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MCID: AFR001
MIFTS: 24

African Histoplasmosis

Categories: Bone diseases, Infectious diseases
Genes Tissues Related diseases Publications Pathways
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Aliases & Classifications for African Histoplasmosis

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MalaCards integrated aliases for African Histoplasmosis:

Name: African Histoplasmosis 12 15 72

Classifications:

MalaCards categories:
Global: Infectious diseases
Anatomical: Bone diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:11315
ICD9CM 35 115.10
UMLS 72 C0153270 C0220977
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Summaries for African Histoplasmosis

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Disease Ontology : 12 A histoplasmosis that results in systemic fungal infection, has material basis in Histoplasma capsulatum var duboisii, transmitted by airborne spores and results in formation of nodules, results in formation of ulcers and results in formation of osteolytic bone lesions.

MalaCards based summary : African Histoplasmosis is related to histoplasmosis and osteomyelitis. An important gene associated with African Histoplasmosis is RHNO1 (RAD9-HUS1-RAD1 Interacting Nuclear Orphan 1), and among its related pathways/superpathways are Circadian entrainment and Regulation of TP53 Activity. Affiliated tissues include bone, skin and colon.

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Related Diseases for African Histoplasmosis

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Diseases related to African Histoplasmosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 26)
# Related Disease Score Top Affiliating Genes
1 histoplasmosis 10.8
2 osteomyelitis 10.1
3 burkitt lymphoma 10.0
4 human immunodeficiency virus type 1 10.0
5 paracoccidioidomycosis 10.0
6 blastomycosis 10.0
7 sporotrichosis 10.0
8 acquired immunodeficiency syndrome 10.0
9 osteogenic sarcoma 9.8
10 kala-azar 1 9.8
11 lymphoma 9.8
12 gastric ulcer 9.8
13 cryptococcosis 9.8
14 inflammatory spondylopathy 9.8
15 coccidioidomycosis 9.8
16 chromoblastomycosis 9.8
17 american histoplasmosis 9.8
18 chronic granulomatous disease 9.8
19 tinea capitis 9.8
20 paraplegia 9.8
21 spondylitis 9.8
22 dermatophytosis 9.8
23 leishmaniasis 9.8
24 visceral leishmaniasis 9.8
25 sickle cell disease 9.8
26 mycetoma 9.8

Graphical network of the top 20 diseases related to African Histoplasmosis:



Diseases related to African Histoplasmosis
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Symptoms & Phenotypes for African Histoplasmosis

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Drugs & Therapeutics for African Histoplasmosis

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Search Clinical Trials , NIH Clinical Center for African Histoplasmosis

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Genetic Tests for African Histoplasmosis

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Anatomical Context for African Histoplasmosis

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MalaCards organs/tissues related to African Histoplasmosis:

41
Bone, Skin, Colon, Lung, Lymph Node
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Publications for African Histoplasmosis

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Articles related to African Histoplasmosis:

(show top 50) (show all 146)
# Title Authors PMID Year
1
Modification of the Francis Medium for the Conversion of Histoplasma capsulatum to the Yeast-Like Growth Phase. 38
31177444 2019
2
African Histoplasmosis in HIV-Negative Patients, Kimpese, Democratic Republic of the Congo. 38
30334708 2018
3
Non-tubercular caseous adenopathy in Senegal. 38
30270827 2018
4
African histoplasmosis: new clinical and microbiological insights. 38
28431110 2018
5
Tonsillar ulceration as manifestation of disseminated African histoplasmosis in an immunocompetent Portuguese host. 38
28626627 2017
6
Histoplasmosis by Histoplasma capsulatum var. duboisii Observed at the Laboratory of Pathological Anatomy of Lomé in Togo. 38
28804654 2017
7
[Multifocal histoplasmosis due to Histoplasma capsulatum var. duboisii in a 22 year-old Senegalese patient without proven immunodepression]. 38
27158080 2016
8
[Nondermatophytic and noncandidal fungi isolated in Le Dantec University hospital of Dakar in 2014: Epidemiological, clinical and mycological study]. 38
26138533 2015
9
Disseminated histoplasmosis caused by Histoplasma capsulatum var. duboisii in a non-HIV patient in Burkina Faso: Case report. 38
25840849 2015
10
African histoplasmosis: the first report of an indigenous case in India. 38
25514986 2015
11
Disseminated Histoplasmosis and Secondary Hemophagocytic Syndrome in a Non-HIV Patient. 38
26347828 2015
12
Imported African histoplasmosis in an immunocompetent patient 40 years after staying in a disease-endemic area. 38
25246691 2014
13
[Aspergillus galactomannan assay for the management of histoplasmosis due to Histoplasma capsulatum var. duboisii in HIV-infected patients: education from a clinical case]. 38
24636196 2014
14
[Malian first observation of disseminated African histoplasmosis with predominant bone localizations in an HIV-negative child in Bamako (Mali). Review of the literature]. 38
24094479 2014
15
Posaconazole as rescue therapy in African histoplasmosis. 38
23312726 2013
16
An unusual cutaneous tumor: African histoplasmosis following mudbaths: case report and review. 38
22302860 2012
17
A case of disseminated histoplasmosis detected in peripheral blood smear staining revealing AIDS at terminal phase in a female patient from cameroon. 38
23251167 2012
18
[Disseminated histoplasmosis due to Histoplasma capsulatum var. duboisii in Senegal. A case in HIV-infected patient]. 38
24451506 2011
19
[African histoplasmosis in an immunocompetent Malagasy patient.]. 38
20099053 2010
20
Literature review and case histories of Histoplasma capsulatum var. duboisii infections in HIV-infected patients. 38
18217546 2007
21
[Pathological fracture revealing an osseous histoplasmosis. A case report on a 60-year patient]. 38
17111967 2006
22
African histoplasmosis - masquerading as a malignant bone tumour. 38
17034712 2006
23
[African histoplasmosis (Histoplasma capsulatum var. duboisii): a case report from Mali]. 38
16207583 2005
24
Maxillary African histoplasmosis: unusual diagnostic problems of an unusual presentation. 38
15792130 2005
25
African histoplasmosis infection with peritoneal involvement. 38
15015032 2004
26
[Cervico-facial and ENT symptoms due to HIV infection in tropical area. About 253 Congolese cases]. 38
15104161 2004
27
Histoplasma capsulatum var. capsulatum occurring in an HIV-positive Ghanaian immigrant to Italy. Identification of H. capsulatum DNA by PCR from paraffin sample. 38
11900050 2001
28
[Spondylodiscitis due to Histoplasma duboisii. Report of two cases and review of the literature]. 38
11493872 2001
29
Spinal African histoplasmosis simulating tuberculous spondylitis. 38
12789131 2001
30
Histoplasmosis in Africa: a review. 38
15597674 2000
31
Zoonotic infections in Nigeria: overview from a medical perspective. 38
10913768 2000
32
Antibodies to antigens of Histoplasma, Blastomyces and Candida in HIV patients and carriers in Nigeria. 38
10948814 2000
33
Some deep mycoses diagnosed by histopathology in South Eastern Nigeria. 38
18473552 1999
34
African oral histoplasmosis mimicking lip carcinoma: case report. 38
10520359 1999
35
Fluconazole in the therapy of multiple osteomyelitis in African histoplasmosis. 38
10422020 1999
36
African histoplasmosis: report of two patients treated with amphotericin B and ketoconazole. 38
9916457 1998
37
African histoplasmosis: report of four cases from north-eastern Nigeria. 38
9861834 1998
38
African histoplasmosis: osteomyelitis of the radius. 38
9670760 1998
39
African histoplasmosis: therapeutic efficacy of itraconazole. 38
9552764 1998
40
African histoplasmosis: a review. 38
15538817 1997
41
[African histoplasmosis with ganglionic localisation. Apropos of 1 case in an HIV negative patient]. 38
9410255 1997
42
Focal lesion of African histoplasmosis presenting as a malignant gastric ulcer. 38
8799429 1996
43
[African histoplasmosis in a patient with HIV-2 infection]. 38
8693301 1996
44
Skin and serum reactivity among humans to histoplasmin in the vicinity of a natural focus of Histoplasma capsulatum var. duboisii. 38
9011827 1996
45
Extracellular proteolytic enzyme activity of Histoplasma capsulatum var. duboisii. 38
8817930 1996
46
Fluconazole in the therapy of tropical deep mycoses. 38
8720201 1995
47
[Generalized molluscum contagiosum in an African child with AIDS]. 38
8641888 1995
48
[African histoplasmosis due to Histoplasma capsulatum var. duboisii: relationship with AIDS in recent Congolese cases]. 38
7582643 1995
49
[Multiple bone lesions of a type of disseminated African histoplasmosis in a Togolese immunocompetent child]. 38
8761658 1995
50
[Bone and joint sites of African histoplasmosis (Histoplasma duboisii). Apropos of a case and review of the literature]. 38
7858578 1994
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Variations for African Histoplasmosis

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Expression for African Histoplasmosis

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Search GEO for disease gene expression data for African Histoplasmosis.
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Pathways for African Histoplasmosis

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Pathways related to African Histoplasmosis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Circadian entrainment 37
Show member pathways
 11.83 MAPK14 KRT10
2
Regulation of TP53 Activity 66
Show member pathways
 11.44 RHNO1 MAPK14
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GO Terms for African Histoplasmosis

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Biological processes related to African Histoplasmosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cellular response to DNA damage stimulus GO:0006974 9.16 RHNO1 MAPK14
2 cellular response to ionizing radiation GO:0071479 8.96 RHNO1 MAPK14
3 DNA damage checkpoint GO:0000077 8.62 RHNO1 MAPK14
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Sources for African Histoplasmosis

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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