MCID: AFR002
MIFTS: 37

African Tick-Bite Fever

Categories: Infectious diseases

Aliases & Classifications for African Tick-Bite Fever

MalaCards integrated aliases for African Tick-Bite Fever:

Name: African Tick-Bite Fever 12 15
Rickettsia Africae Spotted Fever 12
South African Tick-Bite Fever 12
African Tick Bite Fever 71

Classifications:



External Ids:

Disease Ontology 12 DOID:0050035
UMLS 71 C1320317

Summaries for African Tick-Bite Fever

Disease Ontology : 12 A spotted fever that has material basis in Rickettsia africae, which is transmitted by ticks (Amblyomma hebraeum and Amblyomma variegatum). The infection has symptom fever, has symptom eschar and has symptom maculopapular rash.

MalaCards based summary : African Tick-Bite Fever, also known as rickettsia africae spotted fever, is related to boutonneuse fever and lymphadenitis, and has symptoms including fever, maculopapular rash and eschar. An important gene associated with African Tick-Bite Fever is CD40LG (CD40 Ligand), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. Affiliated tissues include skin and endothelial, and related phenotypes are hematopoietic system and immune system

Wikipedia : 74 African tick bite fever (ATBF) is a bacterial infection spread by the bite of a tick. Symptoms may... more...

Related Diseases for African Tick-Bite Fever

Diseases related to African Tick-Bite Fever via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 604)
# Related Disease Score Top Affiliating Genes
1 boutonneuse fever 34.1 SELE CS CD40LG
2 lymphadenitis 30.0 TNF IL10 IFNG
3 erysipelas 29.9 TNF IL6 CD40LG
4 epidemic typhus 29.8 IL10 GPT CS CD40LG CCL5
5 lymphopenia 29.7 IL6 IL10 IFNG
6 pulmonary edema 29.7 TNF IL13 IL10
7 exanthem 29.3 TNF IL6 IL10 IFNG GPT CD40LG
8 spotted fever rickettsiosis 29.3 TNF IL10 IFNG CCL5
9 pericarditis 29.2 TNF IL6 IFNG CD40LG
10 meningoencephalitis 29.2 TNF IL6 IL10 CD40LG CCL5
11 spotted fever 29.0 VWF TNF IL10 IFNG CS CD40LG
12 stomatitis 28.9 TNF IL6 IL10 IFNG CD40LG
13 cellulitis 28.9 TNF IL6 IL10 IFNG CD40LG
14 aphthous stomatitis 28.9 TNF SELE IL6 IL10 IFNG
15 vasculitis 28.8 VWF TNF SELE IL6 IL10 CD40LG
16 myocarditis 28.8 TNF IL6 IL10 IFNG CD40LG CCL3
17 cutaneous leishmaniasis 28.6 TNF IL6 IL13 IL10 IFNG
18 leishmaniasis 28.1 TNF IL6 IL13 IL10 IFNG GPT
19 lymphangitis 10.5
20 astrakhan spotted fever 10.4 CD40LG CCL5
21 allergic encephalomyelitis 10.4 CCL5 CCL3
22 whiplash 10.4 CCL5 CCL3
23 diabetes mellitus, insulin-dependent, 22 10.4 CCL5 CCL3
24 splenic abscess 10.3 GPT CD40LG
25 headache 10.3
26 rickettsial disease 10.3
27 endocrine exophthalmos 10.3 IL6 CD40LG
28 acalculous cholecystitis 10.3 GPT CD40LG
29 viral laryngitis 10.3 GPT CD40LG
30 autoimmune hepatitis type 1 10.3 IL10 GPT
31 acute transverse myelitis 10.3 IL6 IL10
32 methotrexate toxicity 10.3 SELE GPT
33 splenic sequestration 10.3 VWF CD40LG
34 obesity-hypoventilation syndrome 10.3 IL6 CCL5
35 japanese spotted fever 10.3 CS CD40LG
36 diabetic peripheral angiopathy 10.3 SELE IL13
37 mycetoma 10.3 IL10 CCL5
38 maxillary sinusitis 10.3 CD40LG CCL5
39 neuroretinitis 10.3 CS CD40LG
40 eye lymphoma 10.3 IL6 IL10
41 splenic infarction 10.2 GPT CD40LG
42 toxocariasis 10.2 IL10 CD40LG
43 bacillary angiomatosis 10.2 CS CD40LG
44 brawny scleritis 10.2 IFNG CD40LG
45 heterophyiasis 10.2 SELE GPT CD40LG
46 genital herpes 10.2 IL10 CD40LG CCL5
47 primary thrombocytopenia 10.2 VWF IL10 CD40LG
48 thrombotic thrombocytopenic purpura 10.2 VWF SELE CD40LG
49 cat-scratch disease 10.2 CS CD40LG
50 traumatic brain injury 10.2 IL6 IL10

Graphical network of the top 20 diseases related to African Tick-Bite Fever:



Diseases related to African Tick-Bite Fever

Symptoms & Phenotypes for African Tick-Bite Fever

Symptoms:

12
  • fever
  • maculopapular rash
  • eschar

MGI Mouse Phenotypes related to African Tick-Bite Fever:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.91 CCL5 CD40LG IFNG IL10 IL13 IL6
2 immune system MP:0005387 9.81 CCL5 CD40LG IFNG IL10 IL13 IL6
3 digestive/alimentary MP:0005381 9.8 IFNG IL10 IL13 IL6 TNF VWF
4 integument MP:0010771 9.5 CD40LG IFNG IL10 IL13 IL6 SELE
5 respiratory system MP:0005388 9.1 IFNG IL10 IL13 IL6 SELE TNF

Drugs & Therapeutics for African Tick-Bite Fever

Search Clinical Trials , NIH Clinical Center for African Tick-Bite Fever

Genetic Tests for African Tick-Bite Fever

Anatomical Context for African Tick-Bite Fever

MalaCards organs/tissues related to African Tick-Bite Fever:

40
Skin, Endothelial

Publications for African Tick-Bite Fever

Articles related to African Tick-Bite Fever:

(show top 50) (show all 135)
# Title Authors PMID Year
1
African Tick-Bite Fever. 61
32325042 2020
2
Probable African Tick Bite Fever in the United States. 61
32226336 2020
3
Seroprevalence of typhus group and spotted fever group Rickettsia exposures on Reunion island. 61
31288833 2019
4
South African Tick Bite Fever: An Overview. 61
31700846 2019
5
African Tick-Bite Fever. 61
30855745 2019
6
Rickettsioses: Cutaneous findings frequently lead to diagnosis - a review. 61
30537329 2018
7
Under-diagnosis of rickettsial disease in clinical practice: A systematic review. 61
29486240 2018
8
Diagnosis of Spotted Fever Group Rickettsioses in U.S. Travelers Returning from Africa, 2007-2016. 61
29848404 2018
9
Update on Tick-Borne Bacterial Diseases in Travelers. 61
29789953 2018
10
Rickettsioses in Denmark: A retrospective survey of clinical features and travel history. 61
29415864 2018
11
First report of African tick-bite fever in a South American traveler. 61
29796268 2018
12
A Tale of Black Eschar in a Returning Traveller. 61
28988739 2017
13
African Tick Bite Fever Treated Successfully With Rifampin in a Patient With Doxycycline Intolerance. 61
28505276 2017
14
African tick-bite fever - a tantalizing souvenir from South Africa. 61
28872753 2017
15
Fever and Multiple Eschars After an African Safari: Report of Three Cases. 61
28544092 2017
16
African tick bite fever in returning Swedish travellers. Report of two cases and aspects of diagnostics. 61
28815000 2017
17
African Tick-Bite Fever in Traveler Returning to Slovenia from Uganda. 61
27648844 2016
18
Molecular diagnosis of African tick bite fever using eschar swabs in a traveller returning from Tanzania. 61
27488618 2016
19
Evidence of Rickettsia and Orientia Infections Among Abattoir Workers in Djibouti. 61
27273647 2016
20
Phylogenetic Variants of Rickettsia africae, and Incidental Identification of "Candidatus Rickettsia Moyalensis" in Kenya. 61
27387337 2016
21
African tick bite fever. 61
27929573 2016
22
Investigation of Rickettsia, Coxiella burnetii and Bartonella in ticks from animals in South Africa. 61
26718068 2016
23
A case of African tick-bite fever in a returning traveler. 61
27516971 2016
24
A family with African tick bite fever. 61
25886872 2015
25
African tick-bite fever in a returning traveler. 61
25795527 2015
26
Images in clinical medicine: African tick-bite fever after a game-hunting expedition. 61
25738687 2015
27
First case of imported African tick-bite fever in Poland - Case report. 61
26403104 2015
28
High prevalence of Rickettsia africae variants in Amblyomma variegatum ticks from domestic mammals in rural western Kenya: implications for human health. 61
25325312 2014
29
[Exanthems and fever in travellers returning from the tropics]. 61
25231591 2014
30
Rickettsioses and Q fever in travelers (2004-2013). 61
25262433 2014
31
First molecular detection of Rickettsia africae in ticks from the Union of the Comoros. 61
25245895 2014
32
[Papulovesicular exanthem after a safari in South Africa]. 61
24419477 2014
33
[South African tick bite fever in a group of Russian tourists]. 61
25715493 2014
34
Case report of African tick-bite fever from Poland. 61
24494003 2013
35
High prevalence of spotted fever group rickettsiae in Amblyomma variegatum from Uganda and their identification using sizes of intergenic spacers. 61
24331642 2013
36
Black spots in the returning traveler. 61
24314770 2013
37
Rickettsial infections in the tropics and in the traveler. 61
23842049 2013
38
Rickettsia africae in Hyalomma dromedarii ticks from sub-Saharan Algeria. 61
23164496 2012
39
Tick-borne rickettsioses in Europe. 61
23177355 2012
40
The use of eschar swabs for the diagnosis of African tick-bite fever. 61
23141102 2012
41
Cutaneous leishmaniasis and rickettsial African tick-bite fever: a combination of exotic traveler's diseases in the same patient. 61
22788813 2012
42
[Vacation and tropical dermatoses]. 61
22532262 2012
43
[African tick bite fever--rickettsiosis after holiday in South Africa]. 61
22511280 2012
44
Molecular diagnostics of Rickettsia africae infection in travelers returning from South Africa to The Netherlands. 61
21867422 2011
45
[African Tick Bite Fever upon game hunting in South Africa]. 61
21985836 2011
46
Neurological picture. Internuclear ophthalmoplegia following African tick bite fever. 61
21421770 2011
47
Risk factors for African tick-bite fever in rural central Africa. 61
21460018 2011
48
Emergence of Rickettsia africae, Oceania. 61
21192865 2011
49
Rickettsia africae in Amblyomma variegatum and domestic ruminants on eight Caribbean islands. 61
21158615 2010
50
[Rickettsia africae infection among participants in a women's safari to South Africa]. 61
21302470 2010

Variations for African Tick-Bite Fever

Expression for African Tick-Bite Fever

Search GEO for disease gene expression data for African Tick-Bite Fever.

Pathways for African Tick-Bite Fever

Pathways related to African Tick-Bite Fever according to GeneCards Suite gene sharing:

(show top 50) (show all 56)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.93 VWF TNF IL6 IL13 IL10 IFNG
2
Show member pathways
13.73 TNF IL6 IL13 IL10 CD40LG CCL5
3
Show member pathways
13.6 TNF IL6 IL13 IL10 IFNG CD40LG
4
Show member pathways
13.47 TNF IL6 IL13 IL10 IFNG CCL5
5
Show member pathways
13.34 TNF IL6 IL13 IL10 CD40LG CCL5
6
Show member pathways
13.22 TNF IL6 IL13 IL10 CD40LG CCL5
7
Show member pathways
13.2 VWF TNF IL6 IL13 IL10 IFNG
8
Show member pathways
13 TNF IL6 IL10 IFNG CCL5 CCL3
9
Show member pathways
12.77 TNF IL6 IL13 IL10 IFNG CD40LG
10
Show member pathways
12.57 TNF IL10 IFNG CD40LG
11
Show member pathways
12.57 TNF IL6 IL10 IFNG CD40LG
12
Show member pathways
12.56 TNF IL6 IL13 IL10 IFNG
13
Show member pathways
12.53 TNF IL6 IL10 IFNG
14 12.53 TNF IL10 IFNG CD40LG CCL5
15
Show member pathways
12.4 IL6 IL13 IL10 IFNG
16
Show member pathways
12.32 TNF IL6 IL13 IFNG
17
Show member pathways
12.31 TNF IL6 IFNG CCL5
18
Show member pathways
12.26 TNF IL6 IL10 CCL5 CCL3
19
Show member pathways
12.25 TNF IL10 IFNG CD40LG
20
Show member pathways
12.23 TNF IL6 IL13 IL10 IFNG
21 12.21 TNF IL6 IL10 IFNG
22 12.16 TNF IL6 IL13 IL10
23 12.04 TNF SELE IFNG
24 11.96 TNF IL6 IL10
25 11.96 TNF IL6 IFNG
26 11.96 TNF IL6 IL10 IFNG
27 11.95 TNF IL6 IL13 IL10
28 11.93 TNF SELE IL6 CCL5
29 11.91 IL6 IFNG CCL3
30
Show member pathways
11.9 TNF IL6 IL10 IFNG
31 11.88 TNF IL6 IL10 IFNG
32 11.87 TNF SELE IL6
33 11.82 TNF IL6 IFNG CCL5 CCL3
34 11.77 SELE IL6 IL13 IFNG
35 11.75 TNF IL6 IL10
36
Show member pathways
11.75 TNF IFNG CD40LG
37 11.71 TNF IL6 IL10 IFNG
38 11.71 TNF IL13 IL10 IFNG CCL3
39 11.59 SELE IL6 IFNG
40
Show member pathways
11.57 TNF SELE IL6 IFNG CD40LG
41 11.56 TNF IL6 IFNG
42 11.52 TNF IL6 IL13 CCL5 CCL3
43 11.5 IL13 IL10 IFNG
44 11.49 TNF IL6 IFNG
45
Show member pathways
11.37 TNF IL10 IFNG CCL3
46 11.36 TNF IL6 IL10
47 11.28 TNF IL6 IL13 IFNG
48 11.22 TNF SELE IL6 IL10 IFNG
49 11.2 IL13 IL10 IFNG
50 11.13 TNF SELE IL6 IL10 IFNG CD40LG

GO Terms for African Tick-Bite Fever

Cellular components related to African Tick-Bite Fever according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.61 VWF TNF IL6 IL13 IL10 IFNG
2 extracellular space GO:0005615 9.32 TNF SELE IL6 IL13 IL10 IFNG

Biological processes related to African Tick-Bite Fever according to GeneCards Suite gene sharing:

(show all 48)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 9.97 TNF IL6 IL13 IFNG CCL3
2 positive regulation of DNA-binding transcription factor activity GO:0051091 9.85 TNF IL6 IL10
3 response to virus GO:0009615 9.85 TNF IFNG CCL5
4 platelet activation GO:0030168 9.84 VWF IL6 CD40LG
5 positive regulation of inflammatory response GO:0050729 9.82 TNF IFNG CCL3
6 regulation of insulin secretion GO:0050796 9.8 TNF IFNG CCL5
7 cellular response to organic cyclic compound GO:0071407 9.8 TNF CCL5 CCL3
8 cytokine-mediated signaling pathway GO:0019221 9.8 TNF IL6 IL13 IL10 CCL5 CCL3
9 response to glucocorticoid GO:0051384 9.79 TNF IL6 IL10
10 positive regulation of T cell proliferation GO:0042102 9.77 IL6 CD40LG CCL5
11 humoral immune response GO:0006959 9.77 TNF IL6 IFNG
12 monocyte chemotaxis GO:0002548 9.73 IL6 CCL5 CCL3
13 positive regulation of amyloid-beta formation GO:1902004 9.7 TNF IFNG
14 positive regulation of chemokine production GO:0032722 9.7 TNF IL6
15 positive regulation of glial cell proliferation GO:0060252 9.7 TNF IL6
16 leukocyte tethering or rolling GO:0050901 9.7 TNF SELE
17 protein kinase B signaling GO:0043491 9.7 TNF CCL5 CCL3
18 inflammatory response GO:0006954 9.7 TNF SELE IL6 IL13 CD40LG CCL5
19 positive regulation of macrophage activation GO:0043032 9.69 IL13 IL10
20 astrocyte activation GO:0048143 9.69 TNF IFNG
21 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.69 TNF IFNG
22 lipopolysaccharide-mediated signaling pathway GO:0031663 9.69 TNF CCL5 CCL3
23 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.68 TNF IL10
24 positive regulation of leukocyte adhesion to vascular endothelial cell GO:1904996 9.68 TNF IL6
25 macrophage chemotaxis GO:0048246 9.68 CCL5 CCL3
26 positive regulation of chemokine biosynthetic process GO:0045080 9.67 TNF IFNG
27 positive regulation of smooth muscle cell proliferation GO:0048661 9.67 TNF IL6 IL13 CCL5
28 positive regulation of neuroinflammatory response GO:0150078 9.66 TNF IL6
29 negative regulation by host of viral transcription GO:0043922 9.66 CCL5 CCL3
30 negative regulation of amyloid-beta clearance GO:1900222 9.65 TNF IFNG
31 positive regulation of MHC class II biosynthetic process GO:0045348 9.65 IL10 IFNG
32 negative regulation of lipid storage GO:0010888 9.65 TNF IL6
33 positive regulation of interleukin-1 beta biosynthetic process GO:0050725 9.64 TNF IFNG
34 endothelial cell apoptotic process GO:0072577 9.63 TNF IL10
35 positive regulation of cytokine secretion GO:0050715 9.63 TNF IL10 IFNG
36 positive regulation of natural killer cell chemotaxis GO:2000503 9.61 CCL5 CCL3
37 negative regulation of cytokine production involved in immune response GO:0002719 9.61 TNF IL10
38 leukocyte cell-cell adhesion GO:0007159 9.61 SELE CD40LG CCL5
39 regulation of immunoglobulin secretion GO:0051023 9.58 TNF CD40LG
40 negative regulation of cytokine secretion involved in immune response GO:0002740 9.58 TNF IL10
41 microglial cell activation GO:0001774 9.58 TNF IL13 IFNG
42 positive regulation of JAK-STAT cascade GO:0046427 9.56 TNF IL6 IL10 CCL5
43 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.55 TNF IFNG
44 receptor biosynthetic process GO:0032800 9.54 TNF IL10
45 positive regulation of vitamin D biosynthetic process GO:0060557 9.49 TNF IFNG
46 positive regulation of nitrogen compound metabolic process GO:0051173 9.48 TNF IFNG
47 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.35 TNF IL6 IL13 IFNG CCL5
48 immune response GO:0006955 9.23 TNF IL6 IL13 IL10 IFNG CD40LG

Molecular functions related to African Tick-Bite Fever according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 CCR5 chemokine receptor binding GO:0031730 9.26 CCL5 CCL3
2 cytokine activity GO:0005125 9.23 TNF IL6 IL13 IL10 IFNG CD40LG
3 phospholipase activator activity GO:0016004 9.16 CCL5 CCL3
4 CCR1 chemokine receptor binding GO:0031726 8.96 CCL5 CCL3

Sources for African Tick-Bite Fever

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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