MCID: ADL057
MIFTS: 25

Adult Teratoma

Categories: Cancer diseases, Fetal diseases

Aliases & Classifications for Adult Teratoma

MalaCards integrated aliases for Adult Teratoma:

Name: Adult Teratoma 12 15 74

Classifications:



External Ids:

Disease Ontology 12 DOID:5565
NCIt 51 C9013
SNOMED-CT 69 42717009
UMLS 74 C1368898

Summaries for Adult Teratoma

Disease Ontology : 12 A teratoma that is present in an adult.

MalaCards based summary : Adult Teratoma is related to teratoma and sclerosing hepatic carcinoma. An important gene associated with Adult Teratoma is AFP (Alpha Fetoprotein). The drugs Ifosfamide and Carboplatin have been mentioned in the context of this disorder. Affiliated tissues include bone, brain and bone marrow, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Related Diseases for Adult Teratoma

Diseases in the Teratoma family:

Malignant Teratoma Adult Teratoma
Intermediate Malignant Teratoma

Diseases related to Adult Teratoma via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 teratoma 10.2
2 sclerosing hepatic carcinoma 9.8 AFP CHGA
3 pancreatic acinar cell adenocarcinoma 9.8 AFP CHGA
4 liver sarcoma 9.8 AFP CHGA
5 pancreatoblastoma 9.8 AFP CHGA
6 endodermal sinus tumor 9.7 AFP CHGA
7 acinar cell carcinoma 9.7 AFP CHGA
8 tubular adenocarcinoma 9.7 AFP CHGA
9 endocrine gland cancer 9.6 AFP CHGA
10 gastric adenocarcinoma 9.5 AFP CHGA

Graphical network of the top 20 diseases related to Adult Teratoma:



Diseases related to Adult Teratoma

Symptoms & Phenotypes for Adult Teratoma

GenomeRNAi Phenotypes related to Adult Teratoma according to GeneCards Suite gene sharing:

27 (show all 13)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-114 9.47 AFP
2 Increased shRNA abundance (Z-score > 2) GR00366-A-116 9.47 CHGA
3 Increased shRNA abundance (Z-score > 2) GR00366-A-120 9.47 AFP
4 Increased shRNA abundance (Z-score > 2) GR00366-A-123 9.47 CHGA
5 Increased shRNA abundance (Z-score > 2) GR00366-A-174 9.47 CHGA
6 Increased shRNA abundance (Z-score > 2) GR00366-A-176 9.47 CHGA
7 Increased shRNA abundance (Z-score > 2) GR00366-A-182 9.47 CHGA
8 Increased shRNA abundance (Z-score > 2) GR00366-A-192 9.47 AFP
9 Increased shRNA abundance (Z-score > 2) GR00366-A-215 9.47 CHGA
10 Increased shRNA abundance (Z-score > 2) GR00366-A-29 9.47 AFP
11 Increased shRNA abundance (Z-score > 2) GR00366-A-63 9.47 AFP
12 Increased shRNA abundance (Z-score > 2) GR00366-A-65 9.47 AFP CHGA
13 Increased shRNA abundance (Z-score > 2) GR00366-A-70 9.47 CHGA

Drugs & Therapeutics for Adult Teratoma

Drugs for Adult Teratoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 179)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ifosfamide Approved Phase 4,Phase 3,Phase 2,Phase 1 3778-73-2 3690
2
Carboplatin Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 41575-94-4 10339178 38904 498142
3
Mechlorethamine Approved, Investigational Phase 4,Phase 3,Phase 1,Phase 2 51-75-2 4033
4
Etoposide Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 33419-42-0 36462
5
Cisplatin Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 15663-27-1 2767 441203 84093
6 Antineoplastic Agents, Alkylating Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
7 Antineoplastic Agents, Phytogenic Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
8 Topoisomerase Inhibitors Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
9 Alkylating Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
10
Isophosphamide mustard Phase 4,Phase 3,Phase 2,Phase 1 0
11 Etoposide phosphate Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
12
Bleomycin Approved, Investigational Phase 3,Phase 2,Not Applicable 11056-06-7 5360373
13
Paclitaxel Approved, Vet_approved Phase 3,Phase 2,Phase 1,Not Applicable 33069-62-4 36314
14
Oxaliplatin Approved, Investigational Phase 3,Phase 2,Phase 1 61825-94-3 43805 6857599 5310940 9887054
15
Lenograstim Approved, Investigational Phase 2, Phase 3,Phase 3,Phase 1,Not Applicable 135968-09-1
16
Vinblastine Approved Phase 3 865-21-4 241903 13342
17
Dexamethasone Approved, Investigational, Vet_approved Phase 3,Phase 2,Phase 1 50-02-2 5743
18
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 3,Phase 2,Phase 1 1177-87-3
19
Mesna Approved, Investigational Phase 3,Phase 1,Phase 2,Not Applicable 3375-50-6 598
20
Cyclophosphamide Approved, Investigational Phase 3,Phase 2,Phase 1,Not Applicable 50-18-0, 6055-19-2 2907
21
Captopril Approved Phase 3 62571-86-2 44093
22
Ribavirin Approved Phase 3 36791-04-5 37542
23
Palivizumab Approved, Investigational Phase 3 188039-54-5
24
Fluconazole Approved, Investigational Phase 3 86386-73-4 3365
25
Miconazole Approved, Investigational, Vet_approved Phase 3 22916-47-8 4189
26
Itraconazole Approved, Investigational Phase 3 84625-61-6 55283
27
Caspofungin Approved Phase 3 162808-62-0, 179463-17-3 2826718 468682
28
Amphotericin B Approved, Investigational Phase 3 1397-89-3 5280965 14956
29
Ondansetron Approved Phase 3 99614-02-5 4595
30
Granisetron Approved, Investigational Phase 3 109889-09-0 3510
31
Vincristine Approved, Investigational Phase 3,Phase 2,Phase 1 2068-78-2, 57-22-7 5978
32
Promethazine Approved, Investigational Phase 3 60-87-7 4927
33
Diphenhydramine Approved, Investigational Phase 3 147-24-0, 58-73-1 3100
34 Antimitotic Agents Phase 3,Phase 2,Phase 1,Not Applicable
35 Anti-Bacterial Agents Phase 3,Phase 2,Phase 1,Not Applicable
36 Albumin-Bound Paclitaxel Phase 3,Phase 2,Phase 1,Not Applicable
37 Antibiotics, Antitubercular Phase 3,Phase 2,Phase 1,Not Applicable
38 Immunologic Factors Phase 3,Phase 1,Phase 2,Not Applicable
39 Immunosuppressive Agents Phase 3,Phase 1,Phase 2,Not Applicable
40 Antiviral Agents Phase 3,Phase 1,Phase 2
41 Anti-Infective Agents Phase 3,Phase 1,Phase 2
42 Antimetabolites Phase 3,Phase 1,Phase 2
43 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3,Phase 2,Phase 1
44 Hormone Antagonists Phase 3,Phase 2,Phase 1
45 Hormones Phase 3,Phase 2,Phase 1
46 Gastrointestinal Agents Phase 3,Phase 2,Phase 1
47 Antiemetics Phase 3,Phase 2,Phase 1
48 BB 1101 Phase 3,Phase 2,Phase 1
49 Peripheral Nervous System Agents Phase 3,Phase 2,Phase 1
50 Autonomic Agents Phase 3,Phase 2,Phase 1

Interventional clinical trials:

(show top 50) (show all 107)
# Name Status NCT ID Phase Drugs
1 Prospective Trial for the Diagnosis and Treatment of Intracranial Germ Cell Tumors Unknown status NCT01424839 Phase 4 Carboplatin, Etoposide, Ifosfamide;Cisplatin, etoposide, Ifosfamide (standard);Cisplatin, Etoposide, Ifosfamide (high dose)
2 Combination Chemotherapy in Treating Patients With Stage II or Stage III Germ Cell Tumors Unknown status NCT00104676 Phase 3 cisplatin;etoposide;ifosfamide;oxaliplatin;paclitaxel
3 Combination Chemotherapy in Treating Men With Germ Cell Cancer Unknown status NCT00003643 Phase 2, Phase 3 cisplatin;etoposide;paclitaxel
4 Safety and Efficacy of Antiadhesive Barrier GUARDIX-FL for Women After Laparoscopic Cystectomy Unknown status NCT02097446 Phase 3
5 Observation and/or Combination Chemotherapy After Surgery or Biopsy in Treating Young Patients With Extracranial Germ Cell Tumors Unknown status NCT00274950 Phase 3 carboplatin;cisplatin;etoposide;ifosfamide;vinblastine sulfate
6 Surgery and Combination Chemotherapy in Treating Children With Extracranial Germ Cell Tumors Completed NCT00053352 Phase 3 cisplatin;etoposide
7 Combination Chemotherapy With or Without Bone Marrow or Stem Cell Transplantation in Treating Men With Untreated Germ Cell Tumors Completed NCT00002596 Phase 3 carboplatin;cisplatin;cyclophosphamide;etoposide
8 Captopril in Treating Patients Undergoing Bone Marrow or Stem Cell Transplantation Completed NCT00004230 Phase 3 captopril;cyclophosphamide
9 Ribavirin With or Without Monoclonal Antibody Therapy in Treating Patients Who Develop RSV Pneumonia Following Peripheral Stem Cell Transplantation Completed NCT00014391 Phase 3 ribavirin
10 Itraconazole Compared With Fluconazole to Prevent Infections in Patients Undergoing Peripheral Stem Cell or Bone Marrow Transplantation Completed NCT00003883 Phase 3 fluconazole;itraconazole
11 Caspofungin Acetate Compared With Amphotericin B Liposomal in Treating Patients With Persistent Fever and Neutropenia Following Cancer Treatment Completed NCT00008359 Phase 3 caspofungin acetate;liposomal amphotericin B
12 Liposomal Amphotericin B in Treating Granulocytopenia and Persistent Unexplained Fever in Cancer Patients Completed NCT00003938 Phase 3 liposomal amphotericin B
13 Combination Chemotherapy With or Without Peripheral Stem Cell Transplant in Treating Men With Previously Untreated Germ Cell Cancer Completed NCT00003941 Phase 3 cisplatin;etoposide;ifosfamide
14 Sodium Thiosulfate in Preventing Hearing Loss in Young Patients Receiving Cisplatin for Newly Diagnosed Germ Cell Tumor, Hepatoblastoma, Medulloblastoma, Neuroblastoma, Osteosarcoma, or Other Malignancy Completed NCT00716976 Phase 3 sodium thiosulfate
15 Acupressure in Controlling Nausea in Young Patients Receiving Highly Emetogenic Chemotherapy Completed NCT01346267 Phase 3
16 Single-port LC Might be Preferable for Managing Ovarian Dermoid Cyst. Completed NCT02009228 Phase 3
17 Active Surveillance, Bleomycin, Carboplatin, Etoposide, or Cisplatin in Treating Pediatric and Adult Patients With Germ Cell Tumors Recruiting NCT03067181 Phase 3 Bleomycin;Carboplatin;Cisplatin;Etoposide;Etoposide Phosphate
18 Standard-Dose Combination Chemotherapy or High-Dose Combination Chemotherapy and Stem Cell Transplant in Treating Patients With Relapsed or Refractory Germ Cell Tumors Recruiting NCT02375204 Phase 3 paclitaxel;ifosfamide;cisplatin;pegylated G-CSF;G-CSF;carboplatin;etoposide phosphate
19 Treatment of Patients With Newly Diagnosed Medulloblastoma, Supratentorial Primitive Neuroectodermal Tumor, or Atypical Teratoid Rhabdoid Tumor Active, not recruiting NCT00085202 Phase 3 cisplatin;cyclophosphamide;vincristine
20 Cisplatin and Ifosfamide Combined With Either Paclitaxel or Vinblastine in Treating Men With Progressive or Recurrent Metastatic Germ Cell Tumors Terminated NCT00072215 Phase 3 cisplatin;ifosfamide;paclitaxel;vinblastine
21 High-Dose Chemotherapy and Stem Cell Transplant in Treating Patients With Metastatic Germ Cell Tumors That Have Not Responded to First-Line Therapy Unknown status NCT01172912 Phase 2 carboplatin;cisplatin;dexamethasone;etoposide;ifosfamide
22 Gemcitabine, Paclitaxel, Ifosfamide, and Cisplatin in Treating Patients With Progressive or Relapsed Metastatic Germ Cell Tumors Unknown status NCT00551122 Phase 1, Phase 2 cisplatin;gemcitabine hydrochloride;ifosfamide;paclitaxel
23 A Randomized, Blinded, Placebo-controlled, Phase II Trial of LEE011 in Patients With Relapsed, Refractory, Incurable Teratoma With Recent Progression Completed NCT02300987 Phase 2 LEE011;LEE011 Placebo
24 Combination Chemotherapy and Pegfilgrastim in Treating Men With Metastatic Germ Cell Tumors Completed NCT00453232 Phase 2 cisplatin;etoposide
25 Combination Chemotherapy in Treating Male Patients With Germ Cell Tumors Completed NCT00301782 Phase 2 carboplatin;cisplatin;etoposide phosphate;vincristine sulfate
26 Paclitaxel, Ifosfamide, and Carboplatin Followed By Autologous Stem Cell Transplant in Treating Patients With Germ Cell Tumors That Did Not Respond to Cisplatin Completed NCT00423852 Phase 1, Phase 2 carboplatin;ifosfamide;paclitaxel
27 Sunitinib in Treating Patients With Metastatic Germ Cell Tumors That Have Relapsed or Not Responded to Treatment Completed NCT00453310 Phase 2 sunitinib malate
28 Combination Chemotherapy and Pegfilgrastim in Treating Patients With Previously Untreated Germ Cell Tumors Completed NCT00470366 Phase 2 cisplatin;ifosfamide;paclitaxel
29 Combination Chemotherapy Plus Peripheral Stem Cell Transplantation in Treating Patients With Relapsed Germ Cell Cancer Completed NCT00002931 Phase 2 carboplatin;etoposide;ifosfamide;paclitaxel
30 Oxaliplatin in Treating Young Patients With Recurrent Solid Tumors That Have Not Responded to Previous Treatment Completed NCT00091182 Phase 2 oxaliplatin
31 Combination Chemotherapy in Treating Children With Non-testicular Malignant Germ Cell Tumors Completed NCT00002489 Phase 2 carboplatin;cyclophosphamide;doxorubicin hydrochloride;etoposide;leucovorin calcium;methotrexate;vincristine sulfate
32 Immunotherapy in Treating Patients Who Are Undergoing Bone Marrow or Peripheral Stem Cell Transplantation Completed NCT00002673 Phase 2
33 Lymphocyte Infusion in Treating Patients With Relapsed Cancer After Bone Marrow or Peripheral Stem Cell Transplantation Completed NCT00003887 Phase 2
34 Beclomethasone in Treating Patients With Graft-Versus-Host Disease of the Esophagus, Stomach, Small Intestine, or Colon Completed NCT00010283 Phase 1, Phase 2 beclomethasone dipropionate
35 Interleukin-11 Plus Filgrastim Prior to Peripheral Stem Cell Transplantation in Patients With Non-Hodgkin's Lymphoma, Hodgkin's Disease, Breast Cancer, or Other Solid Tumors Completed NCT00004157 Phase 2
36 Biological Therapy Following Chemotherapy and Peripheral Stem Cell Transplantation in Treating Patients With Cancer Completed NCT00003408 Phase 2
37 Ixabepilone in Treating Patients With Advanced Cisplatin-Refractory Germ Cell Tumors Completed NCT00070096 Phase 2 ixabepilone
38 Paclitaxel, Ifosfamide, and Cisplatin in Treating Patients With Metastatic Testicular Cancer Completed NCT00004077 Phase 2 cisplatin;ifosfamide;paclitaxel
39 Neoadjuvant Chemotherapy With or Without Second-Look Surgery Followed by Radiation Therapy With or Without Peripheral Stem Cell Transplantation in Treating Patients With Intracranial Germ Cell Tumors Completed NCT00047320 Phase 2 carboplatin;etoposide;ifosfamide;thiotepa
40 Cisplatin and Etoposide Prior to Radiation Therapy in Treating Patients With CNS Tumors Completed NCT00002472 Phase 2 cisplatin;etoposide
41 Combination Chemotherapy Plus Amifostine in Treating Children With Malignant Germ Cell Tumors Completed NCT00003811 Phase 2 amifostine trihydrate;cisplatin;etoposide
42 High-Dose Thiotepa Plus Peripheral Stem Cell Transplantation in Treating Patients With Refractory Solid Tumors Completed NCT00003173 Phase 2 thiotepa
43 Arsenic Trioxide in Treating Patients With Advanced Neuroblastoma or Other Childhood Solid Tumors Completed NCT00024258 Phase 2 arsenic trioxide
44 Temozolomide Followed by Radiation Therapy in Treating Children With Newly Diagnosed Malignant CNS Tumors Completed NCT00005955 Phase 2 temozolomide
45 Oxaliplatin in Treating Children With Recurrent or Refractory Medulloblastoma, Supratentorial Primitive Neuroectodermal Tumor, or Atypical Teratoid Rhabdoid Tumor Completed NCT00047177 Phase 2 Oxaliplatin
46 Autologous Peripheral Blood Stem Cell Transplant for Germ Cell Tumors Recruiting NCT00432094 Phase 2 carboplatin;etoposide;ifosfamide;paclitaxel;thiotepa;Mesna
47 Contribution of the Imaging to the Expression of intégrines αvβ3 for the Characterization of Residual Masses of Non-seminoma Tumors at the End of Chemotherapy Recruiting NCT02317393 Phase 2
48 Nivolumab and Ipilimumab in Treating Patients With Rare Tumors Recruiting NCT02834013 Phase 2
49 PHASE II TRIAL OF THE CYCLIN-DEPEDENT KINASE INHIBITOR PD 0332991 IN PATIENTS WITH CANCER Recruiting NCT01037790 Phase 2 PD-0332991
50 Phase 2 Study of Alisertib Therapy for Rhabdoid Tumors Recruiting NCT02114229 Phase 2 alisertib;methotrexate;cisplatin;carboplatin;cyclophosphamide;etoposide;topotecan;vincristine

Search NIH Clinical Center for Adult Teratoma

Genetic Tests for Adult Teratoma

Anatomical Context for Adult Teratoma

MalaCards organs/tissues related to Adult Teratoma:

42
Bone, Brain, Bone Marrow, Spinal Cord, Thyroid, Small Intestine, Colon

Publications for Adult Teratoma

Articles related to Adult Teratoma:

# Title Authors Year
1
Intracranial adult teratoma--a case report. ( 8854734 )
1996
2
Letter to the editor: Adult teratoma of the testis metastasizing as adult teratoma: case report and review of literature. ( 1255903 )
1976
3
Adult teratoma of the testis metastasizing as adult teratoma: case report and review of literature. ( 1235398 )
1975
4
ADULT TERATOMA OF THE GASSERIAN REGION. ( 14306221 )
1965
5
Adult teratoma of the testicle metastasizing as adult teratoma. ( 14007839 )
1962
6
Cystic adult teratoma of the testis associated with failure of the urogenital union. ( 13122928 )
1954

Variations for Adult Teratoma

Expression for Adult Teratoma

Search GEO for disease gene expression data for Adult Teratoma.

Pathways for Adult Teratoma

GO Terms for Adult Teratoma

Sources for Adult Teratoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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