MCID: AGG001
MIFTS: 56

Aggressive Periodontitis

Categories: Bone diseases, Genetic diseases, Oral diseases

Aliases & Classifications for Aggressive Periodontitis

MalaCards integrated aliases for Aggressive Periodontitis:

Name: Aggressive Periodontitis 12 44 15
Periodontitis, Juvenile 73
Juvenile Periodontitis 12
Periodontitis Juvenile 55

Classifications:



External Ids:

Disease Ontology 12 DOID:1474
ICD10 33 K05.2
MeSH 44 D010520
SNOMED-CT 68 2624008 49965002
UMLS 73 C0031106

Summaries for Aggressive Periodontitis

Disease Ontology : 12 A periodontitis that is characterized by rapid attachment loss and bone destruction in the presence of little local factors such as dental plaque and dental calculus resulting in inflammation and a loss of periodontium.

MalaCards based summary : Aggressive Periodontitis, also known as periodontitis, juvenile, is related to diabetes mellitus and spondylitis. An important gene associated with Aggressive Periodontitis is PDON2 (Periodontitis, Localized Aggressive), and among its related pathways/superpathways are Innate Immune System and PEDF Induced Signaling. The drugs Ethinyl Estradiol and Moxifloxacin have been mentioned in the context of this disorder. Affiliated tissues include bone, neutrophil and monocytes, and related phenotypes are hematopoietic system and homeostasis/metabolism

Wikipedia : 76 Aggressive periodontitis describes a type of periodontal disease and includes two of the seven... more...

Related Diseases for Aggressive Periodontitis

Diseases in the Aggressive Periodontitis family:

Periodontitis, Aggressive, 1 Periodontitis, Aggressive, 2

Diseases related to Aggressive Periodontitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 349)
# Related Disease Score Top Affiliating Genes
1 diabetes mellitus 30.1 IL1A IL1B IL1RN IL6 TNF
2 spondylitis 29.9 IL1RN IL6 TNF
3 periodontitis, chronic 29.8 IL1B IL6 MMP1 MMP8 TNFSF11
4 pyoderma 29.8 CXCL8 MMP1 TNF
5 gingivitis 29.7 CXCL8 IL1A IL1B IL4 IL6 LTF
6 periodontosis 29.6 CXCL8 TLR4 TNF TNFSF11
7 endocarditis 29.6 CXCL8 FCGR2A IL10 IL6 TNF
8 periodontitis 29.6 CTSC CXCL8 FPR1 IL10 IL1A IL1B
9 arthritis 29.3 CXCL8 IL10 IL1A IL1B IL1RN IL6
10 periodontal disease 29.0 CTSC CXCL8 IL1A IL1B IL1RN IL6
11 rheumatoid arthritis 28.7 CXCL8 IL10 IL1A IL1B IL1RN IL4
12 susceptibility to localized juvenile periodontitis 12.2
13 periodontitis, aggressive, 1 11.6
14 papillon-lefevre syndrome 11.5
15 chronic follicular conjunctivitis 10.4 IL1A IL1B
16 skin conditions 10.4 IL1A TNF
17 rheumatoid lung disease 10.3 IL1B TNF
18 staphylococcal toxic shock syndrome 10.3 IL1B TNF
19 scleral disease 10.3 IL1RN TNF
20 transient hypogammaglobulinemia 10.3 IL10 TNF
21 angioimmunoblastic lymphadenopathy with dysproteinemia 10.3 IL6 TNF
22 critical limb ischemia 10.3 IL6 TNF
23 microscopic polyangiitis 10.3 IL10 TNF
24 multifocal choroiditis 10.3 IL10 TNF
25 punctate inner choroidopathy 10.3 IL10 TNF
26 pustulosis of palm and sole 10.3 IL1RN TNF
27 paraneoplastic syndromes 10.3 IL1B IL6
28 systemic onset juvenile idiopathic arthritis 10.3 IL1RN TNF
29 autoimmune vasculitis 10.3 IL1B IL4
30 leukomalacia 10.3 IL6 TNF
31 scorpion envenomation 10.3 IL6 TNF
32 cardiogenic shock 10.3 IL6 TNF
33 eye lymphoma 10.3 IL10 IL6
34 congenital hypogammaglobulinemia 10.3 IL1A IL4
35 acute cholangitis 10.3 IL1RN IL6
36 nickel allergic contact dermatitis 10.3 IL10 IL4
37 hyperlucent lung 10.3 IL10 IL4
38 cryopyrin-associated periodic syndrome 10.3 IL1RN IL6
39 autoimmune myocarditis 10.3 IL4 TNF
40 leukoregulin 10.3 CXCL8 IL1A
41 b-cell growth factor 10.3 IL4 IL6
42 vulvovaginitis 10.3 CXCL8 IL10
43 neurosyphilis 10.3 CXCL8 IL10
44 blepharoconjunctivitis 10.3 IL4 MMP8
45 familial mediterranean fever 10.3 IL1B IL1RN TNF
46 trench fever 10.3 TLR4 TNF
47 rheumatic disease 10.3 IL10 IL1B TNF
48 prosthetic joint infection 10.3 IL1B TLR4
49 intervertebral disc disease 10.3 IL1A IL1B IL6
50 demyelinating disease 10.3 IL10 IL1B TNF

Graphical network of the top 20 diseases related to Aggressive Periodontitis:



Diseases related to Aggressive Periodontitis

Symptoms & Phenotypes for Aggressive Periodontitis

MGI Mouse Phenotypes related to Aggressive Periodontitis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.18 CTSC FCGR2A FPR1 IL10 IL1A IL1B
2 homeostasis/metabolism MP:0005376 10.17 CTSC FPR1 IL10 IL1A IL1B IL1RN
3 immune system MP:0005387 10.13 CTSC FCGR2A FPR1 IL10 IL1A IL1B
4 integument MP:0010771 9.85 CTSC IL10 IL1A IL1B IL1RN IL4
5 neoplasm MP:0002006 9.65 IL10 IL1A IL1B IL6 LTF MMP1
6 skeleton MP:0005390 9.28 FCGR2A IL10 IL1B IL1RN IL4 IL6

Drugs & Therapeutics for Aggressive Periodontitis

Drugs for Aggressive Periodontitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 78)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ethinyl Estradiol Approved Phase 4 57-63-6 5991
2
Moxifloxacin Approved, Investigational Phase 4 354812-41-2, 151096-09-2 152946
3
Amoxicillin Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 26787-78-0 33613
4 Estradiol valerate Approved, Investigational, Vet_approved Phase 4 979-32-8
5
Metronidazole Approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 443-48-1 4173
6
Norgestimate Approved, Investigational Phase 4 35189-28-7 6540478
7
Polyestradiol phosphate Approved Phase 4 28014-46-2
8
Estradiol Approved, Investigational, Vet_approved Phase 4 50-28-2 5757
9
Chlorhexidine Approved, Vet_approved Phase 4 55-56-1 2713 9552079
10
Triclosan Approved, Investigational Phase 4 3380-34-5 5564
11 sodium fluoride Approved Phase 4 7681-49-4
12 Contraceptives, Oral, Combined Phase 4
13 Anti-Infective Agents Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
14 Contraceptives, Oral Phase 4
15 Antibiotics, Antitubercular Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
16 Estradiol 3-benzoate Phase 4
17 Norgestimate, ethinyl estradiol drug combination Phase 4
18 Antiprotozoal Agents Phase 4,Phase 2,Phase 3,Phase 1
19 Contraceptive Agents Phase 4
20 Anti-Bacterial Agents Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
21 Anesthetics Phase 4,Not Applicable
22 Estradiol 17 beta-cypionate Phase 4
23 Topoisomerase Inhibitors Phase 4
24 Nucleic Acid Synthesis Inhibitors Phase 4
25 Fluoroquinolones Phase 4
26 Antiparasitic Agents Phase 4,Phase 2,Phase 3,Phase 1
27 Chlorhexidine gluconate Phase 4
28 Cariostatic Agents Phase 4
29 Listerine Phase 4
30 Lipid Regulating Agents Phase 4
31 Protective Agents Phase 4
32 Antimetabolites Phase 4
33 Anti-Infective Agents, Local Phase 4
34 Hypolipidemic Agents Phase 4
35 Fluorides Phase 4
36 Anesthetics, Local Phase 4
37
Clarithromycin Approved Phase 2, Phase 3,Phase 3,Not Applicable 81103-11-9 84029
38
Aspirin Approved, Vet_approved Phase 2, Phase 3,Phase 3 50-78-2 2244
39 Cytochrome P-450 CYP3A Inhibitors Phase 2, Phase 3,Phase 3,Not Applicable
40 Cytochrome P-450 Enzyme Inhibitors Phase 2, Phase 3,Phase 3,Not Applicable
41 Omega 3 Fatty Acid Phase 2, Phase 3,Phase 3
42 Cyclooxygenase Inhibitors Phase 2, Phase 3,Phase 3
43 Anti-Inflammatory Agents, Non-Steroidal Phase 2, Phase 3,Phase 3
44 Analgesics, Non-Narcotic Phase 2, Phase 3,Phase 3
45 Antirheumatic Agents Phase 2, Phase 3,Phase 3
46 Peripheral Nervous System Agents Phase 2, Phase 3,Phase 3
47 Analgesics Phase 2, Phase 3,Phase 3
48 Antipyretics Phase 2, Phase 3,Phase 3
49 Fibrinolytic Agents Phase 2, Phase 3,Phase 3
50 Anti-Inflammatory Agents Phase 2, Phase 3,Phase 3

Interventional clinical trials:

(show all 46)
# Name Status NCT ID Phase Drugs
1 Efficacy of Three Antibiotic Protocols for Aggressive Periodontitis Treatment Unknown status NCT02839421 Phase 4 Scaling and Root Planing combined with moxifloxacin
2 Adjunctive Systemic Administration of Moxifloxacin in the Treatment of Aggressive Periodontitis Completed NCT02125812 Phase 4
3 Evaluation of Efficacy of Full-mouth Disinfection in Generalized Aggressive Periodontitis Patients Completed NCT02466646 Phase 4 Klorhex® Gel, rinse and sprey
4 Triclosan as Adjunctive Therapy in the Plaque Control in Children From Generalized Aggressive Periodontitis Families. Completed NCT03642353 Phase 4 Triclosan;Placebo
5 Treatment of Aggressive Periodontitis With Repeated Adjunctive Antimicrobial Photodynamic Therapy Completed NCT02049008 Phase 4
6 Host Modulatory Effects of β-glucan on Localized Aggressive Periodontitis Completed NCT02402296 Phase 4 β-1,3/1,6-D-glucan
7 Alternative Antibiotic Regime in the Treatment of GAgP Completed NCT02223702 Phase 4 Amoxicillin;Metronidazole;Moxifloxacin
8 Enamel Matrix Proteins in the Treatment of Intrabony Defects in Patients With Aggressive and Chronic Periodontitis Completed NCT03025204 Phase 4
9 Two Different Antibiotic Agents to Treat Generalized Aggressive Periodontitis Completed NCT02969928 Phase 2, Phase 3 Clarithromycin;Amoxicillin;Metronidazole
10 Periodontal Debridement Associated With Systemic Antibiotics and Single/Repeated PDT to Treat Aggressive Periodontitis Completed NCT03132714 Phase 2, Phase 3 Amoxicillin 500mg;Metronidazole 400mg;Clarithromycin 500mg
11 Omega-3 Plus Low-dose Aspirin Daily Supplementation in Non-surgical Therapy to Treat Aggressive Periodontitis Recruiting NCT03093246 Phase 2, Phase 3 Aspirin
12 Omega-3 Fatty Acids Plus Low-dose Aspirin Daily Supplementation in Surgical Therapy to Treat Aggressive Periodontitis Recruiting NCT03093207 Phase 2, Phase 3 Aspirin
13 Doxycycline in the Treatment of Aggressive Periodontitis Completed NCT03727620 Phase 1, Phase 2 amoxicillin plus metronidazole;Doxycycline
14 The Affect of Orthodontic Treatment on the Periodontal Status of Patients With Aggressive Periodontitis Unknown status NCT01510808
15 Polymorphonuclear Cells' Sensitivity to Aggregatibacter Actinomycetemcomitans Bacteria in Patients With Aggressive Periodontitis Unknown status NCT02010307 Not Applicable
16 Chronic Presence of Epstein Barr Virus in Epithelial Cells From Gingiva is Associated With Periodontitis Unknown status NCT01246596 Not Applicable
17 B Cell Functions in Periodontitis Unknown status NCT02833285
18 Immunolocalization of 1,25,Dihydroxyvitamin D3 in Aggressive Periodontitis Patients Completed NCT02282800
19 Gene Expression Profiles in Generalized Aggressive Periodontitis: A Gene Network-based Microarray Analysis Completed NCT02327533
20 Effects of Smoking on Non-surgical Periodontal Therapy in Generalized Aggressive Periodontitis Completed NCT03512938 Not Applicable
21 Effects Of Adjunctive Photodynamic Therapy To Non-Surgical Periodontal Treatment In Patients With Generalized Aggressive Periodontitis Completed NCT03412331 Not Applicable
22 Gingival Crevicular Fluid Levels Of Monocyte Chemoattractant Protein-1 Completed NCT02927704
23 Frequency Of MCP-1 And CCR2 Gene Polymorphisms And Its Effect On Gene Expression In Patients With AgP Completed NCT02817568
24 Effects of Er,Cr:YSGG, Diode Lasers on GCF Cytokines Levels Completed NCT03034824 Not Applicable
25 Clarithromycin as Adjuvant to Periodontal Debridement Completed NCT02829983 Not Applicable Clarithromycin;Placebo
26 Smoking Influence on Apoptosis in Periodontitis Completed NCT02111005
27 Nonsurgical Periodontal Treatment Associated or Not With Systemic Antibiotics and Photodynamic Therapy Completed NCT03142776 Not Applicable systemic clarithromycin
28 Tissue Alterations in Aggressive and Chronic Periodontitis Completed NCT03625414
29 Effect of Surgical Therapy on RANKL/OPG (Osteoprotegerin) System Completed NCT02190773
30 Estimation of Pentrexin-3 Levels in GCF and Saliva of Patients With Periodontal Disease Completed NCT03128502
31 Clinical, Immunological and Microbiological Evaluation of Experimental Gingivitis and Peri-implant Mucositis Completed NCT03713567 Not Applicable
32 Nitro-oxidative Stress in Periodontitis Completed NCT02127203
33 TNF-α/HIF-1α/VEGF Pathway in Periodontal Diseases Completed NCT03558906
34 Active Matrix Metalloproteinase-8 (aMMP-8) Chair-side Test in Different Periodontal Disease Completed NCT03527901
35 The Importance of Periostin in Periodontal Health and Disease Completed NCT01180920
36 Gingival Bleeding and Von Willebrand Disease Typ 2 and 3 Completed NCT03078595
37 Perforated Collagen Membrane With Nanohydroxyapatite for Intrabony Defects Completed NCT03399279 Not Applicable
38 Immediate Implant Placement in Aggressive Periodontitis Recruiting NCT03218228 Not Applicable
39 Subgingival Microbiome Following Mechanical Treatment and it's Effect on Peri-implant Sub-mucosa in Aggressive Periodontitis Patients Recruiting NCT03090282
40 EMD for Treatment of Proximal Class-II Furcation Involvements Recruiting NCT03320135 Not Applicable
41 Mechanisms and Treatment Response of Aggressive Periodontitis in Children Active, not recruiting NCT01330719 Not Applicable
42 Comparison Between Surgical Access and Repeated Applications of APDT Active, not recruiting NCT03140059 Not Applicable
43 Interaction Between Immune Cells and Bacteria Associated With Periodontitis Active, not recruiting NCT03225950
44 Long-term Results After Systematic Periodontal Therapy Enrolling by invitation NCT03048045
45 Clinical and Radiographic Evaluation of Guided Tissue Regeneration With Radiation-sterilized Allogenic Bone Grafts or Xenogenic Grafts for the Treatment of Intrabony Defects in Aggressive Periodontitis Not yet recruiting NCT03340012 Not Applicable
46 Analysis of Osteoimmune Interactions Linking Inflammation and Bone Destruction in Aggressive Periodontitis Terminated NCT01993368 Not Applicable

Search NIH Clinical Center for Aggressive Periodontitis

Cochrane evidence based reviews: aggressive periodontitis

Genetic Tests for Aggressive Periodontitis

Anatomical Context for Aggressive Periodontitis

MalaCards organs/tissues related to Aggressive Periodontitis:

41
Bone, Neutrophil, Monocytes, Lung, Skin, Heart, Eye

Publications for Aggressive Periodontitis

Articles related to Aggressive Periodontitis:

(show top 50) (show all 723)
# Title Authors Year
1
Discrepancy of Clinical Parameters between the First and Second Molars Can Help to Differentiate Subjects with Aggressive Periodontitis from Chronic Periodontitis: a Cross-sectional Study Based on a Large Chinese Population. ( 29808177 )
2018
2
Diagnosis of aggressive periodontitis: A dilemma? ( 29363676 )
2018
3
Consanguinity increases the risk for aggressive periodontitis. ( 29947052 )
2018
4
Feasibility of using allograft bone with resorbable collagen membrane for alveolar ridge vertical defect augmentation for dental implant placement in Patient with Aggressive Periodontitis: A case report. ( 29942111 )
2018
5
The Subgingival Microbiome of Periodontal Pockets With Different Probing Depths in Chronic and Aggressive Periodontitis: A Pilot Study. ( 29765908 )
2018
6
12 years' preservation of maxillary permanent incisors with cervical root fractures adjacent to aggressive periodontitis: Report of a case. ( 29786703 )
2018
7
Assessment of Lipid Peroxidation Levels and Total Antioxidant Status in Chronic and Aggressive Periodontitis Patients: An in vivo Study. ( 29603700 )
2018
8
Analysis of metabolic profiles of generalized aggressive periodontitis. ( 29974463 )
2018
9
Management of localized aggressive periodontitis: A 30-year follow-up. ( 29930995 )
2018
10
Definition of aggressive periodontitis in periodontal research. A systematic review. ( 29226356 )
2018
11
Radiographic morphology of intrabony defects in the first molars of patients with localized aggressive periodontitis: Comparison with health and chronic periodontitis. ( 29660823 )
2018
12
Classification and diagnosis of aggressive periodontitis. ( 29926487 )
2018
13
Interleukin-17 and interleukin-23 levels in gingival crevicular fluid of patients with chronic and aggressive periodontitis. ( 29736149 )
2018
14
A novel U-shaped relationship between BMI and risk of generalized aggressive periodontitis in Chinese: A cross-sectional study. ( 29944736 )
2018
15
Clinical performance of non-surgical periodontal therapy in a large Chinese population with generalized aggressive periodontitis. ( 29974483 )
2018
16
Association between circulating levels of heat-shock protein 27 and aggressive periodontitis. ( 29766408 )
2018
17
Localization and density of Porphyromonas gingivalis and Tannerella forsythia in gingival and subgingival granulation tissues affected by chronic or aggressive periodontitis. ( 29934515 )
2018
18
Localised aggressive periodontitis in a 3-year-old-boy. ( 29332208 )
2018
19
Impact of aggressive periodontitis and chronic periodontitis on oral health-related quality of life. ( 29451591 )
2018
20
Classification and diagnosis of aggressive periodontitis. ( 29926947 )
2018
21
Treatment of intrabony defects with modified perforated membranes in aggressive periodontitis: a 12-month randomized controlled trial. ( 29411112 )
2018
22
Single Sitting Surgical Treatment of Generalized Aggressive Periodontitis Using GTR Technique and Immediate Implant Placement with 10-Year Follow-Up. ( 29607223 )
2018
23
Outcomes After 25 Years of Periodontal Treatment and Maintenance of a Patient Affected by Generalized Severe Aggressive Periodontitis. ( 29641623 )
2018
24
mRNA expression OF IFN-I>s in the gingival tissue of chronic and aggressive periodontitis patients: A polymerase chain reaction study. ( 29717481 )
2018
25
CCR5I932 (rs333) polymorphism is associated with decreased risk of chronic and aggressive periodontitis: A case-control analysis based in disease resistance and susceptibility phenotypes. ( 28969941 )
2018
26
Association analysis of FAS-670A/G and FASL-844C/T polymorphisms with risk of generalized aggressive periodontitis disease. ( 29541461 )
2018
27
Human herpesviruses may be associated with the development of aggressive periodontitis. ( 29548690 )
2018
28
Aggressive periodontitis presents a higher degree of bilateral symmetry in comparison with chronic periodontitis. ( 29576581 )
2018
29
Visfatin expression in gingival tissues of chronic periodontitis and aggressive periodontitis patients: An immunohistochemical analysis. ( 29576773 )
2018
30
Orthodontic treatment in patients with aggressive periodontitis. ( 29602347 )
2018
31
Validation of reported GLT6D1 (rs1537415), IL10 (rs6667202), and ANRIL (rs1333048) single nucleotide polymorphisms for aggressive periodontitis in a Brazilian population. ( 30030838 )
2018
32
Superoxide Dismutase, Uric Acid, Total Antioxidant Status, and Lipid Peroxidation Assay in Chronic and Aggressive Periodontitis Patients. ( 30066694 )
2018
33
Efficacy of adjunctive photodynamic therapy in the treatment of generalized aggressive periodontitis: A randomized controlled clinical trial. ( 30095173 )
2018
34
Gingival Recession and Localized Aggressive Periodontitis Among HIV-Infected Children and Adolescents Receiving Antiretroviral Therapy. ( 30096098 )
2018
35
Vitamin D deficiency in patients with aggressive periodontitis. ( 30169905 )
2018
36
Efficacy of adjunctive low-level laser therapy in the treatment of aggressive periodontitis: A systematic review. ( 30198204 )
2018
37
A comparative study of synbiotic as an add-on therapy to standard treatment in patients with aggressive periodontitis. ( 30210194 )
2018
38
Oral health-related quality of life and standard of treatment in aggressive periodontitis patients more than 5 years after therapy. ( 30216484 )
2018
39
Evaluation of the local effect of nonsurgical periodontal treatment with and without systemic antibiotic and photodynamic therapy in generalized aggressive periodontitis. A randomized clinical trial. ( 30227258 )
2018
40
Identification of genetic risk factors of aggressive periodontitis using genomewide association studies in association with those of chronic periodontitis. ( 30303256 )
2018
41
Early postoperative healing following guided tissue regeneration in aggressive periodontitis patients. ( 30328307 )
2018
42
Assessment of microRNA-146a in generalized aggressive periodontitis and its association with disease severity. ( 30328616 )
2018
43
The role of three interleukin 10 gene polymorphisms (- 1082 A > G, - 819 C > T, - 592 A > C) in the risk of chronic and aggressive periodontitis: a meta-analysis and trial sequential analysis. ( 30348144 )
2018
44
Comparison of miRNA expression profiles in individuals with chronic or aggressive periodontitis. ( 30350903 )
2018
45
Functional Polymorphisms of CTLA4 Associated with Aggressive Periodontitis in the Chinese Han Population. ( 30355938 )
2018
46
Treatment of intrabony defects with modified perforated membranes in aggressive periodontitis: subtraction radiography outcomes, prognostic variables, and patient morbidity. ( 30374832 )
2018
47
Multidisciplinary Clinical Management of a Localized Aggressive Periodontitis diagnosed in a Child with Glanzmann's Thrombasthenia. ( 30397380 )
2018
48
Expression of growth mediators in the gingival crevicular fluid of patients with aggressive periodontitis undergoing periodontal surgery. ( 30498980 )
2018
49
Effect of periodontal treatment on Aggregatibacter actinomycetemcomitans (Aa) colonization and serum IgG levels against Aa serotypes and Omp29 of aggressive periodontitis patients. ( 30506613 )
2018
50
Association of NOD2 Mutations with Aggressive Periodontitis. ( 28682159 )
2017

Variations for Aggressive Periodontitis

Expression for Aggressive Periodontitis

Search GEO for disease gene expression data for Aggressive Periodontitis.

Pathways for Aggressive Periodontitis

Pathways related to Aggressive Periodontitis according to GeneCards Suite gene sharing:

(show top 50) (show all 74)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.99 CTSC CXCL8 FCGR2A FPR1 IL10 IL1A
2
Show member pathways
13.74 CXCL8 IL10 IL1A IL1B IL1RN IL4
3
Show member pathways
13.48 CXCL8 IL10 IL1A IL1B IL4 IL6
4
Show member pathways
13.42 CXCL8 FPR1 IL10 IL1A IL1B IL1RN
5
Show member pathways
13.37 CXCL8 IL10 IL1A IL1B IL4 IL6
6
Show member pathways
13.05 CXCL8 IL10 IL1B IL6 TLR4 TNF
7
Show member pathways
12.97 CXCL8 IL10 IL1A IL1B IL4 IL6
8
Show member pathways
12.91 CXCL8 IL1A IL1B IL4 IL6 TLR4
9
Show member pathways
12.8 CXCL8 IL1B IL6 TLR4 TNF
10
Show member pathways
12.75 IL1A IL1B IL6 TLR4 TNF
11
Show member pathways
12.71 IL10 IL1A IL1B IL4 IL6 TLR4
12
Show member pathways
12.67 IL1A IL1B TLR4 TNF TNFSF11
13 12.67 IL10 IL1B IL1RN IL4 TNF TNFSF11
14
Show member pathways
12.55 IL10 IL1A IL1B IL4 IL6 TNF
15
Show member pathways
12.45 CXCL8 IL1B IL4 IL6 MMP1 TNF
16
Show member pathways
12.44 CXCL8 IL1A IL1B IL6 TLR4 TNF
17
Show member pathways
12.38 IL1B IL4 IL6 TNF
18
Show member pathways
12.38 CXCL8 IL10 IL1A IL1B IL4 IL6
19
Show member pathways
12.37 CXCL8 IL1A IL6 TLR4 TNF
20
Show member pathways
12.36 FCGR2A IL10 IL1A IL1B IL4 TLR4
21
Show member pathways
12.34 CXCL8 IL1A IL1B IL1RN IL6 TNF
22 12.33 FCGR2A IL10 IL1A IL1B IL6 TLR4
23
Show member pathways
12.3 CXCL8 IL1B IL4 IL6 TLR4 TNF
24
Show member pathways
12.29 CXCL8 IL1A IL1B MMP1 MMP8 TLR4
25 12.28 CXCL8 IL10 IL1A IL1B IL1RN IL6
26
Show member pathways
12.27 IL10 IL1B IL6 TNF
27
Show member pathways
12.27 IL1A IL1B TLR4 TNF
28 12.24 IL6 MMP1 TLR4 TNF
29
Show member pathways
12.19 IL10 IL1B IL6 TLR4 TNF
30
Show member pathways
12.18 CXCL8 IL10 IL1A IL1B IL4 IL6
31 12.18 FCGR2A IL1A IL1B TNF TNFSF11
32
Show member pathways
12.16 FCGR2A IL1B IL4 IL6 TLR4 TNF
33 12.13 FCGR2A IL10 IL4 IL6 TNF
34 12.04 CXCL8 IL1A IL1B IL6
35 12.04 CXCL8 IL1A IL1B IL6 TNF
36 12.03 IL1A IL1B IL4 IL6 TNF
37 12.02 CXCL8 IL1B TLR4 TNF TNFSF11
38 12.02 CXCL8 IL10 IL1B IL6 TLR4 TNF
39 11.97 CXCL8 IL1A IL1B IL6 TLR4
40 11.96 IL1B IL6 TNF
41 11.94 CXCL8 FCGR2A IL1A IL1B IL4 IL6
42
Show member pathways
11.92 MMP1 MMP8 TNF
43 11.92 CXCL8 IL4 IL6 MMP1
44 11.9 IL10 IL1B IL4 TNF
45
Show member pathways
11.89 CXCL8 IL6 TLR4
46 11.87 IL10 IL1B IL6 TNF
47 11.83 CXCL8 IL10 IL1A IL1B IL6 TLR4
48 11.81 CXCL8 IL10 IL1A IL1B IL4 IL6
49
Show member pathways
11.8 CXCL8 IL4 TNF
50 11.8 CXCL8 IL1B IL4 IL6 TNF

GO Terms for Aggressive Periodontitis

Cellular components related to Aggressive Periodontitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.73 CTSC CXCL8 IL10 IL1A IL1B IL1RN
2 extracellular region GO:0005576 9.44 CTSC CXCL8 IL10 IL1A IL1B IL1RN

Biological processes related to Aggressive Periodontitis according to GeneCards Suite gene sharing:

(show top 50) (show all 65)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 9.99 IL1B IL1RN LTF TLR4 TNF TNFSF11
2 regulation of signaling receptor activity GO:0010469 9.97 CXCL8 IL10 IL1A IL1B IL1RN IL4
3 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.95 IL1B IL6 LTF TLR4 TNF TNFSF11
4 cellular response to lipopolysaccharide GO:0071222 9.95 CXCL8 IL10 IL1B IL1RN IL6 TLR4
5 activation of MAPK activity GO:0000187 9.93 FPR1 IL1B TLR4 TNF
6 positive regulation of DNA-binding transcription factor activity GO:0051091 9.93 IL10 IL1B IL6 TNF TNFSF11
7 positive regulation of JNK cascade GO:0046330 9.91 IL1B IL1RN MMP8 TLR4 TNF TNFSF11
8 response to organic substance GO:0010033 9.9 CTSC IL10 TNF
9 defense response to Gram-negative bacterium GO:0050829 9.9 IL6 LTF TLR4
10 neutrophil chemotaxis GO:0030593 9.89 CXCL8 IL1B IL1RN
11 response to glucocorticoid GO:0051384 9.89 IL10 IL1B IL1RN IL6 TNF
12 positive regulation of T cell proliferation GO:0042102 9.87 IL1B IL4 IL6
13 humoral immune response GO:0006959 9.87 IL6 LTF TNF
14 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.87 IL1B MMP8 TLR4 TNF
15 interleukin-1-mediated signaling pathway GO:0070498 9.86 IL1A IL1B IL1RN
16 positive regulation of nitric oxide biosynthetic process GO:0045429 9.86 IL1B MMP8 TLR4 TNF
17 positive regulation of interferon-gamma production GO:0032729 9.85 IL1B TLR4 TNF
18 positive regulation of JUN kinase activity GO:0043507 9.83 IL1B IL1RN TNF
19 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001240 9.81 IL1A IL1B TNF
20 lipopolysaccharide-mediated signaling pathway GO:0031663 9.81 IL1B TLR4 TNF
21 inflammatory response GO:0006954 9.81 CXCL8 FPR1 IL10 IL1A IL1B IL1RN
22 negative regulation of interleukin-6 production GO:0032715 9.8 IL10 TLR4 TNF
23 positive regulation of cytokine secretion GO:0050715 9.79 IL10 IL1A TNF
24 positive regulation of interleukin-8 production GO:0032757 9.79 IL1B TLR4 TNF
25 negative regulation of neurogenesis GO:0050768 9.78 IL1B IL6 TNF
26 positive regulation of chemokine production GO:0032722 9.77 IL6 TLR4 TNF
27 positive regulation of glial cell proliferation GO:0060252 9.76 IL1B IL6 TNF
28 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.75 IL10 IL1B TNF
29 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.74 IL1B TNF
30 negative regulation of growth of symbiont in host GO:0044130 9.73 IL10 TNF
31 regulation of osteoclast differentiation GO:0045670 9.73 TNF TNFSF11
32 positive regulation of reactive oxygen species biosynthetic process GO:1903428 9.73 MMP8 TLR4
33 positive regulation of interleukin-2 biosynthetic process GO:0045086 9.73 IL1A IL1B
34 positive regulation of interleukin-6 production GO:0032755 9.73 IL1B IL1RN IL6 MMP8 TLR4 TNF
35 response to molecule of bacterial origin GO:0002237 9.72 CXCL8 IL10
36 negative regulation of heterotypic cell-cell adhesion GO:0034115 9.72 IL10 IL1RN
37 positive regulation of MHC class II biosynthetic process GO:0045348 9.72 IL10 IL4 TLR4
38 positive regulation of interleukin-8 biosynthetic process GO:0045416 9.71 TLR4 TNF
39 negative regulation of lipid storage GO:0010888 9.71 IL6 TNF
40 endothelial cell apoptotic process GO:0072577 9.71 IL10 TNF
41 positive regulation of chemokine biosynthetic process GO:0045080 9.71 IL1B TNF
42 ectopic germ cell programmed cell death GO:0035234 9.7 IL1A IL1B
43 negative regulation of glutamate secretion GO:0014050 9.7 IL1B IL1RN
44 regulation of establishment of endothelial barrier GO:1903140 9.7 IL1B TNF
45 chronic inflammatory response to antigenic stimulus GO:0002439 9.7 IL1B IL1RN TNF
46 immune response GO:0006955 9.7 CTSC CXCL8 IL10 IL1A IL1B IL1RN
47 negative regulation of cytokine secretion involved in immune response GO:0002740 9.68 IL10 TNF
48 negative regulation of interleukin-1-mediated signaling pathway GO:2000660 9.68 IL1RN IL6
49 positive regulation of fever generation GO:0031622 9.68 IL1B TNF
50 regulation of isotype switching GO:0045191 9.67 IL10 IL4

Molecular functions related to Aggressive Periodontitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 serine-type endopeptidase activity GO:0004252 9.46 CTSC LTF MMP1 MMP8
2 cytokine activity GO:0005125 9.28 CXCL8 IL10 IL1A IL1B IL1RN IL4
3 interleukin-1 receptor binding GO:0005149 9.13 IL1A IL1B IL1RN

Sources for Aggressive Periodontitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
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54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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