MCID: AGG001
MIFTS: 55

Aggressive Periodontitis

Categories: Bone diseases, Genetic diseases, Oral diseases

Aliases & Classifications for Aggressive Periodontitis

MalaCards integrated aliases for Aggressive Periodontitis:

Name: Aggressive Periodontitis 12 45 15 17
Periodontitis, Juvenile 74
Juvenile Periodontitis 12

Classifications:



External Ids:

Disease Ontology 12 DOID:1474
MeSH 45 D010520
SNOMED-CT 69 2624008 49965002
ICD10 34 K05.2
UMLS 74 C0031106

Summaries for Aggressive Periodontitis

Disease Ontology : 12 A periodontitis that is characterized by rapid attachment loss and bone destruction in the presence of little local factors such as dental plaque and dental calculus resulting in inflammation and a loss of periodontium.

MalaCards based summary : Aggressive Periodontitis, also known as periodontitis, juvenile, is related to periodontitis, chronic and juvenile rheumatoid arthritis. An important gene associated with Aggressive Periodontitis is PDON2 (Periodontitis, Localized Aggressive), and among its related pathways/superpathways are Innate Immune System and PEDF Induced Signaling. The drugs Estradiol and Metronidazole have been mentioned in the context of this disorder. Affiliated tissues include bone, neutrophil and monocytes, and related phenotypes are hematopoietic system and homeostasis/metabolism

Wikipedia : 77 Aggressive periodontitis describes a type of periodontal disease and includes two of the seven... more...

Related Diseases for Aggressive Periodontitis

Diseases in the Aggressive Periodontitis family:

Periodontitis, Aggressive, 1 Periodontitis, Aggressive, 2

Diseases related to Aggressive Periodontitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 343)
# Related Disease Score Top Affiliating Genes
1 periodontitis, chronic 32.0 IL1B IL6 MMP8 TNFSF11
2 juvenile rheumatoid arthritis 30.2 IL1B IL1RN IL6 TNF
3 diabetes mellitus 30.2 IL1A IL1B IL1RN IL6 TNF
4 spondylitis 30.0 IL1RN IL6 TNF
5 gingivitis 29.7 CXCL8 IL1A IL1B IL4 IL6 MMP8
6 endocarditis 29.5 CXCL8 FCGR2A IL10 IL6 TNF
7 periodontosis 29.3 CXCL8 TLR4 TNF TNFSF11
8 arthritis 29.0 CXCL8 IL10 IL1A IL1B IL1RN IL6
9 bacterial infectious disease 28.9 CXCL8 FPR1 IL10 IL1B IL6 TLR4
10 periodontitis 28.5 CTSC CXCL8 FPR1 IL10 IL1A IL1B
11 periodontal disease 28.2 CTSC CXCL8 IL1A IL1B IL1RN IL6
12 rheumatoid arthritis 28.0 CXCL8 IL10 IL1A IL1B IL1RN IL4
13 susceptibility to localized juvenile periodontitis 12.2
14 periodontitis, aggressive, 1 11.6
15 papillon-lefevre syndrome 11.5
16 chronic follicular conjunctivitis 10.6 IL1A IL1B
17 kashin-beck disease 10.5 IL1B TNF
18 skin conditions 10.5 IL1A TNF
19 staphylococcal toxic shock syndrome 10.5 IL1B TNF
20 transient hypogammaglobulinemia 10.5 IL10 TNF
21 scleral disease 10.5 IL1RN TNF
22 multifocal choroiditis 10.5 IL10 TNF
23 angioimmunoblastic lymphadenopathy with dysproteinemia 10.5 IL6 TNF
24 punctate inner choroidopathy 10.5 IL10 TNF
25 critical limb ischemia 10.5 IL6 TNF
26 pustulosis of palm and sole 10.5 IL1RN TNF
27 autoimmune myocarditis 10.5 IL6 TNF
28 leukomalacia 10.5 IL6 TNF
29 scorpion envenomation 10.5 IL6 TNF
30 cardiogenic shock 10.5 IL6 TNF
31 eye lymphoma 10.5 IL10 IL6
32 acute cholangitis 10.5 IL1RN IL6
33 autoimmune vasculitis 10.5 IL1B IL4
34 cryopyrin-associated periodic syndrome 10.5 IL1RN IL6
35 congenital hypogammaglobulinemia 10.5 IL1A IL4
36 nickel allergic contact dermatitis 10.5 IL10 IL4
37 hyperlucent lung 10.5 IL10 IL4
38 b-cell growth factor 10.5 IL4 IL6
39 leukoregulin 10.4 CXCL8 IL1A
40 vulvovaginitis 10.4 CXCL8 IL10
41 neurosyphilis 10.4 CXCL8 IL10
42 familial mediterranean fever 10.4 IL1B IL1RN TNF
43 rheumatic disease 10.4 IL10 IL1B TNF
44 demyelinating disease 10.4 IL10 IL1B TNF
45 arteries, anomalies of 10.4 IL1B IL6 TNF
46 extrapulmonary tuberculosis 10.4 IL10 IL1B IL1RN
47 chikungunya 10.4 IL1B IL6 TNF
48 acquired metabolic disease 10.4 IL1B IL6 TNF
49 endometritis 10.4 IL1B IL6 TNF
50 lyme disease 10.4 IL1B IL6 TNF

Graphical network of the top 20 diseases related to Aggressive Periodontitis:



Diseases related to Aggressive Periodontitis

Symptoms & Phenotypes for Aggressive Periodontitis

MGI Mouse Phenotypes related to Aggressive Periodontitis:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.28 CTSC FCGR2A FCGR3B FPR1 IL10 IL1A
2 homeostasis/metabolism MP:0005376 10.25 CTSC FCGR3B FPR1 IL10 IL1A IL1B
3 immune system MP:0005387 10.24 CTSC FCGR2A FCGR3B FPR1 IL10 IL1A
4 integument MP:0010771 10.06 CTSC IL10 IL1A IL1B IL1RN IL4
5 mortality/aging MP:0010768 10 FCGR2A FPR1 IL10 IL1B IL1RN IL4
6 neoplasm MP:0002006 9.76 IL10 IL1A IL1B IL6 MMP8 TLR4
7 reproductive system MP:0005389 9.56 IL10 IL1RN IL4 IL6 TLR4 TNF
8 skeleton MP:0005390 9.36 FCGR2A FCGR3B IL10 IL1B IL1RN IL4

Drugs & Therapeutics for Aggressive Periodontitis

Drugs for Aggressive Periodontitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 79)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Estradiol Approved, Investigational, Vet_approved Phase 4 50-28-2 5757
2
Metronidazole Approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 443-48-1 4173
3
Moxifloxacin Approved, Investigational Phase 4 354812-41-2, 151096-09-2 152946
4
Norgestimate Approved, Investigational Phase 4 35189-28-7 6540478
5
Polyestradiol phosphate Approved Phase 4 28014-46-2
6
Ethinyl Estradiol Approved Phase 4 57-63-6 5991
7
Amoxicillin Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 26787-78-0 33613
8
Chlorhexidine Approved, Vet_approved Phase 4 55-56-1 2713 9552079
9
Triclosan Approved, Investigational Phase 4 3380-34-5 5564
10 sodium fluoride Approved Phase 4 7681-49-4
11 Antiparasitic Agents Phase 4,Phase 2,Phase 3,Phase 1
12 Contraceptives, Oral Phase 4
13 Anesthetics Phase 4,Not Applicable
14 Estradiol 17 beta-cypionate Phase 4
15 Antiprotozoal Agents Phase 4,Phase 2,Phase 3,Phase 1
16 Contraceptives, Oral, Combined Phase 4
17 Contraceptive Agents Phase 4
18 Anti-Infective Agents Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
19 Topoisomerase Inhibitors Phase 4
20 Norgestimate, ethinyl estradiol drug combination Phase 4
21 Anti-Bacterial Agents Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
22 Antibiotics, Antitubercular Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
23 Estradiol 3-benzoate Phase 4
24 Chlorhexidine gluconate Phase 4
25 Listerine Phase 4
26 Anti-Infective Agents, Local Phase 4
27 Fluorides Phase 4
28 Hypolipidemic Agents Phase 4
29 Cariostatic Agents Phase 4
30 Antimetabolites Phase 4
31 Lipid Regulating Agents Phase 4
32 Protective Agents Phase 4
33 Anesthetics, Local Phase 4
34
Aspirin Approved, Vet_approved Phase 2, Phase 3,Phase 3 50-78-2 2244
35
Clarithromycin Approved Phase 2, Phase 3,Phase 3,Not Applicable 81103-11-9 84029
36 Analgesics Phase 2, Phase 3,Phase 3
37 Anti-Inflammatory Agents, Non-Steroidal Phase 2, Phase 3,Phase 3
38 Analgesics, Non-Narcotic Phase 2, Phase 3,Phase 3
39 Cyclooxygenase Inhibitors Phase 2, Phase 3,Phase 3
40 Fibrinolytic Agents Phase 2, Phase 3,Phase 3
41 Antipyretics Phase 2, Phase 3,Phase 3
42 Anti-Inflammatory Agents Phase 2, Phase 3,Phase 3
43 Omega 3 Fatty Acid Phase 2, Phase 3,Phase 3
44 Peripheral Nervous System Agents Phase 2, Phase 3,Phase 3
45 Platelet Aggregation Inhibitors Phase 2, Phase 3,Phase 3
46 Antirheumatic Agents Phase 2, Phase 3,Phase 3
47 Cytochrome P-450 Enzyme Inhibitors Phase 2, Phase 3,Phase 3,Not Applicable
48 Cytochrome P-450 CYP3A Inhibitors Phase 2, Phase 3,Phase 3,Not Applicable
49
Doxycycline Approved, Investigational, Vet_approved Phase 1, Phase 2 564-25-0 54671203
50 Antimalarials Phase 1, Phase 2

Interventional clinical trials:

(show all 48)
# Name Status NCT ID Phase Drugs
1 Efficacy of Three Antibiotic Protocols for Aggressive Periodontitis Treatment Unknown status NCT02839421 Phase 4 Scaling and Root Planing combined with moxifloxacin
2 Adjunctive Systemic Administration of Moxifloxacin in the Treatment of Aggressive Periodontitis Completed NCT02125812 Phase 4
3 Amoxicillin and Metronidazole in Association With Non-surgical Therapy in Aggressive Periodontitis Treatment Completed NCT03933501 Phase 4 amoxicillin and metronidazole;Placebos
4 Evaluation of Efficacy of Full-mouth Disinfection in Generalized Aggressive Periodontitis Patients Completed NCT02466646 Phase 4 Klorhex® Gel, rinse and sprey
5 Triclosan as Adjunctive Therapy in the Plaque Control in Children From Generalized Aggressive Periodontitis Families. Completed NCT03642353 Phase 4 Triclosan;Placebo
6 Treatment of Aggressive Periodontitis With Repeated Adjunctive Antimicrobial Photodynamic Therapy Completed NCT02049008 Phase 4
7 Host Modulatory Effects of β-glucan on Localized Aggressive Periodontitis Completed NCT02402296 Phase 4 β-1,3/1,6-D-glucan
8 Alternative Antibiotic Regime in the Treatment of GAgP Completed NCT02223702 Phase 4 Amoxicillin;Metronidazole;Moxifloxacin
9 Enamel Matrix Proteins in the Treatment of Intrabony Defects in Patients With Aggressive and Chronic Periodontitis Completed NCT03025204 Phase 4
10 Omega-3 Plus Low-dose Aspirin Daily Supplementation in Non-surgical Therapy to Treat Aggressive Periodontitis Unknown status NCT03093246 Phase 2, Phase 3 Aspirin
11 Omega-3 Fatty Acids Plus Low-dose Aspirin Daily Supplementation in Surgical Therapy to Treat Aggressive Periodontitis Unknown status NCT03093207 Phase 2, Phase 3 Aspirin
12 Two Different Antibiotic Agents to Treat Generalized Aggressive Periodontitis Completed NCT02969928 Phase 2, Phase 3 Clarithromycin;Amoxicillin;Metronidazole
13 Periodontal Debridement Associated With Systemic Antibiotics and Single/Repeated PDT to Treat Aggressive Periodontitis Completed NCT03132714 Phase 2, Phase 3 Amoxicillin 500mg;Metronidazole 400mg;Clarithromycin 500mg
14 Doxycycline in the Treatment of Aggressive Periodontitis Completed NCT03727620 Phase 1, Phase 2 amoxicillin plus metronidazole;Doxycycline
15 The Affect of Orthodontic Treatment on the Periodontal Status of Patients With Aggressive Periodontitis Unknown status NCT01510808
16 Subgingival Microbiome Following Mechanical Treatment and it's Effect on Peri-implant Sub-mucosa in Aggressive Periodontitis Patients Unknown status NCT03090282
17 Polymorphonuclear Cells' Sensitivity to Aggregatibacter Actinomycetemcomitans Bacteria in Patients With Aggressive Periodontitis Unknown status NCT02010307 Not Applicable
18 Chronic Presence of Epstein Barr Virus in Epithelial Cells From Gingiva is Associated With Periodontitis Unknown status NCT01246596 Not Applicable
19 B Cell Functions in Periodontitis Unknown status NCT02833285
20 Immunolocalization of 1,25,Dihydroxyvitamin D3 in Aggressive Periodontitis Patients Completed NCT02282800
21 Gene Expression Profiles in Generalized Aggressive Periodontitis: A Gene Network-based Microarray Analysis Completed NCT02327533
22 Metagenomic and Immune-inflammatory Analysis of Individuals With Generalized Aggressive Periodontitis and Their Descendants. Completed NCT03933514
23 Effects of Smoking on Non-surgical Periodontal Therapy in Generalized Aggressive Periodontitis Completed NCT03512938 Not Applicable
24 Effects Of Adjunctive Photodynamic Therapy To Non-Surgical Periodontal Treatment In Patients With Generalized Aggressive Periodontitis Completed NCT03412331 Not Applicable
25 Gingival Crevicular Fluid Levels Of Monocyte Chemoattractant Protein-1 Completed NCT02927704
26 Frequency Of MCP-1 And CCR2 Gene Polymorphisms And Its Effect On Gene Expression In Patients With AgP Completed NCT02817568
27 Effects of Er,Cr:YSGG, Diode Lasers on GCF Cytokines Levels Completed NCT03034824 Not Applicable
28 Clarithromycin as Adjuvant to Periodontal Debridement Completed NCT02829983 Not Applicable Clarithromycin;Placebo
29 Smoking Influence on Apoptosis in Periodontitis Completed NCT02111005
30 Nonsurgical Periodontal Treatment Associated or Not With Systemic Antibiotics and Photodynamic Therapy Completed NCT03142776 Not Applicable systemic clarithromycin
31 Tissue Alterations in Aggressive and Chronic Periodontitis Completed NCT03625414
32 Effect of Surgical Therapy on RANKL/OPG (Osteoprotegerin) System Completed NCT02190773
33 Estimation of Pentrexin-3 Levels in GCF and Saliva of Patients With Periodontal Disease Completed NCT03128502
34 Clinical, Immunological and Microbiological Evaluation of Experimental Gingivitis and Peri-implant Mucositis Completed NCT03713567 Not Applicable
35 Nitro-oxidative Stress in Periodontitis Completed NCT02127203
36 TNF-α/HIF-1α/VEGF Pathway in Periodontal Diseases Completed NCT03558906
37 Active Matrix Metalloproteinase-8 (aMMP-8) Chair-side Test in Different Periodontal Disease Completed NCT03527901
38 The Importance of Periostin in Periodontal Health and Disease Completed NCT01180920
39 Gingival Bleeding and Von Willebrand Disease Typ 2 and 3 Completed NCT03078595
40 Perforated Collagen Membrane With Nanohydroxyapatite for Intrabony Defects Completed NCT03399279 Not Applicable
41 Immediate Implant Placement in Aggressive Periodontitis Recruiting NCT03218228 Not Applicable
42 EMD for Treatment of Proximal Class-II Furcation Involvements Recruiting NCT03320135 Not Applicable
43 Mechanisms and Treatment Response of Aggressive Periodontitis in Children Active, not recruiting NCT01330719 Not Applicable
44 Comparison Between Surgical Access and Repeated Applications of APDT Active, not recruiting NCT03140059 Not Applicable
45 Interaction Between Immune Cells and Bacteria Associated With Periodontitis Active, not recruiting NCT03225950
46 Long-term Results After Systematic Periodontal Therapy Enrolling by invitation NCT03048045
47 Clinical and Radiographic Evaluation of Guided Tissue Regeneration With Radiation-sterilized Allogenic Bone Grafts or Xenogenic Grafts for the Treatment of Intrabony Defects in Aggressive Periodontitis Not yet recruiting NCT03340012 Not Applicable
48 Analysis of Osteoimmune Interactions Linking Inflammation and Bone Destruction in Aggressive Periodontitis Terminated NCT01993368 Not Applicable

Search NIH Clinical Center for Aggressive Periodontitis

Cochrane evidence based reviews: aggressive periodontitis

Genetic Tests for Aggressive Periodontitis

Anatomical Context for Aggressive Periodontitis

MalaCards organs/tissues related to Aggressive Periodontitis:

42
Bone, Neutrophil, Monocytes, Lung, B Cells, Testes, Eye

Publications for Aggressive Periodontitis

Articles related to Aggressive Periodontitis:

(show top 50) (show all 746)
# Title Authors Year
1
Identification of genetic risk factors of aggressive periodontitis using genomewide association studies in association with those of chronic periodontitis. ( 30303256 )
2019
2
Assessment of microRNA-146a in generalized aggressive periodontitis and its association with disease severity. ( 30328616 )
2019
3
Comparison of miRNA expression profiles in individuals with chronic or aggressive periodontitis. ( 30350903 )
2019
4
Effect of periodontal treatment on Aggregatibacter actinomycetemcomitans colonization and serum IgG levels against A. actinomycetemcomitans serotypes and Omp29 of aggressive periodontitis patients. ( 30506613 )
2019
5
6-months Clinical Outcomes of Non-Surgical Periodontal Treatment with Antibiotics on Apoptosis Markers in Aggressive Periodontitis. ( 30614174 )
2019
6
One-year follow-up of the immune profile in serum and selected sites of generalized and localized aggressive periodontitis. ( 30684915 )
2019
7
Protein carbonyl levels in serum, saliva and gingival crevicular fluid in patients with chronic and aggressive periodontitis. ( 30705565 )
2019
8
Comparison of the oral microbiome of patients with generalized aggressive periodontitis and periodontitis-free subjects. ( 30710838 )
2019
9
A Double-Crown Concept for Restorations in Patients with Generalized Aggressive Periodontitis: Two Case Reports with 22- and 25-Year Follow-ups. ( 30794256 )
2019
10
Regeneration of the Periodontal Apparatus in Aggressive Periodontitis Patients. ( 30857253 )
2019
11
Response to "Identification of genetic risk factors of aggressive periodontitis using genome-wide association studies in association with those of chronic periodontitis". ( 30900245 )
2019
12
Management of periodontic-endodontic lesion in aggressive periodontitis-9 months follow-up: Report of a case. ( 30900677 )
2019
13
Subgingival microbiome in Chinese patients with generalized aggressive periodontitis compared to healthy controls. ( 30909081 )
2019
14
Comparison of Subgingival and Buccal Mucosa Microbiome in Chronic and Aggressive Periodontitis: A Pilot Study. ( 30915280 )
2019
15
Periodontal Regeneration with Enamel Matrix Derivative in the Management of Generalized Aggressive Periodontitis: A Case Report with 11-Year Follow-up and Literature Review. ( 30923688 )
2019
16
Clinical and radiographic peri-implant outcomes of short dental implants placed in posterior jaws of patients with treated generalized aggressive periodontitis: A 3-year follow-up study. ( 30938040 )
2019
17
Periodontal tissue destruction in aggressive periodontitis: Determination of gene or environmental factors. ( 30983842 )
2019
18
Association of CYP1A1 rs1048943 variant with aggressive periodontitis and its interaction with hyperlipidemia on the periodontal status. ( 31032950 )
2019
19
Aggregatibacter actinomycetemcomitans (Aa) Under the Radar: Myths and Misunderstandings of Aa and Its Role in Aggressive Periodontitis. ( 31040843 )
2019
20
Exome sequencing identifies a novel missense variant in CTSC causing nonsyndromic aggressive periodontitis. ( 31068678 )
2019
21
A novel U-shaped relationship between BMI and risk of generalized aggressive periodontitis in Chinese: A cross-sectional study. ( 29944736 )
2019
22
Validation of reported GLT6D1 (rs1537415), IL10 (rs6667202), and ANRIL (rs1333048) single nucleotide polymorphisms for aggressive periodontitis in a Brazilian population. ( 30030838 )
2019
23
Efficacy of adjunctive photodynamic therapy in the treatment of generalized aggressive periodontitis: A randomized controlled clinical trial. ( 30095173 )
2019
24
Vitamin D deficiency in patients with aggressive periodontitis. ( 30169905 )
2019
25
A comparative study of synbiotic as an add-on therapy to standard treatment in patients with aggressive periodontitis. ( 30210194 )
2018
26
Oral health-related quality of life and standard of treatment in aggressive periodontitis patients more than 5 years after therapy. ( 30216484 )
2018
27
Evaluation of the local effect of nonsurgical periodontal treatment with and without systemic antibiotic and photodynamic therapy in generalized aggressive periodontitis. A randomized clinical trial. ( 30227258 )
2018
28
Early postoperative healing following guided tissue regeneration in aggressive periodontitis patients. ( 30328307 )
2018
29
The role of three interleukin 10 gene polymorphisms (- 1082 A > G, - 819 C > T, - 592 A > C) in the risk of chronic and aggressive periodontitis: a meta-analysis and trial sequential analysis. ( 30348144 )
2018
30
Functional Polymorphisms of CTLA4 Associated with Aggressive Periodontitis in the Chinese Han Population. ( 30355938 )
2018
31
Treatment of intrabony defects with modified perforated membranes in aggressive periodontitis: subtraction radiography outcomes, prognostic variables, and patient morbidity. ( 30374832 )
2018
32
Multidisciplinary Clinical Management of a Localized Aggressive Periodontitis diagnosed in a Child with Glanzmann's Thrombasthenia. ( 30397380 )
2018
33
Expression of growth mediators in the gingival crevicular fluid of patients with aggressive periodontitis undergoing periodontal surgery. ( 30498980 )
2018
34
Five-year results of nonsurgical treatment to manage severe generalized aggressive periodontitis. ( 30574612 )
2018
35
Patients with history of aggressive periodontitis seem to have good oral health-related quality of life 5 years after treatment. ( 30577948 )
2018
36
Comparison of gingival crevicular fluid periostin levels in healthy, chronic periodontitis, and aggressive periodontitis. ( 30631225 )
2018
37
Biomarker levels in gingival crevicular fluid of generalized aggressive periodontitis patients after non-surgical periodontal treatment. ( 28918557 )
2018
38
CCR5Δ32 (rs333) polymorphism is associated with decreased risk of chronic and aggressive periodontitis: A case-control analysis based in disease resistance and susceptibility phenotypes. ( 28969941 )
2018
39
Dental anxiety and oral health-related quality of life in aggressive periodontitis patients. ( 29022175 )
2018
40
Clinical Characteristics of Localized Aggressive Periodontitis in Primary Dentition. ( 29087795 )
2018
41
Radiographic Description of the Distribution of Aggressive Periodontitis in Primary Teeth. ( 29087797 )
2018
42
Moderate- to long-term therapeutic outcomes of treated aggressive periodontitis patients without regular supportive care. ( 29105779 )
2018
43
Definition of aggressive periodontitis in periodontal research. A systematic review. ( 29226356 )
2018
44
Shift in the subgingival microbiome following scaling and root planing in generalized aggressive periodontitis. ( 29266363 )
2018
45
Localised aggressive periodontitis in a 3-year-old-boy. ( 29332208 )
2018
46
Diagnosis of aggressive periodontitis: A dilemma? ( 29363676 )
2018
47
Treatment of intrabony defects with modified perforated membranes in aggressive periodontitis: a 12-month randomized controlled trial. ( 29411112 )
2018
48
Impact of aggressive periodontitis and chronic periodontitis on oral health-related quality of life. ( 29451591 )
2018
49
Association analysis of FAS-670A/G and FASL-844C/T polymorphisms with risk of generalized aggressive periodontitis disease. ( 29541461 )
2018
50
Human herpesviruses may be associated with the development of aggressive periodontitis. ( 29548690 )
2018

Variations for Aggressive Periodontitis

Expression for Aggressive Periodontitis

Search GEO for disease gene expression data for Aggressive Periodontitis.

Pathways for Aggressive Periodontitis

Pathways related to Aggressive Periodontitis according to GeneCards Suite gene sharing:

(show top 50) (show all 71)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14.04 CTSC CXCL8 FCGR2A FCGR3B FPR1 IL10
2
Show member pathways
13.74 CXCL8 IL10 IL1A IL1B IL1RN IL4
3
Show member pathways
13.48 CXCL8 IL10 IL1A IL1B IL4 IL6
4
Show member pathways
13.44 CXCL8 FPR1 IL10 IL1A IL1B IL1RN
5
Show member pathways
13.37 CXCL8 IL10 IL1A IL1B IL4 IL6
6
Show member pathways
13.13 CXCL8 IL10 IL1B IL6 TLR4 TNF
7
Show member pathways
12.97 CXCL8 IL10 IL1A IL1B IL4 IL6
8
Show member pathways
12.79 CXCL8 IL1B IL6 TLR4 TNF
9
Show member pathways
12.74 IL1A IL1B IL6 TLR4 TNF
10
Show member pathways
12.71 IL10 IL1A IL1B IL4 IL6 TLR4
11
Show member pathways
12.68 IL10 IL1A IL1B IL4 IL6 TNF
12 12.67 IL10 IL1B IL1RN IL4 TNF TNFSF11
13
Show member pathways
12.66 IL1A IL1B TLR4 TNF TNFSF11
14
Show member pathways
12.44 CXCL8 IL1A IL1B IL6 TLR4 TNF
15
Show member pathways
12.43 CXCL8 IL1B IL4 IL6 TNF
16
Show member pathways
12.38 CXCL8 IL10 IL1A IL1B IL4 IL6
17
Show member pathways
12.37 IL1B IL4 IL6 TNF
18
Show member pathways
12.37 CXCL8 IL1A IL6 TLR4 TNF
19
Show member pathways
12.35 FCGR2A FCGR3B IL10 IL1A IL1B IL4
20
Show member pathways
12.34 CXCL8 IL1A IL1B IL1RN IL6 TNF
21
Show member pathways
12.3 CXCL8 IL1B IL4 IL6 TLR4 TNF
22 12.3 CXCL8 IL10 IL1A IL1B IL1RN IL6
23
Show member pathways
12.26 IL10 IL1B IL6 TNF
24
Show member pathways
12.26 IL1A IL1B TLR4 TNF
25
Show member pathways
12.24 CXCL8 IL1A IL1B MMP8 TLR4
26
Show member pathways
12.18 CXCL8 IL10 IL1A IL1B IL4 IL6
27
Show member pathways
12.18 IL10 IL1B IL6 TLR4 TNF
28
Show member pathways
12.18 FCGR2A FCGR3B IL1B IL4 IL6 TLR4
29 12.16 FCGR2A FCGR3B IL1A IL1B TNF TNFSF11
30 12.13 FCGR2A IL10 IL4 IL6 TNF
31 12.12 CXCL8 IL10 IL1A IL1B IL4 IL6
32 12.06 FCGR2A FCGR3B IL10 IL1A IL1B IL6
33 12.05 CXCL8 IL1A IL1B IL6 TNF
34 12.04 CXCL8 IL1B TLR4 TNF TNFSF11
35 12.03 CXCL8 IL1A IL1B IL6
36 12.03 IL1A IL1B IL4 IL6 TNF
37 12.02 CXCL8 IL10 IL1B IL6 TLR4 TNF
38 11.97 CXCL8 IL1A IL1B IL6 TLR4
39 11.96 IL1B IL6 TNF
40 11.94 CXCL8 IL1A IL1B IL6 TLR4 TNF
41 11.94 CXCL8 FCGR2A IL1A IL1B IL4 IL6
42 11.9 IL10 IL1B IL4 TNF
43
Show member pathways
11.88 CXCL8 IL6 TLR4
44 11.86 IL10 IL1B IL6 TNF
45 11.84 FCGR2A FCGR3B TLR4
46 11.83 CXCL8 IL4 IL6
47 11.81 FCGR2A FCGR3B FPR1 IL10
48 11.8 CXCL8 IL1B IL4 IL6 TNF
49
Show member pathways
11.79 CXCL8 IL4 TNF
50
Show member pathways
11.79 CXCL8 IL1A IL1B IL6 TNF

GO Terms for Aggressive Periodontitis

Cellular components related to Aggressive Periodontitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.7 CTSC CXCL8 IL10 IL1A IL1B IL1RN
2 extracellular region GO:0005576 9.4 CTSC CXCL8 FCGR3B IL10 IL1A IL1B
3 secretory granule membrane GO:0030667 9.33 FCGR2A FCGR3B FPR1

Biological processes related to Aggressive Periodontitis according to GeneCards Suite gene sharing:

(show top 50) (show all 60)
# Name GO ID Score Top Affiliating Genes
1 cellular response to lipopolysaccharide GO:0071222 9.98 CXCL8 IL10 IL1B IL1RN IL6 TLR4
2 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 9.97 IL1B IL1RN TLR4 TNF TNFSF11
3 positive regulation of gene expression GO:0010628 9.97 IL1A IL1B IL4 IL6 MMP8 TLR4
4 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.96 IL1B IL6 TLR4 TNF TNFSF11
5 activation of MAPK activity GO:0000187 9.93 FPR1 IL1B TLR4 TNF
6 positive regulation of JNK cascade GO:0046330 9.93 IL1B IL1RN MMP8 TLR4 TNF TNFSF11
7 positive regulation of DNA-binding transcription factor activity GO:0051091 9.91 IL10 IL1B IL6 TNF TNFSF11
8 response to organic substance GO:0010033 9.89 CTSC IL10 TNF
9 neutrophil chemotaxis GO:0030593 9.89 CXCL8 IL1B IL1RN
10 positive regulation of T cell proliferation GO:0042102 9.87 IL1B IL4 IL6
11 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.87 IL1B MMP8 TLR4 TNF
12 interleukin-1-mediated signaling pathway GO:0070498 9.86 IL1A IL1B IL1RN
13 positive regulation of interferon-gamma production GO:0032729 9.85 IL1B TLR4 TNF
14 positive regulation of nitric oxide biosynthetic process GO:0045429 9.85 IL1B MMP8 TLR4 TNF
15 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001240 9.82 IL1A IL1B TNF
16 lipopolysaccharide-mediated signaling pathway GO:0031663 9.81 IL1B TLR4 TNF
17 inflammatory response GO:0006954 9.81 CXCL8 FPR1 IL10 IL1A IL1B IL1RN
18 negative regulation of interleukin-6 production GO:0032715 9.8 IL10 TLR4 TNF
19 positive regulation of cytokine secretion GO:0050715 9.8 IL10 IL1A TNF
20 positive regulation of interleukin-8 production GO:0032757 9.79 IL1B TLR4 TNF
21 negative regulation of neurogenesis GO:0050768 9.79 IL1B IL6 TNF
22 positive regulation of chemokine production GO:0032722 9.78 IL6 TLR4 TNF
23 response to glucocorticoid GO:0051384 9.78 IL10 IL1RN IL6 TNF
24 positive regulation of glial cell proliferation GO:0060252 9.77 IL1B IL6 TNF
25 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.76 IL10 IL1B TNF
26 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.73 IL1B TNF
27 negative regulation of growth of symbiont in host GO:0044130 9.73 IL10 TNF
28 positive regulation of interleukin-6 production GO:0032755 9.73 IL1B IL1RN IL6 MMP8 TLR4 TNF
29 regulation of osteoclast differentiation GO:0045670 9.72 TNF TNFSF11
30 positive regulation of reactive oxygen species biosynthetic process GO:1903428 9.72 MMP8 TLR4
31 positive regulation of interleukin-2 biosynthetic process GO:0045086 9.72 IL1A IL1B
32 response to molecule of bacterial origin GO:0002237 9.71 CXCL8 IL10
33 negative regulation of heterotypic cell-cell adhesion GO:0034115 9.71 IL10 IL1RN
34 positive regulation of interleukin-8 biosynthetic process GO:0045416 9.71 TLR4 TNF
35 negative regulation of lipid storage GO:0010888 9.71 IL6 TNF
36 positive regulation of MHC class II biosynthetic process GO:0045348 9.71 IL10 IL4 TLR4
37 positive regulation of neuroinflammatory response GO:0150078 9.71 IL1B IL6 MMP8 TNF
38 endothelial cell apoptotic process GO:0072577 9.7 IL10 TNF
39 positive regulation of chemokine biosynthetic process GO:0045080 9.7 IL1B TNF
40 ectopic germ cell programmed cell death GO:0035234 9.7 IL1A IL1B
41 regulation of establishment of endothelial barrier GO:1903140 9.69 IL1B TNF
42 negative regulation of cytokine secretion involved in immune response GO:0002740 9.69 IL10 TNF
43 negative regulation of interleukin-1-mediated signaling pathway GO:2000660 9.68 IL1RN IL6
44 positive regulation of fever generation GO:0031622 9.68 IL1B TNF
45 regulation of isotype switching GO:0045191 9.67 IL10 IL4
46 sequestering of triglyceride GO:0030730 9.67 IL1B TNF
47 type 2 immune response GO:0042092 9.67 IL10 IL4
48 fever generation GO:0001660 9.66 IL1A IL1B
49 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.65 IL1B TNF
50 receptor biosynthetic process GO:0032800 9.65 IL10 TNF

Molecular functions related to Aggressive Periodontitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.28 CXCL8 IL10 IL1A IL1B IL1RN IL4
2 IgG binding GO:0019864 9.16 FCGR2A FCGR3B
3 interleukin-1 receptor binding GO:0005149 9.13 IL1A IL1B IL1RN

Sources for Aggressive Periodontitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
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50 NCI
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58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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