MCID: AFR002
MIFTS: 30

African Tick-Bite Fever

Categories: Infectious diseases

Aliases & Classifications for African Tick-Bite Fever

MalaCards integrated aliases for African Tick-Bite Fever:

Name: African Tick-Bite Fever 12 15
Rickettsia Africae Spotted Fever 12
South African Tick-Bite Fever 12
African Tick Bite Fever 72

Classifications:



External Ids:

Disease Ontology 12 DOID:0050035
UMLS 72 C1320317

Summaries for African Tick-Bite Fever

Disease Ontology : 12 A spotted fever that has material basis in Rickettsia africae, which is transmitted by ticks (Amblyomma hebraeum and Amblyomma variegatum). The infection has symptom fever, has symptom eschar and has symptom maculopapular rash.

MalaCards based summary : African Tick-Bite Fever, also known as rickettsia africae spotted fever, is related to epidemic typhus and meningoencephalitis, and has symptoms including fever, maculopapular rash and eschar. An important gene associated with African Tick-Bite Fever is CD40LG (CD40 Ligand), and among its related pathways/superpathways are Cell adhesion molecules (CAMs) and TNF signaling pathway. Affiliated tissues include skin and endothelial.

Wikipedia : 75 African tick bite fever (ATBF) is a bacterial infection spread by the bite of a tick. Symptoms may... more...

Related Diseases for African Tick-Bite Fever

Diseases related to African Tick-Bite Fever via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 68)
# Related Disease Score Top Affiliating Genes
1 epidemic typhus 30.2 GPT CCL5
2 meningoencephalitis 30.0 CD40LG CCL5
3 vasculitis 30.0 SELE CD40LG
4 boutonneuse fever 12.6
5 spotted fever 10.8
6 exanthem 10.8
7 lymphadenitis 10.5
8 lymphangitis 10.5
9 myocarditis 10.3
10 headache 10.3
11 kearns-sayre syndrome 10.2
12 kala-azar 1 10.2
13 ataxia, combined cerebellar and peripheral, with hearing loss and diabetes mellitus 10.2
14 sensorineural hearing loss 10.2
15 queensland tick typhus 10.2
16 erysipelas 10.2
17 pulmonary edema 10.2
18 pericarditis 10.2
19 cellulitis 10.2
20 acute myocarditis 10.2
21 internuclear ophthalmoplegia 10.2
22 lymphopenia 10.2
23 neuropathy 10.2
24 leishmaniasis 10.2
25 cutaneous leishmaniasis 10.2
26 stomatitis 10.2
27 aphthous stomatitis 10.2
28 encephalopathy 10.2
29 rickettsial disease 10.2
30 spotted fever rickettsiosis 10.2
31 hepatitis e 10.2 GPT CD40LG
32 immune deficiency disease 10.1 IL13 CD40LG
33 schistosomiasis 10.1 IL13 CD40LG
34 pustulosis palmaris et plantaris 10.1 SELE CD40LG
35 tetanus 10.1 IL13 CD40LG
36 actinic prurigo 10.0 SELE IL13
37 exposure keratitis 10.0 SELE IL13
38 fascioliasis 10.0 SELE GPT
39 antiphospholipid syndrome 10.0 SELE CD40LG
40 systemic scleroderma 9.9 SELE CD40LG
41 idiopathic neutropenia 9.9 CD40LG CCL5
42 respiratory syncytial virus infectious disease 9.9 IL13 CCL5
43 dengue disease 9.9 CD40LG CCL5
44 chronic conjunctivitis 9.8 IL13 CCL5
45 vernal keratoconjunctivitis 9.8 IL13 CCL5
46 stevens-johnson syndrome/toxic epidermal necrolysis 9.8 IL13 CCL5
47 pulmonary eosinophilia 9.8 IL13 CCL5
48 eosinophilic pneumonia 9.8 IL13 CCL5
49 onchocerciasis 9.8 IL13 CCL5
50 common cold 9.8 IL13 CCL5

Graphical network of the top 20 diseases related to African Tick-Bite Fever:



Diseases related to African Tick-Bite Fever

Symptoms & Phenotypes for African Tick-Bite Fever

Symptoms:

12
  • fever
  • maculopapular rash
  • eschar

Drugs & Therapeutics for African Tick-Bite Fever

Search Clinical Trials , NIH Clinical Center for African Tick-Bite Fever

Genetic Tests for African Tick-Bite Fever

Anatomical Context for African Tick-Bite Fever

MalaCards organs/tissues related to African Tick-Bite Fever:

41
Skin, Endothelial

Publications for African Tick-Bite Fever

Articles related to African Tick-Bite Fever:

(show top 50) (show all 132)
# Title Authors PMID Year
1
Seroprevalence of typhus group and spotted fever group Rickettsia exposures on Reunion island. 38
31288833 2019
2
African Tick-Bite Fever. 38
30855745 2019
3
Rickettsioses: Cutaneous findings frequently lead to diagnosis - a review. 38
30537329 2018
4
Under-diagnosis of rickettsial disease in clinical practice: A systematic review. 38
29486240 2018
5
Diagnosis of Spotted Fever Group Rickettsioses in U.S. Travelers Returning from Africa, 2007-2016. 38
29848404 2018
6
Update on Tick-Borne Bacterial Diseases in Travelers. 38
29789953 2018
7
Rickettsioses in Denmark: A retrospective survey of clinical features and travel history. 38
29415864 2018
8
First report of African tick-bite fever in a South American traveler. 38
29796268 2018
9
A Tale of Black Eschar in a Returning Traveller. 38
28988739 2017
10
African Tick Bite Fever Treated Successfully With Rifampin in a Patient With Doxycycline Intolerance. 38
28505276 2017
11
African tick-bite fever - a tantalizing souvenir from South Africa. 38
28872753 2017
12
Fever and Multiple Eschars After an African Safari: Report of Three Cases. 38
28544092 2017
13
African tick bite fever in returning Swedish travellers. Report of two cases and aspects of diagnostics. 38
28815000 2017
14
African Tick-Bite Fever in Traveler Returning to Slovenia from Uganda. 38
27648844 2016
15
Molecular diagnosis of African tick bite fever using eschar swabs in a traveller returning from Tanzania. 38
27488618 2016
16
Evidence of Rickettsia and Orientia Infections Among Abattoir Workers in Djibouti. 38
27273647 2016
17
Phylogenetic Variants of Rickettsia africae, and Incidental Identification of "Candidatus Rickettsia Moyalensis" in Kenya. 38
27387337 2016
18
African tick bite fever. 38
27929573 2016
19
Investigation of Rickettsia, Coxiella burnetii and Bartonella in ticks from animals in South Africa. 38
26718068 2016
20
A case of African tick-bite fever in a returning traveler. 38
27516971 2016
21
African tick-bite fever in a returning traveler. 38
25795527 2015
22
A family with African tick bite fever. 38
25886872 2015
23
Images in clinical medicine: African tick-bite fever after a game-hunting expedition. 38
25738687 2015
24
First case of imported African tick-bite fever in Poland - Case report. 38
26403104 2015
25
[Exanthems and fever in travellers returning from the tropics]. 38
25231591 2014
26
High prevalence of Rickettsia africae variants in Amblyomma variegatum ticks from domestic mammals in rural western Kenya: implications for human health. 38
25325312 2014
27
First molecular detection of Rickettsia africae in ticks from the Union of the Comoros. 38
25245895 2014
28
Rickettsioses and Q fever in travelers (2004-2013). 38
25262433 2014
29
[Papulovesicular exanthem after a safari in South Africa]. 38
24419477 2014
30
[South African tick bite fever in a group of Russian tourists]. 38
25715493 2014
31
Case report of African tick-bite fever from Poland. 38
24494003 2013
32
High prevalence of spotted fever group rickettsiae in Amblyomma variegatum from Uganda and their identification using sizes of intergenic spacers. 38
24331642 2013
33
Black spots in the returning traveler. 38
24314770 2013
34
Rickettsial infections in the tropics and in the traveler. 38
23842049 2013
35
Tick-borne rickettsioses in Europe. 38
23177355 2012
36
Rickettsia africae in Hyalomma dromedarii ticks from sub-Saharan Algeria. 38
23164496 2012
37
The use of eschar swabs for the diagnosis of African tick-bite fever. 38
23141102 2012
38
Cutaneous leishmaniasis and rickettsial African tick-bite fever: a combination of exotic traveler's diseases in the same patient. 38
22788813 2012
39
[Vacation and tropical dermatoses]. 38
22532262 2012
40
[African tick bite fever--rickettsiosis after holiday in South Africa]. 38
22511280 2012
41
Molecular diagnostics of Rickettsia africae infection in travelers returning from South Africa to The Netherlands. 38
21867422 2011
42
[African Tick Bite Fever upon game hunting in South Africa]. 38
21985836 2011
43
Neurological picture. Internuclear ophthalmoplegia following African tick bite fever. 38
21421770 2011
44
Risk factors for African tick-bite fever in rural central Africa. 38
21460018 2011
45
Emergence of Rickettsia africae, Oceania. 38
21192865 2011
46
Rickettsia africae in Amblyomma variegatum and domestic ruminants on eight Caribbean islands. 38
21158615 2010
47
[Rickettsia africae infection among participants in a women's safari to South Africa]. 38
21302470 2010
48
African tick-bite fever: a new entity in the differential diagnosis of multiple eschars in travelers. Description of five cases imported from South Africa to Switzerland. 38
20233665 2010
49
[Tick bite fever in West Africa: difficulties in diagnosis of an emerging disease]. 38
20099678 2009
50
Unusual location of an inoculation lesion in a traveler with African tick-bite fever returning from South Africa. 38
19930389 2009

Variations for African Tick-Bite Fever

Expression for African Tick-Bite Fever

Search GEO for disease gene expression data for African Tick-Bite Fever.

Pathways for African Tick-Bite Fever

GO Terms for African Tick-Bite Fever

Cellular components related to African Tick-Bite Fever according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.02 SELE IL13 GPT CD40LG CCL5

Biological processes related to African Tick-Bite Fever according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.54 IL13 CD40LG CCL5
2 response to lipopolysaccharide GO:0032496 9.43 SELE IL13
3 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.4 IL13 CCL5
4 positive regulation of T cell proliferation GO:0042102 9.32 CD40LG CCL5
5 positive regulation of smooth muscle cell proliferation GO:0048661 9.26 IL13 CCL5
6 inflammatory response GO:0006954 9.26 SELE IL13 CD40LG CCL5
7 response to tumor necrosis factor GO:0034612 9.16 SELE CCL5
8 leukocyte cell-cell adhesion GO:0007159 8.8 SELE CD40LG CCL5

Molecular functions related to African Tick-Bite Fever according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 8.8 IL13 CD40LG CCL5

Sources for African Tick-Bite Fever

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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