MCID: AFR002
MIFTS: 37

African Tick-Bite Fever

Categories: Infectious diseases

Aliases & Classifications for African Tick-Bite Fever

MalaCards integrated aliases for African Tick-Bite Fever:

Name: African Tick-Bite Fever 12 15
Rickettsia Africae Spotted Fever 12
South African Tick-Bite Fever 12
African Tick Bite Fever 71

Classifications:



External Ids:

Disease Ontology 12 DOID:0050035
UMLS 71 C1320317

Summaries for African Tick-Bite Fever

Disease Ontology : 12 A spotted fever that has material basis in Rickettsia africae, which is transmitted by ticks (Amblyomma hebraeum and Amblyomma variegatum). The infection has symptom fever, has symptom eschar and has symptom maculopapular rash.

MalaCards based summary : African Tick-Bite Fever, also known as rickettsia africae spotted fever, is related to spotted fever and lymphadenitis, and has symptoms including fever, maculopapular rash and eschar. An important gene associated with African Tick-Bite Fever is SELE (Selectin E), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. Affiliated tissues include endothelial, and related phenotypes are cellular and hematopoietic system

Wikipedia : 74 African tick bite fever (ATBF) is a bacterial infection spread by the bite of a tick. Symptoms may... more...

Related Diseases for African Tick-Bite Fever

Diseases related to African Tick-Bite Fever via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 612)
# Related Disease Score Top Affiliating Genes
1 spotted fever 30.3 VWF TNF IL10 IFNG CCL5
2 lymphadenitis 30.3 TNF IL10 IFNG
3 epidemic typhus 30.1 TNF IL10 GPT CCL5
4 erysipelas 30.0 TNF IL6
5 cellulitis 30.0 TNF IL6 GPT
6 exanthem 30.0 TNF IL6 IL10 IFNG GPT
7 pulmonary edema 30.0 TNF IL13 IL10
8 lymphopenia 29.8 IL6 IL10 IFNG
9 pericarditis 29.7 TNF IL6 IFNG
10 spotted fever rickettsiosis 29.6 TNF IL10 IFNG CCL5
11 vasculitis 29.6 VWF TNF SELE IL6 CD40LG
12 meningoencephalitis 29.6 TNF IL6 IL10 CD40LG CCL5
13 stomatitis 29.5 TNF IL6 IL10 IFNG
14 aphthous stomatitis 29.3 TNF SELE IL6 IL10 IFNG
15 disease by infectious agent 29.2 TNF IL6 IL10 IFNG GPT CCL3
16 myocarditis 29.2 TNF IL6 IL10 IFNG CD40LG CCL3
17 cutaneous leishmaniasis 29.0 TNF IL6 IL13 IL10 IFNG
18 leishmaniasis 29.0 TNF IL6 IL13 IL10 IFNG
19 boutonneuse fever 11.6
20 lymphangitis 10.4
21 allergic encephalomyelitis 10.3 CCL5 CCL3
22 inflammatory bowel disease 16 10.3 CD40LG CCL3
23 whiplash 10.3 CCL5 CCL3
24 type 1 diabetes mellitus 22 10.3 CCL5 CCL3
25 rickettsial disease 10.3
26 heterophyiasis 10.3 SELE GPT
27 methotrexate toxicity 10.2 SELE GPT
28 toxicodendron dermatitis 10.2 TNF SELE
29 mycetoma 10.2 IL10 CCL5
30 punctate inner choroidopathy 10.2 TNF IL10
31 tropical endomyocardial fibrosis 10.2 TNF IL10
32 endomyocardial fibrosis 10.2 TNF IL10
33 autoimmune hepatitis type 1 10.2 IL10 GPT
34 inflammatory and toxic neuropathy 10.2 TNF SELE
35 multifocal choroiditis 10.2 TNF IL10
36 acute transverse myelitis 10.2 IL6 IL10
37 rheumatoid vasculitis 10.2 TNF SELE
38 basidiobolomycosis 10.2 IL10 GPT
39 shwartzman phenomenon 10.2 TNF SELE
40 near-fatal asthma 10.2 TNF CCL5
41 acute gonococcal cervicitis 10.2 IL6 IL10
42 vulvovaginitis 10.2 IL10 CCL5
43 obesity-hypoventilation syndrome 10.2 IL6 CCL5
44 eye lymphoma 10.2 IL6 IL10
45 acute retinal necrosis syndrome 10.2 IL6 IL10
46 tertiary syphilis 10.2 TNF IL10
47 anaerobic pneumonia 10.2 IL6 CCL5
48 chemical colitis 10.2 TNF IL10
49 tuberculous meningitis 10.1 TNF CCL3
50 transient hypogammaglobulinemia 10.1 TNF IL10

Graphical network of the top 20 diseases related to African Tick-Bite Fever:



Diseases related to African Tick-Bite Fever

Symptoms & Phenotypes for African Tick-Bite Fever

Symptoms:

12
  • fever
  • maculopapular rash
  • eschar

MGI Mouse Phenotypes related to African Tick-Bite Fever:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.01 CD40LG IFNG IL10 IL13 IL6 SELE
2 hematopoietic system MP:0005397 9.97 CCL5 CD40LG IFNG IL10 IL13 IL6
3 immune system MP:0005387 9.91 CCL5 CD40LG IFNG IL10 IL13 IL6
4 digestive/alimentary MP:0005381 9.85 IFNG IL10 IL13 IL6 TNF VWF
5 integument MP:0010771 9.7 CD40LG IFNG IL10 IL13 IL6 SELE
6 respiratory system MP:0005388 9.43 IFNG IL10 IL13 IL6 SELE TNF
7 skeleton MP:0005390 9.17 CD40LG GPT IFNG IL10 IL13 IL6

Drugs & Therapeutics for African Tick-Bite Fever

Search Clinical Trials , NIH Clinical Center for African Tick-Bite Fever

Genetic Tests for African Tick-Bite Fever

Anatomical Context for African Tick-Bite Fever

MalaCards organs/tissues related to African Tick-Bite Fever:

40
Endothelial

Publications for African Tick-Bite Fever

Articles related to African Tick-Bite Fever:

(show top 50) (show all 139)
# Title Authors PMID Year
1
African Tick Bite Fever: First imported cases diagnosed by PCR in Argentina. 61
33387687 2020
2
Genetic diversity of Rickettsia africae isolates from Amblyomma hebraeum and blood from cattle in the Eastern Cape province of South Africa. 61
33025239 2020
3
African Tick-Bite Fever. 61
32325042 2020
4
Rickettsia africae an Agent of African Tick Bite Fever in Ticks Collected from Domestic Animals in Eastern Cape, South Africa. 61
32748891 2020
5
A Case of African Tick-Bite Fever in a Returning Traveler from Southern Africa. 61
32757495 2020
6
Molecular detection of Rickettsia africae in Amblyomma ticks collected in cattle from Southern and Central Mozambique. 61
32683352 2020
7
Probable African Tick Bite Fever in the United States. 61
32226336 2020
8
Pathogens, endosymbionts, and blood-meal sources of host-seeking ticks in the fast-changing Maasai Mara wildlife ecosystem. 61
32866142 2020
9
Seroprevalence of typhus group and spotted fever group Rickettsia exposures on Reunion island. 61
31288833 2019
10
South African Tick Bite Fever: An Overview. 61
31700846 2019
11
African Tick-Bite Fever. 61
30855745 2019
12
Rickettsioses: Cutaneous findings frequently lead to diagnosis - a review. 61
30537329 2018
13
Under-diagnosis of rickettsial disease in clinical practice: A systematic review. 61
29486240 2018
14
Diagnosis of Spotted Fever Group Rickettsioses in U.S. Travelers Returning from Africa, 2007-2016. 61
29848404 2018
15
Update on Tick-Borne Bacterial Diseases in Travelers. 61
29789953 2018
16
Rickettsioses in Denmark: A retrospective survey of clinical features and travel history. 61
29415864 2018
17
First report of African tick-bite fever in a South American traveler. 61
29796268 2018
18
A Tale of Black Eschar in a Returning Traveller. 61
28988739 2017
19
African tick-bite fever - a tantalizing souvenir from South Africa. 61
28872753 2017
20
African Tick Bite Fever Treated Successfully With Rifampin in a Patient With Doxycycline Intolerance. 61
28505276 2017
21
Fever and Multiple Eschars After an African Safari: Report of Three Cases. 61
28544092 2017
22
African tick bite fever in returning Swedish travellers. Report of two cases and aspects of diagnostics. 61
28815000 2017
23
African Tick-Bite Fever in Traveler Returning to Slovenia from Uganda. 61
27648844 2016
24
Evidence of Rickettsia and Orientia Infections Among Abattoir Workers in Djibouti. 61
27273647 2016
25
Molecular diagnosis of African tick bite fever using eschar swabs in a traveller returning from Tanzania. 61
27488618 2016
26
Phylogenetic Variants of Rickettsia africae, and Incidental Identification of "Candidatus Rickettsia Moyalensis" in Kenya. 61
27387337 2016
27
African tick bite fever. 61
27929573 2016
28
Investigation of Rickettsia, Coxiella burnetii and Bartonella in ticks from animals in South Africa. 61
26718068 2016
29
A case of African tick-bite fever in a returning traveler. 61
27516971 2016
30
African tick-bite fever in a returning traveler. 61
25795527 2015
31
A family with African tick bite fever. 61
25886872 2015
32
Images in clinical medicine: African tick-bite fever after a game-hunting expedition. 61
25738687 2015
33
First case of imported African tick-bite fever in Poland - Case report. 61
26403104 2015
34
High prevalence of Rickettsia africae variants in Amblyomma variegatum ticks from domestic mammals in rural western Kenya: implications for human health. 61
25325312 2014
35
[Exanthems and fever in travellers returning from the tropics]. 61
25231591 2014
36
Rickettsioses and Q fever in travelers (2004-2013). 61
25262433 2014
37
First molecular detection of Rickettsia africae in ticks from the Union of the Comoros. 61
25245895 2014
38
[Papulovesicular exanthem after a safari in South Africa]. 61
24419477 2014
39
[South African tick bite fever in a group of Russian tourists]. 61
25715493 2014
40
High prevalence of spotted fever group rickettsiae in Amblyomma variegatum from Uganda and their identification using sizes of intergenic spacers. 61
24331642 2013
41
Case report of African tick-bite fever from Poland. 61
24494003 2013
42
Black spots in the returning traveler. 61
24314770 2013
43
Rickettsial infections in the tropics and in the traveler. 61
23842049 2013
44
Tick-borne rickettsioses in Europe. 61
23177355 2012
45
Rickettsia africae in Hyalomma dromedarii ticks from sub-Saharan Algeria. 61
23164496 2012
46
The use of eschar swabs for the diagnosis of African tick-bite fever. 61
23141102 2012
47
Cutaneous leishmaniasis and rickettsial African tick-bite fever: a combination of exotic traveler's diseases in the same patient. 61
22788813 2012
48
[Vacation and tropical dermatoses]. 61
22532262 2012
49
[African tick bite fever--rickettsiosis after holiday in South Africa]. 61
22511280 2012
50
Molecular diagnostics of Rickettsia africae infection in travelers returning from South Africa to The Netherlands. 61
21867422 2011

Variations for African Tick-Bite Fever

Expression for African Tick-Bite Fever

Search GEO for disease gene expression data for African Tick-Bite Fever.

Pathways for African Tick-Bite Fever

Pathways related to African Tick-Bite Fever according to GeneCards Suite gene sharing:

(show top 50) (show all 62)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.93 VWF TNF IL6 IL13 IL10 IFNG
2
Show member pathways
13.72 TNF IL6 IL13 IL10 CD40LG CCL5
3
Show member pathways
13.59 TNF IL6 IL13 IL10 IFNG CD40LG
4
Show member pathways
13.47 TNF IL6 IL13 IL10 IFNG CCL5
5
Show member pathways
13.34 TNF IL6 IL13 IL10 CD40LG CCL5
6
Show member pathways
13.2 TNF IL6 IL13 IL10 CD40LG CCL5
7
Show member pathways
13.17 VWF TNF IL6 IL13 IL10 IFNG
8
Show member pathways
13.01 TNF IL6 IL10 IFNG CCL5 CCL3
9
Show member pathways
12.78 TNF IL6 IL13 IL10 IFNG CD40LG
10
Show member pathways
12.74 TNF IL6 IFNG CCL5
11 12.72 TNF IL6 IFNG CCL5
12
Show member pathways
12.58 TNF IL6 IL10 IFNG CD40LG
13
Show member pathways
12.57 TNF IL10 IFNG CD40LG
14
Show member pathways
12.57 TNF IL6 IL13 IL10 IFNG
15
Show member pathways
12.53 TNF IL6 IL10 IFNG
16 12.53 TNF IL10 IFNG CD40LG CCL5
17
Show member pathways
12.39 IL6 IL13 IL10 IFNG
18
Show member pathways
12.32 TNF IL6 IL13 IFNG
19
Show member pathways
12.31 TNF IL6 IFNG CCL5
20
Show member pathways
12.27 TNF IL6 IL10 CCL5 CCL3
21
Show member pathways
12.25 TNF IL10 IFNG CD40LG
22
Show member pathways
12.23 TNF IL6 IL13 IL10 IFNG
23 12.22 TNF IL6 IL10 IFNG
24 12.17 TNF IL6 IL13 IL10
25 12.12 TNF IL6 IFNG
26
Show member pathways
12.12 TNF IL6 IFNG
27 12.04 TNF SELE IFNG
28 12.03 TNF IL6 IL10
29 11.98 TNF IL6 IL10 IFNG
30 11.97 TNF IL6 IFNG
31 11.96 TNF IL6 IL13 IL10
32 11.95 TNF SELE IL6 CCL5
33 11.91 IL6 IFNG CCL3
34 11.89 TNF IL6 IL10 IFNG
35 11.88 TNF SELE IL6
36 11.82 TNF IL6 IFNG CCL5 CCL3
37 11.79 SELE IL6 IL13 IFNG
38 11.75 TNF IL6 IL10
39
Show member pathways
11.75 TNF IFNG CD40LG
40
Show member pathways
11.75 TNF IL6 IL10 IFNG
41 11.73 TNF IL13 IL10 IFNG CCL3
42 11.72 TNF IL6 IL10 IFNG
43 11.64 TNF IL6 IL10 CD40LG
44 11.6 SELE IL6 IFNG
45
Show member pathways
11.57 TNF SELE IL6 IFNG CD40LG
46 11.56 TNF IL6 IFNG
47 11.52 TNF IL6 IL13 CCL5 CCL3
48 11.51 IL13 IL10 IFNG
49 11.5 TNF IL6 IFNG
50 11.37 TNF IL6 IL10

GO Terms for African Tick-Bite Fever

Cellular components related to African Tick-Bite Fever according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.61 VWF TNF IL6 IL13 IL10 IFNG
2 extracellular space GO:0005615 9.36 VWF TNF SELE IL6 IL13 IL10

Biological processes related to African Tick-Bite Fever according to GeneCards Suite gene sharing:

(show top 50) (show all 54)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 9.99 TNF IL6 IL13 IFNG CCL3
2 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.89 TNF IL6 CD40LG
3 response to virus GO:0009615 9.86 TNF IFNG CCL5
4 positive regulation of DNA-binding transcription factor activity GO:0051091 9.85 TNF IL6 IL10
5 platelet activation GO:0030168 9.85 VWF IL6 CD40LG
6 positive regulation of inflammatory response GO:0050729 9.84 TNF IFNG CCL3
7 positive regulation of interleukin-6 production GO:0032755 9.83 TNF IL6 IFNG
8 positive regulation of tumor necrosis factor production GO:0032760 9.82 IL6 IFNG CCL3
9 cellular response to organic cyclic compound GO:0071407 9.81 TNF CCL5 CCL3
10 cytokine-mediated signaling pathway GO:0019221 9.8 TNF IL6 IL13 IL10 CCL5 CCL3
11 response to glucocorticoid GO:0051384 9.79 TNF IL6 IL10
12 positive regulation of T cell proliferation GO:0042102 9.79 IL6 CD40LG CCL5
13 humoral immune response GO:0006959 9.78 TNF IL6 IFNG
14 positive regulation of cytokine production GO:0001819 9.77 TNF IL10 IFNG
15 monocyte chemotaxis GO:0002548 9.76 IL6 CCL5 CCL3
16 protein kinase B signaling GO:0043491 9.74 TNF CCL5 CCL3
17 positive regulation of chemokine production GO:0032722 9.73 TNF IL6 IFNG
18 regulation of insulin secretion GO:0050796 9.73 TNF IL6 IFNG CCL5
19 positive regulation of osteoclast differentiation GO:0045672 9.72 TNF IFNG
20 positive regulation of interleukin-10 production GO:0032733 9.72 IL6 IL13 CD40LG
21 positive regulation of amyloid-beta formation GO:1902004 9.71 TNF IFNG
22 leukocyte tethering or rolling GO:0050901 9.71 TNF SELE
23 positive regulation of macrophage activation GO:0043032 9.71 IL13 IL10
24 positive regulation of glial cell proliferation GO:0060252 9.71 TNF IL6
25 lipopolysaccharide-mediated signaling pathway GO:0031663 9.71 TNF CCL5 CCL3
26 positive regulation of smooth muscle cell proliferation GO:0048661 9.71 TNF IL6 IL13 CCL5
27 eosinophil chemotaxis GO:0048245 9.7 CCL5 CCL3
28 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.7 TNF IFNG
29 astrocyte activation GO:0048143 9.7 TNF IFNG
30 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.7 TNF IL10
31 positive regulation of leukocyte adhesion to vascular endothelial cell GO:1904996 9.69 TNF IL6
32 macrophage chemotaxis GO:0048246 9.69 CCL5 CCL3
33 positive regulation of signaling receptor activity GO:2000273 9.68 IL10 IFNG
34 negative regulation by host of viral transcription GO:0043922 9.68 CCL5 CCL3
35 positive regulation of neuroinflammatory response GO:0150078 9.68 TNF IL6
36 negative regulation of amyloid-beta clearance GO:1900222 9.67 TNF IFNG
37 positive regulation of MHC class II biosynthetic process GO:0045348 9.67 IL10 IFNG
38 leukocyte cell-cell adhesion GO:0007159 9.67 SELE CD40LG CCL5
39 positive regulation of interleukin-1 beta production GO:0032731 9.67 TNF IL6 IFNG CCL3
40 negative regulation of lipid storage GO:0010888 9.65 TNF IL6
41 regulation of immunoglobulin production GO:0002637 9.65 TNF CD40LG
42 microglial cell activation GO:0001774 9.65 TNF IL13 IFNG
43 endothelial cell apoptotic process GO:0072577 9.64 TNF IL10
44 vascular endothelial growth factor production GO:0010573 9.64 TNF IL6
45 positive regulation of natural killer cell chemotaxis GO:2000503 9.63 CCL5 CCL3
46 positive regulation of immunoglobulin production GO:0002639 9.63 IL6 IL13 IL10
47 negative regulation of cytokine production involved in immune response GO:0002719 9.62 TNF IL10
48 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.58 TNF IFNG
49 positive regulation of JAK-STAT cascade GO:0046427 9.56 TNF IL6 IL10 CCL5
50 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.55 TNF IL6 IL13 IFNG CCL5

Molecular functions related to African Tick-Bite Fever according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 CCR5 chemokine receptor binding GO:0031730 9.26 CCL5 CCL3
2 cytokine activity GO:0005125 9.23 TNF IL6 IL13 IL10 IFNG CD40LG
3 phospholipase activator activity GO:0016004 9.16 CCL5 CCL3
4 CCR1 chemokine receptor binding GO:0031726 8.96 CCL5 CCL3

Sources for African Tick-Bite Fever

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
Content
Loading form....