MCID: AFR002
MIFTS: 33

African Tick-Bite Fever

Categories: Infectious diseases

Aliases & Classifications for African Tick-Bite Fever

MalaCards integrated aliases for African Tick-Bite Fever:

Name: African Tick-Bite Fever 12 15
Rickettsia Africae Spotted Fever 12
South African Tick-Bite Fever 12
African Tick Bite Fever 74

Classifications:



External Ids:

Disease Ontology 12 DOID:0050035
UMLS 74 C1320317

Summaries for African Tick-Bite Fever

Disease Ontology : 12 A spotted fever that has material basis in Rickettsia africae, which is transmitted by ticks (Amblyomma hebraeum and Amblyomma variegatum). The infection has symptom fever, has symptom eschar and has symptom maculopapular rash.

MalaCards based summary : African Tick-Bite Fever, also known as rickettsia africae spotted fever, is related to spotted fever and epidemic typhus, and has symptoms including fever, maculopapular rash and eschar. An important gene associated with African Tick-Bite Fever is IFNG (Interferon Gamma), and among its related pathways/superpathways are NF-kappaB Signaling and Cell adhesion molecules (CAMs). Affiliated tissues include skin, endothelial and lung.

Wikipedia : 77 African tick bite fever (ATBF) is a bacterial infection spread by the bite of a tick. Symptoms may... more...

Related Diseases for African Tick-Bite Fever

Diseases related to African Tick-Bite Fever via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 68)
# Related Disease Score Top Affiliating Genes
1 spotted fever 30.7 CCL5 IFNG
2 epidemic typhus 30.6 CCL5 GPT
3 boutonneuse fever 12.5
4 cutaneous leishmaniasis 10.2
5 endemic typhus 10.2
6 exanthem 10.2
7 queensland tick typhus 10.2
8 cellulitis 10.2
9 internuclear ophthalmoplegia 10.2
10 neuropathy 10.2
11 leishmaniasis 10.2
12 encephalopathy 10.2
13 folliculitis 10.1 CCL5 IFNG
14 orofacial granulomatosis 10.1 CCL5 IFNG
15 viral meningitis 10.1 CCL5 IFNG
16 eumycotic mycetoma 10.1 CCL5 IFNG
17 stevens-johnson syndrome/toxic epidermal necrolysis 10.1 CCL5 IFNG
18 hepatitis a 10.1 GPT IFNG
19 temporal arteritis 10.1 CCL5 IFNG
20 neuritis 10.1 CCL5 IFNG
21 severe acute respiratory syndrome 10.1 CCL5 IFNG
22 tropical spastic paraparesis 10.1 CCL5 IFNG
23 human immunodeficiency virus infectious disease 10.1 CCL5 IFNG
24 filariasis 10.1 CCL5 IFNG
25 pulmonary sarcoidosis 10.1 CCL5 IFNG
26 sporotrichosis 10.1 CD40LG IFNG
27 autoimmune disease of central nervous system 10.1 CCL5 IFNG
28 buruli ulcer 10.1 CD40LG IFNG
29 upper respiratory tract disease 10.1 CCL5 IFNG
30 brucellosis 10.1 CD40LG IFNG
31 bronchiolitis 10.1 CCL5 IFNG
32 relapsing-remitting multiple sclerosis 10.0 CCL5 IFNG
33 secondary progressive multiple sclerosis 10.0 CD40LG IFNG
34 trypanosomiasis 10.0 CCL5 IFNG
35 idiopathic neutropenia 10.0 CCL5 CD40LG
36 dengue disease 10.0 CCL5 CD40LG
37 meningoencephalitis 10.0 CCL5 CD40LG
38 toxoplasmosis 10.0 CD40LG IFNG
39 schistosomiasis 10.0 CD40LG IFNG
40 allergic asthma 10.0 CCL5 IFNG
41 respiratory system disease 10.0 CCL5 IFNG
42 interstitial lung disease 10.0 CCL5 IFNG
43 scleritis 10.0 IFNG SELE
44 chronic active epstein-barr virus infection 10.0 IFNG SELE
45 immunodysregulation, polyendocrinopathy, and enteropathy, x-linked 10.0 CD40LG IFNG
46 tetanus 10.0 CD40LG IFNG
47 plasmodium vivax malaria 10.0 IFNG SELE
48 allergic contact dermatitis 9.9 IFNG SELE
49 contact dermatitis 9.9 IFNG SELE
50 rheumatic disease 9.9 CD40LG IFNG

Graphical network of the top 20 diseases related to African Tick-Bite Fever:



Diseases related to African Tick-Bite Fever

Symptoms & Phenotypes for African Tick-Bite Fever

Symptoms:

12
  • fever
  • maculopapular rash
  • eschar

Drugs & Therapeutics for African Tick-Bite Fever

Search Clinical Trials , NIH Clinical Center for African Tick-Bite Fever

Genetic Tests for African Tick-Bite Fever

Anatomical Context for African Tick-Bite Fever

MalaCards organs/tissues related to African Tick-Bite Fever:

42
Skin, Endothelial, Lung

Publications for African Tick-Bite Fever

Articles related to African Tick-Bite Fever:

(show top 50) (show all 57)
# Title Authors Year
1
African Tick-Bite Fever. ( 30855745 )
2019
2
First report of African tick-bite fever in a South American traveler. ( 29796268 )
2018
3
African Tick Bite Fever Treated Successfully With Rifampin in a Patient With Doxycycline Intolerance. ( 28505276 )
2017
4
African tick bite fever in returning Swedish travellers. Report of two cases and aspects of diagnostics. ( 28815000 )
2017
5
African tick-bite fever - a tantalizing souvenir from South Africa. ( 28872753 )
2017
6
Molecular diagnosis of African tick bite fever using eschar swabs in a traveller returning from Tanzania. ( 27488618 )
2016
7
A case of African tick-bite fever in a returning traveler. ( 27516971 )
2016
8
African Tick-Bite Fever in Traveler Returning to Slovenia from Uganda. ( 27648844 )
2016
9
African tick bite fever. ( 27929573 )
2016
10
Images in clinical medicine: African tick-bite fever after a game-hunting expedition. ( 25738687 )
2015
11
African tick-bite fever in a returning traveler. ( 25795527 )
2015
12
A family with African tick bite fever. ( 25886872 )
2015
13
First case of imported African tick-bite fever in Poland - Case report. ( 26403104 )
2015
14
Case report of African tick-bite fever from Poland. ( 24494003 )
2013
15
Cutaneous leishmaniasis and rickettsial African tick-bite fever: a combination of exotic traveler's diseases in the same patient. ( 22788813 )
2012
16
The use of eschar swabs for the diagnosis of African tick-bite fever. ( 23141102 )
2012
17
Neurological picture. Internuclear ophthalmoplegia following African tick bite fever. ( 21421770 )
2011
18
Risk factors for African tick-bite fever in rural central Africa. ( 21460018 )
2011
19
African tick-bite fever: a new entity in the differential diagnosis of multiple eschars in travelers. Description of five cases imported from South Africa to Switzerland. ( 20233665 )
2010
20
Relative chemokine and adhesion molecule expression in Mediterranean spotted fever and African tick bite fever. ( 19091423 )
2009
21
Diagnosis of Queensland tick typhus and African tick bite fever by PCR of lesion swabs. ( 19523304 )
2009
22
Tache noire in African tick bite fever. ( 19861601 )
2009
23
African tick bite Fever in a Taiwanese traveler returning from South Africa: molecular and serologic studies. ( 19861602 )
2009
24
Unusual location of an inoculation lesion in a traveler with African tick-bite fever returning from South Africa. ( 19930389 )
2009
25
African tick bite fever--papulovesicular exanthem with fever after staying in South Africa. ( 18021248 )
2008
26
African tick bite fever. ( 18218581 )
2008
27
Two cases of cellulitis in the course of African tick bite fever: a fortuitous association? ( 18503259 )
2008
28
African tick bite fever in elderly patients: 8 cases in French tourists returning from South Africa. ( 18558881 )
2008
29
African tick bite fever in a returned traveler. ( 17939635 )
2007
30
Sub-acute neuropathy in patients with African tick bite fever. ( 16449002 )
2006
31
Increased levels of soluble CD40L in African tick bite fever: possible involvement of TLRs in the pathogenic interaction between Rickettsia africae, endothelial cells, and platelets. ( 16888032 )
2006
32
African tick bite fever: a not-so-uncommon illness in international travelers. ( 17043186 )
2006
33
African tick bite fever. ( 17067925 )
2006
34
Histologic features and immunodetection of African tick-bite fever eschar. ( 17073080 )
2006
35
Cardiac involvement in a patient with clinical and serological evidence of African tick-bite fever. ( 16242016 )
2005
36
African tick-bite fever in French travelers. ( 16422013 )
2005
37
Comparison of immunofluorescence, Western blotting, and cross-adsorption assays for diagnosis of African tick bite fever. ( 15242958 )
2004
38
African tick-bite fever. ( 15301327 )
2004
39
African tick-bite fever: four cases among Swiss travelers returning from South Africa. ( 15541225 )
2004
40
African tick bite fever: not a spotless rickettsiosis! ( 12582376 )
2003
41
Systemic inflammatory responses in African tick-bite fever. ( 12696016 )
2003
42
African tick bite fever in travelers to rural sub-Equatorial Africa. ( 12766836 )
2003
43
Sequential changes in hematologic and biochemical parameters in African tick bite fever. ( 12925109 )
2003
44
African tick bite fever. ( 12954562 )
2003
45
Outbreak of African tick-bite fever in six Italian tourists returning from South Africa. ( 11939395 )
2002
46
African tick-bite fever in South Africa. ( 12379945 )
2002
47
Imported African tick bite fever: a case report. ( 10344666 )
1999
48
African tick-bite fever imported into Norway: presentation of 8 cases. ( 10447320 )
1999
49
African tick-bite fever among international travelers--Oregon, 1998. ( 9832471 )
1998
50
African tick-bite fever. An imported spotless rickettsiosis. ( 8996049 )
1997

Variations for African Tick-Bite Fever

Expression for African Tick-Bite Fever

Search GEO for disease gene expression data for African Tick-Bite Fever.

Pathways for African Tick-Bite Fever

GO Terms for African Tick-Bite Fever

Cellular components related to African Tick-Bite Fever according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.02 CCL5 CD40LG GPT IFNG SELE

Biological processes related to African Tick-Bite Fever according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.61 CCL5 CD40LG IFNG
2 regulation of signaling receptor activity GO:0010469 9.5 CCL5 CD40LG IFNG
3 response to virus GO:0009615 9.48 CCL5 IFNG
4 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.46 CCL5 IFNG
5 inflammatory response GO:0006954 9.43 CCL5 CD40LG SELE
6 regulation of insulin secretion GO:0050796 9.4 CCL5 IFNG
7 positive regulation of T cell proliferation GO:0042102 9.37 CCL5 CD40LG
8 response to tumor necrosis factor GO:0034612 9.16 CCL5 SELE
9 positive regulation of interleukin-12 production GO:0032735 8.96 CD40LG IFNG
10 leukocyte cell-cell adhesion GO:0007159 8.8 CCL5 CD40LG SELE

Molecular functions related to African Tick-Bite Fever according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 8.8 CCL5 CD40LG IFNG

Sources for African Tick-Bite Fever

3 CDC
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9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
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33 HPO
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35 ICD10 via Orphanet
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59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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