MCID: AGG003
MIFTS: 37

Aggressive Digital Papillary Adenocarcinoma

Categories: Cancer diseases, Skin diseases

Aliases & Classifications for Aggressive Digital Papillary Adenocarcinoma

MalaCards integrated aliases for Aggressive Digital Papillary Adenocarcinoma:

Name: Aggressive Digital Papillary Adenocarcinoma 12 15

Classifications:



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Disease Ontology 12 DOID:5590

Summaries for Aggressive Digital Papillary Adenocarcinoma

Disease Ontology : 12 A sweat gland carcinoma characterized by predominantly digital location with a high recurrence rate and metastatic potential.

MalaCards based summary : Aggressive Digital Papillary Adenocarcinoma is related to adenocarcinoma and paronychia. An important gene associated with Aggressive Digital Papillary Adenocarcinoma is S100B (S100 Calcium Binding Protein B), and among its related pathways/superpathways are Innate Immune System and Developmental Biology. Affiliated tissues include lung, breast and skin, and related phenotypes are Decreased viability and Decreased viability

Wikipedia : 77 Aggressive digital papillary adenocarcinoma is a cutaneous condition characterized by an aggressive... more...

Related Diseases for Aggressive Digital Papillary Adenocarcinoma

Diseases related to Aggressive Digital Papillary Adenocarcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 156)
# Related Disease Score Top Affiliating Genes
1 adenocarcinoma 30.5 FGFR2 HRAS KIT KRAS MUC1 PIK3CA
2 paronychia 30.4 HRAS KRAS
3 squamous cell carcinoma 29.5 FGFR2 HRAS MUC1 PDPN PIK3CA
4 papillary adenocarcinoma 10.9
5 eccrine papillary adenocarcinoma 10.9
6 localized hypertrophic neuropathy 10.4 MUC1 S100B
7 sclerosing perineurioma 10.4 MUC1 S100B
8 intracranial cysts 10.4 MUC1 S100B
9 spiradenoma 10.4 MUC1 S100B
10 non-functioning pituitary adenoma 10.4 MUC1 S100B
11 functioning pituitary adenoma 10.4 MUC1 S100B
12 epithelioid malignant peripheral nerve sheath tumor 10.4 MUC1 S100B
13 ossifying fibromyxoid tumor 10.4 MUC1 S100B
14 fibrous meningioma 10.4 MUC1 S100B
15 chordoid meningioma 10.4 MUC1 S100B
16 sinonasal undifferentiated carcinoma 10.4 CEACAM3 MUC1
17 eccrine porocarcinoma 10.4 MUC1 S100B
18 spindle cell rhabdomyosarcoma 10.4 MUC1 S100B
19 myxopapillary ependymoma 10.4 MUC1 S100B
20 monophasic synovial sarcoma 10.4 MUC1 S100B
21 chordoid glioma 10.4 MUC1 S100B
22 syringoma 10.4 MUC1 S100B
23 pleomorphic liposarcoma 10.3 MUC1 S100B
24 hidradenoma 10.3 MUC1 PIK3CA
25 rosette-forming glioneuronal tumor 10.3 PIK3CA S100B
26 anaplastic ependymoma 10.3 MUC1 S100B
27 rare adenocarcinoma of the breast 10.3 KRAS PIK3CA
28 sarcomatoid renal cell carcinoma 10.3 KIT MUC1
29 amelanotic melanoma 10.3 KIT S100B
30 perivascular epithelioid cell tumor 10.3 KIT MUC1
31 prostate adenoid cystic carcinoma 10.3 HRAS PIK3CA
32 chordoma 10.3 CEACAM3 MUC1 S100B
33 adenoma 10.3
34 thymoma, familial 10.3 HRAS KIT
35 ethmoid sinus cancer 10.2 HRAS PIK3CA
36 ethmoid sinus adenocarcinoma 10.2 HRAS PIK3CA
37 ovarian melanoma 10.2 HRAS KIT
38 reticular perineurioma 10.2 KIT MUC1 S100B
39 perineurioma 10.2 KIT MUC1 S100B
40 periampullary adenoma 10.2 HRAS KRAS
41 schimmelpenning-feuerstein-mims syndrome 10.2 HRAS KRAS
42 papilloma of choroid plexus 10.2 MUC1 S100B
43 neurofibroma 10.2 KIT MUC1 S100B
44 bile duct cysts 10.2 HRAS KRAS
45 papillary hidradenoma 10.2 KIT PIK3CA
46 syringocystadenoma papilliferum 10.2 KRAS MUC1 S100B
47 malignant peripheral nerve sheath tumor 10.2 KIT MUC1 S100B
48 mast-cell leukemia 10.2 KIT PIK3CA
49 rosai-dorfman disease 10.2 KRAS S100B
50 appendix disease 10.2 HRAS KRAS

Graphical network of the top 20 diseases related to Aggressive Digital Papillary Adenocarcinoma:



Diseases related to Aggressive Digital Papillary Adenocarcinoma

Symptoms & Phenotypes for Aggressive Digital Papillary Adenocarcinoma

GenomeRNAi Phenotypes related to Aggressive Digital Papillary Adenocarcinoma according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00055-A-2 9.91 HRAS KRAS PIK3CA MUC1
2 Decreased viability GR00106-A-0 9.91 KRAS
3 Decreased viability GR00221-A-1 9.91 HRAS KIT KRAS PIK3CA
4 Decreased viability GR00221-A-2 9.91 HRAS KRAS PIK3CA
5 Decreased viability GR00221-A-3 9.91 HRAS
6 Decreased viability GR00221-A-4 9.91 PIK3CA
7 Decreased viability GR00301-A 9.91 KIT KRAS
8 Decreased viability GR00381-A-1 9.91 KRAS
9 Decreased viability GR00402-S-2 9.91 HRAS KIT KRAS PIK3CA MUC1
10 Decreased cell migration GR00055-A-1 9.26 HRAS KRAS MUC1 PIK3CA

MGI Mouse Phenotypes related to Aggressive Digital Papillary Adenocarcinoma:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 integument MP:0010771 9.5 FGFR2 HRAS KIT KRAS PDPN PIK3CA
2 neoplasm MP:0002006 9.02 FGFR2 HRAS KIT KRAS PIK3CA

Drugs & Therapeutics for Aggressive Digital Papillary Adenocarcinoma

Search Clinical Trials , NIH Clinical Center for Aggressive Digital Papillary Adenocarcinoma

Genetic Tests for Aggressive Digital Papillary Adenocarcinoma

Anatomical Context for Aggressive Digital Papillary Adenocarcinoma

MalaCards organs/tissues related to Aggressive Digital Papillary Adenocarcinoma:

42
Lung, Breast, Skin, Liver, Colon, Pancreas, Thyroid

Publications for Aggressive Digital Papillary Adenocarcinoma

Articles related to Aggressive Digital Papillary Adenocarcinoma:

(show all 44)
# Title Authors Year
1
Aggressive Digital Papillary Adenocarcinoma at Atypical Site. ( 30792586 )
2019
2
Gene expression profiling in aggressive digital papillary adenocarcinoma sheds light on the architecture of a rare sweat gland carcinoma. ( 30472730 )
2019
3
Highly variable clinical feature and course of aggressive digital papillary adenocarcinoma. ( 29194742 )
2018
4
The So-Called Aggressive Digital Papillary Adenocarcinoma Is Epithelial-Myoepithelial Carcinoma. ( 29384814 )
2018
5
Aggressive Digital Papillary Adenocarcinoma: Population-Based Analysis of Incidence, Demographics, Treatment, and Outcomes. ( 29578881 )
2018
6
Mohs Micrographic Surgery as a Digit-Sparing Treatment for Aggressive Digital Papillary Adenocarcinoma. ( 28291063 )
2017
7
Aggressive Digital Papillary Adenocarcinoma of the Hand Presenting as a Felon. ( 28421154 )
2017
8
Aggressive digital papillary adenocarcinoma: A clinicopathological study of 19 cases. ( 28495496 )
2017
9
Aggressive digital papillary adenocarcinoma: treatment with Mohs micrographic surgery and an update of the literature. ( 28832985 )
2017
10
Role of Radiotherapy in Aggressive Digital Papillary Adenocarcinoma. ( 27098633 )
2016
11
Papillary adnexal neoplasm (aggressive digital papillary adenocarcinoma) on the ankle of a 15-year-old girl: case report and review of literature from a pediatric perspective. ( 27535353 )
2016
12
Aggressive Digital Papillary Adenocarcinoma With Multiple Organ Metastases: A Case Report and Review of the Literature. ( 27870729 )
2016
13
Aggressive digital papillary adenocarcinoma - a rare malignant tumor of the sweat glands: two case reports and a review of the literature. ( 25848311 )
2015
14
Aggressive Digital Papillary Adenocarcinoma: Case Report of a Positive Sentinel Lymph Node and Discussion of Utility of Sentinel Lymph Node Biopsy. ( 25954845 )
2015
15
Next-generation sequencing reveals rare genomic alterations in aggressive digital papillary adenocarcinoma. ( 26386519 )
2015
16
Aggressive Digital Papillary Adenocarcinoma. ( 26576210 )
2015
17
Papillary eccrine adenoma should not be mistaken for aggressive digital papillary adenocarcinoma. ( 24274672 )
2014
18
Is aggressive digital papillary adenocarcinoma really aggressive digital papillary adenocarcinoma? ( 25126455 )
2014
19
Aggressive Digital Papillary Adenocarcinoma-A rare Entity Posing a Diagnostic Challenge. ( 25977623 )
2014
20
A case report of a rare adnexal tumour: aggressive digital papillary adenocarcinoma. ( 24964471 )
2013
21
The medial plantar flap vascularized by the reverse flow lateral plantar artery: a novel variation through the case of aggressive digital papillary adenocarcinoma of the sole. ( 22711199 )
2012
22
Aggressive digital papillary adenocarcinoma of the hand: an unsuspected malignant tumour of the sweat glands. ( 22747355 )
2012
23
Aggressive digital papillary adenocarcinoma. ( 21330762 )
2011
24
Aggressive Digital Papillary Adenocarcinoma in a Young Female-a Rare Presentation. ( 22654416 )
2011
25
Aggressive digital papillary adenocarcinoma: a review. ( 19874325 )
2010
26
Aggressive digital papillary adenocarcinoma diagnosed by fine needle aspiration cytology. ( 21187879 )
2010
27
Aggressive digital papillary adenocarcinoma: a report of two diseases and review of the literature. ( 18819728 )
2009
28
Human papillomavirus-58 and -73-associated digital squamous cell carcinoma in a patient with aggressive digital papillary adenocarcinoma. ( 19461243 )
2009
29
Aggressive digital papillary adenocarcinoma on the palm with pulmonary metastases. ( 18705837 )
2008
30
Aggressive digital papillary adenocarcinoma of the hand. ( 17306428 )
2007
31
Aggressive digital papillary adenocarcinoma: a silent malignancy masquerading as acquired digital fibrokeratoma. ( 17645380 )
2007
32
Lymphatic mapping and sentinel lymph node biopsy for staging of aggressive digital papillary adenocarcinoma. ( 16462393 )
2006
33
Aggressive Digital Papillary Adenocarcinoma in a 15-year-old Female. ( 16912593 )
2006
34
Aggressive digital papillary adenocarcinoma presenting as a paronychia of the finger. ( 16055244 )
2005
35
Digital papillary adenoma (ADPA) and aggressive digital papillary adenocarcinoma (AdPACa). ( 16314709 )
2005
36
Metastatic aggressive digital papillary adenocarcinoma. ( 12953940 )
2003
37
An aggressive treatment for aggressive digital papillary adenocarcinoma. ( 11926336 )
2002
38
Aggressive digital papillary adenocarcinoma presenting as finger infection. ( 12351985 )
2002
39
Aggressive digital papillary adenocarcinoma arising on the right great toe. ( 12370144 )
2002
40
Aggressive digital papillary adenocarcinoma: a case report and review of the literature. ( 11285414 )
2001
41
Aggressive digital papillary adenocarcinoma (aggressive digital papillary adenoma and adenocarcinoma revisited). ( 10843279 )
2000
42
Sentinel node biopsy for staging of aggressive digital papillary adenocarcinoma. ( 10848941 )
2000
43
Aggressive digital papillary adenocarcinoma of the foot: the clinicopathologic features of two cases. ( 11131478 )
2000
44
Aggressive digital papillary adenocarcinoma. ( 2394851 )
1990

Variations for Aggressive Digital Papillary Adenocarcinoma

Expression for Aggressive Digital Papillary Adenocarcinoma

Search GEO for disease gene expression data for Aggressive Digital Papillary Adenocarcinoma.

Pathways for Aggressive Digital Papillary Adenocarcinoma

Pathways related to Aggressive Digital Papillary Adenocarcinoma according to GeneCards Suite gene sharing:

(show top 50) (show all 63)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.92 CEACAM3 FGFR2 HRAS KIT KRAS MUC1
2
Show member pathways
13.38 FGFR2 HRAS KIT KRAS KRT77 PIK3CA
3
Show member pathways
13.22 FGFR2 HRAS KIT KRAS MUC1 PIK3CA
4
Show member pathways
13.16 CEACAM3 CEACAM5 HRAS KRAS PDPN PIK3CA
5
Show member pathways
12.86 FGFR2 HRAS KIT KRAS PIK3CA
6
Show member pathways
12.78 FGFR2 HRAS KRAS PIK3CA
7
Show member pathways
12.7 FGFR2 HRAS KIT KRAS PIK3CA
8 12.67 FGFR2 HRAS KIT KRAS
9 12.67 FGFR2 HRAS KIT KRAS PIK3CA
10
Show member pathways
12.6 FGFR2 HRAS KRAS PIK3CA
11
Show member pathways
12.57 FGFR2 HRAS KIT KRAS PIK3CA
12 12.52 FGFR2 HRAS KRAS PIK3CA
13
Show member pathways
12.52 FGFR2 HRAS KIT KRAS PIK3CA
14
Show member pathways
12.49 FGFR2 HRAS KIT KRAS PIK3CA
15
Show member pathways
12.42 HRAS KRAS MUC1 PIK3CA
16
Show member pathways
12.38 FGFR2 HRAS KRAS PIK3CA
17
Show member pathways
12.31 FGFR2 HRAS KRAS PIK3CA
18
Show member pathways
12.3 FGFR2 HRAS KRAS PIK3CA
19
Show member pathways
12.26 HRAS KIT KRAS PIK3CA
20
Show member pathways
12.22 FGFR2 HRAS KIT KRAS PIK3CA
21 12.16 HRAS KRAS PIK3CA
22
Show member pathways
12.15 FGFR2 HRAS KRAS
23
Show member pathways
12.13 HRAS KRAS PIK3CA
24
Show member pathways
12.13 FGFR2 HRAS KRAS PIK3CA
25
Show member pathways
12.11 HRAS KRAS PIK3CA
26
Show member pathways
12.09 HRAS KIT PIK3CA
27 12.09 HRAS KRAS PIK3CA
28
Show member pathways
12.08 HRAS KRAS PIK3CA
29
Show member pathways
12.07 FGFR2 HRAS KRAS PIK3CA
30
Show member pathways
12.05 HRAS KRAS PIK3CA
31
Show member pathways
12.05 HRAS KRAS PIK3CA
32
Show member pathways
12 HRAS KRAS PIK3CA
33
Show member pathways
11.98 HRAS KRAS PIK3CA
34
Show member pathways
11.97 FGFR2 HRAS KRAS PIK3CA
35 11.96 HRAS KRAS PIK3CA
36 11.95 FGFR2 HRAS KRAS PIK3CA
37 11.92 HRAS KRAS PIK3CA
38 11.91 CEACAM3 CEACAM5 KIT
39 11.9 HRAS KRAS PIK3CA
40 11.9 HRAS KRAS PIK3CA
41
Show member pathways
11.9 FGFR2 HRAS KRAS PIK3CA
42 11.82 HRAS KRAS PIK3CA
43 11.81 FGFR2 HRAS KRAS PIK3CA
44 11.79 HRAS KRAS PIK3CA
45
Show member pathways
11.77 HRAS KRAS PIK3CA
46
Show member pathways
11.75 HRAS KRAS PIK3CA
47
Show member pathways
11.61 CEACAM3 CEACAM5 HRAS KRAS PIK3CA
48
Show member pathways
11.59 HRAS KRAS PIK3CA S100B
49
Show member pathways
11.38 HRAS KIT KRAS PIK3CA
50 11.27 FGFR2 HRAS KRAS PIK3CA

GO Terms for Aggressive Digital Papillary Adenocarcinoma

Cellular components related to Aggressive Digital Papillary Adenocarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 plasma membrane GO:0005886 9.28 CEACAM3 CEACAM5 FGFR2 HRAS KIT KRAS

Biological processes related to Aggressive Digital Papillary Adenocarcinoma according to GeneCards Suite gene sharing:

(show all 15)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of protein kinase B signaling GO:0051897 9.71 FGFR2 KIT PIK3CA
2 regulation of cell shape GO:0008360 9.69 KIT PDPN S100B
3 negative regulation of neuron apoptotic process GO:0043524 9.67 HRAS KRAS PIK3CA
4 cytokine-mediated signaling pathway GO:0019221 9.67 KIT KRAS MUC1 PIK3CA
5 positive regulation of MAPK cascade GO:0043410 9.65 FGFR2 HRAS KIT
6 regulation of multicellular organism growth GO:0040014 9.55 FGFR2 PIK3CA
7 positive regulation of cell proliferation GO:0008284 9.55 FGFR2 HRAS KIT KRAS S100B
8 regulation of long-term neuronal synaptic plasticity GO:0048169 9.52 HRAS KRAS
9 negative regulation of anoikis GO:2000811 9.46 CEACAM5 PIK3CA
10 stimulatory C-type lectin receptor signaling pathway GO:0002223 9.43 HRAS KRAS MUC1
11 positive regulation of phospholipase C activity GO:0010863 9.4 HRAS KIT
12 response to isolation stress GO:0035900 9.32 HRAS KRAS
13 phosphatidylinositol phosphorylation GO:0046854 9.13 PIK3CA
14 positive regulation of MAP kinase activity GO:0043406 9.13 HRAS KIT KRAS
15 MAPK cascade GO:0000165 8.92 FGFR2 HRAS KIT KRAS

Molecular functions related to Aggressive Digital Papillary Adenocarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nucleotide binding GO:0000166 9.26 FGFR2 HRAS KIT KRAS
2 phosphatidylinositol-4,5-bisphosphate 3-kinase activity GO:0046934 8.32 PIK3CA

Sources for Aggressive Digital Papillary Adenocarcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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