatory Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
23 Antineoplastic Agents, Alkylating Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
24 Etoposide phosphate Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1,Not Applicable
25 Hormones Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
26 BB 1101 Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
27 Immunosuppressive Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
28 Antineoplastic Agents, Hormonal Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
29 Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
30 Immunologic Factors Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
31 Topoisomerase Inhibitors Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
32 Alkylating Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
33 Antibiotics, Antitubercular Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
34 Antimitotic Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
35 Antineoplastic Agents, Phytogenic Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
36 Antirheumatic Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
37 glucocorticoids Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
38 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
39 Neurotransmitter Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
40 Anesthetics Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
41 Autonomic Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
42 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
43 Central Nervous System Depressants Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
44 Anti-HIV Agents Phase 4,Phase 2,Phase 1,Not Applicable
45 Anti-Retroviral Agents Phase 4,Phase 2,Phase 1,Not Applicable
46 Nucleic Acid Synthesis Inhibitors Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
47 Antimetabolites Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
48 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
49 Antiviral Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
50 Sympathomimetics Phase 4

Interventional clinical trials:

(show top 50) (show all 386)
# Name Status NCT ID Phase Drugs
1 CEOP/IVE/GDP Compared With CEOP as the First-line Therapy for Newly Diagnosed Adult Patients With PTCL Unknown status NCT02533700 Phase 4 CEOP/IVE/GDP chemotherapy regimen;CEOP chemotherapy regimen for 6 cycles
2 Pilot Study of Combination Therapy With CHOP-Zenapax (CHOP-daclizumab) Completed NCT01418430 Phase 4 CHOP-daclizumab
3 MP Diagnostics HTLV Blot 2.4 Post-Market Clinical Study Completed NCT03226119 Phase 4
4 Postoperative Analgesia After Elective Hip Surgery - Effect of Obturator Nerve Blockade Completed NCT03064165 Phase 4 Bupivacaine-epinephrine;Sodium Chloride 9mg/mL
5 Neurotoxicity of Spinal Anesthesia With Ropivacaine and Bupivacaine Recruiting NCT03293472 Phase 4 Ropivacaine;Bupivacaine
6 Therapeutic Drug Monitoring of Tocilizumab in Rheumatoid Arthritis Recruiting NCT03781310 Phase 4 Tocilizumab
7 Zidovudine, Interferon Alfa-2b, PEG-Interferon Alfa-2b in Patients With HTLV-I Associated Adult T-Cell Leukemia/Lymphoma Terminated NCT00854581 Phase 4 Valproic Acid;Zidovudine
8 Ketamine Hydrochloride and Best Pain Management in Treating Cancer Patients With Neuropathic Pain Unknown status NCT01316744 Phase 3 ketamine hydrochloride
9 Early Hospital Discharge or Standard Inpatient Care in Cancer Patients Receiving Antibiotics for Febrile Neutropenia Unknown status NCT00445497 Phase 3 amoxicillin-clavulanate potassium;ciprofloxacin
10 Levofloxacin Compared With Cefepime in Treating Cancer Patients With Fever and Neutropenia Unknown status NCT00020865 Phase 3 cefepime hydrochloride;levofloxacin
11 Combination Chemotherapy With or Without Rituximab in Treating Older Patients With Non-Hodgkin's Lymphoma Unknown status NCT00052936 Phase 3 CHOP regimen;cyclophosphamide;doxorubicin hydrochloride;prednisone;vincristine sulfate
12 A Study for Aggressive Adult T-cell Leukemia-lymphoma (ATLL) Completed NCT00145002 Phase 3 VCAP-AMP-VECP with G-CSF and intrathecal prophylaxis;biweekly-CHOP with G-CSF and intrathecal prophylaxis
13 Treatment of Acute Lymphoblastic Leukemia (ALL) in Younger Adults Completed NCT00327678 Phase 3 Rituximab;Imatinib Mesylate
14 Combination Chemotherapy in Treating Young Patients With Newly Diagnosed T-Cell Acute Lymphoblastic Leukemia or T-cell Lymphoblastic Lymphoma Completed NCT00408005 Phase 3 Asparaginase;Cyclophosphamide;Cytarabine;Daunorubicin Hydrochloride;Dexamethasone;Doxorubicin Hydrochloride;Leucovorin Calcium;Mercaptopurine;Methotrexate;Nelarabine;Pegaspargase;Prednisone;Thioguanine;Vincristine Sulfate
15 Study of Treatment High Risk and/or Low Risk Acute Lymphoblastic leukémia(ALL) Adults Stage III Completed NCT00483132 Phase 3 interferon alpha 2a
16 ALL2008 Protocol for Childhood Acute Lymphoblastic Leukemia (ALL) - 6MP Consolidation Therapy Completed NCT00816049 Phase 3 6MPindividualized;6MPfixed
17 Radiation Therapy in Treating Patients With Relapsed or Refractory Non-Hodgkin's Lymphoma Who Have Undergone Stem Cell Transplantation Completed NCT00031668 Phase 3
18 Personalized Information or Basic Information in Helping Patients Make Decisions About Participating in a Clinical Trial Completed NCT00750009 Phase 3
19 American Ginseng in Treating Patients With Fatigue Caused by Cancer Completed NCT00719563 Phase 3 American ginseng
20 Opioid Titration Order Sheet or Standard Care in Treating Patients With Cancer Pain Completed NCT00666211 Phase 3
21 Darbepoetin Alfa With or Without Iron in Treating Anemia Caused By Chemotherapy in Patients With Cancer Completed NCT00661999 Phase 3 sodium ferric gluconate complex in sucrose
22 Fentanyl Sublingual Spray in Treating Patients With Breakthrough Cancer Pain Completed NCT00538850 Phase 3 Fentanyl sublingual spray;Placebo
23 St. John's Wort in Relieving Fatigue in Patients Undergoing Chemotherapy or Hormone Therapy for Cancer Completed NCT00005805 Phase 3
24 Prevention of Infection in Patients With Hematologic Cancer and Persistent Fever Caused by a Low White Blood Cell Count Completed NCT00003805 Phase 3 piperacillin sodium;piperacillin-tazobactam;tazobactam sodium;vancomycin
25 Dalteparin to Prevent Complications in Cancer Patients Receiving Chemotherapy Through a Catheter Completed NCT00006083 Phase 3 Fragmin
26 Darbepoetin Alfa Compared With Epoetin Alfa in Treating Anemia in Patients Receiving Chemotherapy for Cancer Completed NCT00070382 Phase 3 darbepoetin alfa;epoetin alfa
27 Caspofungin Acetate Compared With Amphotericin B Liposomal in Treating Patients With Persistent Fever and Neutropenia Following Cancer Treatment Completed NCT00008359 Phase 3 caspofungin acetate;liposomal amphotericin B
28 Levofloxacin to Prevent Infection Following Chemotherapy in Treating Patients With Solid Tumors or Lymphoma Completed NCT00005590 Phase 3 levofloxacin
29 Liposomal Amphotericin B in Treating Granulocytopenia and Persistent Unexplained Fever in Cancer Patients Completed NCT00003938 Phase 3 liposomal amphotericin B
30 Treatment for Chronic Pain in Patients With Advanced Cancer Completed NCT00003687 Phase 3 dextromethorphan hydrobromide;morphine sulfate
31 Ondansetron in Treating Patients With Advanced Cancer and Chronic Nausea and Vomiting Not Caused by Cancer Treatment Completed NCT00006348 Phase 3 ondansetron
32 Stopping Postpartum Vitamin A Supplementation: Missing Concealed Benefit Completed NCT02043223 Phase 2, Phase 3
33 Optimization of Therapy in Adult Patients With Newly Diagnosed Acute Lymphoblastic Leukemia or Lymphoblastic Lymphoma by Individualised, Targeted and Intensified Treatment Recruiting NCT02881086 Phase 3 Rituximab;Nelarabine;PEG-Asparaginase;Imatinib;Idarubicin;Dexamethasone;Cyclophosphamide;Fludarabine;Vincristine;Mercaptopurine;VP16;Daunorubicin (DNR);Methotrexate;Cytarabine;Vindesine;Adriamycin;Prednisolone
34 Total Therapy XVII for Newly Diagnosed Patients With Acute Lymphoblastic Leukemia and Lymphoma Recruiting NCT03117751 Phase 2, Phase 3 Prednisone;Vincristine;Daunorubicin;Pegaspargase;Erwinase®;Rituximab;Cyclophosphamide;Cytarabine;Mercaptopurine;Dasatinib;Methotrexate;Blinatumomab;Ruxolitinib;Bortezomib;Dexamethasone;Doxorubicin;Etoposide;Clofarabine;Vorinostat;Idarubicin;Nelarabine
35 Precision Diagnosis Directing HDACi Chidamide Target Therapy for Adult T-LBL/ALL Recruiting NCT03564704 Phase 2, Phase 3 Dexamethasone;vincristine;Cyclophosphamide;Idarubicin;Pegaspargase;Adriamycin;Methotrexate;6-mercaptopurine.;Etoposide;Cytarabine;Chidamide
36 Treatment Protocol for Children and Adolescents With Acute Lymphoblastic Leukemia - AIEOP-BFM ALL 2017 Recruiting NCT03643276 Phase 3 Blinatumomab;Bortezomib;Cyclophosphamide;Cytarabine;Daunorubicin;DAUNOrubicin Liposomal Injection [DaunoXome];Dexamethasone;Doxorubicin;Etoposide;Fludarabine Phosphate;Ifosfamide;6-Mercaptopurine;Methotrexate;Pegaspargase;Prednisolone;Tioguanin;Vincristine;Vindesine;Erwinase
37 Treatment of Newly Diagnosed Acute Lymphoblastic Leukemia in Children and Adolescents Recruiting NCT03020030 Phase 3 Pegaspargase;Erwinia asparaginase;Cyclophosphamide;CYTARABINE;DASATINIB;DEXAMETHASONE;Dexrazoxane;Doxorubicin;ETOPOSIDE;HYDROCORTISONE;LEUCOVORIN CALCIUM;MERCAPTOPURINE;METHOTREXATE;NELARABINE;Vincristine
38 International Collaborative Treatment Protocol For Children And Adolescents With Acute Lymphoblastic Leukemia Active, not recruiting NCT01117441 Phase 3 PEG-L-asparaginase;cyclophosphamide;cytarabine;daunorubicin hydrochloride;dexamethasone;doxorubicin hydrochloride;etoposide;ifosfamide;mercaptopurine;methotrexate;prednisone;thioguanine;vincristine sulfate;vindesine;daunoxome;fludarabine
39 Combination Chemotherapy and Donor Stem Cell Transplant in Treating Patients With Aplastic Anemia or Hematologic Cancer Active, not recruiting NCT00003816 Phase 2, Phase 3 busulfan;carboplatin;cyclophosphamide;etoposide;fludarabine phosphate;melphalan;thiotepa
40 Combination Chemotherapy With or Without Bortezomib in Treating Younger Patients With Newly Diagnosed T-Cell Acute Lymphoblastic Leukemia or Stage II-IV T-Cell Lymphoblastic Lymphoma Suspended NCT02112916 Phase 3 Bortezomib;Cyclophosphamide;Cytarabine;Daunorubicin Hydrochloride;Dexamethasone;Doxorubicin Hydrochloride;Etoposide;Hydrocortisone Sodium Succinate;Ifosfamide;Leucovorin Calcium;Mercaptopurine;Methotrexate;Pegaspargase;Thioguanine;Vincristine Sulfate
41 Combination Chemotherapy With or Without Etoposide in Treating Older Patients With Non-Hodgkin's Lymphoma Terminated NCT00060385 Phase 2, Phase 3 CHOP regimen;EPOCH regimen;cyclophosphamide;doxorubicin hydrochloride;etoposide;prednisone;vincristine sulfate
42 High-Dose Chemotherapy Given Together With Peripheral Blood Stem Cell Transplant in Treating Patients With Intestinal T-Cell Lymphoma Unknown status NCT00669812 Phase 2 carmustine;cyclophosphamide;cytarabine;doxorubicin hydrochloride;epirubicin hydrochloride;etoposide;ifosfamide;melphalan;methotrexate;prednisolone;vincristine sulfate
43 Brentuximab Vedotin + Rituximab as Frontline Therapy for Pts w/ CD30+ and/or EBV+ Lymphomas Unknown status NCT01805037 Phase 1, Phase 2 brentuximab vedotin
44 Combination Chemotherapy Followed by Donor Bone Marrow Transplant or Peripheral Stem Cell Transplant in Treating Patients With Hematologic Cancer or Genetic Disorders Unknown status NCT00008307 Phase 2 cyclosporine;fludarabine phosphate;melphalan;methylprednisolone;mycophenolate mofetil
45 Alemtuzumab and Combination Chemotherapy in Treating Patients With Newly Diagnosed Stage II, Stage III, or Stage IV T-Cell Non-Hodgkin's Lymphoma Unknown status NCT00363090 Phase 1, Phase 2 cyclophosphamide;doxorubicin hydrochloride;prednisone;vincristine sulfate
46 Stem Cell Transplant in Treating Patients With Hematological Cancer or Other Disorders Unknown status NCT00740467 Phase 2 busulfan;cyclophosphamide;cyclosporine;fludarabine phosphate;mycophenolate mofetil
47 Arsenic Trioxide in Treating Patients With Recurrent or Refractory Acute Leukemia, Chronic Myeloide Leukemia, Myelodysplasia, Lymphoma, or Myeloma Unknown status NCT00003885 Phase 2 arsenic trioxide
48 External-Beam Radiation Therapy With or Without Indinavir and Ritonavir in Treating Patients With Brain Metastases Unknown status NCT00637637 Phase 2 indinavir sulfate;ritonavir
49 KW-0761 or Investigator's Choice in Subjects With Previously Treated Adult T-cell Leukemia-Lymphoma (ATL) Completed NCT01626664 Phase 2 Pralatrexate;gemcitabine plus oxaliplatin;DHAP
50 A Phase 2 Study of Lenalidomide in Patients With Relapsed or Recurrent Adult T-cell Leukemia-lymphoma Completed NCT01724177 Phase 2 Lenalidomide

Search NIH Clinical Center for Adult T-Cell Leukemia

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Adult T-Cell Leukemia cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Adult T-Cell Leukemia:
Hematopoietic stem cells for treatment of hematologic malignancies
Embryonic/Adult Cultured Cells Related to Adult T-Cell Leukemia:
Bone marrow-derived hematopoietic stem cells

Cochrane evidence based reviews: leukemia-lymphoma, adult t-cell

Genetic Tests for Adult T-Cell Leukemia

Anatomical Context for Adult T-Cell Leukemia

MalaCards organs/tissues related to Adult T-Cell Leukemia:

42
T Cells, Bone, Bone Marrow, Skin, Lymph Node, Liver, Thyroid

Publications for Adult T-Cell Leukemia

Articles related to Adult T-Cell Leukemia:

(show top 50) (show all 1886)
# Title Authors Year
1
PAK kinase inhibition has therapeutic activity in novel preclinical models of Adult T-cell Leukemia/Lymphoma. ( 30862694 )
2019
2
Crusted (Norwegian) scabies as a strong marker of adult T-cell leukemia/lymphoma in HTLV-1 infection. ( 30899475 )
2019
3
A Case of Adult T-Cell Leukemia/Lymphoma Complicated with Bilateral Chylothorax. ( 30911425 )
2019
4
Activation of Notch1 signaling by HTLV-1 Tax promotes proliferation of adult T-cell leukemia cells. ( 30914196 )
2019
5
Clinical impact of the CONUT score and mogamulizumab in adult T cell leukemia/lymphoma. ( 30264165 )
2019
6
Thoracic manifestations of adult T-cell leukemia/lymphoma on chest CT: difference between clinical subtypes. ( 30582570 )
2019
7
Adult T-Cell Leukemia-Lymphoma. ( 30596217 )
2019
8
Human leukocyte antigen class II expression is a good prognostic factor of adult T-cell leukemia/lymphoma. ( 30630986 )
2019
9
Association of high levels of plasma OX40 with acute adult T-cell leukemia. ( 30652238 )
2019
10
Granuloma With an Underlying Lymphoma: A Diagnostic Challenge and a Wider Histologic Spectrum Including Adult T-Cell Leukemia/Lymphoma. ( 30653030 )
2019
11
Prognostic impact of soluble interleukin-2 receptor level profiling in smoldering type adult T-cell leukemia-lymphoma. ( 30656718 )
2019
12
Revised Adult T-Cell Leukemia-Lymphoma International Consensus Meeting Report. ( 30657736 )
2019
13
VCAP-AMP-VECP as a preferable induction chemotherapy in transplant-eligible patients with aggressive adult T-cell leukemia-lymphoma: a propensity score analysis. ( 30664725 )
2019
14
Maintenance of long remission in adult T-cell leukemia by Tax-targeted vaccine: a hope for disease-preventive therapy. ( 30666755 )
2019
15
Clinical features at transformation in adult T-cell leukemia-lymphoma with smoldering and chronic types. ( 30680667 )
2019
16
JSH Practical Guidelines for Hematological Malignancies, 2018: II. Lymphoma-8. Adult T-cell leukemia-lymphoma. ( 30701465 )
2019
17
Safety and effectiveness of mogamulizumab in relapsed or refractory adult T-cell leukemia-lymphoma. ( 30740787 )
2019
18
Cytomegalovirus reactivation is associated with increased mortality more than 100 days after allogeneic hematopoietic stem cell transplantation for adult T-cell leukemia/lymphoma. ( 30773707 )
2019
19
Hypericin-photodynamic therapy inhibits the growth of adult T-cell leukemia cells through induction of apoptosis and suppression of viral transcription. ( 30782173 )
2019
20
Cells of adult T-cell leukemia evade HTLV-1 Tax/NF-κB hyperactivation-induced senescence. ( 30787019 )
2019
21
Adult T-cell leukemia/lymphoma with conjunctival chemosis from infiltration and raised intraocular pressure. ( 30851797 )
2019
22
Successful treatment of post-transplant relapsed adult T cell leukemia after cord blood transplantation with low-dose, short-term lenalidomide. ( 29382244 )
2018
23
Indolent, waxing and waning cutaneous presentation of HTLV-1-associated adult T-cell leukemia/lymphoma in an HIV-1-positive patient. ( 29094771 )
2018
24
Complete Sequences of the Human T-Cell Leukemia Virus Type 1 Proviral Genomes from Newly Established Adult T-Cell Leukemia Cell Lines in Oita Prefecture, Japan. ( 29930027 )
2018
25
Retraction notice to Inhibition of proliferation and induction of apoptosis by 2-benzoyl-3-phenyl-6,7-dichloroquinoxaline 1,4-dioxide in adult T-cell leukemia cells. ( 29273235 )
2018
26
Prognostic relevance of integrated genetic profiling in adult T-cell leukemia/lymphoma. ( 29084771 )
2018
27
An activating mutation of interferon regulatory factor 4 (IRF4) in adult T-cell leukemia. ( 29540473 )
2018
28
NF-I_B signaling mechanisms in HTLV-1-induced adult T-cell leukemia/lymphoma. ( 29722927 )
2018
29
Mouse Models That Enhanced Our Understanding of Adult T Cell Leukemia. ( 29643841 )
2018
30
A Review of New Findings in Adult T-cell Leukemia-Lymphoma: A Focus on Current and Emerging Treatment Strategies. ( 29411267 )
2018
31
Cytotoxic T-lymphocyte-associated antigen 4-positive aggressive adult T cell leukemia/lymphoma. ( 29978285 )
2018
32
A genetic IFN/STAT1/FAS axis determines CD4 T stem cell memory levels and apoptosis in healthy controls and Adult T-cell Leukemia patients. ( 29721391 )
2018
33
Development of sugar chain-binding single chain variable fragment antibody to adult T-cell leukemia cells using glyco-nanotechnology and phage display method. ( 29351623 )
2018
34
Syngeneic hematopoietic stem cell transplantation from HTLV-1 seropositive twin for adult T-cell leukemia-lymphoma. ( 29358601 )
2018
35
Impact of pretransplant central nervous system invasion in patients with aggressive adult T-cell leukemia lymphoma. ( 29899570 )
2018
36
Adult T-Cell Leukemia/Lymphoma With Primary Lacrimal Gland Involvement. ( 29068833 )
2018
37
Evaluation of two prognostic indices for adult T-cell leukemia/lymphoma in the subtropical endemic area, Okinawa, Japan. ( 29772611 )
2018
38
Cutaneous presentation of adult T-cell leukemia/lymphoma (ATLL). Single-center study on 37 patients in metropolitan France between 1996 and 2016. ( 29661476 )
2018
39
Targeting General Transcriptional Machinery as a Therapeutic Strategy for Adult T-Cell Leukemia. ( 29724031 )
2018
40
Outcomes of patients with relapsed aggressive adult T-cell leukemia-lymphoma: clinical effectiveness of anti-CCR4 antibody and allogeneic hematopoietic stem cell transplantation. ( 29371324 )
2018
41
Adult T-cell leukemia/lymphoma can be indistinguishable from other more common T-cell lymphomas. The University of Miami experience with a large cohort of cases. ( 29449683 )
2018
42
MicroRNA-3662 expression correlates with antiviral drug resistance in adult T-cell leukemia/lymphoma cells. ( 29684346 )
2018
43
EPOCH regimen as salvage therapy for adult T-cell leukemia-lymphoma. ( 29651666 )
2018
44
A case of adult T-cell leukemia/lymphoma in Korea. ( 29662869 )
2018
45
Adult T-Cell Leukemia/Lymphoma. Review of the Literature. ( 29685460 )
2018
46
Case Report: Orbital Tumor Revealing Adult T-Cell Leukemia/Lymphoma Associated with Human T-Cell Lymphotropic Virus Type-1. ( 29968553 )
2018
47
Adult T cell leukemia/lymphoma with different pathological features in each tumor site. ( 29427186 )
2018
48
Prognostic importance of pretransplant disease status for posttransplant outcomes in patients with adult T cell leukemia/lymphoma. ( 29523883 )
2018
49
Role of up-front allogeneic hematopoietic stem cell transplantation for patients with aggressive adult T-cell leukemia-lymphoma: a decision analysis. ( 29371687 )
2018
50
Future Perspectives on Drug Targeting in Adult T Cell Leukemia-Lymphoma. ( 29867836 )
2018

Variations for Adult T-Cell Leukemia

ClinVar genetic disease variations for Adult T-Cell Leukemia:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 NT5C2 NM_012229.4(NT5C2): c.1100G> A (p.Arg367Gln) single nucleotide variant not provided rs1057519866 GRCh37 Chromosome 10, 104852955: 104852955
2 NT5C2 NM_012229.4(NT5C2): c.1100G> A (p.Arg367Gln) single nucleotide variant not provided rs1057519866 GRCh38 Chromosome 10, 103093198: 103093198
3 NT5C2 NM_012229.4(NT5C2): c.1075A> C (p.Lys359Gln) single nucleotide variant not provided rs1057519867 GRCh38 Chromosome 10, 103093223: 103093223
4 NT5C2 NM_012229.4(NT5C2): c.1075A> C (p.Lys359Gln) single nucleotide variant not provided rs1057519867 GRCh37 Chromosome 10, 104852980: 104852980
5 NT5C2 NM_012229.4(NT5C2): c.1220A> C (p.Asp407Ala) single nucleotide variant not provided rs1057519868 GRCh37 Chromosome 10, 104850745: 104850745
6 NT5C2 NM_012229.4(NT5C2): c.1220A> C (p.Asp407Ala) single nucleotide variant not provided rs1057519868 GRCh38 Chromosome 10, 103090988: 103090988

Expression for Adult T-Cell Leukemia

Search GEO for disease gene expression data for Adult T-Cell Leukemia.

Pathways for Adult T-Cell Leukemia

Pathways related to Adult T-Cell Leukemia according to KEGG:

38
# Name Kegg Source Accession
1 Human T-cell leukemia virus 1 infection hsa05166
2 Viral carcinogenesis hsa05203

GO Terms for Adult T-Cell Leukemia

Cellular components related to Adult T-Cell Leukemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 intracellular GO:0005622 8.32 TP53

Biological processes related to Adult T-Cell Leukemia according to GeneCards Suite gene sharing:

(show all 21)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription, DNA-templated GO:0045893 9.99 EPC1 FOXP3 IRF4 PRDM16 TP53
2 positive regulation of transcription by RNA polymerase II GO:0045944 9.98 BCL11B EPC1 FOXP3 IL2 IRF4 JUND
3 negative regulation of transcription by RNA polymerase II GO:0000122 9.97 EPC1 FOXP3 JUND PRDM16 TP53 TXN
4 immune response GO:0006955 9.93 CCR4 CCR6 CD7 IL2 IL2RA
5 negative regulation of cell proliferation GO:0008285 9.88 BCL11B FOXP3 PTHLH TNFRSF8 TP53
6 cytokine-mediated signaling pathway GO:0019221 9.87 IL2 IL2RA IRF4 TP53
7 negative regulation of inflammatory response GO:0050728 9.75 FOXP3 IL2 IL2RA
8 positive regulation of protein oligomerization GO:0032461 9.58 PMAIP1 TP53
9 T cell activation GO:0042110 9.58 CD7 FOXP3 IRF4
10 negative regulation of immune response GO:0050777 9.56 FOXP3 IL2RA
11 positive regulation of regulatory T cell differentiation GO:0045591 9.55 FOXP3 IL2
12 response to radiation GO:0009314 9.54 CCR4 JUND TXN
13 interleukin-2-mediated signaling pathway GO:0038110 9.52 IL2 IL2RA
14 regulation of mitochondrial membrane permeability GO:0046902 9.51 PMAIP1 TP53
15 negative regulation of T-helper 17 cell differentiation GO:2000320 9.46 FOXP3 IL2
16 T cell homeostasis GO:0043029 9.43 FOXP3 IL2RA PMAIP1
17 regulation of T cell homeostatic proliferation GO:0046013 9.32 IL2 IL2RA
18 osteoblast development GO:0002076 9.3 PTHLH
19 tolerance induction GO:0002507 9.16 CCR4 FOXP3
20 regulation of regulatory T cell differentiation GO:0045589 9.13 FOXP3 IL2 IL2RA
21 negative regulation of lymphocyte proliferation GO:0050672 8.8 FOXP3 IL2 IL2RA

Molecular functions related to Adult T-Cell Leukemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 RNA polymerase II proximal promoter sequence-specific DNA binding GO:0000978 9.02 BCL11B FOXP3 IRF4 JUND TP53

Sources for Adult T-Cell Leukemia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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