Aliases & Classifications for Age-Related Hearing Loss

MalaCards integrated aliases for Age-Related Hearing Loss:

Name: Age-Related Hearing Loss 25
Presbycusis 25 73
Old-Aged Sensorineural Hearing Impairment 25
Age-Related Hearing Impairment 25
Hearing Loss, Age-Related 25
Deafness Due to Old Age 25
Presbyacusia 25

Classifications:



External Ids:

ICD10 33 H91.1
UMLS 73 C0033074

Summaries for Age-Related Hearing Loss

Genetics Home Reference : 25 Age-related hearing loss (also known as presbycusis) is a decrease in hearing ability that happens with age. In most cases, the hearing loss affects both ears. It can begin as early as a person's thirties or forties and worsens gradually over time.

MalaCards based summary : Age-Related Hearing Loss, also known as presbycusis, is related to age-related hearing impairment 1 and age-related hearing impairment 2, and has symptoms including tinnitus An important gene associated with Age-Related Hearing Loss is ARHI1 (Age-Related Hearing Impairment 1), and among its related pathways/superpathways is Mitophagy - animal. The drugs Dopamine and Norepinephrine have been mentioned in the context of this disorder. Affiliated tissues include cortex and brain.

Related Diseases for Age-Related Hearing Loss

Diseases related to Age-Related Hearing Loss via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 12)
# Related Disease Score Top Affiliating Genes
1 age-related hearing impairment 1 12.6
2 age-related hearing impairment 2 12.6
3 aging 10.6
4 ataxia, combined cerebellar and peripheral, with hearing loss and diabetes mellitus 10.6
5 retinal ischemia 10.1 HIF1A SETD2
6 neuronitis 9.9
7 depression 9.9
8 anxiety 9.8
9 dementia 9.8
10 hyperacusis 9.8
11 inclusion body myositis 9.6 APOE MIR34A
12 parkinson disease, late-onset 9.4 APOE NAT2 SOD2

Comorbidity relations with Age-Related Hearing Loss via Phenotypic Disease Network (PDN):


Acute Cystitis Heart Disease
Hypertension, Essential Schizophreniform Disorder

Graphical network of the top 20 diseases related to Age-Related Hearing Loss:



Diseases related to Age-Related Hearing Loss

Symptoms & Phenotypes for Age-Related Hearing Loss

UMLS symptoms related to Age-Related Hearing Loss:


tinnitus

Drugs & Therapeutics for Age-Related Hearing Loss

Drugs for Age-Related Hearing Loss (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 45)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dopamine Approved Phase 4 51-61-6, 62-31-7 681
2
Norepinephrine Approved Phase 4 51-41-2 439260
3
Citalopram Approved Phase 4 59729-33-8 2771
4 Analgesics Phase 4
5 Cholinergic Agents Phase 4,Not Applicable
6 Muscarinic Antagonists Phase 4
7 Cholinergic Antagonists Phase 4
8 Serotonin Agents Phase 4
9 Serotonin and Noradrenaline Reuptake Inhibitors Phase 4
10 Serotonin Uptake Inhibitors Phase 4
11 Neurotransmitter Agents Phase 4,Not Applicable
12 Neurotransmitter Uptake Inhibitors Phase 4
13 Parasympatholytics Phase 4
14 Dopamine Agents Phase 4
15 Duloxetine Hydrochloride Phase 4
16 Peripheral Nervous System Agents Phase 4
17 Antidepressive Agents Phase 4
18 Antidepressive Agents, Second-Generation Phase 4
19 Antiparkinson Agents Phase 4
20 Psychotropic Drugs Phase 4
21 Autonomic Agents Phase 4
22
Serotonin Investigational, Nutraceutical Phase 4 50-67-9 5202
23 Pharmaceutical Solutions Phase 1,Not Applicable
24 Estradiol valerate Approved, Investigational, Vet_approved 979-32-8
25
Estradiol Approved, Investigational, Vet_approved 50-28-2 5757
26
Polyestradiol phosphate Approved 28014-46-2
27
Huperzine A Approved, Investigational Not Applicable 102518-79-6
28
leucovorin Approved, Nutraceutical Not Applicable 58-05-9 143 6006
29
Folic Acid Approved, Nutraceutical, Vet_approved Not Applicable 59-30-3 6037
30 Micronutrients Not Applicable
31 Hematinics Not Applicable
32 Hemostatics Not Applicable
33 Hormone Antagonists
34 Trace Elements Not Applicable
35 Hormones
36 Hormones, Hormone Substitutes, and Hormone Antagonists
37 Vitamin B Complex Not Applicable
38 Estradiol 17 beta-cypionate
39 Estradiol 3-benzoate
40 Vitamins Not Applicable
41 Cholinesterase Inhibitors Not Applicable
42 Neuroprotective Agents Not Applicable
43 Protective Agents Not Applicable
44 Folate Nutraceutical Not Applicable
45 Vitamin B9 Nutraceutical Not Applicable

Interventional clinical trials:

(show all 30)
# Name Status NCT ID Phase Drugs
1 Treating Hearing Loss to Improve Mood and Cognition in Older Adults Recruiting NCT03321006 Phase 4 Duloxetine
2 Caroverin and Inner Ear Diseases Suspended NCT01174979 Phase 3 Caroverin
3 Efficacy and Safety of AUT00063 Versus Placebo in Age-Related Hearing Loss Completed NCT02345031 Phase 2 AUT00063;Placebo
4 A Study Of The Effects Of PF-04958242 In Subjects With Age-Related Hearing Loss Completed NCT01518920 Phase 1 PF-04958242;PF-04958242;Placebo
5 Use of Hearing Aids. Development and Implementation of a Counselling Program for Hearing Aid Users Unknown status NCT02233361 Not Applicable
6 Genetic Study of Age Related Hearing Loss Completed NCT01732289 Early Phase 1
7 Evaluation of Efficacy and Patient Acceptance of Sound Amplifier Téo First, in Mild and Moderate Presbycusis Patient 60 Years of Age and Older, With no Previous Hearing Aid Completed NCT01815788 Not Applicable
8 Clinical Trial on Alzheimer Disease, Presbycusis and Hearing Aids Completed NCT00488007 Not Applicable
9 Neural Changes in the Aging Auditory System Completed NCT00264407 Hormone Replacement Therapy - HRT
10 Computer-Based Auditory Rehabilitation Completed NCT02147847 Not Applicable
11 At-home Auditory Training Clinical Trial Completed NCT01950013 Not Applicable
12 Variability In Hearing Aid Outcomes In Older Adults Completed NCT02448706 Not Applicable
13 Predicting Success With Hearing Aids Completed NCT00371449
14 The Effect of Folic Acid on Atherosclerosis, Cognitive Performance and Hearing Completed NCT00110604 Not Applicable
15 Validation of uHear™ as a Screening Tool to Detect Hearing Impairment in Elderly Cancer Patients Within a Comprehensive Geriatric Assessment Completed NCT02381782
16 Surgical Optimizing of a Middle Ear Implant (MET )With Laser Velocimetry in Patients With Moderate to Severe Hearing Loss in Case of Failure of Conventional Equipment Completed NCT02845115 Not Applicable
17 The Baltimore HEARS Pilot Study Completed NCT02045511 Not Applicable
18 PC-Based Rehabilitation of Auditory Function Completed NCT00724347 Not Applicable
19 The RBANS-H in Older Adults With Normal Hearing or Age-related Hearing Loss Recruiting NCT03208608
20 Assessment of Age-related Hearing Loss in HIV-1 Patients Recruiting NCT02154971
21 Effects of Hearing Rehabilitative Interventions and Huperzine A on Presbycusis(Δ,kHz, dB,MMSE, AD) Recruiting NCT03101722 Not Applicable Huperzine A
22 Neuroplasticity in Auditory Aging_Project 2 Recruiting NCT03475043 Not Applicable
23 Auditory Temporal Processes in Aging Recruiting NCT03468660 Not Applicable
24 Auditory Rehabilitation and Cognition in Alzheimer Patients Recruiting NCT03002142 Not Applicable
25 Effects of Cognitive Training on Speech Perception Active, not recruiting NCT02294812 Not Applicable
26 Evaluating Hearing Aid Service Delivery Models Active, not recruiting NCT01788423 Not Applicable
27 Evaluation of the Impact of Cochlear Implants on Cognition in Older Adults Enrolling by invitation NCT02729402 Not Applicable
28 Cost-effective Hearing Aid Delivery Models Not yet recruiting NCT03579563 Not Applicable
29 Baltimore HEARS: Hearing Equality Through Accessible Research & Solutions Not yet recruiting NCT03442296 Not Applicable
30 Hearing Aid Education and Adaptation System Not yet recruiting NCT02839759 Not Applicable

Search NIH Clinical Center for Age-Related Hearing Loss

Genetic Tests for Age-Related Hearing Loss

Anatomical Context for Age-Related Hearing Loss

MalaCards organs/tissues related to Age-Related Hearing Loss:

41
Cortex, Brain

Publications for Age-Related Hearing Loss

Articles related to Age-Related Hearing Loss:

(show top 50) (show all 63)
# Title Authors Year
1
Functional Change in the Caudal Pontine Reticular Nucleus Induced by Age-Related Hearing Loss. ( 29853848 )
2018
2
Audio-visual speech processing in age-related hearing loss: Stronger integration and increased frontal lobe recruitment. ( 29655940 )
2018
3
Serum uric acid and prevalence of age-related hearing loss in the Japanese population: Baseline data from the Aidai Cohort Study in Yawatahama. ( 29339204 )
2018
4
Loss of IDH2 Accelerates Age-related Hearing Loss in Male Mice. ( 29567975 )
2018
5
Age-related hearing loss: Unraveling the pieces. ( 29721536 )
2018
6
Whole-genome sequencing reveals new insights into age-related hearing loss: cumulative effects, pleiotropy and the role of selection. ( 29725052 )
2018
7
Age-Related Hearing Loss and Its Association with Depression in Later Life. ( 29752060 )
2018
8
Mutations in L-type amino acid transporter-2 support<i>SLC7A8</i>as a novel gene involved in age-related hearing loss. ( 29355479 )
2018
9
Age-Related Hearing Loss: Innovations in Hearing Augmentation. ( 29735277 )
2018
10
Sex bias in basic and preclinical age-related hearing loss research. ( 29898787 )
2018
11
Codeficiency of Lysosomal Mucolipins 3 and 1 in Cochlear Hair Cells Diminishes Outer Hair Cell Longevity and Accelerates Age-Related Hearing Loss. ( 29453205 )
2018
12
Heritability of Age-Related Hearing Loss in Middle-Aged and Elderly Chinese: A Population-Based Twin Study. ( 29794565 )
2018
13
Age-related hearing loss and communication at a PACE Day Health Center. ( 29526596 )
2018
14
Self-Stigma and Age-Related Hearing Loss: A Qualitative Study of Stigma Formation and Dimensions. ( 29379957 )
2018
15
Association of Age-Related Hearing Loss With Cognitive Function, Cognitive Impairment, and Dementia: A Systematic Review and Meta-analysis. ( 29222544 )
2018
16
How do aging and age-related hearing loss affect the ability to communicate effectively in challenging communicative conditions? ( 29941310 )
2018
17
Robust Neuronal Discrimination in Primary Auditory Cortex Despite Degradations of Spectro-temporal Acoustic Details: Comparison Between Guinea Pigs with Normal Hearing and Mild Age-Related Hearing Loss. ( 29302822 )
2018
18
Age-Related Hearing Loss and Communication Breakdown in the Clinical Setting. ( 28837709 )
2017
19
Otoprotective effects of ethosuximide in NOD/LtJ mice with age-related hearing loss. ( 28560432 )
2017
20
NLRP3-inflammasomes are triggered by age-related hearing loss in the inner ear of mice. ( 29312513 )
2017
21
The miR-34a/Bcl-2 Pathway Contributes to Auditory Cortex Neuron Apoptosis in Age-Related Hearing Loss. ( 28817812 )
2017
22
Resolution of Cochlear Inflammation: Novel Target for Preventing or Ameliorating Drug-, Noise- and Age-related Hearing Loss. ( 28736517 )
2017
23
Activation of miR-34a impairs autophagic flux and promotes cochlear cell death via repressing ATG9A: implications for age-related hearing loss. ( 28981097 )
2017
24
Noise-induced and age-related hearing loss: A new perspectives and potential therapies. ( 28690836 )
2017
25
Effect of age-related hearing loss on the click-rate-induced facilitation of acoustic reflex thresholds. ( 28635498 )
2017
26
A novel method of quantifying brain atrophy associated with age-related hearing loss. ( 28808617 )
2017
27
Automatic Speech Recognition Predicts Speech Intelligibility and Comprehension for Listeners With Simulated Age-Related Hearing Loss. ( 28793162 )
2017
28
Senescence-accelerated mouse prone 8 (SAMP8) as a model of age-related hearing loss. ( 28739348 )
2017
29
The Role of Insulin-Like Growth Factor 1 in the Progression of Age-Related Hearing Loss. ( 29311900 )
2017
30
The impact of hearing aids and age-related hearing loss on auditory plasticity across three months - An electrical neuroimaging study. ( 28705608 )
2017
31
Brain changes associated with age-related hearing loss. ( 28661962 )
2017
32
Sensation and Psychiatry: Linking Age-Related Hearing Loss to Late-Life Depression and Cognitive Decline. ( 29202654 )
2017
33
miR-34a/Bcl-2 signaling pathway contributes to age-related hearing loss by modulating hair cell apoptosis. ( 28756190 )
2017
34
miR-29b overexpression induces cochlear hair cell apoptosis through the regulation of SIRT1/PGC-1I+ signaling: Implications for age-related hearing loss. ( 27635430 )
2016
35
The European GWAS-identified risk SNP rs457717 within IQGAP2 is not associated with age-related hearing impairment in Han male Chinese population. ( 26187738 )
2016
36
Expression levels of the BAK1 and BCL2 genes highlight the role of apoptosis in age-related hearing impairment. ( 27555755 )
2016
37
Circulating miR-34a levels correlate with age-related hearing loss in mice and humans. ( 26802970 )
2016
38
A Large Genome-Wide Association Study of Age-Related Hearing Impairment Using Electronic Health Records. ( 27764096 )
2016
39
Contribution of adiponectin and its type 1 receptor to age-related hearing impairment. ( 25911279 )
2015
40
Genome-wide association analysis demonstrates the highly polygenic character of age-related hearing impairment. ( 24939585 )
2015
41
No association between apolipoprotein E or N-acetyltransferase 2 gene polymorphisms and age-related hearing loss. ( 25155015 )
2015
42
A Chromosome 17 Locus Engenders Frequency-Specific Non-Progressive Hearing Loss that Contributes to Age-Related Hearing Loss in Mice. ( 25940139 )
2015
43
Adiponectin deficiency exacerbates age-related hearing impairment. ( 24763046 )
2014
44
Age-Related Hearing Impairment (ARHI) associated with GJB2 single mutation IVS1+1G&amp;gt;A in the Yakut population isolate in Eastern Siberia. ( 24959830 )
2014
45
Association of GRM7 variants with different phenotype patterns of age-related hearing impairment in an elderly male Han Chinese population. ( 24146964 )
2013
46
A functional and genetic analysis of SOD2 promoter variants and their contribution to age-related hearing loss. ( 23500038 )
2013
47
Gene dose of apolipoprotein E and age-related hearing loss. ( 22542837 )
2012
48
GRM7 variants associated with age-related hearing loss based on auditory perception. ( 23102807 )
2012
49
Association of cadherin23 single nucleotide polymorphism with age-related hearing impairment in Han Chinese. ( 22581638 )
2012
50
Protective role of Nrf2 in age-related hearing loss and gentamicin ototoxicity. ( 22020098 )
2011

Variations for Age-Related Hearing Loss

Expression for Age-Related Hearing Loss

Search GEO for disease gene expression data for Age-Related Hearing Loss.

Pathways for Age-Related Hearing Loss

Pathways related to Age-Related Hearing Loss according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.44 ATG9A HIF1A

GO Terms for Age-Related Hearing Loss

Biological processes related to Age-Related Hearing Loss according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of gene expression GO:0010468 9.43 APOE HIF1A SETD2
2 positive regulation of nitric-oxide synthase activity GO:0051000 9.16 APOE HIF1A
3 negative regulation of neuron apoptotic process GO:0043524 9.13 APOE HIF1A SOD2
4 oxygen homeostasis GO:0032364 8.62 HIF1A SOD2

Sources for Age-Related Hearing Loss

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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