MCID: AGG001
MIFTS: 55

Aggressive Periodontitis

Categories: Bone diseases, Genetic diseases, Oral diseases

Aliases & Classifications for Aggressive Periodontitis

MalaCards integrated aliases for Aggressive Periodontitis:

Name: Aggressive Periodontitis 12 6 44 15 17
Periodontitis, Juvenile 70
Juvenile Periodontitis 12

Classifications:



External Ids:

Disease Ontology 12 DOID:1474
MeSH 44 D010520
SNOMED-CT 67 449908004
ICD10 32 K05.2
UMLS 70 C0031106

Summaries for Aggressive Periodontitis

Disease Ontology : 12 A periodontitis that is characterized by rapid attachment loss and bone destruction in the presence of little local factors such as dental plaque and dental calculus resulting in inflammation and a loss of periodontium.

MalaCards based summary : Aggressive Periodontitis, also known as periodontitis, juvenile, is related to periodontitis, chronic and periodontitis, aggressive, 1. An important gene associated with Aggressive Periodontitis is CTSC (Cathepsin C), and among its related pathways/superpathways are Innate Immune System and PEDF Induced Signaling. The drugs sodium fluoride and Triclosan have been mentioned in the context of this disorder. Affiliated tissues include neutrophil, bone and monocytes, and related phenotypes are homeostasis/metabolism and hematopoietic system

Wikipedia : 73 Aggressive periodontitis describes a type of periodontal disease and includes two of the seven... more...

Related Diseases for Aggressive Periodontitis

Diseases in the Aggressive Periodontitis family:

Periodontitis, Aggressive, 1 Periodontitis, Aggressive, 2

Diseases related to Aggressive Periodontitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 691)
# Related Disease Score Top Affiliating Genes
1 periodontitis, chronic 32.3 TNFSF11 MMP8 MMP1 IL6 IL1B
2 periodontitis, aggressive, 1 32.3 MMP8 MMP1 IL1A FPR1 CTSC
3 gingival recession 31.2 TNFSF11 TNF MMP8 IL6 IL1B
4 bone resorption disease 31.1 VDR TNFSF11 TNF IL6 IL1B
5 gingival overgrowth 30.7 TNF MMP8 MMP1 IL6 IL1A CXCL8
6 juvenile rheumatoid arthritis 30.7 TNF IL6 IL1RN IL1B IL10 CXCL8
7 periodontosis 30.6 GLT6D1 CTSC
8 gingivitis 30.6 TNF TLR2 MMP8 MMP1 IL6 IL4
9 tetanus 30.6 TNF IL6 IL4 IL1B IL1A IL10
10 actinomycosis 30.5 TNF IL6 IL4 IL1B IL10
11 infective endocarditis 30.5 TNF TLR2 IL6 FCGR2A
12 cutaneous lupus erythematosus 30.4 TNF IL6 IL1B IL10
13 root resorption 30.4 TNFSF11 IL6 IL4 IL1RN IL1B IL1A
14 sarcoidosis 1 30.4 TNF IL1RN IL1B IL1A
15 mental depression 30.3 TNF IL6 IL1B
16 spondylitis 30.3 TNFSF11 TNF IL6 IL1B IL10
17 spondyloarthropathy 1 30.2 TNFSF11 TNF TLR4 IL6 IL1RN
18 type 1 diabetes mellitus 30.2 VDR TNF TLR4 IL6 IL4 IL1RN
19 periodontitis 30.1 VDR TNFSF11 TNF TLR4 TLR2 PDON2
20 common variable immunodeficiency 30.0 TNF TLR2 IL6 IL4 IL1B IL1A
21 spondyloarthropathy 30.0 TNFSF11 TNF IL6 IL4 IL1B IL10
22 crohn's disease 30.0 TNF TLR4 TLR2 IL6 IL4 IL1B
23 endocarditis 30.0 TNF TLR2 IL6 IL1A IL10 FCGR2A
24 proteasome-associated autoinflammatory syndrome 1 29.9 TNF TLR4 TLR2 IL6 IL4 IL1RN
25 disease by infectious agent 29.8 TNF TLR4 TLR2 IL6 IL4 IL1RN
26 autoimmune disease 29.7 VDR TNF IL6 IL4 IL1RN IL1B
27 arthritis 29.6 TNFSF11 TNF TLR4 TLR2 MMP8 MMP1
28 bacterial infectious disease 29.6 TNF TLR4 TLR2 IL6 IL1RN IL1B
29 rheumatoid arthritis 29.2 TNFSF11 TNF TLR4 TLR2 MMP8 MMP1
30 susceptibility to localized juvenile periodontitis 11.1
31 papillon-lefevre syndrome 11.1
32 punctate inner choroidopathy 10.5 TNF IL10
33 external pathological resorption 10.5 TNF IL6
34 scorpion envenomation 10.5 TNF IL6
35 physiological polycythemia 10.5 TNF IL6 IL1B
36 palladium allergic contact dermatitis 10.5 TNF IL1B IL10
37 vulvar vestibulitis syndrome 10.5 TNF IL1RN IL1B
38 arachnoiditis 10.5 TNF IL1B IL1A
39 tropical endomyocardial fibrosis 10.5 TNF IL4 IL10
40 endomyocardial fibrosis 10.5 TNF IL4 IL10
41 indolent plasma cell myeloma 10.5 IL6 IL1B IL1A
42 meningococcemia 10.5 IL1RN IL1B IL1A
43 chemical colitis 10.5 TNF IL1B IL10
44 ulcer of lower limbs 10.5 TNF IL6 IL1B
45 staphylococcal toxic shock syndrome 10.5 TNF IL1B
46 carbuncle 10.5 TNF IL6 IL1B
47 tenosynovitis 10.5 TNF IL6 IL1B
48 paratyphoid fever 10.5 TNF IL1B IL1A
49 multifocal choroiditis 10.5 TNF IL10
50 bursitis 10.5 TNF IL6 IL1B

Graphical network of the top 20 diseases related to Aggressive Periodontitis:



Diseases related to Aggressive Periodontitis

Symptoms & Phenotypes for Aggressive Periodontitis

MGI Mouse Phenotypes related to Aggressive Periodontitis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.22 CTSC FCGR2A FPR1 IL10 IL1A IL1B
2 hematopoietic system MP:0005397 10.21 CTSC FCGR2A FPR1 IL10 IL1A IL1B
3 immune system MP:0005387 10.16 CTSC FCGR2A FPR1 IL10 IL1A IL1B
4 integument MP:0010771 9.93 CTSC IL10 IL1A IL1B IL1RN IL4
5 neoplasm MP:0002006 9.65 IL10 IL1A IL1B IL6 MMP1 MMP8
6 skeleton MP:0005390 9.36 FCGR2A IL10 IL1B IL1RN IL4 IL6

Drugs & Therapeutics for Aggressive Periodontitis

Drugs for Aggressive Periodontitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 63)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
sodium fluoride Approved Phase 4 7681-49-4
2
Triclosan Approved, Investigational Phase 4 3380-34-5 5564
3
Chlorhexidine Approved, Vet_approved Phase 4 55-56-1 2713 9552079
4
Amoxicillin Approved, Vet_approved Phase 4 26787-78-0 33613
5
Metronidazole Approved Phase 4 443-48-1 4173
6
Moxifloxacin Approved, Investigational Phase 4 354812-41-2, 151096-09-2 152946
7
Phenothiazine Experimental, Vet_approved Phase 4 92-84-2
8 Fluorides Phase 4
9 Anesthetics, Local Phase 4
10 Antimetabolites Phase 4
11 Anti-Infective Agents, Local Phase 4
12 Lipid Regulating Agents Phase 4
13 Listerine Phase 4
14 Protective Agents Phase 4
15 Hypolipidemic Agents Phase 4
16 Chlorhexidine gluconate Phase 4
17 Anesthetics Phase 4
18 Anti-Infective Agents Phase 4
19 Anti-Bacterial Agents Phase 4
20 Antibiotics, Antitubercular Phase 4
21 Norgestimate, ethinyl estradiol drug combination Phase 4
22
Clarithromycin Approved Phase 2, Phase 3 81103-11-9 84029
23
Aspirin Approved, Vet_approved Phase 2, Phase 3 50-78-2 2244
24 Cytochrome P-450 CYP3A Inhibitors Phase 2, Phase 3
25 Cytochrome P-450 Enzyme Inhibitors Phase 2, Phase 3
26 Analgesics, Non-Narcotic Phase 2, Phase 3
27 Omega 3 Fatty Acid Phase 2, Phase 3
28 Analgesics Phase 2, Phase 3
29 Fibrinolytic Agents Phase 2, Phase 3
30 Cyclooxygenase Inhibitors Phase 2, Phase 3
31 Antirheumatic Agents Phase 2, Phase 3
32 Antipyretics Phase 2, Phase 3
33 Platelet Aggregation Inhibitors Phase 2, Phase 3
34 Anti-Inflammatory Agents Phase 2, Phase 3
35 Anti-Inflammatory Agents, Non-Steroidal Phase 2, Phase 3
36
Doxycycline Approved, Investigational, Vet_approved Phase 1, Phase 2 564-25-0 54671203
37 Antimalarials Phase 1, Phase 2
38 Nigella Phase 2
39
Epinephrine Approved, Vet_approved 51-43-4 5816
40
Racepinephrine Approved 329-65-7 838
41
Lidocaine Approved, Vet_approved 137-58-6 3676
42
Nitric Oxide Approved 10102-43-9 145068
43
Vitamin D Approved, Nutraceutical, Vet_approved 1406-16-2
44
Erythritol Experimental 149-32-6 222285
45 Trace Elements
46 Nutrients
47 Dihydroxycholecalciferols
48 Vitamins
49 Calciferol
50 Micronutrients

Interventional clinical trials:

(show all 50)
# Name Status NCT ID Phase Drugs
1 Efficacy of β-glucan in Treatment of Localized Aggressive Periodontitis: A Short Term Double-blinded, Placebo-controlled, Randomized Clinical Trial Completed NCT02402296 Phase 4 β-1,3/1,6-D-glucan
2 Enamel Matrix Proteins in the Treatment of Intrabony Defects in Patients With Aggressive and Chronic Periodontitis: Randomized Clinical Trial Completed NCT03025204 Phase 4
3 Triclosan as Adjunctive Therapy in the Plaque Control in Children From Generalized Aggressive Periodontitis Families. A Controlled and Randomized Clinical Trial. Completed NCT03642353 Phase 4 Triclosan;Placebo
4 The Use of Amoxicillin and Metronidazole in Association With Non-surgical Therapy in Aggressive Periodontitis Treatment Completed NCT03933501 Phase 4 amoxicillin and metronidazole;Placebos
5 Clinical Evaluation of Systemic Moxifloxacin Compared to Amoxicillin Plus Metronidazole Adjunct to Non-surgical Treatment in Generalized Aggressive Periodontitis: A Randomized Clinical Trial Completed NCT02223702 Phase 4 Amoxicillin;Metronidazole;Moxifloxacin
6 Clinical, Microbiological and Immunological Effects of Antimicrobial Photodynamic Therapy on Non-surgical Treatment of Aggressive Periodontitis: a Double-blind Split-mouth Randomized Controlled Clinical Trial. Completed NCT02049008 Phase 4
7 Evaluation of Gingival Crevicular Fluid Interleukin-1β and Interleukin-17 Levels and Periodontal Pathogens After Full-Mouth Disinfection Initial Periodontal Treatment in Generalized Aggressive Periodontitis Patients Completed NCT02466646 Phase 4 Klorhex® Gel, rinse and spray
8 Adjunctive Systemic Administration of Moxifloxacin in the Treatment of Aggressive Periodontitis: Double-blind Controlled Clinical Trial Completed NCT02125812 Phase 4
9 Efficacy of Moxifloxacin, Amoxicillin+Metronidazole for Aggressive Periodontitis Treatment Active, not recruiting NCT02839421 Phase 4 Scaling and Root Planing combined with moxifloxacin
10 Local Effect of Periodontal Debridement Associated With Different Systemic Antibiotic Protocols and Single or Repeated Application of Photodynamic Therapy to Treat Generalized Aggressive Periodontitis: Randomized Controlled Clinical Trial Completed NCT03132714 Phase 2, Phase 3 Amoxicillin 500mg;Metronidazole 400mg;Clarithromycin 500mg
11 Evaluation of Omega-3 Polyunsaturated Fatty Acids Plus Low-dose Aspirin Daily Supplementation in Non-surgical Therapy to Treat Generalized Aggressive Periodontitis: Randomized Controlled Clinical Trial Completed NCT03093246 Phase 2, Phase 3 Aspirin
12 Full-mouth Periodontal Debridement Associated With Two Different Antibiotic Agents to Treat Generalized Aggressive Periodontitis: Randomized Controlled Clinical Trial Completed NCT02969928 Phase 2, Phase 3 Clarithromycin;Amoxicillin;Metronidazole
13 Evaluation of Omega-3 Polyunsaturated Fatty Acids Plus Low-dose Aspirin Daily Supplementation in Surgical Therapy to Treat Generalized Aggressive Periodontitis: Randomized Controlled Clinical Trial Completed NCT03093207 Phase 2, Phase 3 Aspirin
14 Clinical Effects of Doxycycline in the Treatment of Aggressive Periodontitis: Comparative Clinical Study Completed NCT03727620 Phase 1, Phase 2 amoxicillin plus metronidazole;Doxycycline
15 Nigella Sativa Oil Extract and Xenograft Bone Graft in Treatment of Infra-bony Defects: a Combined Clinical and Histological Study Active, not recruiting NCT04722380 Phase 2
16 Evaluation of the Health of Peri-implant Tissues Around Immediately Placed Dental Implants in Aggressive Periodontitis Patients Versus Periodontally Healthy Individuals in Maxillary Esthetic Zone Unknown status NCT03218228
17 The Affect of Orthodontic Treatment on the Periodontal Status of Patients With Aggressive Periodontitis Unknown status NCT01510808
18 Comparison Between Surgical Access and Repeated Applications of APDT to Residual Pockets Treatment in Generalized Aggressive Periodontitis: Randomized Clinical Trial Unknown status NCT03140059
19 Chronic Presence of Epstein Barr Virus in Epithelial Cells From Gingiva is Associated With Periodontitis Unknown status NCT01246596
20 Clinical and Radiographic Evaluation of Guided Tissue Regeneration With Radiation-sterilized Allogenic Bone Grafts or Xenogenic Grafts for the Treatment of Intrabony Defects in Aggressive Periodontitis: A Randomized Clinical Trial Unknown status NCT03340012
21 Polymorphonuclear Cells' Sensitivity to Aggregatibacter Actinomycetemcomitans Bacteria in Patients With Aggressive Periodontitis Unknown status NCT02010307
22 Evaluation of Active Matrix Metalloproteinase-8 (aMMP-8) Chair-side Test in Different Periodontal Disease and Healthy Implants Completed NCT03527901
23 Clarithromycin as Adjuvant to Periodontal Debridement in the Treatment of Generalized Aggressive Periodontitis: Randomized Clinical Trial Completed NCT02829983 Clarithromycin;Placebo
24 Effect of Non-surgical Periodontal Treatment on GCF HIF-1α, VEGF and TNF-α Levels in Generalized Aggressive Periodontitis Patients. Completed NCT04020315
25 Comparison Of Er,Cr:YSGG and Diode Laser on the Periodontal Parameters and Cytokines Levels in Patients With Generalized Aggressive Periodontitis Completed NCT03034824
26 Comparison of the Physiologic and Biochemical Alterations in the Healthy and Affected Sites of Chronic and Aggressive Periodontitis Patients Completed NCT03625414
27 Immunolocalization of 1,25,Dihydroxyvitamin D3 in Aggressive Periodontitis Patients Completed NCT02282800
28 Metagenomic and Immune-inflammatory Analysis of Individuals With Generalized Aggressive Periodontitis and Their Descendants. Completed NCT03933514
29 Evaluation of the Local Effect of Nonsurgical Periodontal Treatment of Generalized Aggressive Periodontitis Associated or Not With Systemic Antibiotics and Photodynamic Therapy.: a Randomized Clinical Trial Completed NCT03142776 systemic clarithromycin
30 Effects of Smoking on Non-surgical Periodontal Therapy in Generalized Aggressive Periodontitis Completed NCT03512938
31 Gene Expression Profiles in Generalized Aggressive Periodontitis: A Gene Network-based Microarray Analysis Completed NCT02327533
32 The Evaluation of MCP-1 and CCR-2 Gene Polymorphisms Frequency and The Effects of This Polymorphism on Gene Expression in Patients With Aggressive Periodontitis Completed NCT02817568
33 Enamel Matriz Derivate for Treatment of Proximal Class II Furcation Defects: a Randomized Clinical Trial Completed NCT03320135
34 Gingival Crevicular Fluid Levels Of Monocyte Chemoattractant Protein-1 in Patients With Aggressive Periodontitis Completed NCT02927704
35 Clinical And Microbiological Evaluations Of Adjunctive Photodynamic Therapy To Non-Surgical Periodontal Treatment In Patients With Generalized Aggressive Periodontitis Completed NCT03412331
36 Assessment of Pentraxin-3 Levels in Gingival Crevicular Fluid and Saliva in Periodontal Health and Disease Completed NCT03128502
37 Critical Role of Interleukin-34 in Gingival Crevicular Fluid as a Potential Markers of Inflammation in Patients With Periodontitis Completed NCT04223869
38 Effect of Surgical Periodontal Therapy on the RANKL/OPG System : Do we Need Osteo-immune Modulation Targeting RANKL? Completed NCT02190773
39 Interaction Between Immune Cells and Bacteria Associated With Periodontitis Completed NCT03225950
40 Assessment of Nitro - Oxidative Stress in Periodontal Disease Completed NCT02127203
41 Influence of Smoking on Fibroblast Apoptosis in Patients With Chronic and Aggressive Periodontitis Completed NCT02111005
42 Efficacy of Sub-gingival Air-polishing With Erythritol in the Treatment of Periodontitis Completed NCT04264624
43 Subgingival Microbiome Following Mechanical Treatment and it's Effect on Peri-implant Sub-mucosa in Aggressive Periodontitis Patients Recruiting NCT03090282
44 Periodontitis and Inflammation : Biological and Clinical Approach of B Cell Role. Recruiting NCT02833285
45 Pilot Study on Oral Health Status Chairside Mouthrinse Test in Finnish Adolescents and Cost Effectiveness of the Test Active, not recruiting NCT04139863
46 Mechanisms and Treatment Response of Aggressive Periodontitis in Children: Aberrant Immunological Phenotypes/Functions in the Progression of AgP Active, not recruiting NCT01330719
47 Influence of Smoking on Clinical, Microbiological and Immunologic Parameters in Patients With Aggressive Periodontitis Treated With Non-surgical Mechanical Therapy Associated With Systemic Antibiotic Therapy. Active, not recruiting NCT04051255 full mouth ultrassonic debridement associated to Amoxicilin 500 + Metronidazole 400 mg
48 Long-term Results After Systematic Periodontal Therapy Enrolling by invitation NCT03048045
49 Evaluation of Possible Genes in Periodontal Diseases by Genetic Methods Not yet recruiting NCT04026828
50 Analysis of Osteoimmune Interactions Linking Inflammation and Bone Destruction in Aggressive Periodontitis Terminated NCT01993368

Search NIH Clinical Center for Aggressive Periodontitis

Cochrane evidence based reviews: aggressive periodontitis

Genetic Tests for Aggressive Periodontitis

Anatomical Context for Aggressive Periodontitis

MalaCards organs/tissues related to Aggressive Periodontitis:

40
Neutrophil, Bone, Monocytes, Myeloid, Whole Blood, T Cells, Endothelial

Publications for Aggressive Periodontitis

Articles related to Aggressive Periodontitis:

(show top 50) (show all 1633)
# Title Authors PMID Year
1
The role of cathepsin C in Papillon-Lefèvre syndrome, prepubertal periodontitis, and aggressive periodontitis. 6 61
14974080 2004
2
Autophagic dysfunction in patients with Papillon-Lefèvre syndrome is restored by recombinant cathepsin C treatment. 6
29410039 2018
3
[Papillon-Lefèvre syndrome: A new case]. 6
28242153 2017
4
Identification of novel mutation in cathepsin C gene causing Papillon-Lefèvre Syndrome in Mexican patients. 6
23311634 2013
5
Biochemical and mutational analyses of the cathepsin c gene (CTSC) in three North American families with Papillon Lefèvre syndrome. 6
12112662 2002
6
Novel point mutations, deletions, and polymorphisms in the cathepsin C gene in nine families from Europe and North Africa with Papillon-Lefèvre syndrome. 6
11886537 2001
7
Papillon-Lefèvre syndrome: mutations and polymorphisms in the cathepsin C gene. 6
11180012 2001
8
Localisation of a gene for prepubertal periodontitis to chromosome 11q14 and identification of a cathepsin C gene mutation. 6
10662808 2000
9
Loss-of-function mutations in the cathepsin C gene result in periodontal disease and palmoplantar keratosis. 6
10581027 1999
10
Mutations of the cathepsin C gene are responsible for Papillon-Lefèvre syndrome. 6
10593994 1999
11
Quantification of glial fibrillary acidic protein: comparison of slot-immunobinding assays with a novel sandwich ELISA. 6
1886537 1991
12
Etiology of aggressive periodontitis in individuals of African descent. 61
33737991 2021
13
Hyperresponsiveness of human gingival fibroblasts from patients with aggressive periodontitis against bacterial lipopolysaccharide. 61
33747158 2021
14
Effectiveness of antimicrobial photodynamic therapy as an adjunct to open flap debridement in patients with aggressive periodontitis. 61
33157325 2021
15
Genome-wide association study of stage III/IV grade C periodontitis (former aggressive periodontitis) in a Spanish population. 61
33745150 2021
16
Association of IL-10 -1082A>G, -819C>T, and -592C>A polymorphisms with susceptibility to chronic and aggressive periodontitis: a systematic review and meta-analysis. 61
33666703 2021
17
Pro-inflammatory cytokine interleukin-6-induced hepcidin, a key mediator of periodontitis-related anemia of inflammation. 61
33656216 2021
18
A Case of Mandibular Prognathism with Generalized Aggressive Periodontitis and Crowding. 61
33583878 2021
19
Preliminary functional analysis of the subgingival microbiota of cats with periodontitis and feline chronic gingivostomatitis. 61
33767308 2021
20
Expression of virulence factors under different environmental conditions in Aggregatibacter actinomycetemcomitans. 61
33591576 2021
21
Antibiotic Use in Periodontal Therapy among French Dentists and Factors Which Influence Prescribing Practices. 61
33804145 2021
22
Treatment of localized aggressive periodontitis alters local host immunoinflammatory profiles: A long-term evaluation. 61
33205510 2021
23
Cognitive dysfunction in young subjects with periodontal disease. 61
33606127 2021
24
Idiopathic gingival fibromatosis in association with aggressive periodontitis and candidal infection: A unique case report with 7-year follow-up. 61
33642744 2021
25
The impact of supportive periodontal treatment on the outcome of regenerative surgical therapy in aggressive periodontitis patients. 61
33491386 2021
26
Antibiotics against Periodontal Biofilms. 61
33427226 2021
27
Evaluation of the Virulence of Aggregatibacter actinomycetemcomitans Through the Analysis of Leukotoxin. 61
32815139 2021
28
Parents with periodontitis impact the subgingival colonization of their offspring. 61
33446688 2021
29
Surgical Treatment of Furcation Involvement Associated with Recurrence of Aggressive Periodontitis: A Case Report. 61
33177273 2020
30
Detection of association between periodontitis and polymorphisms of IL-1β + 3954 and TNF-α -863 in the Korean population after controlling for confounding risk factors. 61
32618013 2020
31
[Association between root abnormalities and related pathogenic genes in patients with generalized aggressive periodontitis]. 61
33550331 2020
32
Role of Aggregatibacter actinomycetemcomitans-induced autophagy in inflammatory response. 61
32170963 2020
33
Local delivery therapies as adjuvants to non-surgical periodontal treatment of periodontitis grade C: a systematic review. 61
33070281 2020
34
Effect of non-surgical periodontal treatment on gingival crevicular fluid hypoxia inducible factor-1 alpha, vascular endothelial growth factor and tumor necrosis factor-alpha levels in generalized aggressive periodontitis patients. 61
32246842 2020
35
Dysregulation of genes and microRNAs in localized aggressive periodontitis. 61
32876337 2020
36
Application of weighted gene co-expression network analysis to reveal key modules and hub genes in generalized aggressive periodontitis. 61
32916454 2020
37
Adjunctive systemic antimicrobials for the non-surgical treatment of periodontitis. 61
33197289 2020
38
Association of Polymorphism in IL-18 Gene with Periodontitis in Uyghur Adults in Xinjiang and Evidence from Six Case-Control Studies with a Comprehensive Analysis. 61
33143466 2020
39
The familial trend of the local inflammatory response in periodontal disease. 61
33252790 2020
40
Clinical, radiographic and patient-centered outcomes after use of enamel matrix proteins for the treatment of intrabony defects in patients with aggressive periodontitis: A 12-month multicenter clinical trial. 61
33107596 2020
41
Aggressive periodontitis and NOD2 variants. 61
32424308 2020
42
Africa and South America seem to have the highest prevalence of aggressive periodontitis, and Europe has the lowest. 61
32736798 2020
43
Differential expression of microRNAs in the saliva of patients with aggressive periodontitis: a pilot study of potential biomarkers for aggressive periodontitis. 61
33124206 2020
44
Regenerative therapies may result in a larger reduction in probing depth of periodontal bony defects due to aggressive periodontitis after 6 months. 61
32709303 2020
45
Metronidazole and amoxicillin association in aggressive periodontitis: A systematic review and meta-analysis. 61
32874066 2020
46
Elevated neutrophil-to-lymphocyte ratio but not platelet-to-lymphocyte ratio is associated with generalized aggressive periodontitis in a Chinese population. 61
32909291 2020
47
Effects of xipayi mouth rinse combined with minocycline on localized aggressive periodontitis' therapeutic effect and the levels of CRP, TNF-α, IL-6 in serum. 61
33065791 2020
48
The Association Between Some Macro and Trace Elements in Saliva and Periodontal Status. 61
31848920 2020
49
Association of oral health-related quality of life measures with aggressive and chronic periodontitis. 61
32232983 2020
50
Salivary Del-1, IL-17, and LFA-1 levels in periodontal health and disease. 61
32153040 2020

Variations for Aggressive Periodontitis

ClinVar genetic disease variations for Aggressive Periodontitis:

6 (show top 50) (show all 67)
# Gene Name Type Significance ClinVarId dbSNP ID Position
1 CTSC NM_001814.6(CTSC):c.1235A>G (p.Tyr412Cys) SNV Pathogenic 7300 rs28937571 GRCh37: 11:88027331-88027331
GRCh38: 11:88294163-88294163
2 CTSC NM_001814.6(CTSC):c.1040A>G (p.Tyr347Cys) SNV Pathogenic 7301 rs104894211 GRCh37: 11:88027526-88027526
GRCh38: 11:88294358-88294358
3 CTSC NM_001814.6(CTSC):c.815G>A (p.Arg272His) SNV Pathogenic 139656 rs587777534 GRCh37: 11:88029375-88029375
GRCh38: 11:88296207-88296207
4 CTSC NM_001814.6(CTSC):c.628C>T (p.Arg210Ter) SNV Pathogenic 7289 GRCh37: 11:88042344-88042344
GRCh38: 11:88309176-88309176
5 CTSC NM_001814.6(CTSC):c.203T>G (p.Leu68Arg) SNV Pathogenic 839668 GRCh37: 11:88068220-88068220
GRCh38: 11:88335052-88335052
6 CTSC NM_001814.6(CTSC):c.96T>G (p.Tyr32Ter) SNV Pathogenic 139655 GRCh37: 11:88070745-88070745
GRCh38: 11:88337577-88337577
7 CTSC NM_001814.6(CTSC):c.1096del (p.His366fs) Deletion Pathogenic 935708 GRCh37: 11:88027470-88027470
GRCh38: 11:88294302-88294302
8 CTSC NM_001814.6(CTSC):c.901G>A (p.Gly301Ser) SNV Pathogenic 7297 GRCh37: 11:88027665-88027665
GRCh38: 11:88294497-88294497
9 CTSC NM_001814.6(CTSC):c.815G>C (p.Arg272Pro) SNV Likely pathogenic 548504 rs587777534 GRCh37: 11:88029375-88029375
GRCh38: 11:88296207-88296207
10 CTSC NM_001814.6(CTSC):c.855dup (p.Gln286fs) Duplication Likely pathogenic 575092 GRCh37: 11:88029334-88029335
GRCh38: 11:88296166-88296167
11 CTSC NM_001814.6(CTSC):c.790A>C (p.Met264Leu) SNV Uncertain significance 575218 GRCh37: 11:88029400-88029400
GRCh38: 11:88296232-88296232
12 CTSC NM_001814.6(CTSC):c.1194C>A (p.Asn398Lys) SNV Uncertain significance 640536 GRCh37: 11:88027372-88027372
GRCh38: 11:88294204-88294204
13 CTSC NM_001814.6(CTSC):c.1303G>A (p.Glu435Lys) SNV Uncertain significance 643044 GRCh37: 11:88027263-88027263
GRCh38: 11:88294095-88294095
14 CTSC NM_001814.6(CTSC):c.395G>A (p.Arg132Gln) SNV Uncertain significance 646118 GRCh37: 11:88045646-88045646
GRCh38: 11:88312478-88312478
15 CTSC NM_001814.6(CTSC):c.1201G>A (p.Glu401Lys) SNV Uncertain significance 647363 GRCh37: 11:88027365-88027365
GRCh38: 11:88294197-88294197
16 CTSC NM_001814.6(CTSC):c.790A>G (p.Met264Val) SNV Uncertain significance 647418 GRCh37: 11:88029400-88029400
GRCh38: 11:88296232-88296232
17 CTSC NM_001814.6(CTSC):c.259A>G (p.Ile87Val) SNV Uncertain significance 548698 rs45447392 GRCh37: 11:88068164-88068164
GRCh38: 11:88334996-88334996
18 CTSC NM_001814.6(CTSC):c.364A>G (p.Met122Val) SNV Uncertain significance 648150 GRCh37: 11:88045677-88045677
GRCh38: 11:88312509-88312509
19 CTSC NM_001814.6(CTSC):c.1392G>A (p.Ter464=) SNV Uncertain significance 650803 GRCh37: 11:88027174-88027174
GRCh38: 11:88294006-88294006
20 CTSC NM_001814.6(CTSC):c.910T>A (p.Tyr304Asn) SNV Uncertain significance 651983 GRCh37: 11:88027656-88027656
GRCh38: 11:88294488-88294488
21 CTSC NM_001814.6(CTSC):c.757+5A>G SNV Uncertain significance 652502 GRCh37: 11:88033693-88033693
GRCh38: 11:88300525-88300525
22 CTSC NM_001814.6(CTSC):c.953A>G (p.Glu318Gly) SNV Uncertain significance 652504 GRCh37: 11:88027613-88027613
GRCh38: 11:88294445-88294445
23 CTSC NM_001814.6(CTSC):c.1345G>A (p.Ala449Thr) SNV Uncertain significance 654717 GRCh37: 11:88027221-88027221
GRCh38: 11:88294053-88294053
24 CTSC NM_001814.6(CTSC):c.37C>A (p.Leu13Met) SNV Uncertain significance 659313 GRCh37: 11:88070804-88070804
GRCh38: 11:88337636-88337636
25 CTSC NM_001814.6(CTSC):c.923G>A (p.Gly308Glu) SNV Uncertain significance 665835 GRCh37: 11:88027643-88027643
GRCh38: 11:88294475-88294475
26 CTSC NM_001814.6(CTSC):c.907C>T (p.Pro303Ser) SNV Uncertain significance 853063 GRCh37: 11:88027659-88027659
GRCh38: 11:88294491-88294491
27 CTSC NM_001814.6(CTSC):c.71G>A (p.Cys24Tyr) SNV Uncertain significance 534587 GRCh37: 11:88070770-88070770
GRCh38: 11:88337602-88337602
28 CTSC NM_001814.6(CTSC):c.1289G>A (p.Gly430Asp) SNV Uncertain significance 534588 GRCh37: 11:88027277-88027277
GRCh38: 11:88294109-88294109
29 CTSC NM_001814.6(CTSC):c.844A>G (p.Ile282Val) SNV Uncertain significance 534589 GRCh37: 11:88029346-88029346
GRCh38: 11:88296178-88296178
30 CTSC NM_001814.6(CTSC):c.295T>C (p.Tyr99His) SNV Uncertain significance 568193 GRCh37: 11:88068128-88068128
GRCh38: 11:88334960-88334960
31 CTSC NM_001814.6(CTSC):c.550T>C (p.Ser184Pro) SNV Uncertain significance 1047420 GRCh37: 11:88042422-88042422
GRCh38: 11:88309254-88309254
32 CTSC NC_000011.10:g.(?_88293986)_(88337727_?)dup Duplication Uncertain significance 830637 GRCh37: 11:88027154-88070895
GRCh38:
33 CTSC NM_001814.6(CTSC):c.1169A>G (p.His390Arg) SNV Uncertain significance 834209 GRCh37: 11:88027397-88027397
GRCh38: 11:88294229-88294229
34 CTSC NM_001814.6(CTSC):c.919G>A (p.Ala307Thr) SNV Uncertain significance 943207 GRCh37: 11:88027647-88027647
GRCh38: 11:88294479-88294479
35 CTSC NM_001814.6(CTSC):c.796A>G (p.Met266Val) SNV Uncertain significance 944290 GRCh37: 11:88029394-88029394
GRCh38: 11:88296226-88296226
36 CTSC NM_001814.6(CTSC):c.299A>G (p.Lys100Arg) SNV Uncertain significance 466227 GRCh37: 11:88068124-88068124
GRCh38: 11:88334956-88334956
37 CTSC NM_001814.6(CTSC):c.29C>T (p.Ala10Val) SNV Uncertain significance 306432 rs765499436 GRCh37: 11:88070812-88070812
GRCh38: 11:88337644-88337644
38 CTSC NM_001814.6(CTSC):c.308C>T (p.Ala103Val) SNV Uncertain significance 650523 GRCh37: 11:88068115-88068115
GRCh38: 11:88334947-88334947
39 CTSC NM_001814.6(CTSC):c.1294G>A (p.Gly432Ser) SNV Uncertain significance 836452 GRCh37: 11:88027272-88027272
GRCh38: 11:88294104-88294104
40 CTSC NM_001814.6(CTSC):c.893G>A (p.Cys298Tyr) SNV Uncertain significance 851663 GRCh37: 11:88027673-88027673
GRCh38: 11:88294505-88294505
41 CTSC NM_001814.6(CTSC):c.1346C>T (p.Ala449Val) SNV Uncertain significance 851940 GRCh37: 11:88027220-88027220
GRCh38: 11:88294052-88294052
42 CTSC NM_001814.6(CTSC):c.1194C>G (p.Asn398Lys) SNV Uncertain significance 306418 rs201519830 GRCh37: 11:88027372-88027372
GRCh38: 11:88294204-88294204
43 CTSC NM_001814.6(CTSC):c.358G>A (p.Glu120Lys) SNV Uncertain significance 856793 GRCh37: 11:88045683-88045683
GRCh38: 11:88312515-88312515
44 CTSC NM_001814.6(CTSC):c.1084C>G (p.Leu362Val) SNV Uncertain significance 1009025 GRCh37: 11:88027482-88027482
GRCh38: 11:88294314-88294314
45 CTSC NM_001814.6(CTSC):c.574G>C (p.Glu192Gln) SNV Uncertain significance 1012119 GRCh37: 11:88042398-88042398
GRCh38: 11:88309230-88309230
46 CTSC NM_001814.6(CTSC):c.338A>G (p.Lys113Arg) SNV Uncertain significance 849347 GRCh37: 11:88045703-88045703
GRCh38: 11:88312535-88312535
47 CTSC NM_001814.6(CTSC):c.1159A>T (p.Ile387Phe) SNV Uncertain significance 953826 GRCh37: 11:88027407-88027407
GRCh38: 11:88294239-88294239
48 CTSC NM_001814.6(CTSC):c.318+4_318+7del Deletion Uncertain significance 1019816 GRCh37: 11:88068098-88068101
GRCh38: 11:88334930-88334933
49 CTSC NM_001814.6(CTSC):c.1121T>C (p.Phe374Ser) SNV Uncertain significance 1021975 GRCh37: 11:88027445-88027445
GRCh38: 11:88294277-88294277
50 CTSC NM_001814.6(CTSC):c.1325G>A (p.Arg442His) SNV Uncertain significance 647623 GRCh37: 11:88027241-88027241
GRCh38: 11:88294073-88294073

Expression for Aggressive Periodontitis

Search GEO for disease gene expression data for Aggressive Periodontitis.

Pathways for Aggressive Periodontitis

Pathways related to Aggressive Periodontitis according to GeneCards Suite gene sharing:

(show top 50) (show all 72)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14.07 TNFSF11 TNF TLR4 TLR2 MMP8 MMP1
2
Show member pathways
13.76 TNFSF11 TNF TLR4 IL6 IL4 IL1RN
3
Show member pathways
13.52 TNFSF11 TNF TLR4 TLR2 IL6 IL4
4
Show member pathways
13.47 TNFSF11 TNF MMP1 IL6 IL4 IL1RN
5
Show member pathways
13.39 TNFSF11 TNF IL6 IL4 IL1B IL1A
6
Show member pathways
13.3 TNF TLR4 TLR2 MMP1 IL6 IL1B
7
Show member pathways
13.01 TNF TLR4 TLR2 IL6 IL1B CXCL8
8
Show member pathways
12.98 TNF IL6 IL4 IL1B IL1A IL10
9
Show member pathways
12.95 TNF TLR4 TLR2 IL6 IL1B IL1A
10
Show member pathways
12.87 TNF TLR4 TLR2 IL6 IL1B FCGR2A
11
Show member pathways
12.86 TNF TLR4 TLR2 IL6 IL1RN IL1B
12
Show member pathways
12.81 TNF TLR4 TLR2 IL6 IL1B IL1A
13
Show member pathways
12.75 TNF TLR4 TLR2 IL6 IL4 IL1B
14
Show member pathways
12.74 TNF TLR4 TLR2 IL6 IL4 IL1B
15
Show member pathways
12.71 TNFSF11 TNF TLR4 TLR2 IL1B IL1A
16 12.69 TNFSF11 TNF TLR2 IL4 IL1RN IL1B
17
Show member pathways
12.49 TNF TLR2 MMP1 IL6 IL4 IL1B
18
Show member pathways
12.46 TNF TLR4 IL6 IL1B IL1A CXCL8
19 12.44 TNF TLR4 IL1B CXCL8
20
Show member pathways
12.4 TNF TLR4 TLR2 IL6 IL1A CXCL8
21
Show member pathways
12.4 TNF IL6 IL4 IL1B IL1A IL10
22
Show member pathways
12.38 TNF IL6 IL10 CXCL8
23
Show member pathways
12.38 TNF IL6 IL4 IL1B
24
Show member pathways
12.37 TNF TLR4 TLR2 IL4 IL1B IL1A
25 12.36 TNF TLR4 IL6 IL1B CXCL8
26
Show member pathways
12.35 TNF TLR4 TLR2 IL6 IL4 IL1B
27 12.34 TNF IL6 IL1RN IL1B IL1A IL10
28 12.32 TNF TLR4 TLR2 MMP1 IL6
29
Show member pathways
12.28 TNF IL6 IL1B IL10
30
Show member pathways
12.27 TNF TLR4 IL1B IL1A
31 12.25 TNF TLR4 IL6 IL1B IL10 FCGR2A
32 12.19 TNFSF11 TNF IL1B IL1A FCGR2A
33 12.14 TNF IL6 IL4 IL10 FCGR2A
34
Show member pathways
12.12 TLR4 TLR2 IL1B IL1A
35 12.08 TNFSF11 TNF TLR4 IL1B CXCL8
36 12.08 TNF TLR4 TLR2 IL6 IL1B IL10
37 12.06 TNF IL6 IL1B IL1A CXCL8
38 12.06 VDR TNF TLR4 TLR2 IL6 IL1B
39 12.05 IL6 IL1B IL1A CXCL8
40 12.05 TNF IL6 IL4 IL1B IL1A
41 12.05 TNF TLR4 IL6 IL4 IL1B IL1A
42
Show member pathways
12.01 TLR4 TLR2 IL6 IL4 IL1B
43 12 IL10 FPR1 FCGR2A DEFB1
44 11.98 TNF MMP1 IL6 IL4 IL1B IL1A
45 11.93 MMP1 IL6 IL4 CXCL8
46
Show member pathways
11.93 TNF TLR4 TLR2 IL6 IL1B IL10
47 11.91 TNF IL4 IL1B IL10
48 11.88 TNF IL6 IL1B IL10
49 11.88 TNF TLR4 IL6 IL1B IL1A IL10
50 11.83 TNF IL6 IL4 IL1B CXCL8

GO Terms for Aggressive Periodontitis

Cellular components related to Aggressive Periodontitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.77 TNFSF11 TNF MMP8 MMP1 IL6 IL4
2 extracellular space GO:0005615 9.4 TNFSF11 TNF MMP8 IL6 IL4 IL1RN

Biological processes related to Aggressive Periodontitis according to GeneCards Suite gene sharing:

(show top 50) (show all 65)
# Name GO ID Score Top Affiliating Genes
1 signal transduction GO:0007165 10.35 TLR4 TLR2 IL6 IL4 IL1RN IL1B
2 positive regulation of transcription by RNA polymerase II GO:0045944 10.24 VDR TNFSF11 TNF TLR4 TLR2 IL6
3 neutrophil degranulation GO:0043312 10.12 TLR2 MMP8 FPR1 FCGR2A CTSC
4 negative regulation of cell proliferation GO:0008285 10.12 VDR TLR2 IL6 IL1B IL1A IL10
5 response to lipopolysaccharide GO:0032496 10 TLR4 TLR2 IL1B IL10
6 inflammatory response GO:0006954 9.97 TNF TLR4 TLR2 IL6 IL1RN IL1B
7 activation of MAPK activity GO:0000187 9.96 TNF TLR4 IL1B FPR1
8 positive regulation of DNA-binding transcription factor activity GO:0051091 9.96 TNFSF11 TNF IL6 IL1B IL10
9 defense response to Gram-positive bacterium GO:0050830 9.95 TNF TLR2 IL6 DEFB1
10 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.95 TNFSF11 TNF TLR4 TLR2 IL6 IL1B
11 positive regulation of inflammatory response GO:0050729 9.93 TNF TLR4 TLR2 IL1B
12 response to glucocorticoid GO:0051384 9.91 TNF IL6 IL1RN IL10
13 positive regulation of tumor necrosis factor production GO:0032760 9.91 TLR4 TLR2 MMP8 IL6 IL1A
14 cellular response to lipopolysaccharide GO:0071222 9.91 TNF TLR4 IL6 IL1B IL1A IL10
15 negative regulation of tumor necrosis factor production GO:0032720 9.9 TLR4 IL4 IL10
16 regulation of insulin secretion GO:0050796 9.9 TNF IL6 IL1B
17 negative regulation of interleukin-6 production GO:0032715 9.9 TNF TLR4 IL10
18 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.9 TNF IL6 IL4
19 positive regulation of gene expression GO:0010628 9.9 VDR TNFSF11 TNF TLR4 TLR2 MMP8
20 positive regulation of interferon-gamma production GO:0032729 9.89 TNF TLR4 IL1B
21 positive regulation of T cell proliferation GO:0042102 9.89 IL6 IL4 IL1B
22 positive regulation of JNK cascade GO:0046330 9.89 TNFSF11 TNF TLR4 MMP8 IL1B
23 positive regulation of interleukin-1 beta production GO:0032731 9.88 TNF TLR4 IL6
24 positive regulation of cytokine production GO:0001819 9.88 TNF IL1A IL10
25 positive regulation of nitric oxide biosynthetic process GO:0045429 9.88 TNF TLR4 MMP8 IL1B
26 positive regulation of chemokine production GO:0032722 9.87 TNF TLR4 TLR2 IL6
27 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001240 9.85 TNF IL1B IL1A
28 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.85 TNF TLR4 TLR2 MMP8 IL1B
29 positive regulation of interleukin-10 production GO:0032733 9.84 TLR4 TLR2 IL6 IL4
30 positive regulation of JAK-STAT cascade GO:0046427 9.83 TNF IL6 IL10
31 microglial cell activation GO:0001774 9.83 TNF TLR2 IL4
32 positive regulation of vascular endothelial growth factor production GO:0010575 9.83 IL6 IL1B IL1A
33 lipopolysaccharide-mediated signaling pathway GO:0031663 9.83 TNF TLR4 TLR2 IL1B
34 positive regulation of interleukin-8 production GO:0032757 9.83 TNF TLR4 TLR2 IL6 IL1B
35 negative regulation of neurogenesis GO:0050768 9.81 TNF IL6 IL1B
36 positive regulation of cytokine production involved in inflammatory response GO:1900017 9.81 TNF TLR4 IL6
37 positive regulation of glial cell proliferation GO:0060252 9.8 TNF IL6 IL1B
38 positive regulation of interleukin-6 production GO:0032755 9.8 TNF TLR4 TLR2 MMP8 IL6 IL1B
39 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.79 TNF IL1B IL10
40 positive regulation of MHC class II biosynthetic process GO:0045348 9.78 TLR4 IL4 IL10
41 response to molecule of bacterial origin GO:0002237 9.77 TLR2 IL10 CXCL8
42 regulation of neuroinflammatory response GO:0150077 9.74 MMP8 IL6
43 negative regulation of heterotypic cell-cell adhesion GO:0034115 9.73 IL1RN IL10
44 positive regulation of chemokine (C-X-C motif) ligand 2 production GO:2000343 9.73 TNF TLR4
45 regulation of establishment of endothelial barrier GO:1903140 9.73 TNF IL1B
46 cellular response to lipoteichoic acid GO:0071223 9.73 TLR4 TLR2
47 negative regulation of lipid storage GO:0010888 9.72 TNF IL6
48 endothelial cell apoptotic process GO:0072577 9.72 TNF IL10
49 vascular endothelial growth factor production GO:0010573 9.72 TNF IL6 IL1B
50 negative regulation of interleukin-1-mediated signaling pathway GO:2000660 9.71 IL6 IL1RN

Molecular functions related to Aggressive Periodontitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.28 TNFSF11 TNF IL6 IL4 IL1RN IL1B
2 lipopolysaccharide receptor activity GO:0001875 9.16 TLR4 TLR2
3 interleukin-1 receptor binding GO:0005149 9.13 IL1RN IL1B IL1A

Sources for Aggressive Periodontitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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