Age-Related Hearing Loss

Categories: Ear diseases, Neuronal diseases
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Aliases & Classifications for Age-Related Hearing Loss

MalaCards integrated aliases for Age-Related Hearing Loss:

Name: Age-Related Hearing Loss 42 33
Presbycusis 42 75 71 31 33
Age-Related Hearing Impairment 42 16
Presbyacusia 42 33
Old-Aged Sensorineural Hearing Impairment 42
Hearing Loss, Age-Related 42
Deafness Due to Old Age 42
Senile Deafness 33
Hard of Hearing 33


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ICD10 31 H91.1
ICD11 33 1569854675
UMLS 71 C0033074

Summaries for Age-Related Hearing Loss

MedlinePlus Genetics: 42 Age-related hearing loss (also known as presbycusis) is a decrease in hearing ability that happens with age. In most cases, the hearing loss affects both ears. It can begin as early as a person's thirties or forties and worsens gradually over time.Age-related hearing loss first affects the ability to hear high-frequency sounds, such as speech. Affected people find it increasingly difficult to understand what others are saying, particularly when there is background noise (such as at a party). However, because the hearing loss is gradual, many people do not realize they cannot hear as well as they used to. They may turn up the television volume or start speaking louder without being aware of it.As the hearing loss worsens, it affects more frequencies of sound, making it difficult to hear more than just speech. Determining where a sound is coming from (localization) and identifying its source become more challenging. Some affected individuals also experience a ringing sensation in the ears (tinnitus) or dizziness and problems with balance (presbystasis).Age-related hearing loss often impacts a person's quality of life. Because affected individuals have trouble understanding speech, the condition affects their ability to communicate. It can contribute to social isolation, depression, and loss of self-esteem. Age-related hearing loss also causes safety issues if individuals become unable to hear smoke alarms, car horns, and other sounds that alert people to dangerous situations.

MalaCards based summary: Age-Related Hearing Loss, also known as presbycusis, is related to age-related hearing impairment 2 and deafness, autosomal dominant 6, and has symptoms including tinnitus An important gene associated with Age-Related Hearing Loss is ARHI1 (Age-Related Hearing Impairment 1). The drugs Duloxetine and Dopamine have been mentioned in the context of this disorder. Affiliated tissues include cortex, kidney and brain.

Wikipedia: 75 Presbycusis (also spelled presbyacusis, from Greek πρέσβυς presbys "old" + ἄκουσις akousis "hearing"),... more...

Related Diseases for Age-Related Hearing Loss

Diseases in the Nonsyndromic Hearing Loss family:

Age-Related Hearing Loss

Diseases related to Age-Related Hearing Loss via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 168)
# Related Disease Score Top Affiliating Genes
1 age-related hearing impairment 2 11.7
2 deafness, autosomal dominant 6 11.1
3 usher syndrome, type i 11.1
4 usher syndrome, type ic 11.0
5 usher syndrome, type ih 11.0
6 usher syndrome, type ij 11.0
7 usher syndrome, type ik 11.0
8 deafness, autosomal dominant 25 10.9
9 sensorineural hearing loss 10.8
10 hearing loss, noise-induced 10.5
11 dementia 10.5
12 autism spectrum disorder 10.5
13 autism 10.4
14 congenital hemidysplasia with ichthyosiform erythroderma and limb defects 10.3
15 learning disability 10.3
16 children's interstitial lung disease 10.3
17 human immunodeficiency virus type 1 10.3
18 mild cognitive impairment 10.3
19 acquired immunodeficiency syndrome 10.3
20 disease of mental health 10.3
21 ceroid lipofuscinosis, neuronal, 5 10.3
22 aging 10.3
23 major depressive disorder 10.3
24 speech and communication disorders 10.3
25 amyloidosis 10.3
26 hypoascorbemia 10.2
27 keratomalacia 10.2
28 nutritional deficiency disease 10.2
29 attention deficit-hyperactivity disorder 10.2
30 substance abuse 10.2
31 body mass index quantitative trait locus 1 10.1
32 dysphasia, familial developmental 10.1
33 pervasive developmental disorder 10.1
34 specific language impairment 10.1
35 post-traumatic stress disorder 10.1
36 alzheimer disease, familial, 1 10.1
37 oculodentodigital dysplasia 10.1
38 insulin-like growth factor i 10.1
39 lysosomal acid lipase deficiency 10.1
40 albinism-deafness syndrome 10.1
41 abdominal obesity-metabolic syndrome 1 10.1
42 hypokalemia 10.1
43 49, xxxxy syndrome 10.1
44 hyperacusis 10.1
45 sudden sensorineural hearing loss 10.1
46 deafness, unilateral 10.0
47 neurodegeneration with brain iron accumulation 2a 10.0
48 retinitis pigmentosa 10.0
49 arts syndrome 10.0
50 fanconi anemia, complementation group e 10.0

Comorbidity relations with Age-Related Hearing Loss via Phenotypic Disease Network (PDN):

Acute Cystitis Heart Disease
Hypertension, Essential Schizophreniform Disorder

Graphical network of the top 20 diseases related to Age-Related Hearing Loss:

Diseases related to Age-Related Hearing Loss

Symptoms & Phenotypes for Age-Related Hearing Loss

UMLS symptoms related to Age-Related Hearing Loss:


Drugs & Therapeutics for Age-Related Hearing Loss

Drugs for Age-Related Hearing Loss (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 28)
# Name Status Phase Clinical Trials Cas Number PubChem Id
Duloxetine Approved Phase 4 136434-34-9, 116539-59-4 60835
Dopamine Approved Phase 4 62-31-7, 51-61-6 681
Norepinephrine Approved Phase 4 51-41-2 439260
Citalopram Approved Phase 4 59729-32-7, 59729-33-8 2771
Dexetimide Withdrawn Phase 4 21888-98-2 30843
6 Neurotransmitter Agents Phase 4
7 Dopamine Agents Phase 4
8 Psychotropic Drugs Phase 4
9 Antidepressive Agents Phase 4
10 Serotonin Uptake Inhibitors Phase 4
11 Serotonin and Noradrenaline Reuptake Inhibitors Phase 4
12 Analgesics Phase 4
Serotonin Investigational, Nutraceutical Phase 4 50-67-9 5202
Estradiol Approved, Investigational, Vet_approved 50-28-2 5757
Polyestradiol phosphate Approved 28014-46-2
Ethanol Approved 64-17-5 702
Huperzine A Approved, Experimental 102518-79-6
18 Estradiol 3-benzoate
19 Estradiol 17 beta-cypionate
20 Hormones
21 Hormone Antagonists
22 Anti-Retroviral Agents
23 Pharmaceutical Solutions
24 Astragalus
25 Neuroprotective Agents
26 Cholinesterase Inhibitors
27 Cholinergic Agents
28 Protective Agents

Interventional clinical trials:

(show all 50)
# Name Status NCT ID Phase Drugs
1 Sensation and Psychiatry: Linking Age-Related Hearing Loss to Late-Life Depression and Cognitive Decline Completed NCT03321006 Phase 4 Duloxetine or escitalopram
2 A Balanced, Randomized, Placebo-Controlled, Double-Blind Study of the Efficacy and Safety of AUT00063 Versus Placebo in Age-Related Hearing Loss [CLARITY-1 Study] Completed NCT02345031 Phase 2 AUT00063;Placebo
3 Audiology Visits After Screening for Hearing Loss: An RCT Completed NCT00105742 Phase 2
4 RCT Study of Liuwei Dihuang Pill Preventing and Treating Presbycusis With Shen (Kidney)-Yin Deficiency Recruiting NCT05125081 Phase 2 Liuwei Dihuang Pill (marketed product in China);Liuwei Dihuang Pill(placebo )
5 A Phase 1b, Prospective, Randomized, Double-Blind, Placebo-Controlled, Single-Dose, Multicenter, Safety Study of FX-322 Administered by Intratympanic Injection in Adults With Age-Related Sensorineural Hearing Loss Completed NCT04601909 Phase 1 FX-322
6 The Repeatable Battery for the Assessment of Neuropsychological Status for Hearing Impaired Individuals (RBANS-H) in Older Adults With Normal Hearing or Age-related Hearing Loss Unknown status NCT03208608
7 Use of Hearing Aids. Development and Implementation of a Counselling Program for Hearing Aid Users. Unknown status NCT02233361
8 Clinical Trial on Cognitive, Behavioural, Quality of Life and Medico-economic Benefits of Hearing Aids in Alzheimer Disease Patients Suffering From Presbycusis Completed NCT00488007
9 Age-Related Hearing Loss: Presbycusis & Its Neural Bases Completed NCT00264407 Hormone Replacement Therapy - HRT
10 Impact of Hearing Aid Technology on Self-reported Outcomes in Patients With Presbycusis - a Randomized Controlled Trial Completed NCT04539847
11 Evaluation of Efficacy and Patient Acceptance of Sound Amplifier Téo First, in Mild and Moderate Presbycusis Patient 60 Years of Age and Older, With no Previous Hearing Aid. Completed NCT01815788
12 Neurological Treatment to Improve the Hearing in Noise Abilities of Older Adults With Hearing Impairments. Completed NCT02147847
13 At-home Auditory Training Clinical Trial Completed NCT01950013
14 Clinical and Imaging Biomarkers of Audiovestibular Function in Infratentorial Superficial Siderosis Completed NCT04200664
15 Speech-in-Noise Measures as a Predictor of Hearing Aid Outcomes Completed NCT00371449
16 Characterizing Variability in Hearing Aid Outcomes Among Older Adults Completed NCT02448706
17 Pilot Study of the Links Between Presbyacusis and Lexical Disorders in Patients With Alzheimer's Disease or Related Disease Completed NCT03638323
18 Assessment of e-Audiology for Providing Clinical Services and Support for Age-related Hearing Loss: A Pilot Study Completed NCT04048460
19 Genetic Study of Age Related Hearing Loss Completed NCT01732289 Early Phase 1
20 Evaluating Hearing Aid Service Delivery Models Completed NCT01788423
21 Investigation Of the Effects Of Dual-Task And Single-Task Training In Older Adults With Age-Related Hearing Loss Completed NCT05190081
22 Assessment of Age-related Hearing Loss in HIV-1 Patients Completed NCT02154971
23 Immediate Effects of Personal Sound Amplification Products on Speech Processing Completed NCT05076045
24 The Baltimore HEARS Pilot Study: Hearing Health Care Equality Through Accessible Research & Solutions Completed NCT02045511
25 Baltimore HEARS Study: Addressing Hearing Impairment and Social Engagement Through Community-delivered Hearing Care Completed NCT03442296
26 Consequences of Aging and Dirtying of Microphones on the Performances of Cochlear Implants. Influence of Signal Coding Completed NCT02369718
27 Adaptation and Pilot Implementation of the Family Check-Up for Deaf and Hard of Hearing Children Completed NCT03483428
28 A Parent-Directed, Multimedia Early Intervention Tool to Improve Outcomes in Underserved Children Who Are Deaf or Hard-of-Hearing Completed NCT01753661
29 Study of the Association Between Presbycusis With the Incidence of Frailty. Intake of Polyphenols for the Prevention of Presbycusis: Effects on Frailty Recruiting NCT04360109
30 Mitochondrial Genetics of Presbycusis Recruiting NCT03720964
31 Impact of Hearing Aid Intervention on Individuals With Cognitive Disorders Recruiting NCT04049643
32 Cost-effective Hearing Aid Delivery Models: Outcomes, Value, and Candidacy Recruiting NCT03579563
33 Impact of Auditory Stimulation in Eating Pleasure : Multicentric Study With Biscuits With Crunchy Texture vs Soft Texture in 100 Seniors Affected or at Risk of Presbyacusis Recruiting NCT04923087
34 Longitudinal Outcomes of Over-the-Counter Hearing Aids Recruiting NCT04030299
35 Evaluation of Unilateral vs Bilateral Hearing Aids for the Treatment of Age-related Hearing Loss Recruiting NCT04739436
36 HearCARE: Hearing for Communication and Resident Engagement Recruiting NCT04575051
37 Evaluation of the Hearing Aids Efficacy in Elderly Subjects: a Protocol for Multiparametric Longitudinal Study Recruiting NCT04333043
38 Development of a Battery of Audiological Tests for the Precision Diagnosis of Age-related Hearing Loss Recruiting NCT05312983
39 Longitudinal Evaluation of Hearing Aids Rehabilitation Within Age-related Hearing Loss Population : Behavioral and Neuroimaging PET Evaluations. Recruiting NCT05331404
40 Training Cognition to Improve Mobility and Listening in Older Adults With Hearing Loss: Moving From Lab to Life Recruiting NCT05418998
41 Improving Outcomes Using Augmentative and Alternative Communication for Children Who Are Deaf or Hard of Hearing Recruiting NCT02998164
42 Behavioral Parent Training for Families With Deaf and Hard of Hearing Preschoolers Recruiting NCT03916146
43 Technology-assisted Language Intervention for Children Who Are Deaf/Hard-of-hearing (TALI) Recruiting NCT04857255
44 Teletherapy to Address Language Disparities in Deaf and Hard-of-hearing Children Recruiting NCT04928209
45 Hearing Loss and Communication Needs in a Group Care Setting for Older Adults Active, not recruiting NCT04659967
46 Effects of Huperzine A on Presbycusis-related Subjective Tinnitus and Cognitive Impairment Enrolling by invitation NCT03101722 BTHE and Huperzine A
47 Evaluation of the Impact of Cochlear Implants on Cognition in Older Adults Enrolling by invitation NCT02729402
48 Increasing Word Learning Efficiency in Children Who Are Deaf and Hard of Hearing Through Retrieval Practice Not yet recruiting NCT05512000
49 Effects of Cognitive Training on Age-Related Hearing Loss and Speech Perception Terminated NCT02294812
50 Objective Measurement of Hearing Aid Benefit Withdrawn NCT04431622

Search NIH Clinical Center for Age-Related Hearing Loss

Genetic Tests for Age-Related Hearing Loss

Anatomical Context for Age-Related Hearing Loss

Organs/tissues related to Age-Related Hearing Loss:

MalaCards : Cortex, Kidney, Brain, Bone, Cingulate Cortex, Eye, T Cells

Publications for Age-Related Hearing Loss

Articles related to Age-Related Hearing Loss:

(show top 50) (show all 3829)
# Title Authors PMID Year
Genome-wide DNA methylation analysis of middle-aged and elderly monozygotic twins with age-related hearing loss in Qingdao, China. 62
36179964 2023
Cognitive, physical, and mental profiles of older adults with misplaced self-evaluation of hearing loss. 62
36116286 2023
Drinking to cope and coping strategies in Deaf/Hard of hearing college students. 62
36087499 2023
Influence of perceived discrimination on problematic smartphone use among Chinese deaf and hard-of-hearing students: Serial mediating effects of sense of security and social avoidance. 62
36055057 2023
Caregiver Experiences With Oral Bilingualism in Children Who Are Deaf and Hard of Hearing in the United States: Impact on Child Language Proficiency. 62
36472940 2022
"None of it was especially easy": improving COVID-19 vaccine equity for people with disabilities. 62
35419700 2022
Degree centrality and functional connections in presbycusis with and without cognitive impairments. 62
36327020 2022
An emerging role for stress granules in neurodegenerative disease and hearing loss. 62
36384053 2022
Sustainable employability of teachers with hearing loss. 62
34807796 2022
Network pharmacology and experimental evidence reveal the protective mechanism of Yi-Qi Cong-Ming decoction on age-related hearing loss. 62
35938504 2022
Clinical Impact of Genetic Diagnosis of Sensorineural Hearing Loss in Adults. 62
36190904 2022
Post-translational modifications and age-related hearing loss. 62
36215796 2022
Vestibular and cochlear dysfunction in aging: Two sides of the same coin? 62
36474668 2022
The possible role of early-stage phase-locked neural activities in speech-in-noise perception in human adults across age and hearing loss. 62
36436293 2022
Association between age-related hearing loss with tinnitus and cognitive performance in older community-dwelling Chinese adults. 62
36075585 2022
Age-related High-frequency Hearing Loss Is Not Associated With Horizontal Semicircular Canal Function. 62
35696183 2022
A Systematic Review of the Literature Between 2009 and 2019 to Identify and Evaluate Publications on the Effects of Age-Related Hearing Loss on Speech Processing. 62
36397662 2022
Is age-related hearing loss a potentially modifiable risk factor for dementia? 62
36410369 2022
Linking Cerebrovascular Dysfunction to Age-Related Hearing Loss and Alzheimer's Disease-Are Systemic Approaches for Diagnosis and Therapy Required? 62
36421731 2022
Etiology, Comorbidities, and Health Service Use in a Clinical Cohort of Children With Hearing Loss. 62
35943238 2022
Older adults' neural tracking of interrupted speech is a function of task difficulty. 62
35995377 2022
Effect of statin on age-related hearing loss via drug repurposing. 62
35963547 2022
Melatonin prevents age-related hearing loss in the murin experimental model. 62
35780011 2022
Sound energy absorbance changes in the elderly with presbycusis with normal outer and middle ear. 62
36350367 2022
Hearing Health Outcomes as a Function of Age, Gender, and Diversity. 62
36466563 2022
Coprevalence of Presbycusis and Its Effect on Outcome of Voice Therapy in Patients With Presbyphonia. 62
33067119 2022
The association between hearing threshold and urinary personal care and consumer product metabolites in middle-aged and elderly people from the USA. 62
35731440 2022
Adenovirus-mediated SIRT1 protects cochlear strial marginal cells in a D-gal-induced senescent model in vitro. 62
36350417 2022
Effects of Diet and Lifestyle on Audio-Vestibular Dysfunction in the Elderly: A Literature Review. 62
36432406 2022
Co-viewing an Educational Video: A Pilot Study About Mother-DHH Child Interaction. 62
36436513 2022
How Many People Use Sign Language? A National Health Survey-Based Estimate. 62
36423340 2022
Influence of gender on people with disabilities' work relationships: prospects for ergonomics interventions. 62
35188087 2022
Development and Implementation of a Curriculum for Pediatric Trainees on Caring for Children Who Are Deaf and Hard of Hearing: A Pilot Study. 62
36217055 2022
Acceptance and Action Questionnaire-Adult Hearing Loss (AAQ-AHL): validation with hearing aid users. 62
36373617 2022
Developing an Evidence-Based Military Auditory Fitness-for-Duty Standard Based on the 80-Word Modified Rhyme Test. 62
36323655 2022
Emergency department condition acuity, length of stay, and revisits among deaf and hard-of-hearing patients: A retrospective chart review. 62
35904003 2022
Impact of communication modality on caregiver ratings for deaf and hard of hearing children. 62
34024209 2022
Accommodating hearing loss in outpatient physician offices in the U.S. 62
36376146 2022
Translation and Cross-Cultural Adaptation of the "Early Support Monitoring Protocol". 62
36221903 2022
Somatosensory gating is related to behavioral and verbal outcomes in children with mild-to-severe hearing loss. 62
36310092 2022
Educational Environments and Secondary School Outcomes Among Students Who Are D/deaf and Hard of Hearing in Special Education. 62
35952405 2022
Behavioral Parent Training for Families With Young Deaf or Hard of Hearing Children Followed in Hearing Health Care. 62
35985319 2022
Supporting the Social-Emotional Well-Being of Elementary School Students Who Are Deaf and Hard of Hearing: A Pilot Study. 62
35914020 2022
Provider Perspectives: Identification and Follow-up of Infants who Are Deaf or Hard of Hearing. 62
36037854 2022
Eye-Movement Deficits in Seniors with Hearing Aids: Cognitive and Multisensory Implications. 62
36358352 2022
AAV-ie-mediated UCP2 overexpression accelerates inner hair cell loss during aging in vivo. 62
36266633 2022
Decreased modulation of population correlations in auditory cortex is associated with decreased auditory detection performance in old mice. 62
36302637 2022
Effect of Aging on Speech Discrimination. 62
36111451 2022
Noise overstimulation of young adult UMHET4 mice accelerates age-related hearing loss. 62
36126618 2022
Cochlear Neurotrophin-3 overexpression at mid-life prevents age-related inner hair cell synaptopathy and slows age-related hearing loss. 62
36088647 2022

Variations for Age-Related Hearing Loss

Expression for Age-Related Hearing Loss

Search GEO for disease gene expression data for Age-Related Hearing Loss.

Pathways for Age-Related Hearing Loss

GO Terms for Age-Related Hearing Loss

Sources for Age-Related Hearing Loss

8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
27 GO
28 GTR
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
36 LifeMap
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
70 Tocris
72 UMLS via Orphanet
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