MCID: ADL057
MIFTS: 29

Adult Teratoma

Categories: Cancer diseases, Reproductive diseases

Aliases & Classifications for Adult Teratoma

MalaCards integrated aliases for Adult Teratoma:

Name: Adult Teratoma 12 15 70

Classifications:



External Ids:

Disease Ontology 12 DOID:5565
NCIt 50 C9013
SNOMED-CT 67 42717009
UMLS 70 C1368898

Summaries for Adult Teratoma

Disease Ontology : 12 A benign teratoma that is present in an adult.

MalaCards based summary : Adult Teratoma is related to teratoma and sclerosing hepatic carcinoma. An important gene associated with Adult Teratoma is AFP (Alpha Fetoprotein). The drugs Paclitaxel and Cisplatin have been mentioned in the context of this disorder. Affiliated tissues include liver, thyroid and ovary, and related phenotype is muscle.

Related Diseases for Adult Teratoma

Diseases in the Teratoma family:

Benign Teratoma Malignant Teratoma
Adult Teratoma Intermediate Malignant Teratoma

Diseases related to Adult Teratoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 169)
# Related Disease Score Top Affiliating Genes
1 teratoma 29.9 TP53 CHGA CEACAM5 AFP
2 sclerosing hepatic carcinoma 10.2 CHGA AFP
3 endometrial small cell carcinoma 10.2 CHGA AFP
4 pancreatic acinar cell adenocarcinoma 10.2 CHGA AFP
5 liver leiomyosarcoma 10.2 CHGA AFP
6 testicular fibroma 10.2 BSG AFP
7 pancreatoblastoma 10.2 CHGA AFP
8 pancreatic endocrine carcinoma 10.2 CHGA AFP
9 liver lipoma 10.2 CEACAM5 AFP
10 gestational ovarian choriocarcinoma 10.2 CEACAM5 AFP
11 immature teratoma of ovary 10.2 CEACAM5 AFP
12 urachal adenocarcinoma 10.2 CEACAM5 AFP
13 liver inflammatory pseudotumor 10.2 CEACAM5 AFP
14 rectum signet ring adenocarcinoma 10.2 CEACAM5 AFP
15 dermoid cyst of ovary 10.2 CEACAM5 AFP
16 renal pelvis adenocarcinoma 10.2 CEACAM5 AFP
17 bile duct cystadenocarcinoma 10.2 CEACAM5 AFP
18 colonic lymphangioma 10.2 CEACAM5 AFP
19 paratesticular lipoma 10.2 CEACAM5 AFP
20 lipoma of spermatic cord 10.2 CEACAM5 AFP
21 liver leiomyoma 10.2 CEACAM5 AFP
22 ovarian mixed germ cell neoplasm 10.2 CEACAM5 AFP
23 liver sarcoma 10.2 CEACAM5 AFP
24 sarcomatous intrahepatic cholangiocarcinoma 10.2 CEACAM5 AFP
25 vaginal glandular tumor 10.2 CHGA CEACAM5
26 vulvar eccrine porocarcinoma 10.2 CHGA CEACAM5
27 pancreatic serous cystadenocarcinoma 10.2 CHGA CEACAM5
28 vaginal tubulovillous adenoma 10.2 CHGA CEACAM5
29 female urethral cancer 10.2 CHGA CEACAM5
30 papillary thymic adenocarcinoma 10.2 CHGA CEACAM5
31 common bile duct disease 10.2 CEACAM5 AFP
32 abdominal tuberculosis 10.2 CEACAM5 AFP
33 pancreatic serous cystadenoma 10.2 CHGA CEACAM5
34 bile duct cysts 10.2 CEACAM5 AFP
35 gastric small cell carcinoma 10.1 CHGA CEACAM5
36 appendiceal neoplasm 10.1 CHGA CEACAM5
37 ovarian germ cell cancer 10.1 CEACAM5 AFP
38 malignant teratoma 10.1 CEACAM5 AFP
39 seminal vesicle adenocarcinoma 10.1 CEACAM5 AFP
40 colon neuroendocrine neoplasm 10.1 CHGA CEACAM5
41 large intestine lipoma 10.1 CHGA CEACAM5
42 hepatic tuberculosis 10.1 CEACAM5 AFP
43 intracystic papillary adenoma 10.1 CHGA CEACAM5
44 lipoma of colon 10.1 CHGA CEACAM5
45 pineoblastoma 10.1 CEACAM5 AFP
46 non-gestational ovarian choriocarcinoma 10.1 TP53 AFP
47 cecal disease 10.1 CHGA CEACAM5
48 intratubular embryonal carcinoma 10.1 TP53 AFP
49 sex cord-gonadal stromal tumor 10.1 CEACAM5 AFP
50 thyroid gland medullary carcinoma 10.1 CHGA CEACAM5

Graphical network of the top 20 diseases related to Adult Teratoma:



Diseases related to Adult Teratoma

Symptoms & Phenotypes for Adult Teratoma

MGI Mouse Phenotypes related to Adult Teratoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 muscle MP:0005369 9.02 BSG CHGA ENG FGFR2 TP53

Drugs & Therapeutics for Adult Teratoma

Drugs for Adult Teratoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 25)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Paclitaxel Approved, Vet_approved Phase 3 33069-62-4 36314
2
Cisplatin Approved Phase 3 15663-27-1 84093 441203 2767
3
Etoposide Approved Phase 3 33419-42-0 36462
4
Bleomycin Approved, Investigational Phase 3 11056-06-7 5360373
5
Ifosfamide Approved Phase 3 3778-73-2 3690
6
Oxaliplatin Approved, Investigational Phase 3 61825-94-3 5310940 9887054 6857599 43805
7 Antimitotic Agents Phase 3
8 Albumin-Bound Paclitaxel Phase 3
9 Tubulin Modulators Phase 3
10 Etoposide phosphate Phase 3
11 Antibiotics, Antitubercular Phase 3
12 Anti-Bacterial Agents Phase 3
13
Isophosphamide mustard Phase 3 100427
14 Alkylating Agents Phase 3
15
Sunitinib Approved, Investigational Phase 2 341031-54-7, 557795-19-4 5329102
16
Vincristine Approved, Investigational Phase 2 2068-78-2, 57-22-7 5978
17
Lenograstim Approved, Investigational Phase 2 135968-09-1
18
Carboplatin Approved Phase 2 41575-94-4 10339178 498142 38904
19
Mesna Approved, Investigational Phase 2 3375-50-6 598
20
Thiotepa Approved, Investigational Phase 2 52-24-4 5453
21 Angiogenesis Inhibitors Phase 2
22 Protein Kinase Inhibitors Phase 2
23 Immunosuppressive Agents Phase 2
24 Protective Agents Phase 2
25 Immunologic Factors Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Randomized Phase II/III Study of Taxol/Paclitaxel-BEP Versus BEP in Patients With Intermediate Prognosis Germ Cell Cancer Unknown status NCT00003643 Phase 2, Phase 3 cisplatin;etoposide;paclitaxel
2 A Risk-Adapted Strategy of the Use of Dose-Dense Chemotherapy in Patients With Poor-Prognosis Disseminated Non-Seminomatous Germ Cell Tumors Active, not recruiting NCT00104676 Phase 3 cisplatin;etoposide;ifosfamide;oxaliplatin;paclitaxel
3 A Phase II Study of Sunitinib in Patients With Refractory or Relapsed Germ Cell Tumors Completed NCT00453310 Phase 2 sunitinib malate
4 Accelerated BEP Chemotherapy for Intermediate and High Risk Metastatic Germ Cell Tumor Completed NCT00453232 Phase 2 cisplatin;etoposide
5 Phase I/II Trial of Sequential Paclitaxel/Ifosfamide Followed by Dose-Escalated, Dose-Intensive Carboplatin, Paclitaxel and Ifosfamide With Stem Cell Support in Cisplatin-Resistant Germ Cell Tumor Patients Completed NCT00423852 Phase 1, Phase 2 carboplatin;ifosfamide;paclitaxel
6 Tandem High-Dose Chemotherapy With Autologous Stem Cell Rescue for Poor-Prognosis Germ Cell Cancer Completed NCT00002931 Phase 2 carboplatin;etoposide;ifosfamide;paclitaxel
7 Phase II Trial of Paclitaxel, Ifosfamide, and Cisplatin in Previously Untreated Intermediate and Poor Risk Germ Cell Tumor Patients Completed NCT00470366 Phase 2 cisplatin;ifosfamide;paclitaxel
8 Randomized Phase II Trial of Intensive Induction Chemotherapy (CBOP/BEP) and Standard BEP Chemotherapy in Poor Prognosis Male Germ Cell Tumors Completed NCT00301782 Phase 2 carboplatin;cisplatin;etoposide phosphate;vincristine sulfate
9 Autologous Peripheral Blood Stem Cell Transplant for Germ Cell Tumors Active, not recruiting NCT00432094 Phase 2 carboplatin;etoposide;ifosfamide;paclitaxel;thiotepa;Mesna
10 Pharmacokinetic, Pharmacodynamic and Pharmacogenetic Study of Nab-Paclitaxel (Nanoparticle Albumin Bound-Paclitaxel) in Patients With Advanced Solid Tumors Withdrawn NCT00499291 paclitaxel albumin-stabilized nanoparticle formulation

Search NIH Clinical Center for Adult Teratoma

Genetic Tests for Adult Teratoma

Anatomical Context for Adult Teratoma

MalaCards organs/tissues related to Adult Teratoma:

40
Liver, Thyroid, Ovary, Lung, Testis, Colon, Appendix

Publications for Adult Teratoma

Articles related to Adult Teratoma:

(show all 40)
# Title Authors PMID Year
1
Teratoma Associated With Testicular Tissue in a Female-Like Horse With 64,XY (SRY-Positive) Disorder of Sex Development. 61
32797799 2020
2
[BENIGN OVARIAN PATHOLOGY FINDINGS IN PRE-OPERATIVE AND INTRA-OPERATIVE SIGNS SUGGESTIVE OF MALIGNANCY--CASE SERIES]. 61
26137781 2015
3
[Management of testicular teratoma: update by the Oncology Committee of the French Urology Association, section of External Genital Organs (CCAFU-OGE)]. 61
25199728 2014
4
Conservative treatment of a young patient with thyroid carcinoma in adult ovarian teratoma - case report. 61
24397359 2014
5
Intramedullary cervical teratoma in an adult. 61
19059809 2009
6
[The influence of ovarian tumour histopathological diagnosis on prognostic values of the sonomorphological index]. 61
17076201 2006
7
Cerebral mature teratoma with malignant transformation in a 52-year-old man: a case report. 61
16637568 2006
8
Teratoma or enterogenous cyst? The histopathological and clinical dilemma in co-existing occult neural tube dysraphism. 61
16565928 2006
9
[Testicular teratoma with meningothelial elements]. 61
16323480 2005
10
[The number and histopathologic type of ovarian tumors operated during cesarean section at the Polish Mother's Health Institute between 1990-2000]. 61
12152290 2002
11
Meningeal nodules in teratoma of the testis. 61
11253123 2001
12
Long-term results following adjuvant chemotherapy in patients with clinical stage I testicular nonseminomatous malignant germ cell tumors with high risk factors. 61
10081858 1999
13
Intracranial adult teratoma--a case report. 61
8854734 1996
14
[Testicular epidermoid cyst: orchiectomy or enucleation resection?]. 61
8851841 1996
15
Results of postchemotherapy adjunctive retroperitoneal lymph node dissection in non-seminomatous germ cell cancer patients. 61
8961487 1996
16
[Differentiated teratoma as late recurrence of metastatic non-seminomatous testicular germ cell tumor. Case report and clinical problems]. 61
8848861 1995
17
Organ preserving surgery in testicular epidermoid cysts. 61
7869484 1995
18
[Metastatic adult teratoma of the testis. Possibilities of chemotherapy and surgical treatment]. 61
8178409 1994
19
Size and status of metastases after inductive chemotherapy of germ-cell tumors. Indication for salvage operation. 61
7820141 1994
20
[Ovarian neoplasms in teenagers]. 61
8375703 1993
21
[The synchronous appearance of multiple testicular epidermoid cysts and of a malignant mixed germinal tumor in the contralateral testis]. 61
1314002 1992
22
Differentiated teratoma of testis metastasizing as differentiated teratoma in adult. 61
2728152 1989
23
Testicular germ cell tumors in HLA-genotype non-twin brothers. 61
3176220 1988
24
Combination chemotherapy including VP-16 for poor prognosis germ cell neoplasms. 61
2452507 1988
25
Bulky germinal tumors: comparison of different induction regimens and significance of residual disease. 61
2411564 1985
26
Teratoma of the testis in a pubertal child. 61
3964864 1985
27
[Adult teratoma of the fetal membranes]. 61
7182267 1982
28
Combined chemotherapy and surgery in treatment of advanced germ-cell tumors. 61
7226117 1981
29
[Gliomatosis peritonei--a contribution to the biology of metastasising (author's transl)]. 61
7409434 1980
30
[Adult teratoma of testicular and inguinal localization (author's transl)]. 61
233448 1979
31
A teratoma of the third ventricle of the brain. 61
517204 1979
32
Letter to the editor: Adult teratoma of the testis metastasizing as adult teratoma: case report and review of literature. 61
1255903 1976
33
[Malignant stem-cell tumor of the pineal region with unusual differentiation (author's transl)]. 61
1014967 1976
34
[About a rare teratoma of the pineal region (author's transl)]. 61
1274485 1976
35
Adult teratoma of the testis metastasizing as adult teratoma: case report and review of literature. 61
1235398 1975
36
[Rare case of an adult teratoma of the stomach (author's transl)]. 61
1223971 1975
37
Development of a testicular tumour during cisclomiphene therapy. 61
4742918 1973
38
ADULT TERATOMA OF THE GASSERIAN REGION. 61
14306221 1965
39
Adult teratoma of the testicle metastasizing as adult teratoma. 61
14007839 1962
40
Cystic adult teratoma of the testis associated with failure of the urogenital union. 61
13122928 1954

Variations for Adult Teratoma

Expression for Adult Teratoma

Search GEO for disease gene expression data for Adult Teratoma.

Pathways for Adult Teratoma

GO Terms for Adult Teratoma

Biological processes related to Adult Teratoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 bone development GO:0060348 9.32 FGFR2 ENG
2 epithelial to mesenchymal transition GO:0001837 9.26 FGFR2 ENG
3 embryonic organ development GO:0048568 9.16 TP53 FGFR2
4 angiogenesis GO:0001525 9.13 FGFR2 ENG BSG
5 outflow tract septum morphogenesis GO:0003148 8.62 FGFR2 ENG

Sources for Adult Teratoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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