Age-Related Hearing Loss

Categories: Ear diseases, Neuronal diseases

Aliases & Classifications for Age-Related Hearing Loss

MalaCards integrated aliases for Age-Related Hearing Loss:

Name: Age-Related Hearing Loss 43
Presbycusis 43 71 32
Age-Related Hearing Impairment 43 17
Old-Aged Sensorineural Hearing Impairment 43
Hearing Loss, Age-Related 43
Deafness Due to Old Age 43
Presbyacusia 43


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ICD10 32 H91.1
UMLS 71 C0033074

Summaries for Age-Related Hearing Loss

MedlinePlus Genetics : 43 Age-related hearing loss (also known as presbycusis) is a decrease in hearing ability that happens with age. In most cases, the hearing loss affects both ears. It can begin as early as a person's thirties or forties and worsens gradually over time.Age-related hearing loss first affects the ability to hear high-frequency sounds, such as speech. Affected people find it increasingly difficult to understand what others are saying, particularly when there is background noise (such as at a party). However, because the hearing loss is gradual, many people do not realize they cannot hear as well as they used to. They may turn up the television volume or start speaking louder without being aware of it.As the hearing loss worsens, it affects more frequencies of sound, making it difficult to hear more than just speech. Determining where a sound is coming from (localization) and identifying its source become more challenging. Some affected individuals also experience a ringing sensation in the ears (tinnitus) or dizziness and problems with balance (presbystasis).Age-related hearing loss often impacts a person's quality of life. Because affected individuals have trouble understanding speech, the condition affects their ability to communicate. It can contribute to social isolation, depression, and loss of self-esteem. Age-related hearing loss also causes safety issues if individuals become unable to hear smoke alarms, car horns, and other sounds that alert people to dangerous situations.

MalaCards based summary : Age-Related Hearing Loss, also known as presbycusis, is related to mild cognitive impairment and aging, and has symptoms including tinnitus An important gene associated with Age-Related Hearing Loss is ARHI1 (Age-Related Hearing Impairment 1), and among its related pathways/superpathways is NAD metabolism, sirtuins and aging. The drugs Citalopram and Dopamine have been mentioned in the context of this disorder. Affiliated tissues include cortex, t cells and endothelial, and related phenotypes are homeostasis/metabolism and limbs/digits/tail

Related Diseases for Age-Related Hearing Loss

Diseases in the Nonsyndromic Hearing Loss family:

Age-Related Hearing Loss

Diseases related to Age-Related Hearing Loss via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 100)
# Related Disease Score Top Affiliating Genes
1 mild cognitive impairment 30.3 MAPT APOE
2 aging 30.2 SOD2 SIRT1 HIF1A APOE
3 sleep disorder 30.0 MAPT HIF1A APOE
4 age-related hearing impairment 2 11.7
5 ataxia, combined cerebellar and peripheral, with hearing loss and diabetes mellitus 11.3
6 deafness, autosomal dominant 6 11.1
7 deafness, autosomal dominant 25 10.9
8 sensorineural hearing loss 10.6
9 branchiootic syndrome 1 10.5
10 hearing loss, noise-induced 10.5
11 dementia 10.4
12 subjective cognitive decline 10.3 MAPT APOE
13 posterior cortical atrophy 10.3 MAPT APOE
14 alzheimer disease 10 10.3 MAPT APOE
15 gerstmann syndrome 10.3 MAPT APOE
16 simultanagnosia 10.3 MAPT APOE
17 visual agnosia 10.3 MAPT APOE
18 ideomotor apraxia 10.3 MAPT APOE
19 nominal aphasia 10.3 MAPT APOE
20 alexia 10.3 MAPT APOE
21 agraphia 10.3 MAPT APOE
22 semantic dementia 10.3 MAPT APOE
23 binswanger's disease 10.3 MAPT APOE
24 deafness, autosomal dominant 28 10.3 GRM7 GRHL2
25 deafness, autosomal dominant 18 10.2 NAT2 GRHL2
26 alzheimer disease 7 10.2 MAPT APOE
27 arteriolosclerosis 10.2 MAPT APOE
28 dyscalculia 10.2 MAPT APOE
29 human immunodeficiency virus type 1 10.2
30 alzheimer disease 2 10.2 MAPT APOE
31 brain injury 10.2 MAPT APOE
32 body mass index quantitative trait locus 1 10.1
33 inclusion body myositis 10.1 MIR34A MAPT APOE
34 albinism-deafness syndrome 10.1
35 auditory system disease 10.1
36 hyperacusis 10.1
37 head injury 10.1
38 communicating hydrocephalus 10.1 MAPT APOE
39 inherited metabolic disorder 10.0 SIRT1 MIR34A APOE
40 parkinson disease, late-onset 10.0
41 wolfram syndrome 1 10.0
42 body mass index quantitative trait locus 11 10.0
43 deafness, autosomal dominant 5 10.0
44 body mass index quantitative trait locus 9 10.0
45 body mass index quantitative trait locus 8 10.0
46 body mass index quantitative trait locus 4 10.0
47 body mass index quantitative trait locus 10 10.0
48 body mass index quantitative trait locus 7 10.0
49 body mass index quantitative trait locus 12 10.0
50 body mass index quantitative trait locus 14 10.0

Comorbidity relations with Age-Related Hearing Loss via Phenotypic Disease Network (PDN):

Acute Cystitis Heart Disease
Hypertension, Essential Schizophreniform Disorder

Graphical network of the top 20 diseases related to Age-Related Hearing Loss:

Diseases related to Age-Related Hearing Loss

Symptoms & Phenotypes for Age-Related Hearing Loss

UMLS symptoms related to Age-Related Hearing Loss:


MGI Mouse Phenotypes related to Age-Related Hearing Loss:

# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.7 APOE ATG9A GRM7 HIF1A MAPT NAT2
2 limbs/digits/tail MP:0005371 9.17 APOE GRHL2 GRM7 HIF1A SETD2 SIRT1

Drugs & Therapeutics for Age-Related Hearing Loss

Drugs for Age-Related Hearing Loss (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 26)
# Name Status Phase Clinical Trials Cas Number PubChem Id
Citalopram Approved Phase 4 59729-33-8 2771
Dopamine Approved Phase 4 51-61-6, 62-31-7 681
Norepinephrine Approved Phase 4 51-41-2 439260
4 Neurotransmitter Agents Phase 4
5 Dopamine Agents Phase 4
6 Antidepressive Agents Phase 4
7 Serotonin and Noradrenaline Reuptake Inhibitors Phase 4
8 Psychotropic Drugs Phase 4
9 Duloxetine Hydrochloride Phase 4
10 Serotonin Uptake Inhibitors Phase 4
11 Analgesics Phase 4
Serotonin Investigational, Nutraceutical Phase 4 50-67-9 5202
Estradiol Approved, Investigational, Vet_approved 50-28-2 5757
Polyestradiol phosphate Approved 28014-46-2
Huperzine A Approved, Experimental 102518-79-6
Ethanol Approved 64-17-5 702
17 Hormone Antagonists
18 Hormones
19 Estradiol 3-benzoate
20 Estradiol 17 beta-cypionate
21 Anti-Retroviral Agents
22 Pharmaceutical Solutions
23 Protective Agents
24 Neuroprotective Agents
25 Cholinesterase Inhibitors
26 Cholinergic Agents

Interventional clinical trials:

(show all 34)
# Name Status NCT ID Phase Drugs
1 Sensation and Psychiatry: Linking Age-Related Hearing Loss to Late-Life Depression and Cognitive Decline Recruiting NCT03321006 Phase 4 Duloxetine or escitalopram
2 A Balanced, Randomized, Placebo-Controlled, Double-Blind Study of the Efficacy and Safety of AUT00063 Versus Placebo in Age-Related Hearing Loss [CLARITY-1 Study] Completed NCT02345031 Phase 2 AUT00063;Placebo
3 A Phase 1b, Prospective, Randomized, Double-Blind, Placebo-Controlled, Single-Dose, Multicenter, Safety Study of FX-322 Administered by Intratympanic Injection in Adults With Age-Related Sensorineural Hearing Loss Active, not recruiting NCT04601909 Phase 1 FX-322
4 The Repeatable Battery for the Assessment of Neuropsychological Status for Hearing Impaired Individuals (RBANS-H) in Older Adults With Normal Hearing or Age-related Hearing Loss Unknown status NCT03208608
5 Evaluation of the Impact of Cochlear Implants on Cognition in Older Adults Unknown status NCT02729402
6 Use of Hearing Aids. Development and Implementation of a Counselling Program for Hearing Aid Users. Unknown status NCT02233361
7 Evaluating Hearing Aid Service Delivery Models Completed NCT01788423
8 Impact of Hearing Aid Technology on Self-reported Outcomes in Patients With Presbycusis - a Randomized Controlled Trial Completed NCT04539847
9 Assessment of e-Audiology for Providing Clinical Services and Support for Age-related Hearing Loss: A Pilot Study Completed NCT04048460
10 Genetic Study of Age Related Hearing Loss Completed NCT01732289 Early Phase 1
11 Age-Related Hearing Loss: Presbycusis & Its Neural Bases Completed NCT00264407 Hormone Replacement Therapy - HRT
12 Assessment of Age-related Hearing Loss in HIV-1 Patients Completed NCT02154971
13 The Baltimore HEARS Pilot Study: Hearing Health Care Equality Through Accessible Research & Solutions Completed NCT02045511
14 Evaluation of Efficacy and Patient Acceptance of Sound Amplifier Téo First, in Mild and Moderate Presbycusis Patient 60 Years of Age and Older, With no Previous Hearing Aid. Completed NCT01815788
15 Clinical Trial on Cognitive, Behavioural, Quality of Life and Medico-economic Benefits of Hearing Aids in Alzheimer Disease Patients Suffering From Presbycusis Completed NCT00488007
16 Neurological Treatment to Improve the Hearing in Noise Abilities of Older Adults With Hearing Impairments. Completed NCT02147847
17 At-home Auditory Training Clinical Trial Completed NCT01950013
18 Speech-in-Noise Measures as a Predictor of Hearing Aid Outcomes Completed NCT00371449
19 Pilot Study of the Links Between Presbyacusis and Lexical Disorders in Patients With Alzheimer's Disease or Related Disease Completed NCT03638323
20 Characterizing Variability in Hearing Aid Outcomes Among Older Adults Completed NCT02448706
21 Evaluation of the Hearing Aids Efficacy in Elderly Subjects: a Protocol for Multiparametric Longitudinal Study Recruiting NCT04333043
22 Hearing Loss and Communication Needs in a Group Care Setting for Older Adults Recruiting NCT04659967
23 Mitochondrial Genetics of Presbycusis Recruiting NCT03720964
24 Cost-effective Hearing Aid Delivery Models: Outcomes, Value, and Candidacy Recruiting NCT03579563
25 Longitudinal Outcomes of Over-the-Counter Hearing Aids Recruiting NCT04030299
26 Impact of Hearing Aid Intervention on Individuals With Cognitive Disorders Recruiting NCT04049643
27 Clinical and Imaging Biomarkers of Audiovestibular Function in Infratentorial Superficial Siderosis Recruiting NCT04200664
28 Baltimore HEARS Study: Addressing Hearing Impairment and Social Engagement Through Community-delivered Hearing Care Active, not recruiting NCT03442296
29 Effects of Huperzine A on Presbycusis-related Subjective Tinnitus and Cognitive Impairment Enrolling by invitation NCT03101722 BTHE and Huperzine A
30 HearCARE: Hearing for Communication and Resident Engagement Not yet recruiting NCT04575051
31 Evaluation of Unilateral vs Bilateral Hearing Aids for the Treatment of Age-related Hearing Loss Not yet recruiting NCT04739436
32 Study of the Association Between Presbycusis With the Incidence of Frailty. Intake of Polyphenols for the Prevention of Presbycusis: Effects on Frailty Not yet recruiting NCT04360109
33 Objective Measurement of Hearing Aid Benefit Not yet recruiting NCT04431622
34 Effects of Cognitive Training on Age-Related Hearing Loss and Speech Perception Terminated NCT02294812

Search NIH Clinical Center for Age-Related Hearing Loss

Genetic Tests for Age-Related Hearing Loss

Anatomical Context for Age-Related Hearing Loss

MalaCards organs/tissues related to Age-Related Hearing Loss:

Cortex, T Cells, Endothelial, Bone Marrow, Thymus, Brain, Cingulate Cortex

Publications for Age-Related Hearing Loss

Articles related to Age-Related Hearing Loss:

(show top 50) (show all 1699)
# Title Authors PMID Year
The Association Between Early Age-Related Hearing Loss and Brain β-Amyloid. 61
32644260 2021
33273308 2021
33273310 2021
Aberrant brain functional hubs and causal connectivity in presbycusis. 61
32979169 2021
[The correlation between age-related hearing loss and cognitive impairment]. 61
33557494 2021
Association Between Central and Peripheral Age-Related Hearing Loss and Different Frailty Phenotypes in an Older Population in Southern Italy. 61
33570584 2021
BCL2 Interacting Protein 3-like/NIX-mediated Mitophagy Plays an Important Role in the Process of Age-related Hearing Loss. 61
33346118 2021
Expression of G9a in Auditory Cortex Is Downregulated in a Rat Model of Age-Related Hearing Loss. 61
32671696 2021
Expression of α2-Na/K-ATPase in C57BL/6J Mice Inner Ear and Its Relationship with Age-related Hearing Loss. 61
33582920 2021
Age-Related Hearing Loss, Neuropsychological Performance, and Incident Dementia in Older Adults. 61
33579835 2021
Genetics of Postlingual Sensorineural Hearing Loss. 61
32243624 2021
Auditory brainstem responses in aging dark agouti rats. 61
33506259 2021
Exacerbated age-related hearing loss in mice lacking the p43 mitochondrial T3 receptor. 61
33526032 2021
The Effect of Cognition on the Aided Benefit in Terms of Speech Understanding and Listening Effort Obtained With Digital Hearing Aids: A Systematic Review. 61
33524267 2021
Cognitive Hearing Science: Three Memory Systems, Two Approaches, and the Ease of Language Understanding Model. 61
33439747 2021
Age-related loss of auditory sensitivity in the zebrafish (Danio rerio). 61
33556775 2021
Utility and value of pre-operative CT and MRI for cochlear implantation in the elderly. 61
33460977 2021
Changes in Psychoacoustic Recognition and Brain Activity by Types of Fire Alarm. 61
33440710 2021
Neural links between facial emotion recognition and cognitive impairment in presbycusis. 61
33503682 2021
Impact of Cochlear Implantation on Neurocognitive Subdomains in Adult Cochlear Implant Recipients. 61
33440376 2021
Biophysical and morphological changes in inner hair cells and their efferent innervation in the ageing mouse cochlea. 61
33179774 2021
Physical Frailty, Multimorbidity, and All-Cause Mortality in an Older Population From Southern Italy: Results From the Salus in Apulia Study. 61
33493467 2021
Weakening of interaction networks with aging in tip-link protein induces hearing loss. 61
33270084 2021
When Hearing Does Not Mean Understanding: On the Neural Processing of Syntactically Complex Sentences by Listeners With Hearing Loss. 61
33400550 2021
Role of nutrition in the development and prevention of age-related hearing loss: A scoping review. 61
32473863 2021
Biased auditory nerve central synaptopathy is associated with age-related hearing loss. 61
33450070 2021
Biased synaptopathy as a central mechanism of age-related hearing loss. 61
33517580 2021
Age-related hearing loss associated with altered response efficiency and variability on a visual sustained attention task. 61
31868123 2021
Zone-specific damage of the olfactory epithelium under protein restriction. 61
33335225 2020
CYP1A1 and GSTs common gene variations and presbycusis risk: a genetic association analysis and a bioinformatics approach. 61
32712936 2020
Linking anatomical and physiological markers of auditory system degeneration with behavioral hearing assessments in a mouse (Mus musculus) model of age-related hearing loss. 61
32950782 2020
Gray matter declines with age and hearing loss, but is partially maintained in tinnitus. 61
33311548 2020
G6PD overexpression protects from oxidative stress and age-related hearing loss. 61
33222382 2020
Age-related hearing loss pertaining to potassium ion channels in the cochlea and auditory pathway. 61
33336302 2020
Age-related hearing loss and speech perception disorder: the broken interface between healthcare professionals and older adults. 61
32785895 2020
Impact of hearing loss on clinical interactions between older adults and health professionals: a systematic review. 61
32715404 2020
Smartphone-Based Applications to Detect Hearing Loss: A Review of Current Technology. 61
33341098 2020
Activation of the NRF2 pathway in Keap1-knockdown mice attenuates progression of age-related hearing loss. 61
33318486 2020
Neuroanatomical changes associated with age-related hearing loss and listening effort. 61
32960318 2020
Noise Damage Accelerates Auditory Aging and Tinnitus: A Canadian Population-Based Study. 61
32810017 2020
Toward a New Evidence-Based Fitting Paradigm for Over-the-Counter Hearing Aids. 61
33264578 2020
Ultrarare heterozygous pathogenic variants of genes causing dominant forms of early-onset deafness underlie severe presbycusis. 61
33229591 2020
Prevention and Rehabilitation of Old Age Deafness. 61
33088786 2020
The GoAudio Quantitative Mobile Audiology Test Enhances Access to Clinical Hearing Assessments. 61
33079580 2020
Ipsilateral Cochlear Implantation in the Presence of Observed and Irradiated Vestibular Schwannomas. 61
32551844 2020
[Research progress on pathogenesis and intervention of presbycusis]. 61
33210898 2020
Editorial: Special issue on presbycusis. 61
33229128 2020
Extended high frequency hearing and speech perception implications in adults and children. 61
32111404 2020
Emotional prosody perception in presbycusis patients after auditory rehabilitation. 61
33162354 2020
Relieving ferroptosis may partially reverse neurodegeneration of the auditory cortex. 61
32112499 2020

Variations for Age-Related Hearing Loss

Expression for Age-Related Hearing Loss

Search GEO for disease gene expression data for Age-Related Hearing Loss.

Pathways for Age-Related Hearing Loss

Pathways related to Age-Related Hearing Loss according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 9.66 SIRT1 HIF1A

GO Terms for Age-Related Hearing Loss

Biological processes related to Age-Related Hearing Loss according to GeneCards Suite gene sharing:

(show all 17)
# Name GO ID Score Top Affiliating Genes
1 regulation of gene expression GO:0010468 9.78 SETD2 HIF1A GRHL2 APOE
2 negative regulation of neuron apoptotic process GO:0043524 9.73 SOD2 HIF1A APOE
3 cellular response to hypoxia GO:0071456 9.7 SIRT1 MIR34A HIF1A
4 response to oxidative stress GO:0006979 9.67 SOD2 SIRT1 APOE
5 cholesterol homeostasis GO:0042632 9.58 SIRT1 MIR34A APOE
6 positive regulation of nitric-oxide synthase activity GO:0051000 9.57 HIF1A APOE
7 positive regulation of cholesterol efflux GO:0010875 9.55 SIRT1 APOE
8 positive regulation of cellular senescence GO:2000774 9.54 SIRT1 MIR34A
9 response to reactive oxygen species GO:0000302 9.51 HIF1A APOE
10 fatty acid homeostasis GO:0055089 9.46 SIRT1 APOE
11 negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway GO:1902176 9.43 SOD2 SIRT1
12 axonal transport of mitochondrion GO:0019896 9.37 MAPT HIF1A
13 cardiac ventricle morphogenesis GO:0003208 9.32 HIF1A GRHL2
14 positive regulation of smooth muscle cell differentiation GO:0051152 9.26 SIRT1 MIR34A
15 oxygen homeostasis GO:0032364 9.16 SOD2 HIF1A
16 negative regulation of gene expression GO:0010629 9.02 SIRT1 MIR34A MAPT HIF1A APOE
17 positive regulation of cAMP-dependent protein kinase activity GO:2000481 8.96 SPATC1L SIRT1

Molecular functions related to Age-Related Hearing Loss according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 enzyme binding GO:0019899 9.26 SOD2 SIRT1 MAPT HIF1A
2 nuclear hormone receptor binding GO:0035257 9.16 SIRT1 HIF1A
3 lipoprotein particle binding GO:0071813 8.62 MAPT APOE

Sources for Age-Related Hearing Loss

9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
31 HPO
32 ICD10
33 ICD10 via Orphanet
37 LifeMap
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
70 Tocris
72 UMLS via Orphanet
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