MCID: ADL037
MIFTS: 30

Adult Xanthogranuloma

Categories: Bone diseases, Immune diseases, Rare diseases, Skin diseases

Aliases & Classifications for Adult Xanthogranuloma

MalaCards integrated aliases for Adult Xanthogranuloma:

Name: Adult Xanthogranuloma 12 15 74

Classifications:



External Ids:

Disease Ontology 12 DOID:7875
NCIt 51 C27514
UMLS 74 C1332220

Summaries for Adult Xanthogranuloma

MalaCards based summary : Adult Xanthogranuloma is related to langerhans cell histiocytosis and histiocytosis. An important gene associated with Adult Xanthogranuloma is CD163 (CD163 Molecule), and among its related pathways/superpathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. Affiliated tissues include skin, liver and bone, and related phenotype is Synthetic lethal with vaccinia virus (VACV) infection.

Related Diseases for Adult Xanthogranuloma

Diseases in the Adult Xanthogranuloma family:

Juvenile Xanthogranuloma

Diseases related to Adult Xanthogranuloma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 61)
# Related Disease Score Top Affiliating Genes
1 langerhans cell histiocytosis 30.0 CD163 CD1A CD207
2 histiocytosis 30.0 CD163 CD1A CD207
3 necrobiotic xanthogranuloma 11.2
4 cavernous sinus meningioma 10.4 CD163 CD207
5 alk+ histiocytosis 10.4 CD1A CD207
6 non-langerhans-cell histiocytosis 10.3 CD163 CD207
7 dermis tumor 10.3 CD163 HAVCR1
8 histiocytic and dendritic cell cancer 10.3 CD163 CD207
9 multifocal motor neuropathy 10.3 CD1A CD1E
10 langerhans cell sarcoma 10.2 CD163 CD1A CD207
11 central nervous system tuberculosis 10.2 CD163 CD207
12 cholesterol ester storage disease 10.2 CD1A SERPINA1
13 central nervous system sarcoma 10.2 CD163 CD68
14 lymphoplasmacyte-rich meningioma 10.2 CD163 CD68
15 infiltrating lipoma 10.2 CD163 CD34
16 petroclival meningioma 10.2 CD163 CD68
17 phacolytic glaucoma 10.1 CD68 SERPINA1
18 in situ pulmonary adenocarcinoma 10.1 S100A9 SERPINA1
19 parasitic ichthyosporea infectious disease 10.1 CD68 SERPINA1
20 nodular tenosynovitis 10.1 CD68 S100A9
21 rhinosporidiosis 10.1 CD68 SERPINA1
22 inflammatory mfh 10.1 CD68 SERPINA1
23 photokeratitis 10.1 CD163 CD68
24 rhinoscleroma 10.1 CD68 SERPINA1
25 diffuse meningeal melanocytosis 10.1 CD68 S100A9
26 eccrine adenocarcinoma 10.1 CD1C CD34
27 enterobiasis 10.1 CD163 CD68
28 clear cell acanthoma 10.0 CD68 HAVCR1
29 retina lymphoma 10.0 CD34 CD68
30 extracutaneous mastocytoma 10.0 CD34 CD68
31 thymus lipoma 10.0 CD1A CD1B CD1C
32 immune system organ benign neoplasm 10.0 CD1A CD1B CD1C
33 glomeruloid hemangioma 10.0 CD34 CD68
34 hemangioma of liver 10.0 CD34 CD68
35 conventional fibrosarcoma 10.0 CD34 CD68
36 dendritic cell tumor 10.0 CD1A CD207 CD68
37 mixed liposarcoma 10.0 CD34 CD68
38 xanthogranulomatous cholecystitis 10.0 CD68 S100A9
39 ischemic fasciitis 10.0 CD34 CD68
40 lymphatic system disease 9.9 CD207 CD68
41 sarcomatoid squamous cell skin carcinoma 9.9 CD34 CD68
42 central nervous system melanocytic neoplasm 9.9 CD68 S100A9
43 spleen cancer 9.9 CD163 CD34 CD68
44 hepatitis a 9.9 HAVCR1 SERPINA1
45 skin sarcoma 9.9 CD163 CD34 CD68
46 granulomatous gastritis 9.9 CD68 FUT4
47 chorioangioma 9.8 CD34 FUT4
48 erythema elevatum diutinum 9.8 CD34 CD68 S100A9
49 hodgkin's lymphoma, lymphocytic depletion 9.8 CD68 FUT4
50 basal cell carcinoma 1 9.8

Graphical network of the top 20 diseases related to Adult Xanthogranuloma:



Diseases related to Adult Xanthogranuloma

Symptoms & Phenotypes for Adult Xanthogranuloma

GenomeRNAi Phenotypes related to Adult Xanthogranuloma according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with vaccinia virus (VACV) infection GR00362-A 8.92 CD1C CD68 HAVCR1 SERPINA1

Drugs & Therapeutics for Adult Xanthogranuloma

Search Clinical Trials , NIH Clinical Center for Adult Xanthogranuloma

Genetic Tests for Adult Xanthogranuloma

Anatomical Context for Adult Xanthogranuloma

MalaCards organs/tissues related to Adult Xanthogranuloma:

42
Skin, Liver, Bone, Spleen, Thymus, Retina

Publications for Adult Xanthogranuloma

Articles related to Adult Xanthogranuloma:

(show all 15)
# Title Authors Year
1
Cutaneous adult xanthogranuloma with a small portion of BRAFV600E mutated Langerhans cell histiocytosis populations: A case report and the review of published work. ( 30536719 )
2019
2
Successful treatment of multiple eruptive adult xanthogranuloma concomitant with xanthelasma palpebrarum with probucol. ( 31050040 )
2019
3
Adult xanthogranuloma diagnosed on reflectance confocal microscopy. ( 28671710 )
2017
4
Adult Xanthogranuloma, Reticulohistiocytosis, and Rosai-Dorfman Disease. ( 26143426 )
2015
5
Multiple CD163(+) adult xanthogranuloma associated with myelodysplastic syndrome. ( 26249658 )
2015
6
Unusual presentation of adult xanthogranuloma: a case report. ( 24154556 )
2014
7
CD163+ adult xanthogranuloma arising from Merkel cell carcinoma treated with local radiotherapy. ( 22504842 )
2012
8
Adult xanthogranuloma mimicking basal cell carcinoma: dermoscopy, reflectance confocal microscopy and pathological correlation. ( 19996569 )
2010
9
Adult xanthogranuloma causing nasal obstruction. ( 20479384 )
2010
10
Multiple adult xanthogranuloma in intertriginous areas. ( 19335696 )
2009
11
Multiple adult xanthogranuloma: case report and literature review. ( 16319479 )
2006
12
Ossifying adult xanthogranuloma. ( 14521441 )
2003
13
Adult xanthogranuloma of the vulva: case report and review. ( 11902455 )
2002
14
Juvenile and adult xanthogranuloma. A histological and immunohistochemical comparison. ( 8291651 )
1994
15
Solitary adult xanthogranuloma: a case report with new observation on lipid droplet formation. ( 6162331 )
1980

Variations for Adult Xanthogranuloma

Expression for Adult Xanthogranuloma

Search GEO for disease gene expression data for Adult Xanthogranuloma.

Pathways for Adult Xanthogranuloma

GO Terms for Adult Xanthogranuloma

Cellular components related to Adult Xanthogranuloma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integral component of plasma membrane GO:0005887 9.91 CD163 CD1A CD1C CD1D CD1E CD34
2 lysosome GO:0005764 9.65 CD1B CD1C CD1D CD1E CD34
3 endosome GO:0005768 9.63 CD1A CD1B CD1C CD1D CD1E CD68
4 endosome membrane GO:0010008 9.35 CD1A CD1B CD1C CD1D CD68
5 cell surface GO:0009986 8.92 CD1B CD1D CD34 FUT4
6 membrane GO:0016020 10.15 CD163 CD1A CD1B CD1C CD1D CD1E
7 plasma membrane GO:0005886 10.1 CD163 CD1A CD1B CD1C CD1D CD1E
8 integral component of membrane GO:0016021 10.06 CD163 CD1A CD1B CD1C CD1D CD1E

Biological processes related to Adult Xanthogranuloma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 immune system process GO:0002376 9.8 CD1A CD1B CD1C CD1D CD1E S100A9
2 immune response GO:0006955 9.77 CD1A CD1B CD1C CD1D CD1E
3 adaptive immune response GO:0002250 9.71 CD1A CD1B CD1C CD1E
4 regulation of immune response GO:0050776 9.65 CD1A CD1B CD1C CD1D CD34
5 positive regulation of T cell mediated cytotoxicity GO:0001916 9.55 CD1A CD1B CD1C CD1D CD1E
6 acute-phase response GO:0006953 9.43 CD163 SERPINA1
7 antigen processing and presentation, exogenous lipid antigen via MHC class Ib GO:0048007 9.35 CD1A CD1B CD1C CD1D CD1E
8 antigen processing and presentation, endogenous lipid antigen via MHC class Ib GO:0048006 9.02 CD1A CD1B CD1C CD1D CD1E

Molecular functions related to Adult Xanthogranuloma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 lipopeptide binding GO:0071723 9.55 CD1A CD1B CD1C CD1D CD1E
2 endogenous lipid antigen binding GO:0030883 9.35 CD1A CD1B CD1C CD1D CD1E
3 exogenous lipid antigen binding GO:0030884 9.02 CD1A CD1B CD1C CD1D CD1E

Sources for Adult Xanthogranuloma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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