Aliases & Classifications for Age-Related Hearing Loss

MalaCards integrated aliases for Age-Related Hearing Loss:

Name: Age-Related Hearing Loss 25
Presbycusis 25 73
Old-Aged Sensorineural Hearing Impairment 25
Age-Related Hearing Impairment 25
Hearing Loss, Age-Related 25
Deafness Due to Old Age 25
Presbyacusia 25

Classifications:



External Ids:

ICD10 33 H91.1
UMLS 73 C0033074

Summaries for Age-Related Hearing Loss

Genetics Home Reference : 25 Age-related hearing loss (also known as presbycusis) is a decrease in hearing ability that happens with age. In most cases, the hearing loss affects both ears. It can begin as early as a person's thirties or forties and worsens gradually over time.

MalaCards based summary : Age-Related Hearing Loss, also known as presbycusis, is related to age-related hearing impairment 1 and age-related hearing impairment 2, and has symptoms including tinnitus An important gene associated with Age-Related Hearing Loss is ARHI2 (Age-Related Hearing Impairment 2), and among its related pathways/superpathways is Mitophagy - animal. The drugs Citalopram and Dopamine have been mentioned in the context of this disorder. Affiliated tissues include cortex, testes and bone, and related phenotype is limbs/digits/tail.

Related Diseases for Age-Related Hearing Loss

Graphical network of the top 20 diseases related to Age-Related Hearing Loss:



Diseases related to Age-Related Hearing Loss

Symptoms & Phenotypes for Age-Related Hearing Loss

UMLS symptoms related to Age-Related Hearing Loss:


tinnitus

MGI Mouse Phenotypes related to Age-Related Hearing Loss:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 limbs/digits/tail MP:0005371 8.92 APOE GRM7 HIF1A SETD2

Drugs & Therapeutics for Age-Related Hearing Loss

Drugs for Age-Related Hearing Loss (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 45)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Citalopram Approved Phase 4 59729-33-8 2771
2
Dopamine Approved Phase 4 51-61-6, 62-31-7 681
3
Norepinephrine Approved Phase 4 51-41-2 439260
4 Serotonin and Noradrenaline Reuptake Inhibitors Phase 4
5 Antidepressive Agents, Second-Generation Phase 4
6 Analgesics Phase 4
7 Parasympatholytics Phase 4
8 Muscarinic Antagonists Phase 4
9 Cholinergic Antagonists Phase 4
10 Serotonin Agents Phase 4
11 Antidepressive Agents Phase 4
12 Duloxetine Hydrochloride Phase 4
13 Antiparkinson Agents Phase 4
14 Serotonin Uptake Inhibitors Phase 4
15 Psychotropic Drugs Phase 4
16 Peripheral Nervous System Agents Phase 4
17 Cholinergic Agents Phase 4,Not Applicable
18 Dopamine Agents Phase 4
19 Autonomic Agents Phase 4
20 Neurotransmitter Uptake Inhibitors Phase 4
21 Neurotransmitter Agents Phase 4,Not Applicable
22
Serotonin Investigational, Nutraceutical Phase 4 50-67-9 5202
23 Pharmaceutical Solutions Phase 1,Not Applicable
24
Polyestradiol phosphate Approved 28014-46-2
25
Estradiol Approved, Investigational, Vet_approved 50-28-2 5757
26 Estradiol valerate Approved, Investigational, Vet_approved 979-32-8
27
leucovorin Approved Not Applicable 58-05-9 6006 143
28
Huperzine A Approved, Experimental Not Applicable 102518-79-6
29
Folic Acid Approved, Nutraceutical, Vet_approved Not Applicable 59-30-3 6037
30 Estradiol 3-benzoate
31 Estradiol 17 beta-cypionate
32 Hormone Antagonists
33 Hormones, Hormone Substitutes, and Hormone Antagonists
34 Hormones
35 Trace Elements Not Applicable
36 Vitamin B9 Not Applicable
37 Vitamin B Complex Not Applicable
38 Vitamins Not Applicable
39 Micronutrients Not Applicable
40 Hematinics Not Applicable
41 Folate Not Applicable
42 Hemostatics Not Applicable
43 Cholinesterase Inhibitors Not Applicable
44 Neuroprotective Agents Not Applicable
45 Protective Agents Not Applicable

Interventional clinical trials:

(show all 32)
# Name Status NCT ID Phase Drugs
1 Treating Hearing Loss to Improve Mood and Cognition in Older Adults Recruiting NCT03321006 Phase 4 Duloxetine
2 Caroverin and Inner Ear Diseases Suspended NCT01174979 Phase 3 Caroverin
3 Efficacy and Safety of AUT00063 Versus Placebo in Age-Related Hearing Loss Completed NCT02345031 Phase 2 AUT00063;Placebo
4 A Study Of The Effects Of PF-04958242 In Subjects With Age-Related Hearing Loss Completed NCT01518920 Phase 1 PF-04958242;PF-04958242;Placebo
5 Use of Hearing Aids. Development and Implementation of a Counselling Program for Hearing Aid Users Unknown status NCT02233361 Not Applicable
6 Genetic Study of Age Related Hearing Loss Completed NCT01732289 Early Phase 1
7 Evaluation of Efficacy and Patient Acceptance of Sound Amplifier Téo First, in Mild and Moderate Presbycusis Patient 60 Years of Age and Older, With no Previous Hearing Aid Completed NCT01815788 Not Applicable
8 Clinical Trial on Alzheimer Disease, Presbycusis and Hearing Aids Completed NCT00488007 Not Applicable
9 Neural Changes in the Aging Auditory System Completed NCT00264407 Hormone Replacement Therapy - HRT
10 Computer-Based Auditory Rehabilitation Completed NCT02147847 Not Applicable
11 Evaluating Hearing Aid Service Delivery Models Completed NCT01788423 Not Applicable
12 At-home Auditory Training Clinical Trial Completed NCT01950013 Not Applicable
13 Variability In Hearing Aid Outcomes In Older Adults Completed NCT02448706 Not Applicable
14 Predicting Success With Hearing Aids Completed NCT00371449
15 The Effect of Folic Acid on Atherosclerosis, Cognitive Performance and Hearing Completed NCT00110604 Not Applicable
16 Validation of uHear™ as a Screening Tool to Detect Hearing Impairment in Elderly Cancer Patients Within a Comprehensive Geriatric Assessment Completed NCT02381782
17 Surgical Optimizing of a Middle Ear Implant (MET )With Laser Velocimetry in Patients With Moderate to Severe Hearing Loss in Case of Failure of Conventional Equipment Completed NCT02845115 Not Applicable
18 The Baltimore HEARS Pilot Study Completed NCT02045511 Not Applicable
19 PC-Based Rehabilitation of Auditory Function Completed NCT00724347 Not Applicable
20 Age-related Hearing Loss and Lexical Disorders Recruiting NCT03638323
21 The RBANS-H in Older Adults With Normal Hearing or Age-related Hearing Loss Recruiting NCT03208608
22 Assessment of Age-related Hearing Loss in HIV-1 Patients Recruiting NCT02154971
23 Baltimore HEARS: Hearing Equality Through Accessible Research & Solutions Recruiting NCT03442296 Not Applicable
24 Neuroplasticity in Auditory Aging_Project 2 Recruiting NCT03475043 Not Applicable
25 Auditory Temporal Processes in Aging Recruiting NCT03468660 Not Applicable
26 Auditory Rehabilitation and Cognition in Alzheimer Patients Recruiting NCT03002142 Not Applicable
27 Hearing Aid Education and Adaptation System Recruiting NCT02839759 Not Applicable
28 Effects of Cognitive Training on Speech Perception Active, not recruiting NCT02294812 Not Applicable
29 Effects of Hearing Rehabilitative Interventions and Huperzine A on Presbycusis(Δ,kHz, dB,MMSE, AD) Enrolling by invitation NCT03101722 Not Applicable Huperzine A
30 Evaluation of the Impact of Cochlear Implants on Cognition in Older Adults Enrolling by invitation NCT02729402 Not Applicable
31 Mitochondrial Genetics of Presbycusis Not yet recruiting NCT03720964
32 Cost-effective Hearing Aid Delivery Models Not yet recruiting NCT03579563 Not Applicable

Search NIH Clinical Center for Age-Related Hearing Loss

Genetic Tests for Age-Related Hearing Loss

Anatomical Context for Age-Related Hearing Loss

MalaCards organs/tissues related to Age-Related Hearing Loss:

41
Cortex, Testes, Bone, Brain, T Cells, Thymus, Thyroid

Publications for Age-Related Hearing Loss

Articles related to Age-Related Hearing Loss:

(show top 50) (show all 474)
# Title Authors Year
1
Functional Change in the Caudal Pontine Reticular Nucleus Induced by Age-Related Hearing Loss. ( 29853848 )
2018
2
Audio-visual speech processing in age-related hearing loss: Stronger integration and increased frontal lobe recruitment. ( 29655940 )
2018
3
Serum uric acid and prevalence of age-related hearing loss in the Japanese population: Baseline data from the Aidai Cohort Study in Yawatahama. ( 29339204 )
2018
4
Loss of IDH2 Accelerates Age-related Hearing Loss in Male Mice. ( 29567975 )
2018
5
Age-related hearing loss: Unraveling the pieces. ( 29721536 )
2018
6
Whole-genome sequencing reveals new insights into age-related hearing loss: cumulative effects, pleiotropy and the role of selection. ( 29725052 )
2018
7
Age-Related Hearing Loss and Its Association with Depression in Later Life. ( 29752060 )
2018
8
Mutations in L-type amino acid transporter-2 support<i>SLC7A8</i>as a novel gene involved in age-related hearing loss. ( 29355479 )
2018
9
Age-Related Hearing Loss: Innovations in Hearing Augmentation. ( 29735277 )
2018
10
Sex bias in basic and preclinical age-related hearing loss research. ( 29898787 )
2018
11
Codeficiency of Lysosomal Mucolipins 3 and 1 in Cochlear Hair Cells Diminishes Outer Hair Cell Longevity and Accelerates Age-Related Hearing Loss. ( 29453205 )
2018
12
Heritability of Age-Related Hearing Loss in Middle-Aged and Elderly Chinese: A Population-Based Twin Study. ( 29794565 )
2018
13
Age-related hearing loss and communication at a PACE Day Health Center. ( 29526596 )
2018
14
Self-Stigma and Age-Related Hearing Loss: A Qualitative Study of Stigma Formation and Dimensions. ( 29379957 )
2018
15
Association of Age-Related Hearing Loss With Cognitive Function, Cognitive Impairment, and Dementia: A Systematic Review and Meta-analysis. ( 29222544 )
2018
16
How do aging and age-related hearing loss affect the ability to communicate effectively in challenging communicative conditions? ( 29941310 )
2018
17
Robust Neuronal Discrimination in Primary Auditory Cortex Despite Degradations of Spectro-temporal Acoustic Details: Comparison Between Guinea Pigs with Normal Hearing and Mild Age-Related Hearing Loss. ( 29302822 )
2018
18
Age-Related Hearing Loss. ( 30291149 )
2018
19
The World Health Organization's hearing-impairment grading system: an evaluation for unaided communication in age-related hearing loss. ( 30318941 )
2018
20
Association of Age-Related Hearing Loss With Multiple Adverse Health Outcomes. ( 30419115 )
2018
21
Association of Audiometric Age-Related Hearing Loss With Depressive Symptoms Among Hispanic Individuals. ( 30520955 )
2018
22
Considering Age-Related Hearing Loss in Neuropsychological Practice: Findings from a Feasibility Study. ( 30522534 )
2018
23
Rs1894720 polymorphism in MIAT increased susceptibility to age-related hearing loss by modulating the activation of miR-29b/SIRT1/PGC-1α signaling. ( 30556210 )
2018
24
The impact of age-related hearing loss and lateralized auditory attention on spatiotemporal parameters of gait during dual-tasking among community dwelling older adults. ( 30056101 )
2018
25
N-acetylcysteine Treatment Reduces Age-related Hearing Loss and Memory Impairment in the Senescence-Accelerated Prone 8 (SAMP8) Mouse Model. ( 30090654 )
2018
26
An Oral Combination of Vitamins A, C, E, and Mg++ Improves Auditory Thresholds in Age-Related Hearing Loss. ( 30108480 )
2018
27
Age-related hearing loss and cognitive decline - The potential mechanisms linking the two. ( 30177417 )
2018
28
Next-generation sequencing identified SPATC1L as a possible candidate gene for both early-onset and age-related hearing loss. ( 30177775 )
2018
29
Transient-Evoked Otoacoustic Emissions Reflect Audiometric Patterns of Age-Related Hearing Loss. ( 30198420 )
2018
30
A Tipping Point in Listening Effort: Effects of Linguistic Complexity and Age-Related Hearing Loss on Sentence Comprehension. ( 30235973 )
2018
31
Tuberous sclerosis complex-mediated mTORC1 overactivation promotes age-related hearing loss. ( 30247156 )
2018
32
Association between age‑related hearing loss and cognitive decline in C57BL/6J mice. ( 29901198 )
2018
33
Down-expression of P2RX2, KCNQ5, ERBB3 and SOCS3 through DNA hypermethylation in elderly women with presbycusis. ( 29325454 )
2018
34
Polymorphisms in folate metabolism genes are associated with susceptibility to presbycusis. ( 29369772 )
2018
35
MicroRNAs and Presbycusis. ( 29392088 )
2018
36
Presbycusis Disrupts Spontaneous Activity Revealed by Resting-State Functional MRI. ( 29593512 )
2018
37
Cholinergic Hypofunction in Presbycusis-Related Tinnitus With Cognitive Function Impairment: Emerging Hypotheses. ( 29681847 )
2018
38
Extending the Ear-Kidney Association to Presbycusis. ( 29710133 )
2018
39
Human Superior Olivary Nucleus Neuron Populations in Subjects With Normal Hearing and Presbycusis. ( 29862839 )
2018
40
Cognitive Decline, Dementia, Alzheimer's Disease and Presbycusis: Examination of the Possible Molecular Mechanism. ( 29937713 )
2018
41
CDH23 Methylation Status and Presbycusis Risk in Elderly Women. ( 30131691 )
2018
42
Cx26 partial loss causes accelerated presbycusis by redox imbalance and dysregulation of Nfr2 pathway. ( 30199819 )
2018
43
Age-associated decline in Nrf2 signaling and associated mtDNA damage may be involved in the degeneration of the auditory cortex: Implications for central presbycusis. ( 30272261 )
2018
44
Gray Matter Atrophy Is Associated With Cognitive Impairment in Patients With Presbycusis: A Comprehensive Morphometric Study. ( 30405333 )
2018
45
Age-Related Hearing Loss and Communication Breakdown in the Clinical Setting. ( 28837709 )
2017
46
Otoprotective effects of ethosuximide in NOD/LtJ mice with age-related hearing loss. ( 28560432 )
2017
47
NLRP3-inflammasomes are triggered by age-related hearing loss in the inner ear of mice. ( 29312513 )
2017
48
The miR-34a/Bcl-2 Pathway Contributes to Auditory Cortex Neuron Apoptosis in Age-Related Hearing Loss. ( 28817812 )
2017
49
Resolution of Cochlear Inflammation: Novel Target for Preventing or Ameliorating Drug-, Noise- and Age-related Hearing Loss. ( 28736517 )
2017
50
Activation of miR-34a impairs autophagic flux and promotes cochlear cell death via repressing ATG9A: implications for age-related hearing loss. ( 28981097 )
2017

Variations for Age-Related Hearing Loss

Expression for Age-Related Hearing Loss

Search GEO for disease gene expression data for Age-Related Hearing Loss.

Pathways for Age-Related Hearing Loss

Pathways related to Age-Related Hearing Loss according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.44 ATG9A HIF1A

GO Terms for Age-Related Hearing Loss

Biological processes related to Age-Related Hearing Loss according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of gene expression GO:0010468 9.5 APOE HIF1A SETD2
2 negative regulation of vascular smooth muscle cell proliferation GO:1904706 9.37 MIR34A SOD2
3 triglyceride homeostasis GO:0070328 9.26 APOE MIR34A
4 positive regulation of nitric-oxide synthase activity GO:0051000 9.16 APOE HIF1A
5 negative regulation of neuron apoptotic process GO:0043524 9.13 APOE HIF1A SOD2
6 oxygen homeostasis GO:0032364 8.62 HIF1A SOD2

Sources for Age-Related Hearing Loss

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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