Aliases & Classifications for Age-Related Hearing Loss

MalaCards integrated aliases for Age-Related Hearing Loss:

Name: Age-Related Hearing Loss 26
Age-Related Hearing Impairment 26 17
Presbycusis 26 74
Old-Aged Sensorineural Hearing Impairment 26
Hearing Loss, Age-Related 26
Deafness Due to Old Age 26
Presbyacusia 26

Classifications:



External Ids:

ICD10 34 H91.1
UMLS 74 C0033074

Summaries for Age-Related Hearing Loss

Genetics Home Reference : 26 Age-related hearing loss (also known as presbycusis) is a decrease in hearing ability that happens with age. In most cases, the hearing loss affects both ears. It can begin as early as a person's thirties or forties and worsens gradually over time.

MalaCards based summary : Age-Related Hearing Loss, also known as age-related hearing impairment, is related to age-related hearing impairment 1 and age-related hearing impairment 2, and has symptoms including tinnitus An important gene associated with Age-Related Hearing Loss is ARHI2 (Age-Related Hearing Impairment 2), and among its related pathways/superpathways is Mitophagy - animal. The drugs Norepinephrine and Dopamine have been mentioned in the context of this disorder. Affiliated tissues include cortex, brain and t cells, and related phenotype is limbs/digits/tail.

Related Diseases for Age-Related Hearing Loss

Graphical network of the top 20 diseases related to Age-Related Hearing Loss:



Diseases related to Age-Related Hearing Loss

Symptoms & Phenotypes for Age-Related Hearing Loss

UMLS symptoms related to Age-Related Hearing Loss:


tinnitus

MGI Mouse Phenotypes related to Age-Related Hearing Loss:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 limbs/digits/tail MP:0005371 8.92 APOE GRM7 HIF1A SETD2

Drugs & Therapeutics for Age-Related Hearing Loss

Drugs for Age-Related Hearing Loss (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 47)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Norepinephrine Approved Phase 4 51-41-2 439260
2
Dopamine Approved Phase 4 62-31-7, 51-61-6 681
3
Citalopram Approved Phase 4 59729-33-8 2771
4 Neurotransmitter Uptake Inhibitors Phase 4
5 Neurotransmitter Agents Phase 4,Not Applicable
6 Serotonin Uptake Inhibitors Phase 4
7 Serotonin and Noradrenaline Reuptake Inhibitors Phase 4
8 Cholinergic Agents Phase 4,Not Applicable
9 Autonomic Agents Phase 4
10 Analgesics Phase 4
11 Peripheral Nervous System Agents Phase 4
12 Antiparkinson Agents Phase 4
13 Cholinergic Antagonists Phase 4
14 Duloxetine Hydrochloride Phase 4
15 Dopamine Agents Phase 4
16 Antidepressive Agents Phase 4
17 Antidepressive Agents, Second-Generation Phase 4
18 Muscarinic Antagonists Phase 4
19 Parasympatholytics Phase 4
20 Serotonin Agents Phase 4
21 Psychotropic Drugs Phase 4
22
Serotonin Investigational, Nutraceutical Phase 4 50-67-9 5202
23
carbamide peroxide Approved Phase 3 124-43-6
24 Pharmaceutical Solutions Phase 1,Not Applicable
25
Estradiol Approved, Investigational, Vet_approved 50-28-2 5757
26
Polyestradiol phosphate Approved 28014-46-2
27
leucovorin Approved Not Applicable 58-05-9 6006 143
28
Huperzine A Approved, Experimental Not Applicable 102518-79-6
29
Folic Acid Approved, Nutraceutical, Vet_approved Not Applicable 59-30-3 6037
30 Estradiol 17 beta-cypionate
31 Hormone Antagonists
32 Hormones, Hormone Substitutes, and Hormone Antagonists
33 Hormones
34 Estradiol 3-benzoate
35 Nutrients Not Applicable
36 Hemostatics Not Applicable
37 Trace Elements Not Applicable
38 Folate Not Applicable
39 Vitamin B Complex Not Applicable
40 Micronutrients Not Applicable
41 Vitamins Not Applicable
42 Vitamin B9 Not Applicable
43 Hematinics Not Applicable
44 Anti-Retroviral Agents
45 Cholinesterase Inhibitors Not Applicable
46 Neuroprotective Agents Not Applicable
47 Protective Agents Not Applicable

Interventional clinical trials:

(show all 32)
# Name Status NCT ID Phase Drugs
1 Treating Hearing Loss to Improve Mood and Cognition in Older Adults Recruiting NCT03321006 Phase 4 Duloxetine
2 Caroverin and Inner Ear Diseases Suspended NCT01174979 Phase 3 Caroverin
3 Efficacy and Safety of AUT00063 Versus Placebo in Age-Related Hearing Loss Completed NCT02345031 Phase 2 AUT00063;Placebo
4 A Study Of The Effects Of PF-04958242 In Subjects With Age-Related Hearing Loss Completed NCT01518920 Phase 1 PF-04958242;PF-04958242;Placebo
5 Use of Hearing Aids. Development and Implementation of a Counselling Program for Hearing Aid Users Unknown status NCT02233361 Not Applicable
6 Genetic Study of Age Related Hearing Loss Completed NCT01732289 Early Phase 1
7 Age-related Hearing Loss and Lexical Disorders Completed NCT03638323
8 Evaluation of Efficacy and Patient Acceptance of Sound Amplifier Téo First, in Mild and Moderate Presbycusis Patient 60 Years of Age and Older, With no Previous Hearing Aid Completed NCT01815788 Not Applicable
9 Clinical Trial on Alzheimer Disease, Presbycusis and Hearing Aids Completed NCT00488007 Not Applicable
10 Neural Changes in the Aging Auditory System Completed NCT00264407 Hormone Replacement Therapy - HRT
11 Computer-Based Auditory Rehabilitation Completed NCT02147847 Not Applicable
12 Evaluating Hearing Aid Service Delivery Models Completed NCT01788423 Not Applicable
13 At-home Auditory Training Clinical Trial Completed NCT01950013 Not Applicable
14 Variability In Hearing Aid Outcomes In Older Adults Completed NCT02448706 Not Applicable
15 Predicting Success With Hearing Aids Completed NCT00371449
16 The Effect of Folic Acid on Atherosclerosis, Cognitive Performance and Hearing Completed NCT00110604 Not Applicable
17 Validation of uHear™ as a Screening Tool to Detect Hearing Impairment in Elderly Cancer Patients Within a Comprehensive Geriatric Assessment Completed NCT02381782
18 Surgical Optimizing of a Middle Ear Implant (MET )With Laser Velocimetry in Patients With Moderate to Severe Hearing Loss in Case of Failure of Conventional Equipment Completed NCT02845115 Not Applicable
19 The Baltimore HEARS Pilot Study Completed NCT02045511 Not Applicable
20 PC-Based Rehabilitation of Auditory Function Completed NCT00724347 Not Applicable
21 The RBANS-H in Older Adults With Normal Hearing or Age-related Hearing Loss Recruiting NCT03208608
22 Assessment of Age-related Hearing Loss in HIV-1 Patients Recruiting NCT02154971
23 Cost-effective Hearing Aid Delivery Models Recruiting NCT03579563 Not Applicable
24 Baltimore HEARS: Hearing Equality Through Accessible Research & Solutions Recruiting NCT03442296 Not Applicable
25 Neuroplasticity in Auditory Aging_Project 2 Recruiting NCT03475043 Not Applicable
26 Auditory Temporal Processes in Aging Recruiting NCT03468660 Not Applicable
27 Auditory Rehabilitation and Cognition in Alzheimer Patients Recruiting NCT03002142 Not Applicable
28 Hearing Aid Education and Adaptation System Recruiting NCT02839759 Not Applicable
29 Effects of Cognitive Training on Speech Perception Active, not recruiting NCT02294812 Not Applicable
30 Effects of Hearing Rehabilitative Interventions and Huperzine A on Presbycusis(Δ,kHz, dB,MMSE, AD) Enrolling by invitation NCT03101722 Not Applicable Huperzine A
31 Evaluation of the Impact of Cochlear Implants on Cognition in Older Adults Enrolling by invitation NCT02729402 Not Applicable
32 Mitochondrial Genetics of Presbycusis Not yet recruiting NCT03720964

Search NIH Clinical Center for Age-Related Hearing Loss

Genetic Tests for Age-Related Hearing Loss

Anatomical Context for Age-Related Hearing Loss

MalaCards organs/tissues related to Age-Related Hearing Loss:

42
Cortex, Brain, T Cells, Thymus, Bone, Testes, Thyroid

Publications for Age-Related Hearing Loss

Articles related to Age-Related Hearing Loss:

(show top 50) (show all 323)
# Title Authors Year
1
The World Health Organization's hearing-impairment grading system: an evaluation for unaided communication in age-related hearing loss. ( 30318941 )
2019
2
Auditory Evoked Responses in Older Adults With Normal Hearing, Untreated, and Treated Age-Related Hearing Loss. ( 30762601 )
2019
3
The effect of age-related hearing loss and listening effort on resting state connectivity. ( 30787339 )
2019
4
Cre-Dependent Optogenetic Transgenic Mice Without Early Age-Related Hearing Loss. ( 30863301 )
2019
5
Next Generation Sequencing and Animal Models Reveal SLC9A3R1 as a New Gene Involved in Human Age-Related Hearing Loss. ( 30863428 )
2019
6
Age-Related Hearing Loss Is Accelerated by Repeated Short-Duration Loud Sound Stimulation. ( 30872984 )
2019
7
Factors associated with the efficiency of hearing aids for patients with age-related hearing loss. ( 30880929 )
2019
8
Translating animal models to human therapeutics in noise-induced and age-related hearing loss. ( 30903954 )
2019
9
Protection and Prevention of Age-Related Hearing Loss. ( 30915701 )
2019
10
Functional Change in the Caudal Pontine Reticular Nucleus Induced by Age-Related Hearing Loss. ( 29853848 )
2018
11
Audio-visual speech processing in age-related hearing loss: Stronger integration and increased frontal lobe recruitment. ( 29655940 )
2018
12
Serum uric acid and prevalence of age-related hearing loss in the Japanese population: Baseline data from the Aidai Cohort Study in Yawatahama. ( 29339204 )
2018
13
Loss of IDH2 Accelerates Age-related Hearing Loss in Male Mice. ( 29567975 )
2018
14
Age-related hearing loss: Unraveling the pieces. ( 29721536 )
2018
15
Whole-genome sequencing reveals new insights into age-related hearing loss: cumulative effects, pleiotropy and the role of selection. ( 29725052 )
2018
16
Age-Related Hearing Loss and Its Association with Depression in Later Life. ( 29752060 )
2018
17
Mutations in L-type amino acid transporter-2 support<i>SLC7A8</i>as a novel gene involved in age-related hearing loss. ( 29355479 )
2018
18
Age-Related Hearing Loss: Innovations in Hearing Augmentation. ( 29735277 )
2018
19
Sex bias in basic and preclinical age-related hearing loss research. ( 29898787 )
2018
20
Codeficiency of Lysosomal Mucolipins 3 and 1 in Cochlear Hair Cells Diminishes Outer Hair Cell Longevity and Accelerates Age-Related Hearing Loss. ( 29453205 )
2018
21
Heritability of Age-Related Hearing Loss in Middle-Aged and Elderly Chinese: A Population-Based Twin Study. ( 29794565 )
2018
22
Age-related hearing loss and communication at a PACE Day Health Center. ( 29526596 )
2018
23
Self-Stigma and Age-Related Hearing Loss: A Qualitative Study of Stigma Formation and Dimensions. ( 29379957 )
2018
24
Association of Age-Related Hearing Loss With Cognitive Function, Cognitive Impairment, and Dementia: A Systematic Review and Meta-analysis. ( 29222544 )
2018
25
How do aging and age-related hearing loss affect the ability to communicate effectively in challenging communicative conditions? ( 29941310 )
2018
26
Robust Neuronal Discrimination in Primary Auditory Cortex Despite Degradations of Spectro-temporal Acoustic Details: Comparison Between Guinea Pigs with Normal Hearing and Mild Age-Related Hearing Loss. ( 29302822 )
2018
27
The impact of age-related hearing loss and lateralized auditory attention on spatiotemporal parameters of gait during dual-tasking among community dwelling older adults. ( 30056101 )
2018
28
N-acetylcysteine Treatment Reduces Age-related Hearing Loss and Memory Impairment in the Senescence-Accelerated Prone 8 (SAMP8) Mouse Model. ( 30090654 )
2018
29
An Oral Combination of Vitamins A, C, E, and Mg++ Improves Auditory Thresholds in Age-Related Hearing Loss. ( 30108480 )
2018
30
Age-related hearing loss and cognitive decline - The potential mechanisms linking the two. ( 30177417 )
2018
31
Next-generation sequencing identified SPATC1L as a possible candidate gene for both early-onset and age-related hearing loss. ( 30177775 )
2018
32
Transient-Evoked Otoacoustic Emissions Reflect Audiometric Patterns of Age-Related Hearing Loss. ( 30198420 )
2018
33
A Tipping Point in Listening Effort: Effects of Linguistic Complexity and Age-Related Hearing Loss on Sentence Comprehension. ( 30235973 )
2018
34
Tuberous sclerosis complex-mediated mTORC1 overactivation promotes age-related hearing loss. ( 30247156 )
2018
35
Age-Related Hearing Loss. ( 30291149 )
2018
36
Association of Age-Related Hearing Loss With Multiple Adverse Health Outcomes. ( 30419115 )
2018
37
Association of Audiometric Age-Related Hearing Loss With Depressive Symptoms Among Hispanic Individuals. ( 30520955 )
2018
38
Considering Age-Related Hearing Loss in Neuropsychological Practice: Findings from a Feasibility Study. ( 30522534 )
2018
39
Rs1894720 polymorphism in MIAT increased susceptibility to age-related hearing loss by modulating the activation of miR-29b/SIRT1/PGC-1α signaling. ( 30556210 )
2018
40
Association between age‑related hearing loss and cognitive decline in C57BL/6J mice. ( 29901198 )
2018
41
Age-Related Hearing Impairment Associated NAT2, GRM7, GRHL2 Susceptibility Gene Polymorphisms and Haplotypes in Roma and Hungarian Populations. ( 29455378 )
2018
42
The Association of GRM7 Single Nucleotide Polymorphisms with Age-Related Hearing Impairment in a Taiwanese Population. ( 30100543 )
2018
43
Association of Cognition and Age-Related Hearing Impairment in the English Longitudinal Study of Ageing. ( 30193368 )
2018
44
Age-Related Hearing Loss and Communication Breakdown in the Clinical Setting. ( 28837709 )
2017
45
Otoprotective effects of ethosuximide in NOD/LtJ mice with age-related hearing loss. ( 28560432 )
2017
46
NLRP3-inflammasomes are triggered by age-related hearing loss in the inner ear of mice. ( 29312513 )
2017
47
The miR-34a/Bcl-2 Pathway Contributes to Auditory Cortex Neuron Apoptosis in Age-Related Hearing Loss. ( 28817812 )
2017
48
Resolution of Cochlear Inflammation: Novel Target for Preventing or Ameliorating Drug-, Noise- and Age-related Hearing Loss. ( 28736517 )
2017
49
Activation of miR-34a impairs autophagic flux and promotes cochlear cell death via repressing ATG9A: implications for age-related hearing loss. ( 28981097 )
2017
50
Noise-induced and age-related hearing loss: A new perspectives and potential therapies. ( 28690836 )
2017

Variations for Age-Related Hearing Loss

Expression for Age-Related Hearing Loss

Search GEO for disease gene expression data for Age-Related Hearing Loss.

Pathways for Age-Related Hearing Loss

Pathways related to Age-Related Hearing Loss according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.44 ATG9A HIF1A

GO Terms for Age-Related Hearing Loss

Biological processes related to Age-Related Hearing Loss according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of gene expression GO:0010468 9.5 APOE HIF1A SETD2
2 negative regulation of vascular smooth muscle cell proliferation GO:1904706 9.37 MIR34A SOD2
3 triglyceride homeostasis GO:0070328 9.26 APOE MIR34A
4 positive regulation of nitric-oxide synthase activity GO:0051000 9.16 APOE HIF1A
5 negative regulation of neuron apoptotic process GO:0043524 9.13 APOE HIF1A SOD2
6 oxygen homeostasis GO:0032364 8.62 HIF1A SOD2

Sources for Age-Related Hearing Loss

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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