MCID: AGG001
MIFTS: 54

Aggressive Periodontitis

Categories: Oral diseases, Genetic diseases

Aliases & Classifications for Aggressive Periodontitis

MalaCards integrated aliases for Aggressive Periodontitis:

Name: Aggressive Periodontitis 12 44 15
Periodontitis, Juvenile 73
Juvenile Periodontitis 12

Classifications:



External Ids:

Disease Ontology 12 DOID:1474
ICD10 33 K05.2
MeSH 44 D010520
UMLS 73 C0031106

Summaries for Aggressive Periodontitis

Disease Ontology : 12 A periodontitis that is characterized by rapid attachment loss and bone destruction in the presence of little local factors such as dental plaque and dental calculus resulting in inflammation and a loss of periodontium.

MalaCards based summary : Aggressive Periodontitis, also known as periodontitis, juvenile, is related to periodontitis, aggressive, 1 and spondylitis. An important gene associated with Aggressive Periodontitis is PDON2 (Periodontitis, Localized Aggressive), and among its related pathways/superpathways are Innate Immune System and PEDF Induced Signaling. The drugs Amoxicillin and Estradiol have been mentioned in the context of this disorder. Affiliated tissues include bone, neutrophil and monocytes, and related phenotypes are hematopoietic system and homeostasis/metabolism

Wikipedia : 76 Aggressive periodontitis describes a type of periodontal disease and includes two of the seven... more...

Related Diseases for Aggressive Periodontitis

Diseases in the Aggressive Periodontitis family:

Periodontitis, Aggressive, 1 Periodontitis, Aggressive, 2

Diseases related to Aggressive Periodontitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 318)
# Related Disease Score Top Affiliating Genes
1 periodontitis, aggressive, 1 32.2 CTSC FPR1 IL1A MMP8
2 spondylitis 30.3 IL1RN IL6 TNF
3 conjunctivitis 30.0 CXCL8 IL4 IL6
4 gingivitis 29.6 CXCL8 IL1A IL1B IL4 IL6 MMP8
5 periodontosis 29.5 CXCL8 TLR4 TNFSF11
6 diabetes mellitus 29.3 IL1A IL1B IL1RN IL6 TNF
7 arthritis 28.2 CXCL8 IL10 IL1A IL1B IL1RN IL6
8 rheumatoid arthritis 26.5 CXCL8 IL10 IL1A IL1B IL1RN IL4
9 periodontitis 25.7 CTSC CXCL8 FPR1 IL10 IL1A IL1B
10 periodontal disease 24.9 CTSC CXCL8 DEFB1 IL1A IL1B IL1RN
11 susceptibility to localized juvenile periodontitis 12.0
12 papillon-lefevre syndrome 11.3
13 punctate inner choroidopathy 11.0 IL10 TNF
14 chronic follicular conjunctivitis 10.9 IL1A IL1B
15 systemic onset juvenile idiopathic arthritis 10.9 IL1B TNF
16 scorpion envenomation 10.9 IL6 TNF
17 staphylococcal toxic shock syndrome 10.9 IL1B TNF
18 autoimmune myocarditis 10.9 IL1B TNF
19 leukomalacia 10.9 IL6 TNF
20 angioimmunoblastic lymphadenopathy with dysproteinemia 10.8 IL6 TNF
21 microscopic polyangiitis 10.8 IL10 TNF
22 multifocal choroiditis 10.8 IL10 TNF
23 irritant dermatitis 10.8 IL1A IL1B TNF
24 kashin-beck disease 10.8 IL1B TNF
25 vulvar vestibulitis syndrome 10.8 IL1B IL1RN TNF
26 cerebral artery occlusion 10.8 IL1B IL1RN TNF
27 meningococcemia 10.8 IL1A IL1B IL1RN
28 eye lymphoma 10.8 IL10 IL6
29 laryngitis 10.8 IL1B IL6 TNF
30 hyperlucent lung 10.8 IL10 IL4
31 multidrug-resistant tuberculosis 10.8 IL10 IL1A TNF
32 acute vascular insufficiency of intestine 10.8 IL1B IL6 TNF
33 poems syndrome 10.8 IL1B IL6 TNF
34 central nervous system vasculitis 10.7 IL1B IL6 TNF
35 endometritis 10.7 IL1B IL6 TNF
36 transient hypogammaglobulinemia 10.7 IL10 TNF
37 commensal bacterial infectious disease 10.7 IL1B IL6 TNF
38 extrapulmonary tuberculosis 10.7 IL10 IL1B IL1RN
39 critical limb ischemia 10.7 IL6 TNF
40 listeriosis 10.7 IL10 IL6 TNF
41 chikungunya 10.7 IL1B IL6 TNF
42 hydrarthrosis 10.7 IL1B IL1RN IL6
43 intermediate uveitis 10.7 IL10 IL6 TNF
44 hemorrhagic fever 10.7 IL10 IL6 TNF
45 hematopoietic stem cell transplantation 10.7 IL10 IL6 TNF
46 pericarditis 10.7 IL1B IL6 TNF
47 plasmodium vivax malaria 10.7 IL10 IL6 TNF
48 tropical endomyocardial fibrosis 10.7 IL10 IL4 TNF
49 intervertebral disc disease 10.7 IL1A IL1B IL6
50 hemorrhagic fever with renal syndrome 10.7 IL10 IL6 TNF

Graphical network of the top 20 diseases related to Aggressive Periodontitis:



Diseases related to Aggressive Periodontitis

Symptoms & Phenotypes for Aggressive Periodontitis

MGI Mouse Phenotypes related to Aggressive Periodontitis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.18 IL1A TLR4 IL1B CTSC IL1RN FCGR2A
2 homeostasis/metabolism MP:0005376 10.13 MMP8 IL1A TLR4 IL1B CTSC IL1RN
3 immune system MP:0005387 10.1 IL1A TLR4 IL1B CTSC IL1RN FCGR2A
4 integument MP:0010771 9.85 IL1A TLR4 IL1B CTSC IL1RN IL4
5 neoplasm MP:0002006 9.56 IL1A TLR4 IL1B IL6 IL10 MMP8
6 skeleton MP:0005390 9.32 TLR4 IL1B IL1RN FCGR2A FCGR3B IL4

Drugs & Therapeutics for Aggressive Periodontitis

Drugs for Aggressive Periodontitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 63)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Amoxicillin Approved, Vet_approved Phase 4,Phase 2,Phase 3,Not Applicable 26787-78-0 33613
2
Estradiol Approved, Investigational, Vet_approved Phase 4 50-28-2 5757
3 Estradiol valerate Approved, Investigational, Vet_approved Phase 4 979-32-8
4
Ethinyl Estradiol Approved Phase 4 57-63-6 5991
5
Metronidazole Approved Phase 4,Phase 2,Phase 3,Not Applicable 443-48-1 4173
6
Moxifloxacin Approved, Investigational Phase 4 354812-41-2, 151096-09-2 152946
7
Norgestimate Approved, Investigational Phase 4 35189-28-7 6540478
8
Polyestradiol phosphate Approved Phase 4 28014-46-2
9
Chlorhexidine Approved, Vet_approved Phase 4 55-56-1 9552079 2713
10 Anesthetics Phase 4
11 Anti-Bacterial Agents Phase 4,Phase 2,Phase 3,Not Applicable
12 Antibiotics, Antitubercular Phase 4,Phase 2,Phase 3,Not Applicable
13 Anti-Infective Agents Phase 4,Phase 2,Phase 3,Not Applicable
14 Antiparasitic Agents Phase 4,Phase 2,Phase 3
15 Antiprotozoal Agents Phase 4,Phase 2,Phase 3
16 Contraceptive Agents Phase 4
17 Contraceptives, Oral Phase 4
18 Contraceptives, Oral, Combined Phase 4
19 Estradiol 17 beta-cypionate Phase 4
20 Estradiol 3-benzoate Phase 4
21 Fluoroquinolones Phase 4
22 Norgestimate, ethinyl estradiol drug combination Phase 4
23 Nucleic Acid Synthesis Inhibitors Phase 4
24 Topoisomerase Inhibitors Phase 4
25 Chlorhexidine gluconate Phase 4
26 Anesthetics, Local Phase 4
27
Clarithromycin Approved Phase 2, Phase 3,Phase 3,Not Applicable 81103-11-9 84029
28
Aspirin Approved, Vet_approved Phase 2, Phase 3,Phase 3 50-78-2 2244
29 Cytochrome P-450 CYP3A Inhibitors Phase 2, Phase 3,Phase 3,Not Applicable
30 Cytochrome P-450 Enzyme Inhibitors Phase 2, Phase 3,Phase 3,Not Applicable
31 Analgesics Phase 2, Phase 3,Phase 3
32 Analgesics, Non-Narcotic Phase 2, Phase 3,Phase 3
33 Anti-Inflammatory Agents Phase 2, Phase 3,Phase 3
34 Anti-Inflammatory Agents, Non-Steroidal Phase 2, Phase 3,Phase 3
35 Antipyretics Phase 2, Phase 3,Phase 3
36 Antirheumatic Agents Phase 2, Phase 3,Phase 3
37 Cyclooxygenase Inhibitors Phase 2, Phase 3,Phase 3
38 Fibrinolytic Agents Phase 2, Phase 3,Phase 3
39 Peripheral Nervous System Agents Phase 2, Phase 3,Phase 3
40 Platelet Aggregation Inhibitors Phase 2, Phase 3,Phase 3
41 Omega 3 Fatty Acid Nutraceutical Phase 2, Phase 3,Phase 3
42
Nitric Oxide Approved 10102-43-9 145068 160954
43
Ergocalciferol Approved, Nutraceutical 50-14-6 5280793
44
Vitamin D Approved, Nutraceutical, Vet_approved 1406-16-2
45 Bone Density Conservation Agents
46 Dihydroxycholecalciferols
47 Ergocalciferols
48 Micronutrients
49 Trace Elements
50 Vitamins

Interventional clinical trials:

(show all 42)
# Name Status NCT ID Phase Drugs
1 Efficacy of Three Antibiotic Protocols for Aggressive Periodontitis Treatment Unknown status NCT02839421 Phase 4 Scaling and Root Planing combined with moxifloxacin
2 Adjunctive Systemic Administration of Moxifloxacin in the Treatment of Aggressive Periodontitis Completed NCT02125812 Phase 4
3 Evaluation of Efficacy of Full-mouth Disinfection in Generalized Aggressive Periodontitis Patients Completed NCT02466646 Phase 4 Klorhex® Gel, rinse and sprey
4 Treatment of Aggressive Periodontitis With Repeated Adjunctive Antimicrobial Photodynamic Therapy Completed NCT02049008 Phase 4
5 Host Modulatory Effects of β-glucan on Localized Aggressive Periodontitis Completed NCT02402296 Phase 4 β-1,3/1,6-D-glucan
6 Alternative Antibiotic Regime in the Treatment of GAgP Completed NCT02223702 Phase 4 Amoxicillin;Metronidazole;Moxifloxacin
7 Enamel Matrix Proteins in the Treatment of Intrabony Defects in Patients With Aggressive and Chronic Periodontitis Recruiting NCT03025204 Phase 4
8 Two Different Antibiotic Agents to Treat Generalized Aggressive Periodontitis Completed NCT02969928 Phase 2, Phase 3 Clarithromycin;Amoxicillin;Metronidazole
9 Periodontal Debridement Associated With Systemic Antibiotics and Single/Repeated PDT to Treat Aggressive Periodontitis Completed NCT03132714 Phase 2, Phase 3 Amoxicillin 500mg;Metronidazole 400mg;Clarithromycin 500mg
10 Omega-3 Plus Low-dose Aspirin Daily Supplementation in Non-surgical Therapy to Treat Aggressive Periodontitis Recruiting NCT03093246 Phase 2, Phase 3 Aspirin
11 Omega-3 Fatty Acids Plus Low-dose Aspirin Daily Supplementation in Surgical Therapy to Treat Aggressive Periodontitis Recruiting NCT03093207 Phase 2, Phase 3 Aspirin
12 The Affect of Orthodontic Treatment on the Periodontal Status of Patients With Aggressive Periodontitis Unknown status NCT01510808
13 Polymorphonuclear Cells' Sensitivity to Aggregatibacter Actinomycetemcomitans Bacteria in Patients With Aggressive Periodontitis Unknown status NCT02010307 Not Applicable
14 Chronic Presence of Epstein Barr Virus in Epithelial Cells From Gingiva is Associated With Periodontitis Unknown status NCT01246596 Not Applicable
15 Immunolocalization of 1,25,Dihydroxyvitamin D3 in Aggressive Periodontitis Patients Completed NCT02282800
16 Gene Expression Profiles in Generalized Aggressive Periodontitis: A Gene Network-based Microarray Analysis Completed NCT02327533
17 Effects of Smoking on Non-surgical Periodontal Therapy in Generalized Aggressive Periodontitis Completed NCT03512938 Not Applicable
18 Effects Of Adjunctive Photodynamic Therapy To Non-Surgical Periodontal Treatment In Patients With Generalized Aggressive Periodontitis Completed NCT03412331 Not Applicable
19 Gingival Crevicular Fluid Levels Of Monocyte Chemoattractant Protein-1 Completed NCT02927704
20 Frequency Of MCP-1 And CCR2 Gene Polymorphisms And Its Effect On Gene Expression In Patients With AgP Completed NCT02817568
21 Effects of Er,Cr:YSGG, Diode Lasers on GCF Cytokines Levels Completed NCT03034824 Not Applicable
22 Clarithromycin as Adjuvant to Periodontal Debridement Completed NCT02829983 Not Applicable Clarithromycin;Placebo
23 Smoking Influence on Apoptosis in Periodontitis Completed NCT02111005
24 Nonsurgical Periodontal Treatment Associated or Not With Systemic Antibiotics and Photodynamic Therapy Completed NCT03142776 Not Applicable systemic clarithromycin
25 Effect of Surgical Therapy on RANKL/OPG (Osteoprotegerin) System Completed NCT02190773
26 Estimation of Pentrexin-3 Levels in GCF and Saliva of Patients With Periodontal Disease Completed NCT03128502
27 Nitro-oxidative Stress in Periodontitis Completed NCT02127203
28 TNF-α/HIF-1α/VEGF Pathway in Periodontal Diseases Completed NCT03558906
29 Active Matrix Metalloproteinase-8 (aMMP-8) Chair-side Test in Different Periodontal Disease Completed NCT03527901
30 The Importance of Periostin in Periodontal Health and Disease Completed NCT01180920
31 Gingival Bleeding and Von Willebrand Disease Typ 2 and 3 Completed NCT03078595
32 Perforated Collagen Membrane With Nanohydroxyapatite for Intrabony Defects Completed NCT03399279 Not Applicable
33 Immediate Implant Placement in Aggressive Periodontitis Recruiting NCT03218228 Not Applicable
34 Subgingival Microbiome Following Mechanical Treatment and it's Effect on Peri-implant Sub-mucosa in Aggressive Periodontitis Patients Recruiting NCT03090282
35 Mechanisms and Treatment Response of Aggressive Periodontitis in Children Recruiting NCT01330719 Not Applicable
36 EMD for Treatment of Proximal Class-II Furcation Involvements Recruiting NCT03320135 Not Applicable
37 B Cell Functions in Periodontitis Recruiting NCT02833285
38 Interaction Between Immune Cells and Bacteria Associated With Periodontitis Recruiting NCT03225950
39 Comparison Between Surgical Access and Repeated Applications of APDT Active, not recruiting NCT03140059 Not Applicable
40 Long-term Results After Systematic Periodontal Therapy Enrolling by invitation NCT03048045
41 Clinical and Radiographic Evaluation of Guided Tissue Regeneration With Radiation-sterilized Allogenic Bone Grafts or Xenogenic Grafts for the Treatment of Intrabony Defects in Aggressive Periodontitis Not yet recruiting NCT03340012 Not Applicable
42 Analysis of Osteoimmune Interactions Linking Inflammation and Bone Destruction in Aggressive Periodontitis Terminated NCT01993368 Not Applicable

Search NIH Clinical Center for Aggressive Periodontitis

Cochrane evidence based reviews: aggressive periodontitis

Genetic Tests for Aggressive Periodontitis

Anatomical Context for Aggressive Periodontitis

MalaCards organs/tissues related to Aggressive Periodontitis:

41
Bone, Neutrophil, Monocytes, B Cells, Testes, Whole Blood, Colon

Publications for Aggressive Periodontitis

Articles related to Aggressive Periodontitis:

(show top 50) (show all 633)
# Title Authors Year
1
Discrepancy of Clinical Parameters between the First and Second Molars Can Help to Differentiate Subjects with Aggressive Periodontitis from Chronic Periodontitis: a Cross-sectional Study Based on a Large Chinese Population. ( 29808177 )
2018
2
Diagnosis of aggressive periodontitis: A dilemma? ( 29363676 )
2018
3
Consanguinity increases the risk for aggressive periodontitis. ( 29947052 )
2018
4
Feasibility of using allograft bone with resorbable collagen membrane for alveolar ridge vertical defect augmentation for dental implant placement in Patient with Aggressive Periodontitis: A case report. ( 29942111 )
2018
5
The Subgingival Microbiome of Periodontal Pockets With Different Probing Depths in Chronic and Aggressive Periodontitis: A Pilot Study. ( 29765908 )
2018
6
12 years' preservation of maxillary permanent incisors with cervical root fractures adjacent to aggressive periodontitis: Report of a case. ( 29786703 )
2018
7
Assessment of Lipid Peroxidation Levels and Total Antioxidant Status in Chronic and Aggressive Periodontitis Patients: An in vivo Study. ( 29603700 )
2018
8
Analysis of metabolic profiles of generalized aggressive periodontitis. ( 29974463 )
2018
9
Management of localized aggressive periodontitis: A 30-year follow-up. ( 29930995 )
2018
10
Definition of aggressive periodontitis in periodontal research. A systematic review. ( 29226356 )
2018
11
Radiographic morphology of intrabony defects in the first molars of patients with localized aggressive periodontitis: Comparison with health and chronic periodontitis. ( 29660823 )
2018
12
Classification and diagnosis of aggressive periodontitis. ( 29926487 )
2018
13
Interleukin-17 and interleukin-23 levels in gingival crevicular fluid of patients with chronic and aggressive periodontitis. ( 29736149 )
2018
14
A novel U-shaped relationship between BMI and risk of generalized aggressive periodontitis in Chinese: A cross-sectional study. ( 29944736 )
2018
15
Clinical performance of non-surgical periodontal therapy in a large Chinese population with generalized aggressive periodontitis. ( 29974483 )
2018
16
Association between circulating levels of heat-shock protein 27 and aggressive periodontitis. ( 29766408 )
2018
17
Localization and density of Porphyromonas gingivalis and Tannerella forsythia in gingival and subgingival granulation tissues affected by chronic or aggressive periodontitis. ( 29934515 )
2018
18
Localised aggressive periodontitis in a 3-year-old-boy. ( 29332208 )
2018
19
Impact of aggressive periodontitis and chronic periodontitis on oral health-related quality of life. ( 29451591 )
2018
20
Classification and diagnosis of aggressive periodontitis. ( 29926947 )
2018
21
Treatment of intrabony defects with modified perforated membranes in aggressive periodontitis: a 12-month randomized controlled trial. ( 29411112 )
2018
22
Single Sitting Surgical Treatment of Generalized Aggressive Periodontitis Using GTR Technique and Immediate Implant Placement with 10-Year Follow-Up. ( 29607223 )
2018
23
Outcomes After 25 Years of Periodontal Treatment and Maintenance of a Patient Affected by Generalized Severe Aggressive Periodontitis. ( 29641623 )
2018
24
mRNA expression OF IFN-I>s in the gingival tissue of chronic and aggressive periodontitis patients: A polymerase chain reaction study. ( 29717481 )
2018
25
Dental treatment of a rare case of pyoderma gangrenosum with aggressive periodontal disease. ( 29945713 )
2018
26
CCR5I932 (rs333) polymorphism is associated with decreased risk of chronic and aggressive periodontitis: A case-control analysis based in disease resistance and susceptibility phenotypes. ( 28969941 )
2018
27
Association of NOD2 Mutations with Aggressive Periodontitis. ( 28682159 )
2017
28
Moderate- to long-term therapeutic outcomes of treated aggressive periodontitis patients without regular supportive care. ( 29105779 )
2017
29
IL-6 and IL-10 gene polymorphisms in patients with aggressive periodontitis: effects on GCF, serum and clinic parameters. ( 28099578 )
2017
30
Aggressive periodontitis: The unsolved mystery. ( 28133644 )
2017
31
Comparing the efficiency of Er,Cr:YSGG laser and diode laser on human I^-defensin-1 and IL-1I^ levels during the treatment of generalized aggressive periodontitis and chronic periodontitis. ( 28557642 )
2017
32
Adjunctive Effect of Autologous Platelet-Rich Fibrin in the Treatment of Intrabony Defects in Localized Aggressive Periodontitis Patients: A Randomized Controlled Split-Mouth Clinical Trial. ( 29023611 )
2017
33
Herpesviruses in etiopathogenesis of aggressive periodontitis: A meta-analysis based on case-control studies. ( 29036216 )
2017
34
Effect of scaling & root planing on the activity of ALP in GCF & serum of patients with gingivitis, chronic and aggressive periodontitis: A comparative study. ( 28706787 )
2017
35
Disease Staging Index for Aggressive Periodontitis. ( 28831460 )
2017
36
Salivary and Serum Markers Related to Innate Immunity in Generalized Aggressive Periodontitis. ( 28753101 )
2017
37
Dimorphic anemia and mental depression as a result of systemic manifestations of generalized aggressive periodontitis: A pioneer case report. ( 29491590 )
2017
38
Towards the targeted management of aggressive periodontitis. ( 28571797 )
2017
39
Biomarker levels in gingival crevicular fluid of generalized aggressive periodontitis patients after non-surgical periodontal treatment. ( 28918557 )
2017
40
Diagnosis and Management of Chronic and Aggressive Periodontitis Part 1: Periodontal Assessment and Diagnosis. ( 29172354 )
2017
41
Transcriptome of Healthy Gingival Tissue from Edentulous Sites in Patients with a History of Aggressive Periodontitis. ( 28844188 )
2017
42
Cytokine profile in gingival crevicular fluid and plasma of patients with aggressive periodontitis. ( 28868949 )
2017
43
More than two-thirds of patients with localized aggressive periodontitis gained more than 2 millimeters of clinical attachment level after 4 years of maintenance treatment. ( 28666521 )
2017
44
Putative periodontopathic bacteria and herpes viruses interactions in the subgingival plaque of patients with aggressive periodontitis and healthy controls. ( 29744199 )
2017
45
The Effect of Nonsurgical Periodontal Therapy on the Level of Human Neutrophil Peptides 1-3 in Patients with Aggressive Periodontitis. ( 28944351 )
2017
46
Clinical Characteristics of Localized Aggressive Periodontitis in Primary Dentition. ( 29087795 )
2017
47
Radiographic Description of the Distribution of Aggressive Periodontitis in Primary Teeth. ( 29087797 )
2017
48
Aggregatibacter actinomycetemcomitans in African Americans with Localized Aggressive Periodontitis. ( 28879247 )
2017
49
Local and Plasma Biomarker Profiles in Localized Aggressive Periodontitis. ( 28879248 )
2017
50
Shift in the Subgingival Microbiome following Scaling and Root Planing in Generalized Aggressive Periodontitis. ( 29266363 )
2017

Variations for Aggressive Periodontitis

Expression for Aggressive Periodontitis

Search GEO for disease gene expression data for Aggressive Periodontitis.

Pathways for Aggressive Periodontitis

Pathways related to Aggressive Periodontitis according to GeneCards Suite gene sharing:

(show top 50) (show all 68)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.99 CTSC CXCL8 DEFB1 FCGR2A FCGR3B FPR1
2
Show member pathways
13.74 CXCL8 IL10 IL1A IL1B IL1RN IL4
3
Show member pathways
13.51 CXCL8 IL10 IL1A IL1B IL4 IL6
4
Show member pathways
13.47 CXCL8 IL10 IL1A IL1B IL4 IL6
5
Show member pathways
13.43 CXCL8 FPR1 IL10 IL1A IL1B IL1RN
6
Show member pathways
13.37 CXCL8 IL10 IL1A IL1B IL4 IL6
7
Show member pathways
13.04 CXCL8 IL10 IL1B IL6 TLR4 TNF
8
Show member pathways
12.96 CXCL8 IL10 IL1A IL1B IL4 IL6
9
Show member pathways
12.89 CXCL8 IL1A IL1B IL4 IL6 TLR4
10
Show member pathways
12.81 IL1A IL1B IL4 TLR4 TNF
11
Show member pathways
12.79 CXCL8 IL1B IL6 TLR4 TNF
12
Show member pathways
12.74 IL1A IL1B IL6 TLR4 TNF
13
Show member pathways
12.73 CXCL8 IL10 IL1A IL1B IL4 IL6
14 12.65 IL10 IL1B IL1RN IL4 TNF TNFSF11
15
Show member pathways
12.6 IL1A IL1B TLR4 TNF TNFSF11
16
Show member pathways
12.54 IL10 IL1A IL1B IL4 IL6 TNF
17
Show member pathways
12.52 IL10 IL1A IL1B IL4 IL6 TLR4
18
Show member pathways
12.42 CXCL8 IL1B IL4 IL6 TNF
19
Show member pathways
12.38 CXCL8 IL1A IL1B IL6 TLR4 TNF
20
Show member pathways
12.36 IL1B IL4 IL6 TNF
21
Show member pathways
12.36 CXCL8 IL1A IL6 TLR4 TNF
22
Show member pathways
12.35 IL10 IL1B IL6 TLR4 TNF
23
Show member pathways
12.33 CXCL8 IL1A IL1B IL1RN IL6 TNF
24
Show member pathways
12.31 FCGR2A FCGR3B IL10 IL1A IL1B IL4
25
Show member pathways
12.29 CXCL8 IL1B IL4 IL6 TLR4 TNF
26 12.27 CXCL8 IL10 IL1A IL1B IL1RN IL6
27
Show member pathways
12.26 IL10 IL1B IL6 TNF
28 12.26 FCGR2A FCGR3B IL10 IL1A IL1B IL6
29
Show member pathways
12.25 IL1A IL1B TLR4 TNF
30
Show member pathways
12.17 CXCL8 IL10 IL1A IL1B IL4 IL6
31 12.13 FCGR2A FCGR3B IL1A IL1B TNF TNFSF11
32 12.11 FCGR2A IL10 IL4 IL6 TNF
33 12.08 CXCL8 IL10 IL1A IL1B IL4 IL6
34 12.03 CXCL8 IL1A IL1B IL6
35 12.03 CXCL8 IL1A IL1B IL6 TNF
36 12.02 IL1A IL1B IL4 IL6 TNF
37 12 CXCL8 IL1B TLR4 TNF TNFSF11
38 11.98 CXCL8 IL10 IL1B IL6 TLR4 TNF
39 11.96 CXCL8 IL1A IL1B IL6 TLR4
40 11.95 IL1B IL6 TNF
41 11.89 IL10 IL1B IL4 TNF
42
Show member pathways
11.88 CXCL8 IL6 TLR4
43 11.87 CXCL8 IL1A IL1B IL6 TLR4 TNF
44 11.86 IL10 IL1B IL6 TNF
45 11.84 FCGR2A FCGR3B TLR4
46 11.82 CXCL8 IL4 IL6
47
Show member pathways
11.79 CXCL8 IL4 TNF
48 11.78 CXCL8 IL1B IL4 IL6 TNF
49
Show member pathways
11.77 CXCL8 IL1A IL1B IL6 TNF
50 11.72 FCGR2A FCGR3B FPR1 IL10

GO Terms for Aggressive Periodontitis

Cellular components related to Aggressive Periodontitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.77 CTSC CXCL8 DEFB1 FCGR3B IL10 IL1A
2 extracellular space GO:0005615 9.4 CTSC CXCL8 DEFB1 IL10 IL1A IL1B
3 secretory granule membrane GO:0030667 9.33 FCGR2A FCGR3B FPR1

Biological processes related to Aggressive Periodontitis according to GeneCards Suite gene sharing:

(show top 50) (show all 58)
# Name GO ID Score Top Affiliating Genes
1 defense response to bacterium GO:0042742 9.98 DEFB1 IL10 TLR4 TNF
2 response to lipopolysaccharide GO:0032496 9.97 CXCL8 IL10 IL1B TLR4
3 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 9.92 IL1A IL1B TLR4 TNF TNFSF11
4 regulation of signaling receptor activity GO:0010469 9.91 CXCL8 IL10 IL1A IL1B IL1RN IL4
5 response to organic substance GO:0010033 9.89 CTSC IL10 TNF
6 defense response to Gram-positive bacterium GO:0050830 9.89 DEFB1 IL6 TNF
7 interleukin-1-mediated signaling pathway GO:0070498 9.89 IL1A IL1B IL1RN
8 activation of MAPK activity GO:0000187 9.89 FPR1 IL1B TLR4 TNF
9 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.89 IL1B IL6 TLR4 TNF TNFSF11
10 defense response to Gram-negative bacterium GO:0050829 9.88 DEFB1 IL6 TLR4
11 cellular response to lipopolysaccharide GO:0071222 9.88 CXCL8 IL10 IL6 TLR4 TNF
12 positive regulation of T cell proliferation GO:0042102 9.85 IL1B IL4 IL6
13 response to glucocorticoid GO:0051384 9.84 IL10 IL1RN IL6 TNF
14 positive regulation of DNA binding transcription factor activity GO:0051091 9.83 IL10 IL1B IL6 TNF TNFSF11
15 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.82 IL1B TLR4 TNF
16 positive regulation of interferon-gamma production GO:0032729 9.81 IL1B TLR4 TNF
17 inflammatory response GO:0006954 9.81 CXCL8 FPR1 IL10 IL1A IL1B IL1RN
18 positive regulation of nitric oxide biosynthetic process GO:0045429 9.8 IL1B TLR4 TNF
19 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001240 9.79 IL1A IL1B TNF
20 lipopolysaccharide-mediated signaling pathway GO:0031663 9.77 IL1B TLR4 TNF
21 positive regulation of JNK cascade GO:0046330 9.77 IL1A IL1B TLR4 TNF TNFSF11
22 positive regulation of cytokine secretion GO:0050715 9.76 IL10 IL1A TNF
23 positive regulation of interleukin-8 production GO:0032757 9.75 IL1B TLR4 TNF
24 negative regulation of interleukin-6 production GO:0032715 9.74 IL10 TLR4 TNF
25 positive regulation of chemokine production GO:0032722 9.73 IL6 TLR4 TNF
26 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.72 IL1B TNF
27 regulation of osteoclast differentiation GO:0045670 9.72 TNF TNFSF11
28 positive regulation of macrophage activation GO:0043032 9.72 IL10 TLR4
29 negative regulation of growth of symbiont in host GO:0044130 9.72 IL10 TNF
30 positive regulation of interleukin-6 production GO:0032755 9.72 IL1A IL1B IL6 TLR4 TNF
31 response to molecule of bacterial origin GO:0002237 9.71 CXCL8 IL10
32 positive regulation of interleukin-2 biosynthetic process GO:0045086 9.71 IL1A IL1B
33 positive regulation of monocyte chemotactic protein-1 production GO:0071639 9.7 IL1A IL1B
34 negative regulation of heterotypic cell-cell adhesion GO:0034115 9.7 IL10 IL1RN
35 negative regulation of lipid storage GO:0010888 9.7 IL6 TNF
36 positive regulation of chemokine biosynthetic process GO:0045080 9.69 IL1B TNF
37 positive regulation of interleukin-8 biosynthetic process GO:0045416 9.69 TLR4 TNF
38 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.69 IL10 IL1B TNF
39 endothelial cell apoptotic process GO:0072577 9.68 IL10 TNF
40 ectopic germ cell programmed cell death GO:0035234 9.68 IL1A IL1B
41 regulation of establishment of endothelial barrier GO:1903140 9.68 IL1B TNF
42 negative regulation of cytokine secretion involved in immune response GO:0002740 9.66 IL10 TNF
43 type 2 immune response GO:0042092 9.66 IL10 IL4
44 positive regulation of fever generation GO:0031622 9.65 IL1B TNF
45 negative regulation of interleukin-1-mediated signaling pathway GO:2000660 9.65 IL1RN IL6
46 cytokine-mediated signaling pathway GO:0019221 9.65 CXCL8 FPR1 IL10 IL1A IL1B IL1RN
47 regulation of isotype switching GO:0045191 9.63 IL10 IL4
48 sequestering of triglyceride GO:0030730 9.63 IL1B TNF
49 positive regulation of MHC class II biosynthetic process GO:0045348 9.63 IL10 IL4 TLR4
50 receptor biosynthetic process GO:0032800 9.61 IL10 TNF

Molecular functions related to Aggressive Periodontitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.28 CXCL8 IL10 IL1A IL1B IL1RN IL4
2 IgG binding GO:0019864 9.16 FCGR2A FCGR3B
3 interleukin-1 receptor binding GO:0005149 9.13 IL1A IL1B IL1RN

Sources for Aggressive Periodontitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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