MCID: AFF001
MIFTS: 27

Afferent Loop Syndrome

Categories: Gastrointestinal diseases

Aliases & Classifications for Afferent Loop Syndrome

MalaCards integrated aliases for Afferent Loop Syndrome:

Name: Afferent Loop Syndrome 12 44 15 17 70
Afferent Limb Syndrome 12

Classifications:



External Ids:

Disease Ontology 12 DOID:8438
MeSH 44 D000343
SNOMED-CT 67 20813000
UMLS 70 C0001727

Summaries for Afferent Loop Syndrome

Disease Ontology : 12 A postgastrectomy syndrome that is characterized by obstruction of the afferent loop that arises after gastric surgery with gastrojejunostomy reconstruction.

MalaCards based summary : Afferent Loop Syndrome, also known as afferent limb syndrome, is related to cholangitis and peptic ulcer disease, and has symptoms including pain, postoperative and postoperative nausea and vomiting. An important gene associated with Afferent Loop Syndrome is GPT (Glutamic--Pyruvic Transaminase). Affiliated tissues include pancreas.

Related Diseases for Afferent Loop Syndrome

Diseases related to Afferent Loop Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 263)
# Related Disease Score Top Affiliating Genes
1 cholangitis 31.0 GPT ALB
2 peptic ulcer disease 30.6 ATP4A ATP12A
3 ascending cholangitis 30.6 GPT ALB
4 acute cholangitis 30.5 GPT ALB
5 obstructive jaundice 30.2 GPT ALB
6 gastrojejunal ulcer 30.2 ATP4A ATP12A
7 choledocholithiasis 30.1 GPT ALB
8 microinvasive gastric cancer 29.9 ATP4A ATP12A
9 hyperthyroidism 29.7 GPT ALB
10 intestinal obstruction 29.6 GPT ATP4A ATP12A ALB
11 active peptic ulcer disease 29.6 ATP4A ATP12A ALB
12 volvulus of midgut 29.4 GPT ATP4A ATP12A ALB
13 deficiency anemia 29.4 GPT ATP4A ATP12A ALB
14 paralytic ileus 29.2 GPT ATP4A ATP12A ALB
15 acute pancreatitis 10.5
16 pancreatitis 10.4
17 dumping syndrome 10.3
18 overgrowth syndrome 10.3
19 gastric cancer 10.2
20 gastric ulcer 10.2
21 ulcerative colitis 10.2
22 cholecystitis 10.2 GPT ALB
23 dipetalonemiasis 10.1 GPT ALB
24 heterophyiasis 10.1 GPT ALB
25 ankylosing spondylitis 1 10.1 GPT ALB
26 acalculous cholecystitis 10.1 GPT ALB
27 hepatic infarction 10.1 GPT ALB
28 hydrops of gallbladder 10.1 GPT ALB
29 critical illness polyneuropathy 10.1 GPT ALB
30 gastrointestinal tuberculosis 10.1 GPT ALB
31 granulomatous hepatitis 10.1 GPT ALB
32 common bile duct disease 10.1 GPT ALB
33 bile duct disease 10.1 GPT ALB
34 coronary aneurysm 10.1 GPT ALB
35 hepatic coma 10.1 GPT ALB
36 abdominal tuberculosis 10.1 GPT ALB
37 bile duct cysts 10.1 GPT ALB
38 heart aneurysm 10.1 GPT ALB
39 splenic infarction 10.1 GPT ALB
40 pyuria 10.1 GPT ALB
41 pleural empyema 10.1 GPT ALB
42 kwashiorkor 10.1 GPT ALB
43 dicrocoeliasis 10.1 GPT ALB
44 klatskin's tumor 10.1 GPT ALB
45 analbuminemia 10.1 GPT ALB
46 babesiosis 10.1 GPT ALB
47 compartment syndrome 10.1 GPT ALB
48 hepatic tuberculosis 10.1 GPT ALB
49 reye syndrome 10.1 GPT ALB
50 tricuspid valve disease 10.1 GPT ALB

Graphical network of the top 20 diseases related to Afferent Loop Syndrome:



Diseases related to Afferent Loop Syndrome

Symptoms & Phenotypes for Afferent Loop Syndrome

UMLS symptoms related to Afferent Loop Syndrome:


pain, postoperative; postoperative nausea and vomiting

Drugs & Therapeutics for Afferent Loop Syndrome

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Prospective Study to Evaluate the Safety and Feasibility of an Endoluminal-suturing Device (Endomina TM) as an Aid for Afferent Loop Syndrome Completed NCT03608267

Search NIH Clinical Center for Afferent Loop Syndrome

Cochrane evidence based reviews: afferent loop syndrome

Genetic Tests for Afferent Loop Syndrome

Anatomical Context for Afferent Loop Syndrome

MalaCards organs/tissues related to Afferent Loop Syndrome:

40
Pancreas

Publications for Afferent Loop Syndrome

Articles related to Afferent Loop Syndrome:

(show top 50) (show all 262)
# Title Authors PMID Year
1
Endoscopic ultrasonography (EUS) -guided visceral anastomoses: indications and techniques. 61
33793153 2021
2
Endoscopic ultrasound-guided jejunojejunostomy with rendezvous contrast-filling assistance in afferent limb syndrome. 61
33682909 2021
3
Endoscopic gastrointestinal anastomosis: a review of established techniques. 61
32593687 2021
4
Treatment of afferent loop syndrome using fluoroscopic-guided nasointestinal tube placement: Two case reports. 61
33269270 2020
5
Percutaneous- and EUS-guided gastroenterostomy for malignant afferent limb syndrome. 61
33204911 2020
6
Placing a lumen-apposing metal stent despite ascites: feasibility and safety. 61
33204927 2020
7
Diagnosis and treatment of the afferent loop syndrome. 61
32638230 2020
8
Pouch wall thickness and floppy pouch complex. 61
31650238 2020
9
Afferent limb syndrome after total proctocolectomy and ileal pouch-anal canal anastomosis. 61
32797327 2020
10
Endoscopic Ultrasound-Guided Enteroenterostomy for Afferent Limb Syndrome. 61
32821770 2020
11
Endoscopic electrohydraulic lithotripsy of an enterolith causing afferent loop syndrome after Whipple's operation. 61
31791103 2020
12
Single-step EUS-guided jejunojejunostomy with a lumen-apposing metal stent as treatment for malignant afferent limb syndrome. 61
32258847 2020
13
Lower peripouch fat area is related with increased frequency of pouch prolapse and floppy pouch complex in inflammatory bowel disease patients. 61
32020266 2020
14
Endoscopic ultrasound-guided management of malignant afferent loop syndrome after gastric bypass: from diagnosis to therapy. 61
31261429 2020
15
Treatment of afferent loop syndrome using digital cholangioscopy through the percutaneous transhepatic biliary drainage route. 61
31529436 2020
16
Management of afferent loop syndrome after Roux-en-Y subtotal gastrectomy and choledocolithiasis with recurrent cholangitis. 61
31907217 2020
17
Afferent Loop Syndrome with Intestinal Ischemia due to Internal Hernia after Whipple Operation for T2N1M0 Pancreatic Cancer. 61
32754378 2020
18
A "Kissing-Stents" Technique in the Management of Afferent Limb Syndrome With Concomitant Efferent Limb Obstruction in a Patient With Gastric Cancer and Billroth II Anatomy. 61
32309485 2020
19
EUS-guided enteroenterostomy for nonoperative management of afferent loop syndrome after Whipple resection. 61
31709330 2019
20
Endoscopic ultrasound-guided gastrojejunostomy using fully covered metal stent combined with large-loop double-pigtail stent for malignant afferent loop syndrome. 61
31121623 2019
21
Afferent loop syndrome of 10 years' onset after gastrectomy. 61
31301932 2019
22
Retrospective cohort study of 925 OAGB procedures. The UK MGB/OAGB collaborative group. 61
31299430 2019
23
Efficiency and risks of laparoscopic conversion of omega anastomosis gastric bypass to Roux-en-Y gastric bypass. 61
30353237 2019
24
Afferent Loop Syndrome Due to Volvulus of the Afferent Limb. 61
31620523 2019
25
Endoscopic ultrasound-guided gastrojejunostomy using a 2-cm lumen-apposing metal stent to treat benign afferent loop syndrome. 61
30978736 2019
26
Endoscopic ultrasound-guided gastroenterostomy using a metal stent for the treatment of afferent loop syndrome. 61
30934100 2019
27
Characterization of risk factors for floppy pouch complex in ulcerative colitis. 61
30972491 2019
28
The Implications of Pouch Physiology. 61
30844976 2019
29
Magnetic resonance cholangiopancreatography for afferent loop syndrome. 61
30899506 2019
30
[Two Cases of Afferent Loop Obstruction Treated with Percutaneous Bowel Drainage(PBD)]. 61
30914570 2019
31
Self-expanding metal stent procedure for afferent loop syndrome with ascending cholangitis caused by remnant gastric cancer: A case report. 61
30557964 2018
32
Diagnosis and management of floppy pouch complex. 61
30430012 2018
33
Successful emergency endoscopic drainage for afferent limb syndrome-induced severe acute cholangitis in a patient with altered Roux-en Y anatomy. 61
30039511 2018
34
EUS-guided gastroenterostomy for afferent loop syndrome treatment stent. 61
30004036 2018
35
Enteral self-expandable metal stent placement for malignant afferent limb syndrome using single-balloon enteroscope: report of five cases. 61
30410953 2018
36
Endoscopic ultrasound-guided entero-enterostomy for the treatment of afferent loop syndrome: a multicenter experience. 61
29499577 2018
37
Metal Stent Placement in the Afferent Loop Obstructed by Peritoneal Metastases-Experience of Five Cases. 61
29665632 2018
38
Cholangitis secondary to afferent loop syndrome from a gastric stump adenocarcinoma. 61
29620408 2018
39
A Case of Non-Obstructive Afferent Loop Syndrome after Roux-en-Y Gastric Bypass. 61
29580365 2018
40
Treatment of neoplastic afferent limb syndrome by endoscopic gastrojejunostomy with a lumen-apposing metal stent. 61
29905184 2018
41
Endoscopic ultrasound guided gastrojejunostomy. 61
30603729 2018
42
Laparoscopic revision of Billroth II with Braun anastomosis into Roux-en-Y anatomy in a patient with intestinal malrotation. 61
28643070 2018
43
Complications in children with ulcerative colitis undergoing ileal pouch-anal anastomosis. 61
29126508 2017
44
Afferent loop syndrome treated by endoscopic ultrasound-guided gastrojejunostomy, using a lumen-apposing metal stent with an electrocautery-enhanced delivery system. 61
28799148 2017
45
Laparoscopic ileopexy for afferent limb syndrome after ileal pouch-anal anastomosis. 61
28664652 2017
46
[A Case of Roux-en-Y Loop Reconstruction Using a Modified Aboral Pouch Technique for Y-Limb Obstruction Following Distal Gastrectomy]. 61
29066699 2017
47
Early postoperative imaging after non-bariatric gastric resection: a primer for radiologists. 61
28631148 2017
48
Percutaneous Creation of a Gastrojejunal Bypass Anastomosis Using a Lumen-Apposing Stent to Treat Afferent Limb Syndrome. 61
28532749 2017
49
Endoscopic management of afferent loop syndrome caused by enteroliths and anastomotic stricture. A case report. 61
28597677 2017
50
Short- and long-term outcomes after pancreaticoduodenectomy following total gastorectomy: Report of case series and literature review. 61
28012325 2017

Variations for Afferent Loop Syndrome

Expression for Afferent Loop Syndrome

Search GEO for disease gene expression data for Afferent Loop Syndrome.

Pathways for Afferent Loop Syndrome

GO Terms for Afferent Loop Syndrome

Biological processes related to Afferent Loop Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 potassium ion import across plasma membrane GO:1990573 9.32 ATP4A ATP12A
2 cellular sodium ion homeostasis GO:0006883 9.26 ATP4A ATP12A
3 sodium ion export across plasma membrane GO:0036376 9.16 ATP4A ATP12A
4 cellular potassium ion homeostasis GO:0030007 8.96 ATP4A ATP12A
5 establishment or maintenance of transmembrane electrochemical gradient GO:0010248 8.62 ATP4A ATP12A

Molecular functions related to Afferent Loop Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 pyridoxal phosphate binding GO:0030170 9.26 GPT ALB
2 sodium:potassium-exchanging ATPase activity GO:0005391 9.16 ATP4A ATP12A
3 potassium-transporting ATPase activity GO:0008556 8.96 ATP4A ATP12A
4 potassium:proton exchanging ATPase activity GO:0008900 8.62 ATP4A ATP12A

Sources for Afferent Loop Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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