ARHI1
MCID: AGR013
MIFTS: 12

Age-Related Hearing Impairment 1 (ARHI1)

Categories: Cardiovascular diseases

Aliases & Classifications for Age-Related Hearing Impairment 1

MalaCards integrated aliases for Age-Related Hearing Impairment 1:

Name: Age-Related Hearing Impairment 1 58 13 74
Presbycusis 1 58
Arhi1 58

Classifications:



External Ids:

OMIM 58 612448
MedGen 43 C2676230
UMLS 74 C2676230

Summaries for Age-Related Hearing Impairment 1

OMIM : 58 Age-related hearing impairment (ARHI), or presbycusis, is the progressive bilaterally symmetric deterioration of hearing ability that occurs with aging. Studies of the cochlea in many animal species and of the histopathology of human temporal bones have shown that stria vascularis volumes and spiral ganglion cell, inner hair cell, and outer hair cell populations, as well as many other cochlear cell types and structures, undergo age-related degeneration. Environmental risk factors for ARHI include noise exposure, smoking, ototoxic medication, and cardiovascular disease. Heritability estimates vary between 0.25 and 0.75 depending on, among other factors, study design (family vs twins), age range of the study population, and the phenotype studied (Huyghe et al., 2008). (612448)

MalaCards based summary : Age-Related Hearing Impairment 1, also known as presbycusis 1, is related to age-related hearing loss. An important gene associated with Age-Related Hearing Impairment 1 is ARHI1 (Age-Related Hearing Impairment 1). The drug Pharmaceutical Solutions has been mentioned in the context of this disorder. Affiliated tissues include bone.

Related Diseases for Age-Related Hearing Impairment 1

Diseases in the Age-Related Hearing Impairment 1 family:

Age-Related Hearing Impairment 2

Diseases related to Age-Related Hearing Impairment 1 via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 age-related hearing loss 11.1

Symptoms & Phenotypes for Age-Related Hearing Impairment 1

Clinical features from OMIM:

612448

Drugs & Therapeutics for Age-Related Hearing Impairment 1

Drugs for Age-Related Hearing Impairment 1 (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Pharmaceutical Solutions Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 The Baltimore HEARS Pilot Study Completed NCT02045511 Not Applicable
2 Baltimore HEARS: Hearing Equality Through Accessible Research & Solutions Recruiting NCT03442296 Not Applicable

Search NIH Clinical Center for Age-Related Hearing Impairment 1

Genetic Tests for Age-Related Hearing Impairment 1

Anatomical Context for Age-Related Hearing Impairment 1

MalaCards organs/tissues related to Age-Related Hearing Impairment 1:

42
Bone

Publications for Age-Related Hearing Impairment 1

Variations for Age-Related Hearing Impairment 1

Expression for Age-Related Hearing Impairment 1

Search GEO for disease gene expression data for Age-Related Hearing Impairment 1.

Pathways for Age-Related Hearing Impairment 1

GO Terms for Age-Related Hearing Impairment 1

Sources for Age-Related Hearing Impairment 1

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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