ARHI1
MCID: AGR013
MIFTS: 13

Age-Related Hearing Impairment 1 (ARHI1)

Categories: Cardiovascular diseases, Ear diseases

Aliases & Classifications for Age-Related Hearing Impairment 1

MalaCards integrated aliases for Age-Related Hearing Impairment 1:

Name: Age-Related Hearing Impairment 1 57 13 70
Presbycusis 1 57
Arhi1 57

Classifications:



External Ids:

OMIM® 57 612448
MedGen 41 C2676230
UMLS 70 C2676230

Summaries for Age-Related Hearing Impairment 1

OMIM® : 57 Age-related hearing impairment (ARHI), or presbycusis, is the progressive bilaterally symmetric deterioration of hearing ability that occurs with aging. Studies of the cochlea in many animal species and of the histopathology of human temporal bones have shown that stria vascularis volumes and spiral ganglion cell, inner hair cell, and outer hair cell populations, as well as many other cochlear cell types and structures, undergo age-related degeneration. Environmental risk factors for ARHI include noise exposure, smoking, ototoxic medication, and cardiovascular disease. Heritability estimates vary between 0.25 and 0.75 depending on, among other factors, study design (family vs twins), age range of the study population, and the phenotype studied (Huyghe et al., 2008). (612448) (Updated 20-May-2021)

MalaCards based summary : Age-Related Hearing Impairment 1, is also known as presbycusis 1. An important gene associated with Age-Related Hearing Impairment 1 is ARHI1 (Age-Related Hearing Impairment 1). The drug Pharmaceutical Solutions has been mentioned in the context of this disorder.

Related Diseases for Age-Related Hearing Impairment 1

Symptoms & Phenotypes for Age-Related Hearing Impairment 1

Clinical features from OMIM®:

612448 (Updated 20-May-2021)

Drugs & Therapeutics for Age-Related Hearing Impairment 1

Drugs for Age-Related Hearing Impairment 1 (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Pharmaceutical Solutions

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 The Baltimore HEARS Pilot Study: Hearing Health Care Equality Through Accessible Research & Solutions Completed NCT02045511
2 Baltimore HEARS Study: Addressing Hearing Impairment and Social Engagement Through Community-delivered Hearing Care Active, not recruiting NCT03442296

Search NIH Clinical Center for Age-Related Hearing Impairment 1

Genetic Tests for Age-Related Hearing Impairment 1

Anatomical Context for Age-Related Hearing Impairment 1

Publications for Age-Related Hearing Impairment 1

Articles related to Age-Related Hearing Impairment 1:

# Title Authors PMID Year
1
Age-related hearing loss in C57BL/6J mice is mediated by Bak-dependent mitochondrial apoptosis. 57
19901338 2009
2
Genome-wide SNP-based linkage scan identifies a locus on 8q24 for an age-related hearing impairment trait. 57
18760390 2008
3
The grainyhead like 2 gene (GRHL2), alias TFCP2L3, is associated with age-related hearing impairment. 57
17921507 2008
4
Challenges and opportunities in presbycusis. 61
21493222 2011
5
Mechanisms and genes in human strial presbycusis from animal models. 61
19285967 2009
6
Ear diseases in elderly hospital patients in Nigeria. 61
15860483 2005

Variations for Age-Related Hearing Impairment 1

Expression for Age-Related Hearing Impairment 1

Search GEO for disease gene expression data for Age-Related Hearing Impairment 1.

Pathways for Age-Related Hearing Impairment 1

GO Terms for Age-Related Hearing Impairment 1

Sources for Age-Related Hearing Impairment 1

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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