Advanced Sleep Phase Syndrome disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Advanced Sleep Phase Syndrome

MalaCards integrated aliases for Advanced Sleep Phase Syndrome:

Name: Advanced Sleep Phase Syndrome ¹¹ ⁷⁵ ⁵³ ¹⁴ ⁷¹

Fasps ¹⁹ ⁵⁸ ⁵³

Familial Advanced Sleep-Phase Syndrome ¹¹ ⁵⁸

Sleep Phase Syndrome, Advanced, Familial ³⁸

Advanced Sleep Phase Syndrome, Familial ¹⁹

Advanced Sleep-Phase Syndrome, Familial ⁷¹

Familial Advanced Sleep Phase Syndrome ¹⁹

Characteristics:

Inheritance:

Familial Advanced Sleep-Phase Syndrome: Autosomal dominant ⁵⁸

Age Of Onset:

Familial Advanced Sleep-Phase Syndrome: Adolescent,Childhood ⁵⁸

Classifications:

MalaCards categories:
Global: Rare diseases Genetic diseases
Anatomical: Neuronal diseases Mental diseases

See all MalaCards categories (disease lists)

ICD10: ³²

Diseases of the nervous system

Episodic and paroxysmal disorders

Sleep disorders

Disorders of the sleep-wake schedule

Orphanet: ⁵⁸

Rare neurological diseases

External Ids:

Disease Ontology ¹¹ DOID:0050628

ICD10 via Orphanet ³² G47.2

UMLS via Orphanet ⁷² C1858496

Orphanet ⁵⁸ ORPHA164736

UMLS ⁷¹ C0751758 C1858496

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Summaries for Advanced Sleep Phase Syndrome

GARD: ¹⁹ A rare genetic neurological disorder characterized by very early sleep onset and offset. Plasma melatonin levels and body core temperature rhythms are also phase-advanced. The sleep-wake cycle is generally shortened. Additional reported features include migraine with or without aura and seasonal affective disorder.

MalaCards based summary: Advanced Sleep Phase Syndrome, also known as fasps, is related to advanced sleep phase syndrome, familial, 1 and sleep disorder. An important gene associated with Advanced Sleep Phase Syndrome is PER2 (Period Circadian Regulator 2), and among its related pathways/superpathways are Neuroscience and Circadian Clock. The drugs Melatonin and Antioxidants have been mentioned in the context of this disorder. Affiliated tissues include hypothalamus and brain, and related phenotypes are Reduced mammosphere formation and nervous system

Orphanet: ⁵⁸ A rare genetic neurological disorder characterized by very early sleep onset and offset. Plasma melatonin levels and body core temperature rhythms are also phase-advanced. The sleep-wake cycle is generally shortened. Additional reported features include migraine with or without aura and seasonal affective disorder.

Disease Ontology: ¹¹ A sleep disorder that involves an altered circadian rhythm resulting in falling asleep in early evening and awaking very early in the morning.

Wikipedia: ⁷⁵ Advanced Sleep Phase Disorder (ASPD), also known as the advanced sleep-phase type (ASPT) of circadian... more...

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Related Diseases for Advanced Sleep Phase Syndrome

Diseases in the Advanced Sleep Phase Syndrome family:

Advanced Sleep Phase Syndrome, Familial, 1	Advanced Sleep Phase Syndrome, Familial, 2
Advanced Sleep Phase Syndrome, Familial, 3

Diseases related to Advanced Sleep Phase Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 21)

#	Related Disease	Score	Top Affiliating Genes
1	advanced sleep phase syndrome, familial, 1	33.4	PER2 BHLHE41
2	sleep disorder	29.9	PER3 PER2 OPN4 NR1D1 NPAS2 HCRT
3	delayed sleep phase disorder	29.0	TIMELESS PER3 PER2 OPN4 NR1D1 NPAS2
4	advanced sleep phase syndrome, familial, 2	12.1
5	advanced sleep phase syndrome, familial, 3	12.0
6	advance sleep phase syndrome, familial, 4	11.4
7	alveolar soft part sarcoma	10.3
8	bile duct cystadenoma	10.2	PER3 CLOCK BMAL1
9	hypersomnia	10.2	OPN4 HCRT
10	contractures, pterygia, and spondylocarpotarsal fusion syndrome 1a	10.2
11	periodic limb movement disorder	10.2	PER3 PER2 HCRT
12	idiopathic hypersomnia	10.2	OPN4 HCRT
13	apnea, obstructive sleep	10.2	HCRT CRY1 BMAL1
14	dysthymic disorder	10.1	HCRT CRY2
15	rem sleep behavior disorder	10.1	PER2 PER1 NR1D1 HCRT BMAL1
16	narcolepsy	10.0
17	migraine with or without aura 1	10.0	VIPR2 OPN4 HCRT CSNK1D
18	attention deficit-hyperactivity disorder	10.0	VIPR2 PER2 HCRT CRY1
19	restless legs syndrome	9.9	NPAS2 HCRT CLOCK
20	bipolar disorder	9.7	TIMELESS PER3 PER2 NR1D1 NPAS2 CSNK1E
21	major depressive disorder	9.2	VIPR2 TIMELESS PER3 PER2 OPN4 NR1D1

Graphical network of the top 20 diseases related to Advanced Sleep Phase Syndrome:

Sources

Symptoms & Phenotypes for Advanced Sleep Phase Syndrome

GenomeRNAi Phenotypes related to Advanced Sleep Phase Syndrome according to GeneCards Suite gene sharing:

²⁵

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	no effect	GR00402-S-1	10.13	AANAT BHLHE41 BMAL1 CLOCK CRY1 CRY2
2	no effect	GR00402-S-2	10.13	BHLHE41 CLOCK CRY2 CSNK1D CSNK1E FBXL13
3	Reduced mammosphere formation	GR00396-S	9.43	CLOCK CSNK1E NPAS2 NR1D1 PER3 TIMELESS

MGI Mouse Phenotypes related to Advanced Sleep Phase Syndrome:

⁴⁵

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	nervous system	MP:0003631	10	AANAT BMAL1 CLOCK CRY1 CRY2 CSNK1E
2	behavior/neurological	MP:0005386	9.86	BHLHE41 BMAL1 CLOCK CRY1 CRY2 CSNK1D
3	no phenotypic analysis	MP:0003012	9.8	CLOCK CSNK1D CSNK1E NFIL3 NR1D1 PER2
4	vision/eye	MP:0005391	9.32	BMAL1 CRY1 CRY2 FBXL13 NFIL3 NPAS2

Sources

Drugs & Therapeutics for Advanced Sleep Phase Syndrome

Drugs for Advanced Sleep Phase Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

#

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

1

Melatonin

Approved, Nutraceutical, Vet_approved

73-31-4

896

2

Antioxidants

3

Protective Agents

Interventional clinical trials:

#	Name	Status	NCT ID
1	Proteomic and Transcriptomic Biomarkers of Circadian Timing	Recruiting	NCT03956745
2	Proteomic and Transcriptomic Biomarkers of Circadian Timing - Validation of Circadian Biomarkers in Patients With Sleep Disorders	Recruiting	NCT04690504
3	Circadian Rhythms and Sleep in Familial Delayed Sleep Phase Syndrome (DSPS) and Advanced Sleep Phase Syndrome (ASPS)	Recruiting	NCT00246454
4	Breath Biomarkers for Sleep Loss and Circadian Timing	Active, not recruiting	NCT03980340

Search NIH Clinical Center for Advanced Sleep Phase Syndrome

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Genetic Tests for Advanced Sleep Phase Syndrome

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Anatomical Context for Advanced Sleep Phase Syndrome

Organs/tissues related to Advanced Sleep Phase Syndrome:

MalaCards : Hypothalamus, Brain

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Publications for Advanced Sleep Phase Syndrome

Articles related to Advanced Sleep Phase Syndrome:

(show top 50) (show all 87)

#	Title	Authors	PMID	Year
1	[Functional polymorphisms in clock genes and circadian rhythm sleep disorders]. ⁵³ ⁶²	Ebisawa T	17633519	2007
2	Circadian rhythms in the CNS and peripheral clock disorders: human sleep disorders and clock genes. ⁵³ ⁶²	Ebisawa T	17299246	2007
3	A circadian sleep disorder reveals a complex clock. ⁵³ ⁶²	Mignot E...Takahashi JS	17218251	2007
4	Role of phosphorylation in the mammalian circadian clock. ⁵³ ⁶²	Vanselow K...Kramer A	18419274	2007
5	Differential effects of PER2 phosphorylation: molecular basis for the human familial advanced sleep phase syndrome (FASPS). ⁵³ ⁶²	Vanselow K...Kramer A	16983144	2006
6	Genetics of the sleep-wake cycle and its disorders. ⁵³ ⁶²	Hamet P...Tremblay J	16979429	2006
7	From circadian clock mechanism to sleep disorders and jet lag: Insights from a computational approach. ⁶²	Goldbeter A...Leloup JC	33617843	2021
8	Sleep phenotype of individuals with autism spectrum disorder bearing mutations in the PER2 circadian rhythm gene. ⁶²	Hoang N...Scherer SW	33474825	2021
9	CK2 Inhibits TIMELESS Nuclear Export and Modulates CLOCK Transcriptional Activity to Regulate Circadian Rhythms. ⁶²	Cai YD...Chiu JC	33217322	2021
10	Recent Advances in the Development of Casein Kinase 1 Inhibitors. ⁶²	Li SS...Liu ZP	32660395	2021
11	"Circadian misalignment and the gut microbiome. A bidirectional relationship triggering inflammation and metabolic disorders"- a literature review. ⁶²	Mashaqi S...Gozal D	32559717	2020
12	Genetics of migraine aura: an update. ⁶²	de Boer I...van den Maagdenberg AMJM	32503413	2020
13	NAD+ Controls Circadian Reprogramming through PER2 Nuclear Translocation to Counter Aging. ⁶²	Levine DC...Bass J	32369735	2020
14	Genetic mouse models of migraine. ⁶²	Pietrobon D...Brennan KC	31299902	2019
15	Optimized 4,5-Diarylimidazoles as Potent/Selective Inhibitors of Protein Kinase CK1δ and Their Structural Relation to p38α MAPK. ⁶²	Halekotte J...Peifer C	28338621	2017
16	A FERONIA-Like Receptor Kinase Regulates Strawberry (Fragaria × ananassa) Fruit Ripening and Quality Formation. ⁶²	Jia M...Jia W	28702036	2017
17	Rigid Cooperation of Per1 and Per2 proteins. ⁶²	Tamiya H...Akishita M	27609640	2016
18	Animal models of monogenic migraine. ⁶²	Chen SP...Eikermann-Haerter K	27154999	2016
19	From migraine genes to mechanisms. ⁶²	Tolner EA...van den Maagdenberg AMJM	25789438	2015
20	PER1 phosphorylation specifies feeding rhythm in mice. ⁶²	Liu Z...Xu Y	24857656	2014
21	Migraine and sleep: new connections. ⁶²	Ahn AH...Goadsby PJ	24765233	2013
22	Genetic and immunologic aspects of sleep and sleep disorders. ⁶²	Parish JM	23648914	2013
23	Neurodegenerative Disease and REM Behavior Disorder. ⁶²	Malhotra R...Avidan AY	22879077	2012
24	Cognitive and behavioral treatment options for insomnia. ⁶²	Ebben MR...Narizhnaya M	22786741	2012
25	The circadian mutation PER2(S662G) is linked to cell cycle progression and tumorigenesis. ⁶²	Gu X...Xu Y	21818120	2012
26	An association analysis of Per2 with panic disorder in the Japanese population. ⁶²	Otowa T...Sasaki T	21814225	2011
27	The period of the circadian oscillator is primarily determined by the balance between casein kinase 1 and protein phosphatase 1. ⁶²	Lee HM...Lee C	21930935	2011
28	Casein kinase 1-dependent phosphorylation of familial advanced sleep phase syndrome-associated residues controls PERIOD 2 stability. ⁶²	Shanware NP...Tibbetts RS	21324900	2011
29	[Genetics of sleep]. ⁶²	Koval'zon VM	21786645	2011
30	miRNA-132 orchestrates chromatin remodeling and translational control of the circadian clock. ⁶²	Alvarez-Saavedra M...Cheng HY	21118894	2011
31	Disease and Degeneration of Aging Neural Systems that Integrate Sleep Drive and Circadian Oscillations. ⁶²	Singletary KG...Naidoo N	22028699	2011
32	Behavioral and genetic dissection of a mouse model for advanced sleep phase syndrome. ⁶²	Jiang P...O'Hara BF	21203370	2011
33	Modelling the dual role of Per phosphorylation and its effect on the period and phase of the mammalian circadian clock. ⁶²	Leloup JC...Goldbeter A	21261401	2011
34	Segregation of expression of mPeriod gene homologs in neurons and glia: possible divergent roles of mPeriod1 and mPeriod2 in the brain. ⁶²	Cheng HY...Obrietan K	19477955	2009
35	[Timekeeping molecules: implications for circadian phenotypes]. ⁶²	Pereira DS...Pedrazzoli M	19506779	2009
36	Disruption of the circadian timing systems: molecular mechanisms in mood disorders. ⁶²	Mendlewicz J	19708722	2009
37	The roles of melatonin and light in the pathophysiology and treatment of circadian rhythm sleep disorders. ⁶²	Pandi-Perumal SR...Cardinali DP	18628753	2008
38	Modeling the circadian clock: from molecular mechanism to physiological disorders. ⁶²	Leloup JC...Goldbeter A	18478538	2008
39	The genetic basis of sleep disorders. ⁶²	Dauvilliers Y...Tafti M	19075715	2008
40	Protein kinase A and casein kinases mediate sequential phosphorylation events in the circadian negative feedback loop. ⁶²	Huang G...Liu Y	18079175	2007
41	Circadian rhythmicity and the pharmacologic management of insomnia. ⁶²	Richardson GS...Bramley TJ	18041873	2007
42	[Normal and disordered sleep]. ⁶²	Arnulf I	17652992	2007
43	Narcolepsy and familial advanced sleep-phase syndrome: molecular genetics of sleep disorders. ⁶²	Tafti M...Overeem S	17467264	2007
44	Beyond intuitive modeling: combining biophysical models with innovative experiments to move the circadian clock field forward. ⁶²	Forger D...Welsh DK	17517910	2007
45	Practice parameters for the use of actigraphy in the assessment of sleep and sleep disorders: an update for 2007. ⁶²	Morgenthaler T...American Academy of Sleep Medicine	17520797	2007
46	Novel insights from genetic and molecular characterization of the human clock. ⁶²	Ptacek LJ...Fu YH	18419283	2007
47	Modeling of a human circadian mutation yields insights into clock regulation by PER2. ⁶²	Xu Y...Ptacek LJ	17218255	2007
48	Circadian rhythm sleep disorders and phototherapy. ⁶²	Fahey CD...Zee PC	17118278	2006
49	Genetic basis for sleep regulation and sleep disorders. ⁶²	Raizen DM...Pack AI	17048148	2006
50	Sleep in persons with dementia: Increasing quality of life by managing sleep disorders. ⁶²	Cole CS...Richards KC	16544457	2006

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Genes for Advanced Sleep Phase Syndrome

Genes related to Advanced Sleep Phase Syndrome (3 elite genes):

(show all 34)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubMed IDs
1	PER2	Period Circadian Regulator 2	Protein Coding	398.22	Causative germline mutation ⁵⁸ DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Disorders Publications (show sections)	11232563 17299246 18419274 (more) 16983144 16979429 17633519 17218251
2	PER3	Period Circadian Regulator 3	Protein Coding	386.13	Causative germline mutation ⁵⁸ DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Disorders Publications (show sections)	26903630 16979429
3	CSNK1D	Casein Kinase 1 Delta	Protein Coding	375.88	Causative germline mutation ⁵⁸ DISEASES inferred ¹⁴ GeneCards inferred via : Disorders Publications (show sections)	15800623
4	PER1	Period Circadian Regulator 1	Protein Coding	12.91	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
5	CRY1	Cryptochrome Circadian Regulator 1	Protein Coding	7.8	DISEASES inferred ¹⁴
6	BMAL1	Basic Helix-Loop-Helix ARNT Like 1	Protein Coding	7.68	DISEASES inferred ¹⁴
7	CRY2	Cryptochrome Circadian Regulator 2	Protein Coding	7.65	DISEASES inferred ¹⁴
8	CLOCK	Clock Circadian Regulator	Protein Coding	7.49	DISEASES inferred ¹⁴
9	CSNK1E	Casein Kinase 1 Epsilon	Protein Coding	7.38	DISEASES inferred ¹⁴
10	NPAS2	Neuronal PAS Domain Protein 2	Protein Coding	7.38	DISEASES inferred ¹⁴
11	FBXL3	F-Box And Leucine Rich Repeat Protein 3	Protein Coding	7.29	DISEASES inferred ¹⁴
12	NR1D1	Nuclear Receptor Subfamily 1 Group D Member 1	Protein Coding	7.1	DISEASES inferred ¹⁴
13	BHLHE41	Basic Helix-Loop-Helix Family Member E41	Protein Coding	6.99	DISEASES inferred ¹⁴
14	TIMELESS	Timeless Circadian Regulator	Protein Coding	6.55	DISEASES inferred ¹⁴
15	OPN4	Opsin 4	Protein Coding	6.47	DISEASES inferred ¹⁴
16	HCRT	Hypocretin Neuropeptide Precursor	Protein Coding	6.23	DISEASES inferred ¹⁴
17	FBXL13	F-Box And Leucine Rich Repeat Protein 13	Protein Coding	6.04	DISEASES inferred ¹⁴
18	AANAT	Aralkylamine N-Acetyltransferase	Protein Coding	5.74	DISEASES inferred ¹⁴
19	NFIL3	Nuclear Factor, Interleukin 3 Regulated	Protein Coding	5.68	DISEASES inferred ¹⁴
20	VIPR2	Vasoactive Intestinal Peptide Receptor 2	Protein Coding	5.62	DISEASES inferred ¹⁴
21	HCRTR2	Hypocretin Receptor 2	Protein Coding	5.52	DISEASES inferred ¹⁴
22	LINC-ROR	Long Intergenic Non-Protein Coding RNA, Regulator Of Reprogramming	RNA Gene	5.51	DISEASES inferred ¹⁴
23	RORB	RAR Related Orphan Receptor B	Protein Coding	5.48	DISEASES inferred ¹⁴
24	SIK3	SIK Family Kinase 3	Protein Coding	5.46	DISEASES inferred ¹⁴
25	BTBD9	BTB Domain Containing 9	Protein Coding	5.45	DISEASES inferred ¹⁴
26	RORA	RAR Related Orphan Receptor A	Protein Coding	5.41	DISEASES inferred ¹⁴
27	NALCN	Sodium Leak Channel, Non-Selective	Protein Coding	5.4	DISEASES inferred ¹⁴
28	BMAL2	Basic Helix-Loop-Helix ARNT Like 2	Protein Coding	5.35	DISEASES inferred ¹⁴
29	NR1D2	Nuclear Receptor Subfamily 1 Group D Member 2	Protein Coding	5.32	DISEASES inferred ¹⁴
30	DBP	D-Box Binding PAR BZIP Transcription Factor	Protein Coding	5.29	DISEASES inferred ¹⁴
31	TEF	TEF Transcription Factor, PAR BZIP Family Member	Protein Coding	5.29	DISEASES inferred ¹⁴
32	ASMT	Acetylserotonin O-Methyltransferase	Protein Coding	5.24	DISEASES inferred ¹⁴
33	PAGE5	PAGE Family Member 5	Protein Coding	5.16	DISEASES inferred ¹⁴
34	ZNG1B	Zn Regulated GTPase Metalloprotein Activator 1B	Protein Coding	5.11	DISEASES inferred ¹⁴

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Variations for Advanced Sleep Phase Syndrome

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Expression for Advanced Sleep Phase Syndrome

Search GEO for disease gene expression data for Advanced Sleep Phase Syndrome.

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Pathways for Advanced Sleep Phase Syndrome

Pathways related to Advanced Sleep Phase Syndrome according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Neuroscience ³	12.33	NR1D1 HCRT CSNK1E CSNK1D BMAL1
2	Circadian Clock ⁶⁶ Show member pathways BMAL1:CLOCK,NPAS2 activates circadian gene expression ⁶⁶ Circadian Clock in Mammals ⁶⁴ Heme signaling ⁶⁶ NR1D1 (REV-ERBA) represses gene expression ⁶⁶ RORA activates gene expression ⁶⁶	12.25	BHLHE41 BMAL1 CLOCK CRY1 CRY2 CSNK1D
3	PPARA activates gene expression ⁶⁶ Show member pathways Regulation of lipid metabolism by PPARalpha ⁶⁶ Transcriptional regulation of white adipocyte differentiation ⁶⁶	12.24	NR1D1 NPAS2 CLOCK BMAL1
4	Clock-controlled autophagy in bone metabolism ⁷⁴	11.75	PER1 NPAS2 CRY1 CLOCK BMAL1 BHLHE41
5	Th17 cell differentiation pathway ⁷⁴	11.64	PER1 NR1D1 NFIL3 CRY1 CLOCK BMAL1
6	Exercise-induced circadian regulation ⁷⁴	11.42	BMAL1 CLOCK CRY1 CRY2 PER1 PER2
7	Metabolic States and Circadian Oscillators ⁶⁴ Show member pathways Circadian rhythm pathway ⁶¹ lactate fermentation (reoxidation of cytosolic NADH) ⁶¹ methylglyoxal degradation VI ⁶¹	11.09	BMAL1 CLOCK CRY1 CRY2 CSNK1E NPAS2
8	Melatonin metabolism and effects ⁷⁴	10.72	AANAT BMAL1 CLOCK CRY1 CRY2 PER1

Sources

GO Terms for Advanced Sleep Phase Syndrome

Cellular components related to Advanced Sleep Phase Syndrome according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	chromatoid body	GO:0033391	9.26	CLOCK BMAL1
2	CLOCK-BMAL transcription complex	GO:1990513	9.1	NPAS2 CLOCK BMAL1

Biological processes related to Advanced Sleep Phase Syndrome according to GeneCards Suite gene sharing:

(show all 24)

#	Name	GO ID	Score	Top Affiliating Genes
1	negative regulation of transcription by RNA polymerase II	GO:0000122	10.48	PER3 PER2 PER1 NR1D1 NFIL3 CRY2
2	negative regulation of DNA-templated transcription	GO:0045892	10.4	BHLHE41 BMAL1 CLOCK CRY1 CRY2 NFIL3
3	circadian regulation of gene expression	GO:0032922	10.34	BMAL1 BHLHE41 PER3 PER2 PER1 NR1D1
4	circadian rhythm	GO:0007623	10.18	TIMELESS PER3 PER2 PER1 NR1D1 NFIL3
5	entrainment of circadian clock by photoperiod	GO:0043153	10.15	PER3 PER2 PER1 FBXL3 CRY2 CRY1
6	response to insulin	GO:0032868	10.09	CRY2 CRY1 AANAT
7	regulation of insulin secretion	GO:0050796	10.07	PER2 CLOCK BMAL1
8	regulation of neurogenesis	GO:0050767	10.06	BHLHE41 BMAL1 PER2
9	negative regulation of glucocorticoid receptor signaling pathway	GO:2000323	10.02	BMAL1 CLOCK CRY1 CRY2 PER1
10	response to light stimulus	GO:0009416	9.98	PER1 CRY2 CRY1 AANAT
11	response to redox state	GO:0051775	9.97	NPAS2 CLOCK BMAL1
12	negative regulation of circadian rhythm	GO:0042754	9.95	CRY1 CRY2 PER2
13	regulation of hair cycle	GO:0042634	9.93	PER1 CLOCK BMAL1
14	rhythmic process	GO:0048511	9.93	TIMELESS PER3 PER2 PER1 OPN4 NR1D1
15	histone H3 deacetylation	GO:0070932	9.92	PER2 PER1
16	positive regulation of circadian rhythm	GO:0042753	9.91	CLOCK BMAL1
17	positive regulation of non-canonical Wnt signaling pathway	GO:2000052	9.9	CSNK1E CSNK1D
18	circadian regulation of translation	GO:0097167	9.87	PER1 PER2
19	regulation of type B pancreatic cell development	GO:2000074	9.86	BMAL1 CLOCK
20	negative regulation of glucocorticoid secretion	GO:2000850	9.85	CRY2 CRY1
21	positive regulation of Wnt-mediated midbrain dopaminergic neuron differentiation	GO:1905426	9.84	CSNK1E CSNK1D
22	blue light signaling pathway	GO:0009785	9.83	CRY2 CRY1
23	photoperiodism	GO:0009648	9.81	CLOCK AANAT
24	regulation of circadian rhythm	GO:0042752	9.66	TIMELESS PER2 PER1 OPN4 NR1D1 FBXL3

Molecular functions related to Advanced Sleep Phase Syndrome according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	DNA binding	GO:0003677	10.35	TIMELESS NR1D1 NPAS2 NFIL3 CRY2 CRY1
2	transcription cis-regulatory region binding	GO:0000976	10.03	PER3 PER2 PER1 NR1D1 CRY2 BMAL1
3	protein dimerization activity	GO:0046983	10	NPAS2 CLOCK BMAL1 BHLHE41
4	kinase binding	GO:0019900	9.91	PER3 PER1 CRY2 CRY1
5	transcription corepressor binding	GO:0001222	9.76	PER3 PER2 PER1 NR1D1
6	blue light photoreceptor activity	GO:0009882	9.71	CRY2 CRY1
7	E-box binding	GO:0070888	9.4	PER1 NR1D1 CRY1 CLOCK BMAL1 BHLHE41
8	deoxyribodipyrimidine photo-lyase activity	GO:0003904	9.37	CRY1 CRY2
9	DNA (6-4) photolyase activity	GO:0003914	9.32	CRY1 CRY2
10	photoreceptor activity	GO:0009881	9.13	OPN4 CRY2 CRY1

Sources

Sources for Advanced Sleep Phase Syndrome

¹ BitterDB

² CDC

³ Cell Signaling Technology

⁴ ClinicalTrials

⁵ ClinVar

⁶ CNVD

⁷ Cochrane Library

⁸ Cosmic

⁹ dbSNP

¹⁰ DGIdb

¹¹ Disease Ontology

¹² diseasecard

¹³ DiseaseEnhancer

¹⁴ DISEASES

¹⁵ DrugBank

¹⁶ EFO

¹⁷ ExPASy

¹⁸ FMA

¹⁹ GARD

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ GenomeRNAi

²⁶ GEO DataSets

²⁷ GO

²⁸ GTR

²⁹ HMDB

³⁰ HPO

³¹ ICD10

³² ICD10 via Orphanet

³³ ICD11

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ LifeMap

³⁷ LncRNADisease

³⁸ LOVD

³⁹ MalaCards

⁴⁰ MedGen

⁴¹ MedlinePlus

⁴² MedlinePlus Genetics

⁴³ MeSH

⁴⁴ MESH via Orphanet

⁴⁵ MGI

⁴⁶ miR2Disease

⁴⁷ NCBI Bookshelf

⁴⁸ NCI

⁴⁹ NCIt

⁵⁰ NDF-RT

⁵¹ NIH Clinical Center

⁵² NINDS

⁵³ Novoseek

⁵⁴ Novus Biologicals

⁵⁵ ODiseA

⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 08-Dec-2022)

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubChem

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ WikiPathways

⁷⁵ Wikipedia

FASPS MCID: ADV001 MIFTS: 39	Advanced Sleep Phase Syndrome (FASPS) Categories: Genetic diseases, Mental diseases, Neuronal diseases, Rare diseases	Data Licensing For inquiries, contact: [email protected]
Genes Tissues Related diseases Publications Drugs Expand all tables

Advanced Sleep Phase Syndrome (FASPS)

Aliases & Classifications for Advanced Sleep Phase Syndrome

MalaCards integrated aliases for Advanced Sleep Phase Syndrome:

Characteristics:

Inheritance:

Age Of Onset:

Classifications:

External Ids:

Summaries for Advanced Sleep Phase Syndrome

Related Diseases for Advanced Sleep Phase Syndrome

Diseases in the Advanced Sleep Phase Syndrome family:

Diseases related to Advanced Sleep Phase Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

Graphical network of the top 20 diseases related to Advanced Sleep Phase Syndrome:

Symptoms & Phenotypes for Advanced Sleep Phase Syndrome

GenomeRNAi Phenotypes related to Advanced Sleep Phase Syndrome according to GeneCards Suite gene sharing:

MGI Mouse Phenotypes related to Advanced Sleep Phase Syndrome:

Drugs & Therapeutics for Advanced Sleep Phase Syndrome

Drugs for Advanced Sleep Phase Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

Interventional clinical trials:

Genetic Tests for Advanced Sleep Phase Syndrome

Anatomical Context for Advanced Sleep Phase Syndrome

Organs/tissues related to Advanced Sleep Phase Syndrome:

Publications for Advanced Sleep Phase Syndrome

Articles related to Advanced Sleep Phase Syndrome:

Genes for Advanced Sleep Phase Syndrome

Genes related to Advanced Sleep Phase Syndrome (3 elite genes):

Variations for Advanced Sleep Phase Syndrome

Expression for Advanced Sleep Phase Syndrome

Pathways for Advanced Sleep Phase Syndrome

Pathways related to Advanced Sleep Phase Syndrome according to GeneCards Suite gene sharing:

GO Terms for Advanced Sleep Phase Syndrome

Cellular components related to Advanced Sleep Phase Syndrome according to GeneCards Suite gene sharing:

Biological processes related to Advanced Sleep Phase Syndrome according to GeneCards Suite gene sharing:

Molecular functions related to Advanced Sleep Phase Syndrome according to GeneCards Suite gene sharing:

Sources for Advanced Sleep Phase Syndrome