MCID: ADL037
MIFTS: 31

Adult Xanthogranuloma

Categories: Bone diseases, Immune diseases, Rare diseases, Skin diseases

Aliases & Classifications for Adult Xanthogranuloma

MalaCards integrated aliases for Adult Xanthogranuloma:

Name: Adult Xanthogranuloma 12 15 70

Classifications:



External Ids:

Disease Ontology 12 DOID:7875
NCIt 50 C27514
UMLS 70 C1332220

Summaries for Adult Xanthogranuloma

MalaCards based summary : Adult Xanthogranuloma is related to juvenile xanthogranuloma and histiocytosis. An important gene associated with Adult Xanthogranuloma is CD163 (CD163 Molecule), and among its related pathways/superpathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. Affiliated tissues include skin, liver and bone, and related phenotypes are hematopoietic system and immune system

Related Diseases for Adult Xanthogranuloma

Diseases in the Adult Xanthogranuloma family:

Juvenile Xanthogranuloma

Diseases related to Adult Xanthogranuloma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 213)
# Related Disease Score Top Affiliating Genes
1 juvenile xanthogranuloma 30.7 SERPINA3 CD1E CD1A
2 histiocytosis 30.4 SERPINA3 CD207 CD1C CD1A CD163
3 langerhans cell histiocytosis 30.3 CD68 CD207 CD1C CD1A CD163
4 multicentric reticulohistiocytosis 30.2 SERPINA3 CD68 CD1E
5 rosai-dorfman disease 29.9 CR2 CD163
6 cutaneous fibrous histiocytoma 29.8 SERPINA3 HAVCR1 CD68 CD34
7 fibrous histiocytoma 29.5 SERPINA3 MITF CD68 CD34 CD163
8 non-langerhans-cell histiocytosis 29.5 SERPINA3 CD68 CD207 CD1E CD1D CD1C
9 predominantly cortical thymoma 10.4 CD1E CD1A
10 histiocytic sarcoma 10.4 CD68 CD163
11 tolosa-hunt syndrome 10.4 CD1E CD1A
12 cavernous sinus meningioma 10.4 CD207 CD163
13 congenital epulis 10.4 SERPINA3 CD68
14 epulis 10.4 SERPINA3 CD68
15 verruciform xanthoma of skin 10.4 SERPINA3 CD68
16 multifocal motor neuropathy 10.4 CD1E CD1A
17 alk+ histiocytosis 10.4 CD207 CD1A
18 proliferative fasciitis 10.4 SERPINA3 CD68
19 pancreas sarcoma 10.4 SERPINA3 CD68
20 granulomatous orchitis 10.4 CD68 CD1E
21 xanthogranulomatous pyelonephritis 10.4 SERPINA3 CD68
22 malignant granular cell myoblastoma 10.3 SERPINA3 CD68
23 xanthogranulomatous cholecystitis 10.3 SERPINA3 CD68
24 mixed type thymoma 10.3 CD1E CD1B CD1A
25 encapsulated thymoma 10.3 CD1E CD1B CD1A
26 sphenoid sinusitis 10.3 CD1E CD1B CD1A
27 epithelial malignant thymoma 10.3 CD1E CD1B CD1A
28 lung sarcoma 10.3 SERPINA3 CD34
29 retroperitoneal hemangiopericytoma 10.3 CD68 CD34
30 breast leiomyosarcoma 10.3 CD68 CD34
31 breast malignant phyllodes tumor 10.3 SERPINA3 CD34
32 pityriasis rosea 10.3 CD1E CD1A
33 skin sarcoma 10.3 CD68 CD34
34 pulmonary artery leiomyosarcoma 10.3 CD68 CD34
35 malignant mesenchymoma 10.2 SERPINA3 CD34
36 kimura disease 10.2 CD1E CD1A
37 cutaneous leiomyosarcoma 10.2 CD68 CD34
38 malignant inflammatory fibrous histiocytoma 10.2 SERPINA3 S100A9 CD68
39 intravascular fasciitis 10.2 CD68 CD34
40 glomeruloid hemangioma 10.2 CD68 CD34
41 extraosseous osteosarcoma 10.2 CD68 CD34
42 peripheral nerve schwannoma 10.2 SERPINA3 NF1
43 myofibroma 10.2 SERPINA3 CD34 CD1A
44 liver sarcoma 10.2 SERPINA3 SERPINA1 CD68
45 sarcomatoid squamous cell skin carcinoma 10.2 SERPINA3 CD68 CD34
46 ischemic fasciitis 10.2 CD68 CD34 CD163
47 pleomorphic lipoma 10.2 SERPINA3 CD68 CD34
48 pleural lipoma 10.2 SERPINA1 FUT4
49 bladder sarcoma 10.2 SERPINA3 CD68 CD34
50 bone benign neoplasm 10.2 SERPINA3 CD68 CD34

Graphical network of the top 20 diseases related to Adult Xanthogranuloma:



Diseases related to Adult Xanthogranuloma

Symptoms & Phenotypes for Adult Xanthogranuloma

MGI Mouse Phenotypes related to Adult Xanthogranuloma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.7 CD163 CD1D CD207 CD34 CD4 CD68
2 immune system MP:0005387 9.36 CD163 CD1D CD207 CD34 CD4 CD68

Drugs & Therapeutics for Adult Xanthogranuloma

Search Clinical Trials , NIH Clinical Center for Adult Xanthogranuloma

Genetic Tests for Adult Xanthogranuloma

Anatomical Context for Adult Xanthogranuloma

MalaCards organs/tissues related to Adult Xanthogranuloma:

40
Skin, Liver, Bone, Thymus, Lung, Breast, Lymph Node

Publications for Adult Xanthogranuloma

Articles related to Adult Xanthogranuloma:

(show all 31)
# Title Authors PMID Year
1
Multiple adult xanthogranuloma with upper airway involvement. 61
33560521 2021
2
Solitary adult xanthogranuloma in external auditory canal: Cyto-histopathological correlation of an uncommon entity at an uncommon site. 61
32275346 2020
3
Multiple adult xanthogranuloma. 61
31883764 2020
4
Adult xanthogranuloma of the iris, an unusual isolated location. 61
31221452 2019
5
Successful treatment of multiple eruptive adult xanthogranuloma concomitant with xanthelasma palpebrarum with probucol. 61
31050040 2019
6
Cutaneous adult xanthogranuloma with a small portion of BRAFV600E mutated Langerhans cell histiocytosis populations: A case report and the review of published work. 61
30536719 2019
7
Adult xanthogranuloma diagnosed on reflectance confocal microscopy. 61
28671710 2017
8
Multiple CD163(+) adult xanthogranuloma associated with myelodysplastic syndrome. 61
26249658 2015
9
Adult Xanthogranuloma, Reticulohistiocytosis, and Rosai-Dorfman Disease. 61
26143426 2015
10
Unusual presentation of adult xanthogranuloma: a case report. 61
24154556 2014
11
[Adult xanthogranuloma at the base of the nose]. 61
24315236 2013
12
[Adult xanthogranuloma]. 61
24034647 2013
13
CD163+ adult xanthogranuloma arising from Merkel cell carcinoma treated with local radiotherapy. 61
22504842 2012
14
Adult xanthogranuloma causing nasal obstruction. 61
20479384 2010
15
Multiple periocular adult onset xanthogranulomas in a patient with chronic lymphocytic leukaemia. 61
19919911 2010
16
Adult xanthogranuloma mimicking basal cell carcinoma: dermoscopy, reflectance confocal microscopy and pathological correlation. 61
19996569 2010
17
Multiple adult xanthogranuloma in intertriginous areas. 61
19335696 2009
18
Adult xanthogranulomatous disease of the orbit and ocular adnexa: new immunohistochemical findings and clinical review. 61
16622091 2006
19
Multiple adult xanthogranuloma: case report and literature review. 61
16319479 2006
20
Mammary presentation of adult-type "juvenile" xanthogranuloma. 61
15897751 2005
21
[Multiple adult xanthogranuloma]. 61
16476360 2005
22
Ossifying adult xanthogranuloma. 61
14521441 2003
23
Adult xanthogranuloma of the vulva: case report and review. 61
11902455 2002
24
[Bilateral adult periocular xanthogranuloma]. 61
9527593 1997
25
Reticulohistiocytoma and multicentric reticulohistiocytosis. Histopathologic and immunophenotypic distinct entities. 61
7864294 1994
26
A case of fibrous histiocytoma associated with xanthogranulomatous alteration. 61
8056904 1994
27
Juvenile and adult xanthogranuloma. A histological and immunohistochemical comparison. 61
8291651 1994
28
[Solitary reticulohistiocytic granuloma--a report of three cases and a review of literature]. 61
1942582 1991
29
Adult xanthogranulomatous intracranial lesion involving familial hypercholesterolemia. 61
2699337 1989
30
Solitary adult xanthogranuloma: a case report with new observation on lipid droplet formation. 61
6162331 1980
31
Xanthogranuloma in adults. 61
1247291 1976

Variations for Adult Xanthogranuloma

Expression for Adult Xanthogranuloma

Search GEO for disease gene expression data for Adult Xanthogranuloma.

Pathways for Adult Xanthogranuloma

GO Terms for Adult Xanthogranuloma

Cellular components related to Adult Xanthogranuloma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 membrane GO:0016020 10.31 S100A9 NF1 HAVCR1 FUT4 CR2 CR1
2 plasma membrane GO:0005886 10.26 S100A9 CR2 CR1 CD68 CD4 CD34
3 extracellular space GO:0005615 10.06 SERPINA3 SERPINA1 S100A9 CD1E CD1D CD1C
4 integral component of membrane GO:0016021 10.03 NF1 HAVCR1 FUT4 CR2 CR1 CD68
5 integral component of plasma membrane GO:0005887 9.97 CR1 CD4 CD34 CD1E CD1D CD1C
6 endosome GO:0005768 9.91 CD68 CD1E CD1D CD1C CD1B CD1A
7 lysosome GO:0005764 9.73 CD68 CD34 CD1E CD1D CD1C CD1B
8 endosome membrane GO:0010008 9.72 CD68 CD1D CD1C CD1B CD1A
9 cell surface GO:0009986 9.5 HAVCR1 FUT4 CR1 CD4 CD34 CD1D
10 external side of plasma membrane GO:0009897 9.23 CD4 CD34 CD1E CD1D CD1C CD1B

Biological processes related to Adult Xanthogranuloma according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 immune system process GO:0002376 9.91 S100A9 CR2 CR1 CD4 CD1E CD1D
2 neutrophil degranulation GO:0043312 9.89 SERPINA3 SERPINA1 S100A9 CR1 CD68
3 adaptive immune response GO:0002250 9.88 CD4 CD1E CD1C CD1B CD1A
4 immune response GO:0006955 9.87 CR2 CD4 CD1E CD1D CD1C CD1B
5 regulation of immune response GO:0050776 9.77 CD34 CD1D CD1C CD1B CD1A
6 viral entry into host cell GO:0046718 9.69 HAVCR1 CR2 CR1
7 acute-phase response GO:0006953 9.61 SERPINA3 SERPINA1 CD163
8 positive regulation of T cell mediated cytotoxicity GO:0001916 9.55 CD1E CD1D CD1C CD1B CD1A
9 complement activation, alternative pathway GO:0006957 9.54 CR2 CR1
10 complement receptor mediated signaling pathway GO:0002430 9.52 CR2 CR1
11 autocrine signaling GO:0035425 9.46 S100A9 CD68
12 T cell selection GO:0045058 9.4 CD4 CD1D
13 antigen processing and presentation, exogenous lipid antigen via MHC class Ib GO:0048007 9.35 CD1E CD1D CD1C CD1B CD1A
14 antigen processing and presentation, endogenous lipid antigen via MHC class Ib GO:0048006 9.02 CD1E CD1D CD1C CD1B CD1A

Molecular functions related to Adult Xanthogranuloma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 virus receptor activity GO:0001618 9.56 HAVCR1 CR2 CR1 CD4
2 lipopeptide binding GO:0071723 9.55 CD1E CD1D CD1C CD1B CD1A
3 exogenous lipid antigen binding GO:0030884 9.35 CD1E CD1D CD1C CD1B CD1A
4 endogenous lipid antigen binding GO:0030883 9.02 CD1E CD1D CD1C CD1B CD1A

Sources for Adult Xanthogranuloma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
Content
Loading form....