Age-Related Hearing Loss

Categories: Ear diseases

Aliases & Classifications for Age-Related Hearing Loss

MalaCards integrated aliases for Age-Related Hearing Loss:

Name: Age-Related Hearing Loss 25
Presbycusis 25 71 32
Age-Related Hearing Impairment 25 17
Old-Aged Sensorineural Hearing Impairment 25
Hearing Loss, Age-Related 25
Deafness Due to Old Age 25
Presbyacusia 25


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ICD10 32 H91.1
UMLS 71 C0033074

Summaries for Age-Related Hearing Loss

Genetics Home Reference : 25 Age-related hearing loss (also known as presbycusis) is a decrease in hearing ability that happens with age. In most cases, the hearing loss affects both ears. It can begin as early as a person's thirties or forties and worsens gradually over time. Age-related hearing loss first affects the ability to hear high-frequency sounds, such as speech. Affected people find it increasingly difficult to understand what others are saying, particularly when there is background noise (such as at a party). However, because the hearing loss is gradual, many people do not realize they cannot hear as well as they used to. They may turn up the television volume or start speaking louder without being aware of it. As the hearing loss worsens, it affects more frequencies of sound, making it difficult to hear more than just speech. Determining where a sound is coming from (localization) and identifying its source become more challenging. Some affected individuals also experience a ringing sensation in the ears (tinnitus) or dizziness and problems with balance (presbystasis). Age-related hearing loss often impacts a person's quality of life. Because affected individuals have trouble understanding speech, the condition affects their ability to communicate. It can contribute to social isolation, depression, and loss of self-esteem. Age-related hearing loss also causes safety issues if individuals become unable to hear smoke alarms, car horns, and other sounds that alert people to dangerous situations.

MalaCards based summary : Age-Related Hearing Loss, also known as presbycusis, is related to age-related hearing impairment 2 and deafness, autosomal dominant 6, and has symptoms including tinnitus An important gene associated with Age-Related Hearing Loss is ARHI1 (Age-Related Hearing Impairment 1). The drugs Norepinephrine and Citalopram have been mentioned in the context of this disorder. Affiliated tissues include cortex, bone and testes, and related phenotypes are homeostasis/metabolism and limbs/digits/tail

Related Diseases for Age-Related Hearing Loss

Diseases related to Age-Related Hearing Loss via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 77)
# Related Disease Score Top Affiliating Genes
1 age-related hearing impairment 2 13.0
2 deafness, autosomal dominant 6 11.4
3 deafness, autosomal dominant 25 11.2
4 ataxia, combined cerebellar and peripheral, with hearing loss and diabetes mellitus 11.2
5 sensorineural hearing loss 10.5
6 branchiootic syndrome 1 10.5
7 hearing loss, noise-induced 10.4
8 dementia 10.3
9 deafness, autosomal dominant 28 10.2 GRM7 GRHL2
10 deafness, autosomal dominant 18 10.1 NAT2 GRHL2
11 cerebral artery occlusion 10.1 HIF1A APOE
12 meniere disease 10.1
13 usher syndrome 10.1
14 amusia 10.1
15 acoustic neuroma 10.1
16 neuroma 10.1
17 encephalomalacia 10.1
18 sleep disorder 10.1
19 neuropathy 10.1
20 hypoxia 10.1
21 body mass index quantitative trait locus 1 10.1
22 albinism-deafness syndrome 10.1
23 auditory system disease 10.1
24 hyperacusis 10.1
25 head injury 10.1
26 parkinson disease, late-onset 9.9
27 wolfram syndrome 1 9.9
28 body mass index quantitative trait locus 11 9.9
29 deafness, autosomal dominant 5 9.9
30 body mass index quantitative trait locus 9 9.9
31 body mass index quantitative trait locus 8 9.9
32 body mass index quantitative trait locus 4 9.9
33 body mass index quantitative trait locus 10 9.9
34 body mass index quantitative trait locus 7 9.9
35 body mass index quantitative trait locus 12 9.9
36 body mass index quantitative trait locus 14 9.9
37 adiponectin, serum level of, quantitative trait locus 1 9.9
38 body mass index quantitative trait locus 18 9.9
39 body mass index quantitative trait locus 19 9.9
40 body mass index quantitative trait locus 20 9.9
41 nonsyndromic deafness 9.9
42 drug-induced hearing loss 9.9
43 wolfram syndrome 9.9
44 lipid metabolism disorder 9.9
45 alzheimer disease 9.9
46 atherosclerosis susceptibility 9.9
47 keratitis, hereditary 9.9
48 tuberous sclerosis 1 9.9
49 proteasome-associated autoinflammatory syndrome 1 9.9
50 osteogenic sarcoma 9.9

Comorbidity relations with Age-Related Hearing Loss via Phenotypic Disease Network (PDN):

Acute Cystitis Heart Disease
Hypertension, Essential Schizophreniform Disorder

Graphical network of the top 20 diseases related to Age-Related Hearing Loss:

Diseases related to Age-Related Hearing Loss

Symptoms & Phenotypes for Age-Related Hearing Loss

UMLS symptoms related to Age-Related Hearing Loss:


MGI Mouse Phenotypes related to Age-Related Hearing Loss:

# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.61 APOE ATG9A GRM7 HIF1A NAT2 SETD2
2 limbs/digits/tail MP:0005371 9.1 APOE GRHL2 GRM7 HIF1A SETD2 SLC7A8

Drugs & Therapeutics for Age-Related Hearing Loss

Drugs for Age-Related Hearing Loss (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 53)
# Name Status Phase Clinical Trials Cas Number PubChem Id
Norepinephrine Approved Phase 4 51-41-2 439260
Citalopram Approved Phase 4 59729-33-8 2771
Dopamine Approved Phase 4 51-61-6, 62-31-7 681
Risedronate Approved, Investigational Phase 4 105462-24-6 5245
Calcium Approved, Nutraceutical Phase 4 7440-70-2 271
6 Neurotransmitter Agents Phase 4
7 Cholinergic Agents Phase 4
8 Serotonin Uptake Inhibitors Phase 4
9 Analgesics Phase 4
10 Dopamine Agents Phase 4
11 Psychotropic Drugs Phase 4
12 Antiparkinson Agents Phase 4
13 Serotonin Agents Phase 4
14 Autonomic Agents Phase 4
15 Muscarinic Antagonists Phase 4
16 Duloxetine Hydrochloride Phase 4
17 Cholinergic Antagonists Phase 4
18 Antidepressive Agents Phase 4
19 Parasympatholytics Phase 4
20 Serotonin and Noradrenaline Reuptake Inhibitors Phase 4
21 Hormones Phase 4
22 Diphosphonates Phase 4
23 Calcium, Dietary Phase 4
24 calcium channel blockers Phase 4
Serotonin Investigational, Nutraceutical Phase 4 50-67-9 5202
26 Pharmaceutical Solutions Phase 1
Polyestradiol phosphate Approved 28014-46-2
Estradiol Approved, Investigational, Vet_approved 50-28-2 5757
leucovorin Approved 58-05-9 6006 143
Ethanol Approved 64-17-5 702
Huperzine A Approved, Experimental 102518-79-6
Triamcinolone Approved, Vet_approved 124-94-7 31307
Folic acid Approved, Nutraceutical, Vet_approved 59-30-3 6037
Pomegranate Experimental, Investigational
35 Hormone Antagonists
36 Estradiol 17 beta-cypionate
37 Estradiol 3-benzoate
38 Micronutrients
39 Vitamins
40 Trace Elements
41 Hematinics
42 Vitamin B Complex
43 Vitamin B9
44 Nutrients
45 Hemostatics
46 Folate
47 Anti-Retroviral Agents
48 Neuroprotective Agents
49 Protective Agents
50 Cholinesterase Inhibitors

Interventional clinical trials:

(show all 40)
# Name Status NCT ID Phase Drugs
1 Treating Hearing Loss to Improve Mood and Cognition in Older Adults Recruiting NCT03321006 Phase 4 Duloxetine
2 Effects of Bisphosphonates on OI-Related Hearing Loss: A Pilot Study Not yet recruiting NCT04152551 Phase 4 Risedronate Oral Tablet
3 A Balanced, Randomized, Placebo-Controlled, Double-Blind Study of the Efficacy and Safety of AUT00063 Versus Placebo in Age-Related Hearing Loss [CLARITY-1 Study] Completed NCT02345031 Phase 2 AUT00063;Placebo
4 A Double-Blind, Randomized, Placebo-Controlled, Single-Dose, Crossover Study Of The Safety And Efficacy Of Two Fixed Doses Of PF-04958242 In Subjects With Age-Related Sensorineural Hearing Loss Completed NCT01518920 Phase 1 PF-04958242;PF-04958242;Placebo
5 The Repeatable Battery for the Assessment of Neuropsychological Status for Hearing Impaired Individuals (RBANS-H) in Older Adults With Normal Hearing or Age-related Hearing Loss Unknown status NCT03208608
6 Tinnitus and Arterial There Any Relationship? Unknown status NCT01333683
7 Use of Hearing Aids. Development and Implementation of a Counselling Program for Hearing Aid Users. Unknown status NCT02233361
8 Genetic Study of Age Related Hearing Loss Completed NCT01732289 Early Phase 1
9 Age-Related Hearing Loss: Presbycusis & Its Neural Bases Completed NCT00264407 Hormone Replacement Therapy - HRT
10 Pilot Study of the Links Between Presbyacusis and Lexical Disorders in Patients With Alzheimer's Disease or Related Disease Completed NCT03638323
11 The Baltimore HEARS Pilot Study: Hearing Health Care Equality Through Accessible Research & Solutions Completed NCT02045511
12 The Folic Acid and Carotid Intima-Media Thickness (FACIT) Study: A Randomized Controlled Trial Completed NCT00110604
13 Evaluation of Efficacy and Patient Acceptance of Sound Amplifier Téo First, in Mild and Moderate Presbycusis Patient 60 Years of Age and Older, With no Previous Hearing Aid. Completed NCT01815788
14 Clinical Trial on Cognitive, Behavioural, Quality of Life and Medico-economic Benefits of Hearing Aids in Alzheimer Disease Patients Suffering From Presbycusis Completed NCT00488007
15 Neurological Treatment to Improve the Hearing in Noise Abilities of Older Adults With Hearing Impairments. Completed NCT02147847
16 Evaluating Hearing Aid Service Delivery Models Completed NCT01788423
17 At-home Auditory Training Clinical Trial Completed NCT01950013
18 Characterizing Variability in Hearing Aid Outcomes Among Older Adults Completed NCT02448706
19 Pilot Study Evaluating Surgical Optimizing of a Middle Ear Implant (MET )With Laser Velocimetry in Patients With Moderate to Severe Hearing Loss in Case of Failure of Conventional Equipment Completed NCT02845115
20 Speech-in-Noise Measures as a Predictor of Hearing Aid Outcomes Completed NCT00371449
21 PC-based Rehabilitation of Auditory Function Completed NCT00724347
22 Assessment of Age-related Hearing Loss in HIV-1 Patients Recruiting NCT02154971
23 Longitudinal Outcomes of Over-the-Counter Hearing Aids Recruiting NCT04030299
24 The Beneficial Effects of Pomegranate on Hearing of Patients Without Hemodialysis: A Prospective, Randomized, Double-blinded Clinical Trial Recruiting NCT03575390
25 Cost-effective Hearing Aid Delivery Models: Outcomes, Value, and Candidacy Recruiting NCT03579563
26 Mitochondrial Genetics of Presbycusis Recruiting NCT03720964
27 Auditory Temporal Processes, Speech Perception and Aging Recruiting NCT03468660
28 Addressing Barriers to Adult Hearing Healthcare Recruiting NCT02928107
29 Neuroplasticity in Auditory Aging_Auditory Temporal processing_Project 2 Recruiting NCT03475043
30 Interactive Technology for Hearing Aid Education and Acceptance Recruiting NCT02839759
31 Assessment of e-Audiology for Providing Clinical Services and Support for Age-related Hearing Loss: A Pilot Study Active, not recruiting NCT04048460
32 Baltimore HEARS Study: Addressing Hearing Impairment and Social Engagement Through Community-delivered Hearing Care Active, not recruiting NCT03442296
33 Auditory Rehabilitation With Hearing Aids and Cognition in Alzheimer Patients Active, not recruiting NCT03002142
34 Effects of Huperzine A on Presbycusis-related Subjective Tinnitus and Cognitive Impairment Enrolling by invitation NCT03101722 BTHE and Huperzine A
35 Evaluation of the Impact of Cochlear Implants on Cognition in Older Adults Enrolling by invitation NCT02729402
36 Impact of Hearing Aid Intervention on Individuals With Cognitive Disorders Not yet recruiting NCT04049643
37 Clinical and Imaging Biomarkers of Audiovestibular Function in Infratentorial Superficial Siderosis Not yet recruiting NCT04200664
38 Validation of a Smartphone-Based Hearing-in-Noise Test (HearMe) Not yet recruiting NCT03429777
39 Enhancing Speech Intelligibility Using Transcranial Alternating Current Stimulation (tACS) Not yet recruiting NCT04036630
40 Effects of Cognitive Training on Age-Related Hearing Loss and Speech Perception Suspended NCT02294812

Search NIH Clinical Center for Age-Related Hearing Loss

Genetic Tests for Age-Related Hearing Loss

Anatomical Context for Age-Related Hearing Loss

MalaCards organs/tissues related to Age-Related Hearing Loss:

Cortex, Bone, Testes, Brain, T Cells, Kidney, Endothelial

Publications for Age-Related Hearing Loss

Articles related to Age-Related Hearing Loss:

(show top 50) (show all 1545)
# Title Authors PMID Year
Multiparametric assessment of the impact of opsin expression and anesthesia on striatal cholinergic neurons and auditory brainstem activity. 61
31625606 2020
Functional analysis of candidate genes from genome-wide association studies of hearing. 61
31927188 2020
D-Galactose-induced oxidative stress and mitochondrial dysfunction in the cochlear basilar membrane: an in vitro aging model. 61
32026209 2020
Age-related insult of cochlear ribbon synapses: An early-onset contributor to D-galactose-induced aging in mice. 61
31870891 2020
Assessing fractional hair cell survival in archival human temporal bones. 61
30963586 2020
Intraoperative Erb's Point-Vertex recording increases brainstem auditory evoked potential wave V amplitude. 61
31881448 2020
Redox activation of excitatory pathways in auditory neurons as mechanism of age-related hearing loss. 61
32000019 2020
Altered verbal fluency processes in older adults with age-related hearing loss. 61
31790801 2020
Deficiency of the ER-stress-regulator MANF triggers progressive outer hair cell death and hearing loss. 61
32029702 2020
Effect of SOD2 methylation on mitochondrial DNA4834-bp deletion mutation in marginal cells under oxidative stress. 61
31465718 2020
Understanding hormone and hormone therapies' impact on the auditory system. 61
32026519 2020
Metformin attenuates the D‑galactose‑induced aging process via the UPR through the AMPK/ERK1/2 signaling pathways. 61
31922237 2020
The Revised Hearing Handicap Inventory and Screening Tool Based on Psychometric Reevaluation of the Hearing Handicap Inventories for the Elderly and Adults. 61
31124792 2020
Age-related changes in the number of cresyl-violet-stained, parvalbumin and NMDAR 2B expressing neurons in the human spiral ganglion. 61
31981822 2020
Histology of the Cochlear Outer Sulcus Cells in Normal Human Ears, Presbycusis, and Menière's Disease. 61
31899710 2020
Presbycusis: An Update on Cochlear Mechanisms and Therapies. 61
31947524 2020
Age-Dependent Changes in the Cochlea. 61
31117093 2020
Generation of a ChATCre mouse line without the early onset hearing loss typical of the C57BL/6J strain. 61
31982642 2020
Hearing loss through apoptosis of the spiral ganglion neurons in apolipoprotein E knockout mice fed with a western diet. 61
31948760 2020
Reliability and Validity of Self-Screening Tool for Hearing Loss in Older Adults. 61
32021135 2020
Short-term NAD+ supplementation prevents hearing loss in mouse models of Cockayne syndrome. 61
31934345 2020
Quantitative criteria for age-related hearing loss using audiometric configuration analysis. 61
31628535 2020
Repeated Moderate Sound Exposure Causes Accumulated Trauma to Cochlear Ribbon Synapses in Mice. 61
31935490 2020
Genetics of age-related hearing loss. 61
31989664 2020
Neural Signatures of Working Memory in Age-related Hearing Loss. 61
31935488 2020
Hearing loss is an early biomarker in APP/PS1 Alzheimer's disease mice. 61
31870800 2020
Temporal Coding of Single Auditory Nerve Fibers Is Not Degraded in Aging Gerbils. 61
31719164 2020
Degradation and modification of cochlear gap junction proteins in the early development of age-related hearing loss. 61
31988333 2020
Comparison of Cortical Auditory Evoked Potential Findings in Presbycusis with Low and High Word Recognition Score. 61
31935193 2019
Comparison of Cortical Auditory Evoked Potential Findings in Presbycusis with Low and High Word Recognition Score. 61
31914374 2019
Association Between Microvascular Retinal Signs and Age-Related Hearing Loss in the Atherosclerosis Risk in Communities Neurocognitive Study (ARIC-NCS). 61
31876936 2019
Association between hearing loss and hereditary ATTR amyloidosis. 61
31502881 2019
Tinnitus, hearing loss and inflammatory processes in an older Portuguese population. 61
31829778 2019
Age-related hearing loss and tinnitus, dementia risk, and auditory amplification outcomes. 61
31557539 2019
Age-related Hearing Loss Is Strongly Associated With Cognitive Decline Regardless of the APOE4 Polymorphism. 61
31664002 2019
Age-related hearing loss associated with altered response efficiency and variability on a visual sustained attention task. 61
31868123 2019
Auditory-frontal Channeling in α and β Bands is Altered by Age-related Hearing Loss and Relates to Speech Perception in Noise. 61
31705894 2019
The local translation of KNa in dendritic projections of auditory neurons and the roles of KNa in the transition from hidden to overt hearing loss. 61
31812952 2019
A Retrospective Cohort Study of Longitudinal Audiologic Assessment in Single and Fractionated Stereotactic Radiosurgery for Vestibular Schwannoma. 61
31215628 2019
Simulation-based learning to enhance students' knowledge and skills in educating older patients. 61
31812785 2019
Mouse methods and models for studies in hearing. 61
31795658 2019
Extended high-frequency hearing enhances speech perception in noise. 61
31685611 2019
Age-related hearing loss increases full-brain connectivity while reversing directed signaling within the dorsal-ventral pathway for speech. 61
31346715 2019
Effects of enriched endogenous omega-3 fatty acids on age-related hearing loss in mice. 61
31771637 2019
Association of Subclinical Hearing Loss With Cognitive Performance. 61
31725853 2019
Ultrastructural defects in stereocilia and tectorial membrane in aging mouse and human cochleae. 61
31762086 2019
[Changes of BK(Ca) on vascular striaepericytes of D-galactose-induced aging model in guinea pigs]. 61
31795546 2019
Protective Effects of Silymarin Against Age-Related Hearing Loss in an Aging Rat Model. 61
31750160 2019
Augmentation of cellular NAD+ by NQO1 enzymatic action improves age-related hearing impairment. 61
31353811 2019
"Passenger gene" problem in transgenic C57BL/6 mice used in hearing research. 61
31622631 2019

Variations for Age-Related Hearing Loss

Expression for Age-Related Hearing Loss

Search GEO for disease gene expression data for Age-Related Hearing Loss.

Pathways for Age-Related Hearing Loss

GO Terms for Age-Related Hearing Loss

Biological processes related to Age-Related Hearing Loss according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of vascular smooth muscle cell proliferation GO:1904706 9.46 SOD2 MIR34A
2 embryonic organ development GO:0048568 9.43 SETD2 GRHL2
3 negative regulation of neuron apoptotic process GO:0043524 9.43 SOD2 HIF1A APOE
4 embryonic cranial skeleton morphogenesis GO:0048701 9.4 SETD2 GRHL2
5 triglyceride homeostasis GO:0070328 9.37 MIR34A APOE
6 positive regulation of nitric-oxide synthase activity GO:0051000 9.32 HIF1A APOE
7 cardiac ventricle morphogenesis GO:0003208 9.16 HIF1A GRHL2
8 oxygen homeostasis GO:0032364 8.96 SOD2 HIF1A
9 regulation of gene expression GO:0010468 8.92 SETD2 HIF1A GRHL2 APOE

Sources for Age-Related Hearing Loss

9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
31 HPO
32 ICD10
33 ICD10 via Orphanet
37 LifeMap
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
54 Novoseek
57 OMIM via Orphanet
61 PubMed
70 Tocris
72 UMLS via Orphanet
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