MCID: AFR002
MIFTS: 39

African Tick-Bite Fever

Categories: Infectious diseases

Aliases & Classifications for African Tick-Bite Fever

MalaCards integrated aliases for African Tick-Bite Fever:

Name: African Tick-Bite Fever 12 15
Rickettsia Africae Spotted Fever 12
South African Tick-Bite Fever 12
African Tick Bite Fever 71

Classifications:



External Ids:

Disease Ontology 12 DOID:0050035
UMLS 71 C1320317

Summaries for African Tick-Bite Fever

Disease Ontology : 12 A spotted fever that has material basis in Rickettsia africae, which is transmitted by ticks (Amblyomma hebraeum and Amblyomma variegatum). The infection has symptom fever, has symptom eschar and has symptom maculopapular rash.

MalaCards based summary : African Tick-Bite Fever, also known as rickettsia africae spotted fever, is related to boutonneuse fever and lymphadenitis, and has symptoms including fever, maculopapular rash and eschar. An important gene associated with African Tick-Bite Fever is CD40LG (CD40 Ligand), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. Affiliated tissues include skin, heart and eye, and related phenotypes are hematopoietic system and immune system

Wikipedia : 74 African tick bite fever (ATBF) is a bacterial infection spread by the bite of a tick. Symptoms may... more...

Related Diseases for African Tick-Bite Fever

Diseases related to African Tick-Bite Fever via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 552)
# Related Disease Score Top Affiliating Genes
1 boutonneuse fever 34.1 SELE CS CD40LG
2 lymphadenitis 30.2 TNF IL10 IFNG
3 epidemic typhus 30.2 GPT CS CD40LG CCL5
4 exanthem 30.1 TNF IL6 IL10 GPT CD40LG
5 lymphopenia 30.1 IL6 IL10 IFNG
6 erysipelas 29.9 TNF IL6 CD40LG
7 cellulitis 29.6 TNF IL6 IL10 CD40LG
8 pulmonary edema 29.6 TNF IL13 IL10
9 spotted fever rickettsiosis 29.6 TNF IL10 IFNG CCL5
10 pericarditis 29.5 TNF IL6 IFNG CD40LG
11 myocarditis 29.4 TNF IL6 IL10 IFNG CD40LG
12 meningoencephalitis 29.3 TNF IL6 IL10 CD40LG CCL5
13 vasculitis 29.3 VWF TNF SELE IL6 CD40LG
14 spotted fever 29.3 VWF TNF IL10 IFNG CS CD40LG
15 stomatitis 29.1 TNF IL6 IL10 IFNG CD40LG
16 aphthous stomatitis 29.1 TNF SELE IL6 IL10 IFNG
17 cutaneous leishmaniasis 28.7 TNF IL6 IL13 IL10 IFNG
18 leishmaniasis 28.3 TNF IL6 IL13 IL10 IFNG GPT
19 lymphangitis 10.5
20 astrakhan spotted fever 10.4 CD40LG CCL5
21 epstein-barr virus hepatitis 10.4 GPT CD40LG
22 osteosclerotic myeloma 10.4 IL6 CD40LG
23 maxillary sinusitis 10.4 CD40LG CCL5
24 splenic abscess 10.4 GPT CD40LG
25 acalculous cholecystitis 10.3 GPT CD40LG
26 granulomatous hepatitis 10.3 GPT CD40LG
27 acute transverse myelitis 10.3 IL6 IL10
28 splenic sequestration 10.3 VWF CD40LG
29 autoimmune hepatitis type 1 10.3 IL10 GPT
30 obesity-hypoventilation syndrome 10.3 IL6 CCL5
31 endocrine exophthalmos 10.3 IL6 CD40LG
32 methotrexate toxicity 10.3 SELE GPT
33 mycetoma 10.3 IL10 CCL5
34 headache 10.3
35 eye lymphoma 10.3 IL6 IL10
36 anaerobic pneumonia 10.3 IL6 CCL5
37 hydrops of gallbladder 10.3 GPT CD40LG
38 chronic graft versus host disease 10.3 IL10 IFNG
39 splenic infarction 10.3 GPT CD40LG
40 viral laryngitis 10.3 GPT CD40LG
41 inflammatory bowel disease 21 10.3 IFNG GPT
42 heterophyiasis 10.3 SELE GPT CD40LG
43 bone sarcoma 10.3 IL6 IL10
44 allergic encephalomyelitis 10.3 CCL5 CCL3
45 generalized atherosclerosis 10.3 VWF IL6
46 traumatic brain injury 10.3 IL6 IL10
47 grange syndrome 10.3 VWF SELE
48 primary thrombocytopenia 10.2 VWF IL10 CD40LG
49 whiplash 10.2 CCL5 CCL3
50 critical illness polyneuropathy 10.2 SELE CS

Graphical network of the top 20 diseases related to African Tick-Bite Fever:



Diseases related to African Tick-Bite Fever

Symptoms & Phenotypes for African Tick-Bite Fever

Symptoms:

12
  • fever
  • maculopapular rash
  • eschar

MGI Mouse Phenotypes related to African Tick-Bite Fever:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.91 CCL5 CD40LG IFNG IL10 IL13 IL6
2 immune system MP:0005387 9.81 CCL5 CD40LG IFNG IL10 IL13 IL6
3 digestive/alimentary MP:0005381 9.8 IFNG IL10 IL13 IL6 TNF VWF
4 integument MP:0010771 9.5 CD40LG IFNG IL10 IL13 IL6 SELE
5 respiratory system MP:0005388 9.1 IFNG IL10 IL13 IL6 SELE TNF

Drugs & Therapeutics for African Tick-Bite Fever

Search Clinical Trials , NIH Clinical Center for African Tick-Bite Fever

Genetic Tests for African Tick-Bite Fever

Anatomical Context for African Tick-Bite Fever

MalaCards organs/tissues related to African Tick-Bite Fever:

40
Skin, Heart, Eye, Lung, Bone, Liver, Thyroid

Publications for African Tick-Bite Fever

Articles related to African Tick-Bite Fever:

(show top 50) (show all 133)
# Title Authors PMID Year
1
Seroprevalence of typhus group and spotted fever group Rickettsia exposures on Reunion island. 61
31288833 2019
2
South African Tick Bite Fever: An Overview. 61
31700846 2019
3
African Tick-Bite Fever. 61
30855745 2019
4
Rickettsioses: Cutaneous findings frequently lead to diagnosis - a review. 61
30537329 2018
5
Under-diagnosis of rickettsial disease in clinical practice: A systematic review. 61
29486240 2018
6
Diagnosis of Spotted Fever Group Rickettsioses in U.S. Travelers Returning from Africa, 2007-2016. 61
29848404 2018
7
Update on Tick-Borne Bacterial Diseases in Travelers. 61
29789953 2018
8
Rickettsioses in Denmark: A retrospective survey of clinical features and travel history. 61
29415864 2018
9
First report of African tick-bite fever in a South American traveler. 61
29796268 2018
10
A Tale of Black Eschar in a Returning Traveller. 61
28988739 2017
11
African Tick Bite Fever Treated Successfully With Rifampin in a Patient With Doxycycline Intolerance. 61
28505276 2017
12
African tick-bite fever - a tantalizing souvenir from South Africa. 61
28872753 2017
13
Fever and Multiple Eschars After an African Safari: Report of Three Cases. 61
28544092 2017
14
African tick bite fever in returning Swedish travellers. Report of two cases and aspects of diagnostics. 61
28815000 2017
15
African Tick-Bite Fever in Traveler Returning to Slovenia from Uganda. 61
27648844 2016
16
Molecular diagnosis of African tick bite fever using eschar swabs in a traveller returning from Tanzania. 61
27488618 2016
17
Evidence of Rickettsia and Orientia Infections Among Abattoir Workers in Djibouti. 61
27273647 2016
18
Phylogenetic Variants of Rickettsia africae, and Incidental Identification of "Candidatus Rickettsia Moyalensis" in Kenya. 61
27387337 2016
19
African tick bite fever. 61
27929573 2016
20
Investigation of Rickettsia, Coxiella burnetii and Bartonella in ticks from animals in South Africa. 61
26718068 2016
21
A case of African tick-bite fever in a returning traveler. 61
27516971 2016
22
African tick-bite fever in a returning traveler. 61
25795527 2015
23
A family with African tick bite fever. 61
25886872 2015
24
Images in clinical medicine: African tick-bite fever after a game-hunting expedition. 61
25738687 2015
25
First case of imported African tick-bite fever in Poland - Case report. 61
26403104 2015
26
[Exanthems and fever in travellers returning from the tropics]. 61
25231591 2014
27
High prevalence of Rickettsia africae variants in Amblyomma variegatum ticks from domestic mammals in rural western Kenya: implications for human health. 61
25325312 2014
28
Rickettsioses and Q fever in travelers (2004-2013). 61
25262433 2014
29
First molecular detection of Rickettsia africae in ticks from the Union of the Comoros. 61
25245895 2014
30
[Papulovesicular exanthem after a safari in South Africa]. 61
24419477 2014
31
[South African tick bite fever in a group of Russian tourists]. 61
25715493 2014
32
Case report of African tick-bite fever from Poland. 61
24494003 2013
33
High prevalence of spotted fever group rickettsiae in Amblyomma variegatum from Uganda and their identification using sizes of intergenic spacers. 61
24331642 2013
34
Black spots in the returning traveler. 61
24314770 2013
35
Rickettsial infections in the tropics and in the traveler. 61
23842049 2013
36
Rickettsia africae in Hyalomma dromedarii ticks from sub-Saharan Algeria. 61
23164496 2012
37
Tick-borne rickettsioses in Europe. 61
23177355 2012
38
The use of eschar swabs for the diagnosis of African tick-bite fever. 61
23141102 2012
39
Cutaneous leishmaniasis and rickettsial African tick-bite fever: a combination of exotic traveler's diseases in the same patient. 61
22788813 2012
40
[Vacation and tropical dermatoses]. 61
22532262 2012
41
[African tick bite fever--rickettsiosis after holiday in South Africa]. 61
22511280 2012
42
Molecular diagnostics of Rickettsia africae infection in travelers returning from South Africa to The Netherlands. 61
21867422 2011
43
[African Tick Bite Fever upon game hunting in South Africa]. 61
21985836 2011
44
Neurological picture. Internuclear ophthalmoplegia following African tick bite fever. 61
21421770 2011
45
Risk factors for African tick-bite fever in rural central Africa. 61
21460018 2011
46
Emergence of Rickettsia africae, Oceania. 61
21192865 2011
47
Rickettsia africae in Amblyomma variegatum and domestic ruminants on eight Caribbean islands. 61
21158615 2010
48
[Rickettsia africae infection among participants in a women's safari to South Africa]. 61
21302470 2010
49
African tick-bite fever: a new entity in the differential diagnosis of multiple eschars in travelers. Description of five cases imported from South Africa to Switzerland. 61
20233665 2010
50
[Tick bite fever in West Africa: difficulties in diagnosis of an emerging disease]. 61
20099678 2009

Variations for African Tick-Bite Fever

Expression for African Tick-Bite Fever

Search GEO for disease gene expression data for African Tick-Bite Fever.

Pathways for African Tick-Bite Fever

Pathways related to African Tick-Bite Fever according to GeneCards Suite gene sharing:

(show top 50) (show all 58)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.94 VWF TNF IL6 IL13 IL10 IFNG
2
Show member pathways
13.73 TNF IL6 IL13 IL10 CD40LG CCL5
3
Show member pathways
13.6 TNF IL6 IL13 IL10 IFNG CD40LG
4
Show member pathways
13.47 TNF IL6 IL13 IL10 IFNG CCL5
5
Show member pathways
13.34 TNF IL6 IL13 IL10 CD40LG CCL5
6
Show member pathways
13.22 TNF IL6 IL13 IL10 CD40LG CCL5
7
Show member pathways
13.22 VWF TNF IL6 IL13 IL10 IFNG
8
Show member pathways
13.07 TNF IL6 IL10 IFNG CCL5 CCL3
9
Show member pathways
12.78 TNF IL6 IL13 IL10 IFNG CD40LG
10
Show member pathways
12.58 TNF IL6 IL10 IFNG CD40LG
11
Show member pathways
12.57 TNF IL10 IFNG CD40LG
12
Show member pathways
12.57 TNF IL6 IL13 IL10 IFNG
13
Show member pathways
12.54 TNF IL6 IL10 IFNG
14 12.52 TNF IL10 IFNG CD40LG CCL5
15
Show member pathways
12.32 TNF IL6 IL13 IFNG
16
Show member pathways
12.32 TNF IL6 IFNG CCL5
17
Show member pathways
12.32 IL6 IL13 IL10 IFNG
18
Show member pathways
12.26 TNF IL6 IL10 CCL5 CCL3
19
Show member pathways
12.25 TNF IL10 IFNG CD40LG
20
Show member pathways
12.23 TNF IL6 IL13 IL10 IFNG
21 12.22 TNF IL6 IL10 IFNG
22 12.16 TNF IL6 IL13 IL10
23 12.04 TNF SELE IFNG
24
Show member pathways
12.04 TNF IL6 IL10 IFNG
25
Show member pathways
12.02 TNF IL6 IL13 IFNG
26 11.97 TNF IL6 IL10
27 11.96 TNF IL6 IFNG
28 11.96 TNF IL6 IL10 IFNG
29 11.94 TNF IL6 IL13 IL10
30 11.93 TNF SELE IL6 CCL5
31 11.91 IL6 IFNG CCL3
32 11.88 TNF SELE IL6
33 11.88 TNF IL6 IL10 IFNG
34 11.84 IL6 IL10 IFNG
35 11.84 TNF IL6 IFNG CCL5 CCL3
36 11.78 IL6 IFNG CCL3
37 11.76 SELE IL6 IL13 IFNG
38 11.75 TNF IL6 IL10
39
Show member pathways
11.75 TNF IFNG CD40LG
40 11.73 TNF IL13 IL10 IFNG CCL3
41 11.71 TNF IL6 IL10 IFNG
42 11.6 SELE IL6 IFNG
43
Show member pathways
11.6 TNF SELE IL6 IFNG CD40LG
44 11.57 TNF IL6 IL13 CCL5 CCL3
45 11.56 TNF IL6 IFNG
46 11.51 IL13 IL10 IFNG
47 11.5 TNF IL6 IFNG
48 11.36 TNF IL6 IL10
49 11.33 TNF SELE IL6 IL10 IFNG CD40LG
50 11.3 TNF IL6 IL13 IFNG

GO Terms for African Tick-Bite Fever

Cellular components related to African Tick-Bite Fever according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.61 VWF TNF IL6 IL13 IL10 IFNG
2 extracellular space GO:0005615 9.32 TNF SELE IL6 IL13 IL10 IFNG

Biological processes related to African Tick-Bite Fever according to GeneCards Suite gene sharing:

(show all 44)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 9.96 TNF IL6 IL13 IFNG CCL3
2 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.87 TNF IL6 CD40LG
3 positive regulation of DNA-binding transcription factor activity GO:0051091 9.84 TNF IL6 IL10
4 platelet activation GO:0030168 9.83 VWF IL6 CD40LG
5 response to virus GO:0009615 9.83 TNF IFNG CCL5
6 cytokine-mediated signaling pathway GO:0019221 9.8 TNF IL6 IL13 IL10 CCL5 CCL3
7 cellular response to organic cyclic compound GO:0071407 9.79 TNF CCL5 CCL3
8 regulation of insulin secretion GO:0050796 9.79 TNF IFNG CCL5
9 response to glucocorticoid GO:0051384 9.78 TNF IL6 IL10
10 positive regulation of T cell proliferation GO:0042102 9.76 IL6 CD40LG CCL5
11 humoral immune response GO:0006959 9.74 TNF IL6 IFNG
12 monocyte chemotaxis GO:0002548 9.72 IL6 CCL5 CCL3
13 positive regulation of chemokine production GO:0032722 9.69 TNF IL6
14 leukocyte tethering or rolling GO:0050901 9.69 TNF SELE
15 protein kinase B signaling GO:0043491 9.69 TNF CCL5 CCL3
16 positive regulation of glial cell proliferation GO:0060252 9.68 TNF IL6
17 positive regulation of amyloid-beta formation GO:1902004 9.68 TNF IFNG
18 astrocyte activation GO:0048143 9.68 TNF IFNG
19 positive regulation of macrophage activation GO:0043032 9.68 IL13 IL10
20 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.67 TNF IFNG
21 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.67 TNF IL10
22 macrophage chemotaxis GO:0048246 9.67 CCL5 CCL3
23 lipopolysaccharide-mediated signaling pathway GO:0031663 9.67 TNF CCL5 CCL3
24 positive regulation of smooth muscle cell proliferation GO:0048661 9.67 TNF IL6 IL13 CCL5
25 positive regulation of neuroinflammatory response GO:0150078 9.65 TNF IL6
26 negative regulation by host of viral transcription GO:0043922 9.65 CCL5 CCL3
27 positive regulation of chemokine biosynthetic process GO:0045080 9.64 TNF IFNG
28 negative regulation of amyloid-beta clearance GO:1900222 9.64 TNF IFNG
29 positive regulation of MHC class II biosynthetic process GO:0045348 9.63 IL10 IFNG
30 negative regulation of lipid storage GO:0010888 9.63 TNF IL6
31 endothelial cell apoptotic process GO:0072577 9.62 TNF IL10
32 leukocyte cell-cell adhesion GO:0007159 9.61 SELE CD40LG CCL5
33 positive regulation of natural killer cell chemotaxis GO:2000503 9.6 CCL5 CCL3
34 negative regulation of cytokine secretion involved in immune response GO:0002740 9.59 TNF IL10
35 regulation of immunoglobulin secretion GO:0051023 9.58 TNF CD40LG
36 microglial cell activation GO:0001774 9.58 TNF IL13 IFNG
37 positive regulation of JAK-STAT cascade GO:0046427 9.56 TNF IL6 IL10 CCL5
38 immune response GO:0006955 9.56 TNF IL6 IL13 IL10 IFNG CD40LG
39 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.55 TNF IL6 IL13 IFNG CCL5
40 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.54 TNF IFNG
41 receptor biosynthetic process GO:0032800 9.52 TNF IL10
42 positive regulation of vitamin D biosynthetic process GO:0060557 9.48 TNF IFNG
43 positive regulation of nitrogen compound metabolic process GO:0051173 9.46 TNF IFNG
44 inflammatory response GO:0006954 9.23 TNF SELE IL6 IL13 IL10 CD40LG

Molecular functions related to African Tick-Bite Fever according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 phospholipase activator activity GO:0016004 9.26 CCL5 CCL3
2 cytokine activity GO:0005125 9.23 TNF IL6 IL13 IL10 IFNG CD40LG
3 CCR5 chemokine receptor binding GO:0031730 9.16 CCL5 CCL3
4 CCR1 chemokine receptor binding GO:0031726 8.96 CCL5 CCL3

Sources for African Tick-Bite Fever

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
Content
Loading form....