MCID: AGR019
MIFTS: 40

Age-Related Hearing Loss

Categories: Ear diseases

Aliases & Classifications for Age-Related Hearing Loss

MalaCards integrated aliases for Age-Related Hearing Loss:

Name: Age-Related Hearing Loss 25
Presbycusis 25 71 32
Age-Related Hearing Impairment 25 17
Old-Aged Sensorineural Hearing Impairment 25
Hearing Loss, Age-Related 25
Deafness Due to Old Age 25
Presbyacusia 25

Classifications:



External Ids:

ICD10 32 H91.1
UMLS 71 C0033074

Summaries for Age-Related Hearing Loss

Genetics Home Reference : 25 Age-related hearing loss (also known as presbycusis) is a decrease in hearing ability that happens with age. In most cases, the hearing loss affects both ears. It can begin as early as a person's thirties or forties and worsens gradually over time. Age-related hearing loss first affects the ability to hear high-frequency sounds, such as speech. Affected people find it increasingly difficult to understand what others are saying, particularly when there is background noise (such as at a party). However, because the hearing loss is gradual, many people do not realize they cannot hear as well as they used to. They may turn up the television volume or start speaking louder without being aware of it. As the hearing loss worsens, it affects more frequencies of sound, making it difficult to hear more than just speech. Determining where a sound is coming from (localization) and identifying its source become more challenging. Some affected individuals also experience a ringing sensation in the ears (tinnitus) or dizziness and problems with balance (presbystasis). Age-related hearing loss often impacts a person's quality of life. Because affected individuals have trouble understanding speech, the condition affects their ability to communicate. It can contribute to social isolation, depression, and loss of self-esteem. Age-related hearing loss also causes safety issues if individuals become unable to hear smoke alarms, car horns, and other sounds that alert people to dangerous situations.

MalaCards based summary : Age-Related Hearing Loss, also known as presbycusis, is related to age-related hearing impairment 2 and deafness, autosomal dominant 6, and has symptoms including tinnitus An important gene associated with Age-Related Hearing Loss is ARHI1 (Age-Related Hearing Impairment 1). The drugs Citalopram and Norepinephrine have been mentioned in the context of this disorder. Affiliated tissues include cortex, bone and testes, and related phenotypes are homeostasis/metabolism and limbs/digits/tail

Related Diseases for Age-Related Hearing Loss

Diseases related to Age-Related Hearing Loss via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 78)
# Related Disease Score Top Affiliating Genes
1 age-related hearing impairment 2 13.0
2 deafness, autosomal dominant 6 11.4
3 deafness, autosomal dominant 25 11.2
4 ataxia, combined cerebellar and peripheral, with hearing loss and diabetes mellitus 11.2
5 sensorineural hearing loss 10.5
6 branchiootic syndrome 1 10.4
7 hearing loss, noise-induced 10.4
8 dementia 10.3
9 deafness, autosomal dominant 28 10.2 GRM7 GRHL2
10 deafness, autosomal dominant 18 10.1 NAT2 GRHL2
11 cerebral artery occlusion 10.1 HIF1A APOE
12 meniere disease 10.1
13 usher syndrome 10.1
14 amusia 10.1
15 acoustic neuroma 10.1
16 neuroma 10.1
17 encephalomalacia 10.1
18 sleep disorder 10.1
19 neuropathy 10.1
20 hypoxia 10.1
21 body mass index quantitative trait locus 1 10.1
22 albinism-deafness syndrome 10.1
23 auditory system disease 10.1
24 hyperacusis 10.1
25 head injury 10.1
26 parkinson disease, late-onset 9.9
27 wolfram syndrome 1 9.9
28 body mass index quantitative trait locus 11 9.9
29 deafness, autosomal dominant 5 9.9
30 body mass index quantitative trait locus 9 9.9
31 body mass index quantitative trait locus 8 9.9
32 body mass index quantitative trait locus 4 9.9
33 body mass index quantitative trait locus 10 9.9
34 body mass index quantitative trait locus 7 9.9
35 body mass index quantitative trait locus 12 9.9
36 body mass index quantitative trait locus 14 9.9
37 adiponectin, serum level of, quantitative trait locus 1 9.9
38 body mass index quantitative trait locus 18 9.9
39 body mass index quantitative trait locus 19 9.9
40 body mass index quantitative trait locus 20 9.9
41 nonsyndromic deafness 9.9
42 drug-induced hearing loss 9.9
43 wolfram syndrome 9.9
44 lipid metabolism disorder 9.9
45 alzheimer disease 9.9
46 tuberous sclerosis 1 9.9
47 multinucleated neurons, anhydramnios, renal dysplasia, cerebellar hypoplasia, and hydranencephaly 9.9
48 proteasome-associated autoinflammatory syndrome 1 9.9
49 osteogenic sarcoma 9.9
50 insulin-like growth factor i 9.9

Comorbidity relations with Age-Related Hearing Loss via Phenotypic Disease Network (PDN):


Acute Cystitis Heart Disease
Hypertension, Essential Schizophreniform Disorder

Graphical network of the top 20 diseases related to Age-Related Hearing Loss:



Diseases related to Age-Related Hearing Loss

Symptoms & Phenotypes for Age-Related Hearing Loss

UMLS symptoms related to Age-Related Hearing Loss:


tinnitus

MGI Mouse Phenotypes related to Age-Related Hearing Loss:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.61 APOE ATG9A GRM7 HIF1A NAT2 SETD2
2 limbs/digits/tail MP:0005371 9.1 APOE GRHL2 GRM7 HIF1A SETD2 SLC7A8

Drugs & Therapeutics for Age-Related Hearing Loss

Drugs for Age-Related Hearing Loss (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 53)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Citalopram Approved Phase 4 59729-33-8 2771
2
Norepinephrine Approved Phase 4 51-41-2 439260
3
Dopamine Approved Phase 4 51-61-6, 62-31-7 681
4
Risedronate Approved, Investigational Phase 4 105462-24-6 5245
5
Calcium Approved, Nutraceutical Phase 4 7440-70-2 271
6 Neurotransmitter Agents Phase 4
7 Cholinergic Agents Phase 4
8 Serotonin Uptake Inhibitors Phase 4
9 Analgesics Phase 4
10 Dopamine Agents Phase 4
11 Psychotropic Drugs Phase 4
12 Muscarinic Antagonists Phase 4
13 Parasympatholytics Phase 4
14 Serotonin Agents Phase 4
15 Cholinergic Antagonists Phase 4
16 Duloxetine Hydrochloride Phase 4
17 Antidepressive Agents Phase 4
18 Autonomic Agents Phase 4
19 Serotonin and Noradrenaline Reuptake Inhibitors Phase 4
20 Antiparkinson Agents Phase 4
21 Hormones Phase 4
22 Diphosphonates Phase 4
23 Calcium, Dietary Phase 4
24 calcium channel blockers Phase 4
25
Serotonin Investigational, Nutraceutical Phase 4 50-67-9 5202
26 Pharmaceutical Solutions Phase 1
27
Polyestradiol phosphate Approved 28014-46-2
28
Estradiol Approved, Investigational, Vet_approved 50-28-2 5757
29
leucovorin Approved 58-05-9 6006 143
30
Ethanol Approved 64-17-5 702
31
Huperzine A Approved, Experimental 102518-79-6
32
Triamcinolone Approved, Vet_approved 124-94-7 31307
33
Folic acid Approved, Nutraceutical, Vet_approved 59-30-3 6037
34
Pomegranate Experimental, Investigational
35 Estradiol 17 beta-cypionate
36 Hormone Antagonists
37 Estradiol 3-benzoate
38 Trace Elements
39 Hematinics
40 Vitamin B Complex
41 Vitamins
42 Nutrients
43 Vitamin B9
44 Micronutrients
45 Hemostatics
46 Folate
47 Anti-Retroviral Agents
48 Neuroprotective Agents
49 Protective Agents
50 Cholinesterase Inhibitors

Interventional clinical trials:

(show all 40)
# Name Status NCT ID Phase Drugs
1 Treating Hearing Loss to Improve Mood and Cognition in Older Adults Recruiting NCT03321006 Phase 4 Duloxetine
2 Effects of Bisphosphonates on OI-Related Hearing Loss: A Pilot Study Not yet recruiting NCT04152551 Phase 4 Risedronate Oral Tablet
3 A Balanced, Randomized, Placebo-Controlled, Double-Blind Study of the Efficacy and Safety of AUT00063 Versus Placebo in Age-Related Hearing Loss [CLARITY-1 Study] Completed NCT02345031 Phase 2 AUT00063;Placebo
4 A Double-Blind, Randomized, Placebo-Controlled, Single-Dose, Crossover Study Of The Safety And Efficacy Of Two Fixed Doses Of PF-04958242 In Subjects With Age-Related Sensorineural Hearing Loss Completed NCT01518920 Phase 1 PF-04958242;PF-04958242;Placebo
5 The Repeatable Battery for the Assessment of Neuropsychological Status for Hearing Impaired Individuals (RBANS-H) in Older Adults With Normal Hearing or Age-related Hearing Loss Unknown status NCT03208608
6 Tinnitus and Arterial Hypertension.is There Any Relationship? Unknown status NCT01333683
7 Use of Hearing Aids. Development and Implementation of a Counselling Program for Hearing Aid Users. Unknown status NCT02233361
8 Genetic Study of Age Related Hearing Loss Completed NCT01732289 Early Phase 1
9 Age-Related Hearing Loss: Presbycusis & Its Neural Bases Completed NCT00264407 Hormone Replacement Therapy - HRT
10 Pilot Study of the Links Between Presbyacusis and Lexical Disorders in Patients With Alzheimer's Disease or Related Disease Completed NCT03638323
11 The Baltimore HEARS Pilot Study: Hearing Health Care Equality Through Accessible Research & Solutions Completed NCT02045511
12 The Folic Acid and Carotid Intima-Media Thickness (FACIT) Study: A Randomized Controlled Trial Completed NCT00110604
13 Evaluation of Efficacy and Patient Acceptance of Sound Amplifier Téo First, in Mild and Moderate Presbycusis Patient 60 Years of Age and Older, With no Previous Hearing Aid. Completed NCT01815788
14 Clinical Trial on Cognitive, Behavioural, Quality of Life and Medico-economic Benefits of Hearing Aids in Alzheimer Disease Patients Suffering From Presbycusis Completed NCT00488007
15 Neurological Treatment to Improve the Hearing in Noise Abilities of Older Adults With Hearing Impairments. Completed NCT02147847
16 Evaluating Hearing Aid Service Delivery Models Completed NCT01788423
17 At-home Auditory Training Clinical Trial Completed NCT01950013
18 Characterizing Variability in Hearing Aid Outcomes Among Older Adults Completed NCT02448706
19 Pilot Study Evaluating Surgical Optimizing of a Middle Ear Implant (MET )With Laser Velocimetry in Patients With Moderate to Severe Hearing Loss in Case of Failure of Conventional Equipment Completed NCT02845115
20 PC-based Rehabilitation of Auditory Function Completed NCT00724347
21 Speech-in-Noise Measures as a Predictor of Hearing Aid Outcomes Completed NCT00371449
22 Assessment of Age-related Hearing Loss in HIV-1 Patients Recruiting NCT02154971
23 Longitudinal Outcomes of Over-the-Counter Hearing Aids Recruiting NCT04030299
24 The Beneficial Effects of Pomegranate on Hearing of Patients Without Hemodialysis: A Prospective, Randomized, Double-blinded Clinical Trial Recruiting NCT03575390
25 Cost-effective Hearing Aid Delivery Models: Outcomes, Value, and Candidacy Recruiting NCT03579563
26 Mitochondrial Genetics of Presbycusis Recruiting NCT03720964
27 Neuroplasticity in Auditory Aging_Auditory Temporal processing_Project 2 Recruiting NCT03475043
28 Auditory Temporal Processes, Speech Perception and Aging Recruiting NCT03468660
29 Addressing Barriers to Adult Hearing Healthcare Recruiting NCT02928107
30 Interactive Technology for Hearing Aid Education and Acceptance Recruiting NCT02839759
31 Assessment of e-Audiology for Providing Clinical Services and Support for Age-related Hearing Loss: A Pilot Study Active, not recruiting NCT04048460
32 Baltimore HEARS Study: Addressing Hearing Impairment and Social Engagement Through Community-delivered Hearing Care Active, not recruiting NCT03442296
33 Auditory Rehabilitation With Hearing Aids and Cognition in Alzheimer Patients Active, not recruiting NCT03002142
34 Effects of Huperzine A on Presbycusis-related Subjective Tinnitus and Cognitive Impairment Enrolling by invitation NCT03101722 BTHE and Huperzine A
35 Evaluation of the Impact of Cochlear Implants on Cognition in Older Adults Enrolling by invitation NCT02729402
36 Impact of Hearing Aid Intervention on Individuals With Cognitive Disorders Not yet recruiting NCT04049643
37 Clinical and Imaging Biomarkers of Audiovestibular Function in Infratentorial Superficial Siderosis Not yet recruiting NCT04200664
38 Validation of a Smartphone-Based Hearing-in-Noise Test (HearMe) Not yet recruiting NCT03429777
39 Enhancing Speech Intelligibility Using Transcranial Alternating Current Stimulation (tACS) Not yet recruiting NCT04036630
40 Effects of Cognitive Training on Age-Related Hearing Loss and Speech Perception Suspended NCT02294812

Search NIH Clinical Center for Age-Related Hearing Loss

Genetic Tests for Age-Related Hearing Loss

Anatomical Context for Age-Related Hearing Loss

MalaCards organs/tissues related to Age-Related Hearing Loss:

40
Cortex, Bone, Testes, Brain, T Cells, Kidney, Endothelial

Publications for Age-Related Hearing Loss

Articles related to Age-Related Hearing Loss:

(show top 50) (show all 1514)
# Title Authors PMID Year
1
Association between hearing loss and hereditary ATTR amyloidosis. 61
31502881 2019
2
Tinnitus, hearing loss and inflammatory processes in an older Portuguese population. 61
31829778 2019
3
Age-related Hearing Loss Is Strongly Associated With Cognitive Decline Regardless of the APOE4 Polymorphism. 61
31664002 2019
4
Age-related hearing loss and tinnitus, dementia risk, and auditory amplification outcomes. 61
31557539 2019
5
The local translation of KNa in dendritic projections of auditory neurons and the roles of KNa in the transition from hidden to overt hearing loss. 61
31812952 2019
6
Auditory-frontal Channeling in α and β Bands is Altered by Age-related Hearing Loss and Relates to Speech Perception in Noise. 61
31705894 2019
7
A Retrospective Cohort Study of Longitudinal Audiologic Assessment in Single and Fractionated Stereotactic Radiosurgery for Vestibular Schwannoma. 61
31215628 2019
8
Extended high-frequency hearing enhances speech perception in noise. 61
31685611 2019
9
Age-related hearing loss increases full-brain connectivity while reversing directed signaling within the dorsal-ventral pathway for speech. 61
31346715 2019
10
Effects of enriched endogenous omega-3 fatty acids on age-related hearing loss in mice. 61
31771637 2019
11
Altered verbal fluency processes in older adults with age-related hearing loss. 61
31790801 2019
12
Association of Subclinical Hearing Loss With Cognitive Performance. 61
31725853 2019
13
Ultrastructural defects in stereocilia and tectorial membrane in aging mouse and human cochleae. 61
31762086 2019
14
[Changes of BK(Ca) on vascular striaepericytes of D-galactose-induced aging model in guinea pigs]. 61
31795546 2019
15
Protective Effects of Silymarin Against Age-Related Hearing Loss in an Aging Rat Model. 61
31750160 2019
16
Temporal coding of single auditory nerve fibers is not degraded in aging gerbils. 61
31719164 2019
17
Simulation-based learning to enhance students' knowledge and skills in educating older patients. 61
31812785 2019
18
Mouse methods and models for studies in hearing. 61
31795658 2019
19
Progressive Dominant Hearing Loss (Autosomal Dominant Deafness-41) and P2RX2 Gene Mutations: A Phenotype-Genotype Study. 61
31593348 2019
20
Meta-Analysis of Grainyhead-Like Dependent Transcriptional Networks: A Roadmap for Identifying Novel Conserved Genetic Pathways. 61
31683705 2019
21
Expression of aquaporins in inner ear disease. 61
31593306 2019
22
Quantitative criteria for age-related hearing loss using audiometric configuration analysis. 61
31628535 2019
23
Increased burden of mitochondrial DNA deletions and point mutations in early-onset age-related hearing loss in mitochondrial mutator mice. 61
31344454 2019
24
D-Stellate Neurons of the Ventral Cochlear Nucleus Decrease in Auditory Nerve-Evoked Activity during Age-Related Hearing Loss. 61
31683609 2019
25
Examining the Validity of the World Health Organization's Long-Standing Hearing Impairment Grading System for Unaided Communication in Age-Related Hearing Loss. 61
31618069 2019
26
Access to adults' hearing aids: policies and technologies used in eight countries. 61
31656335 2019
27
Hearing care across the life course provided in the community. 61
31656333 2019
28
Study of age-related changes in Middle ear transfer function. 61
31268350 2019
29
"Passenger gene" problem in transgenic C57BL/6 mice used in hearing research. 61
31622631 2019
30
Multiparametric assessment of the impact of opsin expression and anesthesia on striatal cholinergic neurons and auditory brainstem activity. 61
31625606 2019
31
Augmentation of cellular NAD+ by NQO1 enzymatic action improves age-related hearing impairment. 61
31353811 2019
32
Mice heterozygous for the Cdh23/Ahl1 mutation show age-related deficits in auditory temporal processing. 61
31247458 2019
33
Prevalence of presbycusis in an otologically normal population. 61
31506162 2019
34
Does Hearing Loss in the Elderly Individuals Conform to Impairment of Specific Cognitive Domains? 61
31522629 2019
35
The Prevalence and Clinical Characteristics of TECTA-Associated Autosomal Dominant Hearing Loss. 61
31554319 2019
36
Auditory Evoked Responses in Older Adults With Normal Hearing, Untreated, and Treated Age-Related Hearing Loss. 61
30762601 2019
37
Neuroprotective factors and incident hearing impairment in the epidemiology of hearing loss study. 61
30698838 2019
38
[Audiometric test battery for presbycusis]. 61
31549193 2019
39
Visual short-term memory binding deficit with age-related hearing loss in cognitively normal older adults. 61
31467387 2019
40
SIRT1 protects cochlear hair cell and delays age-related hearing loss via autophagy. 61
31170533 2019
41
Age-Related Hearing Loss. 61
30291149 2019
42
MicroRNAs in acquired sensorineural hearing loss. 61
31358070 2019
43
GABAergic and glutamatergic cells in the inferior colliculus dynamically express the GABAAR γ1 subunit during aging. 61
31112831 2019
44
Abnormal Tectorial Membranes in Sensorineural Hearing Loss: A Human Temporal Bone Study. 61
31219968 2019
45
Effect of SOD2 methylation on mitochondrial DNA4834-bp deletion mutation in marginal cells under oxidative stress. 61
31465718 2019
46
Retraction notice to "miR-34a/Bcl-2 signaling pathway contributes to age-related hearing loss by modulating hair cell apoptosis" [Neurosci. Lett. 661 (November) (2017) 51-56]. 61
31174918 2019
47
Down-regulation of Cav1.3 in auditory pathway promotes age-related hearing loss by enhancing calcium-mediated oxidative stress in male mice. 61
31425146 2019
48
Early functional alterations in membrane properties and neuronal degeneration are hallmarks of progressive hearing loss in NOD mice. 61
31431657 2019
49
Age‑associated variation in the expression and function of TMEM16A calcium‑activated chloride channels in the cochlear stria vascularis of guinea pigs. 61
31257512 2019
50
Hearing-impaired listeners show increased audiovisual benefit when listening to speech in noise. 61
30978494 2019

Variations for Age-Related Hearing Loss

Expression for Age-Related Hearing Loss

Search GEO for disease gene expression data for Age-Related Hearing Loss.

Pathways for Age-Related Hearing Loss

GO Terms for Age-Related Hearing Loss

Biological processes related to Age-Related Hearing Loss according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of vascular smooth muscle cell proliferation GO:1904706 9.46 SOD2 MIR34A
2 embryonic organ development GO:0048568 9.43 SETD2 GRHL2
3 negative regulation of neuron apoptotic process GO:0043524 9.43 SOD2 HIF1A APOE
4 embryonic cranial skeleton morphogenesis GO:0048701 9.4 SETD2 GRHL2
5 triglyceride homeostasis GO:0070328 9.37 MIR34A APOE
6 positive regulation of nitric-oxide synthase activity GO:0051000 9.32 HIF1A APOE
7 cardiac ventricle morphogenesis GO:0003208 9.16 HIF1A GRHL2
8 oxygen homeostasis GO:0032364 8.96 SOD2 HIF1A
9 regulation of gene expression GO:0010468 8.92 SETD2 HIF1A GRHL2 APOE

Sources for Age-Related Hearing Loss

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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