MCID: ADL017
MIFTS: 62

Adult T-Cell Leukemia

Categories: Rare diseases, Cancer diseases, Skin diseases, Blood diseases, Immune diseases

Aliases & Classifications for Adult T-Cell Leukemia

MalaCards integrated aliases for Adult T-Cell Leukemia:

Name: Adult T-Cell Leukemia 38 12 37 15
Adult T-Cell Leukemia/lymphoma 12 53 59
Leukemia-Lymphoma, Adult T-Cell 6 44
Atll 53 59
Adult T-Cell Leukaemia/lymphoma 53
T Cell Leukemia Lymphoma Adult 55
Adult T-Cell Lymphoma/leukemia 73
Adult T-Cell Leukaemia 53
Adult T-Cell Lymphoma 53
Leukemia, T-Cell 73

Characteristics:

Orphanet epidemiological data:

59
adult t-cell leukemia/lymphoma
Inheritance: Multigenic/multifactorial,Not applicable; Age of onset: Adult;

Classifications:



External Ids:

Disease Ontology 12 DOID:0050523
ICD10 33 C91.5 C91.50
MeSH 44 D015459
NCIt 50 C3184
Orphanet 59 ORPHA86875
MESH via Orphanet 45 D015459
UMLS via Orphanet 74 C0023493
ICD10 via Orphanet 34 C91.5
KEGG 37 H00009
UMLS 73 C0023493

Summaries for Adult T-Cell Leukemia

NIH Rare Diseases : 53 Adult T-cell leukemia/lymphoma (ATL) is is a rare and aggressive T-cell lymphoma that is linked to infection by the human T-cell lymphotropic virus 1 (HTLV-1). The exact mechanism by which HTLV-I infection causes the ATL is unknown. The clinical features of ATL include generalized swelling of the lymph nodes (lymphadenopathy), increased liver and spleen size (hepatosplenomegaly), immunosuppression, high levels of calcium in the blood, lytic bone lesions (spots that appear as “holes” on a standard bone x-ray), and skin lesions.  There are four basic clinical variants of ATL: acute (60% of cases), lymphomatous (20 % of cases), chronic (10% of cases) and smoldering (10% of cases). The best treatment for these patients is unclear and patients should be enrolled in clinical trials whenever possible. Medication may include CHOP chemotherapy (cyclophosphamide, doxorubicin, vincristine and prednisone) or EPOCH (etoposide, vincristine, doxorubicin, cyclophosphamide and prednisone). In some patients, a bone marrow transplant may be recommended.

MalaCards based summary : Adult T-Cell Leukemia, also known as adult t-cell leukemia/lymphoma, is related to tropical spastic paraparesis and peripheral t-cell lymphoma. An important gene associated with Adult T-Cell Leukemia is PMAIP1 (Phorbol-12-Myristate-13-Acetate-Induced Protein 1), and among its related pathways/superpathways are HTLV-I infection and Viral carcinogenesis. The drugs Cisplatin and Cyclophosphamide have been mentioned in the context of this disorder. Affiliated tissues include t cells, bone and bone marrow, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and Synthetic lethal with MLN4924 (a NAE inhibitor)

Disease Ontology : 12 A T-cell leukemia that results in abnormal increase of lymphocytes, derives from T-cells, has material basis in Human T-lymphotropic virus 1, which is transmitted by sexual contact, transmitted by contaminated needles used by intravenous-drug users, and transmitted by breast feeding. The infection results in_formation_of skin lesions.

Wikipedia : 76 Adult T-cell leukemia/lymphoma (ATL or ATLL) is a rare cancer of the immune system\'s own... more...

Related Diseases for Adult T-Cell Leukemia

Diseases in the T-Cell Leukemia family:

Adult T-Cell Leukemia Acute T Cell Leukemia
Human T-Cell Leukemia Virus Type 1 Human T-Cell Leukemia Virus Type 2
Human T-Cell Leukemia Virus Type 3 Leukemia, B-Cell, Chronic
Leukemia, T-Cell, Chronic

Diseases related to Adult T-Cell Leukemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 148)
# Related Disease Score Top Affiliating Genes
1 tropical spastic paraparesis 32.6 CNTN2 FOXP3 IL2 IL2RA
2 peripheral t-cell lymphoma 30.8 IL2 TNFRSF8 TP53
3 cutaneous t cell lymphoma 30.8 IL2 IL2RA TNFRSF8
4 cervicitis 30.6 CDKN2A IL2 IL2RA
5 combined immunodeficiency, x-linked 30.5 BCL11B IL2 IL2RA
6 mycosis fungoides 30.4 CD7 IL2 IL2RA TNFRSF8
7 acute lymphocytic leukemia 30.3 CDKN2A IL2 TP53
8 sezary's disease 29.9 CD7 IL2 IL2RA TNFRSF8
9 lymphopenia 29.7 FAS FOXP3 IL2 IL2RA
10 b-cell lymphomas 28.6 BCL2L1 CCND2 CDKN2A FAS TNFRSF8 TP53
11 leukemia, chronic lymphocytic 28.2 BCL2L1 CCND2 FAS IL2 IL2RA TNFRSF8
12 t-cell leukemia 26.6 BCL11B BCL2L1 CCND2 CD7 CNTN2 FAS
13 human t-cell leukemia virus type 1 11.5
14 myelopathy, htlv-1-associated 11.5
15 precursor t-cell acute lymphoblastic leukemia 11.4
16 leukemia 11.2
17 lymphoid leukemia 11.1
18 retrovirus-associated myelopathy 11.1
19 lymphoma 11.1
20 brain stem astrocytic neoplasm 10.8 CDKN2A TP53
21 pityriasis lichenoides et varioliformis acuta 10.7 CD7 TNFRSF8
22 keratinizing squamous cell carcinoma 10.6 CDKN2A TP53
23 pityriasis lichenoides 10.6 CD7 TNFRSF8
24 central nervous system lymphoma 10.6 CDKN2A IL2 TP53
25 ocular cancer 10.5 CDKN2A IL2 TP53
26 marek disease 10.5 TNFRSF8 TP53
27 type i 10.5
28 spitz nevus 10.5 CDKN2A TP53
29 caplan's syndrome 10.5 FAS FOXP3
30 hematopoietic stem cell transplantation 10.5
31 cell type cancer 10.4 CDKN2A IL2 TP53
32 retinal cancer 10.4 CCND2 CDKN2A TP53
33 sensory system cancer 10.4 CCND2 CDKN2A TP53
34 colon lymphoma 10.4 CD7 CDKN2A TNFRSF8
35 spastic paraparesis 10.3
36 spasticity 10.3
37 lymphoproliferative syndrome 10.2 FAS IL2 IL2RA
38 pneumonia 10.2
39 pancreas adenocarcinoma 10.2 CDKN2A FOXP3 TP53
40 scabies 10.1
41 graft-versus-host disease 10.1
42 hepatitis 10.1
43 dermatitis 10.1
44 endotheliitis 10.1
45 autoimmune lymphoproliferative syndrome 10.1 FAS IL2 IL2RA
46 anaplastic large cell lymphoma 10.0
47 strongyloidiasis 10.0
48 meningitis 10.0
49 follicular mucinosis 10.0
50 common variable immunodeficiency 10.0 FAS FOXP3 IL2 IL2RA

Graphical network of the top 20 diseases related to Adult T-Cell Leukemia:



Diseases related to Adult T-Cell Leukemia

Symptoms & Phenotypes for Adult T-Cell Leukemia

GenomeRNAi Phenotypes related to Adult T-Cell Leukemia according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.83 IL2 IL2RA JUND TP53 BCL2L1 CDKN2A
2 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.83 FAS IL2 IL2RA JUND TP53 BCL2L1

MGI Mouse Phenotypes related to Adult T-Cell Leukemia:

46 (show all 14)
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 10.37 CADM1 CCND2 BCL11B CD7 BCL2L1 CDKN2A
2 hematopoietic system MP:0005397 10.36 CADM1 EPC1 CCND2 BCL11B CD7 BCL2L1
3 behavior/neurological MP:0005386 10.35 CADM1 CNTN2 CCND2 BCL11B BCL2L1 CDKN2A
4 immune system MP:0005387 10.31 CADM1 EPC1 CCND2 BCL11B CD7 BCL2L1
5 cellular MP:0005384 10.3 BCL2L1 CDKN2A CADM1 BCL11B PRDM16 TP53
6 growth/size/body region MP:0005378 10.29 BCL2L1 CDKN2A CADM1 BCL11B PRDM16 TP53
7 homeostasis/metabolism MP:0005376 10.25 BCL2L1 CDKN2A CCND2 BCL11B JUND PRDM16
8 digestive/alimentary MP:0005381 10.11 CDKN2A PRDM16 TP53 PTHLH IL2RA FOXP3
9 mortality/aging MP:0010768 10.1 CDKN2A CCND2 BCL11B BCL2L1 PRDM16 TP53
10 integument MP:0010771 9.97 BCL2L1 CDKN2A BCL11B PRDM16 TP53 PTHLH
11 liver/biliary system MP:0005370 9.92 CDKN2A CCND2 PRDM16 TP53 JUND FOXP3
12 reproductive system MP:0005389 9.85 BCL2L1 CDKN2A CADM1 CCND2 TP53 PTHLH
13 respiratory system MP:0005388 9.61 CDKN2A PRDM16 TP53 PTHLH JUND IL2RA
14 vision/eye MP:0005391 9.32 CCND2 BCL11B CDKN2A PRDM16 TP53 PTHLH

Drugs & Therapeutics for Adult T-Cell Leukemia

Drugs for Adult T-Cell Leukemia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 438)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cisplatin Approved Phase 4,Phase 2,Phase 1 15663-27-1 84093 441203 2767
2
Cyclophosphamide Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 50-18-0, 6055-19-2 2907
3
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 50-02-2 5743
4
Epirubicin Approved Phase 4,Phase 2 56420-45-2 41867
5
Etoposide Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1,Not Applicable 33419-42-0 36462
6
Gemcitabine Approved Phase 4,Phase 2,Phase 1 95058-81-4 60750
7
Ifosfamide Approved Phase 4,Phase 3,Phase 2,Phase 1 3778-73-2 3690
8
Prednisone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 53-03-2 5865
9
Vincristine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 2068-78-2, 57-22-7 5978
10
Zidovudine Approved Phase 4,Phase 2 30516-87-1 35370
11
Bupivacaine Approved, Investigational Phase 4,Phase 1,Phase 2 2180-92-9, 38396-39-3 2474
12
Ropivacaine Approved Phase 4 84057-95-4 71273 175805
13
Epinephrine Approved, Vet_approved Phase 4,Not Applicable 51-43-4 5816
14
Racepinephrine Approved Phase 4,Not Applicable 329-65-7 838
15
Peginterferon alfa-2b Approved Phase 4,Phase 2 99210-65-8, 215647-85-1
16
Valproic Acid Approved, Investigational Phase 4 99-66-1 3121
17 Alkylating Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
18 Anti-Bacterial Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
19 Antibiotics, Antitubercular Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
20 Anti-Inflammatory Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
21 Antimitotic Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
22 Antineoplastic Agents, Alkylating Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
23 Antineoplastic Agents, Hormonal Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
24 Antineoplastic Agents, Phytogenic Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
25 Antirheumatic Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
26 BB 1101 Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
27 Dexamethasone acetate Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 1177-87-3
28 Etoposide phosphate Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1,Not Applicable
29 glucocorticoids Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
30 Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
31 Hormones Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
32 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
33 Immunosuppressive Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
34
Isophosphamide mustard Phase 4,Phase 3,Phase 2,Phase 1 0
35 Topoisomerase Inhibitors Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
36 Antibodies Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
37 Immunoglobulins Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
38 Anesthetics Phase 4,Phase 3,Phase 1,Phase 2
39 Central Nervous System Depressants Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
40 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
41 Autonomic Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
42 Neurotransmitter Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
43 Anti-HIV Agents Phase 4,Phase 2,Phase 1,Not Applicable
44 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
45 Antimetabolites Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
46 Anti-Retroviral Agents Phase 4,Phase 2,Phase 1,Not Applicable
47 Antiviral Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
48 Nucleic Acid Synthesis Inhibitors Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
49 Immunoglobulin G Phase 4,Phase 1,Phase 2
50 Adrenergic Agents Phase 4,Phase 2

Interventional clinical trials:

(show top 50) (show all 375)
# Name Status NCT ID Phase Drugs
1 CEOP/IVE/GDP Compared With CEOP as the First-line Therapy for Newly Diagnosed Adult Patients With PTCL Unknown status NCT02533700 Phase 4 CEOP/IVE/GDP chemotherapy regimen;CEOP chemotherapy regimen for 6 cycles
2 Pilot Study of Combination Therapy With CHOP-Zenapax (CHOP-daclizumab) Completed NCT01418430 Phase 4 CHOP-daclizumab
3 Neurotoxicity of Spinal Anesthesia With Ropivacaine and Bupivacaine Recruiting NCT03293472 Phase 4 Ropivacaine;Bupivacaine
4 Postoperative Analgesia After Elective Hip Surgery - Effect of Obturator Nerve Blockade Recruiting NCT03064165 Phase 4 Bupivacaine-epinephrine;Sodium Chloride 9mg/mL
5 MP Diagnostics HTLV Blot 2.4 Post-Market Clinical Study Active, not recruiting NCT03226119 Phase 4
6 Zidovudine, Interferon Alfa-2b, PEG-Interferon Alfa-2b in Patients With HTLV-I Associated Adult T-Cell Leukemia/Lymphoma Terminated NCT00854581 Phase 4 Valproic Acid;Zidovudine
7 Ketamine Hydrochloride and Best Pain Management in Treating Cancer Patients With Neuropathic Pain Unknown status NCT01316744 Phase 3 ketamine hydrochloride
8 Early Hospital Discharge or Standard Inpatient Care in Cancer Patients Receiving Antibiotics for Febrile Neutropenia Unknown status NCT00445497 Phase 3 amoxicillin-clavulanate potassium;ciprofloxacin
9 Levofloxacin Compared With Cefepime in Treating Cancer Patients With Fever and Neutropenia Unknown status NCT00020865 Phase 3 cefepime hydrochloride;levofloxacin
10 Combination Chemotherapy With or Without Rituximab in Treating Older Patients With Non-Hodgkin's Lymphoma Unknown status NCT00052936 Phase 3 CHOP regimen;cyclophosphamide;doxorubicin hydrochloride;prednisone;vincristine sulfate
11 A Study for Aggressive Adult T-cell Leukemia-lymphoma (ATLL) Completed NCT00145002 Phase 3 VCAP-AMP-VECP with G-CSF and intrathecal prophylaxis;biweekly-CHOP with G-CSF and intrathecal prophylaxis
12 Treatment of Acute Lymphoblastic Leukemia (ALL) in Younger Adults Completed NCT00327678 Phase 3 Rituximab;Imatinib Mesylate
13 Combination Chemotherapy in Treating Young Patients With Newly Diagnosed T-Cell Acute Lymphoblastic Leukemia or T-cell Lymphoblastic Lymphoma Completed NCT00408005 Phase 3 Asparaginase;Cyclophosphamide;Cytarabine;Daunorubicin Hydrochloride;Dexamethasone;Doxorubicin Hydrochloride;Leucovorin Calcium;Mercaptopurine;Methotrexate;Nelarabine;Pegaspargase;Prednisone;Thioguanine;Vincristine Sulfate
14 Study of Treatment High Risk and/or Low Risk Acute Lymphoblastic leukémia(ALL) Adults Stage III Completed NCT00483132 Phase 3 interferon alpha 2a
15 ALL2008 Protocol for Childhood Acute Lymphoblastic Leukemia (ALL) - 6MP Consolidation Therapy Completed NCT00816049 Phase 3 6MPindividualized;6MPfixed
16 Radiation Therapy in Treating Patients With Relapsed or Refractory Non-Hodgkin's Lymphoma Who Have Undergone Stem Cell Transplantation Completed NCT00031668 Phase 3
17 Personalized Information or Basic Information in Helping Patients Make Decisions About Participating in a Clinical Trial Completed NCT00750009 Phase 3
18 American Ginseng in Treating Patients With Fatigue Caused by Cancer Completed NCT00719563 Phase 3 American ginseng
19 Opioid Titration Order Sheet or Standard Care in Treating Patients With Cancer Pain Completed NCT00666211 Phase 3
20 Darbepoetin Alfa With or Without Iron in Treating Anemia Caused By Chemotherapy in Patients With Cancer Completed NCT00661999 Phase 3 sodium ferric gluconate complex in sucrose
21 Fentanyl Sublingual Spray in Treating Patients With Breakthrough Cancer Pain Completed NCT00538850 Phase 3 Fentanyl sublingual spray;Placebo
22 St. John's Wort in Relieving Fatigue in Patients Undergoing Chemotherapy or Hormone Therapy for Cancer Completed NCT00005805 Phase 3
23 Prevention of Infection in Patients With Hematologic Cancer and Persistent Fever Caused by a Low White Blood Cell Count Completed NCT00003805 Phase 3 piperacillin sodium;piperacillin-tazobactam;tazobactam sodium;vancomycin
24 Dalteparin to Prevent Complications in Cancer Patients Receiving Chemotherapy Through a Catheter Completed NCT00006083 Phase 3 Fragmin
25 Darbepoetin Alfa Compared With Epoetin Alfa in Treating Anemia in Patients Receiving Chemotherapy for Cancer Completed NCT00070382 Phase 3 darbepoetin alfa;epoetin alfa
26 Caspofungin Acetate Compared With Amphotericin B Liposomal in Treating Patients With Persistent Fever and Neutropenia Following Cancer Treatment Completed NCT00008359 Phase 3 caspofungin acetate;liposomal amphotericin B
27 Levofloxacin to Prevent Infection Following Chemotherapy in Treating Patients With Solid Tumors or Lymphoma Completed NCT00005590 Phase 3 levofloxacin
28 Liposomal Amphotericin B in Treating Granulocytopenia and Persistent Unexplained Fever in Cancer Patients Completed NCT00003938 Phase 3 liposomal amphotericin B
29 Treatment for Chronic Pain in Patients With Advanced Cancer Completed NCT00003687 Phase 3 dextromethorphan hydrobromide;morphine sulfate
30 Ondansetron in Treating Patients With Advanced Cancer and Chronic Nausea and Vomiting Not Caused by Cancer Treatment Completed NCT00006348 Phase 3 ondansetron
31 Stopping Postpartum Vitamin A Supplementation: Missing Concealed Benefit Completed NCT02043223 Phase 2, Phase 3
32 Optimization of Therapy in Adult Patients With Newly Diagnosed Acute Lymphoblastic Leukemia or Lymphoblastic Lymphoma by Individualised, Targeted and Intensified Treatment Recruiting NCT02881086 Phase 3 Rituximab;Nelarabine;PEG-Asparaginase;Imatinib;Idarubicin;Dexamethasone;Cyclophosphamide;Fludarabine;Vincristine;Mercaptopurine;VP16;Daunorubicin (DNR);Methotrexate;Cytarabine;Vindesine;Adriamycin;Prednisolone
33 Total Therapy XVII for Newly Diagnosed Patients With Acute Lymphoblastic Leukemia and Lymphoma Recruiting NCT03117751 Phase 2, Phase 3 Prednisone;Vincristine;Daunorubicin;Pegaspargase;Erwinase®;Rituximab;Cyclophosphamide;Cytarabine;Mercaptopurine;Dasatinib;Methotrexate;Blinatumomab;Ruxolitinib;Bortezomib;Dexamethasone;Doxorubicin;Etoposide;Clofarabine;Vorinostat;Idarubicin
34 Precision Diagnosis Directing HDACi Chidamide Target Therapy for Adult T-LBL/ALL Recruiting NCT03564704 Phase 2, Phase 3 Dexamethasone;vincristine;Cyclophosphamide;Idarubicin;Pegaspargase;Adriamycin;Methotrexate;6-mercaptopurine.;Etoposide;Cytarabine;Chidamide
35 Treatment of Newly Diagnosed Acute Lymphoblastic Leukemia in Children and Adolescents Recruiting NCT03020030 Phase 3 Pegaspargase;Erwinia asparaginase;Cyclophosphamide;CYTARABINE;DASATINIB;DEXAMETHASONE;Dexrazoxane;Doxorubicin;ETOPOSIDE;HYDROCORTISONE;LEUCOVORIN CALCIUM;MERCAPTOPURINE;METHOTREXATE;NELARABINE;Vincristine
36 International Collaborative Treatment Protocol For Children And Adolescents With Acute Lymphoblastic Leukemia Active, not recruiting NCT01117441 Phase 3 PEG-L-asparaginase;cyclophosphamide;cytarabine;daunorubicin hydrochloride;dexamethasone;doxorubicin hydrochloride;etoposide;ifosfamide;mercaptopurine;methotrexate;prednisone;thioguanine;vincristine sulfate;vindesine;daunoxome;fludarabine
37 Combination Chemotherapy and Donor Stem Cell Transplant in Treating Patients With Aplastic Anemia or Hematologic Cancer Active, not recruiting NCT00003816 Phase 2, Phase 3 busulfan;carboplatin;cyclophosphamide;etoposide;fludarabine phosphate;melphalan;thiotepa
38 Combination Chemotherapy With or Without Bortezomib in Treating Younger Patients With Newly Diagnosed T-Cell Acute Lymphoblastic Leukemia or Stage II-IV T-Cell Lymphoblastic Lymphoma Suspended NCT02112916 Phase 3 Bortezomib;Cyclophosphamide;Cytarabine;Daunorubicin Hydrochloride;Dexamethasone;Doxorubicin Hydrochloride;Etoposide;Hydrocortisone Sodium Succinate;Ifosfamide;Leucovorin Calcium;Mercaptopurine;Methotrexate;Pegaspargase;Thioguanine;Vincristine Sulfate
39 Combination Chemotherapy With or Without Etoposide in Treating Older Patients With Non-Hodgkin's Lymphoma Terminated NCT00060385 Phase 2, Phase 3 CHOP regimen;EPOCH regimen;cyclophosphamide;doxorubicin hydrochloride;etoposide;prednisone;vincristine sulfate
40 High-Dose Chemotherapy Given Together With Peripheral Blood Stem Cell Transplant in Treating Patients With Intestinal T-Cell Lymphoma Unknown status NCT00669812 Phase 2 carmustine;cyclophosphamide;cytarabine;doxorubicin hydrochloride;epirubicin hydrochloride;etoposide;ifosfamide;melphalan;methotrexate;prednisolone;vincristine sulfate
41 Brentuximab Vedotin + Rituximab as Frontline Therapy for Pts w/ CD30+ and/or EBV+ Lymphomas Unknown status NCT01805037 Phase 1, Phase 2 brentuximab vedotin
42 Combination Chemotherapy Followed by Donor Bone Marrow Transplant or Peripheral Stem Cell Transplant in Treating Patients With Hematologic Cancer or Genetic Disorders Unknown status NCT00008307 Phase 2 cyclosporine;fludarabine phosphate;melphalan;methylprednisolone;mycophenolate mofetil
43 Alemtuzumab and Combination Chemotherapy in Treating Patients With Newly Diagnosed Stage II, Stage III, or Stage IV T-Cell Non-Hodgkin's Lymphoma Unknown status NCT00363090 Phase 1, Phase 2 cyclophosphamide;doxorubicin hydrochloride;prednisone;vincristine sulfate
44 Vaccine Therapy and GM-CSF in Treating Patients With CNS Lymphoma Unknown status NCT00621036 Phase 2 methotrexate;thiotepa
45 Stem Cell Transplant in Treating Patients With Hematological Cancer or Other Disorders Unknown status NCT00740467 Phase 2 busulfan;cyclophosphamide;cyclosporine;fludarabine phosphate;mycophenolate mofetil
46 Arsenic Trioxide in Treating Patients With Recurrent or Refractory Acute Leukemia, Chronic Myeloide Leukemia, Myelodysplasia, Lymphoma, or Myeloma Unknown status NCT00003885 Phase 2 arsenic trioxide
47 External-Beam Radiation Therapy With or Without Indinavir and Ritonavir in Treating Patients With Brain Metastases Unknown status NCT00637637 Phase 2 indinavir sulfate;ritonavir
48 KW-0761 or Investigator's Choice in Subjects With Previously Treated Adult T-cell Leukemia-Lymphoma (ATL) Completed NCT01626664 Phase 2 Pralatrexate;gemcitabine plus oxaliplatin;DHAP
49 A Phase 2 Study of Lenalidomide in Patients With Relapsed or Recurrent Adult T-cell Leukemia-lymphoma Completed NCT01724177 Phase 2 Lenalidomide
50 Lenalidomide in HTLV-1 Adult T-Cell Leukemia Completed NCT01274533 Phase 2 Lenalidomide

Search NIH Clinical Center for Adult T-Cell Leukemia

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Adult T-Cell Leukemia cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Adult T-Cell Leukemia:
Hematopoietic stem cells for treatment of hematologic malignancies
Embryonic/Adult Cultured Cells Related to Adult T-Cell Leukemia:
Bone marrow-derived hematopoietic stem cells

Cochrane evidence based reviews: leukemia-lymphoma, adult t-cell

Genetic Tests for Adult T-Cell Leukemia

Anatomical Context for Adult T-Cell Leukemia

MalaCards organs/tissues related to Adult T-Cell Leukemia:

41
T Cells, Bone, Bone Marrow, Skin, Liver, Thyroid, Breast

Publications for Adult T-Cell Leukemia

Articles related to Adult T-Cell Leukemia:

(show top 50) (show all 925)
# Title Authors Year
1
Successful treatment of post-transplant relapsed adult T cell leukemia after cord blood transplantation with low-dose, short-term lenalidomide. ( 29382244 )
2018
2
Indolent, waxing and waning cutaneous presentation of HTLV-1-associated adult T-cell leukemia/lymphoma in an HIV-1-positive patient. ( 29094771 )
2018
3
Complete Sequences of the Human T-Cell Leukemia Virus Type 1 Proviral Genomes from Newly Established Adult T-Cell Leukemia Cell Lines in Oita Prefecture, Japan. ( 29930027 )
2018
4
Retraction notice to Inhibition of proliferation and induction of apoptosis by 2-benzoyl-3-phenyl-6,7-dichloroquinoxaline 1,4-dioxide in adult T-cell leukemia cells. ( 29273235 )
2018
5
Prognostic relevance of integrated genetic profiling in adult T-cell leukemia/lymphoma. ( 29084771 )
2018
6
An activating mutation of interferon regulatory factor 4 (IRF4) in adult T-cell leukemia. ( 29540473 )
2018
7
NF-I_B signaling mechanisms in HTLV-1-induced adult T-cell leukemia/lymphoma. ( 29722927 )
2018
8
Mouse Models That Enhanced Our Understanding of Adult T Cell Leukemia. ( 29643841 )
2018
9
A Review of New Findings in Adult T-cell Leukemia-Lymphoma: A Focus on Current and Emerging Treatment Strategies. ( 29411267 )
2018
10
Cytotoxic T-lymphocyte-associated antigen 4-positive aggressive adult T cell leukemia/lymphoma. ( 29978285 )
2018
11
A genetic IFN/STAT1/FAS axis determines CD4 T stem cell memory levels and apoptosis in healthy controls and Adult T-cell Leukemia patients. ( 29721391 )
2018
12
Development of sugar chain-binding single chain variable fragment antibody to adult T-cell leukemia cells using glyco-nanotechnology and phage display method. ( 29351623 )
2018
13
Syngeneic hematopoietic stem cell transplantation from HTLV-1 seropositive twin for adult T-cell leukemia-lymphoma. ( 29358601 )
2018
14
Impact of pretransplant central nervous system invasion in patients with aggressive adult T-cell leukemia lymphoma. ( 29899570 )
2018
15
Adult T-Cell Leukemia/Lymphoma With Primary Lacrimal Gland Involvement. ( 29068833 )
2018
16
Evaluation of two prognostic indices for adult T-cell leukemia/lymphoma in the subtropical endemic area, Okinawa, Japan. ( 29772611 )
2018
17
Cutaneous presentation of adult T-cell leukemia/lymphoma (ATLL). Single-center study on 37 patients in metropolitan France between 1996 and 2016. ( 29661476 )
2018
18
Targeting General Transcriptional Machinery as a Therapeutic Strategy for Adult T-Cell Leukemia. ( 29724031 )
2018
19
Outcomes of patients with relapsed aggressive adult T-cell leukemia-lymphoma: clinical effectiveness of anti-CCR4 antibody and allogeneic hematopoietic stem cell transplantation. ( 29371324 )
2018
20
Adult T-cell leukemia/lymphoma can be indistinguishable from other more common T-cell lymphomas. The University of Miami experience with a large cohort of cases. ( 29449683 )
2018
21
MicroRNA-3662 expression correlates with antiviral drug resistance in adult T-cell leukemia/lymphoma cells. ( 29684346 )
2018
22
EPOCH regimen as salvage therapy for adult T-cell leukemia-lymphoma. ( 29651666 )
2018
23
A case of adult T-cell leukemia/lymphoma in Korea. ( 29662869 )
2018
24
Adult T-Cell Leukemia/Lymphoma. Review of the Literature. ( 29685460 )
2018
25
Case Report: Orbital Tumor Revealing Adult T-Cell Leukemia/Lymphoma Associated with Human T-Cell Lymphotropic Virus Type-1. ( 29968553 )
2018
26
Adult T cell leukemia/lymphoma with different pathological features in each tumor site. ( 29427186 )
2018
27
Prognostic importance of pretransplant disease status for posttransplant outcomes in patients with adult T cell leukemia/lymphoma. ( 29523883 )
2018
28
Role of up-front allogeneic hematopoietic stem cell transplantation for patients with aggressive adult T-cell leukemia-lymphoma: a decision analysis. ( 29371687 )
2018
29
Future Perspectives on Drug Targeting in Adult T Cell Leukemia-Lymphoma. ( 29867836 )
2018
30
Deep sequencing of the T cell receptor visualizes reconstitution of T cell immunity in mogamulizumab-treated adult T cell leukemia. ( 29399406 )
2018
31
Dual inhibition of the mTORC1 and mTORC2 signaling pathways is a promising therapeutic target for adult T-cell leukemia. ( 29077243 )
2018
32
Expression pattern of immunosurveillance-related antigen in adult T-cell leukemia/lymphoma. ( 29297942 )
2018
33
Diagnostic challenges of adult T-cell leukemia/lymphoma in North America - a clinical, histological, and immunophenotypic correlation with a workflow proposal. ( 29504866 )
2018
34
CCR4 mutations associated with superior outcome of adult T-cell leukemia/lymphoma under mogamulizumab treatment. ( 29930010 )
2018
35
Rapid Progression of Adult T-Cell Leukemia-Lymphoma after PD-1 Inhibitor Therapy. ( 29768155 )
2018
36
Adult T-Cell Leukemia/Lymphoma. ( 28796966 )
2017
37
Anti-laminin-332-type mucous membrane pemphigoid in a patient with adult T-cell leukemia/lymphoma and graft-versus-host disease. ( 28771781 )
2017
38
Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. ( 28811663 )
2017
39
Evaluation of INOS, ICAM-1, and VCAM-1 gene expression: A study of adult T cell leukemia malignancy associated with HTLV-1. ( 28110427 )
2017
40
Mogamulizumab for the treatment of relapsed or refractory adult T-cell leukemia-lymphoma. ( 28756726 )
2017
41
Generalized rash and lymphocytosis as clinical onset adult T-cell leukemia/lymphoma. ( 28645687 )
2017
42
Dismal outcome of allogeneic hematopoietic stem cell transplantation for relapsed adult T-cell leukemia/lymphoma, a Japanese nation-wide study. ( 28067877 )
2017
43
Human T-Cell Leukemia Virus Type 1 Infection and Adult T-Cell Leukemia. ( 29052136 )
2017
44
Adult T-cell leukemia cell-induced uveitis: rapid increase in adult T-cell leukemia cells disrupts the blood-ocular barrier. ( 28677112 )
2017
45
Hypersensitivity reaction to I^-lactam antibiotics in patients with adult T-cell leukemia/lymphoma treated with mogamulizumaba8c. ( 28793956 )
2017
46
Galectin-9 as a Predictive Marker for the Onset of Immune-Related Adverse Effects Associated with Anti-CCR4 MoAb Therapy in Patients with Adult T Cell Leukemia. ( 28321034 )
2017
47
Altered Expression of Cell Cycle Regulators in Adult T-Cell Leukemia/ Lymphoma Patients. ( 29090234 )
2017
48
Long-term clinical remission maintained after cessation of zidovudine and interferon-I+ therapy in chronic adult T-cell leukemia/lymphoma. ( 29090417 )
2017
49
A Unique T-Cell Receptor Amino Acid Sequence Selected by Human T-Cell Lymphotropic Virus Type 1 Tax301-309-Specific Cytotoxic T Cells in HLA-A24:02-Positive Asymptomatic Carriers and Adult T-Cell Leukemia/Lymphoma Patients. ( 28724766 )
2017
50
Choices and Challenges in the Treatment of Adult T-Cell Leukemia/Lymphoma. ( 28796965 )
2017

Variations for Adult T-Cell Leukemia

ClinVar genetic disease variations for Adult T-Cell Leukemia:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 NT5C2 NM_012229.4(NT5C2): c.1100G> A (p.Arg367Gln) single nucleotide variant not provided rs1057519866 GRCh37 Chromosome 10, 104852955: 104852955
2 NT5C2 NM_012229.4(NT5C2): c.1100G> A (p.Arg367Gln) single nucleotide variant not provided rs1057519866 GRCh38 Chromosome 10, 103093198: 103093198
3 NT5C2 NM_012229.4(NT5C2): c.1075A> C (p.Lys359Gln) single nucleotide variant not provided rs1057519867 GRCh37 Chromosome 10, 104852980: 104852980
4 NT5C2 NM_012229.4(NT5C2): c.1075A> C (p.Lys359Gln) single nucleotide variant not provided rs1057519867 GRCh38 Chromosome 10, 103093223: 103093223
5 NT5C2 NM_012229.4(NT5C2): c.1220A> C (p.Asp407Ala) single nucleotide variant not provided rs1057519868 GRCh37 Chromosome 10, 104850745: 104850745
6 NT5C2 NM_012229.4(NT5C2): c.1220A> C (p.Asp407Ala) single nucleotide variant not provided rs1057519868 GRCh38 Chromosome 10, 103090988: 103090988

Expression for Adult T-Cell Leukemia

Search GEO for disease gene expression data for Adult T-Cell Leukemia.

Pathways for Adult T-Cell Leukemia

Pathways related to Adult T-Cell Leukemia according to KEGG:

37
# Name Kegg Source Accession
1 HTLV-I infection hsa05166
2 Viral carcinogenesis hsa05203

Pathways related to Adult T-Cell Leukemia according to GeneCards Suite gene sharing:

(show all 29)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.7 BCL2L1 CCND2 CDKN2A FAS IL2 IL2RA
2
Show member pathways
13.32 CCND2 FAS IL2 IL2RA JUND TNFRSF8
3
Show member pathways
12.84 BCL2L1 CCND2 FAS IL2 IL2RA TP53
4
Show member pathways
12.71 BCL2L1 CDKN2A FAS PMAIP1 TP53
5
Show member pathways
12.68 CCND2 FAS IL2 IL2RA TP53
6 12.58 BCL2L1 CCND2 CDKN2A FAS IL2 IL2RA
7
Show member pathways
12.54 BCL2L1 CCND2 IL2 IL2RA
8 12.38 BCL11B FAS FOXP3 IL2 IL2RA TNFRSF8
9
Show member pathways
12.35 BCL2L1 IL2 IL2RA TP53
10 12.29 BCL2L1 CCND2 CDKN2A IL2 IL2RA TP53
11
Show member pathways
12.21 BCL2L1 CCND2 CDKN2A FAS PMAIP1 TP53
12 12.17 CCND2 CDKN2A PMAIP1 TP53
13 12.13 BCL11B BCL2L1 CCND2 TP53
14 12.12 BCL2L1 FAS PMAIP1 TXN
15
Show member pathways
11.84 FAS PMAIP1 TP53
16 11.82 CCND2 CDKN2A PMAIP1 TP53
17
Show member pathways
11.72 BCL2L1 FAS PMAIP1
18 11.69 CCND2 PMAIP1 TP53
19 11.68 CD7 IL2 IL2RA
20
Show member pathways
11.64 FOXP3 IL2 IL2RA
21 11.42 BCL2L1 CDKN2A FAS PMAIP1 TP53
22 11.36 FOXP3 IL2 IL2RA
23 11.33 FAS JUND TP53
24
Show member pathways
11.31 BCL2L1 FAS PMAIP1
25 11.22 BCL2L1 PMAIP1 TP53
26
Show member pathways
11.18 BCL2L1 CCND2 FOXP3 IL2 IL2RA
27
Show member pathways
10.95 CDKN2A PMAIP1 TP53
28 10.73 BCL2L1 CDKN2A FAS IL2 TP53
29 10.7 BCL2L1 TP53

GO Terms for Adult T-Cell Leukemia

Biological processes related to Adult T-Cell Leukemia according to GeneCards Suite gene sharing:

(show all 22)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of apoptotic process GO:0043066 9.99 BCL11B BCL2L1 CCND2 FAS IL2 TP53
2 immune response GO:0006955 9.97 CD7 FAS IL2 IL2RA TNFRSF8
3 regulation of apoptotic process GO:0042981 9.92 BCL2L1 FAS PMAIP1 TNFRSF8 TP53
4 apoptotic process GO:0006915 9.87 BCL2L1 CADM1 CDKN2A FAS IL2RA PMAIP1
5 negative regulation of cell proliferation GO:0008285 9.85 BCL11B CDKN2A FOXP3 PTHLH TNFRSF8 TP53
6 activation of cysteine-type endopeptidase activity involved in apoptotic process GO:0006919 9.76 CDKN2A FAS PMAIP1
7 response to radiation GO:0009314 9.67 BCL2L1 JUND TXN
8 positive regulation of intrinsic apoptotic signaling pathway GO:2001244 9.65 BCL2L1 PMAIP1 TP53
9 positive regulation of apoptotic process GO:0043065 9.63 BCL2L1 CDKN2A FAS PMAIP1 TNFRSF8 TP53
10 positive regulation of protein oligomerization GO:0032461 9.61 PMAIP1 TP53
11 T cell homeostasis GO:0043029 9.61 FOXP3 IL2RA PMAIP1
12 replicative senescence GO:0090399 9.59 CDKN2A TP53
13 interleukin-2-mediated signaling pathway GO:0038110 9.57 IL2 IL2RA
14 positive regulation of regulatory T cell differentiation GO:0045591 9.56 FOXP3 IL2
15 negative regulation of T-helper 17 cell differentiation GO:2000320 9.54 FOXP3 IL2
16 regulation of T cell homeostatic proliferation GO:0046013 9.46 IL2 IL2RA
17 regulation of regulatory T cell differentiation GO:0045589 9.43 FOXP3 IL2 IL2RA
18 regulation of mitochondrial membrane permeability GO:0046902 9.13 BCL2L1 PMAIP1 TP53
19 negative regulation of lymphocyte proliferation GO:0050672 8.8 FOXP3 IL2 IL2RA
20 negative regulation of transcription by RNA polymerase II GO:0000122 10.02 EPC1 FOXP3 JUND PRDM16 TP53 TXN
21 positive regulation of transcription by RNA polymerase II GO:0045944 10.01 BCL11B CDKN2A EPC1 FOXP3 IL2 JUND
22 negative regulation of transcription, DNA-templated GO:0045892 10 CDKN2A EPC1 FOXP3 PRDM16 TP53

Molecular functions related to Adult T-Cell Leukemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.58 BCL11B BCL2L1 CADM1 CCND2 CDKN2A CNTN2

Sources for Adult T-Cell Leukemia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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