MCID: AGG001
MIFTS: 56

Aggressive Periodontitis

Categories: Bone diseases, Genetic diseases, Oral diseases

Aliases & Classifications for Aggressive Periodontitis

MalaCards integrated aliases for Aggressive Periodontitis:

Name: Aggressive Periodontitis 12 45 15 17
Periodontitis, Juvenile 74
Juvenile Periodontitis 12

Classifications:



External Ids:

Disease Ontology 12 DOID:1474
MeSH 45 D010520
SNOMED-CT 69 2624008 49965002
ICD10 34 K05.2
UMLS 74 C0031106

Summaries for Aggressive Periodontitis

Disease Ontology : 12 A periodontitis that is characterized by rapid attachment loss and bone destruction in the presence of little local factors such as dental plaque and dental calculus resulting in inflammation and a loss of periodontium.

MalaCards based summary : Aggressive Periodontitis, also known as periodontitis, juvenile, is related to periodontitis, chronic and diabetes mellitus. An important gene associated with Aggressive Periodontitis is PDON2 (Periodontitis, Localized Aggressive), and among its related pathways/superpathways are Innate Immune System and PEDF Induced Signaling. The drugs Estradiol and Ethinyl Estradiol have been mentioned in the context of this disorder. Affiliated tissues include bone, neutrophil and monocytes, and related phenotypes are hematopoietic system and homeostasis/metabolism

Wikipedia : 77 Aggressive periodontitis describes a type of periodontal disease and includes two of the seven... more...

Related Diseases for Aggressive Periodontitis

Diseases in the Aggressive Periodontitis family:

Periodontitis, Aggressive, 1 Periodontitis, Aggressive, 2

Diseases related to Aggressive Periodontitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 335)
# Related Disease Score Top Affiliating Genes
1 periodontitis, chronic 31.9 IL1B IL6 MMP8 TNFSF11
2 diabetes mellitus 30.2 IL1A IL1B IL1RN IL6 TNF
3 spondylitis 30.0 IL1RN IL6 TNF
4 gingivitis 29.6 CXCL8 IL1A IL1B IL4 IL6 MMP8
5 endocarditis 29.5 CXCL8 FCGR2A IL10 IL6 TNF
6 periodontosis 29.2 CXCL8 TLR4 TNF TNFSF11
7 arthritis 29.0 CXCL8 IL10 IL1A IL1B IL1RN IL6
8 bacterial infectious disease 28.8 CXCL8 FPR1 IL10 IL1B IL6 TLR4
9 periodontitis 28.5 TNFSF11 TNF TLR4 PDON2 MMP8 IL6
10 periodontal disease 28.2 TNFSF11 TNF TLR4 MMP8 IL6 IL1RN
11 rheumatoid arthritis 28.0 CXCL8 IL10 IL1A IL1B IL1RN IL4
12 susceptibility to localized juvenile periodontitis 12.2
13 periodontitis, aggressive, 1 11.6
14 papillon-lefevre syndrome 11.5
15 chronic follicular conjunctivitis 10.5 IL1A IL1B
16 kashin-beck disease 10.5 IL1B TNF
17 skin conditions 10.5 IL1A TNF
18 staphylococcal toxic shock syndrome 10.5 IL1B TNF
19 transient hypogammaglobulinemia 10.5 IL10 TNF
20 scleral disease 10.5 IL1RN TNF
21 multifocal choroiditis 10.5 IL10 TNF
22 punctate inner choroidopathy 10.5 IL10 TNF
23 angioimmunoblastic lymphadenopathy with dysproteinemia 10.5 IL6 TNF
24 critical limb ischemia 10.5 IL6 TNF
25 pustulosis of palm and sole 10.5 IL1RN TNF
26 autoimmune myocarditis 10.5 IL6 TNF
27 leukomalacia 10.5 IL6 TNF
28 scorpion envenomation 10.5 IL6 TNF
29 cardiogenic shock 10.5 IL6 TNF
30 eye lymphoma 10.5 IL10 IL6
31 acute cholangitis 10.5 IL1RN IL6
32 autoimmune vasculitis 10.5 IL1B IL4
33 cryopyrin-associated periodic syndrome 10.5 IL1RN IL6
34 congenital hypogammaglobulinemia 10.5 IL1A IL4
35 nickel allergic contact dermatitis 10.5 IL10 IL4
36 hyperlucent lung 10.5 IL10 IL4
37 b-cell growth factor 10.5 IL4 IL6
38 leukoregulin 10.4 CXCL8 IL1A
39 vulvovaginitis 10.4 CXCL8 IL10
40 neurosyphilis 10.4 CXCL8 IL10
41 familial mediterranean fever 10.4 IL1B IL1RN TNF
42 rheumatic disease 10.4 IL10 IL1B TNF
43 demyelinating disease 10.4 IL10 IL1B TNF
44 arteries, anomalies of 10.4 IL1B IL6 TNF
45 extrapulmonary tuberculosis 10.4 IL10 IL1B IL1RN
46 chikungunya 10.4 IL1B IL6 TNF
47 acquired metabolic disease 10.4 IL1B IL6 TNF
48 endometritis 10.4 IL1B IL6 TNF
49 lyme disease 10.4 IL1B IL6 TNF
50 glucose metabolism disease 10.4 IL1B IL6 TNF

Graphical network of the top 20 diseases related to Aggressive Periodontitis:



Diseases related to Aggressive Periodontitis

Symptoms & Phenotypes for Aggressive Periodontitis

MGI Mouse Phenotypes related to Aggressive Periodontitis:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.28 CTSC FCGR2A FCGR3B FPR1 IL10 IL1A
2 homeostasis/metabolism MP:0005376 10.25 CTSC FCGR3B FPR1 IL10 IL1A IL1B
3 immune system MP:0005387 10.24 CTSC FCGR2A FCGR3B FPR1 IL10 IL1A
4 integument MP:0010771 10.06 CTSC IL10 IL1A IL1B IL1RN IL4
5 mortality/aging MP:0010768 10 FCGR2A FPR1 IL10 IL1B IL1RN IL4
6 neoplasm MP:0002006 9.76 IL10 IL1A IL1B IL6 MMP8 TLR4
7 reproductive system MP:0005389 9.56 IL10 IL1RN IL4 IL6 TLR4 TNF
8 skeleton MP:0005390 9.36 FCGR2A FCGR3B IL10 IL1B IL1RN IL4

Drugs & Therapeutics for Aggressive Periodontitis

Drugs for Aggressive Periodontitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 79)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Estradiol Approved, Investigational, Vet_approved Phase 4 50-28-2 5757
2
Ethinyl Estradiol Approved Phase 4 57-63-6 5991
3
Amoxicillin Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 26787-78-0 33613
4
Polyestradiol phosphate Approved Phase 4 28014-46-2
5
Moxifloxacin Approved, Investigational Phase 4 354812-41-2, 151096-09-2 152946
6
Metronidazole Approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 443-48-1 4173
7
Norgestimate Approved, Investigational Phase 4 35189-28-7 6540478
8
Chlorhexidine Approved, Vet_approved Phase 4 55-56-1 2713 9552079
9 sodium fluoride Approved Phase 4 7681-49-4
10
Triclosan Approved, Investigational Phase 4 3380-34-5 5564
11 Anti-Bacterial Agents Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
12 Contraceptive Agents Phase 4
13 Anti-Infective Agents Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
14 Contraceptives, Oral Phase 4
15 Anesthetics Phase 4,Not Applicable
16 Antiparasitic Agents Phase 4,Phase 2,Phase 3,Phase 1
17 Topoisomerase Inhibitors Phase 4
18 Antibiotics, Antitubercular Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
19 Estradiol 17 beta-cypionate Phase 4
20 Estradiol 3-benzoate Phase 4
21 Norgestimate, ethinyl estradiol drug combination Phase 4
22 Contraceptives, Oral, Combined Phase 4
23 Antiprotozoal Agents Phase 4,Phase 2,Phase 3,Phase 1
24 Chlorhexidine gluconate Phase 4
25 Protective Agents Phase 4
26 Fluorides Phase 4
27 Listerine Phase 4
28 Lipid Regulating Agents Phase 4
29 Cariostatic Agents Phase 4
30 Anti-Infective Agents, Local Phase 4
31 Antimetabolites Phase 4
32 Hypolipidemic Agents Phase 4
33 Anesthetics, Local Phase 4
34
Clarithromycin Approved Phase 2, Phase 3,Phase 3,Not Applicable 81103-11-9 84029
35
Aspirin Approved, Vet_approved Phase 2, Phase 3,Phase 3 50-78-2 2244
36 Cytochrome P-450 CYP3A Inhibitors Phase 2, Phase 3,Phase 3,Not Applicable
37 Cytochrome P-450 Enzyme Inhibitors Phase 2, Phase 3,Phase 3,Not Applicable
38 Cyclooxygenase Inhibitors Phase 2, Phase 3,Phase 3
39 Anti-Inflammatory Agents, Non-Steroidal Phase 2, Phase 3,Phase 3
40 Antipyretics Phase 2, Phase 3,Phase 3
41 Anti-Inflammatory Agents Phase 2, Phase 3,Phase 3
42 Fibrinolytic Agents Phase 2, Phase 3,Phase 3
43 Peripheral Nervous System Agents Phase 2, Phase 3,Phase 3
44 Platelet Aggregation Inhibitors Phase 2, Phase 3,Phase 3
45 Omega 3 Fatty Acid Phase 2, Phase 3,Phase 3
46 Antirheumatic Agents Phase 2, Phase 3,Phase 3
47 Analgesics, Non-Narcotic Phase 2, Phase 3,Phase 3
48 Analgesics Phase 2, Phase 3,Phase 3
49
Doxycycline Approved, Investigational, Vet_approved Phase 1, Phase 2 564-25-0 54671203
50 Antimalarials Phase 1, Phase 2

Interventional clinical trials:

(show all 46)
# Name Status NCT ID Phase Drugs
1 Efficacy of Three Antibiotic Protocols for Aggressive Periodontitis Treatment Unknown status NCT02839421 Phase 4 Scaling and Root Planing combined with moxifloxacin
2 Adjunctive Systemic Administration of Moxifloxacin in the Treatment of Aggressive Periodontitis Completed NCT02125812 Phase 4
3 Evaluation of Efficacy of Full-mouth Disinfection in Generalized Aggressive Periodontitis Patients Completed NCT02466646 Phase 4 Klorhex® Gel, rinse and sprey
4 Triclosan as Adjunctive Therapy in the Plaque Control in Children From Generalized Aggressive Periodontitis Families. Completed NCT03642353 Phase 4 Triclosan;Placebo
5 Treatment of Aggressive Periodontitis With Repeated Adjunctive Antimicrobial Photodynamic Therapy Completed NCT02049008 Phase 4
6 Host Modulatory Effects of β-glucan on Localized Aggressive Periodontitis Completed NCT02402296 Phase 4 β-1,3/1,6-D-glucan
7 Alternative Antibiotic Regime in the Treatment of GAgP Completed NCT02223702 Phase 4 Amoxicillin;Metronidazole;Moxifloxacin
8 Enamel Matrix Proteins in the Treatment of Intrabony Defects in Patients With Aggressive and Chronic Periodontitis Completed NCT03025204 Phase 4
9 Two Different Antibiotic Agents to Treat Generalized Aggressive Periodontitis Completed NCT02969928 Phase 2, Phase 3 Clarithromycin;Amoxicillin;Metronidazole
10 Periodontal Debridement Associated With Systemic Antibiotics and Single/Repeated PDT to Treat Aggressive Periodontitis Completed NCT03132714 Phase 2, Phase 3 Amoxicillin 500mg;Metronidazole 400mg;Clarithromycin 500mg
11 Omega-3 Plus Low-dose Aspirin Daily Supplementation in Non-surgical Therapy to Treat Aggressive Periodontitis Recruiting NCT03093246 Phase 2, Phase 3 Aspirin
12 Omega-3 Fatty Acids Plus Low-dose Aspirin Daily Supplementation in Surgical Therapy to Treat Aggressive Periodontitis Recruiting NCT03093207 Phase 2, Phase 3 Aspirin
13 Doxycycline in the Treatment of Aggressive Periodontitis Completed NCT03727620 Phase 1, Phase 2 amoxicillin plus metronidazole;Doxycycline
14 The Affect of Orthodontic Treatment on the Periodontal Status of Patients With Aggressive Periodontitis Unknown status NCT01510808
15 Subgingival Microbiome Following Mechanical Treatment and it's Effect on Peri-implant Sub-mucosa in Aggressive Periodontitis Patients Unknown status NCT03090282
16 Polymorphonuclear Cells' Sensitivity to Aggregatibacter Actinomycetemcomitans Bacteria in Patients With Aggressive Periodontitis Unknown status NCT02010307 Not Applicable
17 Chronic Presence of Epstein Barr Virus in Epithelial Cells From Gingiva is Associated With Periodontitis Unknown status NCT01246596 Not Applicable
18 B Cell Functions in Periodontitis Unknown status NCT02833285
19 Immunolocalization of 1,25,Dihydroxyvitamin D3 in Aggressive Periodontitis Patients Completed NCT02282800
20 Gene Expression Profiles in Generalized Aggressive Periodontitis: A Gene Network-based Microarray Analysis Completed NCT02327533
21 Effects of Smoking on Non-surgical Periodontal Therapy in Generalized Aggressive Periodontitis Completed NCT03512938 Not Applicable
22 Effects Of Adjunctive Photodynamic Therapy To Non-Surgical Periodontal Treatment In Patients With Generalized Aggressive Periodontitis Completed NCT03412331 Not Applicable
23 Gingival Crevicular Fluid Levels Of Monocyte Chemoattractant Protein-1 Completed NCT02927704
24 Frequency Of MCP-1 And CCR2 Gene Polymorphisms And Its Effect On Gene Expression In Patients With AgP Completed NCT02817568
25 Effects of Er,Cr:YSGG, Diode Lasers on GCF Cytokines Levels Completed NCT03034824 Not Applicable
26 Clarithromycin as Adjuvant to Periodontal Debridement Completed NCT02829983 Not Applicable Clarithromycin;Placebo
27 Smoking Influence on Apoptosis in Periodontitis Completed NCT02111005
28 Nonsurgical Periodontal Treatment Associated or Not With Systemic Antibiotics and Photodynamic Therapy Completed NCT03142776 Not Applicable systemic clarithromycin
29 Tissue Alterations in Aggressive and Chronic Periodontitis Completed NCT03625414
30 Effect of Surgical Therapy on RANKL/OPG (Osteoprotegerin) System Completed NCT02190773
31 Estimation of Pentrexin-3 Levels in GCF and Saliva of Patients With Periodontal Disease Completed NCT03128502
32 Clinical, Immunological and Microbiological Evaluation of Experimental Gingivitis and Peri-implant Mucositis Completed NCT03713567 Not Applicable
33 Nitro-oxidative Stress in Periodontitis Completed NCT02127203
34 TNF-α/HIF-1α/VEGF Pathway in Periodontal Diseases Completed NCT03558906
35 Active Matrix Metalloproteinase-8 (aMMP-8) Chair-side Test in Different Periodontal Disease Completed NCT03527901
36 The Importance of Periostin in Periodontal Health and Disease Completed NCT01180920
37 Gingival Bleeding and Von Willebrand Disease Typ 2 and 3 Completed NCT03078595
38 Perforated Collagen Membrane With Nanohydroxyapatite for Intrabony Defects Completed NCT03399279 Not Applicable
39 Immediate Implant Placement in Aggressive Periodontitis Recruiting NCT03218228 Not Applicable
40 EMD for Treatment of Proximal Class-II Furcation Involvements Recruiting NCT03320135 Not Applicable
41 Mechanisms and Treatment Response of Aggressive Periodontitis in Children Active, not recruiting NCT01330719 Not Applicable
42 Comparison Between Surgical Access and Repeated Applications of APDT Active, not recruiting NCT03140059 Not Applicable
43 Interaction Between Immune Cells and Bacteria Associated With Periodontitis Active, not recruiting NCT03225950
44 Long-term Results After Systematic Periodontal Therapy Enrolling by invitation NCT03048045
45 Clinical and Radiographic Evaluation of Guided Tissue Regeneration With Radiation-sterilized Allogenic Bone Grafts or Xenogenic Grafts for the Treatment of Intrabony Defects in Aggressive Periodontitis Not yet recruiting NCT03340012 Not Applicable
46 Analysis of Osteoimmune Interactions Linking Inflammation and Bone Destruction in Aggressive Periodontitis Terminated NCT01993368 Not Applicable

Search NIH Clinical Center for Aggressive Periodontitis

Cochrane evidence based reviews: aggressive periodontitis

Genetic Tests for Aggressive Periodontitis

Anatomical Context for Aggressive Periodontitis

MalaCards organs/tissues related to Aggressive Periodontitis:

42
Bone, Neutrophil, Monocytes, Testes, B Cells, Colon, Whole Blood

Publications for Aggressive Periodontitis

Articles related to Aggressive Periodontitis:

(show top 50) (show all 738)
# Title Authors Year
1
Six-month clinical outcomes of non-surgical periodontal treatment with antibiotics on apoptosis markers in aggressive periodontitis. ( 30614174 )
2019
2
One-year follow-up of the immune profile in serum and selected sites of generalized and localized aggressive periodontitis. ( 30684915 )
2019
3
Protein carbonyl levels in serum, saliva and gingival crevicular fluid in patients with chronic and aggressive periodontitis. ( 30705565 )
2019
4
Comparison of the oral microbiome of patients with generalized aggressive periodontitis and periodontitis-free subjects. ( 30710838 )
2019
5
A Double-Crown Concept for Restorations in Patients with Generalized Aggressive Periodontitis: Two Case Reports with 22- and 25-Year Follow-ups. ( 30794256 )
2019
6
Regeneration of the Periodontal Apparatus in Aggressive Periodontitis Patients. ( 30857253 )
2019
7
Response to "Identification of genetic risk factors of aggressive periodontitis using genome-wide association studies in association with those of chronic periodontitis". ( 30900245 )
2019
8
Management of periodontic-endodontic lesion in aggressive periodontitis-9 months follow-up: Report of a case. ( 30900677 )
2019
9
Subgingival microbiome in Chinese patients with generalized aggressive periodontitis compared to healthy controls. ( 30909081 )
2019
10
Comparison of Subgingival and Buccal Mucosa Microbiome in Chronic and Aggressive Periodontitis: A Pilot Study. ( 30915280 )
2019
11
Discrepancy of Clinical Parameters between the First and Second Molars Can Help to Differentiate Subjects with Aggressive Periodontitis from Chronic Periodontitis: a Cross-sectional Study Based on a Large Chinese Population. ( 29808177 )
2018
12
Diagnosis of aggressive periodontitis: A dilemma? ( 29363676 )
2018
13
Consanguinity increases the risk for aggressive periodontitis. ( 29947052 )
2018
14
Feasibility of using allograft bone with resorbable collagen membrane for alveolar ridge vertical defect augmentation for dental implant placement in Patient with Aggressive Periodontitis: A case report. ( 29942111 )
2018
15
The Subgingival Microbiome of Periodontal Pockets With Different Probing Depths in Chronic and Aggressive Periodontitis: A Pilot Study. ( 29765908 )
2018
16
12 years' preservation of maxillary permanent incisors with cervical root fractures adjacent to aggressive periodontitis: Report of a case. ( 29786703 )
2018
17
Assessment of Lipid Peroxidation Levels and Total Antioxidant Status in Chronic and Aggressive Periodontitis Patients: An in vivo Study. ( 29603700 )
2018
18
Analysis of metabolic profiles of generalized aggressive periodontitis. ( 29974463 )
2018
19
Management of localized aggressive periodontitis: A 30-year follow-up. ( 29930995 )
2018
20
Definition of aggressive periodontitis in periodontal research. A systematic review. ( 29226356 )
2018
21
Radiographic morphology of intrabony defects in the first molars of patients with localized aggressive periodontitis: Comparison with health and chronic periodontitis. ( 29660823 )
2018
22
Classification and diagnosis of aggressive periodontitis. ( 29926487 )
2018
23
Interleukin-17 and interleukin-23 levels in gingival crevicular fluid of patients with chronic and aggressive periodontitis. ( 29736149 )
2018
24
A novel U-shaped relationship between BMI and risk of generalized aggressive periodontitis in Chinese: A cross-sectional study. ( 29944736 )
2018
25
Clinical performance of non-surgical periodontal therapy in a large Chinese population with generalized aggressive periodontitis. ( 29974483 )
2018
26
Association between circulating levels of heat-shock protein 27 and aggressive periodontitis. ( 29766408 )
2018
27
Localization and density of Porphyromonas gingivalis and Tannerella forsythia in gingival and subgingival granulation tissues affected by chronic or aggressive periodontitis. ( 29934515 )
2018
28
Localised aggressive periodontitis in a 3-year-old-boy. ( 29332208 )
2018
29
Impact of aggressive periodontitis and chronic periodontitis on oral health-related quality of life. ( 29451591 )
2018
30
Classification and diagnosis of aggressive periodontitis. ( 29926947 )
2018
31
Treatment of intrabony defects with modified perforated membranes in aggressive periodontitis: a 12-month randomized controlled trial. ( 29411112 )
2018
32
Single Sitting Surgical Treatment of Generalized Aggressive Periodontitis Using GTR Technique and Immediate Implant Placement with 10-Year Follow-Up. ( 29607223 )
2018
33
Outcomes After 25 Years of Periodontal Treatment and Maintenance of a Patient Affected by Generalized Severe Aggressive Periodontitis. ( 29641623 )
2018
34
mRNA expression OF IFN-I>s in the gingival tissue of chronic and aggressive periodontitis patients: A polymerase chain reaction study. ( 29717481 )
2018
35
CCR5I932 (rs333) polymorphism is associated with decreased risk of chronic and aggressive periodontitis: A case-control analysis based in disease resistance and susceptibility phenotypes. ( 28969941 )
2018
36
Association analysis of FAS-670A/G and FASL-844C/T polymorphisms with risk of generalized aggressive periodontitis disease. ( 29541461 )
2018
37
Human herpesviruses may be associated with the development of aggressive periodontitis. ( 29548690 )
2018
38
Aggressive periodontitis presents a higher degree of bilateral symmetry in comparison with chronic periodontitis. ( 29576581 )
2018
39
Visfatin expression in gingival tissues of chronic periodontitis and aggressive periodontitis patients: An immunohistochemical analysis. ( 29576773 )
2018
40
Orthodontic treatment in patients with aggressive periodontitis. ( 29602347 )
2018
41
Validation of reported GLT6D1 (rs1537415), IL10 (rs6667202), and ANRIL (rs1333048) single nucleotide polymorphisms for aggressive periodontitis in a Brazilian population. ( 30030838 )
2018
42
Superoxide Dismutase, Uric Acid, Total Antioxidant Status, and Lipid Peroxidation Assay in Chronic and Aggressive Periodontitis Patients. ( 30066694 )
2018
43
Efficacy of adjunctive photodynamic therapy in the treatment of generalized aggressive periodontitis: A randomized controlled clinical trial. ( 30095173 )
2018
44
Gingival Recession and Localized Aggressive Periodontitis Among HIV-Infected Children and Adolescents Receiving Antiretroviral Therapy. ( 30096098 )
2018
45
Vitamin D deficiency in patients with aggressive periodontitis. ( 30169905 )
2018
46
Efficacy of adjunctive low-level laser therapy in the treatment of aggressive periodontitis: A systematic review. ( 30198204 )
2018
47
A comparative study of synbiotic as an add-on therapy to standard treatment in patients with aggressive periodontitis. ( 30210194 )
2018
48
Oral health-related quality of life and standard of treatment in aggressive periodontitis patients more than 5 years after therapy. ( 30216484 )
2018
49
Evaluation of the local effect of nonsurgical periodontal treatment with and without systemic antibiotic and photodynamic therapy in generalized aggressive periodontitis. A randomized clinical trial. ( 30227258 )
2018
50
Identification of genetic risk factors of aggressive periodontitis using genomewide association studies in association with those of chronic periodontitis. ( 30303256 )
2018

Variations for Aggressive Periodontitis

Expression for Aggressive Periodontitis

Search GEO for disease gene expression data for Aggressive Periodontitis.

Pathways for Aggressive Periodontitis

Pathways related to Aggressive Periodontitis according to GeneCards Suite gene sharing:

(show top 50) (show all 72)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14.04 CTSC CXCL8 FCGR2A FCGR3B FPR1 IL10
2
Show member pathways
13.74 CXCL8 IL10 IL1A IL1B IL1RN IL4
3
Show member pathways
13.48 CXCL8 IL10 IL1A IL1B IL4 IL6
4
Show member pathways
13.44 CXCL8 FPR1 IL10 IL1A IL1B IL1RN
5
Show member pathways
13.37 CXCL8 IL10 IL1A IL1B IL4 IL6
6
Show member pathways
13.22 CXCL8 IL10 IL1B IL6 TLR4 TNF
7
Show member pathways
12.97 CXCL8 IL10 IL1A IL1B IL4 IL6
8
Show member pathways
12.79 CXCL8 IL1B IL6 TLR4 TNF
9
Show member pathways
12.74 IL1A IL1B IL6 TLR4 TNF
10
Show member pathways
12.71 IL10 IL1A IL1B IL4 IL6 TLR4
11
Show member pathways
12.7 CXCL8 IL1A IL1B IL4 IL6 TLR4
12 12.67 IL10 IL1B IL1RN IL4 TNF TNFSF11
13
Show member pathways
12.66 IL1A IL1B TLR4 TNF TNFSF11
14
Show member pathways
12.55 IL10 IL1A IL1B IL4 IL6 TNF
15
Show member pathways
12.44 CXCL8 IL1A IL1B IL6 TLR4 TNF
16
Show member pathways
12.43 CXCL8 IL1B IL4 IL6 TNF
17
Show member pathways
12.38 CXCL8 IL10 IL1A IL1B IL4 IL6
18
Show member pathways
12.37 IL1B IL4 IL6 TNF
19
Show member pathways
12.37 CXCL8 IL1A IL6 TLR4 TNF
20
Show member pathways
12.35 FCGR2A FCGR3B IL10 IL1A IL1B IL4
21
Show member pathways
12.34 CXCL8 IL1A IL1B IL1RN IL6 TNF
22
Show member pathways
12.3 CXCL8 IL1B IL4 IL6 TLR4 TNF
23 12.3 CXCL8 IL10 IL1A IL1B IL1RN IL6
24
Show member pathways
12.26 IL10 IL1B IL6 TNF
25
Show member pathways
12.26 IL1A IL1B TLR4 TNF
26
Show member pathways
12.24 CXCL8 IL1A IL1B MMP8 TLR4
27
Show member pathways
12.19 IL10 IL1B IL6 TLR4 TNF
28
Show member pathways
12.18 CXCL8 IL10 IL1A IL1B IL4 IL6
29
Show member pathways
12.18 FCGR2A FCGR3B IL1B IL4 IL6 TLR4
30 12.16 FCGR2A FCGR3B IL1A IL1B TNF TNFSF11
31 12.13 FCGR2A IL10 IL4 IL6 TNF
32 12.12 CXCL8 IL10 IL1A IL1B IL4 IL6
33 12.06 FCGR2A FCGR3B IL10 IL1A IL1B IL6
34 12.05 CXCL8 IL1A IL1B IL6 TNF
35 12.04 CXCL8 IL1A IL1B IL6
36 12.03 IL1A IL1B IL4 IL6 TNF
37 12.02 CXCL8 IL1B TLR4 TNF TNFSF11
38 12.02 CXCL8 IL10 IL1B IL6 TLR4 TNF
39 11.97 CXCL8 IL1A IL1B IL6 TLR4
40 11.96 IL1B IL6 TNF
41 11.94 CXCL8 IL1A IL1B IL6 TLR4 TNF
42 11.94 CXCL8 FCGR2A IL1A IL1B IL4 IL6
43 11.9 IL10 IL1B IL4 TNF
44
Show member pathways
11.89 CXCL8 IL6 TLR4
45 11.87 IL10 IL1B IL6 TNF
46 11.84 FCGR2A FCGR3B TLR4
47 11.83 CXCL8 IL4 IL6
48 11.82 FCGR2A FCGR3B FPR1 IL10
49 11.8 CXCL8 IL1B IL4 IL6 TNF
50
Show member pathways
11.79 CXCL8 IL4 TNF

GO Terms for Aggressive Periodontitis

Cellular components related to Aggressive Periodontitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.7 CTSC CXCL8 IL10 IL1A IL1B IL1RN
2 extracellular region GO:0005576 9.4 CTSC CXCL8 FCGR3B IL10 IL1A IL1B
3 secretory granule membrane GO:0030667 9.33 FCGR2A FCGR3B FPR1

Biological processes related to Aggressive Periodontitis according to GeneCards Suite gene sharing:

(show top 50) (show all 60)
# Name GO ID Score Top Affiliating Genes
1 cellular response to lipopolysaccharide GO:0071222 9.98 CXCL8 IL10 IL1B IL1RN IL6 TLR4
2 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 9.97 IL1B IL1RN TLR4 TNF TNFSF11
3 positive regulation of gene expression GO:0010628 9.97 IL1A IL1B IL4 IL6 MMP8 TLR4
4 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.96 IL1B IL6 TLR4 TNF TNFSF11
5 activation of MAPK activity GO:0000187 9.93 FPR1 IL1B TLR4 TNF
6 positive regulation of JNK cascade GO:0046330 9.93 IL1B IL1RN MMP8 TLR4 TNF TNFSF11
7 positive regulation of DNA-binding transcription factor activity GO:0051091 9.91 IL10 IL1B IL6 TNF TNFSF11
8 response to organic substance GO:0010033 9.89 CTSC IL10 TNF
9 neutrophil chemotaxis GO:0030593 9.89 CXCL8 IL1B IL1RN
10 positive regulation of T cell proliferation GO:0042102 9.87 IL1B IL4 IL6
11 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.87 IL1B MMP8 TLR4 TNF
12 interleukin-1-mediated signaling pathway GO:0070498 9.86 IL1A IL1B IL1RN
13 positive regulation of interferon-gamma production GO:0032729 9.85 IL1B TLR4 TNF
14 positive regulation of nitric oxide biosynthetic process GO:0045429 9.85 IL1B MMP8 TLR4 TNF
15 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001240 9.82 IL1A IL1B TNF
16 lipopolysaccharide-mediated signaling pathway GO:0031663 9.81 IL1B TLR4 TNF
17 inflammatory response GO:0006954 9.81 CXCL8 FPR1 IL10 IL1A IL1B IL1RN
18 negative regulation of interleukin-6 production GO:0032715 9.8 IL10 TLR4 TNF
19 positive regulation of cytokine secretion GO:0050715 9.8 IL10 IL1A TNF
20 positive regulation of interleukin-8 production GO:0032757 9.79 IL1B TLR4 TNF
21 negative regulation of neurogenesis GO:0050768 9.79 IL1B IL6 TNF
22 positive regulation of chemokine production GO:0032722 9.78 IL6 TLR4 TNF
23 response to glucocorticoid GO:0051384 9.78 IL10 IL1RN IL6 TNF
24 positive regulation of glial cell proliferation GO:0060252 9.77 IL1B IL6 TNF
25 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.76 IL10 IL1B TNF
26 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.73 IL1B TNF
27 negative regulation of growth of symbiont in host GO:0044130 9.73 IL10 TNF
28 positive regulation of interleukin-6 production GO:0032755 9.73 IL1B IL1RN IL6 MMP8 TLR4 TNF
29 regulation of osteoclast differentiation GO:0045670 9.72 TNF TNFSF11
30 positive regulation of reactive oxygen species biosynthetic process GO:1903428 9.72 MMP8 TLR4
31 positive regulation of interleukin-2 biosynthetic process GO:0045086 9.72 IL1A IL1B
32 response to molecule of bacterial origin GO:0002237 9.71 CXCL8 IL10
33 negative regulation of heterotypic cell-cell adhesion GO:0034115 9.71 IL10 IL1RN
34 positive regulation of interleukin-8 biosynthetic process GO:0045416 9.71 TLR4 TNF
35 negative regulation of lipid storage GO:0010888 9.71 IL6 TNF
36 positive regulation of MHC class II biosynthetic process GO:0045348 9.71 IL10 IL4 TLR4
37 positive regulation of neuroinflammatory response GO:0150078 9.71 IL1B IL6 MMP8 TNF
38 endothelial cell apoptotic process GO:0072577 9.7 IL10 TNF
39 positive regulation of chemokine biosynthetic process GO:0045080 9.7 IL1B TNF
40 ectopic germ cell programmed cell death GO:0035234 9.7 IL1A IL1B
41 regulation of establishment of endothelial barrier GO:1903140 9.69 IL1B TNF
42 negative regulation of cytokine secretion involved in immune response GO:0002740 9.69 IL10 TNF
43 negative regulation of interleukin-1-mediated signaling pathway GO:2000660 9.68 IL1RN IL6
44 positive regulation of fever generation GO:0031622 9.68 IL1B TNF
45 regulation of isotype switching GO:0045191 9.67 IL10 IL4
46 sequestering of triglyceride GO:0030730 9.67 IL1B TNF
47 type 2 immune response GO:0042092 9.67 IL10 IL4
48 fever generation GO:0001660 9.66 IL1A IL1B
49 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.65 IL1B TNF
50 receptor biosynthetic process GO:0032800 9.65 IL10 TNF

Molecular functions related to Aggressive Periodontitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.28 CXCL8 IL10 IL1A IL1B IL1RN IL4
2 IgG binding GO:0019864 9.16 FCGR2A FCGR3B
3 interleukin-1 receptor binding GO:0005149 9.13 IL1A IL1B IL1RN

Sources for Aggressive Periodontitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
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34 ICD10
35 ICD10 via Orphanet
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38 KEGG
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45 MeSH
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59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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