MCID: ADL037
MIFTS: 28

Adult Xanthogranuloma

Categories: Bone diseases, Immune diseases, Rare diseases, Skin diseases

Aliases & Classifications for Adult Xanthogranuloma

MalaCards integrated aliases for Adult Xanthogranuloma:

Name: Adult Xanthogranuloma 12 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:7875
NCIt 50 C27514
UMLS 73 C1332220

Summaries for Adult Xanthogranuloma

MalaCards based summary : Adult Xanthogranuloma is related to necrobiotic xanthogranuloma and non-langerhans-cell histiocytosis. An important gene associated with Adult Xanthogranuloma is CD163 (CD163 Molecule), and among its related pathways/superpathways are C-MYB transcription factor network and Dendritic Cells Developmental Lineage Pathway. Affiliated tissues include skin, bone and liver, and related phenotypes are hematopoietic system and immune system

Related Diseases for Adult Xanthogranuloma

Diseases in the Adult Xanthogranuloma family:

Juvenile Xanthogranuloma

Diseases related to Adult Xanthogranuloma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 69)
# Related Disease Score Top Affiliating Genes
1 necrobiotic xanthogranuloma 11.2
2 non-langerhans-cell histiocytosis 10.2 CD163 LYZ
3 histiocytic and dendritic cell cancer 10.1 CD163 LYZ
4 congenital granular cell tumor 10.1 LYZ SERPINA1
5 synovitis 10.1 CD163 CD68
6 lymphoplasmacyte-rich meningioma 10.1 CD163 CD68
7 petroclival meningioma 10.1 CD163 CD68
8 cardiomyopathy, infantile histiocytoid 10.1 CD68 LYZ
9 malignant giant cell tumor of soft parts 10.1 CD68 LYZ
10 cutaneous solitary mastocytoma 10.1 LYZ SERPINA1
11 photokeratitis 10.1 CD163 CD68
12 liver sarcoma 10.1 CD68 LYZ
13 phacolytic glaucoma 10.1 CD68 SERPINA1
14 granulomatous myositis 10.1 CD68 LYZ
15 parasitic ichthyosporea infectious disease 10.1 CD68 SERPINA1
16 rhinosporidiosis 10.1 CD68 SERPINA1
17 trigeminal nerve neoplasm 10.1 CD68 LYZ
18 inflammatory mfh 10.1 CD68 SERPINA1
19 neurilemmoma of the fifth cranial nerve 10.1 CD68 LYZ
20 rhinoscleroma 10.1 CD68 SERPINA1
21 retinitis pigmentosa 7 10.1 LYZ SERPINA1
22 nodular tenosynovitis 10.1 CD68 S100A9
23 acute salpingitis 10.1 CD68 LYZ
24 enterobiasis 10.1 CD163 CD68
25 ulcerative stomatitis 10.1 CD68 LYZ
26 clear cell acanthoma 10.1 CD68 HAVCR1
27 xanthogranulomatous pyelonephritis 10.1 CD68 LYZ
28 diffuse meningeal melanocytosis 10.1 CD68 S100A9
29 malignant fibroxanthoma 10.1 LYZ SERPINA1
30 dermis tumor 10.0 CD163 HAVCR1 LYZ
31 retinal hemangioblastoma 10.0 LYZ S100A9
32 granulomatous gastritis 10.0 CD68 FUT4
33 nodular nonsuppurative panniculitis 10.0 LYZ SERPINA1
34 hodgkin's lymphoma, lymphocytic depletion 10.0 CD68 FUT4
35 central nervous system sarcoma 10.0 CD163 CD68 LYZ
36 infiltrating lipoma 10.0 CD163 CD34
37 lymphatic system disease 10.0 CD68 LYZ
38 central nervous system melanocytic neoplasm 10.0 CD68 S100A9
39 urinary system disease 10.0 HAVCR1 LYZ
40 retina lymphoma 10.0 CD34 CD68
41 extracutaneous mastocytoma 10.0 CD34 CD68
42 glomeruloid hemangioma 9.9 CD34 CD68
43 hemangioma of liver 9.9 CD34 CD68
44 in situ pulmonary adenocarcinoma 9.9 LYZ S100A9 SERPINA1
45 conventional fibrosarcoma 9.9 CD34 CD68
46 mixed liposarcoma 9.9 CD34 CD68
47 xanthogranulomatous cholecystitis 9.9 CD68 LYZ S100A9
48 ischemic fasciitis 9.9 CD34 CD68
49 lymphangiosarcoma 9.9 CD34 LYZ
50 sarcomatoid squamous cell skin carcinoma 9.9 CD34 CD68

Graphical network of the top 20 diseases related to Adult Xanthogranuloma:



Diseases related to Adult Xanthogranuloma

Symptoms & Phenotypes for Adult Xanthogranuloma

MGI Mouse Phenotypes related to Adult Xanthogranuloma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.43 CD163 CD34 CD68 FUT4 LYZ S100A9
2 immune system MP:0005387 9.1 CD163 CD34 CD68 FUT4 LYZ S100A9

Drugs & Therapeutics for Adult Xanthogranuloma

Search Clinical Trials , NIH Clinical Center for Adult Xanthogranuloma

Genetic Tests for Adult Xanthogranuloma

Anatomical Context for Adult Xanthogranuloma

MalaCards organs/tissues related to Adult Xanthogranuloma:

41
Skin, Bone, Liver, Spleen, Retina

Publications for Adult Xanthogranuloma

Articles related to Adult Xanthogranuloma:

(show all 14)
# Title Authors Year
1
Cutaneous adult xanthogranuloma with a small portion of BRAFV600E mutated Langerhans cell histiocytosis populations: A case report and the review of published work. ( 30536719 )
2018
2
Adult xanthogranuloma diagnosed on reflectance confocal microscopy. ( 28671710 )
2017
3
Multiple CD163(+) adult xanthogranuloma associated with myelodysplastic syndrome. ( 26249658 )
2015
4
Adult Xanthogranuloma, Reticulohistiocytosis, and Rosai-Dorfman Disease. ( 26143426 )
2015
5
Unusual presentation of adult xanthogranuloma: a case report. ( 24154556 )
2013
6
CD163+ adult xanthogranuloma arising from Merkel cell carcinoma treated with local radiotherapy. ( 22504842 )
2012
7
Adult xanthogranuloma mimicking basal cell carcinoma: dermoscopy, reflectance confocal microscopy and pathological correlation. ( 19996569 )
2010
8
Adult xanthogranuloma causing nasal obstruction. ( 20479384 )
2010
9
Multiple adult xanthogranuloma in intertriginous areas. ( 19335696 )
2009
10
Multiple adult xanthogranuloma: case report and literature review. ( 16319479 )
2006
11
Ossifying adult xanthogranuloma. ( 14521441 )
2003
12
Adult xanthogranuloma of the vulva: case report and review. ( 11902455 )
2002
13
Juvenile and adult xanthogranuloma. A histological and immunohistochemical comparison. ( 8291651 )
1994
14
Solitary adult xanthogranuloma: a case report with new observation on lipid droplet formation. ( 6162331 )
1980

Variations for Adult Xanthogranuloma

Expression for Adult Xanthogranuloma

Search GEO for disease gene expression data for Adult Xanthogranuloma.

Pathways for Adult Xanthogranuloma

Pathways related to Adult Xanthogranuloma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.15 CD34 LYZ
2 11.02 CD163 CD34
3 10.86 CD163 CD34 CD68
4 10.81 CD163 CD68

GO Terms for Adult Xanthogranuloma

Cellular components related to Adult Xanthogranuloma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.35 CD163 CD34 LYZ S100A9 SERPINA1
2 cell periphery GO:0071944 8.62 CD34 FUT4

Biological processes related to Adult Xanthogranuloma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 inflammatory response GO:0006954 9.43 CD163 LYZ S100A9
2 antimicrobial humoral response GO:0019730 9.16 LYZ S100A9
3 acute-phase response GO:0006953 8.96 CD163 SERPINA1
4 neutrophil degranulation GO:0043312 8.92 CD68 LYZ S100A9 SERPINA1

Sources for Adult Xanthogranuloma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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