MCID: AGR019
MIFTS: 42

Age-Related Hearing Loss

Categories: Ear diseases, Neuronal diseases

Aliases & Classifications for Age-Related Hearing Loss

MalaCards integrated aliases for Age-Related Hearing Loss:

Name: Age-Related Hearing Loss 25
Presbycusis 25 71 32
Age-Related Hearing Impairment 25 17
Old-Aged Sensorineural Hearing Impairment 25
Hearing Loss, Age-Related 25
Deafness Due to Old Age 25
Presbyacusia 25

Classifications:



External Ids:

ICD10 32 H91.1
UMLS 71 C0033074

Summaries for Age-Related Hearing Loss

Genetics Home Reference : 25 Age-related hearing loss (also known as presbycusis) is a decrease in hearing ability that happens with age. In most cases, the hearing loss affects both ears. It can begin as early as a person's thirties or forties and worsens gradually over time. Age-related hearing loss first affects the ability to hear high-frequency sounds, such as speech. Affected people find it increasingly difficult to understand what others are saying, particularly when there is background noise (such as at a party). However, because the hearing loss is gradual, many people do not realize they cannot hear as well as they used to. They may turn up the television volume or start speaking louder without being aware of it. As the hearing loss worsens, it affects more frequencies of sound, making it difficult to hear more than just speech. Determining where a sound is coming from (localization) and identifying its source become more challenging. Some affected individuals also experience a ringing sensation in the ears (tinnitus) or dizziness and problems with balance (presbystasis). Age-related hearing loss often impacts a person's quality of life. Because affected individuals have trouble understanding speech, the condition affects their ability to communicate. It can contribute to social isolation, depression, and loss of self-esteem. Age-related hearing loss also causes safety issues if individuals become unable to hear smoke alarms, car horns, and other sounds that alert people to dangerous situations.

MalaCards based summary : Age-Related Hearing Loss, also known as presbycusis, is related to aging and age-related hearing impairment 2, and has symptoms including tinnitus An important gene associated with Age-Related Hearing Loss is ARHI1 (Age-Related Hearing Impairment 1), and among its related pathways/superpathways is NAD metabolism, sirtuins and aging. The drugs Risedronate and Citalopram have been mentioned in the context of this disorder. Affiliated tissues include cortex, bone and testes, and related phenotypes are behavior/neurological and homeostasis/metabolism

Related Diseases for Age-Related Hearing Loss

Diseases in the Nonsyndromic Hearing Loss family:

Age-Related Hearing Loss

Diseases related to Age-Related Hearing Loss via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 85)
# Related Disease Score Top Affiliating Genes
1 aging 29.6 SOD2 SIRT1 HIF1A
2 age-related hearing impairment 2 13.0
3 deafness, autosomal dominant 6 11.4
4 deafness, autosomal dominant 25 11.2
5 ataxia, combined cerebellar and peripheral, with hearing loss and diabetes mellitus 11.2
6 sensorineural hearing loss 10.5
7 branchiootic syndrome 1 10.5
8 hearing loss, noise-induced 10.4
9 posterior cortical atrophy 10.4 MAPT APOE
10 gerstmann syndrome 10.4 MAPT APOE
11 simultanagnosia 10.3 MAPT APOE
12 visual agnosia 10.3 MAPT APOE
13 semantic dementia 10.3 MAPT APOE
14 alzheimer disease 10 10.3 MAPT APOE
15 deafness, autosomal dominant 18 10.3 NAT2 GRHL2
16 binswanger's disease 10.3 MAPT APOE
17 nominal aphasia 10.3 MAPT APOE
18 alexia 10.3 MAPT APOE
19 deafness, autosomal dominant 28 10.3 GRM7 GRHL2
20 dementia 10.3
21 alzheimer disease 2 10.2 MAPT APOE
22 arteriolosclerosis 10.2 MAPT APOE
23 cerebral amyloid angiopathy, app-related 10.2 MAPT APOE
24 alzheimer disease mitochondrial 10.2 MAPT APOE
25 lumbosacral lipoma 10.1 SETD2 HIF1A
26 inclusion body myositis 10.1 MIR34A MAPT APOE
27 meniere disease 10.1
28 usher syndrome 10.1
29 amusia 10.1
30 acoustic neuroma 10.1
31 neuroma 10.1
32 encephalomalacia 10.1
33 sleep disorder 10.1
34 neuropathy 10.1
35 hypoxia 10.1
36 communicating hydrocephalus 10.1 MAPT APOE
37 body mass index quantitative trait locus 1 10.1
38 albinism-deafness syndrome 10.1
39 auditory system disease 10.1
40 hyperacusis 10.1
41 head injury 10.1
42 prion disease 9.9 SOD2 MAPT APOE
43 inherited metabolic disorder 9.9 SIRT1 MIR34A APOE
44 parkinson disease, late-onset 9.9
45 wolfram syndrome 1 9.9
46 deafness, autosomal dominant 5 9.9
47 adiponectin, serum level of, quantitative trait locus 1 9.9
48 drug-induced hearing loss 9.9
49 wolfram syndrome 9.9
50 lipid metabolism disorder 9.9

Comorbidity relations with Age-Related Hearing Loss via Phenotypic Disease Network (PDN):


Acute Cystitis Heart Disease
Hypertension, Essential Schizophreniform Disorder

Graphical network of the top 20 diseases related to Age-Related Hearing Loss:



Diseases related to Age-Related Hearing Loss

Symptoms & Phenotypes for Age-Related Hearing Loss

UMLS symptoms related to Age-Related Hearing Loss:


tinnitus

MGI Mouse Phenotypes related to Age-Related Hearing Loss:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.02 APOE GRHL2 GRM7 HIF1A MAPT NAT2
2 homeostasis/metabolism MP:0005376 9.9 APOE ATG9A GRM7 HIF1A MAPT NAT2
3 cardiovascular system MP:0005385 9.86 APOE GRHL2 GRM7 HIF1A MAPT SETD2
4 limbs/digits/tail MP:0005371 9.5 APOE GRHL2 GRM7 HIF1A SETD2 SIRT1
5 nervous system MP:0003631 9.28 APOE GRHL2 GRM7 HIF1A MAPT SETD2

Drugs & Therapeutics for Age-Related Hearing Loss

Drugs for Age-Related Hearing Loss (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 47)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Risedronate Approved, Investigational Phase 4 105462-24-6 5245
2
Citalopram Approved Phase 4 59729-33-8 2771
3
Norepinephrine Approved Phase 4 51-41-2 439260
4
Dopamine Approved Phase 4 51-61-6, 62-31-7 681
5 Hormones Phase 4
6 Diphosphonates Phase 4
7 Calcium, Dietary Phase 4
8 calcium channel blockers Phase 4
9 Neurotransmitter Agents Phase 4
10 Antidepressive Agents Phase 4
11 Psychotropic Drugs Phase 4
12 Serotonin Uptake Inhibitors Phase 4
13 Serotonin and Noradrenaline Reuptake Inhibitors Phase 4
14 Duloxetine Hydrochloride Phase 4
15 Analgesics Phase 4
16 Dopamine Agents Phase 4
17
Calcium Nutraceutical Phase 4 7440-70-2 271
18
Serotonin Investigational, Nutraceutical Phase 4 50-67-9 5202
19 Pharmaceutical Solutions Phase 1
20
Estradiol Approved, Investigational, Vet_approved 50-28-2 5757
21
Polyestradiol phosphate Approved 28014-46-2
22
leucovorin Approved 58-05-9 6006 143
23
Huperzine A Approved, Experimental 102518-79-6
24
Ethanol Approved 64-17-5 702
25
Triamcinolone Approved, Vet_approved 124-94-7 31307
26
Folic acid Approved, Nutraceutical, Vet_approved 59-30-3 6037
27
Pomegranate Experimental, Investigational
28 Hormone Antagonists
29 Estradiol 17 beta-cypionate
30 Estradiol 3-benzoate
31 Micronutrients
32 Trace Elements
33 Vitamins
34 Hemostatics
35 Vitamin B Complex
36 Hematinics
37 Folate
38 Nutrients
39 Vitamin B9
40 Anti-Retroviral Agents
41 Cholinergic Agents
42 Neuroprotective Agents
43 Cholinesterase Inhibitors
44 Protective Agents
45 Triamcinolone diacetate
46 triamcinolone acetonide
47 Triamcinolone hexacetonide

Interventional clinical trials:

(show all 44)
# Name Status NCT ID Phase Drugs
1 Effects of Bisphosphonates on OI-Related Hearing Loss: A Pilot Study Recruiting NCT04152551 Phase 4 Risedronate Oral Tablet
2 Sensation and Psychiatry: Linking Age-Related Hearing Loss to Late-Life Depression and Cognitive Decline Suspended NCT03321006 Phase 4 Duloxetine or escitalopram
3 A Balanced, Randomized, Placebo-Controlled, Double-Blind Study of the Efficacy and Safety of AUT00063 Versus Placebo in Age-Related Hearing Loss [CLARITY-1 Study] Completed NCT02345031 Phase 2 AUT00063;Placebo
4 A Double-Blind, Randomized, Placebo-Controlled, Single-Dose, Crossover Study Of The Safety And Efficacy Of Two Fixed Doses Of PF-04958242 In Subjects With Age-Related Sensorineural Hearing Loss Completed NCT01518920 Phase 1 PF-04958242;PF-04958242;Placebo
5 The Repeatable Battery for the Assessment of Neuropsychological Status for Hearing Impaired Individuals (RBANS-H) in Older Adults With Normal Hearing or Age-related Hearing Loss Unknown status NCT03208608
6 Tinnitus and Arterial Hypertension.is There Any Relationship? Unknown status NCT01333683
7 Evaluation of the Impact of Cochlear Implants on Cognition in Older Adults Unknown status NCT02729402
8 Use of Hearing Aids. Development and Implementation of a Counselling Program for Hearing Aid Users. Unknown status NCT02233361
9 Genetic Study of Age Related Hearing Loss Completed NCT01732289 Early Phase 1
10 Age-Related Hearing Loss: Presbycusis & Its Neural Bases Completed NCT00264407 Hormone Replacement Therapy - HRT
11 Pilot Study of the Links Between Presbyacusis and Lexical Disorders in Patients With Alzheimer's Disease or Related Disease Completed NCT03638323
12 The Baltimore HEARS Pilot Study: Hearing Health Care Equality Through Accessible Research & Solutions Completed NCT02045511
13 The Folic Acid and Carotid Intima-Media Thickness (FACIT) Study: A Randomized Controlled Trial Completed NCT00110604
14 Evaluation of Efficacy and Patient Acceptance of Sound Amplifier Téo First, in Mild and Moderate Presbycusis Patient 60 Years of Age and Older, With no Previous Hearing Aid. Completed NCT01815788
15 Clinical Trial on Cognitive, Behavioural, Quality of Life and Medico-economic Benefits of Hearing Aids in Alzheimer Disease Patients Suffering From Presbycusis Completed NCT00488007
16 Neurological Treatment to Improve the Hearing in Noise Abilities of Older Adults With Hearing Impairments. Completed NCT02147847
17 Evaluating Hearing Aid Service Delivery Models Completed NCT01788423
18 At-home Auditory Training Clinical Trial Completed NCT01950013
19 Characterizing Variability in Hearing Aid Outcomes Among Older Adults Completed NCT02448706
20 Interactive Technology for Hearing Aid Education and Acceptance Completed NCT02839759
21 Pilot Study Evaluating Surgical Optimizing of a Middle Ear Implant (MET )With Laser Velocimetry in Patients With Moderate to Severe Hearing Loss in Case of Failure of Conventional Equipment Completed NCT02845115
22 Speech-in-Noise Measures as a Predictor of Hearing Aid Outcomes Completed NCT00371449
23 PC-based Rehabilitation of Auditory Function Completed NCT00724347
24 Longitudinal Outcomes of Over-the-Counter Hearing Aids Recruiting NCT04030299
25 The Beneficial Effects of Pomegranate on Hearing of Patients Without Hemodialysis: A Prospective, Randomized, Double-blinded Clinical Trial Recruiting NCT03575390
26 Cost-effective Hearing Aid Delivery Models: Outcomes, Value, and Candidacy Recruiting NCT03579563
27 Impact of Hearing Aid Intervention on Individuals With Cognitive Disorders Recruiting NCT04049643
28 Clinical and Imaging Biomarkers of Audiovestibular Function in Infratentorial Superficial Siderosis Recruiting NCT04200664
29 Evaluation of the Hearing Aids Efficacy in Elderly Subjects: a Protocol for Multiparametric Longitudinal Study Recruiting NCT04333043
30 Mitochondrial Genetics of Presbycusis Recruiting NCT03720964
31 Neuroplasticity in Auditory Aging_Auditory Temporal processing_Project 2 Recruiting NCT03475043
32 Auditory Temporal Processes, Speech Perception and Aging Recruiting NCT03468660
33 Addressing Barriers to Adult Hearing Healthcare Recruiting NCT02928107
34 Vestibular Rehabilitation Utilizing Virtual Environments to Train Sensory Integration for Postural Control in a Functional Context Recruiting NCT04268745
35 Assessment of Age-related Hearing Loss in HIV-1 Patients Active, not recruiting NCT02154971
36 Assessment of e-Audiology for Providing Clinical Services and Support for Age-related Hearing Loss: A Pilot Study Active, not recruiting NCT04048460
37 Baltimore HEARS Study: Addressing Hearing Impairment and Social Engagement Through Community-delivered Hearing Care Active, not recruiting NCT03442296
38 Auditory Rehabilitation With Hearing Aids and Cognition in Alzheimer Patients Active, not recruiting NCT03002142
39 Effects of Huperzine A on Presbycusis-related Subjective Tinnitus and Cognitive Impairment Enrolling by invitation NCT03101722 BTHE and Huperzine A
40 Study of the Association Between Presbycusis With the Incidence of Frailty. Intake of Polyphenols for the Prevention of Presbycusis: Effects on Frailty Not yet recruiting NCT04360109
41 Objective Measurement of Hearing Aid Benefit Not yet recruiting NCT04431622
42 Enhancing Speech Intelligibility Using Transcranial Alternating Current Stimulation (tACS) Not yet recruiting NCT04036630
43 Effects of Cognitive Training on Age-Related Hearing Loss and Speech Perception Suspended NCT02294812
44 Validation of a Smartphone-Based Hearing-in-Noise Test (HearMe) Withdrawn NCT03429777

Search NIH Clinical Center for Age-Related Hearing Loss

Genetic Tests for Age-Related Hearing Loss

Anatomical Context for Age-Related Hearing Loss

MalaCards organs/tissues related to Age-Related Hearing Loss:

40
Cortex, Bone, Testes, Brain, T Cells, Kidney, Endothelial

Publications for Age-Related Hearing Loss

Articles related to Age-Related Hearing Loss:

(show top 50) (show all 1606)
# Title Authors PMID Year
1
Reduced mitophagy in the cochlea of aged C57BL/6J mice. 61
32387126 2020
2
Diagnostic and therapeutic applications of genomic medicine in progressive, late-onset, nonsyndromic sensorineural hearing loss. 61
32304785 2020
3
Progressive Dominant Hearing Loss (Autosomal Dominant Deafness-41) and P2RX2 Gene Mutations: A Phenotype-Genotype Study. 61
31593348 2020
4
Otoprotective Effects of α-lipoic Acid on A/J Mice With Age-related Hearing Loss. 61
32282782 2020
5
Does Hearing Loss in the Elderly Individuals Conform to Impairment of Specific Cognitive Domains? 61
31522629 2020
6
ALA protects against ERS-mediated apoptosis in a cochlear cell model with low citrate synthase expression. 61
32418909 2020
7
Ipsilateral Cochlear Implantation in the Presence of Observed and Irradiated Vestibular Schwannomas. 61
32551844 2020
8
IN RESPONSE TO THE LETTER TO THE EDITOR: AGE-RELATED HEARING LOSS IS STRONGLY ASSOCIATED WITH COGNITIVE DECLINE REGARDLESS OF THE APOE4 POLYMORPHISM. 61
32412726 2020
9
The Role of the General Practitioner in Managing Age-Related Hearing Loss: A Scoping Review. 61
32463699 2020
10
New age-related hearing loss candidate genes in humans: an ongoing challenge. 61
32173538 2020
11
Age-related hearing loss: Why we need to think about sex as a biological variable. 61
32557661 2020
12
White-matter integrity and hearing acuity decline in healthy subjects: Magnetic resonance tractography. 61
32216576 2020
13
Expression of aquaporins in inner ear disease. 61
31593306 2020
14
Directed functional connectivity of the hippocampus in patients with presbycusis. 61
31270776 2020
15
D-Galactose-induced oxidative stress and mitochondrial dysfunction in the cochlear basilar membrane: an in vitro aging model. 61
32026209 2020
16
Mean platelet volume and neutrophil to lymphocyte ratio in patients with tinnitus: a case-control study. 61
32571752 2020
17
Osteoporosis and hearing loss: findings from the Korea National Health and Nutrition Examination Survey 2009-2011. 61
30827872 2020
18
Age-related hearing loss influences functional connectivity of auditory cortex for the McGurk illusion. 61
32535378 2020
19
Effects of Gsta4 deficiency on age-related cochlear pathology and hearing loss in mice. 61
32044382 2020
20
Suppressed expression of LDHB promotes age-related hearing loss via aerobic glycolysis. 61
32415082 2020
21
Tinnitus, hearing loss and inflammatory processes in an older Portuguese population. 61
31829778 2020
22
Using Sox2 to alleviate the hallmarks of age-related hearing loss. 61
32173536 2020
23
Role of nutrition in the development and prevention of age-related hearing loss: A scoping review. 61
32473863 2020
24
The role of the general practitioner in managing age-related hearing loss: perspectives of general practitioners, patients and practice staff. 61
32410580 2020
25
Aging But Not Age-Related Hearing Loss Dominates the Decrease of Parvalbumin Immunoreactivity in the Primary Auditory Cortex of Mice. 61
32327469 2020
26
Cochlear Implant Performance in Adult Patients with Absent Intraoperative Electrically Evoked Compound Action Potentials. 61
32122228 2020
27
A Novel Therapy for Presbycusis. 61
32475254 2020
28
Homeostatic maintenance and age-related functional decline in the Drosophila ear. 61
32366993 2020
29
Preventing presbycusis in mice with enhanced medial olivocochlear feedback. 61
32393641 2020
30
Prevalence of presbycusis in an otologically normal population. 61
31506162 2020
31
The effect and mechanism of 19S proteasome PSMD11/Rpn6 subunit in D-Galactose induced mimetic aging models. 61
32450067 2020
32
Early Detection of High-Frequency Presbycusis Among Normal Hearing Individuals. 61
32472918 2020
33
Evidence for independent peripheral and central age-related hearing impairment. 61
32415883 2020
34
Presbycusis and Fitness to Fly. 61
32327013 2020
35
Age Differences in the Effects of Speaking Rate on Auditory, Visual, and Auditory-Visual Speech Perception. 61
31453875 2020
36
Therapist-Guided Telerehabilitation for Adult Cochlear Implant Users: Developmental and Feasibility Study. 61
32255434 2020
37
Long-Term Feeding of a High-Fat Diet Ameliorated Age-Related Phenotypes in SAMP8 Mice. 61
32423039 2020
38
Hearing-impaired population performance and the effect of hearing interventions on Montreal Cognitive Assessment (MoCA): Systematic review and meta-analysis. 61
32458435 2020
39
Age-related hearing loss and provider-patient communication across primary and secondary care settings: a cross-sectional study. 61
32253433 2020
40
c.753A>G genome editing of a Cdh23ahl allele delays age-related hearing loss and degeneration of cochlear hair cells in C57BL/6J mice. 61
32101784 2020
41
RNA-seq analysis of potential lncRNAs for age-related hearing loss in a mouse model. 61
32335544 2020
42
Association Between Hearing Loss and Postural Instability in Older Korean Adults. 61
32324231 2020
43
Genetics of Postlingual Sensorineural Hearing Loss. 61
32243624 2020
44
Mitochondrial Damage and Necroptosis in Aging Cochlea. 61
32260310 2020
45
Bilateral posterior semicircular canal dysfunction: a new finding with video head impulse test. 61
32347336 2020
46
Lovastatin protects against cisplatin-induced hearing loss in mice. 61
32062294 2020
47
Down-regulation of AMPK signaling pathway rescues hearing loss in TFB1 transgenic mice and delays age-related hearing loss. 61
32240104 2020
48
A pilot randomized controlled trial of hearing aids to improve mood and cognition in older adults. 61
32291802 2020
49
Multiparametric assessment of the impact of opsin expression and anesthesia on striatal cholinergic neurons and auditory brainstem activity. 61
31625606 2020
50
GABAA Receptors in the Mongolian Gerbil: a PET Study Using [18F]Flumazenil to Determine Receptor Binding in Young and Old Animals. 61
31102039 2020

Variations for Age-Related Hearing Loss

Expression for Age-Related Hearing Loss

Search GEO for disease gene expression data for Age-Related Hearing Loss.

Pathways for Age-Related Hearing Loss

Pathways related to Age-Related Hearing Loss according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 9.66 SIRT1 HIF1A

GO Terms for Age-Related Hearing Loss

Biological processes related to Age-Related Hearing Loss according to GeneCards Suite gene sharing:

(show all 18)
# Name GO ID Score Top Affiliating Genes
1 regulation of gene expression GO:0010468 9.76 SETD2 HIF1A GRHL2 APOE
2 negative regulation of neuron apoptotic process GO:0043524 9.72 SOD2 HIF1A APOE
3 cellular response to hypoxia GO:0071456 9.69 SIRT1 MIR34A HIF1A
4 negative regulation of gene expression GO:0010629 9.67 SIRT1 MAPT HIF1A APOE
5 triglyceride homeostasis GO:0070328 9.58 MIR34A APOE
6 cholesterol homeostasis GO:0042632 9.58 SIRT1 MIR34A APOE
7 positive regulation of macroautophagy GO:0016239 9.57 SIRT1 HIF1A
8 negative regulation of TOR signaling GO:0032007 9.56 SIRT1 HIF1A
9 positive regulation of nitric-oxide synthase activity GO:0051000 9.54 HIF1A APOE
10 positive regulation of cellular senescence GO:2000774 9.52 SIRT1 MIR34A
11 positive regulation of cholesterol efflux GO:0010875 9.49 SIRT1 APOE
12 fatty acid homeostasis GO:0055089 9.48 SIRT1 APOE
13 negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway GO:1902176 9.43 SOD2 SIRT1
14 cardiac ventricle morphogenesis GO:0003208 9.32 HIF1A GRHL2
15 axonal transport of mitochondrion GO:0019896 9.26 MAPT HIF1A
16 positive regulation of smooth muscle cell differentiation GO:0051152 9.16 SIRT1 MIR34A
17 oxygen homeostasis GO:0032364 8.96 SOD2 HIF1A
18 positive regulation of cAMP-dependent protein kinase activity GO:2000481 8.62 SPATC1L SIRT1

Molecular functions related to Age-Related Hearing Loss according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nuclear hormone receptor binding GO:0035257 8.96 SIRT1 HIF1A
2 lipoprotein particle binding GO:0071813 8.62 MAPT APOE

Sources for Age-Related Hearing Loss

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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