ATLL
MCID: ADL017
MIFTS: 63

Adult T-Cell Leukemia (ATLL)

Categories: Blood diseases, Cancer diseases, Immune diseases, Rare diseases, Skin diseases

Aliases & Classifications for Adult T-Cell Leukemia

MalaCards integrated aliases for Adult T-Cell Leukemia:

Name: Adult T-Cell Leukemia 38 12 37 15
Adult T-Cell Leukemia/lymphoma 12 53 59
Leukemia-Lymphoma, Adult T-Cell 6 44
Atll 53 59
Adult T-Cell Leukaemia/lymphoma 53
T Cell Leukemia Lymphoma Adult 55
Adult T-Cell Lymphoma/leukemia 73
Adult T-Cell Leukaemia 53
Adult T-Cell Lymphoma 53
Leukemia, T-Cell 73

Characteristics:

Orphanet epidemiological data:

59
adult t-cell leukemia/lymphoma
Inheritance: Multigenic/multifactorial,Not applicable; Age of onset: Adult;

Classifications:



External Ids:

Disease Ontology 12 DOID:0050523
ICD10 33 C91.5 C91.50
MeSH 44 D015459
NCIt 50 C3184
SNOMED-CT 68 77430005
Orphanet 59 ORPHA86875
MESH via Orphanet 45 D015459
UMLS via Orphanet 74 C0023493
ICD10 via Orphanet 34 C91.5
KEGG 37 H00009

Summaries for Adult T-Cell Leukemia

NIH Rare Diseases : 53 Adult T-cell leukemia/lymphoma (ATL) is is a rare and aggressive T-cell lymphoma that is linked to infection by the human T-cell lymphotropic virus 1 (HTLV-1). The exact mechanism by which HTLV-I infection causes the ATL is unknown. The clinical features of ATL include generalized swelling of the lymph nodes (lymphadenopathy), increased liver and spleen size (hepatosplenomegaly), immunosuppression, high levels of calcium in the blood, lytic bone lesions (spots that appear as �??holes�?� on a standard bone x-ray), and skin lesions.  There are four basic clinical variants of ATL: acute (60% of cases), lymphomatous (20 % of cases), chronic (10% of cases) and smoldering (10% of cases). The best treatment for these patients is unclear and patients should be enrolled in clinical trials whenever possible. Medication may include CHOP chemotherapy (cyclophosphamide, doxorubicin, vincristine and prednisone) or EPOCH (etoposide, vincristine, doxorubicin, cyclophosphamide and prednisone). In some patients, a bone marrow transplant may be recommended.

MalaCards based summary : Adult T-Cell Leukemia, also known as adult t-cell leukemia/lymphoma, is related to tropical spastic paraparesis and t-cell adult acute lymphocytic leukemia. An important gene associated with Adult T-Cell Leukemia is PMAIP1 (Phorbol-12-Myristate-13-Acetate-Induced Protein 1), and among its related pathways/superpathways are Human T-cell leukemia virus 1 infection and Viral carcinogenesis. The drugs Cyclophosphamide and Gemcitabine have been mentioned in the context of this disorder. Affiliated tissues include t cells, bone and skin, and related phenotypes are Decreased viability and Decreased viability

Disease Ontology : 12 A T-cell leukemia that results in abnormal increase of lymphocytes, derives from T-cells, has material basis in Human T-lymphotropic virus 1, which is transmitted by sexual contact, transmitted by contaminated needles used by intravenous-drug users, and transmitted by breast feeding. The infection results in_formation_of skin lesions.

Wikipedia : 76 Lymphoma is a group of blood cancers that develop from lymphocytes (a type of white blood cell). The... more...

Related Diseases for Adult T-Cell Leukemia

Diseases in the T-Cell Leukemia family:

Adult T-Cell Leukemia Acute T Cell Leukemia
Human T-Cell Leukemia Virus Type 1 Human T-Cell Leukemia Virus Type 2
Human T-Cell Leukemia Virus Type 3 Leukemia, B-Cell, Chronic
Leukemia, T-Cell, Chronic

Diseases related to Adult T-Cell Leukemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 186)
# Related Disease Score Top Affiliating Genes
1 tropical spastic paraparesis 32.5 CNTN2 FOXP3 IL2 IL2RA
2 t-cell adult acute lymphocytic leukemia 32.1 BCL11B CD7 FOXP3 IL2 IRF4 PTHLH
3 t-cell leukemia 30.9 BCL11B BCL2L1 CCND2 CD7 CNTN2 IL2
4 cutaneous t cell lymphoma 30.6 IL2 IL2RA TNFRSF8
5 mycosis fungoides 30.6 CD7 IL2 IL2RA TNFRSF8
6 htlv-1 associated myelopathy/tropical spastic paraparesis 30.5 FOXP3 IL2RA
7 sezary's disease 30.1 CD7 IL2 IL2RA TNFRSF8
8 lymphopenia 30.0 FOXP3 IL2 IL2RA
9 marek disease 30.0 TNFRSF8 TP53
10 leukemia, acute myeloid 30.0 BCL2L1 CD7 IL2 TP53 XIAP
11 acquired immunodeficiency syndrome 30.0 IL2 IL2RA TP53
12 immunodysregulation, polyendocrinopathy, and enteropathy, x-linked 30.0 FOXP3 IL2 IL2RA
13 b-cell lymphomas 29.8 BCL2L1 CCND2 IRF4 TNFRSF8 TP53
14 diffuse large b-cell lymphoma 29.5 IRF4 TNFRSF8 TP53
15 myeloma, multiple 29.3 BCL2L1 CCND2 IL2 IRF4 PMAIP1 TP53
16 leukemia, chronic lymphocytic 29.2 BCL2L1 CCND2 IL2 IL2RA TNFRSF8 TP53
17 lymphoma, non-hodgkin, familial 28.9 BCL2L1 CCND2 CD7 IL2 IL2RA IRF4
18 human t-cell leukemia virus type 1 11.6
19 myelopathy, htlv-1-associated 11.6
20 precursor t-cell acute lymphoblastic leukemia 11.4
21 leukemia 11.3
22 lymphoma 11.3
23 lymphoid leukemia 11.2
24 retrovirus-associated myelopathy 11.2
25 hematopoietic stem cell transplantation 10.6
26 acute t cell leukemia 10.6
27 spastic paraparesis 10.4
28 pneumonia 10.3
29 anaplastic large cell lymphoma 10.2
30 peripheral t-cell lymphoma 10.2
31 scabies 10.2
32 graft-versus-host disease 10.2
33 dermatitis 10.2
34 myeloid leukemia 10.2
35 pityriasis lichenoides 10.2 CD7 TNFRSF8
36 pityriasis lichenoides et varioliformis acuta 10.2 CD7 TNFRSF8
37 rheumatoid arthritis 10.2
38 arthritis 10.2
39 hepatitis 10.2
40 hepatitis b 10.2
41 strongyloidiasis 10.2
42 follicular mucinosis 10.2
43 cytomegalovirus infection 10.2
44 autoimmune enteropathy 10.2 FOXP3 IL2RA
45 immune deficiency disease 10.1 IL2 IL2RA TNFRSF8
46 colitis 10.1
47 bone resorption disease 10.1
48 norwegian scabies 10.1
49 acute pancreatitis 10.1
50 pancreatitis 10.1

Graphical network of the top 20 diseases related to Adult T-Cell Leukemia:



Diseases related to Adult T-Cell Leukemia

Symptoms & Phenotypes for Adult T-Cell Leukemia

GenomeRNAi Phenotypes related to Adult T-Cell Leukemia according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00106-A-0 10.29 BCL2L1
2 Decreased viability GR00240-S-1 10.29 BCL2L1 TP53 TXN
3 Decreased viability GR00381-A-1 10.29 BCL11B CCND2 SPOCK3
4 Decreased viability GR00402-S-2 10.29 BCL11B BCL2L1 CADM1 CCND2 CD7 CNTN2
5 no effect GR00402-S-1 9.96 BCL11B BCL2L1 CADM1 CCND2 CD7 CNTN2
6 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.77 BCL2L1 EPC1 IL2 IL2RA JUND TP53
7 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.77 BCL2L1 EPC1 IL2 IL2RA JUND TP53

MGI Mouse Phenotypes related to Adult T-Cell Leukemia:

46 (show all 13)
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.36 BCL11B BCL2L1 CADM1 CCND2 CD7 EPC1
2 endocrine/exocrine gland MP:0005379 10.34 BCL11B BCL2L1 CADM1 CCND2 CD7 FOXP3
3 immune system MP:0005387 10.31 BCL11B BCL2L1 CADM1 CCND2 CD7 EPC1
4 cellular MP:0005384 10.29 BCL11B BCL2L1 CADM1 FOXP3 IL2 IRF4
5 growth/size/body region MP:0005378 10.29 BCL11B BCL2L1 CADM1 EPC1 FOXP3 IL2
6 behavior/neurological MP:0005386 10.26 BCL11B BCL2L1 CADM1 CCND2 CNTN2 EPC1
7 homeostasis/metabolism MP:0005376 10.25 BCL11B BCL2L1 CCND2 EPC1 FOXP3 IL2
8 mortality/aging MP:0010768 10.13 BCL11B BCL2L1 CCND2 EPC1 FOXP3 IL2
9 liver/biliary system MP:0005370 9.91 CCND2 FOXP3 IL2 JUND PRDM16 PTHLH
10 reproductive system MP:0005389 9.81 BCL2L1 CADM1 CCND2 FOXP3 IL2 JUND
11 neoplasm MP:0002006 9.73 BCL11B BCL2L1 IL2 IRF4 PTHLH TP53
12 respiratory system MP:0005388 9.5 FOXP3 IL2 IL2RA JUND PRDM16 PTHLH
13 vision/eye MP:0005391 9.23 BCL11B CCND2 FOXP3 IL2 IL2RA PRDM16

Drugs & Therapeutics for Adult T-Cell Leukemia

Drugs for Adult T-Cell Leukemia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 449)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cyclophosphamide Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 6055-19-2, 50-18-0 2907
2
Gemcitabine Approved Phase 4,Phase 2,Phase 1 95058-81-4 60750
3
Vincristine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 57-22-7, 2068-78-2 5978
4
Etoposide Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1,Not Applicable 33419-42-0 36462
5
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 50-02-2 5743
6
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 1177-87-3
7
Cisplatin Approved Phase 4,Phase 2,Phase 1 15663-27-1 2767 441203 84093
8
Ifosfamide Approved Phase 4,Phase 3,Phase 2,Phase 1 3778-73-2 3690
9
Epirubicin Approved Phase 4,Phase 2 56420-45-2 41867
10
Prednisone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 53-03-2 5865
11
Bupivacaine Approved, Investigational Phase 4,Phase 1,Phase 2 2180-92-9, 38396-39-3 2474
12
Racepinephrine Approved Phase 4,Not Applicable 329-65-7 838
13
Epinephrine Approved, Vet_approved Phase 4,Not Applicable 51-43-4 5816
14
Zidovudine Approved Phase 4,Phase 2 30516-87-1 35370
15
Ropivacaine Approved Phase 4 84057-95-4 175805 71273
16
Peginterferon alfa-2b Approved Phase 4,Phase 2 99210-65-8, 215647-85-1
17
Valproic Acid Approved, Investigational Phase 4 99-66-1 3121
18
Isophosphamide mustard Phase 4,Phase 3,Phase 2,Phase 1 0
19 Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
20 Anti-Bacterial Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
21 Antineoplastic Agents, Alkylating Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
22 Topoisomerase Inhibitors Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
23 Antibiotics, Antitubercular Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
24 Immunologic Factors Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
25 Antineoplastic Agents, Hormonal Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
26 Antimitotic Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
27 Alkylating Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
28 Hormones Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
29 Anti-Inflammatory Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
30 Antineoplastic Agents, Phytogenic Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
31 Immunosuppressive Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
32 BB 1101 Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
33 Etoposide phosphate Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1,Not Applicable
34 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
35 Antirheumatic Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
36 glucocorticoids Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
37 Antibodies Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
38 Immunoglobulins Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
39 Central Nervous System Depressants Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
40 Autonomic Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
41 Anesthetics Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
42 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
43 Neurotransmitter Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
44 Antimetabolites Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
45 Antiviral Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
46 Nucleic Acid Synthesis Inhibitors Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
47 Anti-HIV Agents Phase 4,Phase 2,Phase 1,Not Applicable
48 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
49 Anti-Retroviral Agents Phase 4,Phase 2,Phase 1,Not Applicable
50 Immunoglobulin G Phase 4,Phase 1,Phase 2

Interventional clinical trials:

(show top 50) (show all 382)
# Name Status NCT ID Phase Drugs
1 CEOP/IVE/GDP Compared With CEOP as the First-line Therapy for Newly Diagnosed Adult Patients With PTCL Unknown status NCT02533700 Phase 4 CEOP/IVE/GDP chemotherapy regimen;CEOP chemotherapy regimen for 6 cycles
2 Pilot Study of Combination Therapy With CHOP-Zenapax (CHOP-daclizumab) Completed NCT01418430 Phase 4 CHOP-daclizumab
3 MP Diagnostics HTLV Blot 2.4 Post-Market Clinical Study Completed NCT03226119 Phase 4
4 Postoperative Analgesia After Elective Hip Surgery - Effect of Obturator Nerve Blockade Completed NCT03064165 Phase 4 Bupivacaine-epinephrine;Sodium Chloride 9mg/mL
5 Neurotoxicity of Spinal Anesthesia With Ropivacaine and Bupivacaine Recruiting NCT03293472 Phase 4 Ropivacaine;Bupivacaine
6 Therapeutic Drug Monitoring of Tocilizumab in Rheumatoid Arthritis Recruiting NCT03781310 Phase 4 Tocilizumab
7 Zidovudine, Interferon Alfa-2b, PEG-Interferon Alfa-2b in Patients With HTLV-I Associated Adult T-Cell Leukemia/Lymphoma Terminated NCT00854581 Phase 4 Valproic Acid;Zidovudine
8 Ketamine Hydrochloride and Best Pain Management in Treating Cancer Patients With Neuropathic Pain Unknown status NCT01316744 Phase 3 ketamine hydrochloride
9 Early Hospital Discharge or Standard Inpatient Care in Cancer Patients Receiving Antibiotics for Febrile Neutropenia Unknown status NCT00445497 Phase 3 amoxicillin-clavulanate potassium;ciprofloxacin
10 Levofloxacin Compared With Cefepime in Treating Cancer Patients With Fever and Neutropenia Unknown status NCT00020865 Phase 3 cefepime hydrochloride;levofloxacin
11 Combination Chemotherapy With or Without Rituximab in Treating Older Patients With Non-Hodgkin's Lymphoma Unknown status NCT00052936 Phase 3 CHOP regimen;cyclophosphamide;doxorubicin hydrochloride;prednisone;vincristine sulfate
12 A Study for Aggressive Adult T-cell Leukemia-lymphoma (ATLL) Completed NCT00145002 Phase 3 VCAP-AMP-VECP with G-CSF and intrathecal prophylaxis;biweekly-CHOP with G-CSF and intrathecal prophylaxis
13 Treatment of Acute Lymphoblastic Leukemia (ALL) in Younger Adults Completed NCT00327678 Phase 3 Rituximab;Imatinib Mesylate
14 Combination Chemotherapy in Treating Young Patients With Newly Diagnosed T-Cell Acute Lymphoblastic Leukemia or T-cell Lymphoblastic Lymphoma Completed NCT00408005 Phase 3 Asparaginase;Cyclophosphamide;Cytarabine;Daunorubicin Hydrochloride;Dexamethasone;Doxorubicin Hydrochloride;Leucovorin Calcium;Mercaptopurine;Methotrexate;Nelarabine;Pegaspargase;Prednisone;Thioguanine;Vincristine Sulfate
15 Study of Treatment High Risk and/or Low Risk Acute Lymphoblastic leukémia(ALL) Adults Stage III Completed NCT00483132 Phase 3 interferon alpha 2a
16 ALL2008 Protocol for Childhood Acute Lymphoblastic Leukemia (ALL) - 6MP Consolidation Therapy Completed NCT00816049 Phase 3 6MPindividualized;6MPfixed
17 Radiation Therapy in Treating Patients With Relapsed or Refractory Non-Hodgkin's Lymphoma Who Have Undergone Stem Cell Transplantation Completed NCT00031668 Phase 3
18 Personalized Information or Basic Information in Helping Patients Make Decisions About Participating in a Clinical Trial Completed NCT00750009 Phase 3
19 American Ginseng in Treating Patients With Fatigue Caused by Cancer Completed NCT00719563 Phase 3 American ginseng
20 Opioid Titration Order Sheet or Standard Care in Treating Patients With Cancer Pain Completed NCT00666211 Phase 3
21 Darbepoetin Alfa With or Without Iron in Treating Anemia Caused By Chemotherapy in Patients With Cancer Completed NCT00661999 Phase 3 sodium ferric gluconate complex in sucrose
22 Fentanyl Sublingual Spray in Treating Patients With Breakthrough Cancer Pain Completed NCT00538850 Phase 3 Fentanyl sublingual spray;Placebo
23 St. John's Wort in Relieving Fatigue in Patients Undergoing Chemotherapy or Hormone Therapy for Cancer Completed NCT00005805 Phase 3
24 Prevention of Infection in Patients With Hematologic Cancer and Persistent Fever Caused by a Low White Blood Cell Count Completed NCT00003805 Phase 3 piperacillin sodium;piperacillin-tazobactam;tazobactam sodium;vancomycin
25 Dalteparin to Prevent Complications in Cancer Patients Receiving Chemotherapy Through a Catheter Completed NCT00006083 Phase 3 Fragmin
26 Darbepoetin Alfa Compared With Epoetin Alfa in Treating Anemia in Patients Receiving Chemotherapy for Cancer Completed NCT00070382 Phase 3 darbepoetin alfa;epoetin alfa
27 Caspofungin Acetate Compared With Amphotericin B Liposomal in Treating Patients With Persistent Fever and Neutropenia Following Cancer Treatment Completed NCT00008359 Phase 3 caspofungin acetate;liposomal amphotericin B
28 Levofloxacin to Prevent Infection Following Chemotherapy in Treating Patients With Solid Tumors or Lymphoma Completed NCT00005590 Phase 3 levofloxacin
29 Liposomal Amphotericin B in Treating Granulocytopenia and Persistent Unexplained Fever in Cancer Patients Completed NCT00003938 Phase 3 liposomal amphotericin B
30 Treatment for Chronic Pain in Patients With Advanced Cancer Completed NCT00003687 Phase 3 dextromethorphan hydrobromide;morphine sulfate
31 Ondansetron in Treating Patients With Advanced Cancer and Chronic Nausea and Vomiting Not Caused by Cancer Treatment Completed NCT00006348 Phase 3 ondansetron
32 Stopping Postpartum Vitamin A Supplementation: Missing Concealed Benefit Completed NCT02043223 Phase 2, Phase 3
33 Optimization of Therapy in Adult Patients With Newly Diagnosed Acute Lymphoblastic Leukemia or Lymphoblastic Lymphoma by Individualised, Targeted and Intensified Treatment Recruiting NCT02881086 Phase 3 Rituximab;Nelarabine;PEG-Asparaginase;Imatinib;Idarubicin;Dexamethasone;Cyclophosphamide;Fludarabine;Vincristine;Mercaptopurine;VP16;Daunorubicin (DNR);Methotrexate;Cytarabine;Vindesine;Adriamycin;Prednisolone
34 Total Therapy XVII for Newly Diagnosed Patients With Acute Lymphoblastic Leukemia and Lymphoma Recruiting NCT03117751 Phase 2, Phase 3 Prednisone;Vincristine;Daunorubicin;Pegaspargase;Erwinase®;Rituximab;Cyclophosphamide;Cytarabine;Mercaptopurine;Dasatinib;Methotrexate;Blinatumomab;Ruxolitinib;Bortezomib;Dexamethasone;Doxorubicin;Etoposide;Clofarabine;Vorinostat;Idarubicin;Nelarabine
35 Precision Diagnosis Directing HDACi Chidamide Target Therapy for Adult T-LBL/ALL Recruiting NCT03564704 Phase 2, Phase 3 Dexamethasone;vincristine;Cyclophosphamide;Idarubicin;Pegaspargase;Adriamycin;Methotrexate;6-mercaptopurine.;Etoposide;Cytarabine;Chidamide
36 Treatment Protocol for Children and Adolescents With Acute Lymphoblastic Leukemia - AIEOP-BFM ALL 2017 Recruiting NCT03643276 Phase 3 Blinatumomab;Bortezomib;Cyclophosphamide;Cytarabine;Daunorubicin;DAUNOrubicin Liposomal Injection [DaunoXome];Dexamethasone;Doxorubicin;Etoposide;Fludarabine Phosphate;Ifosfamide;6-Mercaptopurine;Methotrexate;Pegaspargase;Prednisolone;Tioguanin;Vincristine;Vindesine;Erwinase
37 Treatment of Newly Diagnosed Acute Lymphoblastic Leukemia in Children and Adolescents Recruiting NCT03020030 Phase 3 Pegaspargase;Erwinia asparaginase;Cyclophosphamide;CYTARABINE;DASATINIB;DEXAMETHASONE;Dexrazoxane;Doxorubicin;ETOPOSIDE;HYDROCORTISONE;LEUCOVORIN CALCIUM;MERCAPTOPURINE;METHOTREXATE;NELARABINE;Vincristine
38 International Collaborative Treatment Protocol For Children And Adolescents With Acute Lymphoblastic Leukemia Active, not recruiting NCT01117441 Phase 3 PEG-L-asparaginase;cyclophosphamide;cytarabine;daunorubicin hydrochloride;dexamethasone;doxorubicin hydrochloride;etoposide;ifosfamide;mercaptopurine;methotrexate;prednisone;thioguanine;vincristine sulfate;vindesine;daunoxome;fludarabine
39 Combination Chemotherapy and Donor Stem Cell Transplant in Treating Patients With Aplastic Anemia or Hematologic Cancer Active, not recruiting NCT00003816 Phase 2, Phase 3 busulfan;carboplatin;cyclophosphamide;etoposide;fludarabine phosphate;melphalan;thiotepa
40 Combination Chemotherapy With or Without Bortezomib in Treating Younger Patients With Newly Diagnosed T-Cell Acute Lymphoblastic Leukemia or Stage II-IV T-Cell Lymphoblastic Lymphoma Suspended NCT02112916 Phase 3 Bortezomib;Cyclophosphamide;Cytarabine;Daunorubicin Hydrochloride;Dexamethasone;Doxorubicin Hydrochloride;Etoposide;Hydrocortisone Sodium Succinate;Ifosfamide;Leucovorin Calcium;Mercaptopurine;Methotrexate;Pegaspargase;Thioguanine;Vincristine Sulfate
41 Combination Chemotherapy With or Without Etoposide in Treating Older Patients With Non-Hodgkin's Lymphoma Terminated NCT00060385 Phase 2, Phase 3 CHOP regimen;EPOCH regimen;cyclophosphamide;doxorubicin hydrochloride;etoposide;prednisone;vincristine sulfate
42 High-Dose Chemotherapy Given Together With Peripheral Blood Stem Cell Transplant in Treating Patients With Intestinal T-Cell Lymphoma Unknown status NCT00669812 Phase 2 carmustine;cyclophosphamide;cytarabine;doxorubicin hydrochloride;epirubicin hydrochloride;etoposide;ifosfamide;melphalan;methotrexate;prednisolone;vincristine sulfate
43 Brentuximab Vedotin + Rituximab as Frontline Therapy for Pts w/ CD30+ and/or EBV+ Lymphomas Unknown status NCT01805037 Phase 1, Phase 2 brentuximab vedotin
44 Combination Chemotherapy Followed by Donor Bone Marrow Transplant or Peripheral Stem Cell Transplant in Treating Patients With Hematologic Cancer or Genetic Disorders Unknown status NCT00008307 Phase 2 cyclosporine;fludarabine phosphate;melphalan;methylprednisolone;mycophenolate mofetil
45 Alemtuzumab and Combination Chemotherapy in Treating Patients With Newly Diagnosed Stage II, Stage III, or Stage IV T-Cell Non-Hodgkin's Lymphoma Unknown status NCT00363090 Phase 1, Phase 2 cyclophosphamide;doxorubicin hydrochloride;prednisone;vincristine sulfate
46 Stem Cell Transplant in Treating Patients With Hematological Cancer or Other Disorders Unknown status NCT00740467 Phase 2 busulfan;cyclophosphamide;cyclosporine;fludarabine phosphate;mycophenolate mofetil
47 Arsenic Trioxide in Treating Patients With Recurrent or Refractory Acute Leukemia, Chronic Myeloide Leukemia, Myelodysplasia, Lymphoma, or Myeloma Unknown status NCT00003885 Phase 2 arsenic trioxide
48 External-Beam Radiation Therapy With or Without Indinavir and Ritonavir in Treating Patients With Brain Metastases Unknown status NCT00637637 Phase 2 indinavir sulfate;ritonavir
49 KW-0761 or Investigator's Choice in Subjects With Previously Treated Adult T-cell Leukemia-Lymphoma (ATL) Completed NCT01626664 Phase 2 Pralatrexate;gemcitabine plus oxaliplatin;DHAP
50 A Phase 2 Study of Lenalidomide in Patients With Relapsed or Recurrent Adult T-cell Leukemia-lymphoma Completed NCT01724177 Phase 2 Lenalidomide

Search NIH Clinical Center for Adult T-Cell Leukemia

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Adult T-Cell Leukemia cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Adult T-Cell Leukemia:
Hematopoietic stem cells for treatment of hematologic malignancies
Embryonic/Adult Cultured Cells Related to Adult T-Cell Leukemia:
Bone marrow-derived hematopoietic stem cells

Cochrane evidence based reviews: leukemia-lymphoma, adult t-cell

Genetic Tests for Adult T-Cell Leukemia

Anatomical Context for Adult T-Cell Leukemia

MalaCards organs/tissues related to Adult T-Cell Leukemia:

41
T Cells, Bone, Skin, Bone Marrow, Lymph Node, Liver, Breast

Publications for Adult T-Cell Leukemia

Articles related to Adult T-Cell Leukemia:

(show top 50) (show all 1317)
# Title Authors Year
1
Successful treatment of post-transplant relapsed adult T cell leukemia after cord blood transplantation with low-dose, short-term lenalidomide. ( 29382244 )
2018
2
Indolent, waxing and waning cutaneous presentation of HTLV-1-associated adult T-cell leukemia/lymphoma in an HIV-1-positive patient. ( 29094771 )
2018
3
Complete Sequences of the Human T-Cell Leukemia Virus Type 1 Proviral Genomes from Newly Established Adult T-Cell Leukemia Cell Lines in Oita Prefecture, Japan. ( 29930027 )
2018
4
Retraction notice to Inhibition of proliferation and induction of apoptosis by 2-benzoyl-3-phenyl-6,7-dichloroquinoxaline 1,4-dioxide in adult T-cell leukemia cells. ( 29273235 )
2018
5
Prognostic relevance of integrated genetic profiling in adult T-cell leukemia/lymphoma. ( 29084771 )
2018
6
An activating mutation of interferon regulatory factor 4 (IRF4) in adult T-cell leukemia. ( 29540473 )
2018
7
NF-I_B signaling mechanisms in HTLV-1-induced adult T-cell leukemia/lymphoma. ( 29722927 )
2018
8
Mouse Models That Enhanced Our Understanding of Adult T Cell Leukemia. ( 29643841 )
2018
9
A Review of New Findings in Adult T-cell Leukemia-Lymphoma: A Focus on Current and Emerging Treatment Strategies. ( 29411267 )
2018
10
Cytotoxic T-lymphocyte-associated antigen 4-positive aggressive adult T cell leukemia/lymphoma. ( 29978285 )
2018
11
A genetic IFN/STAT1/FAS axis determines CD4 T stem cell memory levels and apoptosis in healthy controls and Adult T-cell Leukemia patients. ( 29721391 )
2018
12
Development of sugar chain-binding single chain variable fragment antibody to adult T-cell leukemia cells using glyco-nanotechnology and phage display method. ( 29351623 )
2018
13
Syngeneic hematopoietic stem cell transplantation from HTLV-1 seropositive twin for adult T-cell leukemia-lymphoma. ( 29358601 )
2018
14
Impact of pretransplant central nervous system invasion in patients with aggressive adult T-cell leukemia lymphoma. ( 29899570 )
2018
15
Adult T-Cell Leukemia/Lymphoma With Primary Lacrimal Gland Involvement. ( 29068833 )
2018
16
Evaluation of two prognostic indices for adult T-cell leukemia/lymphoma in the subtropical endemic area, Okinawa, Japan. ( 29772611 )
2018
17
Cutaneous presentation of adult T-cell leukemia/lymphoma (ATLL). Single-center study on 37 patients in metropolitan France between 1996 and 2016. ( 29661476 )
2018
18
Targeting General Transcriptional Machinery as a Therapeutic Strategy for Adult T-Cell Leukemia. ( 29724031 )
2018
19
Outcomes of patients with relapsed aggressive adult T-cell leukemia-lymphoma: clinical effectiveness of anti-CCR4 antibody and allogeneic hematopoietic stem cell transplantation. ( 29371324 )
2018
20
Adult T-cell leukemia/lymphoma can be indistinguishable from other more common T-cell lymphomas. The University of Miami experience with a large cohort of cases. ( 29449683 )
2018
21
MicroRNA-3662 expression correlates with antiviral drug resistance in adult T-cell leukemia/lymphoma cells. ( 29684346 )
2018
22
EPOCH regimen as salvage therapy for adult T-cell leukemia-lymphoma. ( 29651666 )
2018
23
A case of adult T-cell leukemia/lymphoma in Korea. ( 29662869 )
2018
24
Adult T-Cell Leukemia/Lymphoma. Review of the Literature. ( 29685460 )
2018
25
Case Report: Orbital Tumor Revealing Adult T-Cell Leukemia/Lymphoma Associated with Human T-Cell Lymphotropic Virus Type-1. ( 29968553 )
2018
26
Adult T cell leukemia/lymphoma with different pathological features in each tumor site. ( 29427186 )
2018
27
Prognostic importance of pretransplant disease status for posttransplant outcomes in patients with adult T cell leukemia/lymphoma. ( 29523883 )
2018
28
Role of up-front allogeneic hematopoietic stem cell transplantation for patients with aggressive adult T-cell leukemia-lymphoma: a decision analysis. ( 29371687 )
2018
29
Future Perspectives on Drug Targeting in Adult T Cell Leukemia-Lymphoma. ( 29867836 )
2018
30
Deep sequencing of the T cell receptor visualizes reconstitution of T cell immunity in mogamulizumab-treated adult T cell leukemia. ( 29399406 )
2018
31
Dual inhibition of the mTORC1 and mTORC2 signaling pathways is a promising therapeutic target for adult T-cell leukemia. ( 29077243 )
2018
32
Expression pattern of immunosurveillance-related antigen in adult T-cell leukemia/lymphoma. ( 29297942 )
2018
33
Diagnostic challenges of adult T-cell leukemia/lymphoma in North America - a clinical, histological, and immunophenotypic correlation with a workflow proposal. ( 29504866 )
2018
34
Adult T-cell leukemia/lymphoma and acquired immunodeficiency syndrome - CD4+ T-cell malignancy in CD4+ T-cell deficient status: A paradox. ( 30303147 )
2018
35
Epidemiology of malignant lymphoma and recent progress in research on adult T-cell leukemia/lymphoma in Japan. ( 29502313 )
2018
36
Rapid Progression of Adult T-Cell Leukemia-Lymphoma after PD-1 Inhibitor Therapy. ( 29768155 )
2018
37
CCR4 mutations associated with superior outcome of adult T-cell leukemia/lymphoma under mogamulizumab treatment. ( 29930010 )
2018
38
Mutational Intratumor Heterogeneity is a Complex and Early Event in the Development of Adult T-cell Leukemia/Lymphoma. ( 30032036 )
2018
39
Clinical factors to predict outcome following mogamulizumab in adult T-cell leukemia-lymphoma. ( 30032392 )
2018
40
Phosphatidylinositol 3-kinase-δ (PI3K-δ) is a potential therapeutic target in adult T-cell leukemia-lymphoma. ( 30034808 )
2018
41
Chronic inflammatory demyelinating polyneuropathy in adult T-cell leukemia-lymphoma patients following allogeneic stem cell transplantation. ( 30038356 )
2018
42
Adult T Cell Leukemia-Lymphoma (ATL): State of the Art. ( 30047026 )
2018
43
Targeting the HTLV-I-Regulated BATF3/IRF4 Transcriptional Network in Adult T Cell Leukemia/Lymphoma. ( 30057145 )
2018
44
In vitro effects of arsenic trioxide, interferon α and zidovudine in adult T cell leukemia/lymphoma cells. ( 30061950 )
2018
45
HTLV-1-Mediated Epigenetic Pathway to Adult T-Cell Leukemia-Lymphoma. ( 30087673 )
2018
46
The clinical impact of human T-lymphotrophic virus type 1 (HTLV-1) infection on the development of adult T-cell leukemia-lymphoma (ATL) or HTLV-1-associated myelopathy (HAM) / atypical HAM after allogeneic hematopoietic stem cell transplantation (allo-HSCT) and renal transplantation. ( 30089749 )
2018
47
Bullous CD4+ CD8+ adult T-cell leukemia/lymphoma, a rare diagnostically challenging cutaneous variant. ( 30091222 )
2018
48
PD-1 Inhibitor Therapy in Adult T-Cell Leukemia-Lymphoma. ( 30110590 )
2018
49
Outcome of allogeneic hematopoietic cell transplantation in patients with adult T-cell leukemia. ( 30117169 )
2018
50
PD-1 Inhibitor Therapy in Adult T-Cell Leukemia–Lymphoma. ( 30124278 )
2018

Variations for Adult T-Cell Leukemia

ClinVar genetic disease variations for Adult T-Cell Leukemia:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 NT5C2 NM_012229.4(NT5C2): c.1100G> A (p.Arg367Gln) single nucleotide variant not provided rs1057519866 GRCh37 Chromosome 10, 104852955: 104852955
2 NT5C2 NM_012229.4(NT5C2): c.1100G> A (p.Arg367Gln) single nucleotide variant not provided rs1057519866 GRCh38 Chromosome 10, 103093198: 103093198
3 NT5C2 NM_012229.4(NT5C2): c.1075A> C (p.Lys359Gln) single nucleotide variant not provided rs1057519867 GRCh37 Chromosome 10, 104852980: 104852980
4 NT5C2 NM_012229.4(NT5C2): c.1075A> C (p.Lys359Gln) single nucleotide variant not provided rs1057519867 GRCh38 Chromosome 10, 103093223: 103093223
5 NT5C2 NM_012229.4(NT5C2): c.1220A> C (p.Asp407Ala) single nucleotide variant not provided rs1057519868 GRCh37 Chromosome 10, 104850745: 104850745
6 NT5C2 NM_012229.4(NT5C2): c.1220A> C (p.Asp407Ala) single nucleotide variant not provided rs1057519868 GRCh38 Chromosome 10, 103090988: 103090988

Expression for Adult T-Cell Leukemia

Search GEO for disease gene expression data for Adult T-Cell Leukemia.

Pathways for Adult T-Cell Leukemia

Pathways related to Adult T-Cell Leukemia according to KEGG:

37
# Name Kegg Source Accession
1 Human T-cell leukemia virus 1 infection hsa05166
2 Viral carcinogenesis hsa05203

Pathways related to Adult T-Cell Leukemia according to GeneCards Suite gene sharing:

(show all 29)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.32 CCND2 IL2 IL2RA JUND TNFRSF8 TP53
2
Show member pathways
12.68 BCL2L1 IRF4 PMAIP1 TP53 XIAP
3 12.52 BCL2L1 CCND2 IL2 IL2RA PMAIP1 TP53
4
Show member pathways
12.43 BCL2L1 FOXP3 IL2 IL2RA IRF4
5
Show member pathways
12.34 BCL2L1 IL2 IL2RA TP53
6
Show member pathways
12.3 BCL2L1 CCND2 IL2 IL2RA
7
Show member pathways
12.25 BCL2L1 CCND2 PMAIP1 TP53
8 12.13 BCL11B BCL2L1 CCND2 TP53
9 12.1 BCL2L1 PMAIP1 TXN XIAP
10 12.04 BCL2L1 CCND2 IL2 IL2RA TP53 XIAP
11
Show member pathways
12.02 BCL2L1 CCND2 IL2RA TP53 XIAP
12 12.01 BCL11B FOXP3 IL2 IL2RA IRF4 TNFRSF8
13 12 BCL2L1 IL2RA TP53 XIAP
14 11.88 CCND2 PMAIP1 TP53
15 11.87 BCL2L1 IRF4 TP53
16
Show member pathways
11.85 BCL2L1 PMAIP1 TP53 XIAP
17 11.77 BCL2L1 TP53 XIAP
18
Show member pathways
11.7 BCL2L1 PMAIP1 XIAP
19 11.68 CCND2 PMAIP1 TP53
20
Show member pathways
11.61 BCL2L1 TNFRSF8 XIAP
21 11.61 CD7 IL2 IL2RA IRF4
22
Show member pathways
11.55 FOXP3 IL2 IL2RA IRF4
23 11.49 BCL2L1 PMAIP1 TP53 XIAP
24 11.41 BCL2L1 IL2 TP53
25 11.35 FOXP3 IL2 IL2RA
26 11.22 BCL2L1 PMAIP1 TP53
27
Show member pathways
11.1 IL2 IL2RA JUND
28
Show member pathways
10.85 BCL2L1 CCND2 FOXP3 IL2 IL2RA
29 10.69 BCL2L1 TP53

GO Terms for Adult T-Cell Leukemia

Biological processes related to Adult T-Cell Leukemia according to GeneCards Suite gene sharing:

(show all 22)
# Name GO ID Score Top Affiliating Genes
1 apoptotic process GO:0006915 9.97 BCL2L1 CADM1 IL2RA PMAIP1 TP53 XIAP
2 negative regulation of apoptotic process GO:0043066 9.93 BCL11B BCL2L1 CCND2 IL2 TP53 XIAP
3 negative regulation of cell proliferation GO:0008285 9.92 BCL11B FOXP3 PTHLH TNFRSF8 TP53
4 negative regulation of inflammatory response GO:0050728 9.76 FOXP3 IL2 IL2RA
5 cytokine-mediated signaling pathway GO:0019221 9.72 BCL2L1 IL2 IL2RA IRF4 TP53
6 T cell activation GO:0042110 9.65 CD7 FOXP3 IRF4
7 osteoblast development GO:0002076 9.61 JUND PTHLH
8 positive regulation of intrinsic apoptotic signaling pathway GO:2001244 9.61 BCL2L1 PMAIP1 TP53
9 positive regulation of protein oligomerization GO:0032461 9.59 PMAIP1 TP53
10 negative regulation of immune response GO:0050777 9.58 FOXP3 IL2RA
11 response to radiation GO:0009314 9.58 BCL2L1 JUND TXN
12 positive regulation of regulatory T cell differentiation GO:0045591 9.57 FOXP3 IL2
13 interleukin-2-mediated signaling pathway GO:0038110 9.56 IL2 IL2RA
14 negative regulation of T-helper 17 cell differentiation GO:2000320 9.54 FOXP3 IL2
15 T cell homeostasis GO:0043029 9.43 FOXP3 IL2RA PMAIP1
16 regulation of T cell homeostatic proliferation GO:0046013 9.37 IL2 IL2RA
17 regulation of regulatory T cell differentiation GO:0045589 9.33 FOXP3 IL2 IL2RA
18 regulation of mitochondrial membrane permeability GO:0046902 9.13 BCL2L1 PMAIP1 TP53
19 negative regulation of lymphocyte proliferation GO:0050672 8.8 FOXP3 IL2 IL2RA
20 positive regulation of transcription by RNA polymerase II GO:0045944 10.05 BCL11B EPC1 FOXP3 IL2 IRF4 JUND
21 negative regulation of transcription by RNA polymerase II GO:0000122 10.02 EPC1 FOXP3 JUND PRDM16 TP53 TXN
22 positive regulation of transcription, DNA-templated GO:0045893 10 EPC1 FOXP3 IRF4 PRDM16 TP53

Molecular functions related to Adult T-Cell Leukemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 RNA polymerase II proximal promoter sequence-specific DNA binding GO:0000978 9.02 BCL11B FOXP3 IRF4 JUND TP53

Sources for Adult T-Cell Leukemia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
Content
Loading form....